Encyclopedia of Cancer (2nd edition) MANFRED SCHWAB (Ed.)
Encyclopedia of Cancer (2nd edition)
With 979 Figures* and 210 Tables
*For color figures please see our Electronic Reference on www.springerlink.com Editor: Manfred Schwab Professor for Genetics Director Division of Tumour Genetics (B030) German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany
A C.I.P. Catalog record for this book is available from the Library of Congress
ISBN: 978-3-540-36847-2 This publication is available also as: Electronic publication under ISBN 978-3-540-47648-1 and Print and electronic bundle under ISBN 978-3-540-47649-8 Library of Congress Control Number 2008921484
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Printed on acid-free paper SPIN: 150231 2109 — 543210 Preface To The First Edition
Cancer, although a dreadful disease, is at the same time a fascinating biological phenotype. Around 1980, cancer was first attributed to malfunctioning genes and, subsequently, cancer research has become a major area of scientific research supporting the foundations of modern biology to a great extent. To unravel the human genome sequence was one of those extraordinary tasks, which has largely been fuelled by cancer research, and many of the fascinating insights into the genetic circuits that regulate developmental processes have also emerged from research on cancer. Diverse biological disciplines such as cytogenetics, virology, cell biology, classical and molecular genetics, epidemiology, biochemistry, together with the clinical sciences, have closed ranks in their search of how cancer develops and to find remedies to stop the abnormal growth that is characteristic of cancerous cells. In the attempt to establish how, why and when cancer occurs, a plethora of genetic pathways and regulatory circuits have been discovered that are necessary to maintain general cellular functions such as proliferation, differentiation and migration. Alterations of this fine-tuned network of cascades and interactions, due to endogenous failure or to exogenous challenges by environmental factors, may disable any member of such regulatory pathways. This could, for example, induce the death of the affected cell, may mark it for cancerous development or may immediately provide it with a growth advantage within a particular tissue.
Recent developments have seen the merger of basic and clinical science. Of the former, particularly genetics has provided instrumental and analytical tools with which to assess the role of environmental factors in cancer, to refine and enable diagnosis prior to the development of symptoms and to evaluate the prognosis of patients. Hopefully, even better strategies for causal therapy will become available in the future. Merging the basic and clinical science disciplines towards the common goal of fighting cancer, calls for a comprehensive reference source to serve both as a tool to close the language gap between clinical and basic science investigators and as an information platform for the student and the informed layperson alike. Obviously this was an extremely ambitious goal, and the immense progress in the field cannot always be portrayed in line with the latest developments. The aim of the Encyclopedia is to provide the reader with an entrance point to a particular topic. It should be of value to both basic and clinical scientists working in the field of cancer research. Additionally both students and lecturers in the life sciences should benefit highly from this database. I therefore hope that this Encyclopedia will become an essential complement to existing science resources.
The attempts to identify the mechanisms underlying cancer development and progression have produced a wealth of facts, and no single individual is capable of addressing the immense breadth of the field with undisputed authority. Hence, the ‘Encyclopedic Reference of Cancer’ is the work of many authors, all of whom are experts in their fields and reputable members of the international scientific community. Each author contributed a large number of keyword definitions and in-depth essays and in so doing it was possible to cover the broad field of cancer-related topics within a single publication. Obviously this approach entails a form of presentation, in which the author has the freedom to set priorities and to promote an individual point of view. This is most obvious when it comes to nomenclature, particularly that of genes and proteins. Although the editorial intention was to apply the nomenclature of the Human Genome Organisation (HUGO), the more vigorous execution of this attempt has been left to future endeavours.
In the early phase of planning the Encyclopedia, exploratory contacts to potential authors produced an overwhelmingly positive response. The subsequent contact with almost 300 contributory authors was a marvellous experience, and I am extremely grateful for their excellent and constructive cooperation. An important element in the preparation of the Encyclopedia has been the competent secretarial assistance of Hiltrud Wilbertz of the Springer-Verlag and of Ingrid Cederlund and Cornelia Kirchner of the DKFZ. With great attention to detail they helped to keep track of the technical aspects in the preparation of the manuscript. It was a pleasure to work with the Springer crew, including Dr. Rolf Lange as the Editorial Director (Medicine) and Dr. Thomas Mager, Senior Editor for Encyclopedias and Dictionaries. In particular I wish to thank Dr. Walter Reuss, who untiringly has mastered all aspects and problems associated with the management of the numerous manuscripts that were received from authors of the international scientific community. It has been satisfying and at times comforting to see how he made illustration files come alive. Thanks also to Dr. Claudia Lange who, being herself a knowledgeable cell biologist, has worked as the scientific editor. Her commitment and interest have substantially improved this Encyclopedia. vi Preface To The First Edition
As a final word, I would like to stress that although substantial efforts have been made to compose factually correct and well understandable presentations, there may be places where a definition is incomplete or a phrase in an essay is flawed. All contributors to this Encyclopedia will be extremely happy to receive possible corrections, or revisions, in order for them to be included in any future editions of the ‘Encyclopedic Reference of Cancer’.
Heidelberg, September 2001 MANFRED SCHWAB Preface To The Second Edition
Given the overwhelming success of the First Edition of the Cancer Encyclopedia, which appeared in 2001, and the amazing development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition, following the principle concept of the first edition that has proven so successful.
Recent developments are seeing a dynamic merging of basic and clinical science, with translational research increasingly becoming a new paradigm in cancer research. The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for advanced students and informed laymen alike. It is intended to be a resource for all interested in information beyond their specific own expertise.
While the First Edition had featured contributions from approximately 300 scientists/clinicians in one Volume, the Second Edition includes more than 1000 contributors in 4 Volumes with an A–Z format of more than 7000 entries. It provides definitions of common acronyms and short definitions of both related terms and processes in the form of keyword entries. A major information source are detailed essays that provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between entries. Essays represent original contributions by the corresponding authors, all distinguished scientists in their own field, Editorial input has been carefully restricted to formal aspects.
A panel of Field Editors, each an eminent international expert for the corresponding field, has served to ensure the presentation of timely and authoritative Encyclopedia entries. These new traits are likely to meet the expectance that a wide community has towards a cancer reference works.
An important element in the preparation of the Encyclopedia has been the competent support by the Springer crew, Dr. Michaela Bilic, Saskia Ellis and, lately, Jana Simniok. I am extremely grateful for their excellent and pleasant cooperation.
The Cancer Encyclopedia, Second Edition, will be accessible both in print and online versions. Clinicians, research scientists and advanced students will find this an amazing resource and a highly informative reference to cancer.
Heidelberg, March 15, 2008 MANFRED SCHWAB Editor in Chief
Manfred Schwab Tumor Genetics German Cancer Research Center, DKFZ Heidelberg Germany [email protected] Field Editors
STEFAN BARTH Houston, TX Department of Pharmaceutical Product USA Development, Fraunhofer-Institute [email protected] for Molecular Biology and Applied Ecology JOSEPH R. LANDOLPH Aachen Departments of Molecular Microbiology and Germany Immunology, and Pathology; USC/Norris [email protected] Comprehensive Cancer Center, Keck School of Medicine; Department of Molecular Pharmacology and Pharmaceutical Sciences, School of Pharmacy PAOLO BOFFETTA Health Sciences Campus Lifestyle, Environment and Cancer Group University of Southern California International Agency for Research on Cancer Los Angeles, CA Lyon USA France [email protected] [email protected] HENRY LYNCH GRAHAM A. COLDITZ Preventive Medicine and Public Health Washington University in St. Louis Hereditary Cancer Institute St. Louis, MO Creighton University USA Omaha, NE [email protected] USA [email protected]
ROY J. DUHÉ PAUL G. MURRAY Department of Pharmacology and Toxicology CRUK Institute for Cancer Studies University of Mississippi Medical Center The Medical School Jackson, MS University of Birmingham USA Birmingham [email protected] UK [email protected]
KENT HUNTER SAUL SUSTER Metastasis Susceptibility Section The Ohio State University Laboratory of Cancer Biology & Genetics Columbus, OH CCR/NCI/NIH USA Bethesda, MD [email protected] USA [email protected] ANDREW THORBURN University of Colorado at Denver and Health JESPER JURLANDER Sciences Center Department of Hematology and the Leukemia Aurora, CO Laboratory USA Rigshospitalet [email protected] Copenhagen Denmark MARTIN TOBI [email protected] University of Pennsylvania School of Medicine Chief GI Section Philadelphia VAMC RAKESH KUMAR Philadelphia, PA Molecular and Cellular Oncology USA The University of Texas MD Anderson Cancer Center [email protected] List of Contributors xiii
