DOCSLIB.ORG

Altered Fovea in AQP4-Igg–Seropositive Neuromyelitis Optica Spectrum Disorders E805

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Altered Fovea in AQP4-Igg–Seropositive Neuromyelitis Optica Spectrum Disorders E805 Volume 7, Number 5, September 2020 Neurology.org/NN A peer-reviewed clinical and translational neurology open access journal ARTICLE Altered fovea in AQP4-IgG–seropositive neuromyelitis optica spectrum disorders e805 ARTICLE Treatment and outcome of aquaporin-4 antibody–positive NMOSD: A multinational pediatric study e837 ARTICLE Guillain-Barré syndrome: Th e fi rst documented COVID-19–triggered autoimmune neurologic disease: More to come with myositis in the offi ng e781 ARTICLE Extending rituximab dosing intervals in patients with MS during the COVID-19 pandemic and beyond? e825 Academy Officers Neurology® is a registered trademark of the American Academy of Neurology (registration valid in the United States). James C. Stevens, MD, FAAN, President Neurology® Neuroimmunology & Neuroinflammation (eISSN 2332-7812) is an Orly Avitzur, MD, MBA, FAAN, President Elect open access journal published online for the American Academy of Neurology, Ann H. Tilton, MD, FAAN, Vice President 201 Chicago Ave, Minneapolis, MN 55415, by Wolters Kluwer Health, Inc. at 14700 Citicorp Drive, Bldg 3, Hagerstown, MD 21742. Business offices are Carlayne E. Jackson, MD, FAAN, Secretary located at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD Janis M. Miyasaki, MD, MEd, FRCPC, FAAN, Treasurer 21201-2436. © 2020 American Academy of Neurology. Ralph L. Sacco, MD, MS, FAAN, Past President Neurology® Neuroimmunology & Neuroinflammation is an official journal of the American Academy of Neurology. Journal website: Neurology.org/NN, AAN website: AAN.com CEO, American Academy of Neurology Copyright and Permission Information: Please go to the journal website Mary E. Post, MBA, CAE (www.neurology.org/nn) and click the Permissions tab for the relevant article. Chief Executive Officer Alternatively, send an email to [email protected]. General information about permissions can be found here: https://www.lww.com/ 201 Chicago Ave journal-permission. Minneapolis, MN 55415 Disclaimer: Opinions expressed by the authors and advertisers are not necessarily those of the American Academy of Neurology, its affiliates, or of Tel: 612-928-6100 the Publisher. The American Academy of Neurology, its affiliates, and the Publisher disclaim any liability to any party for the accuracy, completeness, efficacy, or availability of the material contained in this publication (including Editorial Office drug dosages) or for any damages arising out of the use or non-use of any of the Patricia K. Baskin, MS, Executive Editor material contained in this publication. Rachel A. Anderson, Administrative Assistant Advertising Sales Representatives: Wolters Kluwer, 333 Seventh Avenue, New York, NY 10001. Contacts: Eileen Henry, tel: 732-778-2261, fax: 973-215-2485, [email protected] and in Europe: Craig Silver, tel: +44 7855 Morgan S. Sorenson, Managing Editor 062 550 or e-mail: [email protected]. fl Careers & Events: Monique McLaughlin, Wolters Kluwer, Two Commerce Neurology® Neuroimmunology & Neuroin ammation Square, 2001 Market Street, Philadelphia, PA 19103, tel: (215)-521- 8468, fax: Neurology® Genetics 215-521-8801; [email protected]. Reprints: Meredith Edelman, Commercial Reprint Sales, Wolters Kluwer, Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, tel: Kathleen M. Pieper, Senior Managing Editor, Neurology® 215-356-2721; [email protected]; reprintsolutions@ Karen Skaja, Senior Editorial Coordinator wolterskluwer.com. Skyler M. Kane, Editorial Coordinator Special projects: US & Canada: Alan Moore, Wolters Kluwer, Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, tel: 