Hematologic Oncology Update — Issue 1, 2014

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POST-TEST Hematologic Oncology Update — issue 1, 2014 The c o rrec T answer is indicaTed wiTh yellow highlighTin g. 1. Which of the following is true regarding the 6. A Phase II study of single-agent brentux- CRS related to CAR T-cell therapy? imab vedotin for the treatment of relapsed a. It manifests as fever, nausea, myalgia or refractory CD30-positive non-hodgkin and hypotension lymphomas demonstrated promising antitumor b. It is associated with high levels of IL-6 activity in patients with DLBCL with a broad c. It is irreversible range of CD30 expression levels. d. Both a and b a. True b. False 2. Updated results of a pilot trial by Porter and colleagues of chimeric antigen receptor T-cell 7. Results from a Phase II trial comparing therapy for patients with relapsed/refractory consolidation therapy with a single dose of CLL reported an overall response rate of 90y-ibritumomab tiuxetan to rituximab mainte- _____________. nance for patients with newly diagnosed Fl a. 12% who have experienced a response to r-CHOP b. 57% demonstrated statistically significant differ- ences in _____________ favoring rituximab c. 82% maintenance. 3. Tocilizumab, an IL-6 receptor antagonist, is a. Progression-free survival effective at reversing the cytokine release b. Overall survival syndrome associated with chimeric antigen c. Both a and b receptor-modified T-cell therapy. a. True 8. The final stage II results of the Phase b. False III CLL11 trial for patients with CLL and coexisting medical conditions demon- 4. The results of a Phase III study of induction strated that obinutuzumab/chlorambucil was therapy with lenalidomide and dexametha- superior to rituximab/chlorambucil in terms of sone followed by maintenance lenalidomide _____________. for patients with high-risk sMM demonstrated a. Progression-free survival a statistically significant improvement in b. Overall response rate _____________ versus observation only. c. Both a and b a. Time to disease progression b. Three-year OS rate 9. Based on the results of a study by yilmaz c. Five-year OS rate and colleagues, long-term treatment with _____________ may result in a significant d. All of the above decline in the glomerular filtration rate in 5. The ongoing Phase III ECOG-e3a06 trial is patients with cMl. evaluating _____________ versus observation a. Dasatinib alone for patients with asymptomatic high-risk b. Imatinib sMM. c. Nilotinib a. Lenalidomide b. Lenalidomide in combination with 10. _____________ is an FDA-approved potent TKi low-dose dexamethasone for the treatment of chronic myeloid leukemia that was temporarily suspended because of a c. Lenalidomide in combination with high- risk of serious thrombosis and stenosis. dose dexamethasone a. Ponatinib b. Bosutinib c. Dasatinib d. Omacetaxine mepesuccinate e. All of the above.

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LEUKERAN 3 (Chlorambucil) 4 Tablets 5
1 PRESCRIBING INFORMATION ® 2 LEUKERAN 3 (chlorambucil) 4 Tablets 5 6 WARNING 7 LEUKERAN (chlorambucil) can severely suppress bone marrow function. Chlorambucil is a 8 carcinogen in humans. Chlorambucil is probably mutagenic and teratogenic in humans. 9 Chlorambucil produces human infertility (see WARNINGS and PRECAUTIONS). 10 DESCRIPTION 11 LEUKERAN (chlorambucil) was first synthesized by Everett et al. It is a bifunctional 12 alkylating agent of the nitrogen mustard type that has been found active against selected human 13 neoplastic diseases. Chlorambucil is known chemically as 4-[bis(2- 14 chlorethyl)amino]benzenebutanoic acid and has the following structural formula: 15 16 17 18 Chlorambucil hydrolyzes in water and has a pKa of 5.8. 19 LEUKERAN (chlorambucil) is available in tablet form for oral administration. Each 20 film-coated tablet contains 2 mg chlorambucil and the inactive ingredients colloidal silicon 21 dioxide, hypromellose, lactose (anhydrous), macrogol/PEG 400, microcrystalline cellulose, red 22 iron oxide, stearic acid, titanium dioxide, and yellow iron oxide. 23 CLINICAL PHARMACOLOGY 24 Chlorambucil is rapidly and completely absorbed from the gastrointestinal tract. After single 25 oral doses of 0.6 to 1.2 mg/kg, peak plasma chlorambucil levels (Cmax) are reached within 1 hour 26 and the terminal elimination half-life (t½) of the parent drug is estimated at 1.5 hours. 27 Chlorambucil undergoes rapid metabolism to phenylacetic acid mustard, the major metabolite, 28 and the combined chlorambucil and phenylacetic acid mustard urinary excretion is extremely 29 low — less than 1% in 24 hours. In a study of 12 patients given single oral doses of 0.2 mg/kg of 30 LEUKERAN, the mean dose (12 mg) adjusted (± SD) plasma chlorambucil Cmax was 31 492 ± 160 ng/mL, the AUC was 883 ± 329 ng●h/mL, t½ was 1.3 ± 0.5 hours, and the tmax was 32 0.83 ± 0.53 hours.
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