List of Contributors
VESA AALTONEN FARRUKH AFAQ Department of Anatomy Department of Dermatology Institute of Biomedicine University of Wisconsin University of Turku Medical Sciences Center Turku Madison, WI Finland USA [email protected] [email protected]
CORY ABATE-SHEN CHAPLA AGARWAL Center for Advanced Biotechnology and Medicine Department of Pharmaceutical Sciences, School of Pharmacy UMDMJ – Robert Wood Johnson Medical School University of Colorado Health Sciences Center Piscataway, NJ Denver, CO USA USA [email protected] [email protected]
RAJESH AGARWAL PHILLIP H. ABBOSH Department of Pharmaceutical Sciences, School of Pharmacy Department of Pathology and Laboratory Medicine University of Colorado Health Sciences Center Indiana University School of Medicine Denver, CO Indianapolis, IN USA USA [email protected] [email protected]
PATRIZIA AGOSTINIS FRITZ ABERGER Catholic University of Leuven Department of Molecular Biology Leuven University of Salzburg Belgium Salzburg, Austria [email protected] [email protected] TERJE AHLQUIST HINRICH ABKEN Department of Cancer Prevention Tumor Genetics, Clinic I Internal Medicine and Center for Rikshospitalet-Radiumhospitalet Medical Centre Molecular Medicine Cologne, University of Cologne Oslo Cologne, Germany Norway [email protected] [email protected]
AMAL M. ABU-GHOSH SHAHID AHMED Departments of Pediatric Hematology and Oncology Saskatoon Cancer Center Lombardi Comprehensive Cancer Center University of Saskatchewan Georgetown University Saskatoon, SK Washington DC, NW Canada USA [email protected] [email protected] JOOHONG AHNN Department of Life Science ROSITA ACCARDI Gwangju Institute of Science and Technology Infections and Cancer Biology Group Buk-Gu, Gwangju International Agency for Research on Cancer Korea Lyon [email protected] France [email protected] CEM AKIN University of Michigan FILIPPO ACCONCIA Ann Arbor, MI Molecular and Cellular Oncology USA The University of Texas M. D. Anderson Cancer Center [email protected] Houston, TX USA ENRIQUE DE ALAVA IFOM Centro de Investigación del Cáncer-IBMCC The FIRC Institute for Molecular Oncology Salamanca Milan Spain Italy [email protected] xiv List of Contributors
AMI ALBIHN GIANFRANCO ALPINI Department of Microbiology Departments of Medicine and Systems Biology and Tumor and Cell Biology (MTC) Translational Medicine, Central Texas Veterans Health Care Karolinska Institutet System, Scott & White Hospital and Texas A&M Stockholm University System Health Science Center Sweden Temple TX [email protected] USA [email protected] ADRIANA ALBINI IRCCS Multimedica Milano MARIE-CLOTILDE ALVES-GUERRA Italy The Wistar Institute [email protected] Molecular and Cellular Oncogenesis Program Philadelphia, PA JÉRÔME ALEXANDRE USA Faculté de Médecine Paris – Descartes [email protected] UPRES 18-33, Groupe Hospitalier Cochin – Saint Vincent de Paul Paris PIERRE ÅMAN France LLCR, Department of pathology, Institute of Biomedicine [email protected] Sahlgrenska Academy Goteborg University Gothenburg SHADAN ALI Sweden Karmanos Cancer Institute [email protected] Wayne State University Detroit, MI USA KUROSH AMERI [email protected] University of Stanford School of Medicine Department of Surgery/Surgical Oncology MALCOLM R. ALISON Stanford, CA Centre for Diabetes and Metabolic Medicine USA Queen Mary’s School of Medicine and Dentistry [email protected] Institute of Cell and Molecular Science London MOUNIRA AMOR-GUÉRET UK – [email protected] Institut Curie UMR 2027 CNRS Orsay Cedex France CATHERINE ALIX-PANABIERES [email protected] University Medical Center, Lapeyronie Hospital Montpellier France KENNETH C. ANDERSON [email protected] Department of Medical Oncology The Jerome Lipper Multiple Myeloma Center ALISON L. ALLAN Dana-Farber Cancer Institute Cancer Research Laboratories, London Regional Cancer Harward Medical School Program; and Departments of Oncology and Anatomy and Boston, MA Cell Biology, Schulich School of Medicine and Dentistry USA University of Western Ontario, [email protected] London, ON Canada [email protected] PETER ANGEL Deutsches Krebsforschungszentrum Division of Signal Transduction and Growth Control PAOLA ALLAVENA Heidelberg Department of Immunology Germany Fondazione Humanitas per la Ricerca [email protected] Rozzano, Milan Italy [email protected] ANDREA ANICHINI Department of Experimental Oncology ANGEL ALONSO Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura Deutsches Krebsforschungszentrum dei Tumori Heidelberg Milan Germany Italy [email protected] [email protected] List of Contributors xv
PETER D. APLAN ELIAS S. J. ARNÉR Genetics Branch, Center for Cancer Research Department of Medical Biochemistry and Biophysics National Cancer Institute, National Institutes of Health Karolinska Institutet Bethesda, MD Stockholm USA Sweden [email protected] [email protected]
NATALIA APTSIAURI STEFANO ATERINI Hospital Universitario Virgen de las Nieves Department of Experimental Pathology and Oncology Granada University of Firenze Spain Firenze [email protected] Italy [email protected]
RAMI AQEILAN MARC AUMERCIER Molecular Virology, Immunology and Medical Genetics Institute of Biology of Lille, Pasteur Institute of Lille The Ohio State University, Comprehensive Cancer Center Universities of Lille 1 and Lille 2 Columbus, OH Lille USA France [email protected] [email protected]
TSUTOMU ARAKI RICCARDO AUTORINO Departments of Obstetrics and Gynecology Clinica Urologica Nippon Medical School Seconda Università degli Studi Kawasaki and Tokyo Napoli Japan Italy [email protected] [email protected]
SANCHIA ARANDA MATIAS A. AVILA School of Nursing Division of Hepatology and Gene Therapy, CIMA The University of Melbourne University of Navarra Carlton, VIC Pamplona Australia Spain [email protected] [email protected]
DIEGO ARANGO HAVA AVRAHAM Molecular Biology and Biochemistry Research Center Division of Experimental Medicine (CIBBIM) Beth Israel Deaconess Medical Center Valle Hebron Hospital Research Institute Harvard Institutes of Medicine Barcelona Boston, MA Spain USA [email protected] [email protected]
SHALOM AVRAHAM DAVID J. ARATEN Division of Experimental Medicine NYU School of Medicine Beth Israel Deaconess Medical Center, Harvard Institutes NYU Cancer Institute, and the New York VA Medical Center of Medicine New York, NY Boston, MA USA USA [email protected] [email protected]
VALENTINA ARCANGELI SANJAY AWASTHI Department of Oncology United States Longview Cancer Center Infermi Hospital Longview, TX Rimini USA Italy [email protected] [email protected]
YOGESH C. AWASTHI GEMMA ARMENGOL Department of Human Biological Chemistry and Genetics Department of Pathology University of Texas Medical Branch Vall d’Hebron University Hospital Galveston, TX Barcelona, Spain USA [email protected] [email protected] xvi List of Contributors
MATHIJS BAENS LAURENT BALENCI Centre for Human Genetics, Molecular Genetics-Flanders INSERM Unité Mixte 873 Interuniversity Institute for Biotechnology Grenoble Cedex 09 University of Leuven France Leuven [email protected] Belgium [email protected] SUSHANTA K. BANERJEE Division of Hematology and Oncology, School of Medicine DEBASIS BAGCHI Kansas University of Medical Center Department of Pharmacy Sciences Kansas City, KS Creighton University Medical Center USA Omaha, NE [email protected] USA [email protected] MICHAL BANIYASH XUE-TAO BAI The Lautenberg Center for General and Tumor Immunology State Key Laboratory for Medical Genomics, Shanghai The Hebrew University-Hadassah Medical School Institute of Hematology, Ruijin Hospital Jerusalem School of Medicine Shanghai Jiao Tong University Israel Shanghai, People's Republic of China [email protected] [email protected]
RACHEL BAR-SHAVIT JÜRGEN BAJORATH Department of Oncology Department of Life Science Informatics Hadassah-University Hospital B-IT University of Bonn, Bonn Jerusalem Germany Israel [email protected] [email protected]
ADITYA BARDIA STUART G. BAKER Biometry Research Group Department of Internal Medicine National Cancer Institute Mayo Clinic College of Medicine Bethesda, MD Rochester, MN USA USA [email protected] [email protected]
ELIZABETH K. BALCER-KUBICZEK RAFIJUL BARI Department of Radiation Oncology Vascular Biology Center, Cancer Institute, and Departments University of Maryland School of Medicine of Medicine and Molecular Sciences Baltimore, MD University of Tennessee Health Science Center USA Memphis, TN [email protected] USA [email protected]
ENKE BALDINI Department of Experimental Medicine DR NICOLA L. P. BARNES “ ” University of Rome Sapienza Department of Academic Surgery Rome South Manchester University Hospital Italy Manchester [email protected] UK
GRAHAM S. BALDWIN Department of Surgery ROBERT BAROUKI University of Melbourne INSERM UMR-S 747, Université René Descartes Paris Austin Health Paris, France Melbourne, VIC [email protected] Australia [email protected] JM BARROS-DIOS Department of Preventive Medicine and Public Health SHERRI BALE University of Santiago de Compostela GeneDx, Rockville, MD C/San Francisco USA Spain [email protected] [email protected] List of Contributors xvii
HARRY BARTELINK PAIGE J. BAUGHER Department of Radiotherapy Department of Cancer Biology The Netherlands Cancer Institute–Antoni van Leeuwenhoek Vanderbilt University Medical School Hospital Nashville, TN Amsterdam USA The Netherlands [email protected] [email protected] ASNE R. BAUSKIN STEFAN BARTH Centre for Immunology, St. Vincents Hospital and Department of Pharmaceutical Product Development Department of Medicine Fraunhofer-Institute for Molecular University of New South Wales Biology and Applied Ecology Sydney, NSW Aachen Australia Germany [email protected] [email protected] NICOLE BEAUCHEMIN McGill Cancer Centre HELMUT BARTSCH McGill University Division of Toxicology and Cancer Risk Factors Montreal, Quebec German Cancer Research Center (DKFZ) Canada Heidelberg [email protected] Germany [email protected] JOHN F. BECHBERGER Department of Cellular and Physiological Sciences THOMAS BARZ The University of British Columbia Max-Panck-Institut für Psychiatrie Vancouver, BC München Canada Germany [email protected] [email protected]
