Bayesian Generalized Linear Models in R
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Statistical Methods for Data Science, Lecture 5 Interval Estimates; Comparing Systems
Statistical methods for Data Science, Lecture 5 Interval estimates; comparing systems Richard Johansson November 18, 2018 statistical inference: overview I estimate the value of some parameter (last lecture): I what is the error rate of my drug test? I determine some interval that is very likely to contain the true value of the parameter (today): I interval estimate for the error rate I test some hypothesis about the parameter (today): I is the error rate significantly different from 0.03? I are users significantly more satisfied with web page A than with web page B? -20pt “recipes” I in this lecture, we’ll look at a few “recipes” that you’ll use in the assignment I interval estimate for a proportion (“heads probability”) I comparing a proportion to a specified value I comparing two proportions I additionally, we’ll see the standard method to compute an interval estimate for the mean of a normal I I will also post some pointers to additional tests I remember to check that the preconditions are satisfied: what kind of experiment? what assumptions about the data? -20pt overview interval estimates significance testing for the accuracy comparing two classifiers p-value fishing -20pt interval estimates I if we get some estimate by ML, can we say something about how reliable that estimate is? I informally, an interval estimate for the parameter p is an interval I = [plow ; phigh] so that the true value of the parameter is “likely” to be contained in I I for instance: with 95% probability, the error rate of the spam filter is in the interval [0:05; 0:08] -20pt frequentists and Bayesians again. -
Generalized Linear Models (Glms)
San Jos´eState University Math 261A: Regression Theory & Methods Generalized Linear Models (GLMs) Dr. Guangliang Chen This lecture is based on the following textbook sections: • Chapter 13: 13.1 – 13.3 Outline of this presentation: • What is a GLM? • Logistic regression • Poisson regression Generalized Linear Models (GLMs) What is a GLM? In ordinary linear regression, we assume that the response is a linear function of the regressors plus Gaussian noise: 0 2 y = β0 + β1x1 + ··· + βkxk + ∼ N(x β, σ ) | {z } |{z} linear form x0β N(0,σ2) noise The model can be reformulate in terms of • distribution of the response: y | x ∼ N(µ, σ2), and • dependence of the mean on the predictors: µ = E(y | x) = x0β Dr. Guangliang Chen | Mathematics & Statistics, San Jos´e State University3/24 Generalized Linear Models (GLMs) beta=(1,2) 5 4 3 β0 + β1x b y 2 y 1 0 −1 0.0 0.2 0.4 0.6 0.8 1.0 x x Dr. Guangliang Chen | Mathematics & Statistics, San Jos´e State University4/24 Generalized Linear Models (GLMs) Generalized linear models (GLM) extend linear regression by allowing the response variable to have • a general distribution (with mean µ = E(y | x)) and • a mean that depends on the predictors through a link function g: That is, g(µ) = β0x or equivalently, µ = g−1(β0x) Dr. Guangliang Chen | Mathematics & Statistics, San Jos´e State University5/24 Generalized Linear Models (GLMs) In GLM, the response is typically assumed to have a distribution in the exponential family, which is a large class of probability distributions that have pdfs of the form f(x | θ) = a(x)b(θ) exp(c(θ) · T (x)), including • Normal - ordinary linear regression • Bernoulli - Logistic regression, modeling binary data • Binomial - Multinomial logistic regression, modeling general cate- gorical data • Poisson - Poisson regression, modeling count data • Exponential, Gamma - survival analysis Dr. -
Bayesian Inference Chapter 4: Regression and Hierarchical Models