215-521-8638, Margaret A. Rei, Editorial Coordinator [email protected]. International: Andrew Wible, Senior Manager, Rights, Licensing, and Partnerships, Wolters Kluwer, translationrights@ wolterskluwer.com. Lee Ann Kleffman, Managing Editor, Neurology® Clinical Practice Andrea Rahkola, Production Editor Kristen Swendsrud, Production Coordinator Sharon L. Quimby, Digital Managing Editor Kaitlyn Aman Ramm, Digital Multimedia/Graphics Coordinator Justin Daugherty, Digital Multimedia/Podcast Coordinator Madeleine Sendek, MPH, Digital Marketing Communications Coordinator Publisher Wolters Kluwer Baltimore, MD Publishing Staff Sarah Carrera, MBA, Executive Publisher Jessica Heise, Production Team Leader, Neurology Journals Megen Miller, Production Editor Stacy Drossner, Production Associate Copyright © 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited. A peer-reviewed clinical and translational neurology open access journal Neurology.org/NN Neurology® Neuroimmunology & Neuroinflammation Editor JosepO.Dalmau,MD,PhD Vision Neurology® Neuroimmunology & Neuroinflammation will be the premier Deputy Editor peer-reviewed journal in the fields of Scott S. Zamvil, MD, PhD, FAAN neuroimmunology and neuroinflammation. Associate Editors Marinos Dalakas, MD, FAAN Mission Neurology: Neuroimmunology & Michael Heneka, MD Neuroinflammation will provide neurologists Dennis Kolson, MD, PhD and clinical research scientists with Friedmann Paul, MD outstanding peer-reviewed articles, editorials, Editorial Board and reviews to enhance patient care and Rohit Aggarwal, MD, MS Jun Li, MD, PhD facilitate basic and translational research. Sergio E. Baranzini, PhD Lin Mei, MD, PhD Susanne Benseler, MD Andrew McKeon, MD Jeffrey L. Bennett, MD, PhD, FAAN Christopher Power, MD Editorial Tel: 612-928-6400 S´everine Boill´ee, PhD Richard M. Ransohoff,MD Inquiries Toll-free: 800-957-3182 (US) Matthijs C. Brouwer, MD, PhD Christine Stadelmann, MD Fax: 612-454-2748 Wolfgang Br¨uck, MD Israel Steiner, MD [email protected] David B. Clifford, MD, FAAN Lawrence Steinman, MD Russell C. Dale, MBChB, MRCP, PhD Jesper Tegn´er, PhD, MSc Oscar H. Del Brutto, MD, FAAN Silvia N. Tenembaum, MD Stay facebook.com/NeurologyNN Thomas G. Forsthuber, MD Maarten J. Titulaer, MD, PhD Connected Kazuo Fujihara, MD Ari Waisman, PhD twitter.com/greenjournal Jeffrey M. Gelfand, MD, MAS, FAAN Hugh J. Willison, MBBS, PhD Joseph El Khoury, MD Gregory F. Wu, MD, PhD youtube.com/user/NeurologyJournal Markus P. Kummer, PhD instagram.com/aanbrain Neurology® Journals Editor-in-Chief Classification of Evidence Review Team Jos´eG.Merino,MD,MPhil,FAAN Melissa J. Armstrong, MD Richard L. Barbano, MD, PhD, FAAN Deputy Editor Richard M. Dubinsky, MD, MPH, FAAN Olga Ciccarelli, MD, PhD, FRCP Jeffrey J. Fletcher, MD, MSc Gary M. Franklin, MD, MPH, FAAN Section Editors David S. Gloss II, MD, MPH&TM Biostatistics John J. Halperin, MD, FAAN Richard J. Kryscio, PhD Jason Lazarou, MSc, MD Sue Leurgans, PhD Steven R. Mess´e, MD, FAAN V. Shane Pankratz, PhD Pushpa Narayanaswami, MBBS, DM, FAAN Alex Rae-Grant, MD Classification of Evidence Evaluations Gary S. Gronseth, MD, FAAN Equity, Diversity, & Inclusion RoyH.Hamilton,MD,MS,FAAN Holly E. Hinson, MD, MCR, FAAN Podcasts Stacey L. Clardy, MD, PhD, FAAN Jeffrey B. Ratliff, MD, Deputy Podcast Editor Ombudsman Jonathan W. Mink, MD, PhD, FAAN Scientific Integrity Advisor David S. Knopman, MD, FAAN Copyright © 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited. TABLE OF CONTENTS Volume 7, Number 5, September 2020 Neurology.org/NN e807 Ocrelizumab shorter infusion: Primary results from the ENSEMBLE PLUS substudy in patients with MS H.