GERHILD BECKER HOLGER BASTIANS Department of Internal Medicine II (Gastroenterology, Philipps University Marburg Hepatology, Endocrinology) Institute for Molecular Biology and Tumor Research (IMT) University Hospital Freiburg Marburg Freiburg, Germany Germany [email protected] [email protected] HEINZ BECKER A. BATISTATOU Department of General and Visceral Surgery Ioannina University Medical School University Medical Center Ioannina Göttingen Greece Germany [email protected] [email protected]
MARIE E. BECKNER F. BATTEUX Department of Pathology Faculté de Médecine Paris – Descartes University of Pittsburgh School of Medicine UPRES 18-33, Groupe Hospitalier Cochin – Saint Vincent de Pittsburgh, PA Paul USA Paris [email protected] France [email protected] CLAUS BELKA Department of Radiation Oncology JACQUES BAUDIER University Tübingen INSERM Unité Mixte 873 Tübingen Grenoble Cedex 09 Germany France [email protected] [email protected]
MAURIZIO BENDANDI PAUL BAUER University Clinic and Center for Applied Medical Research Pfizer Research Technology Center University of Navarra Cambridge, MA Pamplona USA Spain [email protected] [email protected] xviii List of Contributors
YAACOV BEN-DAVID SANCHITA BHADRA Division of Cancer Biology, Sunny brook Health Sciences Section of Molecular Genetics and Microbiology and Institute University of Toronto for Cellular and Molecular Biology Toronto, ONT The University of Texas at Austin Canada Austin, TX [email protected] USA [email protected]
SUZANNE M. BENJES Cancer Genetics Research Group, University of Otago at KUMAR M. R. BHAT Christchurch Department of Dermatology Christchurch, New Zealand University of Wisconsin School of Medicine and Public [email protected] Health Sciences Madison, WI USA CARMEN BERASAIN Division of Hepatology and Gene Therapy, CIMA [email protected] University of Navarra Pamplona MALAYA BHATTACHARYA-CHATTERJEE Spain University of Cincinnati and The Barrett Cancer Center [email protected] Cincinnatti, OH USA [email protected] ALAN BEREZOV Department of Pathology and Laboratory Medicine & Abramson Cancer Center CATERINA BIANCO University of Pennsylvania Mammary Biology and Tumorigenesis Laboratory Philadelphia, PA National Cancer Institute, National Institutes of Health USA Bethesda, MD [email protected] USA [email protected]
ROB J. W. BERG University Medical Center Utrecht JEAN-MICHEL BIDART Utrecht Institut de Cancérologie Gustave-Roussy The Netherlands Villejuif and Université Paris-Sud 11, Paris [email protected] France [email protected]
CORINNA BERGELT Institute of Medical Psychology JACLYN A. BIEGEL University Medical Center Hamburg-Eppendorf The Children’s Hospital of Philadelphia Hamburg Philadelphia, PA Germany USA [email protected] [email protected]
RENE BERNARDS MARGHERITA BIGNAMI The Netherlands Cancer Institute Istituto Superiore di Sanita’ Amsterdam Rome The Netherlands Italy [email protected] [email protected]
ZWI BERNEMAN IRENE V. B IJNSDORP Laboratory of Experimental Hematology Department of Medical Oncology Antwerp University Hospital VU University Medical Center Edegem Amsterdam Belgium The Netherlands [email protected] [email protected]
JÉRÔME BERTHERAT CHEN BING Assistance Publique Hôpitaux de Paris, Hôpital Cochin Division of Cellular and Metabolic Medicine, Department of Endocrinology School of Clinical Sciences Reference Center for Rare Adrenal Diseases University of Liverpool Paris Liverpool France UK [email protected] [email protected] List of Contributors xix
MARC BIRKHAHN PAOLO BOFFETTA Departments of Urology and Pathology Gene-Environment Epidemiology Group University of Southern California Keck School of Medicine International Agency for Research on Cancer Los Angeles, CA Lyon USA France [email protected] [email protected]
STEFAN K. BOHLANDER GIOVANNI BLANDINO Medizinische Klinik und Poliklinik III, Klinikum Großhadern Rome Oncogenomic Center, Department of Experimental Universität München Oncology München Regina Elena Cancer Institute Germany Rome [email protected] Italy [email protected] VALENTINA BOLLATI Department of Occupational and Environmental Health “ ” DAVID E. BLASK Clinica del Lavoro L. Devoto Bassett Research Institute University of Milan The Mary Imogene Bassett Hospital Milan Cooperstown, NY Italy USA [email protected] [email protected] MARIA GRAZIA BORRELLO Department of Experimental Oncology JONATHAN BLAY IRCCS Istituto Nazionale Tumori Foundation Department of Pharmacology Milan Dalhousie University Italy Halifax, NS [email protected] Canada [email protected] GIUSEPPE BORZACCHIELLO Department of Pathology and Animal health University of Naples Federico II ADRIAN J. BLOOR Naples The Christie NHS Trust Italy Manchester [email protected] UK [email protected] VALERIE BOSCH Forschungsschwerpunkt Infektion und Krebs, F020 JULIAN BLOW German Cancer Research Center (DKFZ) Wellcome Trust Biocentre Heidelberg University of Dundee Germany Dundee, Scotland [email protected] UK [email protected] CHRIS BOSHOFF Cancer Research Campaign Viral Oncology Group Wolfson Institute for Biomedical Research PETER BLUME-JENSEN University College London Serono Reproductive Biological Institute London Randolph, MA UK USA [email protected]
FRANCK BOURDEAUT SARAH BOCCHINI Department of Experimental Medicine Département de pédiatrie University of Rome “Sapienza” INSERM 830, Biologie et génétique des tumeurs Rome Institut Curie Italy Paris [email protected] France [email protected]
ANN M. BODE JEAN-PIERRE BOURQUIN The Hormel Institute Pediatric Oncology University of Minnesota University Children’s Hospital Zurich Austin, MN Zurich USA Switzerland [email protected] [email protected] xx List of Contributors
JUDITH V. M. G. B OVÉE KATJA BROCKE-HEIDRICH Department of Pathology Institute of Clinical Immunology and Transfusion medicine Leiden University Medical Center University Hospital of Leipzig Leiden Leipzig The Netherlands Germany J.V.M.G. [email protected] [email protected]
NORMAN BOYD ANGELA BRODIE Campbell Family Institute for Breast Cancer Research University of Maryland School of Medicine Ontario Cancer Institute Baltimore, MD Toronto, ONT USA Canada University of Maryland Greenebaum Cancer Center [email protected] Baltimore, MD USA SVEN BRANDAU [email protected] Department of Otorhinolaryngology University Duisburg-Essen CHRISTOPHER L. BROOKS Essen Institute for Cancer Genetics, and Department of Pathology Germany College of Physicians and Surgeons, Columbia University [email protected] New York, NY USA BURKHARD H. BRANDT Institute for Tumour Biology University Medical Centre MAI N. BROOKS Hamburg Surgical Oncology, School of Medicine Germany University of California [email protected] Los Angeles, CA USA [email protected] HILTRUD BRAUCH Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology DAVID A. BROWN and University Tuebingen Centre for Immunology, St. Vincents Hospital and Stuttgart Department of Medicine Germany University of New South Wales [email protected] Sydney, NSW Australia [email protected] SAMUEL N. BREIT Centre for Immunology, St. Vincents Hospital and Department of Medicine KAREN BROWN University of New South Wales Cancer Biomarkers and Prevention Group Sydney, NSW Department of Cancer Studies, University of Leicester Australia Leicester [email protected] UK [email protected] EDWIN BREMER Groningen University Institute for Drug Exploration KEVIN BROWN (GUIDE), Department of Pathology & Laboratory Medicine University of Florida College of Medicine Section Medical Biology, Laboratory for Tumor Immunology Gainesville, FL Groningen USA The Netherlands [email protected] [email protected] DIEDERIK DE BRUIJN CATHERINE BRENNER Department of Human Genetics University of Versailles/SQY Radboud University Nijmegen Medical Centre CNRS UMR 8159, Versailles Nijmegen France The Netherlands [email protected] [email protected]
DAV ID J. BRENNER TILMAN BRUMMER Department of Radiation Oncology Cancer Research Program Columbia University Garvan Institute of Medical Research New York, NY Sydney, NSW USA Australia [email protected] [email protected] List of Contributors xxi
ANTONIO BRUNETTI NEVILLE J. BUTCHER Department of Experimental and Clinical Medicine School of Biomedical Sciences G. Salvatore University of Queensland University of Catanzaro Magna Græcia St Lucia, QLD Catanzaro Australia Italy [email protected] [email protected] TIMON P. H. B UYS ANDREAS K. BUCK Department of Cancer Genetics and Developmental Biology Department of Nuclear Medicine British Columbia Cancer Research Centre Technical University of Munich Vancouver, BC Munich Canada Germany [email protected] [email protected]
YI CAI LASZLO BUDAY Department of Pathology Department of Medical Chemistry Baylor College of Medicine Semmelweis University Medical School Houston, TX Budapest USA Hungary [email protected] YIQIANG CAI Section of Nephrology MARIE ANNICK BUENDIA Yale University School of Medicine Oncogenesis and Molecular Virology Unit New Haven, CT Inserm U579 USA Institut Pasteur, Paris [email protected] France [email protected] BRUNO CALABRETTA Thomas Jefferson University RALF BUETTNER Kimmel Cancer Institute City of Hope National Medical Center and Beckman Philadelphia, PA Research Institute USA Duarte, CA [email protected] USA [email protected] DANIELE CALISTRI Molecular Laboratory NIGEL J. BUNDRED Department of Academic Surgery Istituto Scientifico Romagnolo per lo Studio e la Cura dei South Manchester University Hospital Tumori Manchester Meldola (Forlì) UK Italy [email protected] [email protected]
IRINA BUß JAVIER CAMACHO Institute of Pharmacy Pharmacology Division University of Bonn Centro de Investigación y de Estudios Avanzados del I.P.N. Bonn Mexico City, Mexico Germany [email protected] [email protected] WILLIAM G. CANCE ALEXANDER BÜRKLE Departments of Surgery Department of Biology University of Florida College of Medicine University of Konstanz Gainesville, FL Konstanz USA Germany [email protected] [email protected] AMPARO CANO JADISH BUTANY Departamento de Bioquímica Laboratory Medicine and Pathobiology Facultad de Medicina, UAM, Instituto de Investigaciones University Health Network/Toronto Biomédicas “Alberto Sols” CSIC-UAM Toronto, ON Madrid Canada Spain [email protected] [email protected] xxii List of Contributors
