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ADVANTAGE LEPTOSPIRA Igm & Igg CARD Rapid diagnostic test for the Qualitative detection of Leptospira specific IgM & IgG antibodies in human serum/ plasma One Step procedure, add sample & read Result Results within 20 minutes Bio-hazard free, fully covered, see-through Device Rapid, visual and qualitative immunoassay Shelf life 18 months at 2-30ºC Sensitivity: 99.22% Specificity: 99.61% Distinguish pathogenic Leptospira from other diseases Leptospira: an emerging disease Leptospirosis is a disease caused by infection with bacteria of the genus Leptospira that affects human as well as other mammals.Though recognised among the world’s most common diseases transmitted to people from animals, the infection is commonly transmitted to human by allowing water that has been contaminated by animal urine to come in contact with unhealed breaks in the skin, the eyes, or with the mucous membranes. Leptospirosis is a biphasic disease that begins with flu-like symptoms (fever, chills, myalgias, intense headache). The first phase resolves, and the patient is briefly asymptomatic until the second phase begins. This is characterized by meningitis, liver damage (causing jaundice), and renal failure. The infection is often wrongly diagnosed due to the wide range of symptoms. This leads to a lower registered number of cases than exists. Symptoms of leptospirosis include high fever, severe headache, chills, muscle aches, and vomiting, and may include jaundice, red eyes, abdominal pain, diarrhea, and rash. Initial presentation may resemble pneumonia. The symptoms in human appear after 2–20 days incubation period. Prototypic antibody response in Leptospirosis against time* Culture/PCR IgM Serology Microscopic Agglutination Test Most cases of leptospirosis are diagnosed by serology as:- Antibodies become detectable by 6th to 10th day of Spiraemic phase disease and generally reach peak levels within 3 to 4 Leptospira burden (blood) weeks. The incubation period of 2-20 days is followed by a Anti-leptospira IgM biphasic disease, with an acute spiraemic phase of Anti-leptospira IgG approximately 7 days followed by an immunogenic phase characterized by the production of IgM and later IgG Antibodies. serological response IgM Antibodies are detectable in sera within 6 to Organism burden (blood)/ 10 days after infection followed by IgG Antibodies. 5 10 15 20 Other tests like Culture/PCR are not an optimal tool to Time since infection (days) determine the initiation of management of disease due to 1-2 week delay in definitive diagnosis and the diagnosis Source : Australian Family Physician, Vol. 39, No. 7, July 2010, Pg.- 496 * varies based on infecting serovar of Leptospira. Test Procedure Result Interpretation t of the Manufacturer STEP-1 Add 3 drops (100 µl) of ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG C ADV. LEPTOSPIRA IgM & IgG C ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG CARD serum/ plasma sample C M G C M G . LEPTOSPIRA IgM & IgG CARDG using sample dropper ADV M C into the sample well Reactive for both leptospira Reactive for leptospira IgM antibodies IgM & IgG antibodies STEP-2 ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG CARD Allow reaction to occur ADV. LEPTOSPIRA IgM & IgG C ADV. LEPTOSPIRA IgM & IgG C ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG CARD during next 20 minutes C M G C M G . LEPTOSPIRA IgM & IgG CARDG ADV M C and READ RESULTS Reactive for leptospira IgG antibodies Non-Reactive for leptospira antibodies PRODUCT ADV. LEPTOSPIRA IgM & IgG CARD ADV. LEPTOSPIRA IgM & IgG C ADV. LEPTOSPIRA IgM & IgG CARD VIDEO DEMONSTRATION C M G Http://www.youtube.com/watch?v =4Pap1zYyPcg&list= Invalid Test & re-run the test UUwxCAIzNi_vMPC74_ NUT40g&index= 1&feature=plcp Log on For further enquiries, Please contact: J. Mitra & Co. Pvt. Ltd. A 180-181, Okhla Indl. Area, Phase-1, New Delhi - 110 020, INDIA ISO 13485:2016 Tel: +91-11-47130300, 500, 26818971-73 ISO 9001:2015 Pack size Available: ICMED 13485 E-mail: [email protected] Website : www.jmitra.co.in 10 & 25 Tests BR/ALC/010 R-03 Specifications/ Designs are subjected to change without any obligation on the par.
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