DOCSLIB.ORG

Aars Hot Topics Member Newsletter

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Aars Hot Topics Member Newsletter AARS HOT TOPICS MEMBER NEWSLETTER American Acne and Rosacea Society 201 Claremont Avenue • Montclair, NJ 07042 (888) 744-DERM (3376) • [email protected] www.acneandrosacea.org Like Our YouTube Page Visit acneandrosacea.org to Become an AARS Member and TABLE OF CONTENTS Donate Now on acneandrosacea.org/donate Industry News Mederma survey: America's got skin insecurities. ...................................................... 2 Our Officers Accure Acne seeks to raise up to $20 million through private placement offering ..... 2 J. Mark Jackson, MD AARS President New Medical Research Scientifically speaking: New directions in acne management, part 1. ........................ 3 Andrea Zaenglein, MD Tranexamic acid microinjections ................................................................................. 3 AARS President-Elect An increase in normetanephrine in hair follicles of acne lesions ................................ 4 Effects of ısotretinoin on the growth rate and thickness of the nail plate .................... 4 Joshua Zeichner, MD The effectiveness of botulinum toxin type A (BTX-A) in the treatment of facial skin .. 4 AARS Treasurer Efficacy and safety of non-surgical short-wave radiofrequency treatment ................. 5 Incidence and clinical implications of autoimmune thyroiditis ..................................... 5 Bethanee Schlosser, MD Topical 15% resorcinol is associated with high treatment satisfaction ....................... 6 AARS Secretary A novel azelaic acid formulation for the topical treatment of inflammatory rosacea ... 6 The effectiveness of galactomyces ferment filtrate ..................................................... 6 James Del Rosso, DO Director Clinical Reviews Emmy Graber, MD Efficacy of non-surgical monotherapies for hidradenitis suppurativa ......................... 7 Director Treatment challenges in adult female acne and future directions .............................. 7 Adalimumab induces a wound healing profile in patients ........................................... 8 Jonathan Weiss, MD Self-limited acne agminate-like granulomatous reaction ............................................ 8 Director Advances in oral isotretinoin therapy .......................................................................... 8 Boosting adherence and results with energy-based devices. .................................... 9 Stacey Moore Unraveling the heterogeneity of hidradenitis suppurativa with phenotype schema .... 9 Executive Director Use of botulinum toxin in treating rosacea .................................................................. 9 [email protected] Remote consultations for patients with hidradenitis suppurativa .............................. 10 Page 2 Industry News Mederma survey: America's got skin insecurities. Practical Dermatology, May 6, 2021. https://practicaldermatology.com/news/mederma-survey-skin-insecurities-have-major-impact-on-mental- health?c4src=search%3Afeed&utm_campaign=Practical%20Dermatology%20- %20Enewsletters&utm_medium=email&_hsmi=126575723&_hsenc=p2ANqtz- 8IAvXUSrlnzKcQ4zgwxFOz0UnD8WODhxK3G0DJzD1aAIFQdhDLtUx34IYfRNAYhwfMU7nJ0b9N8olOlj3PuTxRYy X2j5Vae4sfZPFQBJJkiS6O9mk&utm_content=126575723&utm_source=hs_email May is Mental Health Awareness month, and Mederma is unveiling their new "You Are More Than Your Scar" campaign to help people overcome skin insecurities and boost self esteem. One-third of Americans would not use their smart phone for a year if it meant they could have picture-perfect skin, according to a new survey from Mederma. That’s not all they would do for clear skin either, many would cancel Netflix for life eat only oatmeal for a year, give up their favorite food for life or skip sex for a year, the survey found. More than half of Americans avoid events altogether (pre-pandemic) instead of going through the hassle of dealing with skin issues and insecurities, and three in five respondents agreed that their skin has a big impact on their self-confidence and mental health. May is Mental Health Awareness month, and Mederma is unveiling their new "You Are More Than Your Scar" campaign to help people overcome skin insecurities and boost self esteem. Alongside the new campaign, Mederma has also unveiled new packaging design across their entire suite of products that is currently rolling out on shelves. "When we were creating our new 'You Are More Than Your Scar' campaign, it was inspiring to see that every scar has a story, and more importantly, people often fight silent battles with their marks and scars," says HRA Pharma America, President, Bradley Meeks, in a news release. "This survey has shown that skin insecurities affect everyone and feeling confident in the skin