Bayesian Inference Chapter 4: Regression and Hierarchical Models Conchi Aus´ınand Mike Wiper Department of Statistics Universidad Carlos III de Madrid Master in Business Administration and Quantitative Methods Master in Mathematical Engineering Conchi Aus´ınand Mike Wiper Regression and hierarchical models Masters Programmes 1 / 35 Objective AFM Smith Dennis Lindley We analyze the Bayesian approach to fitting normal and generalized linear models and introduce the Bayesian hierarchical modeling approach. Also, we study the modeling and forecasting of time series. Conchi Aus´ınand Mike Wiper Regression and hierarchical models Masters Programmes 2 / 35 Contents 1 Normal linear models 1.1. ANOVA model 1.2. Simple linear regression model 2 Generalized linear models 3 Hierarchical models 4 Dynamic models Conchi Aus´ınand Mike Wiper Regression and hierarchical models Masters Programmes 3 / 35 Normal linear models A normal linear model is of the following form: y = Xθ + ; 0 where y = (y1;:::; yn) is the observed data, X is a known n × k matrix, called 0 the design matrix, θ = (θ1; : : : ; θk ) is the parameter set and follows a multivariate normal distribution. Usually, it is assumed that: 1 ∼ N 0 ; I : k φ k A simple example of normal linear model is the simple linear regression model T 1 1 ::: 1 where X = and θ = (α; β)T . x1 x2 ::: xn Conchi Aus´ınand Mike Wiper Regression and hierarchical models Masters Programmes 4 / 35 Normal linear models Consider a normal linear model, y = Xθ + . A conjugate prior distribution is a normal-gamma distribution: -
Bayesian Methods: Review of Generalized Linear Models
Bayesian Methods: Review of Generalized Linear Models RYAN BAKKER University of Georgia ICPSR Day 2 Bayesian Methods: GLM [1] Likelihood and Maximum Likelihood Principles Likelihood theory is an important part of Bayesian inference: it is how the data enter the model. • The basis is Fisher’s principle: what value of the unknown parameter is “most likely” to have • generated the observed data. Example: flip a coin 10 times, get 5 heads. MLE for p is 0.5. • This is easily the most common and well-understood general estimation process. • Bayesian Methods: GLM [2] Starting details: • – Y is a n k design or observation matrix, θ is a k 1 unknown coefficient vector to be esti- × × mated, we want p(θ Y) (joint sampling distribution or posterior) from p(Y θ) (joint probabil- | | ity function). – Define the likelihood function: n L(θ Y) = p(Y θ) | i| i=1 Y which is no longer on the probability metric. – Our goal is the maximum likelihood value of θ: θˆ : L(θˆ Y) L(θ Y) θ Θ | ≥ | ∀ ∈ where Θ is the class of admissable values for θ. Bayesian Methods: GLM [3] Likelihood and Maximum Likelihood Principles (cont.) Its actually easier to work with the natural log of the likelihood function: • `(θ Y) = log L(θ Y) | | We also find it useful to work with the score function, the first derivative of the log likelihood func- • tion with respect to the parameters of interest: ∂ `˙(θ Y) = `(θ Y) | ∂θ | Setting `˙(θ Y) equal to zero and solving gives the MLE: θˆ, the “most likely” value of θ from the • | parameter space Θ treating the observed data as given. -
Generalized Linear Models
Generalized Linear Models A generalized linear model (GLM) consists of three parts. i) The first part is a random variable giving the conditional distribution of a response Yi given the values of a set of covariates Xij. In the original work on GLM’sby Nelder and Wedderburn (1972) this random variable was a member of an exponential family, but later work has extended beyond this class of random variables. ii) The second part is a linear predictor, i = + 1Xi1 + 2Xi2 + + ··· kXik . iii) The third part is a smooth and invertible link function g(.) which transforms the expected value of the response variable, i = E(Yi) , and is equal to the linear predictor: g(i) = i = + 1Xi1 + 2Xi2 + + kXik. ··· As shown in Tables 15.1 and 15.2, both the general linear model that we have studied extensively and the logistic regression model from Chapter 14 are special cases of this model. One property of members of the exponential family of distributions is that the conditional variance of the response is a function of its mean, (), and possibly a dispersion parameter . The expressions for the variance functions for common members of the exponential family are shown in Table 15.2. Also, for each distribution there is a so-called canonical link function, which simplifies some of the GLM calculations, which is also shown in Table 15.2. Estimation and Testing for GLMs Parameter estimation in GLMs is conducted by the method of maximum likelihood. As with logistic regression models from the last chapter, the generalization of the residual sums of squares from the general linear model is the residual deviance, Dm 2(log Ls log Lm), where Lm is the maximized likelihood for the model of interest, and Ls is the maximized likelihood for a saturated model, which has one parameter per observation and fits the data as well as possible. -