-P. Hartung, on behalf of the ENSEMBLE Steering Committee members and study investigators Open Access Class of Evidence e805 Altered fovea in AQP4-IgG–seropositive neuromyelitis optica spectrum disorders S. Motamedi, F.C. Oertel, S.K. Yadav, E.M. Kadas, M. Weise, J. Havla, Cover Image M. Ringelstein, O. Aktas, P. Albrecht, K. Ruprecht, J. Bellmann-Strobl, 3D foveal shape analysis method overview. The left panel shows inner H.G. Zimmermann, F. Paul, and A.U. Brandt limiting membrane surface smoothing and radial reconstruction using the Open Access cubic Bezier polynomial. The right panel shows rim disk (blue), slope fl e809 Recent cannabis use in HIV is associated with reduced disk (red), and pit at disk (green). The lower panel shows rim height, fl average pit depth, and central foveal thickness. Stylized by Kaitlyn Aman in ammatory markers in CSF and blood Ramm, Digital Multimedia/Graphics Coordinator. R.J. Ellis, S.N. Peterson, Y. Li, R. Schrier, J. Iudicello, S. Letendre, E. Morgan, B. Tang, I. Grant, and M. Cherner See page e805 Open Access Editor’s Corner e817 Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy e858 N2 in the time of COVID-19 L. Appeltshauser, A.-M. Brunder, A. Heinius, P. Kortv¨ ´elyessy, J. Dalmau K.-P. Wandinger, R. Junker, C. Villmann, C. Sommer, F. Leypoldt, and K. Doppler Open Access Open Access Editorial, p. e843 Editorial e815 CSF chitinase 3-like-1 association with disability of e843 Isotyping paranodal antibodies in inflammatory primary progressive MS neuropathies: One step closer to precision care F. P´erez-Miralles, D. Prefasi, A. Garc´ıa-Merino, F. Gascon-Gim´ ´enez, N. Medrano, J. Castillo-Villalba, L. Cubas, C. Alcal´a, S. Gil-Perot´ın, C. Lleix`a and L. Querol R. Gomez-Ballesteros,´ J. Maurino, E. Alvarez-Garc´ ´ıa, and Open Access B. Casanova Open Access Class of Evidence Articles e819 Painful trigeminal neuropathy associated with e781 Guillain-Barr´e syndrome: The first documented anti-Plexin D1 antibody COVID-19–triggered autoimmune neurologic T. Fujii, R. Yamasaki, Y. Miyachi, K. Iinuma, Y. Hashimoto, N. Isobe,
Load more

Recommended publications
  • © Degli Aventi Diritto Anteprima » Panini Comics BOB 84 © Degli Aventi Diritto © Degli Aventi
    © degli aventi diritto Anteprima » Panini Comics BOB 84 © degli aventi diritto © degli aventi Bob Sinatra è un killer a pagamento che si muove attraverso l’Europa pop degli anni 80, tra loschi affari e criminalità organizzata. Ama le belle donne, le auto da corsa e non chiede mai perché, ma solo “Quanto?”. Autori: Vincenzo Filosa, Come se non bastasse, somiglia a un certo cantante… A dargli filo da Paolo Bacilieri torcere un commissario italiano che ha fatto della cattura del nostro Aprile • 13x18, B., 160 pp., b/n • Euro 12,00 Bob la sua ragione di vita. Vincenzo Filosa (Viaggio a Tokyo, Italo) e Paolo Bacilieri (Napoleone, Fun, Ettore e Fernanda) firmano un noir dai tratti decisi e dall’umorismo tagliente che ricorda i polizieschi anni 80 ma anche i manga d’autore. 95 Anteprima » Panini Comics IL NEGOZIO DI PETER © degli aventi diritto © degli aventi New York, anni 30. Nel negozio di Peter, quattro simpatiche canaglie pennute dettano legge. Finché un giorno non accade qualcosa che Autori: Andrea Greppi, Maria Claudia Di Genova, Bruno Enna sconvolge il loro mondo… Da un team creativo d’eccezione di autori Aprile • 21,8x28,7, C., Disney, un’avventura fuori dagli schemi che tra risate, colpi di scena 48 pp., col. • Euro 12,90 e di coda vi regalerà un messaggio delizioso che vi scalderà il cuore. 96 Anteprima » Panini Comics A LEZIONE DI KAWAII © degli aventi diritto © degli aventi Impara a disegnare con lo youtuber 365bocetos! Il libro definitivo per tutti gli appassionati del disegno Kawaii con tutti i suoi animaletti Autore: José Antonio Pérez e oggetti super-cutie! Oltre 60 tutorial per imparare a rendere tutto Aprile • 18x24, B.