SHARON CANTOR ESTEBAN CELIS Assistant Professor of Cancer Biology H. Lee Moffitt Cancer Center and Research Institute UMASS Medical School University of South Florida Worcester, MA Tampa, FL USA USA [email protected] [email protected]
ANTHONY J. CAPOBIANCO HO MAN CHAN The Wistar Institute Division of Biochemistry and Molecular Biology Molecular and Cellular Oncogenesis Program University of Glasgow Philadelphia, PA Glasgow USA UK [email protected] DAWN S. CHANDLER ’ SALVATORE J. CARADONNA Department of Pediatrics, Columbus Children s Research University of Medicine and Dentistry of New Jersey Institute, Center for Childhood Cancer Stratford, NJ The Ohio State University School of Medicine and Public USA Health [email protected] Columbus, OH USA [email protected] MICHELE CARBONE Cancer Research Center of Hawaii University of Hawaii MAU-SUN CHANG Honolulu, HI Department of Medical Research USA Mackay Memorial Hospital [email protected] Taipei County 251 Taiwan [email protected] NEIL OCARRAGHER Advanced Science and Technology Laboratory MEI-CHI CHANG AstraZeneca R&D Charnwood Biomedical Science Team Loughborough Chang Gung Institute of Technology UK Taoyuan [email protected] Taiwan [email protected] MICHELA CASANOVA Pediatric Oncology Unit JANE C.-J. CHAO Fondazione IRCCS Istituto Nazionale Tumori School of Nutrition and Health Sciences Milano Taipei Medical University Italy Taipei [email protected] Taiwan [email protected] WOLFGANG H. CASELMANN Medizinische Klinik und Poliklinik I CHRISTINE CHAPONNIER Rheinische Friedrich-Wilhelms-Universität Department of Pathology and Immunology Bonn University of Geneva Germany Geneva [email protected] Switzerland [email protected] ROBERTO CATTANEO Molecular Medicine Program and Virology and Gene KONSTANTINOS CHARALABOPOULOS Therapy Track Ioannina University Medical School Mayo Clinic College of Medicine Ioannina Rochester, MN Greece USA [email protected] [email protected]
MALAY CHATTERJEE WEBSTER K. CAVENEE Department of Pharmaceutical Technology Ludwig Institute for Cancer Research, UCSD Jadavpur University La Jolla, CA Calcutta, West Bengal USA India [email protected] [email protected] List of Contributors xxiii
SUNIL K. CHATTERJEE JIN Q. CHENG University of Cincinnati and The Barrett Cancer Center Molecular Oncology and Pathology, Cincinnatti, OH H. Lee Moffitt Cancer Center & Research Institute USA University of South Florida College of Medicine [email protected] Tampa, FL USA GAUTAM CHAUDHURI [email protected] Department of Molecular and Medical Pharmacology and Department of Obstetrics and Gynecology LIANG CHENG David Geffen School of Medicine at UCLA Department of Pathology and Laboratory Medicine Los Angeles, CA Indiana University School of Medicine USA Indianapolis, IN [email protected] USA [email protected]
M. ASIF CHAUDRY YA-HUI CHI University Department of Surgery National Institute of Allergy and Infectious Disease, NIH Royal Free and University College London Medical School Bethesda, MD London USA UK [email protected] [email protected] MARTYN A. CHIDGEY DHARMINDER CHAUHAN Division of Medical Sciences Department of Medical Oncology University of Birmingham The Jerome Lipper Multiple Myeloma Center Clinical Research Block Dana Farber Cancer Institute Queen Elizabeth Hospital Harvard Medical School Birmingham Boston, MA UK USA [email protected] [email protected] YOUNG-WON CHIN College of Pharmacy JEREMY P. C HEADLE The Ohio State University Institute of Medical Genetics Columbus, OH Cardiff University USA Heath Park, Cardiff [email protected] UK [email protected] SUDHAKAR CHINTHARLAPALLI Department of Veterinary Physiology and Pharmacology SAI-JUAN CHEN Texas A&M University State Key Laboratory for Medical Genomics, Shanghai College Station, TX Institute of Hematology, Ruijin Hospital USA School of Medicine Shanghai Jiao Tong University [email protected] Shanghai, People's Republic of China [email protected] ALEXANDRE CHLENSKI The Robert H. Lurie Comprehensive Cancer Center TAOSHENG CHEN Northwestern University New Leads, Bristol-Myers Squibb Feinberg School of Medicine Wallingford, CT Chicago, IL USA USA [email protected] [email protected]
WILLIAM CHI-SHING CHO ZHU CHEN Department of Clinical Oncology State Key Laboratory for Medical Genomics, Shanghai Queen Elizabeth Hospital Institute of Hematology, Ruijin Hospital Kowloon School of Medicine Shanghai Jiao Tong University Hong Kong Shanghai, People's Republic of China [email protected] [email protected] MICHAEL CHOPP GEORGE Z. CHENG Neurology Research Mount Sinai School of Medicine Henry Ford Health System New York, NY Detroit, MI USA USA [email protected] [email protected] xxiv List of Contributors
PEI-LUN CHOU PIER PAOLO CLAUDIO Division of Allergy-Immunology-Rheumatology, Department of Surgery Department of Internal Medicine Marshall University Lin Shin Hospital Huntington, WV Taichung USA Taiwan [email protected]
CLAUS CHRISTENSEN ELIZABETH B. CLAUS Department of Cancer Genetics Department of Epidemiology and Public Health Danish Cancer Society Yale University School of Medicine Copenhagen New Haven, CT Denmark USA [email protected] [email protected]
RIKKE CHRISTENSEN PASCAL CLAYETTE Anatomy and Neurobiology, Institute of Medical Biology SPI-BIO, Service de Neurovirologie, CEA, CRSSA, EPHE University of Southern Denmark Fontenay aux Roses Cedex Odense, Denmark France [email protected] [email protected]
GERHARD CHRISTOFORI Department of Clinical-Biological Sciences, Centre of STEVEN C. CLIFFORD Biomedicine Northern Institute for Cancer Research Institute of Biochemistry and Genetics, University of Basel Newcastle University Basel Newcastle upon Tyne Switzerland UK [email protected] [email protected]
RICHARD I. CHRISTOPHERSON KEVIN A. COCKELL School of Molecular and Microbial Biosciences Nutrition Research Division University of Sydney Health Canada Sydney, NSW Ottawa, ON Australia Canada [email protected] [email protected]
BONG HYUN CHUNG SUSAN L. COHN BioNanotechnology Research Center Clinical Sciences Korea Research Institute of Bioscience and Biotechnology The Institute for Molecular Pediatric Sciences Yuseong, Daejeon University of Chicago Republic of Korea Chicago, IL [email protected] USA [email protected] FUNG-LUNG CHUNG Department of Oncology, Lombardi Comprehensive Cancer GRAHAM A. COLDITZ Center Washington University in St. Louis Georgetown University Medical Center St. Louis, MO Washington, DC USA USA [email protected] [email protected]
JACKY K. H. CHUNG PAOLA COLLINI Department of Medical Genetics and Microbiology Anatomic Pathology Department University of Toronto Fondazione IRCCS Istituto Nazionale Tumori Toronto, Ontario Milano Canada Italy [email protected] [email protected]
SUE CLARK ANDREW R. COLLINS The Polyposis Registry Department of Nutrition St Mark’s Hospital University of Oslo Harrow Oslo UK Norway [email protected] [email protected] List of Contributors xxv
JOAN W. CONAWAY SIDNEY CROUL Stowers Institute for Medical Research Department of Pathology, UHN Kansas, MO University of Toronto USA ON [email protected] Canada [email protected]
RONALD C. CONAWAY Stowers Institute for Medical Research VINCENT L. CRYNS Kansas, MO Department of Medicine, Feinberg School of Medicine USA Northwesten University [email protected] Chicago, IL USA [email protected] NATHALIE COOLS Laboratory of Experimental Hematology RONALD G. CRYSTAL Antwerp University Hospital Department of Genetic Medicine Edegem Weill Medical College of Cornell University Belgium New York, NY [email protected] USA [email protected] HELEN C. COONEY UCD School of Biomolecular and Biomedical Science JIUWEI CUI UCD Conway Institute Department of Medical Biophysics University College Dublin University of Toronto Dublin Toronto, ONT Ireland Canada [email protected] [email protected]
EDNA CUKIERMAN KUMARASEN COOPER Basic Science/Tumor Cell Biology Department of Pathology Fox Chase Cancer Center University of Vermont Philadelphia, PA Burlington, VT USA USA [email protected] [email protected]
ZORAN CULIG LAURENCE J. N. COOPER Department of Urology Division of Pediatrics, Department of Immunology Innsbruck Medical University M.D. Anderson Cancer Center Innsbruck Houston, TX Austria USA [email protected] [email protected] DAVID T. CURIEL PETER J. COOPMAN Departments of Medicine, Pathology, Surgery, Obstetrics and CRBM/CNRS UMR 5237, Univ Gynecology and the Gene Therapy Center, Division of Montpellier II, Montpellier Human Gene Therapy France University of Alabama at Birmingham [email protected] Birmingham, AL USA [email protected] RICHARD J. COTE Departments of Urology and Pathology YATARO DAIGO University of Southern California Keck School of Medicine Institute of Medical Science Los Angeles, CA The University of Tokyo USA Tokyo [email protected] Japan [email protected] MARCUS V. C RONAUER Institute of General Zoology and Endocrinology ANGUS G. DALGLEISH University of Ulm St. George’s Hospital Medical School Ulm London Germany UK [email protected] [email protected] xxvi List of Contributors
ASHRAF DALLOL KAUSTUBH DATTA Department of Medical and Molecular Genetics, Institute of Department of Urology Research, Department of Biomedical Research Biochemistry and Molecular Biology University of Birmingham Mayo Clinic College of Medicine Birmingham Rochester, Minnesota UK USA [email protected] [email protected]
TAMAS DALMAY School of Biological Sciences PRAN K. DATTA University of East Anglia Departments of Surgery and Cancer Biology Norwich Vanderbilt-Ingram Cancer Center, Vanderbilt University UK School of Medicine [email protected] Nashville, TN USA IVAN DAMJANOV [email protected] Department of Pathology University of Kansas School of Medicine LEONOR DAV I D Kansas City, KS IPATIMUP (Institute of Molecular Pathology and USA Immunology of the University of Porto) and Medical Faculty [email protected] of the University of Porto Porto VINCENT DAMMAI Portugal Hollings Cancer Center and Department of Pathology and [email protected] Laboratory Medicine Medical University of South Carolina Charleston, SC HELEN DAV I S USA Oxford University [email protected] Medical School John Radcliffe Hospital CHENDIL DAMODARAN Oxford Department of Clinical Sciences UK University of Kentucky [email protected] Lexington, Kentucky USA [email protected] ALEXEY DAVYDOV Fox Chase Cancer Center JANET E. DANCEY Philadelphia, PA Division of Cancer Treatment and Diagnosis USA National Cancer Institute [email protected] Rockville, MD USA [email protected] ROBERT DAY Department of Pharmacology, Institut de Pharmacologie Faculté de Médecine CHI V. D ANG Sidney Kimmel Comprehensive Cancer Center at Université de Sherbrooke Johns Hopkins Sherbrooke, QC Johns Hopkins University School of Medicine Canada Baltimore, MD [email protected] USA [email protected] JOCHEN DECKER Bioscientia Institute Center for Human Genetics ALLA DANILKOVITCH-MIAGKOVA and University of Mainz National Cancer Institute-FCRDC Ingelheim Frederick, MD Germany USA [email protected] [email protected]