Heteroscedastic Errors
Heteroscedastic Errors ◮ Sometimes plots and/or tests show that the error variances 2 σi = Var(ǫi ) depend on i ◮ Several standard approaches to fixing the problem, depending on the nature of the dependence. ◮ Weighted Least Squares. ◮ Transformation of the response. ◮ Generalized Linear Models. Richard Lockhart STAT 350: Heteroscedastic Errors and GLIM Weighted Least Squares ◮ Suppose variances are known except for a constant factor. 2 2 ◮ That is, σi = σ /wi . ◮ Use weighted least squares. (See Chapter 10 in the text.) ◮ This usually arises realistically in the following situations: ◮ Yi is an average of ni measurements where you know ni . Then wi = ni . 2 ◮ Plots suggest that σi might be proportional to some power of 2 γ γ some covariate: σi = kxi . Then wi = xi− . Richard Lockhart STAT 350: Heteroscedastic Errors and GLIM Variances depending on (mean of) Y ◮ Two standard approaches are available: ◮ Older approach is transformation. ◮ Newer approach is use of generalized linear model; see STAT 402. Richard Lockhart STAT 350: Heteroscedastic Errors and GLIM Transformation ◮ Compute Yi∗ = g(Yi ) for some function g like logarithm or square root. ◮ Then regress Yi∗ on the covariates. ◮ This approach sometimes works for skewed response variables like income; ◮ after transformation we occasionally find the errors are more nearly normal, more homoscedastic and that the model is simpler. ◮ See page 130ff and check under transformations and Box-Cox in the index. Richard Lockhart STAT 350: Heteroscedastic Errors and GLIM Generalized Linear Models ◮ Transformation uses the model T E(g(Yi )) = xi β while generalized linear models use T g(E(Yi )) = xi β ◮ Generally latter approach offers more flexibility. -
Generalized Linear Models
CHAPTER 6 Generalized linear models 6.1 Introduction Generalized linear modeling is a framework for statistical analysis that includes linear and logistic regression as special cases. Linear regression directly predicts continuous data y from a linear predictor Xβ = β0 + X1β1 + + Xkβk.Logistic regression predicts Pr(y =1)forbinarydatafromalinearpredictorwithaninverse-··· logit transformation. A generalized linear model involves: 1. A data vector y =(y1,...,yn) 2. Predictors X and coefficients β,formingalinearpredictorXβ 1 3. A link function g,yieldingavectoroftransformeddataˆy = g− (Xβ)thatare used to model the data 4. A data distribution, p(y yˆ) | 5. Possibly other parameters, such as variances, overdispersions, and cutpoints, involved in the predictors, link function, and data distribution. The options in a generalized linear model are the transformation g and the data distribution p. In linear regression,thetransformationistheidentity(thatis,g(u) u)and • the data distribution is normal, with standard deviation σ estimated from≡ data. 1 1 In logistic regression,thetransformationistheinverse-logit,g− (u)=logit− (u) • (see Figure 5.2a on page 80) and the data distribution is defined by the proba- bility for binary data: Pr(y =1)=y ˆ. This chapter discusses several other classes of generalized linear model, which we list here for convenience: The Poisson model (Section 6.2) is used for count data; that is, where each • data point yi can equal 0, 1, 2, ....Theusualtransformationg used here is the logarithmic, so that g(u)=exp(u)transformsacontinuouslinearpredictorXiβ to a positivey ˆi.ThedatadistributionisPoisson. It is usually a good idea to add a parameter to this model to capture overdis- persion,thatis,variationinthedatabeyondwhatwouldbepredictedfromthe Poisson distribution alone. -
Generalized Linear Models