    [Show full text]
  • Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 6 April 2021 doi:10.20944/preprints202104.0161.v1 Review Sphingolipids and cell signaling: Relationship between health and disease in the central nervous system Andrés Felipe Leal1, Diego A. Suarez1,2, Olga Yaneth Echeverri-Peña1, Sonia Luz Albarracín3, Carlos Javier Alméciga-Díaz1*, Angela Johana Espejo-Mojica1* 1 Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C., 110231, Colombia; [email protected] (A.F.L.), [email protected] (D.A.S.), [email protected] (O.Y.E.P.) 2 Faculty of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia; [email protected] (D.A.S.) 3 Nutrition and Biochemistry Department, Faculty of Science, Pontificia Universidad Javeriana, Bogotá D.C., Colombia; [email protected] (S.L.A.) * Correspondence: [email protected]; Tel.: +57-1-3208320 (Ext 4140) (C.J.A-D.). [email protected]; Tel.: +57-1-3208320 (Ext 4099) (A.J.E.M.) Abstract Sphingolipids are lipids derived from an 18-carbons unsaturated amino alcohol, the sphingosine. Ceramide, sphingomyelins, sphingosine-1-phosphates, gangliosides and globosides, are part of this group of lipids that participate in important cellular roles such as structural part of plasmatic and organelle membranes maintaining their function and integrity, cell signaling response, cell growth, cell cycle, cell death, inflammation, cell migration and differentiation, autophagy, angiogenesis, immune system. The metabolism of these lipids involves a broad and complex network of reactions that convert one lipid into others through different specialized enzymes. Impairment of sphingolipids metabolism has been associated with several disorders, from several lysosomal storage diseases, known as sphingolipidoses, to polygenic diseases such as diabetes and Parkinson and Alzheimer diseases.
    [Show full text]
  • GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies
    International Journal of Molecular Sciences Review GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies Andrés Felipe Leal 1 , Eliana Benincore-Flórez 1, Daniela Solano-Galarza 1, Rafael Guillermo Garzón Jaramillo 1 , Olga Yaneth Echeverri-Peña 1, Diego A. Suarez 1,2, Carlos Javier Alméciga-Díaz 1,* and Angela Johana Espejo-Mojica 1,* 1 Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia; [email protected] (A.F.L.); [email protected] (E.B.-F.); [email protected] (D.S.-G.); [email protected] (R.G.G.J.); [email protected] (O.Y.E.-P.); [email protected] (D.A.S.) 2 Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 110231, Colombia * Correspondence: [email protected] (C.J.A.-D.); [email protected] (A.J.E.-M.); Tel.: +57-1-3208320 (ext. 4140) (C.J.A.-D.); +57-1-3208320 (ext. 4099) (A.J.E.-M.) Received: 6 July 2020; Accepted: 7 August 2020; Published: 27 August 2020 Abstract: GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside accumulation into the lysosome due to mutations on the genes encoding for the β-hexosaminidases subunits or the GM2 activator protein. Three GM2 gangliosidoses have been described: Tay–Sachs disease, Sandhoff disease, and the AB variant. Central nervous system dysfunction is the main characteristic of GM2 gangliosidoses patients that include neurodevelopment alterations, neuroinflammation, and neuronal apoptosis. Currently, there is not approved therapy for GM2 gangliosidoses, but different therapeutic strategies have been studied including hematopoietic stem cell transplantation, enzyme replacement therapy, substrate reduction therapy, pharmacological chaperones, and gene therapy.