MASSIMINO D’ARMIENTO AMIR R. DEHDASHTI Department of Experimental Medicine Division of Neurosurgery University of Rome-Sapienza University of Toronto Rome Toronto, ON Italy Canada [email protected] [email protected] List of Contributors xxvii
MARYSE DELEHEDDE MARC DIEDERICH INSERM U774 Laboratoire de Biologie Moléculaire et Cellulaire du Cancer Institut Pasteur de Lille (LBMCC) Lille Hôpital Kirchberg France Steichen [email protected] Luxembourg [email protected]
BERNA DEMIRCAN JOSEPH DIFRANZA University of Florida College of Medicine Department of Family Medicine and Community Health Gainesville, FL University of Massachusetts Medical Center USA Worcester, MA [email protected] USA [email protected] DAVID A. DENNING Department of Surgery MARTIN DIGWEED Marshall University Institute of Human Genetics Huntington, WV Charité – Universitätsmedizin Berlin USA Berlin [email protected] Germany [email protected]
SYLVIANE DENNLER PETER TEN DIJKE The Netherlands Cancer Institute The Netherlands Cancer Institute Amsterdam Amsterdam The Netherlands The Netherlands [email protected] [email protected]
CHANNING J. DER GERARD DIJKSTRA University of North Carolina at Chapel Hill University Medical Center Groningen Chapel Hill, NC University of Groningen USA Groningen [email protected] The Netherlands [email protected]
BARBARA DESCHLER HELEN DIMARAS Medical Center, Department of Hematology-Oncology Ontario Cancer Institute/Princess Margaret Hospital University of Freiburg Toronto, ON Freiburg Canada Germany [email protected] [email protected]
JIAN DING CHANTAL DESDOUETS State Key Laboratory of Drug Research, Shanghai Institute of Institut Cochin Materia Medica, Shanghai Institutes for Biological Sciences Université Paris Descartes, CNRS Chinese Academy of Sciences Paris Shanghai France P. R. China [email protected] [email protected]
JÜRGEN DITTMER PETER DEVILEE Clinic for Gynecology Leiden University Medical Center University of Halle, Halle Leiden Germany The Netherlands [email protected] [email protected]
HENRIK J. DITZEL MARK W. DEWHIRST Medical Biotechnology Center Department of Radiation Oncology Institute of Medical Biology Duke University University of Southern Denmark Durham, NC Odense C USA Denmark [email protected] [email protected] xxviii List of Contributors
CHOLPON S. DJUZENOVA BRIAN J. DRUKER Klinik für Strahlentherapie der Universität Würzburg Oregon Health & Science University Cancer Institute Würzburg Portland, OR Germany USA [email protected] [email protected]
CHRISTIAN DOEHN RAYMOND N. DUBOIS Department of Urology Provost and Executive Vice President University of Luebeck, Medical School M.D. Anderson Cancer Center Luebeck Houston, TX Germany USA [email protected] [email protected]
YASUFUMI DOI DAN G. DUDA Department of Environmental Medicine Steele Laboratory for Tumor Biology Graduate School of Medical Sciences Department of Radiation Oncology Kyushu University Massachusetts General Hospital and Harvard Medical School Fukuoka Boston, MA Japan USA [email protected] [email protected]
QIHAN DONG JAQUELIN P. D UDLEY Central Clinical School Section of Molecular Genetics and Microbiology and Institute The University of Sydney, Department of Endocrinology and for Cellular and Molecular Biology Sydney Cancer Centre, Royal Prince Alfred Hospital The University of Texas at Austin NSW Austin, TX Australia USA [email protected] [email protected]
ZIGANG DONG ROY J. DUHÉ The Hormel Institute Department of Pharmacology and Toxicology University of Minnesota University of Mississippi Medical Center Austin, MN Jackson, MS USA USA [email protected] [email protected]
Q. PING DOU IGNACIO DURAN The Prevention Program, Barbara Ann Karmanos Cancer Department of Medical Oncology and Hematology Institute and Department of Pathology, School of Medicine Robert and Maggie Bras and Family New Drug Development Wayne State University Program Detroit, MI Princess Margaret Hospital USA Toronto, ONT [email protected] Canada [email protected] TOMMASO A. DRAGANI Fondazione IRCCS Istituto Nazionale Tumori STEPHEN T. DURANT Milan University of Oxford Italy Oxford [email protected] UK [email protected] KENNETH DRAKE Department of Chemistry and Biochemistry MEENAKSHI DWIVEDI University of Texas at Arlington Department of Life Science Arlington, TX Gwangju Institute of Science and Technology USA Buk-Gu, Gwangju [email protected] Korea [email protected] MARTIN DREYLING Department of Internal Medicine III BEHFAR EHDAIE University of Munich, Großhadern University of Virginia München Charlottesville, VA Germany USA [email protected] [email protected] List of Contributors xxix
JUSTIS P. E HLERS ANDREAS ENGERT Department of Ophthalmology and Visual Sciences Hematology and Oncology Washington University School of Medicine University Hospital of Cologne, Department of Internal St. Louis, MO Medicine I USA Cologne [email protected] Germany [email protected] C. H. J. VA N EIJCK Department of Surgery COCAV A. ENGMAN Erasmus MC Department of Medicine Rotterdam Dartmouth Hitchcock Medical Center The Netherlands Lebanon, NH [email protected] USA [email protected] GERHARD EISENBRAND Department of Chemistry, Division of Food Chemistry and MARICA EOLI Toxicology Unit of Clinical Neuro-Oncology University of Kaiserslautern Istituto Neurologico Besta Kaiserslautern Milano Germany Italy [email protected]
PATRICIA V. E LIZALDE SÜLEYMAN ERGÜN Institute of Biology and Experimental Medicine (IBYME) Institute of Anatomy CONICET University Hospital Essen Buenos Aires Essen Argentina Germany [email protected] [email protected]
BASSEL F. EL-RAYES PABLO V. E SCRIBÁ Karmanos Cancer Institute Department of Biology-IUNICS Wayne State University University of the Balearic Islands Detroit, MI Palma de Mallorca USA Spain [email protected] [email protected]
MITSURU EMI FRANCISCO J. ESTEVA Departments of Obstetrics and Gynecology Breast Cancer Translational Research Laboratory Nippon Medical School The University of Texas MD Anderson Cancer Center Kawasaki and Tokyo Houston, TX Japan USA [email protected] [email protected]
CAROLINE END MARK F. EVANS Division of Molecular Genome Analysis, DKFZ Department of Pathology Heidelberg University of Vermont Germany Burlington, VT [email protected] USA [email protected] MANON VAN ENGELAND Department of Pathology Research Institute for Growth and Development (GROW) B. MARK EVERS Maastricht University Hospital Department of Surgery, Maastricht University of Texas Medical Branch The Netherlands Galveston, TX [email protected] USA [email protected]
RAINER ENGERS Institute of Pathology CRISTINA MARIA FAILLA University Hospital Düsseldorf Laboratory of Molecular and Cell Biology, IDI-IRCCS Düsseldorf Rome Germany Italy [email protected] [email protected] xxx List of Contributors
MARCO FALASCA ANDREW P. F EINBERG Department of Medicine Department of Medicine and Center for Epigenetics University College London Institute for Basic Biomedical Sciences London Johns Hopkins University School of Medicine UK Baltimore, MD [email protected] USA [email protected]
FANG FAN Department of Pathology MARK A. FEITELSON University of Kansas School of Medicine Department of Pathology, Anatomy and Cell Biology Kansas City, KS Thomas Jefferson University USA Philadelphia, PA [email protected] USA [email protected]
SAIJUN FAN DAVID FELDMAN Long Island Jewish Medical Center Division of Endocrinology Albert Einstein College of Medicine Department of Medicine, Stanford University School of Bronx, NY Medicine USA Stanford, CA USA BINGLIANG FANG [email protected] Department of Thoracic and Cardiovascular Surgery The University of Texas M. D. Anderson Cancer Center FRANCESCO FEO Houston, TX Department of Biomedical Sciences USA Division of Experimental Pathology and Oncology [email protected] Sassari Italy [email protected] LEI FANG Dermatology Branch MARIE FERNET National Cancer Institute, National Institutes of Health INSERM U612, Institut Curie-Recherche Bethesda, MD Orsay USA France [email protected] [email protected]
VALERIA R. FANTIN ANDREA FERRARI Merck Research Laboratories Pediatric Oncology Unit Boston, MA Fondazione IRCCS Istituto Nazionale Tumori USA Milano [email protected] Italy [email protected]
OMID C. FAROKHZAD Laboratory of Nanomedicine and Biomaterials, Department LORENA L. FIGUEIREDO-PONTES of Anesthesiology Medical School of Ribeirão Preto Brigham and Women’s Hospital University of São Paulo Boston, MA Ribeirão Preto USA Brazil [email protected] [email protected]
DANIEL FINLEY WILLIAM L. FARRAR – Department of Cell Biology National Cancer Institute Frederick Harvard Medical School Frederick, MD Boston, MA USA USA [email protected] [email protected]
ALESSANDRO FATATIS GAETANO FINOCCHIARO Department of Pharmacology and Physiology Istituto Nazionale Neurologico Besta Drexel University College of Medicine Unit of Experimental Neuro-Oncology Philadelphia, PA Milano USA Italy [email protected] [email protected] List of Contributors xxxi
PIER PAOLO DI FIORE RICCARDO FODDE IFOM, the FIRC Institute of Molecular Oncology Department of Pathology Milan Josephine Nefkens Institute Italy Erasmus MC, Rotterdam [email protected] The Netherlands [email protected] PAUL B. FISHER Departments of Urology, Pathology and Neurosurgery JUDAH FOLKMAN Columbia University Medical Center Children’s Hospital and Harvard Medical School College of Physicians and Surgeons Boston, MA New York, NY USA USA [email protected] [email protected]
HAMIDREZA FONOUNI JAMES FLANAGAN Department of General Wolfson Institute for Biomedical Research Visceral and Transplantation Surgery University College London University of Heidelberg London Heidelberg UK Germany [email protected] [email protected]
MICHAEL FLEISCHHACKER KENNETH A. FOON Charité-Universitätsmedizin Berlin The Pittsburgh Cancer Institute CCM, Berlin Pittsburgh, PA Germany USA [email protected] [email protected]
