1 The hominoid-specific gene TBC1D3 promotes generation of basal neural 2 progenitors and induces cortical folding in mice 3 4 Xiang-Chun Ju1,3,9, Qiong-Qiong Hou1,3,9, Ai-Li Sheng1, Kong-Yan Wu1, Yang Zhou8, 5 Ying Jin8, Tieqiao Wen7, Zhengang Yang6, Xiaoqun Wang2,5, Zhen-Ge Luo1,2,3,4 6 7 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for 8 Biological Sciences, Chinese Academy of Sciences, Shanghai, China. 9 2CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 10 China. 11 3Chinese Academy of Sciences University, Beijing, China. 12 4ShanghaiTech University, Shanghai, China 13 5Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 14 6Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan 15 University, Shanghai, China. 16 7School of Life Sciences, Shanghai University, Shanghai, China. 17 8The Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese 18 Academy of Sciences, Shanghai, China. 19 9Co-first author 20 Correspondence should be addressed to Z.G.L (
[email protected]) 21 22 Author contributions 23 X.-C.J and Q.-Q. H performed most experiments, analyzed data and wrote the paper. 24 A.-L.S helped with in situ hybridization. K.-Y.W assisted with imaging analysis. T.W 25 helped with the construction of nestin promoter construct. Y. Z and Y. J helped with 26 ReNeuron cell culture and analysis. Z.Y provided human fetal samples and assisted with 1 27 immunohistochemistry analysis. X.W provided help with live-imaging analysis. Z.-G.L 28 supervised the whole study, designed the research, analyzed data and wrote the paper.