(12) Patent Application Publication (10) Pub. No.: US 2002/0128522 A1 Te0doro Et Al
US 2002O128522A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2002/0128522 A1 Te0doro et al. (43) Pub. Date: Sep. 12, 2002 (54) PROCESS FOR THE PREPARATION OF 4.4 (30) Foreign Application Priority Data -DHALOGEN-O-HYDROXYDIPHENYL COMPOUNDS Oct. 6, 1998 (EP)........................................ 988 11 OO2.9 Publication Classification (76) Inventors: Armando Di Teodoro, Rheinfelden (51) Int. Cl." ..................................................... C07C 43/20 (DE); Werner Holzl, Eschentzwiller (52) U.S. Cl. .............................................................. 568/637 (FR); Dieter Reinehr, Kandern (DE); Rudolf Zink, Therwil (CH) (57) ABSTRACT Disclosed is a four-step proceSS for the preparation of Correspondence Address: 4,4'-dihalogen-O-hydroxydiphenyl compounds of formula CBA SPECIALTY CHEMICALS CORPORATION (1) PATENT DEPARTMENT OH 540 WHITE PLAINS RD PO BOX 2005 TARRYTOWN, NY 10591-9005 (US) Hal Hall, (21) Appl. No.: 10/137,791 (22) Filed: May 2, 2002 by halogenation of a diphenyl compound (step 1a) or by the reaction of p-halophenol and p-dihalobenzene (step 1b), Related U.S. Application Data acylation of the dihalogen compound in a Friedel-Crafts (63) Continuation of application No. 09/806,359, filed on reaction (2"step), oxidation of the acyl compound (3"step) Mar. 29, 2001, now abandoned, filed as 371 of and hydrolysis (4" step). international application No. PCT/EP99/07158, filed The compounds of formula (1) are used for protecting on Sep. 27, 1999. organic materials and objects from microorganisms. US 2002/O128522 A1 Sep. 12, 2002 PROCESS FOR THE PREPARATION OF 4.4 -DHALOGEN-O-HYDROXYDIPHENYL -continued COMPOUNDS 0001. The present invention relates to a process for the OH preparation of 4,4'-dihalogen-O-hydroxy-diphenyl com pounds of formula (1) OH Cl C O (3) Hal Hall, 0006) However, the yield obtained by this method of 0002 wherein preparation is unsatisfactory as different chemical reactions 0003 Hal is a halogen atom, may take place concurrently.
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