ELIEZER FLESCHER ALESSANDRA FORNI Department of Human Microbiology, Sackler Faculty of EPOCA Epidemiology Research Center, “Clinica del Lavoro Medicine L. Devoto” Tel Aviv University University of Milan Tel Aviv Milan Israel Italy [email protected] [email protected]
JONATHAN A. FLETCHER Albany Medical College PAUL FOSTER Albany Department of Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine NY ’ [email protected] St. Mary s Hospital London UK BARBARA D. FLORENTINE [email protected] Department of Pathology Henry Mayo Newhall Memorial Hospital Valencia, CA and Keck School of Medicine, University of DAVID A. FRANK Southern California, Los Angeles, CA Dana-Farber Cancer Institute and Harvard Medical School USA Boston, MA [email protected] USA [email protected]
ROKA FLORIAN Department of Surgical Oncology STUART J. FRANK The University of Texas M. D. Anderson Cancer Center Division of Endocrinology, Diabetes, and Metabolism, Houston, TX Department of Medicine USA University of Alabama at Birmingham [email protected] Birmingham, AL USA [email protected] TAMARA FLOYD Cancer Vaccine Branch, National Cancer Institute, National Institutes of Health STANLEY R. FRANKEL Bethesda, MD Merck Research Laboratories USA Upper Gwynedd, PA [email protected] USA xxxii List of Contributors
ALEKSANDRA FRANOVIC ATSUKO FUJIHARA Department of Cellular and Molecular Medicine Department of Gene Therapy Science Faculty of Medicine, University of Ottawa Osaka University, Graduate School of Medicine Ottawa, ONT Suita, Osaka Canada Japan [email protected] [email protected]
MICHAEL R. FREEMAN JIRO FUJIMOTO Urological Diseases Research Center Department of Obstetrics and Gynecology Children’s Hospital Boston, Harvard Medical School Gifu University School of Medicine Boston, MA Gifu City USA Japan [email protected] [email protected]
JUN FUJITA EMIL FREI III Department of Clinical Molecular Biology, Graduate School Dana-Farber Cancer Institute of Medicine Boston, MA Kyoto University USA Kyoto [email protected] Japan [email protected] JEAN-NOËL FREUND INSERM, U682 KENJI FUKASAWA Université Louis Pasteur Molecular Oncology Program Strasbourg H. Lee Mofitl Cancer Center & Research Institute France Tampa, FL [email protected] USA [email protected] ERROL C. FRIEDBERG University of Texas Southwestern Medical Center SIMONE FULDA Dallas, TX University Children’s Hospital, University of Ulm USA Ulm [email protected] Germany [email protected]
STEVEN M. FRISCH Mary Babb Randolph Cancer Center and Department of KYLE FURGE Biochemistry Van Andel Research Institute West Virginia University Grand Rapids, MI Morgantown, WV USA USA [email protected] [email protected] MUTSUO FURIHATA Department of Pathology PAUL FRÉNEAUX Kochi Medical School Département de Pathologie Kochi Institut Curie Japan Paris [email protected] France [email protected] RHOIKOS FURTWÄNGLER Division of Pediatric Hematology and Oncology MICHAEL C. FRÜHWALD Saarland University Hospital Department of Pediatric Hematology and Oncology Homburg/Saar University Children’s Hospital Muenster Germany Muenster [email protected] Germany [email protected] BERNARD W. FUTSCHER Department of Pharmacology and Toxicology, Arizona ANDREW M. FRY Cancer Center and College of Pharmacy University of Leicester University of Arizona Leicester Tucson, AZ UK USA [email protected] [email protected] List of Contributors xxxiii
SHIRISH GADGEEL ANDREI L. GARTEL Karmanos Cancer Institute Department of Medicine Wayne State University University of Illinois at Chicago Detroit, MI Chicago, IL USA USA [email protected] [email protected]
FEDERICO GAGO RONALD B. GARTENHAUS Departamento de Farmacología The University of Maryland Marlene and Stewart Universidad de Alcalá Greenebaum Cancer Center Alcalá de Henares, Madrid Baltimore, MD Spain USA [email protected] [email protected]
WILLIAM M. GALLAGHER THOMAS A. GASIEWICZ UCD School of Biomolecular and Biomedical Science University of Rochester Medical Center UCD Conway Institute Rocheser, NY University College Dublin USA Dublin [email protected] Ireland [email protected] PATRIZIA GASPARINI Molecular-Cytogenetic Unit, Department of Experimental Oncology BERNARD GALLEZ Biomedical Magnetic Resonance Istituto Nazionale Tumori Université Catholique de Louvain Milano Brussels Italy Belgium [email protected] [email protected] GRÉGORY GATOUILLAT Laboratory of Biochemistry BRENDA L. GALLIE IFR53, Faculty of Pharmacy Ontario Cancer Institute/Princess Margaret Hospital Reims cedex, France Toronto, ON [email protected] Canada [email protected] ADI F. GAZDAR Hamon Center for therapeutic Oncology Research and PING GAO Departments of Pathology, Internal Medicine and Division of Hematology, Department of Medicine Pharmacology Johns Hopkins University School of Medicine University of Texas Southwestern Medical Center Baltimore, MD Dallas, Texas USA USA [email protected] [email protected]
ROY GARCIA CHRISTIAN GEISLER City of Hope National Medical Center and Beckman The Leukemia and Lymphoma Marker Laboratory Research Institute Department of Hematology, The Finsen Centre Duarte, CA Rigshospitalet, Copenhagen USA Denmark [email protected] [email protected]
LAWRENCE B. GARDNER SPYROS D. GEORGATOS The NYU Cancer Institute Department of Basic Sciences New York University School of Medicine The University of Crete, School of Medicine New York, NY Heraklion, Crete USA Greece [email protected] [email protected]
CATHIE GARNIS JULIA M. GEORGE MIT Center for Cancer Research Department of Molecular and Integrative Physiology Cambridge, MA University of Illinois at Urbana-Champaign USA IL, USA [email protected] [email protected] xxxiv List of Contributors
ARMIN GERGER MICHAEL K. GIBSON Department of Internal Medicine, Division of Oncology University of Pittsburgh Cancer Institute Medical University Graz Pittsburgh, PA Graz USA Austria [email protected] [email protected]
ULRICH GERMING MICHAEL Z. GILCREASE Klinik für Hämatologie Department of Pathology, Breast Section Onkologie und Klinische Immunologie M. D. Anderson Cancer Center Heinrich-Heine-Universität Houston, TX Düsseldorf USA Germany [email protected] [email protected]
M.B. GILLESPIE JEFFREY E. GERSHENWALD Head and Neck Tumor Program Department of Surgical Oncology Hollings Cancer Center The University of Texas M. D. Anderson Cancer Center Medical University of South Carolina Houston, TX Charleston, SC USA USA [email protected]
ANDREAS J. GESCHER FRANÇOIS NOËL GILLY Cancer Biomarkers and Prevention Group Department of Digestive Oncologic Surgery Department of Cancer Studies, University of Leicester Hospices Civils de Lyon–Université Lyon 1 Leicester Lyon UK France [email protected] [email protected]
CHRISTIAN GESPACH INSERM U. 673, Paris, France; Laboratory of Molecular and THOMAS D. GILMORE Clinical Oncology of Solid tumors, Faculté de Médecine Biology Department, Boston University Université Pierre et Marie Curie-Paris 6 Boston, MA Paris USA France [email protected] [email protected]
B. MICHAEL GHADIMI OLIVER GIMM Department of General and Visceral Surgery Department of Surgery University Medical Center University Hospital Göttingen Linköping Germany Sweden [email protected] [email protected]
RICCARDO GHIDONI LUTZ GISSMANN Laboratory of Biochemistry and Molecular Biology DKFZ, Heidelberg San Paolo Medical School Germany University of Milan [email protected] Milan Italy [email protected] MORTEN F. GJERSTORFF Department of Oncology RONALD A. GHOSSEIN Odense University Hospital Department of Pathology Odense C Memorial Sloan-Kettering Cancer Center Denmark New York, NY [email protected] USA [email protected] SHANNON S. GLASER LORENZO GIANNI Departments of Medicine and Research and Education Department of Oncology Scott & White Hospital and Texas A&M Infermi Hospital University System Health Science Center Rimini Temple, TX Italy USA [email protected] [email protected] List of Contributors xxxv
HANSRUEDI GLATT SUSANNE M. GOLLIN German Institute of Human Nutrition (DIfE) Department of Human Genetics Potsdam-Rehbruecke University of Pittsburgh Graduate School of Public Health Nuthetal Pittsburgh, PA Germany USA [email protected] [email protected]
OLIVIER GLEHEN ROY M. GOLSTEYN Department of Digestive Oncologic Surgery Senior Scientist, Cancer Research Division Hospices Civils de Lyon–Université Lyon 1 Institut de Recherches Servier Lyon Croissy-Sur-Seine France France [email protected] [email protected]
ALEKSANDRA GLOGOWSKA ELLEN L. GOODE Department of Human Anatomy and Cell Science Mayo Clinic College of Medicine University of Manitoba Rochester, MN Winnipeg, MB USA Canada [email protected]
THOMAS W. GLOVER GREGORY J. GORES Department of Human Genetics Miles and Shirley Fiterman Center for Digestive Diseases University of Michigan Division of Gastroenterology and Hepatology Ann Arbor, MI Mayo Clinic College of Medicine USA Rochester, MN [email protected] USA [email protected] ULRICH GÖBEL Clinic of Pediatric Oncology TOBIAS GÖRGE Hematology and Immunology Department of Dermatology Heinrich-Heine-University Düsseldorf University of Münster Düsseldorf Münster Germany Germany [email protected] [email protected]
J. GODDARD NORIKO GOTOH Head and Neck Tumor Program Institute of Medical Sciences Hollings Cancer Center The University of Tokyo Medical University of South Carolina Minatoku, Tokyo Charleston, SC Japan USA [email protected] [email protected] STEPHANIE GOUT ANDREW K. GODWIN Le Centre de recherche en cancérologie de l’Université Laval Department of Medical Oncology Québec, QC Fox Chase Cancer Center Canada Philadelphia, PA [email protected] USA [email protected] AMMI GRAHN Department of Clinical Chemistry and Transfusion Medicin GARY S. GOLDBERG Institute of Biomedicine Molecular Biology Sahlgrenska academy at Göteborg University University of Medicine and Dentistry of New Jersey Göteborg Stratford, NJ Sweden USA [email protected] [email protected] PETER GREAVES ITZHAK D. GOLDBERG Department of Cancer Studies and Molecular Medicine Long Island Jewish Medical Center University of Leicester Albert Einstein College of Medicine Leicester Bronx, NY UK USA [email protected] xxxvi List of Contributors
