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Programme and Abstract Official programme & abstracts for the Joint 11th International and 9th European Symposium on Purines and Pyrimidines in Man (PP’03) 9-13 June 2003 Hotel Zuiderduin, Egmond aan Zee, the Netherlands Editor-in-chief: Prof. Dr. G.J. Peters Published by: Drukkerij Peters in alliance with VU University Medical Center, Amsterdam, the Netherlands May 2003 2 Contents Welcome 4 Organising committee 5 Contact addresses 6 Support 7 Young Investigator Award 7 Registration fee 8 Venue Hotel Zuiderduin 8 Plan Hotel Zuiderduin floor 0 9 Plan Hotel Zuiderduin floor 1 10 Programme PP’03 11 Invited presentations (I01 – I24) 22 Oral presentations (O01 – 046) 50 Poster presentations (P01 – P95) 92 Author index 189 Overview International and European Symposia on Purine and Pyrimidine Metabolism 192 3 Welcome to the Netherlands This series of congresses on Purine and Pyrimidine metabolism started 30 years ago in Tel Aviv and has since then moved around the world. It is now coming back to places which have been visited before. Three years ago the meeting was in Tel Aviv for the second time. The meeting has also been held twice in Austria. You can find an overview of the meetings on the last page of this abstract book. Twenty-one years ago the meeting was held in the most southern part of the Netherlands, Maastricht. Now we welcome the international meeting for the 2nd time in the Netherlands but at the other site with an excellent view on the sea. Usually the weather conditions permit to go to the beach. Alternatively you can take a walk through the dunes during the afternoon break. The meeting is planned in such a way that you have some time off after the lunch, enabling to relax or to prepare for the poster sessions. For these poster sessions we will try a novel concept. Each poster presenter will have a few minutes to highlight the most important points of his/her research to encourage everybody to come and take a look at the posters, which are located close to the lecture hall. To compensate for this we continue in the evening with two exciting sessions. In the methods sessions we are very pleased that we can give you an up to date overview of analytical and molecular biological techniques. We were encouraged to organize a special Lesch-Nyhan syndrome session, because molecular biology has provided some new insights in this disease. The meeting again provides an excellent environment for translational research. For that purpose we have a session called from “Bench to the Clinic” which is intended to give you some insight, both from a company and an investigator point of view, how drugs proceed from the test tube to the patient. These meetings on Purine and Pyrimidine metabolism always provided an excellent forum for so-called horizontal translational research: from one specialty to the other. In the past we had excellent examples, e.g. from immune deficiency to cancer, now we have examples from rheumatology to cancer to cardiology and vice versa. These interactions have made this series of meetings a success in the past and will do similarly in the future. This will be the task of a new generation. Many of the original participants and organizers retired or are retiring and a new generation is taking over, which has the challenge to keep this meeting as exciting as ever in a much more competing field. I attended the first meeting as a Ph.D. student and made friendships with others who are also here as senior investigators. Our current Ph.D. students should be enabled to proceed similarly. However, they have many other challenges outside and inside the field. For the last reason we should keep in close contact with others working on nucleosides and nucleotides, Therefore we decided to publish the proceedings in Nucleosides, Nucleotides & Nucleic Acids. This meeting would not have been possible without the help of much support. First I have to thank my collaborators in the oncology laboratory, other colleagues at the VU University Medical Center, my colleagues from the national organizing committee for their support in planning, and the members of the scientific committee who suggested sessions and speakers and reviewed the abstracts timely enabling us to make an objective selection of the abstracts. The excellent support of the conference office was instrumental in enabling this electronic review and all other logistics. They will be around for any question you may have. As you noticed we did not do any paper announcement and proceeded entirely electronically. The generous support of the various sponsors is greatly appreciated. Without their support it would not have been possible to keep the costs of the meeting within limits. Finally I regret that several colleagues from the Far East (Taiwan, China, Japan) are not able or allowed to travel because of circumstances outside