Sustainability Report 2014-2015

Roche Latin America

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Roche Latin America Produtos Roche Químicos e Farmacêuticos S.A. Av. Engenheiro Billings, 1.729 – Jaguaré CEP 05321-900 – São Paulo/SP, Brazil

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Argentina Ecuador Productos Roche S. A. Q. e I. Roche Ecuador S.A. Rawson 3150, (B1610BAL), Ricardo Rojas, Tigre Av. 10 de Agosto N36-239 y Naciones Unidas, Casilla: 1711-06185 Província de Buenos Aires, Argentina Quito, Ecuador

Brazil Mexico Produtos Roche Químicos e Farmacêuticos S.A. Productos Roche S. A. de C.V. Av. Engenheiro Billings, 1.729 – Jaguaré Cerrada de Bezares No. 9 CEP 05321-900 – São Paulo/SP, Brazil Col. Lomas de Bezares 11910, Mexico, D.F. Central America and the Caribbean Productos Roche S.A. Peru Zona Franca Ultrapark, Edificio 4 Roche Perú La Aurora, Heredia, Costa Rica San Isidro, Dionísio Derteano 144 of. 1301 Lima, Peru Chile Roche Chile Ltda. Uruguay Av. Cerro el Plomo 5630, Piso 12. Las Condes. Roche International Ltd Santiago, Chile WTC - Torre 4, Piso 5, Luis Bonavita, 1266 Montevideo, Uruguay Colombia Productos Roche S.A. Venezuela Carrera 44 No. 20-21 Produtos Roche S.A. Bogotá, Colombia Edificio Roche, Av. Diego Cisneros, Los Ruices Caracas, Venezuela

4 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 5 Welcome to our Sustainibility Report 2014-2015

Contents

1. This Report ...... 9 8. Colombia ...... 97 Roche Colombia at a Glance ...... 98 2. Global Overview ...... 11 Healthcare in Colombia ...... 99 Roche at a Glance ...... 11 Roche in Colombia ...... 99 Roche Group Profile...... 15 Sustainability Initiatives ...... 101 Sustainability Strategy ...... 15 9. Ecuador ...... 109 3. Latin America ...... 25 Roche Ecuador at a Glance ...... 110 Roche Latin America at a Glance ...... 26 Healthcare in Ecuador ...... 111 Healthcare in Latin America ...... 29 Roche in Ecuador ...... 111 Roche in Latin America ...... 31 Sustainability Initiatives ...... 113 Sustainability Initiatives ...... 33 10. Mexico ...... 119 4. Argentina ...... 45 Roche Mexico at a Glance ...... 120 Roche Argentina at a Glance ...... 46 Healthcare in Mexico ...... 121 Healthcare in Argentina ...... 47 Roche in Mexico ...... 121 Roche in Argentina ...... 47 Sustainability Initiatives ...... 123 Sustainability Initiatives ...... 49 11. Peru ...... 131 5. Brazil ...... 59 Roche Peru at a Glance ...... 132 Roche Brazil at a Glance ...... 60 Healthcare in Peru ...... 133 Healthcare in Brazil ...... 61 Roche in Peru ...... 134 Roche in Brazil ...... 61 Sustainability Initiatives ...... 135 Sustainability Initiatives ...... 63 12. Uruguay ...... 143 6. Central America and the Caribbean ...... 73 Roche Uruguay at a Glance ...... 144 Roche Central America and the Caribbean at a Glance . . . . . 74 Healthcare in Uruguay ...... 145 Healthcare in Central America Roche in Uruguay ...... 145 and the Caribbean ...... 75 Sustainability Initiatives ...... 147 Roche in Central America and the Caribbean ...... 75 Sustainability Initiatives ...... 77 13. Venezuela ...... 157 Roche Venezuela at a Glance ...... 158 7. Chile ...... 85 Healthcare in Venezuela ...... 159 Roche Chile at a Glance ...... 86 Roche in Venezuela ...... 159 Healthcare in Chile ...... 87 Sustainability Initiatives ...... 161 Roche in Chile ...... 87 Sustainability Initiatives ...... 89

6 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 7 This Report

At Roche, we are dedicated to doing good business that contrib- Roche’s most recent sustainability report, 2015 Global Report,(1) utes to a better world. Everything we do as a company is guided follows the GRI G4 standards, and its content is guided by an by our commitment to scientific rigor, unassailable ethics, and updated global materiality assessment. The regional office of access to medical innovations for all. We value transparency Roche in Latin America(2) follows the Group’s approach, and and ethical management, and public reporting on our activities our second regional Sustainability Report is informed by the and results is an important tool for promoting both. The Group GRI G4 methodology. has been publishing a sustainability report for more than 10 years and has adopted the guidelines of the Global Reporting This report covers Roche’s economic, social, and environmental Initiative (GRI). impacts in Latin America for the two-year period from January 1, 2014 to December 31, 2015. The content covers the Pharmaceu- ticals Division in the 10 affiliates comprising the regional group: Argentina, Brazil, Central America and the Caribbean, Chile, Colombia, Ecuador, Mexico, Peru, Uruguay, and Venezuela. The data highlighted in this report are based on key performance in- dicators in all of the listed affiliates.

We value transparency Roche believes sustainability is an on-going journey of continuous improvement. This report reflects a moment in time on that and ethical management, journey, and Roche is committed to strengthening and expanding its sustainability management processes and tools in the future. and public reporting on our activities and results (1) Roche Annual Report 2015: www.roche.com/gb15e.pdf is an important tool for (2) In this report, “Roche in Latin America” only refers to its Pharmaceuticals Division. promoting both.

8 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 9 Global Overview

Roche at a Glance

A global leader in innovation A sustainable company A great workplace Roche is the world’s largest biotech- Roche is committed to business Roche is driven by a shared set of nology company and a leader in re- practices that are sustainable, ethi- values including integrity, the cour- search-focused healthcare. cal and responsible to create long- age to reach beyond boundaries term value . and a passion for what we do.

+100 #1 #1 #1 Countries in biotech in oncology and in hospital markets in vitro diagnostics

48.1 9.3 91,747 billion CHF(3) in sales billion CHF in Employees R&D investment (full-time equivalents)

29 70 40% Roche medicines on WHO new medical entities in Women Essential Medicines List clinical development in management roles

25,000,000 +300,000 Patients treated Patients in clinical trials with one of Roche’s top 25 selling products

2015 data Figures include Pharmaceutical and Diagnostics divisions.

For further information: www.roche.com

(3) Swiss francs

10 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 11 Who we are

Innovation: it’s in our DNA. At Roche we have always worked across As the world’s largest biotech company, we develop breakthrough disciplines and geographies to drive scientific discovery and redefine medicines, improving the standard of care across oncology, im- what is possible to improve patients’ lives. munology, infectious diseases, ophthalmology and neuroscience. We are also the world leader in the in vitro diagnostics business. We work towards understanding how diseases differ down to the This track record allows us to build lasting and meaningful part- molecular level in order to develop new tests and medicines that nerships across the world with research academia and public prevent, diagnose and treat diseases that matter and bring them to healthcare institutions. the patients who need them. With our combined strengths in diagnostics and pharmaceuticals, our personalised healthcare strategy We remain dedicated to the highest standards of quality, safety and aims to fit the right treatment to the right patient. integrity. Our legacy is based on respect for the individual, as well as the communities and the world we live in.

Our values Integrity starts with me. Discovery starts with passion. We are consistently open, honest and genuine. We use our drive and commitment to energise, engage and inspire others. Just as we expect it from ourselves and our colleagues, society expects that we live by high standards of integrity. Integrity starts Above all, our passion is to improve patients’ lives, and it is this with being honest with oneself and understanding one’s own passion that fuels our determination and enables us to persevere, strengths and weaknesses. It is also about interacting with others often over many years. Passion can express itself in highly visible in an open, genuine way. That is a must for building a strong re- ways – such as an enthusiastic speech or a persuasive presentation. lationship of trust with anyone, whether inside or outside Roche. It can also be low key – such as persistently repeating an experi- We must act ethically and honestly at all times. ment over and over again to determine whether an unexpected result was just an error or possibly an important new discovery.

Success starts with courage. We are entrepreneurial, taking risks, experimenting and reaching beyond boundaries.

Our business and strategy takes us often into uncharted territory. This also means that we must have the courage to take appropri- Above all, our passion ate risks in order to succeed. This means we need to think like entrepreneurs and be prepared to try new ways of doing things is to improve patients’ even if we are convinced that the traditional ways are right. We may not always feel comfortable about taking a minority view or lives, and it is this expressing criticism. Yet if we don’t speak up, we run the risk of not tackling necessary changes, whether out of complacency or passion that fuels our an ill-conceived desire for harmony. Being courageous will ensure we can remain successful and stay ahead in the long run. determination and enables us to persevere, often over many years.

12 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 13 Roche Group Profile Roche is a global healthcare pioneer advancing science for human- To date the Roche Group has helped to improve peoples’ health and ity. We are committed to bringing these advances to everyone who quality of life in more than 150 countries all over the world. As a needs them, no matter where they live. And this is our promise: to world leader in research on healthcare products, the company op- care about this generation, as well as the ones to come. erates exclusively in the fields of pharmaceuticals and diagnostics. The founding families continue to hold the majority stake in the Founding Roche in 1896, more than 100 years ago in Switzerland, company. This stability allows for a tradition of sustainable think- our company’s founder, Fritz Hoffmann, turned a pioneering idea ing, allowing us to learn from setbacks and pass down lasting value into reality: that a partnership between business and science can for patients and society. improve peoples’ lives. Expanding globally, our founders tackled obstacles, worked across disciplines and cultures and embraced risks. This is still how we transform lives, provide cures, comfort and hope, to make a difference in the health of millions.

Sustainability Strategy Innovation for Patients – Access to Healthcare

The Sustainable Development Goals adopted by the Member In addition, the Roche Group invests heavily in cutting edge States of the United Nations in September 2015 include the pro- research and development (R&D) as part of its commitment to motion of ‘good health and well-being.’ As a global healthcare innovation for patients. Core R&D investments in 2015 totalled company, Roche has the opportunity to actively commit and 9.3 billion CHF, or 19.4% of sales with pharmaceuticals repre- contribute to achieving this important societal goal. In this vein, senting a large portion of this corporate commitment. Roche has developed five primary pillars that focus on patients and improved access to healthcare: Delivering Innovation, In- External innovation is also crucial to Roche’s strategy of bringing creasing Disease Awareness, Strengthening Healthcare Infra- critical treatments to patients in areas of unmet medical need. We structure, Improving Affordability and Supporting Local Patient currently manage over 200 partnerships worldwide. Our teams Organisations. of experts work closely with internal R&D groups to gauge needs and gaps. At the same time, they track emerging companies on academic advances and on other collaborative opportunities, Delivering Innovation screening thousands of potential partners a year before selecting those that will truly help Roche advance drug discovery and de- Roche’s most powerful contribution in this area lies in develop- velopment in an impactful way. ing tests and medicines to meet some of the most urgent medical needs worldwide. It is here that we explore ideas, face setbacks and relentlessly pursue new approaches to make true advances Increasing Disease Awareness against disease. Our employees remain dedicated to transforming science into breakthrough medicines and diagnostics to improve Improving access to medicines and diagnostics is vital, but still the life of each patient in the best way possible. not enough to improve global healthcare. A holistic approach of health education and awareness is also critically important to a In pharmaceuticals, Roche is a global leader in oncology, tack- patient’s long-term outcome. As such, we support local commu- ling melanoma, breast, ovarian, cervical and lung cancer, diffi- nity partners to run screening, awareness and counselling pro- cult-to-treat indolent non-Hodgkin lymphoma and many others. grammes, and help empower people worldwide with the knowl- Roche has made important contributions to significantly lower- edge to safeguard and manage their own health. ing cancer mortality rates globally over the past 20 years. In 18 years, Roche has developed 11 cancer treatments with proven Through our collaborative efforts with patient groups, hospitals survival benefit to patients. and health organisations around the world, we help increase awareness of diseases such as cancer, rheumatoid arthritis, hep- Beyond oncology, Roche is forging innovative treatments in im- atitis, osteoporosis and diabetes. We also conduct screening pro- munology, particularly multiple sclerosis (MS). MS affects ap- grammes for the early detection of these diseases and publish proximately 2.3 million people worldwide; thus, effective treat- information on newsletters, magazines and other publications ment and diagnosis can have impact at scale, improving quality aimed at helping people make healthy choices and changing be- of life for those around the world. haviours to prevent disease.

14 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 15 Innovation for Patients – Access to Healthcare (cont.)

Additional information is also developed specifically for patients, We believe that all players are required — public authorities, In a complex global market, we understand that the value of our Supporting Patient Organisations families and caregivers who operate counselling services to help non-governmental stakeholders, patient organisations, local products, the ability of healthcare systems and individuals to pay them understand diseases and the proper use of our products. communities, the healthcare industry and others — to work for them varies greatly across different regions. To address this Roche takes patient engagement very seriously and endeavours They can also find details on the latest information about tests closely together to improve health and well-being. As a global issue, we are exploring new pricing models that are tailored to to support patient organisations’ objectives wherever possible. and treatment options on a variety of websites that Roche has healthcare company, Roche plays a key role and shares a respon- the dynamics of each healthcare system, rather than a uniform We believe that together, we can spark meaningful change for helped develop. sibility to tackle the challenges of improving health outcomes. pricing structure. the future of human health. Today our interactions with patient That’s why we are committed to working with partners at the local groups are multifaceted and range from funding organisations level to overcome barriers and improve access to tests and medi- Through this unique approach, we hope to find solutions that and building capacity to organising meetings and supporting ad- Strengthening Healthcare Infrastructure cines for all patients. allow us to continue to invest in the research and development vocacy. The International Experience Exchange for Patient Or- of products that can transform patients’ lives, while balancing ganisation (IEEPO), Roche’s largest global patient organisation Roche believes a multi-stakeholder approach to access and infra- the needs of our stakeholders and our commitment to improv- meeting, was held in Munich in 2015 and focused on the vital structure is key to getting innovation to the patients who need Improving Affordability ing access. role of patient organisations. A record total of 189 delegates from treatment most. Many Roche-developed products can make 41 countries attended IEEPO 2015, and agreed that the potential healthcare delivery more efficient by improving the mode of -ad When a new product is brought to market, we work closely with role patients can play in research, clinical trial design and recruit- ministration, or reducing the time patients spend in the hospital. governments, insurers and other healthcare providers to deter- ment, HTA and other aspects of drug development and access, In addition, advances in science have led to personalised health- mine its value. This enables us to demonstrate the value of the could and should increase significantly. care that focuses on providing the right treatment for the right product to patients, their families, healthcare professionals, pay- R&D investments in patient. Unlike previous one-size-fits-all methods, personalised ers and society in general, in order to gain appropriate reimburse- We believe in delivering medical solutions urgently, even as we healthcare recognises that each patient is unique, and by using ment. We consider numerous factors when determining value, 2015 totalled 9.3 billion develop innovations for the future. That’s why we are committed specific diagnostic tests, doctors can now predict how well a pa- including: the effectiveness of our medicine or diagnostic; other to working with partners at the local, regional and global level to tient responds to treatment for certain diseases or conditions. medicines or diagnostics used to treat or test the same disease; fu- CHF, or 19.4% of sales. overcome barriers and improve access to tests and medicines for These tests also enable physicians to determine the best dosage ture investment needed to discover new medicines and diagnos- all patients. and duration of treatment. tics; how to ensure that our products get to the people who need them; and the affordability of our product to healthcare systems and individuals.

16 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 17 Great Workplace for Employees Responsible and Compliant Partners

As a science and innovation-driven company, Roche’s most im- Roche is committed to increasing the representation of key lead- Compliance is our license to operate and serves as a foundation to All Roche employees are expected to follow the integrity guide- portant global asset is our people. We are committed to providers with established and developing regional experience and build and maintain trust with our stakeholders. Stakeholder en- lines outlined in the Roche Group Code of Conduct. In addition ing the best possible working environment so they can thrive. providing opportunities for our employees to work in different gagement is a key pillar of Roche’s comprehensive sustainability to employees, Roche’s suppliers and service providers are ex- Globally, we are focused on expanding diversity and inclusion, environments. We are also committed to increasing the represen- management process. This allows us to identify and prioritise ma- pected to adhere to similar standards. Our Roche Supplier Code providing leadership opportunities for employees and providing tation of women in key leadership positions. In 2015 we made terial issues, like at our yearly Sustainability Forum, where more of Conduct is included in contracts and we offer an e-Learning a healthy, productive work environment that cares for employees. progress on this goal, with women now accounting for at least than 80 internal stakeholders and external experts discuss inno- programme to help our suppliers and service providers increase 23% of leaders in key leadership positions and for 40% of man- vations in the supply chain, how to improve access to healthcare their knowledge and understanding of Roche’s expectations and Our five-year goals for people management globally include: agement overall. and elevate sustainability reporting at the partner level, and how of industry standards. Roche also maintains a stringent process to • A 30% increase in the representation of women in key leader- to enhance employee engagement. qualify and audit current and new suppliers and service provid- ship roles Roche also offers a variety of work-life balance and wellness pro- ers. In 2015 we conducted more than 1,000 audits of global and • A 30% increase in the representation of people with estab- grammes to employees including opportunities to work remotely, local suppliers and service providers. lished and developing region experience allowances for family leave, health and wellness education, bene- • A top quartile ranking in overall employee engagement score, fits and flexible work schedules. Ensuring patient safety and the effectiveness of our medicinal measured by the Global Employee Opinion Survey (GEOS) products is our top priority. We collaborate with regulatory agen- Roche has consistently been recognised as one of the best com- In 2015 we conducted cies, monitor reports of adverse events experienced by patients Diversity and inclusion are vital as the global marketplace is in- panies to work for. The company has been consistently awarded and communicate on our product safety activities. creasingly connected. Our business is different across our divi- placement on several ‘Great Place to Work’ lists, including the more than 1,000 audits sions and the world and employees who understand those dif- Fortune 100 best companies list, Working Mother magazine’s ferences are critical to our success. An inclusive culture fosters 100 best companies list, and DiversityInc’s 25 most noteworthy of global and local innovation by encouraging different perspectives, ideas and companies. thinking styles. In 2015 we defined what diversity and inclusion suppliers and service means to us and formalised the Diversity & Inclusion Practi- tioners’ Network to ensure that leaders are aligned in the way we providers. bring this commitment to life in our day-to-day business.

18 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 19 Supporting Communities Protecting the Environment

Roche is committed to global philanthropic activities including Safety, security, health and environmental protection are import- We measure our total environmental impact using the eco-bal- community involvement, humanitarian projects, science, edu- ant and enduring issues in a changing world. At Roche we refer to ance metric developed by the Swiss Federal Office for the Envi- cation, art and culture. We seek to support local communities activities that address these areas as SHE. We believe that protect- ronment. This metric provides us with a global view of how we through long-lasting partnerships. Following natural disasters ing people and the environment isn’t just a legal or social obliga- are impacting the Earth’s ecosystems. Our strategic five-year goal such as the 2015 Nepal earthquake and flooding in Malawi and tion, it’s integral to our operations. For that reason, we approach is to reduce our eco-balance by 10% by 2019. Pakistan, Roche works with local partners to provide immedi- SHE with the same sense of responsibility – and just as method- ate support with essential donations of medicines and long-term ically – as we do issues concerning product quality, productivity support to help communities rebuild. Roche has provided finan- and cost efficiency. Roche has provided cial support and donated millions of treatments for relief efforts, including medical products to treat and prevent infectious dis- Prevention is a key element in all our activities. Our corporate financial support and eases in the wake of natural disasters. policies and guidelines outline our commitments for ensuring the safety of people and protecting the environment. We maintain donated millions of Roche also has a long-standing philanthropic commitment in these standards by adhering to laws and regulations, by cooper- Protecting people and the Malawi, Southeast Africa. Since 2003 Roche has supported ed- ating with authorities and by communicating openly and frankly treatments for relief ucation programmes for HIV/AIDS-orphaned children in the about our activities. environment is integral to region. Each year employees donate money and time as part of efforts. Roche Children’s Walk reaching over 17,000 children in the re- Research and pharmaceutical and diagnostic manufacturing are our operations. gion as well as 90 local communities globally over the past 12 dependent on natural resources, which are becoming increasing- years of the programme. ly scarce. At Roche, our goal is to minimise our impact on the environment and to increase the use of renewable resources whilst These are just a few ways we demonstrate our commitment to continuing to expand our global business. As part of our com- the communities where we live, work and operate. Our goal is mitment toward sustainable development, we proactively seek to to establish long-term partnerships by focusing on projects that employ new, more sustainable technologies and processes. add lasting value to society at the global, regional and local levels.

20 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 21 Protecting the Environment (cont.) External Recognition

As a global player, Roche has the opportunity to reduce its impact Roche strives to implement the following strategy in its activi- Roche has been named to the CDP(4) A List, awarded as a CDP on climate. We have prioritised energy efficiency and renewable ties — avoid, reduce, reuse, recycle, thermally destroy. We permit Climate Disclosure Leader, and in 2015 Roche became an Indus- energy sourcing as two key ways to reduce our climate footprint. landfilling only as a last resort and, even then, only for inert ma- try Leader in Dow Jones Sustainability Index for the 7th consecu- Since 2010 a total of 1,063 energy-saving projects have been com- terials such as slag or incineration ash. Depending on the avail- tive year(5). Our efforts were also recognised by Newsweek, which pleted, yielding a reduction of approximately 127,000 tonnes of ability of suitable local waste-treatment plants, we may dispose of ranked Roche as the number 9 greenest company in the world’s Industry Leader CO2 emissions and an estimated cost saving of CHF 27.6 mil- non-hazardous general waste in authorised landfills. Roche does 500 largest publicly-traded companies (by market capitalisation) for the 7th consecutive year lion per year. Roche has also recently set a 10-year goal (2015– not accept landfilling of chemical waste or other hazardous ma- also in 2015. (According to Dow Jones Sustainability Index) 2025) to reduce energy intensity (gigajoule/employee) within our terials. In 2015 we set new goals for general and chemical waste owned facilities and purchased energy consumed by us by 15%. reduction: reduce general waste per employee by 10% over a five- By approximately 2050, we expect to reduce energy consumption year period and reduce landfilling of organic chemicals by 50% per employee by approximately 50%, compared to 2005 baseline over a five-year period. (4) CDP is formerly the Carbon Disclosure Project (5) Dow Jones Sustainability Indices: www.sustainability-indices.com/ levels. Additionally, we plan to increase the proportion of sustainable energy use to 20% by 2020. Operationally, Roche is compliant with all local and regional laws on environment, health, and safety and as such, we also focus on For the pharmaceutical industry globally, poor quality water is re- environmental responsibility, compliance, prevention and reduc- sulting in higher costs for purification and greater risk of product tion of occupational accidents and supply chain management as contamination. The demand for fresh water is increasing and an part of a broad commitment to corporate responsibility. In Safe- effective water management is crucial to avoid water scarcity. Our ty, Health and Environmental protection we employ 651 peo- aim is to protect water resources by reducing the amount of water ple worldwide and 491 people in Security. Expert teams at each consumption, recycling water where possible and purifying water Roche site identify risks and develop mitigation plans. to protect water quality. Our 2015–2020 water goal is to reduce consumption per employee by 10%, weighted according to the water stress for a respective region.