MARK I. GREENE VALENTINA GUARNERI Department of Pathology and Laboratory Medicine & Department of Oncology and Hematology Abramson Cancer Center University of Modena and Reggio Emilia, Policlinico University of Pennsylvania via del Pozzo, Modena Philadelphia, PA Italy USA [email protected] [email protected] WEI GU W. M. U. VA N GREVENSTEIN Institute for Cancer Genetics, and Department of Pathology Department of Surgery College of Physicians and Surgeons, Columbia University Erasmus MC New York, NY Rotterdam USA The Netherlands [email protected] [email protected] LILIANA GUEDEZ ARJAN W. GRIFFIOEN Extracellular Matrix Pathology Section, Cell and Cancer Angiogenesis Laboratory, Department of Pathology Biology Branch Maastricht University National Cancer Institute Maastricht Bethesda, MD The Netherlands USA [email protected] [email protected]
DIRK GRIMM F. PETER GUENGERICH University of Heidelberg, Cluster of Excellence Cell Department of Biochemistry and Center in Molecular Networks Toxicology BIOQUANT Vanderbilt University School of Medicin Heidelberg, Nashville, TN Germany USA [email protected] [email protected]
MATTHEW J. GRIMSHAW ABHIJIT GUHA Breast Cancer Biology Group, King’s College London School Division of Neurosurgery of Medicine, Guy’s Hospital University of Toronto London ON UK Canada [email protected] [email protected]
STEPHEN R. GROBMYER Department of Surgery, Division of Surgical Oncology KATHERINE A. GUINDON Department of Pharmacology and Toxicology University of Florida ’ Gainesville, FL Queen s University USA Kingston, ONT [email protected] Canada [email protected] BERND GROSCHE Department of Radiation Protection and Health ERICH GULBINS Bundesamt für Strahlenschutz (Federal Office for Radiation Department of Molecular Biology Protection) University of Duisburg-Essen Oberschleissheim Essen Germany Germany [email protected] [email protected]
HANS H. GRUNICKE BILL GULLICK Biocenter, Division of Medical Biochemistry Department of Biosciences Medical University of Innsbruck University of Kent at Canterbury Innsbruck Canterbury, Kent Austria UK [email protected] [email protected]
JULIANA GUARIZE URSULA GÜNTHERT Department of Thoracic Surgery Department of Clinical and Biological Sciences European Institute of Oncology Institute for Medical Microbiology, University of Basel Milan Basel Italy Switzerland [email protected] [email protected] List of Contributors xxxvii
JAMES F. GUSELLA PIERRE HAINAUT Molecular Neurogenetics Unit Group of Molecular Carcinogenesis and Biomarkers Massachusetts General Hospital International Agency for Research on Cancer Charlestown, MA World Health Organization USA Lyon cedex 08 [email protected] France [email protected]
GRAEME R. GUY Signal Transduction Laboratory BRETT M. HALL Department of Pediatrics Institute of Molecular and Cell Biology ’ Singapore Columbus Children s Research Institute [email protected] The Ohio State University Columbus, OH USA MANUEL GUZMÁN [email protected] Department of Biochemistry and Molecular Biology I School of Biology JANET HALL Complutense University INSERM U612, Institut Curie-Recherche Madrid Orsay Spain France [email protected] [email protected]
GEUM-YOUN GWAK JOYCE L. HAMLIN Department of Medicine Department of Biochemistry and Molecular Genetics Samsung Medical Center University of Virginia School of Medicine Sungkyunkwan University School of Medicine Charlottesville, VA Gangnam-gu, Seoul USA South Korea [email protected] [email protected] RASHA S. HAMOUDA National Institutes of Health CLAUDIA HAFERLACH Bethesda, MD MLL Munich Leukemia Laboratory USA, Munich [email protected] Germany [email protected] J. WILLIAM HARBOUR Department of Ophthalmology and Visual Sciences TORSTEN HAFERLACH Washington University School of Medicine MLL Munich Leukemia Laboratory St. Louis, MO Munich USA Germany [email protected] [email protected] MARK HARLAND STEPHAN A. HAHN Section of Epidemiology and Biostatistics University of Bochum Cancer Research UK Clinical Centre, Leeds Institute of Bochum Molecular Medicine, St. James’s University Hospital Germany Leeds [email protected] UK [email protected]
JÖRG HAIER ADRIAN L. HARRIS Department of General Surgery University of Oxford, Cancer Research UK University Hospital Münster Weatherall Institute of Molecular Medicine, John Radcliffe Münster Hospital Germany Headington, Oxford [email protected] UK [email protected] NUMSEN HAIL Department of Pharmaceutical Sciences UZMA HASAN The University of Colorado at Denver and Health Sciences Infections and Cancer Biology Group Center International Agency for Research on Cancer Denver, CO Lyon USA France [email protected] [email protected] xxxviii List of Contributors
MIA HASHIBE OLAF HEIDENREICH Gene-Environment Epidemiology Group Northern Institute for Cancer Research International Agency for Research on Cancer Newcastle University Lyon Newcastle upon Tyne France UK [email protected] [email protected]
MASAHARU HATA DAVID G. HEIDT Department of Radiology Department of Surgery Yokohama City University, Graduate School of Medicine University of Michigan Medical Center Yokohama, Kanagawa Ann Arbor, MI Japan USA [email protected]
WERNER HELD JOHN.D.HAYES Ludwig Institute for Cancer Research Biomedical Research Centre, Ninewells Hospital and Lausanne Branch, and University of Lausanne Medical School Epalinges University of Dundee Switzerland Dundee, Scotland [email protected] UK [email protected] CARL-HENRIK HELDIN Ludwig Institute for Cancer Research LILI HE Uppsala Molecular Oncology and Pathology Sweden H. Lee Moffitt Cancer Center & Research Institute [email protected] Tampa, FL USA [email protected] WIJNAND HELFRICH Groningen University Institute for Drug Exploration (GUIDE), Department of Pathology & Laboratory Medicine, LI-ZHEN HE Section Medical Biology, Laboratory for Tumor Immunology Memorial Sloan-Kettering Cancer Center Groningen Weill Cornell Graduate School of Medical Sciences The Netherlands NY [email protected] USA [email protected] DEBBY HELLEBREKERS Department of Pathology RUTH HE Georgetown University Research Institute for Growth and Development (GROW) Lombardi Comprehensive Cancer Center Maastricht University Hospital Washington, DC Maastricht USA The Netherlands [email protected] [email protected]
STEPHEN S. HECHT PAUL W. S. HENG The Cancer Center Department of Pharmacy University of Minnesota National University of Singapore Minneapolis, MN Singapore USA Singapore [email protected] [email protected]
AHMED E. HEGAB KAI-OLIVER HENRICH Department of Geriatric and Respiratory Medicine DKFZ, German Cancer Research Center Tohoku University Hospital Heidelberg Sendai Germany Japan [email protected] [email protected] MARIE HENRIKSSON AXEL HEIDENREICH Department of Microbiology Division of Oncological Urology, Department of Urology Tumor and Cell Biology (MTC) University of Köln Karolinska Institutet Köln Stockholm Germany Sweden [email protected] [email protected] List of Contributors xxxix
ELIZABETH PETRI HENSKE MARTHA HICKEY Fox Chase Cancer Center Department of Gynaecology, School of Women’s and Philadelphia, PA Infants’ Health USA WIRF and University of Western Australia [email protected] Crawley, WA Australia [email protected] DONALD E. HENSON The George Washington University Cancer Institute Washington, DC JAMES HICKS USA Cold Spring Harbor Laboratory [email protected] Cold Spring Harbor NY USA MEENHARD HERLYN The Wistar Institute [email protected] Philadelphia, PA USA KEVIN O. HICKS [email protected] Auckland Cancer Society Research Centre The University of Auckland Auckland BLANCA HERNANDEZ-LEDESMA Dept of Nutritional Sciences and Toxicology New Zealand University of California [email protected] Berkeley, CA USA IAN D. HICKSON [email protected] ICRF, Institute of Molecular Medicine University of Oxford John Radcliffe Hospital, Oxford WOLFGANG HERR Department of Medicine III, Hematology and Oncology UK Johannes Gutenberg-University of Mainz [email protected] Mainz Germany COLIN K. HILL [email protected] Department of Radiation Oncology USC Keck School of Medicine Los Angeles, CA HELEN E. HESLOP Center for Cell and Gene Therapy, Baylor College of USA Medicine Texas Children’s Hospital, and The Methodist Hospital BOAZ HIRSHBERG Houston, TX Cardiovascular and Metabolic Diseases, Pfizer Inc USA Groton, CT [email protected] USA [email protected]
JOCHEN HESS Deutsches Krebsforschungszentrum ARI HIRVONEN Division of Signal Transduction and Growth Control Finnish Institute of Occupational Health Heidelberg Helsinki Germany Finland [email protected] [email protected]
MARRY M. VA N D E N HEUVEL-EIBRINK YASUYUKI HITOSHI Department of Pediatric Oncology/Hematology Departments of Pediatrics and of Genetics, Norris Cotton Erasmus MC-Sophia Children’s Hospital Cancer Center Rotterdam Dartmouth Medical School The Netherlands Hanover, NH [email protected] USA [email protected]
DOMINIQUE HEYMANN Physiopathologie de la Résorption Osseuse et Thérapie des RICARDO HITT Tumeurs Osseuses Primitives Medical Oncology Service University of Nantes University Hospital 12 de Octubre Nantes Madrid France Spain [email protected] [email protected] xl List of Contributors
EISO HIYAMA PETRA DEN HOLLANDER Natural Science Center for Basic Research and Development Molecular and Cellular Oncology Department of Pediatric Surgery, Hiroshima University The University of Texas MD Anderson Cancer Center Hospital Houston, TX Hiroshima University USA Hiroshima [email protected] Japan [email protected] CAROLINE L. HOLLOWAY BC Cancer Agency Centre for the Southern Interior FALK HLUBEK Kelowna, BC Department of Pathology Canada Ludwig-Maximilians-University of Munich Munich [email protected] Germany [email protected] ARNE HOLMGREN Department of Medical Biochemistry and Biophysics Karolinska Institutet STEVEN N. HOCHWALD Stockholm Departments of Surgery Sweden Departments of Molecular Genetics and Microbiology [email protected] University of Florida College of Medicine Gainesville, FL JUN HYUK HONG USA The Cancer Institute of NJ, Robert Wood Johnson [email protected] Medical School Division of Urologic Oncology New Brunswick, NJ MICHAEL HODSDON Department of Laboratory Medicine USA Yale University School of Medicine New Haven, CT CHRISTINE HORAK USA Women’s Cancers Section, Laboratory of Molecular [email protected] Pharmacology, Center for Cancer Research National Cancer Institute Bethesda, MD KASPER HOEBE USA Department of Immunology [email protected] The Scripps Research Institute San Diego, CA ADÍLIA HORMIGO USA Department of Neurology [email protected] Memorial Sloan-Kettering Cancer Center New York, NY LORNE J. HOFSETH USA Department of Pharmaceutical and Biomedical Sciences, [email protected] South Carolina College of Pharmacy University of South Carolina J. HORNIG Columbia, SC Head and Neck Tumor Program USA Hollings Cancer Center [email protected] Medical University of South Carolina Charleston, SC USA PANCRAS C. W. HOGENDOORN Department of Pathology MICHAEL R. HORSMAN Leiden University Medical Center Department of Experimental Clinical Oncology Leiden Aarhus University Hospital The Netherlands Aarhus [email protected] Denmark [email protected] STEFAN HOLDENRIEDER Institute of Clinical Chemistry ANDREA KRISTINA HORST University Hospital of Munich Institute of Clinical Chemistry Ludwig-Maximilians-University University Medical Center Hamburg Eppendorf Munich Hamburg Germany Germany [email protected] [email protected] List of Contributors xli