Generalized Linear Models Advanced Methods for Data Analysis (36-402/36-608) Spring 2014 1 Generalized linear models 1.1 Introduction: two regressions • So far we've seen two canonical settings for regression. Let X 2 Rp be a vector of predictors. In linear regression, we observe Y 2 R, and assume a linear model: T E(Y jX) = β X; for some coefficients β 2 Rp. In logistic regression, we observe Y 2 f0; 1g, and we assume a logistic model (Y = 1jX) log P = βT X: 1 − P(Y = 1jX) • What's the similarity here? Note that in the logistic regression setting, P(Y = 1jX) = E(Y jX). Therefore, in both settings, we are assuming that a transformation of the conditional expec- tation E(Y jX) is a linear function of X, i.e., T g E(Y jX) = β X; for some function g. In linear regression, this transformation was the identity transformation g(u) = u; in logistic regression, it was the logit transformation g(u) = log(u=(1 − u)) • Different transformations might be appropriate for different types of data. E.g., the identity transformation g(u) = u is not really appropriate for logistic regression (why?), and the logit transformation g(u) = log(u=(1 − u)) not appropriate for linear regression (why?), but each is appropriate in their own intended domain • For a third data type, it is entirely possible that transformation neither is really appropriate. What to do then? We think of another transformation g that is in fact appropriate, and this is the basic idea behind a generalized linear model 1.2 Generalized linear models • Given predictors X 2 Rp and an outcome Y , a generalized linear model is defined by three components: a random component, that specifies a distribution for Y jX; a systematic compo- nent, that relates a parameter η to the predictors X; and a link function, that connects the random and systematic components • The random component specifies a distribution for the outcome variable (conditional on X). -
Points for Discussion
Bayesian Analysis in Medicine EPIB-677 Points for Discussion 1. Precisely what information does a p-value provide? 2. What is the correct (and incorrect) way to interpret a confi- dence interval? 3. What is Bayes Theorem? How does it operate? 4. Summary of above three points: What exactly does one learn about a parameter of interest after having done a frequentist analysis? Bayesian analysis? 5. Example 8 from the book chapter by Jim Berger. 6. Example 13 from the book chapter by Jim Berger. 7. Example 17 from the book chapter by Jim Berger. 8. Examples where there is a choice between a binomial or a negative binomial likelihood, found in the paper by Berger and Berry. 9. Problems with specifying prior distributions. 10. In what types of epidemiology data analysis situations are Bayesian methods particularly useful? 11. What does decision analysis add to a Bayesian analysis? 1. Precisely what information does a p-value provide? Recall the definition of a p-value: The probability of observing a test statistic as extreme as or more extreme than the observed value, as- suming that the null hypothesis is true. 2. What is the correct (and incorrect) way to interpret a confi- dence interval? Does a 95% confidence interval provide a 95% probability region for the true parameter value? If not, what it the correct interpretation? In practice, it is usually helpful to consider the following graphic: Figure 1: How to interpret confidence intervals and/or credible regions. Depending on where the confidence/credible interval lies in relation to a region of clinical equivalence, different conclusions can be drawn. -
Generalized Linear Models Outperform Commonly Used Canonical Analysis in Estimating Spatial Structure of Presence/Absence Data
Generalized Linear Models outperform commonly used canonical analysis in estimating spatial structure of presence/absence data Lélis A. Carlos-Júnior1,2,3, Joel C. Creed4, Rob Marrs2, Rob J. Lewis5, Timothy P. Moulton4, Rafael Feijó-Lima1,6 and Matthew Spencer2 1 Programa de Pós-Graduacão¸ em Ecologia e Evolucão,¸ Universidade do Estado do Rio do Janeiro, Rio de Janeiro, Brazil 2 School of Environmental Sciences, University of Liverpool, Liverpool, United Kingdom 3 Departamento de Biologia, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil 4 Departamento de Ecologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil 5 Department of Forest Genetics and Biodiversity, Norwegian Institute of Bioeconomy Research, Bergen, Nor- way 6 Division of Biological Sciences, University of Montana, Missoula, MT, United States of America ABSTRACT Background. Ecological communities tend to be spatially structured due to environ- mental gradients and/or spatially contagious processes such as growth, dispersion and species interactions. Data transformation followed by usage of algorithms such as Redundancy Analysis (RDA) is a fairly common approach in studies searching for spatial structure in ecological communities, despite recent suggestions advocating the use of Generalized Linear Models (GLMs). Here, we compared the performance of GLMs and RDA in describing spatial structure in ecological community composition data. We simulated realistic presence/absence data typical of many β-diversity studies. For model selection we used standard methods commonly used in most studies involving RDA and GLMs. Submitted 19 November 2018 Methods. We simulated communities with known spatial structure, based on three Accepted 30 July 2020 real spatial community presence/absence datasets (one terrestrial, one marine and Published 3 September 2020 one freshwater). -