    [Show full text]
  • A Critical Method for Analyzing the Rhetoric of Comic Book Form. Ralph Randolph Duncan II Louisiana State University and Agricultural & Mechanical College
    Louisiana State University LSU Digital Commons LSU Historical Dissertations and Theses Graduate School 1990 Panel Analysis: A Critical Method for Analyzing the Rhetoric of Comic Book Form. Ralph Randolph Duncan II Louisiana State University and Agricultural & Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_disstheses Recommended Citation Duncan, Ralph Randolph II, "Panel Analysis: A Critical Method for Analyzing the Rhetoric of Comic Book Form." (1990). LSU Historical Dissertations and Theses. 4910. https://digitalcommons.lsu.edu/gradschool_disstheses/4910 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Historical Dissertations and Theses by an authorized administrator of LSU Digital Commons. For more information, please contact [email protected]. INFORMATION TO USERS The most advanced technology has been used to photograph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The qualityof this reproduction is dependent upon the quality of the copysubmitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps.
    [Show full text]
  • Toward a Theory of the Dark Fantastic: the Role of Racial Difference in Young Adult Speculative Fiction and Media
    Journal of Language and Literacy Education Vol. 14 Issue 1—Spring 2018 Toward a Theory of the Dark Fantastic: The Role of Racial Difference in Young Adult Speculative Fiction and Media Ebony Elizabeth Thomas Abstract: Humans read and listen to stories not only to be informed but also as a way to enter worlds that are not like our own. Stories provide mirrors, windows, and doors into other existences, both real and imagined. A sense of the infinite possibilities inherent in fairy tales, fantasy, science fiction, comics, and graphic novels draws children, teens, and adults from all backgrounds to speculative fiction – also known as the fantastic. However, when people of color seek passageways into &the fantastic, we often discover that the doors are barred. Even the very act of dreaming of worlds-that-never-were can be challenging when the known world does not provide many liberatory spaces. The dark fantastic cycle posits that the presence of Black characters in mainstream speculative fiction creates a dilemma. The way that this dilemma is most often resolved is by enacting violence against the character, who then haunts the narrative. This is what readers of the fantastic expect, for it mirrors the spectacle of symbolic violence against the Dark Other in our own world. Moving through spectacle, hesitation, violence, and haunting, the dark fantastic cycle is only interrupted through emancipation – transforming objectified Dark Others into agentive Dark Ones. Yet the success of new narratives fromBlack Panther in the Marvel Cinematic universe, the recent Hugo Awards won by N.K. Jemisin and Nnedi Okorafor, and the blossoming of Afrofuturistic and Black fantastic tales prove that all people need new mythologies – new “stories about stories.” In addition to amplifying diverse fantasy, liberating the rest of the fantastic from its fear and loathing of darkness and Dark Others is essential.
    [Show full text]
  • Not 310307.Qxp
    Somascan Fathers via di Casal Morena, 8 * 00040 MORENA-ROMA Tel. 06/72.33.580 Fax 06/72.33.575 [email protected] ufficio stampa crs * © 31th March 2007 Election of the Fourth General Councilor mans. After some negotiations, only one During the past Consulta 2007, held in Tagay- hostage will be executed, while the others will tay (Philippines), on February 24, Fr. Aldo be released. He has ministered in different Gazzano was elected as fourth General Coun- communities, as a formation director of postu- cilor. Best wishes for a fruitful work as a lancy and as a zealous pastor in the splendid Councilor! Church restored by him, Santa Maria del Popolo in Cherasco. He has been teacher for The Goal many years at Nervi’s College and he minis- On March 19, at the Curia General, the special tered with great attention to some female reli- moment of Somascan renewal, part of the gious Congregations. To the Somascan family great project of ongoing formation, has begun. he left the memory of being an exemplary reli- The following religious are present: Bro. Aldo gious of profound spiritual life and of continu- Bettineschi (Como, Annunciata), Fr. Gi- al prayer. ambattista Guazzi ( Villa San Giovanni, Par- rocchia del Rosario), Fr. Antonio Zavattin Fr. Jose de Cupertino Cruz González (Romania Delegation), Fr. Dante Cagnasso The Lord called him on February 13, at the age (Narezole, Villaggio della Gioia), Fr. Giancarlo of 72. Born in Sensuntepeque (El Salvador), he Rinaldi (San Mauro Torinese, Villa Speranza), has studied philosophy and theology at the Fr. Gaetano sacchi (San Salvador, La Ceiba Seminary of Magenta (Mi) and was ordained de Guadalupe), Fr.
