Mitochondrial Toxicity of Triclosan on Mammalian Cells
Toxicology Reports 2 (2015) 624–637 Contents lists available at ScienceDirect Toxicology Reports j ournal homepage: www.elsevier.com/locate/toxrep Mitochondrial toxicity of triclosan on mammalian cells a,∗,1 a,1 b,1 c Charmaine Ajao , Maria A. Andersson , Vera V. Teplova , Szabolcs Nagy , d e f g Carl G. Gahmberg , Leif C. Andersson , Maria Hautaniemi , Balazs Kakasi , h a Merja Roivainen , Mirja Salkinoja-Salonen a Department of Food and Environmental Sciences, Haartman Institute, University of Helsinki, POB 56, FI-00014, Finland b Institute of Theoretical and Experimental Biophysics, RAS, Puschino, Moscow Region, Russia c Department of Animal Science and Animal Husbandry, University of Pannonia, Georgikon Faculty, Deak F. u.,16, H8360 Keszthely, Hungary d Dept. of Bio- and Environmental Sciences, Haartman Institute, University of Helsinki, FI-00014, Finland e Dept. of Pathology, Haartman Institute, University of Helsinki, FI-00014, Finland f Finnish Food Safety Authority (EVIRA), Research and Laboratory Department, Veterinary Virology Research Unit, Mustialankatu 3, FI 00790 Helsinki, Finland g Institute of Environmental Sciences, University of Pannonia, Egyetem u. 10, H-8200 Veszprem, Hungary h National Institute for Health and Welfare, Department of Virology, Mannerheimintie 166, 00300 Helsinki, Finland a r t a b i c s t l r e i n f o a c t Article history: Effects of triclosan (5-chloro-2 -(2,4-dichlorophenoxy)phenol) on mammalian cells were Received 28 January 2015 investigated using human peripheral blood mono nuclear cells (PBMC), keratinocytes Received in revised form 29 March 2015 (HaCaT), porcine spermatozoa and kidney tubular epithelial cells (PK-15), murine pan- Accepted 30 March 2015 creatic islets (MIN-6) and neuroblastoma cells (MNA) as targets.
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