you're in has a connection to mental health." While the survey of 2,000 American adults revealed that skin imperfections have kept people from seeing family, going to birthday parties and even weddings, the survey also uncovered that some respondents already embrace their scars or have started to accept their insecurities – proving we are more than our scars. Download Reference Document Accure Acne seeks to raise up to $20 million through private placement offering. DermWire, Practical Dermatology, April 26, 2021. https://practicaldermatology.com/news/accure-acne-seeks-to-raise-up-to-20-million- through-private-placement-offering?c4src=topic%3Aacne%3Afeed&utm_campaign=Practical%20Dermatology%20- %20Enewsletters&utm_medium=email&_hsmi=126575723&_hsenc=p2ANqtz-89zUY2jvdCq6ReFH5b- VkRuRVE2eumJ_nJcx4Z80n66zZv8zWHdySHqTxNzYYBKiQt4JFiWgIyogEutA-aEpVD5_DE- LQfiXiPYF0PRGSkH7zKFFE&utm_content=126575723&utm_source=hs_email Accure Acne, Inc. has launched a private placement offering on the M-Vest platform to raise up to $20 Million. Building on the research of R. Rox Anderson, MD, Accure Co-Founder and Chief Scientific & Medical Officer, Accure has developed the Accure Laser System, an energy-based device that targets sebaceous glands. The company believes the technology utilizes a novel, proprietary treatment method that has been demonstrated on human tissue to damage sebaceous glands through selective photothermolysis, while sparing the surrounding epidermis from damage. In March 2020, Accure's exclusive manufacturing partner for the Accure Laser System, Quanta System S.p.A, received clearance for CE Mark certification. Accure believes this is the only 1726nm laser with CE Mark clearance for the treatment of moderate inflammatory acne. This investment involves a high degree of risk and should not be made by anyone who cannot afford to lose his or her entire investment. This investment is highly speculative and illiquid. The Subscription Agreement & Limited Liability Company Agreement is available online. American Acne & Rosacea Society (AARS) Hot Topics Volume: May 2021, Issue 1 Page 3 New Medical Research Scientifically speaking: New directions in acne management, part 1. Joel L. Cohen, MD; Diane Berson, MD; Linda Stein Gold, MD; and Emil Tanghetti, MD. Practical Dermatology, May 10, 2021. https://practicaldermatology.com/series/scientifically-speaking/scientifically-speaking-new-directions-in-acne- management-part-1?c4src=topic%3Aacne%3Afeed&utm_campaign=Practical%20Dermatology%20- %20Enewsletters&utm_medium=email&_hsmi=126575723&_hsenc=p2ANqtz-9DA9UTqsZgFsH7_v7Dsfzc-qQ- ZkHAoBg7u63JvkXbiSbb1gSlgy-_m-ZxR8f_6a45wptkSd3YM_rWs1hkfAo9lq- P8yY6xISZVmD2Up5pJ3p3T04&utm_content=126575723&utm_source=hs_email The recognition that inflammation is at the heart of acne has led to changes in management approaches and better understanding of how treatments work. In the first of a 2-part series, host Joel L. Cohen, MD talks to Diane Berson, MD; Linda Stein Gold, MD; and Emil Tanghetti, MD about acne approaches, with a focus on the latest in topical interventions. They address hot topics, including bacterial resistance and variations in treatment response across different patient populations. Tranexamic acid microinjections: A novel treatment option for erythematotelangiectatic rosacea. J Cosmet Dermatol. 2021 May 10. doi: 10.1111/jocd.14209. Online ahead of print. Daadaa N, Litaiem N, Karray M, et al. https://pubmed.ncbi.nlm.nih.gov/33973361/ Background: Treatment options for erythematotelangiectatic rosacea (ETR) are still scarce. Tranexamic acid (TXA) is an antifibrinolytic drug that was recently used for the treatment of ETR. Aims: to evaluate the efficacy and safety of intradermal microinjections of TXA for ETR. Patients/methods: This was a retrospective study enrolling patients, treated with TXA intradermal microinjections for ETR, from January 2019 to February 2020. Response to treatment was assessed based on subjective symptoms, clinical photographs and the Investigator Global Assessment of Rosacea Severity Score (IGA-RSS). Results: Six patients were included. The mean number of monthly intradermal TXA microinjections was 5.1±1.3. The mean decrease of IGA-RSS was 2.4±0.5. Local side effects, mainly transient erythema and swelling, were noticed in three cases. No systemic effects were noted. Clinical improvement, in respondent patients, lasted after 3 months of follow-up. Conclusion: Intradermal TXA microinjections is a safe and effective treatment option for ETR. The optimal number of monthly sessions has yet to be determined. American Acne & Rosacea Society (AARS) Hot Topics Volume: May 2021, Issue 1 Page 4 An increase in normetanephrine in hair follicles of acne lesions through the sympatho-adrenal medullary system in acne patients with anxiety. Mizuno K, Sakaue H, Kohsaka K, et al. J Dermatol.