    [Show full text]
  • Newsletter Summer 07 V1.Pub
    NON-PROFIT ORG. U.S. POSTAGE P AID CHICOPEE, MA 01021 Permit No. 56 THE ANCHOR “… to hold fast to the hope that lies before us. This we have as an anchor of the soul, sure and firm,…” (Heb 6:18,19) APOSTOLATE OF THE SUFFERING 60 60 th ANNIVERSARY We rejoice on this special year of the 60 ththth Anniversary of the foundation of the Apostolate of the Suffering, whose founders, were guided and inspired in all aspects of the association, by the maternal inspiration of our Blessed Mother. In 1947, Msgr. Novarese, along with Sister Elvira Myriam Psorulla, born in Haifa, and whom he had met providentially, founded the Apostolate of the Suffering. The elder Sister, to this day, continues to make her home above the church where is entombed our Founding Father the Servant of God, Msgr. Luigi Novarese. The 60 th Anniversary celebrations recently opened with the partici- pation of nine hundred International Members of the Apostolate of the Suffering on the 23 rd of May in Rome, with recognition by the Holy Father and a Mass in St Peter’s Basilica. Brother Bob Letasz, our American Director, was fortunate enough to be there at the time, as he was attending a Council Meeting of the International Msgr. Luigi Novarese Confederation. Our 60 th Anniversary Jubilee will conclude with a Pilgrimage to Fatima in October to participate in the 90th Anniversary celebra- tion of Our Lady of Fatima’s final apparition ‘The Miracle of the Sun’ in the Cova da Iria. “YOU,YOU, DEAREST ONES, CAN PARTICIPATE IN THE SALVATION OF HUMANITY, IF YOU UNITE YOUR PAIN,YOUR TRIALS TO THOSE OF Sr.
    [Show full text]
  • List of Compounds 2018 年12 月
    List of Compounds 2018 年12 月 長良サイエンス株式会社 Nagara Science Co., Ltd. 〒501-1121 岐阜市古市場 840 840 Furuichiba, Gifu 501-1121, JAPAN Phone : +81-58-234-4257、Fax : +81-58-234-4724 E-mail : [email protected] 、http : //www.nsgifu.jp Storage Product Name・Purity・Molecular Formula＝Molecular Weight・〔 CAS Quantity Source Code No. C o n di t i o n s Registry Number 〕 ・Price ( JPY ) NH020102 2－10 ℃ (-)-Epicatechin [ (-)-EC ] ≧99% (HPLC) 10mg 8,000 NH020103 C15H14O6 = 290.27 〔490-46-0〕 100mg 44,000 NH020202 2－10 ℃ (-)-Epigallocatechin [ (-)-EGC ] ≧99% (HPLC) 10mg 12,000 NH020203 C15H14O7 = 306.27 〔970-74-1〕 100mg 66,000 NH020302 2－10 ℃ (-)-Epicatechin gallate [ (-)-ECg ] ≧99% (HPLC) 10mg 12,000 NH020303 C22H18O10 = 442.37 〔1257-08-5〕 100mg 52,000 NH020403 2－10 ℃ (-)-Epigallocatechin gallate [ (-)-EGCg ] ≧98% (HPLC) 100mg 12,000 〔 〕 C22H18O11 = 458.37 989-51-5 NH020602 2－10 ℃ (-)-Epigallocatechin gallate [ (-)-EGCg ] ≧99% (HPLC) 20mg 12,000 NH020603 C22H18O11 = 458.37 〔989-51-5〕 100mg 30,000 NH020502 2－10 ℃ (+)-Catechin hydrate [ (+)-C ] ≧99% (HPLC) 10mg 5,000 NH020503 C15H14O6 ･H2O = 308.28 〔88191-48-4〕 100mg 32,000 NH021102 2－10 ℃ (-)-Catechin [ (-)-C ] ≧98% (HPLC) 10mg 23,000 C15H14O6 = 290.27 〔18829-70-4〕 NH021202 2－10 ℃ (-)-Gallocatechin [ (-)-GC ] ≧98% (HPLC) 10mg 34,000 〔 〕 C15H14O7 = 306.27 3371-27-5 NH021302 － ℃ ≧ 10mg 34,000 2 10 (-)-Catechin gallate [ (-)-Cg ] 98% (HPLC) C22H18O10 = 442.37 〔130405-40-2〕 NH021402 2－10 ℃ (-)-Gallocatechin gallate [ (-)-GCg ] ≧98% (HPLC) 10mg 23,000 C22H18O11 = 458.37 〔4233-96-9〕 NH021502 2－10 ℃ (+)-Epicatechin [ (+)-EC
    [Show full text]
  • Press Release: the Jubilee for Workers of Mercy and Volunteers About to Start on Friday, 2 September 31-8-2016 PCPNE