22 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 23 Watch video here Latin America

“Distinguishing health journalism means promoting quality information around a matter of fundamental importance for society.” Jaime Abello Banfi General Director of the Gabriel García Márquez Foundation for New Ibero-American Journalism (FNPI)

At FNPI we work to promote excellence in journalism, and to In this context, journalists play the key educational role of help- support the contribution reporters make to the development of ing generate a better understanding among the general public of countries across Latin America and the Caribbean. In this spirit, complex health issues, raising awareness, and guiding people to- since 2013 we have a collaboration project with Roche that con- wards better self-care for disease prevention. In this way, health sists of a health journalism award. In this effort, the FNPI func- journalists become drivers of value and benefits for society. tions as the technical secretariat, handling the entire process to ensure its professionalism and independence. The main goal of the Roche Award for Health Journalism is to contribute to communities across Latin America by recognizing The issue of health is increasingly important and complex. It is and promoting good journalistic practices and quality coverage no longer just about the traditional doctor-patient relationship, a of health topics. And at the same time, through workshops and merely medical or scientific issue. Today, people are evermore af- the broadcasting of distinguished works, the award also looks fected and concerned by healthcare, as it spreads across political, to open a space for discussion and knowledge-exchange, among social and economic dimensions. journalists and between them, experts and other key stakeholders. Above all, it is about driving attention and encouraging high-quality information around a matter of critical and increasing importance.

24 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 25 Roche Latin America São Paulo, Brazil 1930 at a Glance Headquarters Established

Women in Headcount Women Key Positions 4,328 50.5% 42.9% 2014 2014 2014 4,335 51.2% 42.8% 2015 2015 2015

Turn Over Rate New Hires Internal Hires 13% 695 237 2014 2014 2014 13.6% 617 207 2015 2015 2015 Hours of Training Total Hours of Training per Employee 53,882 12.4 2014 2014 96,123 22.2 2015 2015

Clinical Trials 2014 2015

Number of Clinical Studies 121 126 Environment 2014 2015

Energy Consumption (GJ) 493,097 512,104 Number of Active Sites 1,388 1,211

GHG Emissions (tons) 33,094 34,221 Number of Patients in Clinical Trials 4,677 3,751 Water Consumption (cubic meters) 74,317 117,456

General Waste Produced (tons) 460 425

Research & Development 2014 2015

Recycling (tons) 1,894 422 Investment in R&D (mCHF)(6) 97 89 Paper Consumption (tons) 1,382 93

Number of Employees in R&D 421 450 Investment in SHE (CHF)(7) 927,000 4,665,000 (Safety, Security, Health and Environment)

(6) Million Swiss francs (7) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

26 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 27 The region currently spends 7.6% of its gross domestic product on healthcare and this number is expected to increase 4.6% every year through 2018

Healthcare in Latin America

Latin America has experienced rapid and stable growth in recent years, resulting in increased healthcare spending in and government attention to programmes that improve access to healthcare. The region currently spends 7.6% of its gross domestic product on healthcare(8) and this number is expected to increase 4.6% every year through 2018.(9) Despite these investments, significant challenges remain, including a lack of infrastructure and trained professionals, low levels of education and awareness, affordability difficulties and disparities between local private and public healthcare systems.

Countries in Latin America vary widely on a number of factors that impact the healthcare landscape, including economic development, social and cultural standards, regulatory approaches, health infrastructure and perspectives on intellectual property. Healthcare treatments also vary greatly between the private and public healthcare sectors throughout Latin America. These dis- crepancies can be found across healthcare expenditures, income levels and levels of government funding in the region, and are particularly impactful for complex diseases like cancer.

As a result, the cancer mortality rate in Latin America is higher than that in the United States and Europe,(10) despite the region’s lower incidence rate. To address this issue, many countries are looking for new ways to sustainably increase access to healthcare.

(8) The Economist Intelligence Unit. Healthcare 2015 (9) Deloitte. 2015 Global Healthcare Outlook (10) Lancet Oncology 2013. Planning Cancer Control in Latin America and the Caribbean

28 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 29 Roche in Latin America Roche has been a Roche expanded to Latin America in 1930 with subsidiaries in dedicated partner with Buenos Aires, Argentina and Rio de Janeiro, Brazil. As of 2015, Roche Latin America operates in 23 countries with regional governments, physicians headquarters in São Paulo, Brazil, and owns two manufacturing plants in Mexico and Brazil. and patient associations Each country in Latin America faces unique healthcare challeng- in Latin America for es, and Roche’s commitment is as large and varied as the region itself. Roche has been a dedicated partner with governments, more than 80 years, and physicians and patient associations in Latin America for more than 80 years, and understands regional variations well. This understands regional experience helps us develop a nuanced approach based on local market conditions. variations well.

Roche’s presence in Latin America is characterised by a deep commitment to driving healthcare development and improvement. In 2014 and 2015, more than 200,000 patients across Lat- in America were treated with our strategic products in oncology and immunology. We are also one of the three fastest growing pharmaceutical companies. This growth is primarily driven by the increasing availability and demand for biological therapies. In the last two years, more than 50 Roche biological medications were approved in the region for a wide variety of diseases, ranging from the treatment of cervical cancer to the treatment of HER2-positive breast cancer. Roche embraces its responsibility as a leader in oncology and understands the unique challenges Latin America faces when it comes to cancer awareness, prevention, diagnosis and treatment.

30 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 31 Sustainability Initiatives

Access to Healthcare

Roche Latin America believes that every person who needs our to inadequacies in fundamental infrastructure, to political and products should be able to access and benefit from them. For this financial barriers. Roche takes a multi-stakeholder approach, to happen, several conditions need to be in place, including disease works to strengthen national cancer plans and partners within awareness, adequate healthcare infrastructure and sufficient medi- healthcare systems to increase access to tests and medicines. cal coverage. Roche is committed to tailoring solutions on a coun- Above all else, we work to elevate the patient voice to be sure our try-by-country basis to fit each country’s unique needs. most important stakeholders are heard. Through these activities, Roche supports the Group’s five primary pillars: Delivering In- In Latin America, Roche works with a variety of partners across novation, Increasing Disease Awareness, Strengthening Health- issues and geographies to ensure we are effectively addressing care Infrastructure, Improving Affordability and Supporting Lo- problems ranging from lack of disease awareness or diagnostics, cal Patient Organisations.

Delivering Innovation

As the population’s average age and life expectancy increase, de- Research and Development: mands on healthcare systems are growing exponentially. Health- In Latin America, Roche is developing an innovation network of care costs are rising and innovative medicines are expensive to independent research and development centres. Roche invested develop. At Roche we strive to provide our medicines to anyone 186 million CHF(11) in this network in 2014 and 2015, and has en- who needs them, so we work closely with healthcare authorities gaged 450 employees thus far. In addition to the results of the tri- and other stakeholders to develop solutions to bring our medi- als themselves, these efforts also benefit healthcare infrastructure cines to more patients. and expand medical training, leading to higher quality patient treatment in participating hospitals. To foster innovation, Roche partners with a diverse network of organisations in Latin America and around the world. In 2014- Clinical Trials: 2015 Roche Latin America was particularly focused on person- Roche Latin America developed 121 clinical studies in 2014, en- alised healthcare and biotechnology. gaging 1,388 sites and 4,677 patients. In 2015 Roche developed 126 studies across 1,211 sites that involved 3,751 patients. Personalised Healthcare: Roche is a global leader in personalised healthcare and is known In 2014 our clinical studies produced great insight into combina- for developing treatments that improve health standards and tion therapies. In HER2-positive metastatic breast cancer, a par- quality of life for patients. At present, approximately half of Roche ticularly aggressive form of the disease, we found unprecedented Latin America’s pharmaceutical projects are being developed in data on one drug, which, when combined with chemotherapy and parallel with diagnostic tests, leading to solutions that aim to fit another treatment, increased survival time for patients to almost the right treatment to the right patient. five years. Another study showed that when combining two drugs for advanced melanoma, the risk of the disease advancing was cut Biotechnology: in half. Roche now has over 30 different combination therapies in Biotechnology is fostering considerable advances in the treatment its oncology pipeline. of disease. Roche is currently the largest producer of medications in the biotechnology industry, with the most sophisticated bio- Since 2012 the U.S. Food and Drug Administration (FDA) has pharmaceutical production unit in the world that is responsible granted Breakthrough Therapy Designations to 12 indications of for roughly 25% of global biological production capacity. Roche medicines, four of them in 2015 alone.

(11) Swiss francs

32 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 33 Increasing Disease Awareness

At Roche, we recognize that raising awareness for health is just as important to a patient’s well-being as proper diagnosis and treatment. Greater public awareness of disease and symptoms can increase prevention rates and help patients receive early, accurate diagnoses. Throughout Latin America, we promoted and drove awareness in 2014 and 2015 for a variety of diseases including cancer, hepatitis, and cystic fibrosis, among others, across more than 170 awareness campaigns.

Cancer Awareness: To address high mortality rates for cancer across Latin America, Roche offices throughout the region create and support various awareness campaigns covering lymphoma, breast, ovarian, cervical, colorectal, and lung cancers. These campaigns are developed to meet the unique needs of each country and they aim to provide the public with proper information on prevention, early Roche Press Day: diagnosis and treatment options through websites, leaflets, con- As journalists play a vital role in disseminating and deepening ferences, forums, and the media. Beyond disseminating informa- public knowledge to increase awareness, prevention, and ear- tion, Roche also leads local activities that involve the community, ly diagnosis of critical illnesses, we developed Roche Press Day for example, local awareness walks to raise funds and awareness (RPD) in 2012. The event is hosted annually and seeks to pro- for a specific disease. mote knowledge exchange and continued education for many of today’s most serious diseases. Each year RPD brings togeth- Breast cancer awareness month in October is an area of strong er journalists from all over Latin America and expert panelists support across Roche Latin America and in addition to the activ- from around the world to discuss the latest scientific advances ities mentioned, during the month some offices light their build- and health-related issues and trends in the region. The event also ing pink to recognise patients and Roche’s commitment to the hosts the venue for recognizing the winners of the Roche Award fight against the disease. for Health Journalism. The award, organised by the Foundation for New Ibero-American Journalism (FNPI) and sponsored by Roche Latin America, honours and promotes high-quality health journalism.

Strengthening Healthcare Infrastructure Roche works to develop Latin America faces a variety of complex healthcare challenges, programmes that transfer ranging from lack of basic infrastructure and education for health professionals to gaps in public policy and healthcare regulation. information and skills to Roche aims to develop programmes that address these challenges by driving efficiency in healthcare systems, promoting accessibil- local partners. ity and supporting infrastructure improvements.

We believe sustainable solutions that meet the needs of the healthcare sector must go beyond traditional philanthropic models. Wherever possible, Roche works to develop programmes that transfer information and skills to local partners. With this in Diálogo Roche: mind, we aim to provide benefits across the entire value chain and This is the company’s official website for sharing scientific infor- focus our efforts on initiatives that strengthen education, boost lo- mation with healthcare professionals. It offers users relevant in- cal infrastructure, support quality medicine production and dis- formation on health issues, clinical studies, medical advances and tribution and reinforce public policies. We know success requires congresses, among others, to promote disease prevention. With collaboration, and we work in partnership with key stakeholders more than 46,000 registered physicians, the website is currently including the medical and scientific communities, governmental active in seven Latin American countries: Argentina, Brazil, Co- agencies, research centres and healthcare professionals. lombia, Mexico, Paraguay, Peru and Uruguay.

34 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 35 Supporting Local Patient Organisations

At Roche we recognise and support the great work being done by patient organisations to reduce barriers to healthcare and increase patient access. Here are a few examples of collaborative initiatives in this area:

“Patient Voices in Action”: Roche launched “Patient Voices in Action” in 2013 to help patient organisations improve their leadership, management and social action skills through an executive training programme in partnership with the Health and Aging Foundation of the Au- tonomous University of Barcelona. The first session was hosted in Panama in 2013 and followed by online learning modules throughout 2014, culminating in a final in-person meeting in Costa Rica during 2015.

The introductory training session provided participating organisations with a step-by-step itinerary for learning and practicing social action skills. In the following e-learning opportunities, the programme offered a “meeting point” for participants to discuss needs and future challenges and share experiences, while also offering knowledge and tools to improve their daily practices. Through the course, participants could build their capacity to communicate with healthcare and social agents and use resources in a more effective way.

A total of 36 patient organisations from 11 countries participated in the course, including: Argentina, Brazil, Chile, Colombia, Cos- Improving Affordability ta Rica, Ecuador, Mexico, Panama, Peru, Uruguay and Venezuela. Many of the organisations are dedicated to oncological patients Healthcare realities and challenges vary significantly across and Patient Access in Latin America: Governance, Assessment Organised by Roche Regional Market Access Latin America and and other pathologies, including hepatitis and transplants. within countries in Latin America. In recognition of these vari- Methodologies, and Evidence-Informed Decision Making in Global Health Policy teams in partnership with the Internation- ables, Roche prioritises flexibility and tailors all programming to Health Policy al Society For Pharmacoeconomics and Outcomes Research adapt to each market. We focus on the specific barriers to access Roche hosted a forum in 2015 that brought together 40 key stake- (ISPOR), the conversation aimed to ensure that all participants in each area, which can include a combination of socioeconomic holders to discuss governance principles and methodologies for involved have a good understanding of how evidence-informed factors, disease epidemiology, political commitment, healthcare reimbursement assessment decision-making in Latin America. decision making can improve overall health system performance, funding, health insurance coverage and the quality of healthcare The participants included government officials, health technolo- as well as the trade-offs in applying different approaches when infrastructure. Roche works alongside government agencies at gy assessment experts, patient group representatives, Roche rep- assessing the value of healthcare technologies and services for the national, state and municipal levels to support and promote resentatives, and other key stakeholders (for example, therapeutic specific interventions. responsive healthcare systems that address the specific needs of area experts, health economists and academics). the population and reduce barriers to healthcare access. Following the event, Roche received 100% positive feedback from participants, who expressed interest in further engagement on Roche’s approach to pricing also reflects the varying needs of each this important topic. Two-thirds of respondents also mentioned country in the Latin American region. Roche develops coun- that they view Roche as a credible voice on reimbursement as- try-specific agreements that align with local needs, policies and Roche prioritises sessment methodologies in Latin America. regulations. Currently we are piloting an assistance programme to provide pharmaceuticals to the public healthcare system at flexibility and tailors A follow-up webinar with participants, including stakeholders lower prices than market rate. Initially this pilot has focused on who could not participate in the forum due to other commit- cancer, hepatitis C and other chronic disease treatments. Roche all programming to ments, was scheduled for 2016 to ensure continued dialogue and also provides direct assistance programmes to subsidise payment strengthen relationships. options for patients who are unable to afford health insurance. adapt to each market.

36 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 37 In 2015 Roche Latin America provided a Employees total of 96,123 training At Roche we believe success is driven by employees motivated by a common purpose working in a culture of learning. Roche hours, which translates in Latin America is committed to creating a stimulating, partic- ipatory work environment and creates initiatives to build the ca- to 22.2 hours per pacity, engagement, health and well-being of our employees. We have invested in talent development, improved personnel man- employee. agement tools and policies, and offered training sessions on a variety of topics. In 2015 Roche Latin America was ranked among the best companies to work in the Great Place to Work® survey.

Roche Latin America currently employs 4,335 people, of whom 51% are women and 49% men. Among key leadership positions, 121 are filled by women, comprising 42% of total positions. Diversity and Inclusion: Roche Leadership is committed to seven principles: taking a genu- Roche is committed to maintaining an environment where every- ine interest in people; listening carefully, telling the truth, explain- one contributes to our mission of delivering innovative diagnosing ‘the why;’ empowering and trusting people to make decisions; tics and developing life-saving treatments, regardless of gender, discovering and developing the potential in people; striving for race, ethnicity, sexual preference or religious background. Diver- excellence and extraordinary results; setting priorities and simpli- sity is a top priority for us, and we want to foster a workplace fying work; and congratulating people for a job well done. Roche where diversity goes beyond visible differences to encompass a also provides resources and trainings for leadership development, variety of educational backgrounds, professional knowledge, as well as 360 degree feedback and performance management. personality types, thinking styles and life experiences. Emerg- In 2015 Roche Latin America provided a total of 96,123 training ing markets, like Latin America, are the most important growth hours, which translates to 22.2 hours per employee. driver for Roche in the next 5-10 years. As a result, Roche actively works to foster diverse leadership that represents the global Roche 2014 Global Employee Opinion Survey (GEOS): make-up of our portfolio and encourages best-practice sharing Our 2014 GEOS received an 80% employee engagement rate and across markets. Integrating a variety of perspectives is crucial to confirmed our talent management approach is on the right track. developing new medicines and access programmes to address the More than 80% of the employees surveyed said they would find it needs of customers and patients in Latin America and beyond. hard leaving the company and that they would recommend it to a friend seeking employment. Live Well at Roche: In 2013 Roche launched the global “Live well. Find your balance” According to the survey, Roche Latin America’s employees value programme, which includes a “Well-being week” for all employ- the daily work and responsibilities given to each individual; the ees. Hosted at more than 100 Roche locations worldwide, Roche feeling of accomplishment and the impact of their work; and are employees in all Latin American affiliates participated in Live proud to work at Roche because of its reputation in the market. Well events. Each location puts its own spin on the week, offering In 2015 Roche Latin The results of the survey were very positive, but we know we can unique programmes that promote health, relaxation, nutrition do even better. Each affiliate in Roche Latin America is working to and exercise. Activities range from yoga classes to cooking work- America was ranked implement programmes for continuous improvement. We deeply shops, massages, birthday celebrations and football matches. value our dialogue with employees and recognise it as an invalu- among the best able resource in our efforts to improve our business practices. companies to work In addition to our own employees, Roche is deeply committed to ethical employment across the entire region and supports pro- in the Great Place grammes to fight child labour, forced labour and modern slave labour practices in eight countries including Brazil, Nicaragua, to Work® survey. Honduras, Mexico, Guatemala, Dominican Republic, El Salvador and Costa Rica.

38 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 39 Governance We take our responsibilities Organisational Structure: Ethics and Transparency: The Roche Code of Conduct: seriously in order to meet The Roche Code of Conduct encompasses the Group’s Corporate The Latin American Leadership Team (LLT) is responsible for Roche’s primary objective is to meet patients’ and healthcare pro- Principles, as well as the policies and references that guide the high standards of business corporate governance and management to ensure business sus- fessionals’ needs for high-quality products and services. To meet conduct of all staff members in all regions where the company tainability in the short and long term, and is organised to foster this objective, Roche must identify needs and problems in health- operates. Employees are encouraged to seek guidance when in ethics and integrity. innovation and collaboration in an open and transparent manner. care and provide solutions. We take our responsibilities seriously doubt about the correct way to proceed in business, and to re- This culture allows Roche to learn from both success and failure in order to meet high standards of business ethics and integri- port cases of possible issues involving compliance and ethics. The and set meaningful goals for the future. ty. This is instrumental to our sustainable success, and hence to code also addresses situations of conflict of interest that must be our ability to make a lasting impact on public health. Integrity at reported by executives. To help employees, the company has a Roche means doing things right from the start. speak-up line to report potential compliance violations. Executive Committees: Each country within Roche Latin America has an Executive Committee, comprised of the Our commitment includes full respect for patients’ individual Supplier Engagement Programme: country president, executives, and managers, that reports rights. We also build respect for the individual into all our work Roche’s goal is to be one of the top three companies in sustain- In Latin America we have conducted 140 supplier audits in the to the regional Head. The purpose of this committee is to and for all members of the organisation, and apply our Corporate ability in the health industry. To achieve this, Roche needs a sup- last two years to ensure compliance with Roche and industry ensure responsible management and organisational align- Principles in our relations with business partners. We are comply chain that supports and implements these same principles. codes and standards. All of our suppliers also receive training on ment between each country affiliate and the Group. In cer- mitted to maintaining high ethical and social standards in our To this end, the company has maintained a Code of Conduct for our Code of Conduct and have to accept it in order to be one of tain countries, such as Brazil, Roche also has Compliance business dealings, in our approach to medical science, and in our Suppliers since 2010 and expects every company or profession- our business partners. Suppliers who exceed expectations are also and Sustainability Committees, which specifically address efforts to protect the environment and ensure good citizenship. al maintaining commercial relations with Roche to comply with recognized by Roche Latin America for their outstanding service relevant issues in the country. We are committed to innovation and benchmarking our prin- this Code of Conduct. The Code provides guidance for suppliers as encouragement for all suppliers to perform their best. ciples and achievements against the industry and best practice, on issues relating to sustainability with emphasis on its impor- which includes transparent reporting. tance to Roche. Through the Code, the company requires its suppliers to adhere to specific sustainability principles: ethics, employment, health and safety, environment, management systems, innovation, economic sustainability, and diversity of suppliers.

40 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 41 Environment

Roche is committed to sustainable development and making safety, health and environmental protection (SHE) an integral part of its operations. Throughout 2014 and 2015 Roche invested nearly 5.6 million CHF in SHE across the Latin American region. In doing so, Roche concentrates on responsible resource use and technologies that minimise environmental impacts. Roche’s efforts to protect the environment focus on the following pillars:

• Prevention: promote employee engagement in responsibility, safety and environmental protection through education, awareness and training campaigns.

• Shrinking the ecological footprint: introducing new technologies and sustainable processes to minimise the environmental impact of all our operations.

• Environmental balance: reducing environmental impact per employee, with the goal of a 15% reduction by 2020, with a 2010 baseline.

• Cutting energy use: reducing energy consumption and CO2 emissions by 20% per employee by 2020, with a 2010 baseline.

Results for 2014-2015: The Roche Group values eco-efficiency, which optimises- re source use to reduce negative environmental impacts. To achieve Communities this, the company focuses on cutting material and energy consumption in its processes, reducing waste generation and using Roche is deeply committed to the communities where we oper- Roche Children’s Walk: renewable resources. The Group quantifies progress using the ate. In Latin America, community initiatives focus on three pil- The Roche Children’s Walk is a global employee fundraiser that Eco-Efficiency Rate (EER), created by the company itself, which lars – childhood, education, and the local neighbourhood - and raises contributions for the children of Malawi, Africa. In Mala- compares group sales to the expenditures and environmental are spearheaded by leadership at each of our 10 affiliates. This wi, 62% of the local population lives below the poverty line and impacts required to produce its products. This makes it possi- local approach allows us to tailor our activities more effectively to many of the children are orphaned due to HIV/AIDS. The funds ble to evaluate efficiency concretely, so that an increase in sales support the actual needs of our communities. raised for these children help to foster long-term sustainable combined with a reduction in costs and environmental impact change by providing food, education, practical skills training demonstrates greater process efficiency. and health promotion. Waste: Roche Children’s Walk takes place every year on June 16, the In- Roche monitors the waste it discharges at treatment facilities. ternational Day of the African Child, and has raised more than Overall Roche eliminates 90% of pollutants – an excellent result 12.5 million CHF to date, supported by more than 150,000 em- for the industry. The company does not discharge any environ- With record participation, ployees at 130 Roche sites around the world. There was record mentally significant metals such as cadmium or mercury. Throughout 2014 and participation in 2015, with 19,000 employees raising approxi- Roche Children’s Walk mately 1.3 million CHF, which Roche then matched to double the Energy and GHG Emissions: 2015 Roche invested charitable contributions. The Roche Group continuously strives to reduce its energy con- raised nearly 1.3 million sumption, and supports the greenhouse gas (GHG) emissions nearly 5.6 million CHF Local affiliates can use up to 50% of the funds raised for proj- reduction targets set forth in the Kyoto Protocol. GHG emis- CHF in 2015 to help ects supporting local children; the balance goes to support global sions at Roche originate mostly from our energy use. There- in SHE across the Latin programmes, including Roche’s long-standing philanthropic rela- fore, we set a goal to reduce our energy use by 20%, measured children in need. tionship with schools and orphanages in Malawi. in tons per employee, by 2020 with a 2010 baseline. We expect American region. to achieve further reductions by switching from fossil fuel to renewable energy sources.

42 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 43 Watch video here Argentina

“A company is sustainable when it looks towards the f u t u r e .”

For me, Roche is much more than the company I work for, it is Luis Cresta part of my life. The same year I got married I also joined the com- Technical Director at Roche Argentina pany. It has been 31 years now, more than half of my life.

