GPCR Expression in Cancer Cells and Tumors Identifies New
fphar-09-00431 May 17, 2018 Time: 16:38 # 1 ORIGINAL RESEARCH published: 22 May 2018 doi: 10.3389/fphar.2018.00431 GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets Paul A. Insel1,2*†, Krishna Sriram1†, Shu Z. Wiley1, Andrea Wilderman1, Trishna Katakia1, Thalia McCann1, Hiroshi Yokouchi1, Lingzhi Zhang1, Ross Corriden1, Dongling Liu1, Michael E. Feigin3, Randall P. French4,5, Andrew M. Lowy4,5 and Fiona Murray1,2,6† 1 Department of Pharmacology, University of California, San Diego, San Diego, CA, United States, 2 Department of Medicine, University of California, San Diego, San Diego, CA, United States, 3 Department of Pharmacology and Therapeutics, Roswell Edited by: Park Comprehensive Cancer Center, Buffalo, NY, United States, 4 Department of Surgery, University of California, San Diego, Ramaswamy Krishnan, San Diego, CA, United States, 5 Moores Cancer Center, University of California, San Diego, San Diego, CA, United States, Harvard Medical School, 6 School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom United States Reviewed by: G protein-coupled receptors (GPCRs), the largest family of targets for approved drugs, Kevin D. G. Pfleger, Harry Perkins Institute of Medical are rarely targeted for cancer treatment, except for certain endocrine and hormone- Research, Australia responsive tumors. Limited knowledge regarding GPCR expression in cancer cells likely Deepak A. Deshpande, has contributed to this lack of use of GPCR-targeted drugs as cancer therapeutics. Thomas Jefferson University, United States We thus undertook GPCRomic studies to define the expression of endoGPCRs *Correspondence: (which respond to endogenous molecules such as hormones, neurotransmitters and Paul A.
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