their control, such as SARS, and I sincerely hope that a next time they will be able to attend. I wish everybody a successful meeting Prof. Dr. Godefridus J. Peters 4 Organising Committee Local organising committee: Board of the ESSPPMM: G.J. Peters, Amsterdam, chairman G.J. Peters (NL) President R.A. De Abreu, Nijmegen I. Sebesta (CZ) Vice-President J.W. De Jong, Rotterdam G. Van den Berghe (B) Past-President A.B.P. Van Kuilenburg, Amsterdam A.C. Skladanowski (PL) Secretary A.P. IJzerman, Leiden A. Griesmacher (A) Treasurer International Scientific Committee: ESSPPMM Scientific Committee: J. Balzarini, Belgium J. Balzarini, Leuven J. Barankiewicz, USA E.A. Carrey, London M.A. Becker, USA R.A. De Abreu, Nijmegen R.I. Christopherson, Australia S. Eriksson, Uppsala R.A. De Abreu, The Netherlands A. Giacomello, Rome R.B. Diasio, USA M.L. Löffler, Marburg S. Eriksson, Sweden W. Makarewicz, Gdansk M. Fukushima, Japan E. Marinello, Siena V. Gandhi, USA V. Micheli, Siena N. Kamatani, Japan B. Munch-Petersen, Roskilde M. Müller, Austria M.M. Müller, Vienna D. Perrett, UK G.J. Peters, Amsterdam G.J. Peters, The Netherlands J.D. Puig, Madrid R.L. Sabina, USA I. Sebesta, Prague I. Sebesta, Czech Republic H.A. Simmonds, London -Honorary Member H.A. Simmonds, UK A.C. Skladanowski, Gdansk A.C. Skladanowski, Poland R.T. Smolenski, Harefield - Gdansk R. Smolenski, Poland O. Sperling, Tel Aviv F.F. Snyder, Canada M. Staub, Budapest O. Sperling, Israel G. Van den Berghe, Brussels M. Staub, Hungary N. Zöllner, Munich - Honorary Member L.F. Thompson, USA G. Van den Berghe, Belgium A.B.P. Van Kuilenburg, The Netherlands G. Weber, USA 5 Contact Addresses Scientific programme Prof. Dr. G.J. Peters Dept. Medical Oncology VU University Medical Center Address: De Boelelaan 1117 1081 HV Amsterdam The Netherlands Phone: +31 20 444 2633 Fax: +31 20 444 3844 E-mail: [email protected] Symposium secretariat Ms. S. van Geloven Dept. Medical Oncology BR232 VU University Medical Center Address: De Boelelaan 1117 1081 HV Amsterdam The Netherlands Phone: +31 20 4442630 Fax: +31 20 4443844 [email protected] E-mail: [email protected] Registration and logistics PAOG Course and Congress Organisation VU University Medical Center MF/D-237 Address: Van der Boechorststraat 7 1081 BT Amsterdam The Netherlands Phone: +31 (0)20 444 8444 Fax: +31 (0)20 444 8445 E-mail: [email protected] 6 Support We would like to thank the following companies/institutes for their support: Main Sponsor Taiho Pharmaceutical Co., Ltd. www.taiho.co.jp/english/ Sponsors Applied Biosystems www.applera.com Eli Lilly & Company www.lilly.com Roche Diagnostics Nederland BV www.roche-diagnostics.com Royal Netherlands Academy of Arts and Sciences www.knaw.nl/english/index.html Sanofi-Synthélabo www.sanofi-synthelabo.com Shire BioChem Inc. www.shire.com Contributor Thermo Electron BV Young Investigator Award The Young Investigator Award has been awarded to: C. Carnrot, Uppsala, Sweden, Z. Horvath, Vienna, Austria, Z. Khalpey, Harefield, UK, S. Mani, Calgary, Canada, A. Yuen, Harefield, UK. The Young Investigator Award has been made possible by generous contributions from PP91 and ESSPPMM '93. 7 Registration fee The full symposium fee includes the following: • admission to all sessions • programme & abstract book • welcome drinks on Monday, June 9 • coffee and tea during breaks • lunch from Tuesday, June 10 to Friday, June 13 • dinner at Zuiderduin on Tuesday, June 10 & Wednesday, June 11 (including 1 drink and 1 coffee) • excursion to Enkhuizen & the Zuiderzee Museum on Wednesday afternoon, June 11 • barbecue at Grand Café Lido on Thursday evening, June 12 • symposium proceedings Venue Hotel Zuiderduin Hotel Zuiderduin is perfectly situated within hundred metres of the beach and the town centre of Egmond aan Zee. The symposium will be held at the 0-floor of the hotel (see floor plan on the next page). On Monday, June 9, you are all invited to come to the Van Speykzaal for the welcome reception at 18:00 hrs. From Tuesday, June 10, on all oral presentations will take place at the Zuiderduinzaal. The poster area is situated in the Foyer and the Le Regal room with are both adjacent to the Zuiderduinzaal. During the symposium, coffee and tea will be served in Le Regal, and lunch and dinners will take place at the Restaurant of Zuiderduin Hotel rooms All rooms are fully equipped with a colour television, telephone, alarm clock and bathroom. The room rates are including breakfast and taxes. Check-in is from 15:00 hrs and check-out before 10:30 hrs. Facilities The hotel is accommodated with a wide range of leisure facilities, including a heated indoor swimming pool and massage whirlpool (free of charge). For a service charge the following facilities are available: saunas, Turkish and Japanese baths, solarium, beauty parlour, hairdresser and squash courts.
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