I love sports, and enjoy practicing many myself. I like running, mountain trekking and diving. I am also passionate about na- ture and the outdoors, and very committed to the environment. That is why I am proud to lead the area of Health, Safety and Environmental Protection, where we work to ensure the safety Even the headquarters office space where we work every day, the and health of our colleagues, and also care for the environment. Pacheco building, was designed to have a minimal environmen- We have many initiatives that look to protect the environment. tal impact. So, for instance, it maximizes the use of natural light On some of them we have been working for several years, such to reduce energy consumption, and has automatic systems for a as our programme for the rational use of energy. With it we try better management of heating and air conditioning. to reduce our energy consumption and use renewable sources whenever possible. We also have a global project to convert or In the many years I have been at Roche, I have had the opportuni- replace the devices that operate with gases that affect the ozone ty to witness how it has transformed, evolving over time. So I can layer. And to avoid electronic waste, we recycle or reuse most of say that innovation is not only in the products we make but also our equipment. in the way we do things.

44 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 45 Roche Argentina at a Glance Buenos Aires 1930 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 407 43.7% 35% 7.9% 2014 2014 2014 2014 421 43.9% 30.4% 7.2% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 33 19 5,447 7.7 2014 2014 2014 2014 49 16 7,925 11.5 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 63 63 Investment in R&D (mCHF)(12) 6 12

Number of Active Sites 250 200 Number of Employees in R&D 36 63 Healthcare in Argentina Roche in Argentina

(12) Million Swiss francs Number of Patients 874 598 Healthcare in Argentina is viewed as a right for all citizens. Access Headquartered in Buenos Aires, Roche has been present in Ar- in Clinical Trials is granted though public government programmes and, accord- gentina since 1930. Roche Argentina has remained in the top ing to the Ministry of Health, 51.5% of the Argentine population three laboratories in the country during this time and is currently is currently covered by social security. Federal laws state that all ranked as third. We seek not only to bring value to society by pro- Environment 2014 2015 patients are entitled to receive 100% coverage for the treatment of viding innovative solutions in the field of health, but also to act as pathologies, such as cancer, transplants and HIV/AIDS. a responsible taxpayer, a supportive employer and an investor in Energy Consumption (GJ) 26,926 71,428 our local communities. However, budget constraints have limited health coverage re- gimes and have led to the rejection of some requested treatments. Roche Argentina observed 15 products dominating sales in 2014 GHG Emissions (tons) 2,391 5,647 As such, nearly 11% of the population opts for private healthcare and 2015, highlighting a strong focus on oncology. Research and coverage, an option that is reserved for the relatively prosperous, trials during this time also led to regulatory approval for 10 new Water Consumption (cubic meters) 1,946 386 to guarantee treatment if they become critically ill. This has led products covering diseases such as: to the development of a healthcare gap impacting low-income households in Argentina that cannot afford care through the pri- • Polyarticular juvenile idiopathic arthritis General Waste Produced (tons) 101 87 vate system. • Cervical cancer • Platinum-resistant recurrent ovarian cancer Recycling (tons) 30 48 This situation has led to an increase in undetected health prob- • Basal cell carcinoma lems, especially among low-income families. For example, can- • Non-Hodgkin lymphoma cers that typically have high survival rates are often not identi- • Metastatic and early breast cancer Paper Consumption (tons) 11 47 fied and treated until a late stage, which significantly reduces life • Rheumatoid arthritis expectancy, even with proper treatment. There is a great need to Investment in SHE (CHF)(13) 48,000 105,000 work with families who are not able to access healthcare regularly (Safety, Security, Health and Environment) to provide treatment, as well as education on disease prevention (13) Investment ﬁgures in Swiss francs and also include the Diagnostics Division and the recognition of early symptoms.

46 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 47 Innovation is vital to Roche Argentina’s creation and development of medicines and treatments that meet people’s health needs and improve their quality of life.

Sustainability Initiatives Access to Healthcare

Roche Argentina is focused on helping all citizens acquire the healthcare and treatment that they need. Through persistent commitment and collaboration with stakeholders, Roche finds equitable and sustainable solutions to the barriers in healthcare through activities that focus on the Group’s five main pillars: De- livering Innovation, Increasing Disease Awareness, Strengthen- ing Healthcare Infrastructure, Improving Affordability and Sup- porting Local Patient Organisations.

Delivering Innovation

Innovation is vital to Roche Argentina’s creation and development of medicines and treatments that meet people’s health needs and improve their quality of life. At Roche we explore ideas, face setbacks and relentlessly pursue new approaches to make true advances against disease. Throughout this process, our people remain dedicated to transforming science into breakthrough medicines and diagnostics.

In 2014 Roche Argentina led 63 studies through its clinical research unit across 250 sites, supporting 874 patients for areas including oncology, rheumatoid arthritis, respiratory disease, ophthalmology, Alzheimer’s, Crohn’s disease and influenza, among Roche Argentina is focused on helping others. Roche Argentina continued studies in these areas during 2015, in 63 trials across 200 sites and involving 598 patients, all citizens acquire the healthcare and with a total investment of 154,216,804 ARS(14) on clinical studies during these two years. treatment that they need. Roche Argentina also provides support to the Angel Roffo Oncol- ogy Institute by maintaining their cyber room, offering medical research information and providing opportunities for hospital professionals to receive training.

(14) Argentine peso

48 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 49 Roche Argentina has received 10 Eikon Awards since 2006, a prestigious distinction granted by the magazine Image.

Increasing Disease Awareness

Awareness and education around disease can be as important • Arthritis: To help develop stronger patient-doctor communi- to a patient’s well-being as proper diagnosis and treatment. cations, Roche Argentina partnered with the non-governmen- Throughout 2014 and 2015 Roche provided information regard- tal organisations AMAR and AAPAYER to organise a meeting ing disease prevention, symptoms and available treatments in for 130 rheumatoid arthritis patients in 2014 that included a total of 14 campaigns. For these and other communications recreational activities and informative discussions. The con- efforts, Roche Argentina has received 10 Eikon Awards since versation focused on good nutrition, exercise, the importance 2006, a prestigious distinction granted by the magazine Image. of a multidisciplinary treatment and how patients can best prepare for their visit with healthcare practitioners. Roche also Sample initiatives driving disease awareness in 2014 and held an event in both 2014 and 2015 with Pedro Elizalde Hos- 2015 include: pital, where over 300 juvenile idiopathic arthritis patients and families had the opportunity to learn more about the disease • Gynaecologic cancers: Throughout ovarian cancer aware- through various recreational activities and parents/caregivers ness month in March, Roche Argentina worked in partner- shared experiences on how to accompany their kids through- ship with the patient organisations ACILCO and ACIAPO to out the course of treatment. drive awareness around the disease, stressing in particular the importance of early detection; between 2014 and 2015 these • Breast cancer: Throughout breast cancer awareness month in efforts reached more than 20 million people. In January 2015 October, Roche promoted education materials around early Roche promoted awareness for cervical cancer and human detection and treatment options for HER2-positive metastatic papillomavirus (HPV) by distributing educational materials breast cancer patients. Roche also supported activities hap- on symptoms, incidence, prevention and screening, as well as pening during the month in partnership with the NGO MAC- on recent progress against the disease in terms of diagnosis MA to drive community involvement. and new treatments available. Through this awareness effort, we reached more than 28 million people in the country. • Lung cancer: Roche Argentina helped the dissemination of information around lung cancer, stressing in particular causes • Colorectal cancer: Roche Argentina conducted a series of in- beyond tobacco and the importance of regular check-ups. terviews with experts to educate the general public on colorectal cancer and the different therapies available, reaching more • Hepatitis: On World Hepatitis Day, Roche supported an than nine million people throughout World Colorectal Cancer awareness campaign of the NGO HCV Without Borders Awareness Month in 2015. across 10 provinces in Argentina to expose common misconceptions and drive deeper education about the disease, partic- • Lymphoma: To drive awareness around lymphoma, Roche ularly among patients without healthcare coverage. Argentina supported the public campaign and efforts of the local patient organisation Lymphomas Argentina, reaching between 2014 and 2015 more than 50 million people with information that exposed common misconceptions about early detection, symptoms, and available treatments.

50 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 51 Supporting Local Patient Organisations

Roche Argentina supports patient organisations in order to improve access to healthcare for the local population.

A few highlights in this area include:

• ACIAPO Foundation: Helps patients navigate a complex healthcare system in public hospitals where bureaucracy ob- structs patients from its treatments. They also work in early detection campaigns, organise trainings for primary care physicians by hospital medical oncologists and provide information to patients of cancers with the highest incidence (symptoms and risk factors).

• Tzedakah Foundation Campaign for Women’s Health: Roche supports this campaign aimed at raising awareness and improving care, diagnosis and treatment of gynaecological health conditions for women of low-income and/or rural areas that have difficulty accessing the healthcare system. The -cam paign’s goal is to move women from areas of high vulnerabil- ity to care centres where they perform gynaecological exams. Tzedakah assistants accompany them during their treatments.

• APAT Foundation: Roche Argentina supports the Founda- tion, which takes care of transplant patients and their families. The foundation visits infusion centres’ transplant patients, delivers information materials on care and healthy living and sends a newsletter about the pathology, personal care and patient rights.

Strengthening Healthcare Infrastructure Improving Affordability

Roche Argentina helps break down barriers to healthcare ac- To help Argentineans overcome obstacles and access the health- In 2015 Roche Argentina participated in a pilot programme for cess by improving medical education and professional training. care they need, Roche adapts its strategy to the realities and com- a new global initiative, “Personalised Reimbursement Models” Throughout 2014 and 2015 Roche conducted 50 initiatives and plexities of the local market, where specific needs and barriers (PRM), to increase treatment affordability. The programme aims hosted 3,489 attendees for healthcare practitioner trainings and depend on income levels, disease epidemiology, political com- to move treatment pricing from a volume-based model to val- medical education activities. mitment and resources allocated to health, as well as insurance ue-based model in which reimbursement can vary depending Throughout 2014 and coverage and the quality of healthcare infrastructure. on the indication or the combination of the medicines needed in Roche also hosts “Diálogo Roche,” a website that offers physicians order to ultimately increase the availability of innovative medi- 2015 Roche conducted and other healthcare professionals relevant information on health In order to address affordability issues, Roche Argentina con- cal treatments. Through the programme, local Roche leadership issues, clinical trials, medical advances and congresses, among ducts the “Shared Risk” programme in partnership with various works closely with external stakeholders and discusses preferred 50 initiatives and hosted others, to promote disease prevention. medical insurers. The programme aims to facilitate reimburse- business partners to execute the programme and move PRM to a ment for arthritis patients. In the first two to three months of national level. 3,489 attendees for In 2015 Roche Argentina hosted the “First Interdisciplinary Vas- treatment, Roche provides the medicine free of charge so that its culitis Workshop,” which brought together the Argentine Society effectiveness can be assessed. If the treatment has no effect on the healthcare practitioner of Rheumatology (SAR), the Nephrology Association of Buenos patient, it is then discontinued with no charge to the social benefit Aires (ANBA) and the Argentine Association of Respiratory Med- programme. If there is a positive response to the medication, then trainings and medical icine (AAMR) for the first time. The workshop was attended by Roche offers special financial terms for the patient to complete more than 100 physicians and addressed vasculitis from an inter- the treatment. education activities. disciplinary perspective and major advances against the disease in recent years.

52 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 53 Employees

The success of Roche is based on its collaborators, who, talented Roche Argentina also offers many employee benefits including: and highly skilled, continually demonstrate their professionalism, healthcare covered 100% by Roche, additional holidays, cafeteria commitment, experience and vision both inside and outside the 100% covered by Roche, childcare, new parental flexibility pro- company, to drive innovation and improve the quality of health grammes, Flex Friday (early leave) in summer and wellness op- care. At Roche we strive to develop a stimulating and engaging portunities, among others. work environment that benefits the well-being of our employees. At present, Roche Argentina employs 421 people, of whom al- As family time is very important for our employees, Roche has most 44% are women and 56% are men. developed extensive parent programmes that provide additional support. For example, the local office provides access to childcare, Roche promotes a diverse and inclusive workplace, and our focus kindergarten and various summer camps that employees’ chil- in Argentina is on effectively integrating multiple generations, as dren are able to attend during work hours. Through the “Mothers well as diverse backgrounds and perspectives. During 2015 we @ Roche” programme, new parents also have the opportunity to have performed diversity and inclusion workshops at different extend maternity leave and participate in a gradual return to work levels of the organisation. In addition, we foster internships with programme that offers the option to work remotely from home. students from various universities to incorporate younger gener- In 2014 Roche Argentina won the “Towards a Family-Respon- ations into the workplace. sible Company” award by the non-profit organisation Parents’ Foundation for promoting work-life balance among employees. In 2015 Roche Argentina ranked fifth within our size segment in Apertura magazine’s “Best Employers,” and also received top Connecting family with business, we have successfully intro- positions in MERCO’s corporate reputation, management and duced a “Fellows Programme,” an initiative to offer six-month talent rankings. internship opportunities to the children of Roche employees who are between 18 and 23 years-old and studying at the university. In 2015 Roche Argentina With a score of 67% in the last Global Employee Opinion Survey (GEOS), Roche Argentina has obtained an engagement level in ranked fifth within our the optimal range across the survey’s three editions, with high response rates as high as 95%. This score is significantly higher than size segment in Apertura the average score of other Argentinian companies applying similar engagement models. Internal feedback has been overly positive in magazine’s “Best Employers.” areas such as physical work environment, co-workers, work tasks and diversity. Constructive feedback highlighted areas that we have been working on to improve such as pay and recognition.

54 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 55 Governance Communities

In accordance with the Group’s guidelines on Corporate Gover- Roche is committed to being a great partner to each and every nance and Code of Conduct, Roche Argentina follows all compa- community we are located in. Through various engagements, we ny policies on corporate behaviour and ensures that all employees aim to establish long-term partnerships that add lasting value to and business managers act in accordance with the company’s eth- the community, with an emphasis on access to high-quality edu- ical principles when carrying out their duties. Throughout 2014 cation. We focus on several aspects of community advancement and 2015 Roche Argentina offered seven employee trainings on including programmes for: topics such as grants, interactions with healthcare practitioners, compliance induction and integrity in business. • Supporting humanitarian and social needs

In order to ensure that our suppliers are also aligned with corpo- • Expanding science and education rate policies, Roche Argentina conducted five supplier audits in each year of 2014 and 2015, and offered two supplier trainings. • Encouraging the arts and culture

Roche has also been a pioneer in anti-counterfeiting measures in • Maintaining a safe and healthy community and environment Argentina, making continuous improvements to the Roche se- rialisation system, most recently moving from a traditional bar Some community programmes for Roche Argentina include: code to a bi-dimensional code that has helped increase logistical and physical security measures. These advances have dramatical- • Support for the NGO Tunas’ programme: This effort focuses ly reduced the counterfeits detected in Argentina by Roche and on access to trainings for adolescents and kids in low-income since 2011, all incoming counterfeited units have been success- communities to help build various skills, ultimately helping fully identified. them become active citizens in society. Hundreds of local children attend these workshops and participate in educational activities outside their schooling, especially in the arts. Roche Argentina makes at least one annual donation; in 2015 we donated 2,500 ARS, benefitting 50 people.

• Teach for Argentina: As an initiative that addresses education inequality in the region by partnering with teachers to help students access high-quality education, support for our local programme benefits teachers working in a vulnerable school within the district of Tigre, where our offices are located. In In order to ensure that 2015 Roche was able to benefit 100 individuals through a donation of 71,500 ARS. our suppliers are also • Work with Maria of Guadalupe School: This school provides aligned with corporate support and training for local new teachers in social science with the objective of expanding teaching in areas such as his- policies, Roche Argentina tory and geography. The programme focuses on increasing digital learning and educational trips outside the classroom. conducted five supplier Our 2015 donation of 87,700 ARS reached 300 students. audits in each year of 2014 and 2015, and offered two supplier trainings.

56 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 57 Watch video here Brazil

I am a physician by training and strongly support the cause of “When a company allows health. That is why I was excited to participate in a volunteerism programme we organised with the NGO Health and Joy (SAS), its employees to truly live to give people in remote areas access to medical check-ups. The Environment expedition took us to the middle of Bahia’s wilderness, where we its purpose, first-hand, it did not even know how we would eat or sleep. The reduction of Roche Argentina’s environmental impact has Noteworthy programme achievements include: is a unique experience.” continued through an investment in Roche’s Energy Efficiency I am grateful for this experience because it changed my life, made Plan, which focuses on habitat conservation, efficient use of re- • Discontinuation of substances with a high depleting effect on me different. When you are able to put things in perspective, ev- Claudio Lisondo sources and responsible waste disposal. These programmes ac- the ozone layer. Select equipment and gases were replaced by erything changes. We work so hard for patients’ health, putting Medical Manager at Roche Brazil tively support the reduction of our overall ecological footprint less polluting substances such as HFC refrigerants. Our efforts them at the centre of everything we do. And then you go out and as well as optimise the use of renewable and non-renewable re- have resulted in a 63% reduction of ozone depleting gases. realize that for the patient it is not just a medical issue, of seeing a sources, enhancing safety, health and environmental protection. doctor for a check-up. It is about support, having someone there In 2015 Roche was recognised for the seventh consecutive year • Reduced energy consumption through LED technology up- to talk to and who can listen to them. as the most sustainable company in Argentina by the Dow Jones grades on our building lighting and the automation of turn Sustainability Index. on/off mechanics for high consumption equipment, among My main takeaway from this experience is that sometimes small With this volunteer activity, I completely left my comfort zone, other activities. Overall we were able to reduce general waste actions can make a huge difference in the lives of patients. For pushed the limits of my resilience and persistence. And what disposal by 14%. instance, there was a lady with rheumatoid arthritis, who took a made the experience even more enriching was that I went through 4.5-hour bus ride to get to our station because she had never seen it together with other colleagues with whom I share a common • Continued efforts in our “Wastes of Electrical and Electronic a doctor. She had a deformity in her hands and thought that it purpose. That is why I feel so proud about working here. Equipment” (WEEs) initiative launched in 2013, which aims was normal. To see her realize that there is a treatment for what to increase the reuse and recycling of hazardous materials she had, and that she did not have to live in pain, that was truly such as electronics. In its first year the programme increased rewarding. And all it took was for us to talk to her and explain equipment reuse/recycling by 60%. what was happening.

58 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 59 Roche Brazil at a Glance São Paulo 1931 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 1,167 50.2% 48.7% 13.3% 2014 2014 2014 2014 1,161 51.2% 48% 11.2% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 150 161 9,429 8.1 2014 2014 2014 2014 120 99 35,074 30.2 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 72 72 Investment in R&D (mCHF)(15) 36 28

Number of Active Sites 424 371 Number of Employees in R&D 111 110 Healthcare in Brazil Roche in Brazil

(15) Million Swiss francs Number of Patients 1,538 1,127 With a population of nearly 200 million, Brazil provides health- With its Latin American administrative headquarters in São Pau- in Clinical Trials care to all citizens through the country’s public healthcare system lo, Roche has been present in Brazil since 1931. In 2015 Roche (SUS). As part of this system, more than 500 types of standardised announced an investment of almost 100 million USD(17) over the treatments are available at no cost in the field of oncology, ra- next five years to expand its manufacturing facility in Rio de Ja- Environment 2014 2015 diotherapy, chemotherapy and hormonal therapy treatments for neiro. The medicines produced in this facility are exported to 23 cancer. countries in Latin America and Europe. Energy Consumption (GJ) 157,453 137,837 However, Brazil faces the complexities of a vast geo-social terri- Roche Brazil collaborates with the Ministry of Health and the Na- tory. Due to the diverse array of social, cultural, environmental tional Health Surveillance Agency who are responsible for pub- GHG Emissions (tons) 7,374 5,953 and economic factors, not all citizens are able to access healthcare lic health management in Brazil, as well as the National Health offered under the public system. As such, cancer – specifically Agency, which regulates the health insurance companies in the Water Consumption (cubic meters) 21,104 35,477 breast cancer – mortality remains high because many cases are country. These partnerships help advance the registration of new not diagnosed until the advanced stages of the disease. products, expand medical use and new indications, ensure the procurement of drugs and diagnostic tests for hospitals and pub- General Waste Produced (tons) 326 289 The Brazilian government and the National Cancer Institute to- lic laboratories, and move forward public policy discussions in gether with non-governmental organisations (NGOs) and the the field of health. Recycling (tons) 223 140 media have planned campaigns seeking to reach and educate a larger number of people about cancer, while also investing more The inclusion of Roche medicines under SUS have been increas- in training and professional services. ing; through negotiations with the Ministry of Health, the public Paper Consumption (tons) 30 16 sector represents 20% of the Group’s results in Brazil. In 2014 the Pharmaceuticals Division obtained approvals on 14 new product Investment in SHE (CHF)(16) 392,000 58,000 applications; additionally, nine Roche medicines are covered un- (Safety, Security, Health and Environment) der Brazil’s public health system. (16) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

(17) United States dollars

60 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 61 Roche works with over 200 research centres in Brazil.

Sustainability Initiatives Access to Healthcare

Roche is focused on ensuring that people who need access to the benefits of complete and innovative treatments with quality medicines are able to obtain them. As such, Roche Brazil aims to break down the barriers in healthcare across five main areas: Delivering Innovation, Increasing Disease Awareness, Strength- ening Healthcare Infrastructure, Improving Affordability and Supporting Local Patient Organisations.

Delivering Innovation

Roche’s primary goal is to create and develop medications and diagnostics that improve people’s quality of life, and innovation is a key factor to achieving this goal. Roche works with over 200 research centres in Brazil and has invested over 112 million BRL(18) in clinical trials and 64 million CHF(19) in research and development. In 2014 Roche Brazil led 72 clinical studies across 424 sites involving 1,538 patients with a focus on breast cancer, multiple sclerosis, lymphoma, chronic lymphocytic leukaemia and others. In 2015 Roche continued research in these areas and supported 72 clinical trials across 371 sites involving 1,127 patients.

(18) Brazilian real (19) Swiss francs

62 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 63 Roche Brazil supported a total of 10 awareness campaigns throughout 2014 and 2015.

Increasing Disease Awareness

At Roche we recognise that raising awareness for health is just as important to a patient’s well-being as proper diagnosis and treatment. Greater public awareness of disease and symptoms can increase prevention rates and help patients receive an early diagnosis. Throughout 2014 and 2015, Roche Brazil supported • “Walk for Life” campaign: In support of 2015’s breast cancer a total of 10 awareness campaigns covering hepatitis C, cystic awareness month, Roche sponsored the seventh edition of a fibrosis, rheumatoid arthritis and a variety of cancers. Some of walk for breast cancer in Porto Alegre, where 400 locals came these initiatives included: together to drive awareness for prevention and early diagnosis of the disease. • “Conscious Woman” campaign: In the context of 2014’s breast cancer awareness month and São Paulo Fashion week, Roche • “For more Time” campaign: In order to raise awareness for collaborated with Brazilian fashion designers Amapô and metastatic breast cancer and the difficulties patients face -ac Ronaldo Fraga to create special pink scarves for breast cancer cessing treatment, Roche worked with the patient organisa- awareness. Roche also hosted a press event in partnership with tions Femama and Oncoguia, as well as 15 celebrities, to en- the publisher Globo and the NGO Oncoguia to drive aware- courage people to think about what would happen if their time ness for the cause, launched the “Conscious Woman” website on earth was cut short. Roche also hosted an awareness event with information about breast cancer, and conducted pink at the São Paulo Art Museum and shared information about lighting and other local activities for the campaign. the disease through the campaign website, social media and influencers, with a total reach of over 24.5 million people.

64 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 65 Supporting Local Patient Organisations

Recognising the great work achieved by patient organisations, Roche Brazil collaborated with close to 50 different organisations to transform healthcare in the country during 2014 and 2015. In the selection of these partnerships, Roche developed new guidelines in 2014 to ensure that all collaborations are transparent and provide synergy with Roche’s core values.