Load more

Recommended publications
  • United States Atopic Dermatitis (AD) Market Report 2021
    Source: Research and Markets July 28, 2021 04:08 ET United States Atopic Dermatitis (AD) Market Report 2021 Dublin, July 28, 2021 (GLOBE NEWSWIRE) -- The "Atopic Dermatitis (AD) - US Market Insight, Epidemiology and Market Forecast - 2030" report has been added to ResearchAndMarkets.com's offering. This 'Atopic Dermatitis (AD) - Market Insights, Epidemiology and Market Forecast- 2030' report delivers an in- depth understanding of the Atopic Dermatitis (AD), historical and forecasted epidemiology as well as the Atopic Dermatitis (AD) market trends in the United States. Key Findings The total prevalent population of AD in the United States was estimated to be 32,197,083 in 2020. The total diagnosed prevalent population of AD in the United States was estimated to be 25,091,967 in 2020. The prevalent population of AD in the United States is expected to increase at a CAGR of 0.58% during the study period 2018-2030. In the United States, the total number of adult cases of AD comprised of 5,684,566 males and 9,421,907 females in 2020. The total number of cases of mild AD were 9,065,394 in the United States, in 2020, as compared to the cases of moderate and severe AD with 4,365,771 and 1,661,712 cases respectively, in adults. In children, the total number of cases of mild AD were 6,690,281, in 2020, as compared to the cases of moderate and severe AD with 2,596,228 and 698,985 cases respectively, in the United States. Report Highlights In the coming years, Atopic Dermatitis (AD) market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
    [Show full text]
  • Inflarx N.V. 2020 Dutch Board Report
    InflaRx N.V. Dutch statutory board report and financial statements for the financial year ended December 31, 2020 - 1 - TABLE OF CONTENTS 1 Introduction ............................................................................................................................... 4 1.1 Preparation ................................................................................................................................. 4 1.2 Forward-looking statements ...................................................................................................... 4 2* Risk factors ................................................................................................................................ 7 2.1 Summary of key risk factors ...................................................................................................... 7 2.2 Risk factors ................................................................................................................................ 7 2.2.1 Risks related to our financial position and need for additional capital. ..................................... 7 2.2.2 Risks related to the discovery, development and commercialization of our product candidates. ................................................................................................................................................... 9 2.2.3 Risks related to our dependence on third parties ..................................................................... 20 2.2.4 Risks related to our intellectual property ................................................................................
