Product Data Sheet Inhibitors
Galidesivir triphosphate • Agonists
Cat. No.: HY-133331
CAS No.: 1467740-78-8
Molecular Formula: C₁₁H₁₈N₅O₁₂P₃ • Screening Libraries Molecular Weight: 505.21
Target: DNA/RNA Synthesis
Pathway: Cell Cycle/DNA Damage
Storage: Please store the product under the recommended conditions in the COA.
BIOLOGICAL ACTIVITY
Description Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2].
In Vitro In virus-infected cells, Galidesivir is converted to the triphosphate, is incorporated into the viral transcript, and functions as an atypical chain-terminator for RNA-dependent RNA polymerases. Galidesivir is converted to the mono- , di-, and triphosphates in virus-infected human Huh-7 cells[1]. Galidesivir triphosphate (Immucillin-A triphosphate) (1-60 μM) inhibits hepatitis C virus (HCV) RNA polymerase transcriptional activity in a cell-free, isolated enzyme transcription assay.The triphosphate is a substrate for viral RNA- dependent RNA polymerase. Its incorporation permits the addition of a few additional encoded bases at which point the Galidesivir-modified RNA cannot be elongated[2].
In Vivo In vivo conversion of Galidesivir to its TP (Galidesivir triphosphate) nucleotide is particularly efficient[3]
REFERENCES
[1]. Evans GB, et al. Immucillins in Infectious Diseases. ACS Infect Dis. 2018 Feb 9;4(2):107-117.
[2]. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014 Apr 17;508(7496):402-5.
[3]. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016 May-Jun;9(3):220-6.
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Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
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