In 2014 Roche Brazil supported 44 patient groups and at least 35 in the following year with total financial contributions of over 5.8 million BRL. A sample of the initiatives created with patient organisations included:

• Collaboration with 26 representatives from eight cystic fibrosis patient organisations and five rheumatoid arthritis patient associations to develop a basic management capacity programme that addresses specialty care for patients. This programme has generated much credibility and has become a reference for other similar activities.

• Partnership with 22 patient associations in oncology and rheumatoid arthritis from 10 different states in Brazil to ignite conversations around meeting patients’ needs and opportunities to strengthen the healthcare network. Activities also focused on building a comprehensive training programme for patient organisations to attend, split into three levels: basic, in- termediate (advocacy essentials) and advanced (specialisation in public policy and other specific themes).

• “All Together against Cancer,” a campaign that aims to establish a national coalition that discusses the main challenges and hurdles in oncology. Developed in partnership with the Bra- zilian Association of Lymphoma and Leukaemia (ABRALE), the campaign has helped foster a professional network that discusses and advocates for oncology priorities and treatment guidelines. It also promotes relevant discussions around needs Strengthening Healthcare Infrastructure Improving Affordability in this area and identifies opportunities for collaborative initiatives that address current policy issues surrounding oncology. In order to improve healthcare access for all Brazilians, Roche de- Addressing a variety of healthcare needs, Roche adapts its strate- Many of Roche’s patient support programmes in Brazil also look velops numerous programmes that deal with the specific barriers gy to the complexities of each market, which may vary depending to improve affordability. Some examples include: to healthcare across basic infrastructure, medical education and on income levels, disease epidemiology, political commitment professional training in Brazil. and resources allocated to health. • “Inspire,” an initiative that helps patients with cystic fibrosis acquire the inhalers they need for treatment. In 2014 Roche Roche’s medical education programmes trained over 3,800 par- Recognising a need for public healthcare programmes to in- invested 520,000 BRL to distribute 472 nebulizers. ticipants in 2014 to help healthcare professionals gain access to crease supplies of approved treatments, Roche established the In 2014 and 2015, Roche resources that provide proper diagnoses and treatment to pa- “Regionalisation Access Programme” to expand and expedite • “Relate-RA,” an initiative that helps enable people with rheu- tients, ultimately improving access to healthcare. access. The programme’s approach allows for a faster inclusion matoid arthritis to receive proper treatment. In 2014 Roche Brazil collaborated with of medicines into the public healthcare system as compared invested 2.1 million BRL to benefit 1,929 patients. The website Diálogo“ Roche” is an online resource for physicians with country-focused negotiations. Roche Brazil was the first close to 50 different and other healthcare professionals that offers relevant informa- pharmaceutical company in the country to apply a customised tion on health issues, clinical studies, medical advances and con- strategic approach to the State Healthcare Agencies and this organisations to transform gresses, among others, to promote disease prevention. programme has opened the door for productive discussions to improve healthcare in the region. healthcare in the country.

66 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 67 Employees

Roche Brazil currently employs 1,161 people, of which 51% are • “Playing to Know,” an event where employees could bring their women and 49% are men. Roche believes that educated, engaged children into the office so they could take part in their parents’ and motivated individuals are essential to the success of its strat- daily work routine and see where they work. egies; in Brazil, Roche invests heavily in employees to create a healthy and stimulating environment. • A flexibility package that includes flex-time, bus charters, gym membership and summer Fridays, allows employees to main- Roche Brazil employee benefits include meal and grocery allow- tain a productive work schedule and meet their personal needs ance, complete healthcare, financial assistance, childcare oppor- and quality of life goals. tunities and various wellness programmes, among others. Sample employee initiatives that were active in 2014-2015 include: In 2014 the magazine VOCÊ S/A ranked Roche Brazil among the Best Places to Launch a Career, making Roche the first pharma- • Career workshops to encourage employees to think about their ceutical company in Brazil to appear in this ranking. The publish- career expectations, advance their skillsets and follow a devel- er Gestão RH also ranked Roche among the top 10 Companies in opment plan. A series of workshops were hosted throughout its Organisational Human Development Index, as well as among In 2014 the magazine 2015 with 100 employees participating. the best in People Management Practices. For the fourth time in 2015, Roche Brazil was rated among the best workplaces in the VOCÊ S/A ranked • “Wellness Week,” as part of Roche’s “Live Well. Find your country by the Great Place to Work® Institute, and among the Balance” programme, aims to create a culture of health and “Biggest and Best” companies in the health sector by the maga- Roche Brazil among well-being among employees through activities around zine Exame. healthy lifestyle, disease prevention and emotional well-being, the Best Places to among others. The week provided opportunities for reflection, self-knowledge and, above all, for healthy lifestyle practices. Launch a Career. Throughout the initiative, close to 800 employees participated in the different activities.

68 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 69 Governance Communities

Roche Brazil follows the Group’s Code of Conduct and has adopt- At Roche we have been investing in the communities in which ed transparency, accountability, equity and corporate responsibil- we operate and aim to create social value through three princi- ity as central to its business. Roche provides training to employ- pal pillars: childhood, education and empowerment of the local ees on ethics and compliance. community.

Roche suppliers are also subject to the Group’s Code of Con- In 2014 and 2015 Roche conducted eight community initiatives, duct and 853 suppliers participated in e-learnings around these reaching 3,787 people in 2014 and 10,328 people in 2015. A few topics in 2014 and 2015. Since 2014 Roche Brazil has conduct- of the local community initiatives implemented in Brazil during ed 12 supplier sustainability audits to ensure they follow cor- this time included: porate guidelines. • Throughout 2014 and 2015, Roche sent five volunteer em- Pharmacovigilance, a larger corporate initiative, helps manage ployees to visit some 20 low-income, isolated cities to provide patient safety. Through this programme, safety information about healthcare, entertainment (sports, paintings, movies) and Roche pharmaceutical products is collected throughout their environmental sustainability work (installation of tanks and lifecycle to ensure products are safe. The detailed product moni- water filters), reaching a total of 7,800 people. During this toring aims to identify, assess and prevent adverse effects or any time, Roche screened over 600 people for hypertension and other type of problem related to the use of a drug. diabetes, and provided ophthalmological evaluations for 600 people. Additionally, 94 children received pediatric check- ups and over 2,000 anthelmintic treatments were distributed as part of the programme. A separate campaign around skin cancer awareness and treatment was also promoted; it reached 224 people and resulted in 56 needed surgeries.

• Taking an active role in their local community, Roche employees helped revitalise a space at the Benefactor Society of Jaguaré where 900 children and teenagers attend environmental management classes. They also organised a series of recreational activities for 35 children in another school of the region.

• Roche expanded the “Good Neighbour” programme in In 2014 and 2015 2014 to include new partners and initiatives. The expansion strengthened projects to support the local community of Jag- Roche conducted eight uaré, where Roche’s headquarters are located, making them more sustainable with the help of other partners, and extend- community initiatives, ing their reach to a greater number of people. reaching more than 14,000 people.

70 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 71 Watch video here Central America and the Caribbean

“I needed a hand, and they lent two to hold me.”

Environment Iris Arias Breast cancer survivor Roche Brazil works to reduce the environmental impact of its The industrial plant of Roche Brazil, located in Rio de Janeiro, activities through programmes that focus on sustainability, spe- has a built-in water treatment system that allows for the reuse of cifically water usage. Roche was able to reduce water pressure water for the facility’s cooling and gardening. The recycling rate When I was 40 I got the visit that nobody wants to receive: breast The benefits of a clinical trial are countless, especially the quality through its facilities from six litres of water per minute to one corresponds to 10%-20% of the total consumption, which trans- cancer. My doctor called me for a check-up and found that some- of life that we, the patients, gain. And I found so much sensitiv- litre of water per minute, making progress on its goal of decreas- lates into a savings of 10,000-20,000 m3 of potable water annually. thing was not right. Then they ran biopsies and tests, and I was ity along the process. The team managing the study for me was ing monthly consumption of water by 50-70%. Additionally, to diagnosed with cancer. Ten years ago, when I was diagnosed, can- a cushion, softening my falls at every step. And the doctor-pa- conserve water and protect the environment, Roche does not In 2014 the publisher Gestão RH distinguished Roche Brazil as one cer was a synonym of death. I felt like the curtain of my life was tient relationship was excellent, because for me it was important, use products that contain chemicals or detergent when washing of the 10 Best Companies in Corporate Citizenship, with a spe- starting to come down, and that in a very short time I would not but for the doctors too, as we were all part of a protocol. It was building façades. cial distinction in Environmental Responsibility. In 2014 and 2015 be able to be with my children anymore. important that I had four or five years’ survival, when life ex- the Syndicate of Pharmaceutical Products in the State of São Paulo pectancy was no more than two years. I was the example that it (Sindusfarma) also distinguished Roche with an Honourable Men- When I got my last cycle of chemotherapy, the doctor told me was possible, that the treatment was giving the results everyone tion of Excellence in Safety, Health and Environmental Protection. about the Hera protocol. The first thing my husband asked was wanted to see. whether there was any risk involved. And I said, “I have already been in a very frightening place, what else can happen? What will In 2003 I started with the clinical protocol, and in 2014 I was clos- come has to be better.” Going through the treatment was exhaust- ing my experience with wonderful results. To my husband I now ing, but I knew I was rebuilding my life, my future. say “We did it, and it was worth it.”

72 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 73 Roche Central America and Heredia 1965 the Caribbean at a Glance Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 343 58.9% 52.2% 6.7% 2014 2014 2014 2014 343 57.7% 45.7% 9.5% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 48 5 8,757 26.7 2014 2014 2014 2014 41 12 10,594 23.1 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 59 61 Investment in R&D (mCHF)(20) 5 6

Number of Active Sites 81 83 Number of Employees in R&D 35 34

(20) Million Swiss francs Number of Patients 315 333 Healthcare in Central America Roche in Central America and in Clinical Trials and the Caribbean the Caribbean

The Roche Central America and the Caribbean (CAC) region is Roche has been present in Central America and the Caribbean Environment(21) 2014 2015 comprised of 12 independent nations with a number of health- since 1965 and serves the following countries: care initiatives including the Council of Ministers of Health of Energy Consumption (GJ) 34,179 40,447 Central America, which focuses on improving healthcare condi- • Central America: Guatemala, Honduras, El Salvador, Nicara- tions within the member countries. Currently only 36% of the gua, Costa Rica and Panama. CAC population has healthcare coverage, and as such, there is GHG Emissions (tons) 2,716 2,711 ongoing debate around access to healthcare, pricing of coverage • The Caribbean: Dominican Republic, Cuba, Trinidad and To- and the health rights of the people in the region. The majority of bago, Bahamas, Bermuda and Jamaica. Other small islands are Water Consumption (cubic meters) n/a 3,190 these conversations centre on chronic disease, disease prevention covered through a network of distributors. and the lack of resources in the public healthcare system. Six products dominated regional sales in 2014 and 2015, with General Waste Produced (tons) n/a n/a In this region non-communicable diseases such as cancer are sur- a strong focus on oncology to mirror the principal needs of the passing infectious diseases as the leading health threat in middle- region. Research and trials during this time led to regulatory ap- Recycling (tons) 11 8 and low-income countries. CAC countries are under pressure proval of two new products that treat cervical cancer and lym- to respond to the increase in mortality rates from these diseases phoma. Currently 11 Roche products are covered by the region’s with expanded resources and services, increased training and im- public health system. Paper Consumption (tons) 3 4 proved infrastructure. Currently Panama and Costa Rica lead the region in terms of regulatory strength and organisation. Investment in SHE (CHF)(22) 37,000 1,739,000 (Safety, Security, Health and Environment)

(21) Environmental data is for Costa Rica only (22) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

74 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 75 In 2014 and 2015, we conducted 120 studies across 164 research centres with 648 patients.

Sustainability Initiatives Access to Healthcare

At Roche we tailor our approach to the individualised healthcare needs of every country we support with the goal that every person who needs our products will be able to access and benefit from them. In Central America and the Caribbean, we create and promote initiatives that support the Group’s five pillars: Deliv- ering Innovation, Increasing Disease Awareness, Strengthening Healthcare Infrastructure, Improving Affordability and Support- ing Local Patient Organisations.

Delivering Innovation

Roche is committed to creating and developing medications and diagnostics that meet people’s health needs. To deliver on this commitment, we conducted 120 studies across 164 research centres that involved 648 patients in 2014 and 2015. The studies focused primarily on oncology and the metabolic and immune systems.

Roche also worked with the First Latin American Centre on ALEX, a phase III clinical trial comparing the success and safety of a new compound to an existing medicine for patients with non-small cell lung cancer and tumours positive to the marker ALK plus. Research began in December 2014 in Costa Rica, and involved Guatemala and other Latin American countries such as Mexico, Peru and Chile.

In 2014 and 2015 Roche continued work with the “Compre- hensive Solution” initiative, an agreement between El Salvador, Clinical studies in Central Dominican Republic, Jamaica, Barbados and Cuba to improve cancer detection, diagnosis and treatment. As a result of this col- America and the Caribbean laboration, El Salvador saw a 46% increase in lymphoma patients’ access to medication. Breast cancer patients were also better able have focused primarily on to access the treatment they needed (91% in El Salvador, 15% in the Dominican Republic and 30% in Cuba). Moreover, 60 patients oncology and the metabolic in Jamaica and 56 in Barbados benefitted from the agreement. and immune systems.

76 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 77 Roche has supported the “Run for Me” Increasing Disease Awareness Strengthening Healthcare Infrastructure 10 kilometre run and Roche believes that awareness and support for health are just as Creating greater and equal access to healthcare often requires im- important as access to the treatment and care patients need. provements in basic infrastructure, medical education and train- walk event since 2009. ing. As such, Roche developed multiple programmes that address In partnership with the non-governmental organisation Fun- local problems and work to increase healthcare access through daCáncer and the Pink Tour Association, Roche has supported stronger infrastructure. the “Run for Me” 10-kilometre run and walk event since 2009 to increase awareness of the importance of diagnosing breast cancer In support of Panama’s Early Reference Programme, Roche helps early. Through our work with this programme, we have increased patients access treatment for colorectal cancer, non-Hodgkin’s participation to 11,000 people and have helped raise more than lymphoma and stage two (or advanced) breast cancer. The pro- 112 million CRC.(23) gramme specifically targets patients in areas where incident rates for these diseases are high and the healthcare infrastructure can- Roche also provided support to a lymphoma awareness campaign not support the right level of care. To develop a better system, in 2015 conducted in partnership with Panama’s National Oncol- Roche helped identify and implement new processes that could ogy Institute and Guatemala’s National Haematology-Oncology sustainably support patients. association to promote awareness around treatment options. Roche has also established a comprehensive healthcare agreement with three countries, including El Salvador, Cuba and Do- minican Republic, to help healthcare facilities access diagnostic (23) Costa Rican colons equipment and obtain a long-term supply of Roche’s reagents and medicines. In this agreement, Roche also helps improve on-site automation processes and train clinical pathology personnel.

78 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 79 Tackling specific issues around affordability, Roche works with Supporting Local Patient Organisations multiple initiatives to Recognising the great work done by local organisations to support patient care, Roche partners with a number of programmes, promote healthcare providing 130,000 USD(24) in contributions. access for treatments In 2014 and 2015 we supported the following organisations across five CAC countries, contributing to capacity building in different that are the most areas such as disease education and patient advocacy. needed in each market. Costa Rica El Salvador Improving Affordability • Anasovi • APREDESAL • Pink Tour Association At Roche we carefully adapt our approach to the needs of each Roche partnered with the Cuban Health System to produce the • Amuro Honduras market to ensure that the right products are accessible to the pa- Comprehensive Settlement Agreement, a collaboration with the • Choose Life • Faith and Hope tients who need them. Tackling specific issues around affordabili- public health sector to adjust costs in order to provide patients • Resurge • Ashoper ty in these markets, Roche works with multiple initiatives to pro- with more reliable diagnoses, reduce response times and deliv- • FundaCáncer mote healthcare access for treatments that are the most needed in er needed treatments. The programme covers treatments for co- Guatemala each market. lon and HER2 breast cancer, and facilitates future diagnosis of Panama • Hope Heroes HER2-positive breast cancer and non-Hodgkin’s lymphoma for • Funarp • Rebuilding Lives In 2014 Roche developed joint Pharma-Diagnostics packag- the entire Cuban population. • Anpirfc es that allow institutions to upgrade diagnostics capabilities, • APEHE expand access to oncology drugs and reduce costs. The pro- • ASONAPAQ gramme helps set pricing models for a longer period of time and • FundaCáncer ensures that patients are able to access the medicines they need for proper treatment.

(24) United States dollars

80 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 81 Employees Governance

Roche Central America and the Caribbean employs 343 people Following the Group’s guidelines on Corporate Governance, covering 23 nationalities. Employees are offered a range of ben- Roche in Central America and the Caribbean ensures that all efits and several employee programmes promote well rounded, employees and business managers perform their duties in accor- healthy lifestyles. dance with the Group’s ethical principles.

In 2015 Roche launched a flexible benefits programme, Roche Since 2013 Roche has implemented the new working model “MyWay,” which allows employees to customise the benefits they “Symphony,” which redefines accountabilities between Medical prefer. The programme integrates a flexible working from home and Commercial functions in line with expectations and require- office policy, recognition for work done on weekends and the ments in the regulatory environment. Roche CAC has also de- opportunity for employees to take a language course out of the veloped an electronic tool to manage Symphony and RACI (Role country, among other incentives. and Responsibility Matrix) processes in the region’s countries to maintain efficacy and ensure compliance requirements are met. The project required integration across sales, medical, commercial, legal, compliance and finance teams.

In compliance with Roche policy, business units follow a stan- In 2015 Roche launched dardised process to detect counterfeiting and escalate issues. In 2014 and 2015 our Pharmacovigilance system successfully a flexible benefits identified and prevented two counterfeiting cases in Honduras and Guatemala. programme, Roche “MyWay,” which allows employees to customise the benefits they prefer.

82 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 83 Chile

Communities

Roche is committed to the communities it serves and invests in “We can make a difference three primary areas: childhood, education and local community development. In Central America and the Caribbean, communi- if we all push towards the ty initiatives during 2014 and 2015 primarily focused on children and education. I define myself as a very passionate person, very focused on my same goal.” goals and trying to make a difference every day. One way I feel I In 2014 Roche continued the “Books for All” programme, where give my two cents is with my daily work, which consists of prepar- Camila Mugli a group of Roche employees donated classroom materials to un- ing all the scientific and technical documentation for submission Regulatory Affairs Specialist at Roche Chile derprivileged children in two primary schools in the communi- to the regulatory authority, so that medicines can be distributed ty of Heredia, Costa Rica, where the company is headquartered. in accordance with local laws, and arrive safely and effectively to The activity benefitted more than 300 students from first to sixth each patient. grade during 2014 and 2015. I also always try to go beyond, looking into the future and seeking In 2014, we also organised together with the Social Action Com- to change it. For me, working here means being part of a committee a volunteer activity where we rebuilt trails in one of the Environment pany that gives me the opportunity to truly make a difference. most important hills of Santiago. The activity was very positive Everyone here, regardless of the area they are in, shares this same in that we were able to raise awareness and contribute to envi- At Roche we strive to reduce the environmental impact of our goal, to improve people’s lives. ronmental protection. And one of the most significant things facilities through sustainable buildings and strong recycling was that there was a lot of teamwork. There were volunteers from programmes. In 2015 Roche Central America and the Caribbe- Recently, we organised to collect gifts for children with respiratory all areas of the company, from general management to support, an invested 5.5 million USD in new administrative offices and a diseases. This was a very touching and fulfilling experience, to bring which made the activity very enriching. distribution centre that together support all 23 countries in the happiness to hospitalized children. Through this type of actions, CAC affiliate. The distribution centre and offices were designed to you realize how, with a small act, we can make a big difference. You know that you can make a difference when you realize ev- lower our environmental footprint and earned the Leadership in eryone is going towards the same goal. In our case, to improve Energy & Environmental Design (LEED®) Certification from the people’s lives. US Green Building Council.

84 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 85 Roche Chile at a Glance Santiago 1972 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 229 49.3% 50% 16.3% 2014 2014 2014 2014 259 53.3% 50% 10.3% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 47 4 1,826 8 2014 2014 2014 2014 52 11 4,858 18.8 2015 2015 2015 2015 Healthcare in Chile

Chile has one of the best Human Development ratings in Latin up to 70% lower than before the programme began. Due to the Clinical Trials 2014 2015 Research & Development 2014 2015 America, which is measured by the ability of citizens within a success of this model, other communities in the country have an- country to be educated, healthy, have a reasonable standard of alysed their own systems and processes to reduce drug costs for Number of Clinical Studies 26 29 Investment in R&D (mCHF)(25) 2 2 living, feel safe and keep that capacity in the long term. About their residents. 95% of Chile’s 17.7 million inhabitants have healthcare coverage. These efforts have increased the number of Chileans with access Number of Active Sites 86 80 Number of Employees in R&D 22 24 In 2003, the Chilean healthcare system began reforms, culmi- to healthcare services and products for cancer, chronic diseases nating with the 2005 Law No. 19,966 that guarantees universal and other complex conditions. The next priority in Chile will be (25) Million Swiss francs Number of Patients 297 250 access through the “Universal Access Plan with Explicit Guaran- to modernize its cancer centres, in order to gather better evidence in Clinical Trials tees” (AUGE). This legal framework not only improved access to of new cases and improve incidence data. healthcare services, but also financially guaranteed support for a number of diseases, including cancer. These developments have Environment 2014 2015 helped Chile’s National Cancer Programme take major strides in Roche in Chile the fight against the disease. Recently, prevention and radiother- Energy Consumption (GJ) 22,567 27,442 apy programmes, focusing on breast and cervical cancer, have Roche Chile has been present in the country since 1971, where been developed to provide protocols that increase the safety of it operates through its Pharmaceutical, Diagnostics and Diabetes patients and staff members. Care divisions. In the oncology and biotechnology fields, Roche GHG Emissions (tons) 1,491 1,828 ranks in the number one position in Chile with six anticancer The fight against cancer continues to be one of the greatest chal- drugs that increase survival rates for patients. Roche Chile is a Water Consumption (cubic meters) n/a 712 lenges faced in Chile’s healthcare landscape. In Chile, 11,630 men front runner in personalised medicines and was one of the first and 16,794 women die annually from cancer, which translates to companies to bring targeted treatments to patients. a country rate of 28,424 cases every year. This makes cancer the General Waste Produced (tons) n/a n/a second largest cause of death in Chile, after cardiovascular dis- In 2014, Roche Chile launched its first Corporate Social Respon- eases. The World Health Organisation has suggested that within sibility (CSR) programme, focused on contributions to society Recycling (tons) 37 31 the next five years, cancer will surpass cardiovascular disease to and environment with excellence in all Roche activities. This pro- become the leading cause of death in the country. gramme supports proactive interactions with Chilean communities to ensure long-term value creation and environmental inno- Paper Consumption (tons) 2 2 Access to medicines and high cost therapies is one of the coun- vation. The programme’s main areas of focus are: promotion of try’s biggest social challenges, especially as cancer rates are on the scientific education and healthcare, environmental sustainabili- Investment in SHE (CHF)(26) 7,000 n/a rise. To address this issue, the government enacted the Ricarte ty and humanitarian projects. In 2015, Roche Chile was ranked (Safety, Security, Health and Environment) Soto Law to fund high cost medicines and in October 2015, the seventh in the PROhumana Corporate Sustainability Ranking, a (26) Investment ﬁgures in Swiss francs and also include the Diagnostics Division first municipal pharmacy was opened in Recoleta, which delivers non-profit working in the areas of sustainability, green growth, affordable drugs to residents of the community, often at prices corporate social responsibility and responsible citizenship.

86 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 87 Roche Chile has invested four million Swiss francs in research and development throughout 2014 and 2015.

Sustainability Initiatives Access to Healthcare

Roche Chile is focused on ensuring all citizens have access to healthcare services and products that are vital to treatment. As such, Roche believes that equitable and sustainable solutions to the barriers in healthcare can only be achieved through the cooperation of public authorities, non-governmental stakeholders, local communities, and the healthcare industry.