    [Show full text]
  • Conference Reportpeer-Reviewed
    Medicom International Conference Series in Dermatology 28th EADV Congress European Academy of Dermatology and Venereology 9-13 october 2019 • Madrid • Spain EVIEWED R PEER- CONFERENCE CONFERENCE REPORT Late-Breaking News Emerging Therapies Spotlight on Psoriasis JAK inhibitors are a fascinating The IL-4/IL-13 blocker dupilumab Ten-year data from the ESPRIT novel drug class entering the der- leads to rapid itch reduction in registry shows the importance of matologic arena. The JAK1 and adolescents. The safety profile is achieving good control of moderate- JAK2 inhibitor baricitinib showed similar to that in adults. to-severe psoriasis. to be effective in patients with moderate-to-severe atopic derma- titis in a phase 3 trial. read more on PAGE 5 read more on PAGE 10 read more on PAGE 13 Editor Peter van de Kerkhof, Radboud University Medical Center, the Netherlands MEDIC AL PUBLISHERS Contents Letter from the Editor 3 Late-Breaking News 3 IL-17A blocker effective in paediatric psoriasis patients 3 Rituximab beats mycophenolate mofetil in pemphigus vulgaris COLOPHON 4 Novel JAK1/2 inhibitor shows remarkable efficacy in alopecia areata Editor Prof. Peter van de Kerkhof Radboud University Medical Center, 5 Acne highly influenced by climate, pollutants, and unhealthy diet the Netherlands 5 JAK inhibition plus TCS lead to high clearance rates in AD Advisory Board Prof. Margarida Gonçalo 6 No cancer risk with long-term use of calcineurin inhibitor in Coimbra University Hospital, Portugal children with AD Dr Tom Hillary UZ Leuven, Belgium 7 Green
    [Show full text]
  • Atopic Dermatitis: an Expanding Therapeutic Pipeline for a Complex Disease
    REVIEWS Atopic dermatitis: an expanding therapeutic pipeline for a complex disease Thomas Bieber 1,2,3 Abstract | Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains challenging to treat owing to the limited response to available therapies. However, recent advances in understanding of disease mechanisms have led to the discovery of novel potential therapeutic targets and drug candidates. In addition to regulatory approval for the IL-4Ra inhibitor dupilumab, the anti- IL-13 inhibitor tralokinumab and the JAK1/2 inhibitor baricitinib in Europe, there are now more than 70 new compounds in development. This Review assesses the various strategies and novel agents currently being investigated for AD and highlights the potential for a precision medicine approach to enable prevention and more effective long-term control of this complex disease. Atopic disorders Atopic dermatitis (AD) is the most common chronic inhibitors tacrolimus and pimecrolimus and more 1,2 A group of disorders having in inflammatory skin disease . About 80% of disease cases recently the phosphodiesterase 4 (PDE4) inhibitor cris- common a genetic tendency to typically start in infancy or childhood, with the remain- aborole. For the more severe forms of AD, besides the develop IgE- mediated allergic der developing during adulthood. Whereas the point use of ultraviolet light, current therapeutic guidelines reactions. These are atopic dermatitis, food allergy, allergic prevalence in children varies from 2.7% to 20.1% across suggest ciclosporin A, methotrexate, azathioprine and 3,4 rhino- conjunctivitis and countries, it ranges from 2.1% to 4.9% in adults .
    [Show full text]
  • Frontiers in Dermatology and Venereology - a Series of Theme Issues in Relation to the 100-Year Anniversary of Actadv
    ISSN 0001-5555 ActaDV Volume 100 2020 Theme issue ADVANCES IN DERMATOLOGY AND VENEREOLOGY A Non-profit International Journal for Interdisciplinary Skin Research, Clinical and Experimental Dermatology and Sexually Transmitted Diseases Frontiers in Dermatology and Venereology - A series of theme issues in relation to the 100-year anniversary of ActaDV Official Journal of - European Society for Dermatology and Psychiatry Affiliated with - The International Forum for the Study of Itch Immediate Open Access Acta Dermato-Venereologica www.medicaljournals.se/adv ACTA DERMATO-VENEREOLOGICA The journal was founded in 1920 by Professor Johan Almkvist. Since 1969 ownership has been vested in the Society for Publication of Acta Dermato-Venereologica, a non-profit organization. Since 2006 the journal is published online, independently without a commercial publisher. (For further information please see the journal’s website https://www. medicaljournals.se/acta) ActaDV is a journal for clinical and experimental research in the field of dermatology and venereology and publishes high- quality papers in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as Correspondence to the Editor to stimulate debate. New books are also reviewed. The journal has rapid publication times. Editor-in-Chief: Olle Larkö, MD, PhD, Gothenburg Former Editors: Johan Almkvist 1920–1935 Deputy Editors: Sven Hellerström 1935–1969
    [Show full text]
  • Hidradenitis Suppurativa: Where We Are and Where We Are Going