The Bayesian New Statistics: Hypothesis Testing, Estimation, Meta-Analysis, and Power Analysis from a Bayesian Perspective
Published online: 2017-Feb-08 Corrected proofs submitted: 2017-Jan-16 Accepted: 2016-Dec-16 Published version at http://dx.doi.org/10.3758/s13423-016-1221-4 Revision 2 submitted: 2016-Nov-15 View only at http://rdcu.be/o6hd Editor action 2: 2016-Oct-12 In Press, Psychonomic Bulletin & Review. Revision 1 submitted: 2016-Apr-16 Version of November 15, 2016. Editor action 1: 2015-Aug-23 Initial submission: 2015-May-13 The Bayesian New Statistics: Hypothesis testing, estimation, meta-analysis, and power analysis from a Bayesian perspective John K. Kruschke and Torrin M. Liddell Indiana University, Bloomington, USA In the practice of data analysis, there is a conceptual distinction between hypothesis testing, on the one hand, and estimation with quantified uncertainty, on the other hand. Among frequentists in psychology a shift of emphasis from hypothesis testing to estimation has been dubbed “the New Statistics” (Cumming, 2014). A second conceptual distinction is between frequentist methods and Bayesian methods. Our main goal in this article is to explain how Bayesian methods achieve the goals of the New Statistics better than frequentist methods. The article reviews frequentist and Bayesian approaches to hypothesis testing and to estimation with confidence or credible intervals. The article also describes Bayesian approaches to meta-analysis, randomized controlled trials, and power analysis. Keywords: Null hypothesis significance testing, Bayesian inference, Bayes factor, confidence interval, credible interval, highest density interval, region of practical equivalence, meta-analysis, power analysis, effect size, randomized controlled trial. he New Statistics emphasizes a shift of empha- phasis. Bayesian methods provide a coherent framework for sis away from null hypothesis significance testing hypothesis testing, so when null hypothesis testing is the crux T (NHST) to “estimation based on effect sizes, confi- of the research then Bayesian null hypothesis testing should dence intervals, and meta-analysis” (Cumming, 2014, p. -
More on Bayesian Methods: Part II
More on Bayesian Methods: Part II Rebecca C. Steorts Bayesian Methods and Modern Statistics: STA 360/601 Lecture 5 1 Today's menu I Confidence intervals I Credible Intervals I Example 2 Confidence intervals vs credible intervals A confidence interval for an unknown (fixed) parameter θ is an interval of numbers that we believe is likely to contain the true value of θ: Intervals are important because they provide us with an idea of how well we can estimate θ: 3 Confidence intervals vs credible intervals I A confidence interval is constructed to contain θ a percentage of the time, say 95%. I Suppose our confidence level is 95% and our interval is (L; U). Then we are 95% confident that the true value of θ is contained in (L; U) in the long run. I In the long run means that this would occur nearly 95% of the time if we repeated our study millions and millions of times. 4 Common Misconceptions in Statistical Inference I A confidence interval is a statement about θ (a population parameter). I It is not a statement about the sample. I It is also not a statement about individual subjects in the population. 5 Common Misconceptions in Statistical Inference I Let a 95% confidence interval for the average amount of television watched by Americans be (2.69, 6.04) hours. I This doesn't mean we can say that 95% of all Americans watch between 2.69 and 6.04 hours of television. I We also cannot say that 95% of Americans in the sample watch between 2.69 and 6.04 hours of television.