Roche Chile strives to improve healthcare within the country following the Group’s five pillars: Delivering Innovation, Increasing Disease Awareness, Strengthening Healthcare Infrastructure, Im- proving Affordability, and Supporting Local Patient Organisations.

Delivering Innovation

Recognizing the importance of advancing medicine and technologies, Roche Chile has invested four million Swiss francs in research and development throughout 2014 and 2015. In 2014, Roche conducted 26 clinical studies focused on breast and lung cancer, across 86 sites involving 297 patients and increased efforts in 2015, supporting 29 clinical studies with a total investment of over 5.5 million USD.(27)

Next to the development of breakthrough medicines, Roche Roche Chile works in partnership Chile works in partnership with different stakeholders to support patients through innovation. In alliance with the National Cancer with different stakeholders to support Institute, Roche developed a pilot programme involving a software for breast pathology units at healthcare institutions to im- patients through innovation. prove the registry of cases and the admission process for patients with breast cancer.

(27) United States dollars

88 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 89 Roche Chile prioritizes support for programmes Increasing Disease Awareness aimed to educate the Awareness and effective support are as important to a patient’s public on early diagnosis well-being as proper diagnosis and treatment. Roche Chile is committed to a number of initiatives that seek to increase aware- and appropriate ness about health and disease to improve the effectiveness of medical treatments for patients. Roche Chile prioritizes support treatment for patients. for programmes aimed to educate the public on early diagnosis and appropriate treatment for patients.

Roche Chile developed several public campaigns during 2014 and 2015 with a focus on cancer awareness and detection, specifically for lymphoma, breast, lung, ovarian, cervical, and colorectal cancers, melanoma, and arthritis, among other diseases. A few sample initiatives conducted during this time included: • “Move on Time” initiative: Supporting 2014’s World Arthri- tis Day, Roche worked with the I Move Foundation to drive • “Hands-on: Touch and Take Care of Them” campaign: Since awareness around the benefits of early diagnosis for arthritis. 2012, Roche has led this campaign annually during breast Roche Chile also set up an informational booth and tree props cancer awareness month, however in 2014, Roche expanded at local events, where patients could write the activities they activities beyond October through the end of the year where continue to do, despite the impact of the disease. Publications we helped to launch a book, “Mammography and BI RADS: reached an estimated 470.000 people and about 50 patients Approaches on Primary Care.” During the three month cam- participated in the local event. paign, Roche’s activities focused on educating both primary health services midwives and specialists through 15 lectures • “With You, I Move” campaign: Roche again partnered with to increase awareness about free services for breast cancer di- the I Move Foundation in 2015 to inform the community agnosis and treatment. about what means to live with rheumatoid arthritis. Together, they set up information points in areas with high pedestrian • “Pink October” campaign: In collaboration with the NGO traffic, such as shopping centres, and invited the community to I Woman and the National Cancer Institute, Roche helped wear a suit that simulates the stiffness experienced by rheuma- to develop a video promoting breast self-examinations, dis- toid arthritis patients. The campaign helped people to better seminated information about cancer, and sponsored the walk understand the disease, its effects and why an early diagnosis “Let’s Run Together against Breast Cancer” in 2014. The video is important. reached over 6,200 views and more than 6,000 people participated in the awareness walk. Roche continued support of the • “Hepatitis C Detection” campaign: As hepatitis C is the lead- programme in 2015 with the development of a new video that ing cause of liver transplants in Chile and the world, Roche stressed the importance of preventive periodic mammograms worked with the Davila Clinic to disseminate information and self-exams, helped to amplify awareness messaging and around disease prevention and for the fifth year in a row, sponsored the annual walk “Run for Life” for 800 attendees. Roche provided free blood tests.

90 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 91 Supporting Local Patient Organisations

At Roche, we recognize the great work being done in healthcare through patient organisations and our priority is to support them in breaking down barriers to access care. In 2014 and 2015, Roche Chile contributed over 13.1 million CLP in this area and supported 15 organisations including: Cancer Life, Flying Corporation, A New Rebirth, New Life Group, I Move Foundation, Vasculitis Chile, Gist Chile, Anacroj, Hope Group, Cystic Fibrosis Corpora- tion, Transplant Corporation, I Woman Institute, Cancer Coach- ing Foundation Chile, and the Lymphoma Foundation Chile.

In 2014, Roche held the first annual national educational meeting for 100 rheumatoid arthritis patients to discuss early diagnosis, treatment adherence and general education about the disease. The event helped to develop a support system for patients and drove awareness around the disease.

In 2014 and 2015, Strengthening Healthcare Infrastructure Improving Affordability Roche Chile contributed Roche Chile has established many programmes that address bar- Affordable healthcare constitutes a priority in Chile and as such, over 13.1 million CLP to riers to healthcare access including activities that aim to improve Roche Chile has created several initiatives that help break down basic infrastructure, medical education and training. the barriers that prevent patients from accessing the treatments support 15 patient they need. These include: During 2014, Roche Chile developed four initiatives that con- organisations. tributed to stronger healthcare infrastructure in the country. In • The “Compassionate Use” programme, which helps patients support of health specialists, Roche offered two scholarships to to access therapeutic options that are not currently available oncology and haematology specialty grades at the University of within the country. The products included in this programme Chile and donated advanced equipment to Sótero Río Hospital. target HER2 breast cancer, chronic lymphocytic leukaemia, Roche also supported the Cancer Foundation in Valdivia with melanoma, non-small cell lung cancer, and cases of locally the development of a software for prescribing chemotherapy elec- advanced basal cell carcinoma which are not candidates for tronically to ensure accurate preparations and the traceability of surgery. oncological drugs. • The “Access Solutions” programme, which provides support In 2015, Roche Chile supported five initiatives, invested over 18 to patients during treatment for rheumatoid arthritis, offering million CLP(28) in healthcare infrastructure, and hosted med- orientation on general aspects of treatment and financial sup- ical trainings for 563 healthcare practitioners. Donations made port when needed. to local hospitals, which included breast cancer pathology software, biological treatment infusion pumps, and facility furniture, • A mobile mammography station, installed in partnership with helped local institutions to expand care in their communities. San Miguel City Hall and Arturo López Pérez Foundation, and that provided free mammograms to 565 women who did not have the resources to fund the test. (28) Chilean pesos

92 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 93 Employees Governance

Roche Chile currently employs 259 people; 53% women and 47% Following the Group’s guidelines on Corporate Governance, men. All employees receive regular performance and professional Roche Chile ensures that all employees and business managers development evaluations as well as benefits that help to promote perform their duties based on the company’s ethical principles. a healthy work-life balance. In 2014, Roche Chile was recognized Roche Chile conducted a total of 2,440 trainings throughout 2014 in the 18th position in the Great Place to Work® ranking and and 2015 on a range of topics including adverse event reporting the lowest salary offered at Roche Chile is 220% higher than the for Roche products, the Roche Code of Conduct, records man- country’s minimum wage. agement and electronic communications. Roche Chile also completed eight supplier audits and hosted an annual “Supplier Day” Employees at Roche Chile work 38 hours per week instead of the to ensure suppliers are aligned with corporate guidelines. typical 45 hours and the company offers benefits such as the ability to work from home, early leave on Fridays, a holiday week between Christmas and New Year, bonus opportunities and a Communities recognition programme, among others. Roche’s “Live Well. Find your Balance” programme helps to foster a culture of health and Roche is deeply committed to the communities where it operates well-being among Roche Chile employees. As part of the pro- and allocates its community investments with the aim of creating gramme, Roche conducted an employee health fair and spon- social value in three main areas: childhood, education, and the sored a healthy breakfast campaign. local community.

Roche Chile also offers a variety of trainings to help employees Roche Chile conducted two initiatives in 2014 and 2015 around develop professionally including training for managers on dif- Christmas to help children in need, reaching over 100 people. ficult conversations, human resources workshops, and leader- In 2014, Roche employees sponsored 70 low-income families ship training. during the holidays in order to help children get back into the “spirit of Christmas.” The following year, employees volunteered In 2015, Roche Chile focused on redesigning their diversity and at a Christmas party for low income children with respiratory inclusion programme with input and help from employees. Roche diseases and donated one gift per child, benefitting 49 children hosted a forum where participants were asked to write down on a and families. white board their impressions and commitment towards diversity and inclusion which were later shared widely in the cafeteria to To encourage employee volunteering, Roche also developed develop Roche’s commitment to a diverse and inclusive culture. “Changing Chile in 20 hours,” a programme that allows employees to donate 20 hours of their time towards community organisations and programmes. This helps employees to get involved in their local community and feel that they can truly make an impactful change. Since initiating this programme in 2015, 70 employees have contributed to two activities benefitting a total of 119 people.

94 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 95 Watch video here Colombia

“With the proper disposal I manage the Colombian National Association of Retail Druggists of medicines, we can (Asocoldro). We are a trade organisation dedicated to addressing the needs of pharmacists in Colombia. We currently count with protect the environment eight thousand members across the country. Environment and prevent counterfeiting An important issue we have been working on has to do with the Roche has worked to reduce the indirect environmental impact To promote environmental education, Roche Chile employees disposal of leftover medicines. When unused or expired drugs at the same time.” of its activities in Chile by developing energy-saving policies, op- participated in the “Handmade Sustainability” initiative, restor- are dumped into toilets and sinks, they pollute the environment. timizing its use of renewable and non-renewable resources, and ing a 2.5 kilometres path on the San Cristobal Hill in Santiago And their packaging, blisters and boxes, when dropped into the Alba Rocío Rueda Gómez taking safety, health and environmental protection actions. that was in poor condition. The activity helped teach employees garbage, can also contribute to counterfeiting and drug adulter- National Executive Director of Asocoldro to care for the urban environment and reinforced company initia- ation. This constitutes an issue of both environmental protection We are proud that Roche Chile’s office building has received the tives around environmental sustainability. and public health, which the national government also seeks to Leadership in Energy & Environmental Design (LEED®) Gold address through norms and policies. Certification and to lessen Roche’s environmental impact, we support companywide recycling campaigns, as well as volunteer That is why we are very pleased with the programme that the or- Today, druggists across the country are committed to a proper work designated towards sustainability. ganisation Blue Point and Roche are advancing, which looks to disposal of medicines. What is more, our members are convey- properly discard leftover medicines. With the trainings provided, ing the same commitment to patients, encouraging them to bring we have been able to raise awareness about this issue among our unused and expired medicines to the pharmacy and leave them druggists. The results have been remarkable. We already see that in the consigned containers, instead of throwing them in the gar- all our members, in all the events we organise, raise their hands bage. In this way, awareness has spread to the general population. and ask for the containers to collect expired or unused drugs. This is certainly a timely and commendable initiative to promote both environmental and public health.

96 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 97 Roche Colombia at a Glance Bogota 1957 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 352 60.8% 44.2% 10% 2014 2014 2014 2014 395 61.5% 44.8% 6.9% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 42 13 8,498 24.1 2014 2014 2014 2014 75 17 11,012 27.9 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015 Healthcare in Colombia Roche in Colombia Number of Clinical Studies 23 22 Investment in R&D (mCHF)(29) 3 4 Cancer is the third most frequent cause of death in Colombia with Present in Colombia since 1940 and with an official location -es incident rates continuing to rise. The government estimates that by tablished there in 1957, Roche has become a leader in person- Number of Active Sites 67 60 Number of Employees in R&D 24 54 2020 there will be 130,969 new cancer cases, causing expenditures alised medicine, combining diagnostic and pharma solutions. to increase. In recent years, Colombia has seen about 5,663 new Roche is recognised as central to the value chain of the Colombi- (29) Million Swiss francs Number of Patients 128 127 cancer cases per year, with an annual mortality rate of approxi- an healthcare system and covers important unmet needs in med- in Clinical Trials mately 3,200 cases. In response, Colombia has prioritised oncology ical fields for the country. in its healthcare conversations about providing better drug prices, reducing access barriers, creating financial stability within health- Roche Colombia supports more than 22,000 patients with its Environment 2014 2015 care infrastructure and managing biotechnological decrees. products, many of them served through Roche’s personalised medicine, which allows for greater alignment between the treat- Energy Consumption (GJ) 23,694 18,807 Colombia invests 7.6% of its total gross domestic product annually ment and the patients’ specific needs through the use of diagnos- in healthcare, covering 96% of its 48 million inhabitants. The na- tic tools. Through Roche’s active participation in the formulation tional healthcare system offers health insurance through two main of public policies, Roche Colombia remains a leader in innova- GHG Emissions (tons) 1,442 1,330 plans: the Contribution Plan, which covers a wide assortment of tion, contributing to a variety of medical fields – chiefly oncology. technologies and diagnostic tests, and the Subsidised Plan, which Water Consumption (cubic meters) n/a n/a primarily ensures coverage of the low-income population. Roche Colombia is also a critical bridge between public and private healthcare organisations to support a high level of care At present, oncology services are concentrated in the country’s and attention for patients, including providing healthcare access. General Waste Produced (tons) 6 15 major urban centres and as a result, the 61% of the population Roche supports these organisations in developing models for the located in remote and rural areas have little access to these ser- comprehensive management of diseases, such as cancer, and aims Recycling (tons) 125 95 vices. Therefore, many rural patients are diagnosed in advanced to support the best clinical and administrative outcomes. stages of their disease, making access to treatment and its overall effectiveness challenging. Paper Consumption (tons) 9 11 The Colombian government does issue guidelines for the com- Investment in SHE (CHF)(30) 28,000 22,000 prehensive management of cancer; however, progress is slow (Safety, Security, Health and Environment) within the system and there are limited resources to promote ear- (30) Investment ﬁgures in Swiss francs and also include the Diagnostics Division ly diagnosis and appropriate treatment.

98 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 99 Roche Colombia invested Sustainability Initiatives 8,360 million COP in clinical Access to Healthcare trials during 2014 and 2015. At Roche we believe that anyone who needs the treatment of our products should be able to access them. In order to help patients overcome local barriers to healthcare, we conduct efforts based on the Group’s five pillars to provide equitable and sustainable solutions: Delivering Innovation, Increasing Disease Awareness, Strengthening Healthcare Infrastructure, Improving Affordabili- ty and Supporting Local Patient Organisations.

Delivering Innovation

In an effort to advance medicine and medical technologies, Roche Colombia invested 8,360 million COP(31) in clinical trials during 2014 and 2015. In 2014 Roche participated in 23 clinical studies across 67 sites, involving 128 patients in areas such as oncology, haematology and arthritis. In 2015 Roche continued to perform studies in these areas, participating in 22 clinical studies across 60 sites and improving well-being for 127 patients. During the two year period, Roche also invested a total of seven million Swiss francs in research and development. A few programmes that have driven innovation in healthcare in Colombia include:

• “Forum on Scientific Innovation”:The forum is an annual initiative led by Roche since 2012 and serves as a platform for those in the healthcare industry to discuss personalised healthcare, how to increase a patient’s well-being and driving innovation within the field. The close to 200 forum participants include representatives of the public and private sectors, academics, physicians, patients and representatives from the pharmaceutical industry. In 2015 the forum focused on advances in women’s oncology and discussed the latest information on breast, cervical and ovarian cancer. The Forum also featured discussions on the role of scientific innovation for disease control and prioritising women’s cancer in the public agenda.

• Traceability Programme: Designed as a fast verification system for suspicious products, the traceability programme is an innovative initiative that ensures patients receive reliable medications needed for proper treatment with a guarantee that they were imported and distributed directly by Roche.

(31) Colombian pesos

100 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 101 Roche Colombia participates in several activities to drive awareness and education Increasing Disease Awareness around disease.

Recognising that awareness of health issues helps to drive support for new innovations, early diagnoses and increased preventative measures, Roche Colombia participates in several activities to drive awareness and education around disease. In 2014 and 2015 Roche drove awareness initiatives around the following public campaigns: World Cancer Day, Colon Cancer Awareness Month, World Kidney Day, Word Ovarian Cancer Day and Skin • “Pink October”: In 2014, for the third consecutive year, Cancer Awareness Day. These campaigns reached more than Roche lit its office in pink as a symbol to recognise breast can- 1,200 people in both 2014 and 2015 and assisted 9,446 (2014) cer patients and highlight the company’s commitment to fight and 9,458 (2015) patients in Colombia during those years. against the disease. In 2015 Roche developed the campaign, “To See Without Touching is Neglecting,” during Pink Octo- A few of the initiatives driving disease awareness included: ber to raise awareness about breast cancer.

• “First Health Journalism Workshop”: The workshop, done • “Pink Consulting Rooms”: Focused on breast cancer, Roche in partnership with the University of the Andes (Uniandes), hoped to change the way people thought and treated breast focused on training journalists about health-related topics to cancer in the health system in order to reduce times between encourage high-quality media coverage of health issues in the suspected diagnosis, confirmed diagnosis and treatment. The country. The courses were dictated by journalism professors “Pink Consulting Rooms” enable practices with physicians in cooperation with medical and scientific experts in the ar- who have been trained in early detection of the pathology and eas of oncology, rheumatology and epidemiology. Topics in- standardised methods for medical care. Through referral, the cluded the importance of clinical studies in the development programme also helps to identify patients at risk or with a sus- of drugs, personalised medicines and awareness around breast pected cancer. In 2014 and 2015 there were approximately 100 and ovarian cancers. Pink Consulting Rooms supported by Roche Colombia.

102 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 103 To improve affordability, Roche Colombia supported the development of 47 comprehensive care models in breast and colon cancer with 13 health organisations.

Supporting Local Patient Organisations

Roche Colombia supported 25 patient organisations in 2014 and 15 in 2015 with a total financial contribution of more than four billion COP. A few of these organisations included: RAZA Foun- dation, Simmon Foundation, Fundayama, Vital Return, Nation- al Fundare, Cocoons and the Colombian Foundation for Cystic Fibrosis. A sample of programmes activated during this period included:

• Funding Sources and Social Project Formulation in EU- RO-Latin American Cooperation: In 2014 Roche hosted another training for three patient organisations about how to develop project concepts that diversify funding sources and produce cooperation on an international level.

• World Congress of Fundraising for Social Organisations: Roche Colombia provided a grant for three patient organisa- Strengthening Healthcare Infrastructure Improving Affordability tions to attend this event in Buenos Aries, Argentina in 2014. The event helped the patient organisations meet other funding Issues with basic infrastructure, medical education and profes- • Breast cancer awareness: Activities focused on developing Patient access to innovative treatments depends on a number of sources applicable to social organisations, integrating leaders sional training create significant barriers to healthcare access in new medical processes to improve early diagnosis and treat- factors, among which financing is key. When public health sys- to join networks at regional level fundraising, and ultimately Colombia. In 2014 Roche helped expand medical education and ment, in addition to Roche’s participation in public awareness tems cannot guarantee timely access to appropriate treatments, allowed the organisations to diversify their sources of funding training by conducting nearly 50 workshops on breast cancer campaigns around the disease. Roche Colombia hosted virtual private insurers are often the only alternative, playing a central and expand their portfolio of donors. with more than 4,000 participating physicians. In 2015 Roche and classroom workshops for 265 medical and paramedical role in providing coverage and protection from financial risks. also hosted trainings for over 8,500 health professionals in pa- staff throughout 10 municipalities and helped change current Roche Colombia works closely with the Colombian Federation • Latin American Forum on Biosimilars Grant: In 2015 Roche thologies, biomarkers, biotechnologies and adherence. Addition- infrastructure through the following: of Insurers (Fasecolda) to collect statistical information on can- Colombia provided a grant for three patient organisations al initiatives that Roche led to strengthen healthcare infrastruc- cer so that insurers can create coverage packages for oncological working with pathologies that have increased risk of using ture in Colombia included: » Better breast cancer management throughout different de- patients that consider the financial impact of the disease and pro- biosimilars in medical treatments. The leaders from these or- partments of the healthcare network. vide greater access to healthcare. ganisations attended this event in Brazil to strengthen the con- • Colorectal cancer awareness: Activities focused on efforts to cepts of biosimilars in immunogenicity as well as overcome improve the management of health outcomes in patients with » Development of a breast cancer healthcare model that inte- To improve affordability, Roche Colombia supported the devel- the challenges they face in pharmacovigilance. this disease, helping the system to optimise the use of resourc- grates disease management, from diagnosis to treatment, and opment of 47 comprehensive care models in breast and colon es in cost effective therapies. The awareness campaign also from level one to high complexity care. cancer with 13 health organisations. These models help improve • Capacity Building for Patient Organisation Leaders in trained 1,010 physicians nationwide and an additional 2,000 medical attention across the spectrum, starting with the diagno- Colombia: Roche Colombia formed a joint network of 19 staff in primary healthcare with established regional pro- » Collaboration with stakeholders to implement a new com- sis through to the patient’s treatment. Roche also supported 12 patient organisations to mitigate the impact of new patient grammes in colon cancer diagnosis in Cali, Bogota, Medellin, prehensive care model that allows for improvement of timely risk management models for breast cancer and eight for colorec- organisation laws and specifically address how they would Barranquilla and Bucaramanga. diagnoses and treatment of patients. tal cancer with public health secretaries. impact patient care.

104 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 105 Employees

Roche Colombia currently employs 395 employees; 61% are women and 39% are men. At Roche high performing individuals are essential to the company’s success and as such, we aim to re- tain highly driven employees who are committed and passionate about making a difference. In 2014 we invested over 40 million COP in skills development, hosted over 8,000 training hours and increased training opportunities to over 11,000 hours in 2015.

In 2014 Roche hosted the team building activity “Practice Labs” with 88 leaders focusing on career development. The programme, conducted in partnership with the Sergio Arboleda University, helped employees build competencies and skills that allow them Communities to grow professionally within the company. As an invested member of the local communities where Roche Roche also offers many employee benefits including flexible time, operates, Roche Colombia gives back through three main areas a companywide wellness programme and a recognition pro- to create social value: childhood, education and local community gramme for great work, among other opportunities that promote support. In 2014 Roche Colombia contributed 85 million COP to a healthy work-life balance. improve the community’s infrastructure. And during 2015 eighty Roche employees volunteered to support the Project Union In 2014 and 2015 Roche Colombia was listed among the top 20 Foundation in three community initiatives, helping 60 low-in- best workplaces in the country by the Great Place to Work® In- come families, 40 children with disabilities or chronic diseases, stitute. Also in 2015 MERCO, the most important indicator of and 30 elderly locals. corporate reputation in Colombia, placed Roche in top positions within its pharmaceutical sector and talent rankings. In 2015 Roche Colombia dissolved the “Roche Foundation” in the region and created a volunteer programme, “Friendly Hands,” in its place to create a larger local impact. The volunteer programme Governance encourages employees to contribute to society in various social causes that help create a better world. Following the Group’s guidelines on Corporate Governance, Roche applies the Group Code of Conduct, which sets the mandatory behaviour requirements for the entire company in order to ensure that staff members and business managers carry out their duties while holding the ethical principles of the company.

Roche trains all employees on ethics and compliance following these values. In 2015 Roche hosted 250 employees in nine differ- In 2015 Roche hosted ent eight-hour workshops on governance topics. At Roche we also follow guidelines to ensure the safety of our products and, as part 250 employees in nine of the Pharmaceutical Policy, we develop protection mechanisms to identify counterfeiting and drug smuggling. Roche Colombia different eight-hour is part of the Inter-Institutional Agreement for the Legality of Drugs in Colombia, together with the Association of Research workshops on and Development Pharmaceutical Laboratories (Afidro), the Pharmaceutical Industry Association of Colombia (ASINFAR), governance topics. the Colombian Association of Retail Druggists (Asocoldro), the National Federation of Trade (Fenalco) and Colombia’s Industrial Association (Andi). During 2014, under the agreement, Roche helped educate more than 3,000 druggists on the importance of avoiding the purchase and acquisition of fraudulent products of unknown origin.

At Roche we also work closely with our suppliers. Since 2014 Roche Colombia has performed 36 audits that help suppliers to improve their procedures and ensure that they are aligned with Roche corporate sustainability standards.