    cells Review Hidradenitis Suppurativa: Where We Are and Where We Are Going Emanuele Scala 1,* , Sara Cacciapuoti 2 , Natalie Garzorz-Stark 1,3, Matteo Megna 2 , Claudio Marasca 2, Peter Seiringer 1,4, Thomas Volz 3, Kilian Eyerich 1,3,5,† and Gabriella Fabbrocini 2,† 1 Division of Dermatology and Venereology, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, 17176 Stockholm, Sweden; [email protected] (N.G.-S.); [email protected] (P.S.); [email protected] (K.E.) 2 Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy; [email protected] (S.C.); [email protected] (M.M.); [email protected] (C.M.); [email protected] (G.F.) 3 Department of Dermatology and Allergy, Technical University of Munich, 80802 Munich, Germany; [email protected] 4 Center for Allergy and Environment, Technical University, Helmholtz Center Munich, 80802 Munich, Germany 5 Unit of Dermatology, Department of Dermatology and Venereology, Karolinska University Hospital, 17176 Stockholm, Sweden * Correspondence: [email protected] † These authors contributed equally to the manuscript. Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. It is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion Citation: Scala, E.; Cacciapuoti, S.; of the folliculopilosebaceous unit, followed by follicular rupture and immune responses. Innate Garzorz-Stark, N.; Megna, M.; pro-inflammatory cytokines (e.g., IL-1β, and TNF-α); mediators of activated T helper (Th)1 and Th17 Marasca, C.; Seiringer, P.; Volz, T.; cells (e.g., IFN-γ, and IL-17); and effector mechanisms of neutrophilic granulocytes, macrophages, Eyerich, K.; Fabbrocini, G.
    [Show full text]
  • Personalized Medicine—Concepts, Technologies, and Applications in Inflammatory Skin Diseases
    Personalized medicine - concepts, technologies, and applications in inflammatory skin diseases Litman, T. Published in: APMIS - Journal of Pathology, Microbiology and Immunology DOI: 10.1111/apm.12934 Publication date: 2019 Document version Publisher's PDF, also known as Version of record Document license: CC BY Citation for published version (APA): Litman, T. (2019). Personalized medicine - concepts, technologies, and applications in inflammatory skin diseases. APMIS - Journal of Pathology, Microbiology and Immunology, 127(5), 386-424. https://doi.org/10.1111/apm.12934 Download date: 09. apr.. 2020 JOURNAL OF PATHOLOGY, MICROBIOLOGY AND IMMUNOLOGY APMIS 127: 386–424 © 2019 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology. DOI 10.1111/apm.12934 Review Article Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases THOMAS LITMAN1,2 1Department of Immunology and Microbiology, University of Copenhagen, Copenhagen; 2Explorative Biology, Skin Research, LEO Pharma A/S, Ballerup, Denmark Litman T. Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases. APMIS 2019; 127: 386–424. The current state, tools, and applications of personalized medicine with special emphasis on inflammatory skin diseases like psoriasis and atopic dermatitis are discussed. Inflammatory pathways are outlined as well as potential targets for monoclonal antibodies and small-molecule inhibitors. Key words: Atopic dermatitis; endotypes; immunology; inflammatory skin diseases; personalized medicine; precision medicine; psoriasis; targeted therapy. Thomas Litman, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. e-mail: [email protected] and Explorative Biology, Skin Research, LEO Pharna A/S, Ballerup, Denmark. e-mail: [email protected] INTRODUCTION – WHY? proteins (4, 5).
    [Show full text]
  • Lääkeaineiden Yleisnimet (INN-Nimet) 21.6.2021
    Lääkealan turvallisuus- ja kehittämiskeskus Säkerhets- och utvecklingscentret för läkemedelsområdet Finnish Medicines Agency Lääkeaineiden yleisnimet (INN-nimet) 21.6.
    [Show full text]
  • Inflarx N.V. (Exact Name of Registrant As Specified in Its Charter)
    UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . OR ☐ SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of event requiring this shell company report Commission file number: 001-38283 InflaRx N.V. (Exact name of Registrant as specified in its charter) The Netherlands (Jurisdiction of incorporation or organization) Winzerlaer Str. 2 07745 Jena, Germany (+49) 3641 508 180 (Address of principal executive offices) Dr. Thomas Taapken, Chief Financial Officer Tel: (+49) 89 4141 897 800 Fraunhoferstr. 22, 82152 Planegg-Martinsried, Germany (Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person) Copies to: Sophia Hudson Kirkland & Ellis LLP 601 Lexington Avenue New York, NY 10022 Phone: (212) 446-4750 Securities registered or to be registered pursuant to Section 12(b) of the Act: Title of each class Trading Symbol(s) Name of each exchange on which registered Common Shares, nominal value €0.12 per share IFRX The NASDAQ Stock Market LLC Securities registered or to be registered pursuant to Section 12(g) of the Act: None Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act: None Indicate the number of outstanding shares of each of the issuer’s classes of capital or common stock as of the close of the period covered by the annual report.