    Press release: The Jubilee for Workers of Mercy and Volunteers about to start on Friday, 2 September 31-8-2016 PCPNE On Sunday, the Canonization of Blessed Mother Teresa of Calcutta To bring comfort through a visit to someone sick, to give a smile and friendship to our disabled brothers and sisters, to offer a little of your time to the imprisoned: these are a few of the works of mercy that are depicted in a video accessible through the hashtag #BeMercy, found on the social media of the Jubilee of Mercy. The video promotes the Jubilee event dedicated to volunteers and workers of Mercy, scheduled to take place in Rome between 2-4 September. The Pope’s invitation is directed to everyone throughout the world, because each of us in the Jubilee of Mercy is called to be a worker of mercy, carrying out concrete actions and gestures of Mercy. Through the hashtag #BeMercy, those who cannot come to Rome are invited to participate by sharing their own testimonies about volunteering. The Jubilee event will culminate on Sunday, 4 September, with Mass at 10:30, during which Blessed Mother Teresa of Calcutta, an untiring model as a Worker for the Mercy of God, will be canonized. This Jubilee will have as a particular focus the central region of the Italian Peninsula and the victims of the devastating earthquake there, along with all the volunteers who have hastened to help the tragic situation. - 1 - On Friday, 2 September, the Jubilee for Workers of Mercy and Volunteers will begin at 14:00 with several options of activities, which will continue to be available on Saturday afternoon as well.
    [Show full text]
  • Mouse Model of GM2 Activator Deficiency Manifests Cerebellar Pathology and Motor Impairment
    Proc. Natl. Acad. Sci. USA Vol. 94, pp. 8138–8143, July 1997 Medical Sciences Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment (animal modelyGM2 gangliosidosisygene targetingylysosomal storage disease) YUJING LIU*, ALEXANDER HOFFMANN†,ALEXANDER GRINBERG‡,HEINER WESTPHAL‡,MICHAEL P. MCDONALD§, KATHERINE M. MILLER§,JACQUELINE N. CRAWLEY§,KONRAD SANDHOFF†,KINUKO SUZUKI¶, AND RICHARD L. PROIA* *Section on Biochemical Genetics, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, ‡Laboratory of Mammalian Genes and Development, National Institute of Child Health and Development, and §Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; †Institut fu¨r Oganische Chemie und Biochemie der Universita¨tBonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany; and ¶Department of Pathology and Laboratory Medicine, and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599 Communicated by Stuart A. Kornfeld, Washington University School of Medicine, St. Louis, MO, May 12, 1997 (received for review March 21, 1997) ABSTRACT The GM2 activator deficiency (also known as disorder, the respective genetic lesion results in impairment of the AB variant), Tay–Sachs disease, and Sandhoff disease are the the degradation of GM2 ganglioside and related substrates. major forms of the GM2 gangliosidoses, disorders caused by In humans, in vivo GM2 ganglioside degradation requires the defective degradation of GM2 ganglioside. Tay–Sachs and Sand- GM2 activator protein to form a complex with GM2 ganglioside. hoff diseases are caused by mutations in the genes (HEXA and b-Hexosaminidase A then is able to interact with the activator- HEXB) encoding the subunits of b-hexosaminidase A.