106 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 107 Ecuador

I have been a doctor for 20 years, specializing in genetics. I also “Sustainable development teach at the Medical School of the Central University. I decided to become a geneticist because I see science as the future of medi- in medicine requires all cine, and genetics is the most advanced branch of science. Environment actors to get involved.” To achieve sustainable development in medicine, it is important Roche Colombia strives to reduce the indirect environmental In 2015 Roche Colombia began a collaboration with the organ- that different actors – academia, industry, and the government – Fabricio González impact of its activities through energy-saving policies, pro- isation Fenalco Solidarity to measure the amount of carbon di- come together and get involved. The industry, for instance, can Geneticist grammes that optimise the use of renewable and non-renewable oxide and other greenhouse gases associated with Roche’s oper- contribute to progress in three ways. First, by supporting spe- resources and activities covering safety, health and environmen- ations in the country, with the goal to reduce the rate by 2020 cialized care in areas not yet covered by the country’s healthcare tal protection. During 2014 and 2015 Roche activated a recy- through new programmes. system. Second, through joint research projects to develop un- cling campaign, hosted discussions around environmental care derexplored fields. And finally, by promoting public policies that and provided opportunities for employees to volunteer in sus- As some environmental savings decreased from 2014 to 2015, favour the well-being of the population. tainability programmes. Roche is currently focused on improving programmes in areas that could be further improved and has established a plan aimed I have had the opportunity to see this collaboration first-hand and From this experience I have learned that the industry can prove at raising awareness among employees about the importance of in action in a support project for patients with cystic fibrosis. There to be a responsible and collaborative partner, and I think these resource savings. is not enough research and attention dedicated to genetic diseases. types of initiatives should continue, not only in the field of rare This many times translates into patients receiving a late diagno- diseases, but also in other areas that are important for the ad- sis, which affects their prognosis. Through the cystic fibrosis -pro vancement of healthcare in the country. gramme, physicians at the public university partnered with Roche, which in turn made a donation of equipment and supplies for the early detection of the disease. The initiative has been very positive in that it not only benefits the patients and their families, but it also informs medical students and supports academia in general.

108 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 109 Roche Ecuador at a Glance Quito 1980 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 157 52.2% 38.5% 42.4% 2014 2014 2014 2014 177 48.6% 43.5% 10.2% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 22 4 2,778 17.7 2014 2014 2014 2014 34 4 2,772 15.7 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 7 7 Investment in R&D (mCHF)(32) 2 2

Number of Active Sites 24 24 Number of Employees in R&D 13 12

(32) Million Swiss francs Number of Patients 88 85 in Clinical Trials Healthcare in Ecuador Roche in Ecuador

Environment 2014 2015 Ecuador’s constitution guarantees healthcare for all 16 million Headquartered in Quito, Roche has been present in Ecuador of its citizens. However, with a quarter of the population living since 1980. The current business climate in Ecuador for Roche Energy Consumption (GJ) 3,417 9,114 in poverty, access to healthcare is limited. The biggest healthcare has changed significantly in recent years as the price of oil, which issues faced by Ecuadorians today include insufficient access to is closely tied to the economy, fell more than 50%. This has had se- hospitals, inadequate diagnosis and poor treatment adherence. In rious implications for the government’s ability to provide health- GHG Emissions (tons) 168 565 2014 Roche Ecuador conducted a survey to understand the rea- care, and as a result, has affected and underscored the importance sons behind these issues and found that they were the result of a of Roche’s initiatives in the country. Water Consumption (cubic meters) n/a n/a lack of financial resources, understanding of hospital processes, disease education and psychological support. General Waste Produced (tons) n/a n/a Ecuador spends approximately 6% of its GDP on healthcare (3% public, 3% private). Ninety-five percent of the population is in- Recycling (tons) 2 2 sured by public healthcare and 5% by private insurers.

Paper Consumption (tons) 2 2

Investment in SHE (CHF)(33) 9,000 30,000 (Safety, Security, Health and Environment)

(33) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

110 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 111 In 2014-2015 Roche Ecuador focused on streamlining distribution and working mainly as a partner with public institutions.

Sustainability Initiatives Access to Healthcare

In 2014-2015 Roche Ecuador focused on streamlining distribution and working mainly as a partner with public institutions to develop health and social programmes and projects.

Delivering Innovation

Roche exists to create and develop medications and diagnostics to meet people’s health needs and substantially improve their quality of life. Part of this commitment involves supporting national initiatives in the countries where Roche operates to address community health needs.

In support of the government’s commitment to cancer diagnosis and treatment, Roche Ecuador produced a white paper with the Ecuadorian Society Against Cancer (Solca) on the state of cancer incidence and care in the country to help inform a broader analysis for Latin America.

112 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 113 Roche Ecuador engages with a variety of Increasing Disease Awareness organisations and Disease awareness and support are as important to a patient’s campaigns to increase well-being as proper diagnosis and treatment. Roche Ecuador engages with a variety of organisations and campaigns to in- awareness. crease awareness. A few of these initiatives conducted during the last two years deserve special mention:

• In 2014 four hundred healthcare professionals and 90 Roche employees in Quito and Guayaquil participated in the “Pink October” breast cancer awareness campaign. Volunteers helped distribute informational materials to nurses and physicians during a series of scientific meetings held across the country.

• Roche’s “Lymphoma: Recognise the Symptoms, Anticipate Strengthening Healthcare Infrastructure Cancer” campaign distributed green ribbons, symbolising lymphoma awareness, to doctors and patients from the Roche works to develop and cultivate programmes that improve Andrade Marín Hospital and Solca. Additionally, in an ef- healthcare infrastructure, education and medical training to re- fort to promote lymphoma’s early detection, the local team move barriers and increase access to basic healthcare in the re- shared information about the illness with the community gions where it operates. and disseminated related press materials to media outlets across the country. In 2014 Roche Ecuador launched “For You,” a pioneering and unique patient support programme specifically designed to ad- • In Ecuador cystic fibrosis has received so little attention that dress the unmet needs of cancer patients living in poverty, in accurate incidence rates do not even exist for the country. As remote areas, and/or with low levels of education. “For You” is a result, many cystic fibrosis patients are diagnosed in late an integrated programme that covers all aspects of the patient stages of the disease. This is particularly damaging, as early journey and ensures patients in need have access to hospitals, and correct diagnosis can significantly extend life expectancy receive the right diagnosis and are able to adhere to their treat- and quality of life. To promote access to early diagnosis, Roche ment plans. “For You” provides 360 degree support for patients, Ecuador partnered with public universities and physicians to including treatment logistics, guidance in hospital processes, di- add screening for cystic fibrosis to existing neonatal screening agnostics, education and emotional support. In its first year, the policies. This work started with a pilot screening programme programme launched in six of the 10 major public hospitals in for 101 new-borns, resulting in 10 cystic fibrosis diagnoses. Ecuador, reaching 10% of Ecuadorian cancer patients.

114 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 115 Communities

Recognising the importance of community involvement, Roche Ecuador invests to create social value in three principal areas: childhood, education and the local community. Throughout 2014 and 2015, Roche focused efforts specifically on humanitarian initiatives, science and education, reaching a total of 720 people.

• Community Week: Roche employees are very mindful of the communities in which they work, and the challenges those communities face. In 2015 eighty Roche employees in Quito and Guayaquil participated in Community Week, contributing to local service organisations that work with a variety of disadvantaged groups, including abandoned children, senior citizens, cancer patients and entrepreneurs with disabilities. In addition to volunteering at local non-governmental organisations, Roche Ecuador employees also or- Roche Ecuador was ganised awareness campaigns and fundraisers, including a bake-off, food fair and donate-your-teddy-bear campaign. recognised as one of the “Among the places that the volunteers visited was the non-profit organisation SOS Children’s Villages that works with abandoned best places to work in the children and those coming from broken homes. They held some fun shows with the kids and distributed snacks, bringing a smile country in 2014, receiving to their faces. The elderly residents of the Nursing Home Heart of Mary were treated to a musical show and participated in a a total of six “Best Place dance competition,” says Giovanna Vasquez, HR Business Part- ner Pharma. to Work” awards in the » Entrepreneurs with Disabilities: During Community last 10 years. Week, more than 30 Roche employees worked with Ecua- dor’s Technical Secretary for Disabilities to develop and de- ploy programmes that could be run by entrepreneurs with intellectual, visual, hearing and/or physical disabilities. “Of the 30 plus Roche employees, 14 were chosen to attend a specialised ‘train the trainer’ workshop and help facilitate training sessions in finance, sales and marketing, communications and general business knowledge,” explains Rocio Basantes, Roche Improving Affordability Employees Governance Ecuador Manager of Commercial & Organisational Develop- ment. “The two-day programme helped entrepreneurs visualise Roche adapts its healthcare strategy to meet the greatest needs in Roche believes that educated, engaged and motivated individuals Roche Ecuador follows the Group’s Code of Conduct and em- their start-ups and how to become more business oriented, get the markets where we operate. As such, affordable products and are essential to company success. Currently Roche employs 177 phasises transparency, accountability, equity and corporate re- better at financial planning, think of growth and profit and use diagnosis are in great demand within Ecuador, an area that Roche people in Ecuador, 48% of whom are women and 52% men. In sponsibility when it engages with stakeholders. As such, all new software tools.” aims to address. keeping with the Roche Group’s philosophy and approach, Roche employees receive compliance training. In 2015 Roche Ecuador Ecuador invests in its employees and seeks to create a rich and implemented a new compliance plan to increase ethics and in- • “Transforming Lives”: In December 2014 Roche Ecuador rec- stimulating work environment. tegrity trainings and refresh trainings in competence, business ognised the contributions of 25 Quito, Guayaquil and Cuenca Supporting Local Patient Organisations partners and harassment. Key suppliers are also invited to Roche physicians through a special project that included a video of Roche Ecuador was recognised as one of the best places to to attend trainings on several topics including compliance during the physicians’ family members talking about how they trans- Roche Ecuador engaged with and supported 10 patient support work in the country in 2014, receiving a total of six “Best Place an annual “Supplier Day.” form the lives of people every day. The videos were delivered organisations in 2014 and five in 2015 through 42,000 USD(34) in to Work” awards in the last 10 years. In 2015 the company was to every doctor along with a photograph of their family. financial contributions. Organisations supported include: Apare, again ranked first amongst Great Place to Work® companies in APO HCAN, Hope & Life, FAVCA, FEMAVI, Fibrosis Cuenca, the pharmaceutical industry, and second amongst all companies Fibrosis Guayaquil, Fibrosis Quito, HCAM Volunteering, Pro- of 500 employees or fewer. Smile, Cepreme and Youth Against Cancer Foundation.

(34) United States dollars

116 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 117 Watch video here Mexico

“Ultimately, it is the I am person who loves life and feels still has many things to learn people that make a from it. Some time ago, I was diagnosed with early breast cancer. My life changed radically. The treatment was hard – I had nausea company.” and lost my hair. But I realized that my resilience was greater than adversity. When I was diagnosed, my first and main fear was to Beatriz Mercedes Pardo Martínez go through the experience alone. But that was not the case, as I Site Development Manager at Roche Mexico received great support from my colleagues at Roche, where I have been working for the past 18 years.

On one occasion, in a chemotherapy cycle, my white blood cells Environment dropped to dangerous levels. This made me vulnerable to any serious infection. To counter this, I was prescribed with a medicine Roche Ecuador strives to reduce the indirect environmental im- that, unfortunately, was not available in pharmacies. What hap- pact of its activities through energy-saving policies, optimising pened then was that my colleagues, some of whom I did not even resource use and dedicated work in the areas of safety, health and know, started looking for the product, investing time and effort in I also feel proud of being able to collaborate in the development of protection of the environment. Roche continues to work towards a very supportive way, until they found it. They even brought it to new medicines. My job consists primarily of visiting hospitals and minimising the ecological footprint and environmental impact of my house, and one of my co-workers administered the medicine interviewing potential researchers, assessing their capabilities for our business and services through incremental investments, ac- to me. This allowed me to survive and strengthen my immune conducting clinical studies and providing them with training. By tions and awareness building activities. system in order to receive the next cycle of chemotherapy. Re- finding researchers and helping them build capabilities for trials, membering this situation makes me feel deeply proud of working I feel I am contributing to give other patients the same opportu- here. Because, in the end, it is the people that count. And I feel nity I had to recover from disease. very fortunate to be part of this great group of people.

118 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 119 Roche Mexico at a Glance Mexico City 1948 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 1,120 43.8% 33.3% 11.4% 2014 2014 2014 2014 1,121 45% 40.8% 13.1% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 233 13 9,266 8.3 2014 2014 2014 2014 148 19 13,383 11.9 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 71 71 Investment in R&D (mCHF)(35) 17 15

Number of Active Sites 293 245 Number of Employees in R&D 81 79

(35) Million Swiss francs Number of Patients 1,020 960 in Clinical Trials

Environment 2014 2015 Healthcare in Mexico Roche in Mexico

Energy Consumption (GJ) 172,658 188,255 Mexico has been working to bring universal healthcare coverage Roche has been present in Mexico since 1948. Headquartered in to the entire country through a national, public programme since Mexico City, Roche Mexico currently holds the fifth position in 2003. Currently 96.2% of the population has healthcare; howev- sales within the pharmaceutical market as well as the first posi- GHG Emissions (tons) 13,831 15,088 er, this insurance does not cover total care and public healthcare tion in the hospital segment (public and private). has suffered budget cuts in recent years. In spite of this situation, Water Consumption (cubic meters) 49,179 76,323 Mexico is working to ensure all citizens have effective access to Roche Mexico comprises Roche Services and Roche Products. quality health services regardless of socioeconomic status or geo- Roche Products includes the Pharmaceuticals, Diagnostics and graphic region. Diabetes divisions as well as a centre for Clinical Research. In ad- General Waste Produced (tons) 19 27 dition, the company has a production unit in Toluca. In Mexico cancer is the third leading cause of death; according Recycling (tons) 136 82 to the Health Ministry, there were 78,582 recorded deaths from At Roche we pioneer the advancement of science for humanity cancer in 2013. Access to treatment and early detection are key to help the world find better ways to prevent, diagnose and treat to improving care and patient outcomes. Currently, major urban disease. We believe that our role should not only be to develop the Paper Consumption (tons) 5 2 centres like Guadalajara, Monterrey and Mexico City host 60% solutions to today’s most critical diseases, but also to ensure that of the country’s oncologists, making access difficult for citizens all patients have equal access to treatment and diagnosis. Investment in SHE (CHF)(36) 372,000 2,710,000 living in other areas. As a result, oncology has become a major (Safety, Security, Health and Environment) priority in current national health reforms. (36) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

120 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 121 Roche’s primary focus Sustainability Initiatives in Mexico is promoting Access to Healthcare increased access to At Roche Mexico we focus on helping all citizens acquire access to the benefits of complete and innovative treatments with quality healthcare. medicine. We believe that equitable and sustainable solutions to today’s healthcare challenges can be achieved through persistent commitment and action by multiple stakeholders, including public authorities, non-governmental stakeholders, local communities and the healthcare industry.

We work closely with local partners and stakeholders to address Mexico’s specific needs, such as ensuring greater medicine access for the public. To help more patients and providers access our products, we provide three to five approved pharmaceuticals in each of Mexico’s four healthcare programmes that are covered and/or subsidised by the public sector. These pharmaceuticals treat six diseases including colorectal cancer, breast cancer, lymphoma, ovarian cancer, cervical cancer and hepatitis C. Recently, the magazine Executive World placed Roche Mexico in the “Top 20 Most Ethical Companies” and “Top 50 Most Socially Respon- sible Companies” in Mexico.

Roche’s primary focus in Mexico is promoting increased access to healthcare. To achieve this objective, we concentrate our activities around five areas: Delivering Innovation, Increasing Disease Awareness, Strengthening Healthcare Infrastructure, Improving Affordability and Supporting Local Patient Organisations.

Delivering Innovation

Roche Mexico invested more than 365 million MXN(37) in clinical research to drive medical advancement over a two year period in 2014 and 2015. In 2015 alone we were involved in 71 studies, with half focused on oncology and half addressing immunology, infectious diseases, ophthalmology and neurology. These studies included 960 patients across 245 research sites.

Roche Mexico also continued to host the “Dr Jorge Rosenkranz Award” for medical research. Launched in 1984, the award aims to spur innovation and encourage scientific research in Mexi- co. Every year we invite researchers from leading institutions to submit original research conducted in Mexico for consideration. The magazine Executive World placed The Rosenkranz Award is one of the most widely recognised awards for Mexican scientists, and its recipients have made Roche Mexico in the “Top 20 Most incredible contributions to health and welfare in Mexico and around the world. Ethical Companies” and “Top 50 Most Socially Responsible Companies” (37) Mexican pesos in Mexico.

122 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 123 Increasing Disease Awareness

Even with the most advanced treatment available, failure to di- • “Two Shades of Ovarian Cancer” campaign: Activities in- agnose diseases in an early stage can significantly impact the cluded an exhibition called “Life Stories of Ovarian Cancer,” success of treatment. Late diagnoses and obstacles to acquiring a press conference where participants were invited to join the treatment are some of the greatest barriers Mexico’s healthcare campaign via social networks, and an awareness walk to the system faces today. In order to break down these barriers, we Milan Theatre where a play about ovarian cancer was per- have been working with the government and non-government formed. The campaign, held in partnership with the Mexican organisations (NGOs) to increase public education around Association for the Fight Against Cancer (AMLCC) and Gy- Mexico’s leading diseases while supporting patients seeking and naecological Cancer Research of Mexico (GICOM) appeared undergoing treatment. in 60 publications, reaching an estimated 7.3 million people.

In 2014 and 2015 Roche Mexico conducted eight disease aware- • “Cervical Cancer: Closer than it Appears” campaign: De- ness campaigns, reaching more than 20 million people. These spite government priorities for cervical cancer prevention, initiatives included: screening and treatment, there are very few options for patients with advanced stages of the disease. To raise awareness • “Medical Update Journalism Seminar”: Launched by Roche for this issue, Roche Mexico supported a social media cam- Mexico in coordination with the Pan American University, the paign with AMLCC and Pasteur Foundation targeting key seminar aims to increase journalistic fluency in medical topics stakeholders in the government, media, NGOs and physician and ensure journalists have access to the latest information. communities. The campaign reached more than four million In 2014 and 2015 Roche Mexico hosted two editions of the people in less than one week, and as a result, two agreement seminar, made up of 15 free sessions each, given by professors documents were submitted to the Ministry of Health asking and panellists from the Pan American University, the semi- the organisation to focus on and properly attend to patients nar emphasises the importance of specialisation, research and with advanced cervical cancer. promoting health information. Representatives from public and private institutions also participated and conducted peri- • “World Transplant Day” initiative: In 2015 Roche Mexico, in odic evaluations to endorse and improve the course. A total of partnership with the Mexican Institute of Nephrological Re- 32 journalists participated in the second edition celebrated in search (IMIN) and the National Transplant Centre (Cenatra), 2014, while the number of participants increased to 39 for the carried out a national campaign on June 6, World Transplant third edition in 2015. Day. Roche held a press conference and expert panel to raise awareness about organ transplantation and to foster a culture • “Pinking about You” and “Celebrate Life” campaigns: Roche of organ donation in Mexico, bringing new hope to the near- Mexico and L’Oreal partnered to create “Pinking About You,” ly 20,000 Mexicans currently awaiting organ or tissue trans- a campaign to raise awareness about breast cancer prevention plants. and treatment. As part of the campaign, they also launched a digital campaign, “#Celebralavida,” in partnership with Glam- • “Cystic Fibrosis National Crusade”: Roche Mexico launched our Magazine to expand awareness even further. a national awareness crusade with the Mexican Association for Cystic Fibrosis about the positive impact timely diagnosis and proper treatment can have for patients. The campaign was designed to share information on the disease and its treatment with the general public, and to support market access through strategic communications at health institutions. The campaign was covered in 73 publications, reaching an estimated 8.57 In 2014 and 2015 Roche million people. Mexico conducted eight • Hepatitis C social media campaign: To support the World Health Organisation’s goal to eliminate hepatitis C by 2030, we disease awareness partnered with the Mexican Foundation for Hepatic Health (FundHepa), the Self-help Group United for a Better Life campaigns, reaching more and the Hepatos Aión Foundation to create a social media campaign that raised government, media, NGO and hospital than 20 million people. awareness for the importance of early detection and treatment for hepatitis C.

124 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 125 Supporting Local Patient Organisations

Recognising the great work of local patient support programmes, • Pasteur Foundation: We worked with Pasteur Foundation to we engaged and supported 12 NGOs throughout 2014 and 2015 develop a campaign around early detection and prevention for Strengthening Healthcare Infrastructure with donations totalling nearly 440,000 USD. We also provided cervical and breast cancer. collaborative support to a number of organisations, including: At Roche Mexico we strive to support healthcare practitioners • Mexican Association of Cystic Fibrosis (AMFQ): Partnering and industry professionals to advance healthcare throughout the • Mexican Association for the Fight Against Cancer: In col- with the National Institute of Perinatology and the AMFQ, We supported 75 country. We supported 75 events during 2015 on topics such as laboration with AMLCC, we provided support through aware- Roche helped to raise awareness among the general population cancer, arthritis, hepatology, organ and tissue transplants and ne- ness campaigns and advocacy projects for ovarian, cervical about the importance of an early diagnosis for cystic fibrosis. A events during 2015 on phrology. We also invested 2.2 million USD(38) in events specifi- and breast cancers. Straw Challenge drove awareness through social networks and cally supporting physician education and training. 300,000 MXN in sponsorships were awarded to NGOs during topics such as cancer, • Ale Association: We worked with Ale Association to support the campaign’s activities. Roche Mexico also worked with the three patient information events, the development of an annu- Ministry of Health to expand support for a cystic fibrosis neo- arthritis, hepatology, Improving Affordability al report publication and awareness for National Transplant natal screening, increasing funding for the diagnostics test. Day. We also hosted the Second Quality Forum, which focused transplants and Roche adapts its healthcare strategy to meet the greatest needs on moving toward a “whole public policy on pharmaceuticals.” in the markets in which we operate. As such, affordable products The event brought together patients, health authorities, regu- nephrology. and diagnosis are in great demand within Mexico, an area that lators, and NGOs to discuss the quality and security of biolog- Roche aims to address. ical treatments, ethics and patient security.

(38) United States dollars

126 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 127 Employees We are proud to have Roche Mexico has 1,121 employees, 45% of whom are women been recognised by Great and 55% are men. Our steering committee is 30% women, compared to the national average of 7%, and 40% of Roche Mexico Place to Work® for gender managers are women, compared to the national average of 23%. We are proud to have been recognised by Great Place to Work® equality. for gender equality.

In terms of compensation, the lowest salary paid by Roche Mexi- co in 2015 was four and a half times the minimum wage. We have also been recognised by Forbes Mexico as one of the top 25 companies for work-life balance, and Universum Publicius named Roche Mexico one of the most attractive employers for students.