    [Show full text]
  • NETTER, Jr., Robert, C. Et Al.; Dann, Dorf- (21) International Application
    ll ( (51) International Patent Classification: (74) Agent: NETTER, Jr., Robert, C. et al.; Dann, Dorf- C07K 16/28 (2006.01) man, Herrell and Skillman, 1601 Market Street, Suite 2400, Philadelphia, PA 19103-2307 (US). (21) International Application Number: PCT/US2020/030354 (81) Designated States (unless otherwise indicated, for every kind of national protection av ailable) . AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 29 April 2020 (29.04.2020) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (25) Filing Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/840,465 30 April 2019 (30.04.2019) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM, TN, TR, (71) Applicants: INSTITUTE FOR CANCER RESEARCH TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM, ZW. D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER [US/US]; 333 Cottman Av¬ (84) Designated States (unless otherwise indicated, for every enue, Philadelphia, PA 191 11-2497 (US). UNIVERSTIY kind of regional protection available) . ARIPO (BW, GH, OF KANSAS [US/US]; 245 Strong Hall, 1450 Jayhawk GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Boulevard, Lawrence, KS 66045 (US).
    [Show full text]
  • Topical and Systematic Treatment of Atopic Dermatitis to Inform a Clinical Practice Guideline
    Topical and Systemic Treatment of Atopic Dermatitis Results of Topic Selection Process & Next Steps The nominator American Academy of Dermatology, is interested in a new evidence review on Topical and Systematic Treatment of Atopic Dermatitis to inform a clinical practice guideline. We identified several review(s) covering part of the scope of the nomination, therefore, a new review would be partially duplicative of an existing product. For the questions not covered by existing reviews, there is limited original research. No further activity on this nomination will be undertaken by the Effective Health Care (EHC) Program. Topic Brief Topic Numbers and Name: #0804, 0805, 0806 Topical and Systemic Treatment of Atopic Dermatitis Nomination Date: 7/09/2018 Topic Brief Date: 10/11/2018 Authors Elise Berliner Conflict of Interest: None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. 1 Background Atopic dermatitis is a common chronic skin condition that causes itchy scaly red patches. The 1-year US prevalence of AD was estimated at 12.98% in children in 2007-2008 and 7.2%-10.2% in adults in 2010-20121. There is no biomarker, objective diagnostic test, or even standard nomenclature for describing atopic dermatitis and related conditions such as other forms of eczema. NIH has funded an initiative to harmonize outcome measures in atopic dermatitis.2 Patients with atopic dermatitis typically try to control their symptoms through supportive care including bathing and moisturizing ointments, wearing soft breathable fabrics and avoiding contact with allergens. The current American Academy of Dermatology guidelines do not recommend non-sedating antihistamines for atopic dermatitis, but recognize that sedating antihistamines may have value in controlling insomnia secondary to itching.
    [Show full text]
  • Ulipristal Acetate
    WHO D rug Information WHO Drug Information provides an overview of topics relating to medicines development, regulation, quality and safety. The journal also publishes and reports on guidance documents and includes lists of International Nonproprietary Names for Pharmaceutical Substances (INN), ATC/DDD classification and monographs for The International Pharmacopoeia. It presents and describes WHO policies and activities while reflecting on technical and pharmaceutical topics of international and regional interest. WHO Drug Information is published four times a year and can be ordered from: WHO Press, World Health Organization, 1211 Geneva 27, Switzerland. e-mail: [email protected] or on line at http://www.who.int/bookorders WHO Drug Information can be viewed at: https://www.who.int/our-work/access-to-medicines-and-health-products/who-drug-information WHO Drug Information, Vol. 35, No. 2, 2021 ISBN 978-92-4-003205-7 (electronic version) ISBN 978-92-4-003206-4 (print version) ISSN 1010-9609 © World Health Organization 2021 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC- SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence.
    [Show full text]