    [Show full text]
  • LIBRI ENTRATI in BIBLIOTECA NEL MESE DI Gennaio 2017
    giovedì 14 dicembre 2017 Libri entrati dal 1 gennaio al 31 gennaio 2017. Totale records n. 236 LIBRI ENTRATI IN BIBLIOTECA NEL MESE DI Gennaio 2017 Autore Titolo Editore Anno ISBN Gronchi, Maurizio, sac., Jesucristo / Urbaniana University Press ; ©2017. 978-88-401-7059-6 Dizionario hindu-cristiano : luoghi per il dialogo Urbaniana University Press, 2017. 978-88-401-5041-3 interreligioso / PUU – BIBLIOTECA Pag. 1 giovedì 14 dicembre 2017 Libri entrati dal 1 gennaio al 31 gennaio 2017. Totale records n. 236 Vangelo e culture : per nuovi incontri / Urbaniana University Press, 2017. 978-88-401-6032-0 The evolving consciousness and the dynamics of Abishegam, Harry Manuel, religion : an inquiry into the thought of A.N. [s.n.], 2016. O.M.I., Whitehead and Sri Aurobindo / Aguti, Andrea, Introduzione alla filosofia della religione / La Scuola, ©2016. 978-88-350-4541-0 A Dio appartengono i nomi più belli : come pregano i Allievi, Stefano, EDB, 2016. 978-88-10-56741-8 musulmani / Dalla stessa radice : ebrei e cristiani, un dialogo Altamore, Giuseppe. Lindau, 2016. 978-88-6708-542-2 intrareligioso / Il prestito nella tradizione cristiana : una questione Amelio, Massimo. Cantagalli, 2016. 978-88-687-9349-4 controversa / Ecologia integrale : Laudato si': ricerca, formazione, Vita e pensiero, 2016. 978-88-343-3227-6 conversione / Antonelli, Ennio, card., Per vivere l'"Amoris laetitia" / Ares, 2016. 978-88-8155-705-9 La missione crea comunione : dall'Africa un nuovo Arena, Domenico, O.M.I. EMI, 2016. 978-88-307-2368-9 paradigma per l'annuncio / Arletti, Claudio. Pentateuco / EDB, 2016. 978-88-10-43209-9 PUU – BIBLIOTECA Pag.
    [Show full text]
  • Agosto 1934 - Xii - N
    1° AGOSTO 1934 - XII - N. 8 ANNO LVIII BOLLETTINO Sommario : Dopo la Canonizza- zione dl Don Bosco . - Crociata Mis-- sionaria . - In famiglia . - Dalle nostre Missioni . Siam - Cina - Giappone. - SALESIANO Echi delle feste a D. Bosco Santo . - PERIODICO MENSILE PER I COOPERATORI Culto e Grazie di M . A . - Per in DELLE OPERE E MISSIONI DI DON BOSCO tercessione di San Giovanni Bosco. - Necrologio. Dopo la Canonizzazione di Don Bosco Le Feste passano: tutte, anche le più care, semplice, spontanea, cordiale, eucaristica; spi- anche quelle che, nell'anno della Canonizzazione, rito di filiale attaccamento alla santa Chiesa ed tutto il mondo va tributando a Don Bosco Santo . al Vicario di Cristo; spirito di apostolato indu- Ma se passano le feste, non deve passare il Santo, strioso e generoso per la salvezza delle anime . ad onta del proverbio . La Chiesa infatti l'ha Le feste celebrate ad onore di Don Bosco Santo innalzato sugli altari, perchè sugli altari Egli sono riuscite ovunque una vera missione, a ca- resti, ispiratore, modello e tutore della nostra rattere eminentemente eucaristico . Segno ch'egli vita. La parola d'ordine trasmessa ai Coopera- ha toccato profondamente i cuori e suscitato quel tori nei vari Convegni di quest'anno fu una sola gran bene per le anime che il S . Padre già si ri- per tutti : propagare il culto, e vivere e diffondere prometteva quando fissava per la data della Cano- lo spirito di S . Giovanni Bosco. « Avvolgerci nizzazione il gran giorno di Pasqua . Quante nella luce che s'irradia dalla santità del nostro Pasque ha, fatto fare Don Bosco Santo e quanta Fondatore e Padre - ha ammonito il Rettor gioia di Pasqua ha diffuso nei cuori! Maggiore, sig.
    [Show full text]