Wellness Civil Institutions Roche Mexico continued to support and implement our “Live • Mexican Association of Pharmaceutical Research Industries Well” programme through monthly offerings and a well-being (AMIIF) week that promoted prevention practices such as eye exams and • Mexican Centre for Philanthropy (Cemefi) health screenings, vaccines, breast cancer early detection aware- • Mexican Association of Organisational Communicators ness and HPV screenings. The Live Well programme also pro- (AMCO) vides emotional well-being resources to improve stress management and healthy lifestyle offerings such as cooking classes and All active employees completed mandatory e-learning trainings an urban gardening workshop. throughout 2014 and 2015. Externally, Roche Mexico conducted trainings with three suppliers in 2014 and increased trainings to seven in 2015, in addition to an annual supplier audit. All sup- Governance pliers are subject to the Code of Conduct and receive training at “Supplier Day.” Following the Group’s guidelines on Corporate Governance, Roche Mexico sets parameters to ensure that all staff members and business managers remain aligned with the company’s ethi- Communities cal principles. In both 2014 and 2015, Roche Mexico was named one of the top 100 companies by reputation and corporate gover- We remain committed to the communities in which we operate nance by the Business Monitor of Corporate Reputation (Merco), and focus local investment on science and education, and social moving up 65 places from 2014 to 2015. campaigns such as:

During 2014 and 2015, Roche Mexico created a managerial po- • Promoting blood donations in collaboration with the Mexican sition specialising in government relations and public policy to Red Cross work specifically on related issues. Roche Mexico partners with the following civil and governmental organisations: • Driving awareness for available flu vaccinations

Government • Developing materials to demonstrate the proper disposal of • Ministry of Health expired medicines and batteries • Mexican Social Security Institute (IMSS) • Institute for Social Security and Services for State Workers Notably, Roche Mexico employees were encouraged to increase (ISSSTE) participation and beat their donation goal at the annual Roche • Pemex (State Oil Company) Children’s Walk. Proceeds from the walk benefited Friendship • Popular National Health Insurance Programme Home, a local NGO that supports children with cancer; publicity • Ministry of Environment and Natural Resources (Semarnat) around the event promoted early detection and proper treatment • Senator Chamber (Health Commission) for childhood cancer. Roche donations covered the equivalent of • Deputies Chamber (Health Commission) three cancer treatments in 2014, and increased to cover as many • Ministry of National Defence (Sedena) as seven treatments in 2015. • Ministry of Navy (Semar) • Federal Prosecutor for Environmental Protection (Profepa)

128 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 129 Going forward, we see Watch video here Peru energy and resource Environment efficiency as a major Roche Mexico continues to work towards minimising the eco- area of opportunity. “Thanks to all the great logical footprint and environmental impact of our business and services through incremental investments, actions and awareness research, I have a second building activities. Going forward, we see energy and resource efficiency as a major area of opportunity. Roche hopes to improve I am a very happy person, I like to smile and enjoy life. Even chance to live.” energy efficiency onsite, move toward sustainable building prac- though I have had many falls, I have always overcome the hurdles tices, increase renewable energy acquisitions such as solar pan- and moved forward. Mónica Sandoval Apuerta els, upgrade our waste water treatment plant, and reduce overall Breast cancer patient waste generation. In 2014, it happened that, between one thing and another, as it often happens in life, I missed a medical check-up. And then, breast Noteworthy programme achievements include: cancer overtook me. Had the doctors not acted quickly, I think I would not be here today. From a cyst when it was detected, it • In 2014-2015 Roche worked to eliminate hydro-chloro-flu- • Roche Mexico conducts trainings on health, safety and envi- evolved into cancer by the time of the surgery. And only three orocarbon (HCFC) and hydrofluorocarbon (HFC) refriger- ronmental protection. months had passed. ants, which can negatively impact the environment. Roche is replacing HCFC and HFC refrigerants with natural refriger- • Roche participates in the EHS Pharma Group, which brings The most difficult moment was when I got the diagnosis. I kept I am most grateful to the doctors who have treated me and for ants, such as R717/ ammonia. In our efforts to reduce harmful together Mexico’s top pharmaceutical companies to exchange asking myself: “Why me?” I also had a crisis after I had the sur- the medicine I am receiving. It is thanks to the days and nights substances that may contribute to ozone depletion and climate best practices on environment, health and safety topics. gery, out of fear that the tumour might still be there. Fortunately, scientists dedicated to discover this treatment that I can be here change, we installed a new system at our facility with different I had very good doctors. And I have also been fortunate to be today. And I know I still have a long way to go, a third cycle of refrigerants, new technology and brand new air handing, pip- • The “4R” project, launched in 2013, continues to show success. part of a patient support programme. The treatment that I am treatment with doses every 21 days for 12 months. But I’m not ing, drainage, electrical, instrumentation and control systems. The programme promotes efforts to Reduce, Reuse, Recycle receiving has given me a second chance to live. The tumour I have afraid, because the needles might hurt a little, but I know I will As Mexico lacks access to the technology needed to meet these and Re-educate across Roche Mexico. is very aggressive and still it has responded well to the treatment. be fine. And then, keep on going, listen to the doctor, and never requirements, Roche had to import equipment from the Euro- I feel healthy and strong. miss a check-up. pean Union.

130 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 131 Roche Peru at a Glance Lima 1961 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 180 55.6% 18.2% 11.2% 2014 2014 2014 2014 189 58.2% 13.3% 17% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 29 4 3,264 14 2014 2014 2014 2014 41 7 3,244 16 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 35 33 Investment in R&D (mCHF)(39) 2 5

Number of Active Sites 127 118 Number of Employees in R&D 35 35

(39) Million Swiss francs Number of Patients 353 199 Healthcare in Peru in Clinical Trials Peru’s 31 million inhabitants receive healthcare coverage under • Private Insurance: Providing coverage to 7% of the popula- four separate health systems: Ministry of Health, Social Security, tion, private insurance companies have been rapidly vertical- Environment 2014 2015 Armed Forces and Police and Private Insurance. ly integrating, and will play an increasingly important role in closing the public sector’s coverage gaps. Energy Consumption (GJ) 27,191 6,164 • Ministry of Health (MINSA): The Ministry of Health covers 58% of the population, including individuals with low-income Project Hope: and informal jobs who, historically, have lacked adequate ac- In Peru decentralising access to quality oncology services re- GHG Emissions (tons) 1,911 382 cess to medical care. In 2012 president Humala announced mains a major challenge. The doctors and infrastructure required a publicly funded oncology insurance programme, “Project to provide exams and treatments are concentrated in urban areas Water Consumption (cubic meters) n/a 519 Hope,” to provide cancer treatments to the poorest population. like Lima, Arequipa, Trujillo and Cusco, with 85% of oncologists Although significant progress has been made since Project in Lima alone. As a result, rural residents suffer higher rates of Hope’s launch, major challenges and barriers to access remain. illness and mortality from cancer. Launched in 2012, Project General Waste Produced (tons) n/a n/a Hope aims to reduce these rates by providing access to modern • Social Security (EsSalud): Covering 30% of the population, treatments for all individuals, regardless of location and socio- Recycling (tons) 1 n/a Social Security strives to provide healthcare for all citizens economic status. The programme is government-led and, when with formal employment. However, ongoing budget shortfalls fully implemented, would provide access to almost 18 million Pe- and an increasing demand for Social Security services have re- ruvian men and women. Paper Consumption (tons) 1 n/a sulted in limited access to some treatments.

Investment in SHE (CHF)(40) n/a n/a • Armed Forces and Police: Individuals in the armed forces (Safety, Security, Health and Environment) and police, who constitute about 5% of the population, receive (40) Investment ﬁgures in Swiss francs and also include the Diagnostics Division healthcare coverage that in some cases, extends to their family members as well.

132 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 133 Roche Peru’s strategy is framed around the concept of “Passion.”

Sustainability Initiatives Access to Healthcare

Roche Peru strives to find reasonable and sustainable solutions to the current challenges in Peru’s healthcare system, ensuring that all citizens have access to the benefits of complete and innovative treatment. We currently have 15 products covered and/or subsidised by the public sector for various approved treatment uses in Peru and hope to bring more to market.

In parallel with our effort to expand healthcare coverage, we work to enhance the current infrastructure and capabilities of the healthcare system while driving funding for new medicines. To promote healthcare access, we actively engage in efforts based on the five pillars of the Group: Delivering Innovation, Increasing Disease Awareness, Strengthening Healthcare Infra- structure, Improving Affordability and Supporting Local Pa- tient Organisations.

Delivering Innovation Roche in Peru Roche Peru invests in clinical studies to advance healthcare, with Headquartered in Lima, Roche has been in Peru since 1961, serv- Roche Peru aims to expand infrastructure and capabilities within We work to enhance the the goal of creating and developing medicines and diagnostics to ing the public and private markets through its Pharmaceuticals the industry and drive funding for new medicines to ensure the meet people’s health needs and improve quality of life. Over the and Diagnostics divisions. With a focus on patient care, Roche public healthcare system is capable and prepared to deliver bio- current infrastructure two-year period between 2014 and 2015, we invested a total of 7.3 Peru contributes to Project Hope through educational cancer logic oncology medicines. Roche Peru strives to: million USD(41) in clinical trials. In 2015 we conducted 33 clinical awareness campaigns, strengthened diagnostic testing, medicine and capabilities of the trials impacting 199 patients. pricing assistance and the establishment of new healthcare facil- • Drive adoption of innovative medicines in Peru; ities. • Deliver sustainable access to healthcare; healthcare system while • Develop long-term partnership with private insurance; Roche Peru’s strategy is framed around the concept of “Passion.” • Ensure a competitive and sustainable organisation; driving funding for new (41) United States dollars This approach encompasses all company initiatives to deliver • Ensure fair and transparent regulatory and approval framework. commercial and organisational success, as well as the company’s medicines. approach to corporate responsibility and social welfare. Roche Peru believes in compliance, accountability, teamwork, professional development, transparency and inclusion.

134 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 135 Increasing Disease Awareness

At Roche Peru we believe that better education and awareness Patient Day: about various diseases is critical for patients to detect early symptoms and learn more about available treatments, as well as best In July 2014 Roche Peru held its first “Patient Day” in part- practices for prevention. In 2014 Roche Peru conducted more nership with the Peruvian Society of Oncology. At this than 35 disease awareness initiatives with a heavy focus on on- event 170 patients attended lectures by oncology experts on cology, reaching more than 800 people. We increased our aware- topics including patient rights and duties, risk factors and ness initiatives in 2015 to more than 40 campaigns, reaching over disorders associated with cancer, sexuality and psychology. 1,200 people. Following 2014’s success, Roche Peru held its second annual “Patient Day” in August 2015, attracting more than In addition to our awareness campaigns, we also develop and 250 attendees and featuring renowned experts in nutrition, support our own patient initiatives. In 2014 we conducted 15 psychology and oncology. “Patient Day” gives participants patient support programmes, reaching more than 600 patients. the opportunity to ask health experts questions and address We were able to increase support in 2015 with 25 patient support concerns about their disease and treatments. It also encour- programmes, reaching more than 750 patients. ages stakeholders to join forces and establish networks that support patients’ access to timely and accurate diagnosis In its eighth year, “Roche Life” continues to support and empower and treatments. patients with the information and tools that they need to tackle any health challenge. The programme provides a variety of services including diagnostic tests, out-of-pocket service, co-payment, management coordination of the letter of guarantee and guidance service. “Roche Life” also creates a safe space for patients to access emotional support tools, as well as express and channel their emotions.

136 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 137 Roche remains involved in several programmes that address key issues such as basic infrastructure, medical education and training.

Strengthening Healthcare Infrastructure In partnership with the Peruvian University of Applied Sciences Supporting Local Patient Organisations (UPC), Roche Peru also developed “Join In,” a comprehensive, Roche aims to remove barriers in the current healthcare system five module training programme for more than 600 healthcare To expand our reach beyond our own initiatives, Roche Peru and increase access to basic healthcare in the regions where it providers in seven hospitals across Lima, Trujillo and Arequipa. collaborates with and provides support to patient programmes operates. In this role, Roche remains involved in several pro- The five modules covered patient care and Project Hope coverage, focused on ensuring people have the best care possible. Over the grammes that address key issues such as basic infrastructure, an introduction to biologic medicines, health management pro- two year period between 2014 and 2015, Roche Peru contributed medical education and training. cesses, evidence-based medicine and biologic therapies. to five patient organisations (Mother’s Club, Fiqui Peru, Oncovi- da, Light of Hope and ALINEN), providing financial contribu- Recognising that the Ministry of Health (MINSA) does not cover tions that totalled 8,500 USD. advanced cancer diagnostics, Roche partnered with four public Improving Affordability hospitals to improve and promote early and accurate diagnosis of In partnership with the UPC, patient associations and suppliers, breast cancer through pathologic immunohistochemistry (IHC) To help Peruvians overcome obstacles and access the healthcare we developed the “Voices in Action” campaign to empower and tests. To support coverage of IHC tests, Roche Peru established they need, we must adapt to the realities of the market – includ- support patients on relevant issues such as patients’ rights, medi- a tripartite partnership among Roche, the hospital and private ing affordability. To address this area, Roche Peru has formed cine of last generation and effective communication. laboratories, where we personally assume the cost of the extra and maintained alliances with three of the largest private sector tests and coordinate the programme’s set up and management. health insurance companies in the country to generate improve- The programme is currently active in four MINSA hospitals, in- ments in diagnostics, professional training and medication pric- cluding Archbishop Loayza National Hospital, Hipólito Unane es. These partnerships make it possible to reach a greater num- Hospital and Cayetano Heredia Hospital in Lima, as well as Goy- ber of people with the best treatments available and help offer eneche Hospital in Arequipa. more affordable prices for treatment.

138 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 139 Employees Governance

At Roche Peru we employ 189 people, of whom 42% are men and All regional companies in Latin America, including Roche Peru, 58% are women. We believe that the development of our staff is follow the Group’s guidelines on Corporate Governance. The not only critical for business success, but also an important part highest governing body presently has seven members and the of their personal and professional growth. During 2014 and 2015 president holds the position of General Manager. we carried out more than 50 employee initiatives benefiting more than 120 employees. Beyond our internal team, we also closely monitor our suppliers. In 2014 and 2015 we administered five supplier audits. In 2014 One such employee initiative, our “Live Well” programme, seeks we launched “Supplier Day,” a six-day training opportunity on the to embed healthy lifestyle habits in all Roche employees. To cel- Code of Conduct and other key topics. We also offer an online ebrate “Well-being Week,” Roche Peru partnered with a num- Code of Conduct training for all new suppliers and administered ber of vendors to provide free services for our staff. Employees 50 online courses in 2014, and another 31 in 2015. also offered their own talents – from dancing to healthy cooking and yoga to lectures for colleagues. In a survey conducted after “Well-being Week,” 95% of employees were satisfied with the ex- Communities perience. At Roche Peru we allocate our investments to create social value We also offer a variety of general benefits to all employees includ- in three areas: childhood, education and community. In 2014 we ing: school fee support and family allowance, maternity leave, conducted four community initiatives and increased our actions health, vehicle and life insurance, holidays and vacation bonuses, to six initiatives the following year, benefitting nearly 3,000 peo- cell phone and computer equipment, an on-site employee dining ple over the two-year period. During this time, we continued to area, post-graduate education support, product discounts from support the district of Chocos in their recovery from a devastat- Roche and partner companies, social committee events, early ing earthquake in 2007 by helping people rebuild their homes and leave Fridays all year, loan access and five-year recognition. improving the local economy. In partnership with the Peruvian Social Fund (Focondes), a modern irrigation system was also in- In 2015 Roche Peru conducted several internal meetings and dis- stalled together with a dam to provide water in the dry season. tributed a survey to define its Diversity & Inclusion (D&I) strategy, with the support of employees. As a result of this inclusive To support local education, we forged a partnership with The process that created a space for discussing diversity, two focus Recreation Project to introduce the “Reader Plan” in Chocos, areas were defined: appreciation of different thinking styles and providing more than 1,000 books for children and adolescents. openness to new opinions and ideas. Roche Peru employees be- A partner campaign, “Let’s Play Reading,” also provided training lieve focusing on these two areas will increase our capacity for and monitoring for parents and teachers to create positive read- innovation and help us achieve our goals in a highly changing ing habits. commercial environment, while creating a positive environment to develop and reinforce engagement.

140 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 141 Uruguay

“Clinical trials mean access to knowledge for physicians and to I was the first in my family to study medicine. I have always been treatment for patients.” a people’s person, passionate about helping. Now I have been an oncologist for 23 years. And as I focus on breast cancer, I have Isabel Alonso had the opportunity to participate as the principal investigator Oncologist in the SafeHer clinical trial. Our aim was to compare the new subcutaneous formulation of a cancer medicine to the existent Environment intravenous preparation.

Roche Peru’s offices are eco-friendly and are built on principles that We take pride in our Lima headquarters, which received the Lead- The main difference we noticed was that, with the intravenous Clinical research has the power to open our minds, and allows respect the environment. We are in the process of implementing a ership in Energy & Environmental Design (LEED®) Gold Certifi- formulation, the patient had to stay in the hospital for one hour us physicians to learn about the latest innovations. And for many recycling system that will promote positive habits for employees cation in commercial interiors in 2010. As part of this recognition, and a half, and then wait another while to make sure there were patients, trials are the only way to access treatment. The SafeHer both at work and at home. the U.S. Green Building Council considered the building’s low level no allergic reactions. With the subcutaneous formulation, within study, for example, has served as a precedent in Uruguay. Fol- of water and energy consumption, together with the high quality half an hour the patient can go home. For anyone, and particu- lowing its results, the National Resources Fund introduced the and comfort of the workplace, the efficient waste and emissions larly for a patient, the longer you can stay away from the hospital, subcutaneous formulation in the list of covered cancer medicines. management systems, as well as the reduced impact on the terrain. to be with your family and go on with your life, the better. For The office also uses recycled furniture and has a layout that favours us doctors and the hospital, the subcutaneous formulation has With research, we are making great steps forward for the benefit natural lighting. also shown logistical advantages in that, for instance, it is easier of patients. We are on the right track but there is still much prog- to store. ress to be achieved. In this effort, the support of research-oriented companies is simply essential.

142 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 143 Roche Uruguay at a Glance Montevideo 1947 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 110 47.3% 25% 13.3% 2014 2014 2014 2014 117 49.6% 30% 12.3% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 32 5 1,363 12.5 2014 2014 2014 2014 21 9 2,653 17.6 2015 2015 2015 2015 Roche in Uruguay

Headquartered in Montevideo, Roche has been present in Uru- Clinical Trials 2014 2015 Research & Development 2014 2015 guay since 1947. The company also covers the markets of Bolivia and Paraguay. In Paraguay, Roche works through an exclusive Number of Clinical Studies 6 5 Investment in R&D (mCHF)(42) 13 8 distributor, while in Bolivia a new Marketing Services Organi- sation is being established to manage logistics and distribution. Number of Active Sites 12 11 Number of Employees in R&D 9 9 Healthcare in Uruguay Roche Uruguay also functions as the logistics, regulatory affairs and quality hub for the entire Latin American region. Roche Uru- (42) Million Swiss francs Number of Patients 14 14 Uruguay’s National Integrated Healthcare System (SNIS) has ac- guay is currently the No. 1 provider in the oncology market and in Clinical Trials tively provided health insurance to all workers and retirees, as the primary supplier to the National Resources Fund (FNR), a well as their families, since 2007. The SNIS is financed by the Na- non-state public entity created by Decree Law 14,897. In 2015 tional Health Fund (NHF), which is in turn financed by employ- Roche Uruguay was recognised as the No. 7 pharmaceutical com- Environment 2014 2015 ee and employer contributions and supplemented by government pany in Uruguay. funds. Currently only 30% of Uruguayans use public healthcare Energy Consumption (GJ) 21,601 8,411 as local private firms dominate the healthcare market in the coun- In 2014-2015 Roche Uruguay received approval for the use of a try. Those who benefit from the state system have the opportunity number of drugs and indications to treat diseases including ovar- to choose between accessing services through state hospitals or ian cancer, early stage breast cancer and cervical cancer. GHG Emissions (tons) 1,528 593 private firms.

Water Consumption (cubic meters) 2,088 849 Across the region, the healthcare sector is working to increase access to care and identify new alternatives for reaching lower Bolivia medical prices that are more affordable. Health professionals General Waste Produced (tons) 8 7 have projected that there will be a 12.2% increase in cancer cases Bolivia remains a key area of opportunity and potential within Uruguay by 2020, making greater access to screening and growth for Roche Uruguay with a population of 11 million Recycling (tons) 25 14 oncology services a major priority. To address this issue, Uruguay people, high economic growth and a need for better health- has initiated studies in pharmaco-economics (the analysis of the care access. As such, Roche proposed a new legal entity in cost-effectiveness of medications) to inform future healthcare de- Bolivia, the Marketing Services Organisation. This new en- Paper Consumption (tons) 15 7 cision making and enable decision makers to consider the total tity will provide marketing services to the Roche Interna- cost involved in a treatment, including direct and indirect ex- tional Ltd. Montevideo branch, working to establish a local Investment in SHE (CHF)(43) 2,000 1,000 penditures. This method of registering financial impact provides presence, obtain a competitive position and develop robust (Safety, Security, Health and Environment) more effective control of expenditures, which minimises costs market access strategies. (43) Investment ﬁgures in Swiss francs and also include the Diagnostics Division and allocates investments where they are most needed.

144 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 145 Sustainability Initiatives Access to Healthcare

To promote access to healthcare in Uruguay, Roche conducts • Supporting the “HER2 Incidence: Real World Data” initiative, initiatives based on the Group’s five pillars: Delivering Inno- which aimed to measure the impact of breast cancer locally vation, Increasing Awareness, Strengthening Healthcare Infra- and to fill the knowledge gaps in terms of healthcare burden, structure, Improving Affordability and Supporting Local Pa- while building up educational activities and supporting the ac- tient Organisations. cess of an increasing number of patients to targeted therapies. More than 2,800 patients were included in the survey.

Delivering Innovation • Offering specialised preceptorships for young physicians to expand access to basic learning tools that help healthcare At Roche Uruguay our goal is to improve healthcare through professionals apply medical advances in their day to day medical education, increased access to advanced information practice. Participation in these activities increased in 2015 and driving cutting-edge treatments. Throughout 2014 and 2015, due to the excellent feedback received from physicians who Roche Uruguay invested nearly 230,000 USD(44) in 11 clinical tri- participated in 2014. als to advance available treatments for breast cancer, non-Hod- gkin’s lymphoma, chronic lymphocytic leukaemia and rheuma- • Hosting 125 in-person attendees (and many more online) at toid arthritis. the first “International Congress of Onco-Haematology” to discuss the latest therapeutic options in immunotherapy and Recognising that increased access to information will drive inno- treatment for breast cancer, melanoma and chronic lympho- vation, Roche led multiple initiatives in this area, including: cytic leukaemia.

Throughout 2014 and 2015, Roche • Creating the global “Online Colorectal Cancer Forum,” a ven- • Continuing to support an extensive molecular testing and per- ue for more than 150 physicians in Uruguay, Bolivia and Para- sonalised medicine programme around HER2 breast cancer, Uruguay invested nearly 230,000 USD guay to share clinical data and cases with healthcare providers non-small cell lung cancer and melanoma to facilitate prompt from all over the world. The Forum also developed an online and accurate diagnosis and targeted therapies. Over the last in clinical trials. molecular oncology course for physicians and celebrated in- year, Roche Uruguay focused specifically on reducing the novative thinking by offering the participant with the highest amount of time required to analyse diagnostic samples. score at the end of the course an internship at the Clinic Hos- pital of Barcelona in Spain.

(44) United States dollars

146 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 147 Increasing Disease Awareness

Roche Uruguay believes that better access to diagnostics and medicine as well as better education on various disease symptoms are vital to reduce the country’s mortality rate and improve patient care everywhere. To help increase disease awareness, Roche supported campaigns for colon, ovarian, breast, cervical and lung cancers, as well as lymphoma, arthritis and hepatitis. Roche Uruguay also amplified national events for World Cancer Day, Survivor Day and International Women’s Day (focused on breast cancer) in 2014 and 2015. We increased our support from eight campaigns in 2014 reaching more than two million people to all 11 campaigns in 2015, reaching nearly three million people. In fact, Roche was the only pharmaceutical company in Uruguay • Driving breast cancer awareness through major campaigns. In that promoted awareness for colon cancer, ovarian cancer, lym- 2014 Roche sponsored the national “Breast Cancer Does Not phoma, hepatitis, arthritis, lung cancer and Survivor Day. Discriminate. Know Yourself to Love Yourself,” an initiative to raise awareness of the importance of breast self-examina- In November 2014 Roche Uruguay launched its Patient Support tion and early diagnosis for all women. Roche also organised Portal website. The Portal was created in alignment with the a meeting with female journalists to discuss the latest advanc- “One Awareness” concept, which aims to concentrate Roche’s es in treatment. In 2015 Roche Uruguay partnered with the efforts in one place where people can access information about Civil Association for Breast Cancer Rehabilitation (Ripama), different diseases and their preventive measures. The Patient the Give Me Your Hand Association, Honour Life Group and Support Portal provides information about lymphoma, arthritis, the Clarita Berenbau Foundation to raise awareness on the im- hepatitis, cystic fibrosis and lung, kidney, ovarian, skin, colon portance of breast cancer prevention, detection and treatment. and breast cancers, and allows visitors to access valuable data Together, they launched the “Let’s Add a Longer Life” cam- about the diseases’ symptoms, diagnosis, early detection, and paign, which displayed a giant pink hourglass in iconic loca- treatment options. The site also provides information on up- tions across the city to represent breast cancer survivorship. In coming education and awareness events such as breast cancer October Roche employees also painted the emblematic letters awareness month activities. of the Montevideo city sign in pink to raise awareness about breast cancer. In 2014 and 2015 the majority of Roche Uruguay’s campaigns focused on oncology, including: • In a creative approach to raise awareness about lymphoma and the importance of early detection, Roche partnered with 12 • Publishing “50 Years of Oncology in Uruguay,” a book that local artists to capture patients’ state of mind and emotions chronicles the development of oncology in the country and on mannequins in the “Express Your Feelings” campaign. The the pillars supporting its progress. The book was the result of pieces were later auctioned to raise funds for patient support an extensive research project involving more than 30 inter- associations. views to renowned oncologists, haematologists, radiologists, surgeons and mastologists discussing how new treatments and • In November 2015 Roche Uruguay partnered with the Honor- technologies have changed cancer’s perception and improved ary Commission for the Fight Against Cancer in the “Cycling patients’ quality of life. Full Speed against Lung Cancer” campaign. During a soccer game between the two top teams in Uruguay, the players en- tered the field wearing t-shirts and hats showing the dramatic increase in lung cancer cases among women in the country and, for the first time in history, cycled the “Olympic round” on the field.

• To celebrate World Survivors Day, Roche Uruguay organised a photographic exhibition called “My Return to Life,” conducted in partnership with the Livestrong Foundation. The exhib- it received nearly 2,000 visitors and aimed to raise awareness about the importance of innovation and medical advances to help extend survival and improve patients’ quality of life for a variety of cancers.

148 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 149 Supporting Local Patient Organisations

In 2014 Roche Uruguay created a Market Access department to help patients access the medications they need as quickly as possible. Since establishing the department, Roche has engaged several healthcare providers to raise awareness of the important role they play in helping patients access and successfully complete the treatments they need. This work has already reduced the number of days it takes patients to access their medications.

Through collaboration with local patient organisations, Roche has the ability to extend resources to further provide optimal patient care beyond the products we develop. In 2014 Roche supported nine patient organisations and increased support to 10 patient organisations in 2015. Roche Uruguay’s patient support programmes reached a total of 920 patients during this period. Some of these initiatives included:

• The Inaugural Cancer Patient Forum, a collaboration between Roche and the Uruguayan Medical Association (SMU), brought together 85 patients in a forum covering topics such as navigating the health system as a cancer patient, the vital role of patient groups, advocacy, the right to timely, quality diagnosis and treatment, and the benefits of clinical trials.

• In collaboration with the Health Foundation, Roche hosted a series of five trainings and discussions for oncology nurses covering topics such as holistic care for patients and efforts to improve patient care.

In addition to these initiatives, Roche Uruguay partners with a variety of groups to support efforts to simplify patient access to Strengthening Healthcare Infrastructure Improving Affordability vital oncology medicines and treatments, help patients navigate the healthcare system, remove barriers that limit access to quality Uruguay’s healthcare system is complex, and there are many ways Roche Uruguay supported two initiatives in 2014 and again in Roche Uruguay’s approach to healthcare is carefully developed healthcare, democratise healthcare system information, facilitate for Roche Uruguay to support and simplify its infrastructure. 2015 to help patients navigate the intricate healthcare system and to overcome barriers to local access and meet the needs of the collaborative environments at healthcare institutions and im- gain better access to the care they need: markets in which it operates. These barriers vary depending on prove disease awareness and prevention. Key partners in these To improve on-going medical education, Roche worked with income levels, disease epidemiology, political commitment and initiatives include: the Health Foundation, National Fight Against healthcare professionals to train 433 physicians through pre- • During World Hepatitis Day, celebrated on July 28, Roche resource allocation, as well as insurance coverage and the quali- Cancer, Ripama, Give Me Your Hand Association, Honour Life ceptorships, the Online Forum for Colorectal Cancer, the First Uruguay launched a partnership with the Military Hospital ty of healthcare infrastructure. Group, Clarita Berenbau Foundation, Lymphoma Group of Uru- International Congress of Onco-Haematology and an online of Montevideo to provide quick diagnostics for hepatitis C at guay, Porsaleu, Clamar and Aid Melanoma Uruguay. Molecular Oncology Course. We also offer physicians and other no cost. The initial 2014 campaign benefitted more than 200 In pursuit of better access to healthcare, Roche maintains its healthcare professionals relevant information on health issues, people and Roche increased support to 300 tests in 2015. The long-term agreement with the National Resources Fund (FNR) clinical studies, medical advances and congresses, among oth- initiative was accompanied by a disease awareness campaign to provide financial coverage for highly specialised medical pro- ers, to promote disease prevention through the online “Diálogo to drive long-lasting effects. cedures and expensive drugs for all Uruguayans that are part Roche” portal. of the Integrated National Health System. The FNR agreement, Roche Uruguay’s patient • To help patients better navigate the complex healthcare sys- first established in 2011 for lung cancer treatment, allows Roche tem and access proper, timely treatment after diagnosis, Roche Uruguay to continually explore innovative treatments and pro- support programmes Uruguay launched a National Access Forum. In 2015 the sec- mote access to the latest, most effective pharmaceuticals for all ond edition of the Forum gathered more than 100 participants patients. reached a total of 920 to share experiences navigating the healthcare system and featured a series of presentations on topics including: medica- patients between 2014 tion coverage in the public system, the importance of building an institutional network for patient support, the role of each and 2015. member of the healthcare team and the current state of access to medications in Uruguay.

150 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 151 Employees

Roche Uruguay currently employs 117 people, 49% of whom are Training: women and 51% men. It is our belief that diversity and inclusion are a competitive advantage for our company and we work to en- Roche Uruguay trains all employees at its distribution fa- sure all Roche employees understand and embody our commit- cility in Paraguay on key topics including the Supplier ment. We provide our employees with benefits that include com- Code of Conduct, fair competition and anti-trust, ethics, prehensive health and life insurance, paid time off for marriage, professional behaviour and government relations, as well family member illness or bereavement, maternity and paternity as in interactions with healthcare professionals, healthcare leave, flex-time and summer Fridays (with early leave) and access organisations and related entities, to ensure Roche’s high to an on-site infirmary. standards are followed. In 2014 and 2015 Roche Uruguay conducted a review of the Supplier Code of Conduct to en- A sampling of our employee initiatives includes: sure it properly addresses current issues such as audits and ethics. • An annual wellness event to foster a culture of health and well-being among all employees that features a variety of ac- An intensive six-week change management course was tivities related to healthy lifestyle practices, preventative care, also offered for senior management to improve leadership emotional well-being and education in addition to the benefits skills. All members of the leadership team participated in available to Roche employees. the course and they each created individual development plans to guide progress going forward. • A Town Hall event for all employees featuring training videos and live testimonials from Roche employees from all over the world. The conversation covered the benefits of a diverse and inclusive workplace and how diversity contributes to innovation and competitive advantage.

152 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 153 Governance Communities

The Group’s guidelines on Corporate Governance are followed by Roche Uruguay allocates its community investments to create so- regional companies in Latin America and by extension, Roche cial value in three main areas: childhood, education and the local Uruguay; these guidelines include global policies and standards, community. Initiatives in 2014 and 2015 focused primarily on such as the Code of Conduct, which sets the mandatory be- community development and the environment. Through these haviour requirements for all activities. programmes Roche collaborated with different non-profit organisations, including Repapel, Cippus, Paulina Luisi Home and the Roche Uruguay ensures all employees and suppliers attend rel- Forge Foundation to support the increased use of recycled paper, evant classroom trainings and complete all required e-learning develop youth scholarship opportunities and provide technology modules. Employees participate in mandatory e-learning train- donations benefitting a total of 290 individuals. ings on ethics, compliance and sustainability topics. Roche Uru- guay also provided six classroom trainings on our Directive on Recognising a need for more technology in a local public high Grants, Sponsorships and Donations (GSDs), data privacy and school, Roche worked with the lyceum Impulse to donate com- social media, amongst other topics. puters and monitors through an internal company auction. The technology enabled students to showcase their artistic skills and Roche community initiatives in 2014 and Because our suppliers are an important part of our business, enter their work in a competition abroad. Roche Uruguay conducted five supplier audits in 2014 and 2015. 2015 benefited a total of 290 individuals. During this time, Roche also organised a Supplier Day where all major suppliers were trained on the Supplier Code of Conduct, and performed an additional quality and compliance visit to a storage supplier in 2015.

154 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 155 Watch video here Venezuela

I am an administrator by profession, and worked in the private “By joining forces, we sector for over 15 years. But something happened that made me change my course, something that allowed me to identify the can help patients in a mission that I will pursue for the rest of my life. meaningful way.” At the end of 2003, I was diagnosed with non-Hodgkin lymphoma. At the moment, I was overtaken by sadness and fear, as it is Alexis Perez Laya terrible to face a situation in which you really do not know what Executive President of the Venezuelan Association will happen. But soon I internalized my condition, and began a of Friends with Lymphoma (AVAL) Environment combined treatment with chemotherapy and immunotherapy. Fortunately, at the end of the fifth treatment cycle, there was a full Roche Uruguay continues to pursue and develop energy-saving remission of the disease. I was cured. policies that optimise resource use and efficiency. We followed this approach while building new Montevideo headquarters, After this life-changing experience, I wanted to help other lym- That is why I believe that beyond the innovative medicines that which opened in November 2014 and received the Silver Certi- phoma patients cope with the disease, so I started working for change the fate of many people like me, companies like Roche fication in Sustainable Design under LEED®’s Commercial Inte- AVAL. And there, I realized how important it is for patient organ- can make a very valuable contribution to society by supporting riors category. The building’s design maximised natural lighting isations to receive support themselves. This support can happen patient organisations and programmes. and also included LED lamps and an air conditioning systems in many ways. For instance, I recently had the opportunity to par- that offers individualised temperature controls. The full span of ticipate in the training programme “The Voice of the Patient in building details – from its interior design to the exact building Action.” The initiative provided me, as a representative of AVAL, location – were considered from an environmental standpoint. with knowledge and skills to have an active role in public health The location itself is in an area of the city that is easily reached by policy, and in that way be able to better advocate for patients. public transportation, bicycle, car or foot.

156 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 157 Roche Venezuela at a Glance Caracas 1961 Headquarters Established

Women in Headcount Women Key Positions Turn Over Rate 263 64.6% 65% 16.6% 2014 2014 2014 2014 152 67.1% 75% 68.3% 2015 2015 2015 2015

Total Hours Hours of Training New Hires Internal Hires of Training per Employee 59 9 3,253 12.4 2014 2014 2014 2014 36 13 4,607 30.3 2015 2015 2015 2015

Clinical Trials 2014 2015 Research & Development 2014 2015

Number of Clinical Studies 10 8 Investment in R&D (mCHF)(45) 11 6

Number of Active Sites 24 19 Number of Employees in R&D 56 30 Healthcare in Venezuela Roche in Venezuela

(45) Million Swiss francs Number of Patients 50 58 Of Venezuela’s 30 million inhabitants, a considerable percentage With administrative headquarters in Caracas, Roche has been in Clinical Trials suffer from conditions caused by cancer, multiple sclerosis, viral operating in Venezuela since 1961. Roche Venezuela current- hepatitis and rheumatoid arthritis, among other diseases. The ly serves the country’s public and private healthcare markets cancer rate alone has been increasing annually and it is estimated and is organised into three divisions: Pharma, Diagnostics and Environment 2014 2015 that more than 58,000 Venezuelans will suffer from some type of Diabetes Care. Pharma has two business units: Oncology, Hae- cancer by the year 2020. matology and Anaemia, as well as Rheumatoid Arthritis and Energy Consumption (GJ) 3,411 4,199 Special Products. To help address this challenge, the Venezuelan Social Security Institute (IVSS) has created the “High Cost Pharmacies” system, In 2014 Roche Venezuela increased the reach of its patient ac- GHG Emissions (tons) 242 124 which guarantees treatment for serious and chronic diseases. The cess programmes and added two products whose costs to patients IVSS currently serves 88% of the country through the public sec- could be covered by Social Security. A struggling economy in Water Consumption (cubic meters) n/a n/a tor and another 2% of the population receives their medicines 2015 contributed to a reduced portfolio and exacerbated health- through the Badan Foundation, a pharmacy that specialises in care access barriers in the country’s public sector. Despite exter- high cost medicines and provides patient support. The remaining nal circumstances, Roche continued to provide core treatments General Waste Produced (tons) n/a n/a 10% of the population lives in rural areas that do not have health- through Social Security to ensure patient access. care infrastructure in place. Recycling (tons) 1,304 2 The IVSS is a key driver for continually improving healthcare services and access to products for the people of Venezuela. It oper- Paper Consumption (tons) 1,304 2 ates under the directive of “guaranteeing and protecting the rights and full service of the entire population.” However, changes in the Investment in SHE (CHF)(46) 32,000 n/a local economy can significantly impact the level of support that (Safety, Security, Health and Environment) this programme is able to provide. (46) Investment ﬁgures in Swiss francs and also include the Diagnostics Division

158 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 159 Sustainability Initiatives Access to Healthcare

To support the Group’s goal of helping patients access the benefits of complete and innovative treatments with quality medicines, Roche Venezuela focuses local activities around five pillars: De- livering Innovation, Increasing Disease Awareness, Strengthen- ing Healthcare Infrastructure, Improving Affordability and Sup- porting Local Patient Organisations.

In order to overcome barriers to access within the public healthcare system, Roche pursued innovative approaches to maintain sustainability, support patient organisations beyond financial contributions and increase disease awareness.

Delivering Innovation

Through Roche Venezuela’s work to create and develop medications and diagnostics that meet people’s health needs and substantially improve their quality of life, Roche makes generous industry contributions to advancing research.

Throughout 2014 and 2015, Roche Venezuela drove 18 clinical studies across 43 sites, reaching a total of 108 patients with a heavy focus on oncology. Roche also invested 17 million CHF(47) in research and development during this two year period to advance medicine and healthcare.

Throughout 2014 and 2015, Roche In 2014 Roche Venezuela conducted an internal contest that encouraged employees to develop an innovative idea. A total of Venezuela drove 18 clinical studies eight teams advanced to the final stage, and the winning team received an “I Innovate” award for developing a new employee across 43 sites with 108 patients. manual, which includes information about the global company and specifically Venezuela´s affiliate. The manual also provides directives around work activities to empower employees toward a successful future.

(47) Swiss francs

160 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 161 Roche Venezuela supports and drives awareness for many health related Increasing Disease Awareness campaigns.

A patient’s well-being goes beyond proper diagnosis and treatment, and should include raising awareness and support for health. Roche Venezuela supports and drives awareness for many health related campaigns to help patients prevent disease, receive early diagnoses and acquire the proper treatment they need in a timely manner. Some of the awareness initiatives active in 2014-2015 included:

• The “Pink Network,” a website for patients that offers infor- • “Gaining Life, Living the Disease Collectively” is a project that mation about 12 breast cancer organisations. Roche Venezuela supports the promotion and development of patients’ well-be- supported the website development and also held a compre- ing. The initiative’s leadership programme helps patients de- hensive training for patients and caregivers about breast can- velop and maintain a positive attitude, allowing them to see cer and the impact it has on women’s lives. Additionally, we new opportunities for life. Specifically during 2014- 2015, the led a conference on “Sexuality in Women with Mastectomy” project supported the creation of new patient organisations for the benefit of the general public, and organised the “HER2 for rheumatism, as well as colon and ovarian cancers, helping Innovation Symposium: Improving Metastatic Breast Cancer nearly 50 patients. Patients’ Survival” for physicians. • “A Breath for More Life” aims to raise awareness and educate • The “ESTAR” programme raises awareness around health is- elementary and high school students on how smoking habits sues and treatment options for people diagnosed with cancer are linked to cardiovascular and cancer disease risk, including or rheumatoid arthritis. Roche’s partnership with private and lung cancer and other respiratory conditions. In 2015 a total of public hospitals, as well as laboratories, provides support to six lectures were held in public and private schools in Caracas, patients through solutions adjusted to their circumstances, benefitting 432 children. offering guidance on side effects and how to live a healthier life, and other tips for enhancing well-being. Over the past 10 In 2014 and 2015 Roche Venezuela also drove awareness initia- years, 16,953 patients have benefitted from the programme tives around public campaigns for the following diseases: diabe- and currently, there are 6,628 active participants. tes, rheumatoid arthritis, lymphoma, melanoma, as well as colorectal, breast, ovarian and lung cancers.

162 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 163 Supporting Local Patient Organisations

In addition to hosting its own initiatives, Roche Venezuela also provides support to local patient organisations. Throughout 2014 and 2015, Roche Venezuela worked with a number of organisations including: the Venezuelan Association of Friends with Lym- phoma, SenosAyuda, the Venezuelan Association of Parents of Children with Cancer, Quality of Life Foundation, Cancer Soci- ety of Venezuela, Falcon Foundation, the association Friends of the Transplanted, I Rheumatism, the Venezuelan Association for Haemophilia, the Friends of Women with Breast Cancer Foun- dation, Fundaseno, Asosevid, Isabel Rivas Foundation, MELT, FundaVida, Fundaquimio, SenosEsperanza and Friends United for a Healthy Liver.

Examples of collaborative initiatives include:

• Support for the launch of the colorectal cancer patient association ColonSalud, a non-profit organisation dedicated to educating, promoting and guiding people with colorectal cancer. The organisation helps improve well-being and quality of life by disseminating updated information on the disease and providing emotional support for patients and their families. Roche also helped to organise informative discussions around nutrition on behalf of the “ESTAR” programme, reaching 150 patients and 70 physicians.

• Assistance in the launch of Infovario, a patient support organisation that provides information to women with ovarian cancer and their families. The organisation also provides information on where specialised medical care and treatments are available. In 2015 the programme reached 150 patients.

• Aid in the launch of the organisation I Rheumatic, which seeks to foster the early diagnosis for diseases related to bones, mus- cles, joints and other tissues. Strengthening Healthcare Infrastructure Improving Affordability

Recognising that barriers to proper care often include issues • Roche helped to create a series of workshops and brainstorms Roche adapts its healthcare strategy to meet the greatest needs with basic infrastructure, access to medical education and lack of to discuss issues including monoclonal antibodies, proteomics in the markets where we operate. Affordable products and diag- training, Roche Venezuela participates in strategic meetings with and molecular biology across three different hospitals. In 2015 nostics are in high demand within Venezuela, and as such are an Roche Venezuela participates local health authorities to break down healthcare barriers. Roche sixty-nine doctors and 32 nurses from different specialties area that Roche aims to advance. works with healthcare programmes to formulate new guidelines participated and later sought more information about mono- in strategic meetings with for health management, train healthcare professionals and pro- clonal antibodies as well as the new cancer therapies that were A sample of the initiatives conducted by Roche Venezuela in vide donations to infusion rooms at public hospitals. discovered based on these developments. 2014 and 2015 to improve affordability include: local health authorities Sample initiatives that sought to remove healthcare barriers and • “Integrated Healthcare Solutions”: a programme that offers to break down healthcare strengthen infrastructure and medical education included: additional support for breast cancer patients to access diagnostic tests. barriers. • “Oncology Dossier” is a project that facilitates information sharing among oncologists through a journal created by • Roche Venezuela also conducts multiproduct negotiations Roche’s Medical Affairs team. The dossier provides real clin- with the IVSS for all high-cost medicines, offering a compre- ical cases and other scientific information and emphasises the hensive package with exclusive and non-exclusive products in correct use of Roche products in all their indications accord- the areas of oncology, haematology, viral infections and rheu- ing to their local label. matoid arthritis.

164 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 165 Employees Governance

Roche Venezuela currently employs 152 individuals, of which Governed by the Group’s Business Code of Conduct policy and 33% are men and 67% are women, with 12 women currently in the Roche Code of Ethics, Roche Venezuela upholds integrity and key leadership positions. In 2015 the Great Place to Work® Insti- ethics in all settings, internally and externally. tute ranked Roche as the only pharmaceutical company in the top 20 companies to work for in Venezuela. Employee benefits Roche Venezuela also maintains close relations with local institu- include a wide range of initiatives such as free sports classes, tions in the healthcare field through membership in the following well-being activities and employee development opportunities. A establishments: few highlights from our employee benefits programmes include: • Venezuelan Chamber of Medications (Caveme) • “Roche in Positive,” a project that offers employees tools to live • Swiss Chamber a more satisfying and fulfilling life while promoting Roche’s • Venezuelan-German Chamber (Cavenal) values of integrity, passion and courage, which lead in turn • Industrial and Commercial Association of Los Cortijos and to a better work environment. The programme aims to pro- Los Ruices (Asicor) mote creativity, emotional intelligence, positivity, generosity • National Federation of Labour Unions for Workers in Medici- (in terms of employee volunteer opportunities) and happiness nal, Cosmetic and Perfume Products (Fetrameco) among all Roche Venezuela employees. This helps foster a greater sense of belonging in the company and positive impact on employees in their daily work. A survey in June 2014 Communities showed that 68% of employees believed that “Roche in Posi- tive” had positively influenced their lives. As a member of each community where Roche is located, we believe that an investment in the local area is necessary to create • “Diversity and Inclusion Week: Imagine Tomorrow Starting societal value. Roche Venezuela is currently creating an employee Today,” which offers weeklong activities to raise awareness volunteer group that can provide local support for programmes about diversity and inclusion as well as its importance and val- helping children, education and community activities. ue to Roche’s culture. In 2015 Roche Venezuela employees donated 32 hours of their • “Referral programme 2015,” a communications campaign time through two main events: promoting recruitment through employee recognition for referrals. A slogan contest for the name of the campaign en- • Twenty five Roche employees visited paediatric cancer pa- couraged additional employee engagement and generated a tients at FUNDANA and the Friends of Children with Can- positive response from employees. cer Foundation.

• Roche employees participated in Roche’s global Children’s Walk, raising $153.200 BS(48) for Malawi’s children and the Friends of Children with Cancer Foundation.

(48) Venezuelan bolivar

166 Roche Latin America 2014-2015 Sustainability Report Roche Latin America 2014-2015 Sustainability Report 167 Environment

Roche Venezuela strives to reduce the indirect environmental im- • “Disposal of Dangerous Wastes” hires the services of a special- pact of its activities through energy-saving policies, optimising ised handler of dangerous waste, authorised by the Ministry of resource use and dedicated work in the areas of safety, health and Environment, which issues a certificate of proper disposal of protection of the environment. Roche has developed multiple the material. campaigns supporting this initiative, including: • “Plan of Energy Saving” was formalised in 2014 with COR- • “Programme for Recycling Paper and Cardboard” collects a POELEC, the national energy savings plan to drive awareness variety of materials that are then recycled by Repaveca. for domestic energy saving.

• “To the Last Bullet” works with FUNDANA to recycle used • A tree planting activity, developed as part of our World Lung toners every two months. Cancer Day campaign, helped to reforest a 750 m2 reserve at Simon Bolivar University with 75 new trees. Approximately 50 employees participated in the activity and the event helped to strengthen and protect Caracas’ natural resources.

168 Roche Latin America 2014-2015 Sustainability Report

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