DAVID W. HOSKIN MAUREEN B. HUHMANN Departments of Pathology, and Microbiology and Department of Primary Care, School of Health Related Immunology Professions, University of Medicine and Dentistry of Dalhousie University New Jersey Halifax, NS The Cancer Institute of New Jersey Canada New Brunswick, NJ [email protected] USA [email protected]
ANDREAS F. HOTTINGER WEN-CHUN HUNG Department of Neurology Institute of Biomedical Sciences Memorial Sloan-Kettering Cancer Center National Sun Yat-Sen University New York, NY Kaohsiung, Taiwan USA Republic of China [email protected] [email protected]
KENT HUNTER PETER J. HOUGHTON Department of Molecular Pharmacology Laboratory of Population Genetics, CCR/NCI/NIH St. Jude Children’s Research Hospital Bethesda, MD Memphis, TN USA USA [email protected] [email protected] TONY HUNTER Salk Institute ANTHONY HOWELL Molecular and Cell Biology Laboratory CRUK Department of Medical Oncology La Jolla, CA University of Manchester, Christie Hospital NHS Trust USA Manchester [email protected] UK [email protected] TEH-IA HUO Institute of Pharmacology, School of Medicine National Yang-Ming University SHIE-LIANG HSIEH Taipei, TAIWAN and Department of Microbiology and Immunology Department of Medicine National Yang-Ming University Taipei Veterans General Hospital Immunology Research Center, Taipei Veterans General Taipei, TAIWAN Hospital People’s Rebublic of China Genomics Research Center [email protected] Academia Sinica, Taipei Taiwan JACQUES HUOT [email protected] Le Centre de recherche en cancérologie de l’Université Laval Québec, QC Canada CHENG-LONG HUANG [email protected] Department of Second Surgery Kagawa University DOUGLAS R. HURST Kagawa Department of Pathology and Comprehensive Cancer Center Japan University of Alabama at Birmingham [email protected] Birmingham, AL USA KAY HUEBNER [email protected] Department of Molecular Virology Immunology and Medical Genetics, KAREN L. HUYCK Ohio State University Department of Pathology ’ Comprehensive Cancer Center Brigham and Women s Hospital Columbus, OH Boston, MA USA USA [email protected] [email protected]
SAM T. HWANG PERE HUGUET Dermatology Branch Department of Pathology National Cancer Institute, National Institutes of Health Vall d’Hebron University Hospital Bethesda, MD Barcelona, Spain USA [email protected] [email protected] xlii List of Contributors
BRANDY D. HYNDMAN TOSHIHISA ISHIKAWA Department of Pathology and Molecular Medicine Department of Biomolecular Engineering Queen’s University Cancer Research Institute Graduate School of Bioscience and Biotechnology ’ Queen s University Tokyo Institute of Technology Kingston, ON Meguro-ku Canada Tokyo [email protected] [email protected]
TAKAFUMI ICHIDA Department of Hepatology and Gastroenterology MARK A. ISRAEL Juntendo University School of Medicine, Shizuoka Hospital Departments of Pediatrics and of Genetics, Norris Cotton Shizuoka Cancer Center Japan Dartmouth Medical School [email protected] Hanover, NH USA YOSHITO IHARA [email protected] Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences ANTOINE ITALIANO Nagasaki Laboratory of Solid Tumors Genetics Japan Nice University Hospital and CNRS UMR 6543, Faculty [email protected] of Medicine Nice HITOSHI IKEDA France Department of Pediatric Surgery [email protected] Dokkyo Medical University Koshigaya Hospital Koshigaya, Saitama Japan NORIMASA ITO [email protected] University of Pittsburgh, Departments of Surgery and Bioengineering KAZUHIKO INO Pittsburgh, PA Department of Obstetrics and Gynecology USA Nagoya University Graduate School of Medicine [email protected] Nagoya Japan [email protected] MICHAEL ITTMANN Department of Pathology JUAN IOVANNA Baylor College of Medicine INSERM, Stress Cellulaire, Parc Scientifique et Houston, TX Technologique de Luminy USA Marseille Cedex [email protected] France [email protected] RICHARD IVELL IRMGARD IRMINGER-FINGER Head of School of Molecular and Biomedical Sciences Molecular Gynecology and Obstetrics Laboratory, The University of Adelaide Department of Gynecology and Obstetrics SA Geneva University Hospitals Australia Geneva, Switzerland [email protected] [email protected]
MEREDITH S. IRWIN NOBU IWAKUMA Cell Biology Program and Division of Hematology-Oncology Department of Surgery, Division of Surgical Oncology Hospital for Sick Children University of Florida University of Toronto Gainesville, FL Toronto, ON USA Canada [email protected] [email protected]
PLO ISABELLE SHAI IZRAELI INSERM U790, Hématopoièse et cellules souches Pediatric Hemato-Oncology Institut Gustave Roussy–PR1 Sheba Medical Center and Tel Aviv University Villejuif Ramat Gan France Israel [email protected] [email protected] List of Contributors xliii
PAOLA IZZO GORDON C. JAYSON Dipartimento di Biochimica e Biotechnologie Medicine a Cancer Research UK Department of Medical Oncology Chirurgia, Facoltà di Medicina Christie Hospital Università di Napoli Federico II Manchester Napoli UK Italy [email protected] [email protected]
KUAN-TEH JEANG MARK JACKMAN National Institute of Allergy and Infectious Disease, NIH Wellcome/CRC Institute Bethesda, MD Cambridge USA UK [email protected] [email protected]
JIIANG-HUEI JENG ALAN JACKSON Laboratory of Pharmacology and Toxicology, School of Imaging Science Dentistry University of Manchester National Taiwan University Hospital and National Taiwan Manchester University Medical College UK Taipei [email protected] Taiwan [email protected] DEBORAH JACKSON-BERNITSAS Department of Systems Biology, The University of ELWOOD V. J ENSEN Texas M.D. National Institute of Health Anderson Cancer Center Bethesda, MD Houston, TX USA USA [email protected] [email protected]
LIN JI ULRICH JAEHDE Department of Thoracic & Cardiovascular Surgery Institute of Pharmacy The University of Texas M.D. Anderson Cancer Center University of Bonn Houston, TX Bonn USA Germany [email protected] [email protected]
YUFEI JIANG DAVID JAMIESON School of Clinical and Laboratory Sciences Cancer Vaccine Branch, National Cancer Institute, National Newcastle University Institutes of Health Newcastle upon Tyne Bethesda, MD UK USA [email protected] [email protected]
PIDDER JANSEN-DÜRR CHARLOTTE JIN Institute for Biomedical Ageing Research Departments of Clinical Genetics Austrian Academy of Sciences University Hospital Innsbruck Lund, Sweden Austria [email protected] [email protected] ANDREW K. JOE SIEGFRIED JANZ Department of Medicine Department of Pathology Herbert Irving Comprehensive Cancer Center University of Iowa, Carver College of Medicine New York, NY Iowa City, IA USA USA [email protected] [email protected] ALAN L. JOHNSON DANIEL G. JAY Walther Cancer Research Center Tufts University School of Medicine University of Notre Dame Boston, Ma Notre Dame, IN USA USA [email protected] [email protected] xliv List of Contributors
SARA M. JOHNSON TADAO KAKIZOE Department of Surgery National Cancer Center University of Texas Medical Branch Tokyo Galveston, TX Japan USA [email protected] [email protected] TUULA KALLUNKI FLORIS AART DE JONG Apoptosis Department Department of Medical Oncology Institute of Biological Cancer Research Erasmus University Medical Center Rotterdam Danish Cancer Society Rotterdam Copenhagen The Netherlands Denmark [email protected] [email protected]
WON-A JOO TAKEHIKO KAMIJO The Wistar Institute Division of Biochemistry Philadelphia, PA Chiba Cancer Center Research Institute USA Chuoh-ku, Chiba [email protected] Japan [email protected] V. C RAIG JORDAN Fox Chase Cancer Center YASUFUMI KANEDA Philadelphia, PA Department of Gene Therapy Science USA Osaka University [email protected] Graduate School of Medicine Suita, Osaka SERENE JOSIAH Japan Shire Pharmaceuticals [email protected] Cambridge, MA USA KAZUHIRO KANEKO [email protected] Second Department of Internal Medicine Showa University School of Medicine RICHARD JOVE Tokyo City of Hope National Medical Center and Beckman Japan Research Institute [email protected] Duarte, CA USA [email protected] INKYUNG KANG Department of Surgery University of California JAROSLAW JOZWIAK Department of Histology and Embryology San Francisco, CA Medical University of Warsaw USA Warsaw, Poland [email protected] [email protected] DAVID E. KAPLAN JESPER JURLANDER Division of Gastroenterology Department of Hematology University of Pennsylvania The Finsen Centre Philadelphia, PA Rigshospitalet, Copenhagen USA Denmark [email protected] [email protected] MICHALIS V. K ARAMOUZIS CHAIM KAHANA Department of Biological Chemistry Department of Molecular Genetics Medical School Weizmann Institute of Science University of Athens Rehovot Goudi, Athens Israel Greece [email protected] [email protected]
BERND KAINA ADAM R. KARPF Department of Toxicology Department of Pharmacology and Therapeutics University of Mainz Roswell Park Cancer Institute Mainz Buffalo, NY Germany USA [email protected] [email protected] List of Contributors xlv
NILESH D. KASHIKAR STANLEY B. KAYE Departments of Surgery and Cancer Biology Section of Medicine Vanderbilt-Ingram Cancer Center, Vanderbilt University Institute of Cancer Research, The Royal Marsden Hospital School of Medicine London Nashville, TN UK USA [email protected] [email protected] RICHARD KEFFORD JUHAYNA KASSEM Westmead Institute for Cancer Research and Sydney Division of Pulmonary and Critical Care Medicine Melanoma Unit, University of Sydney Weill Medical College of Cornell University Westmead, NSW New York, NY Australia USA [email protected] [email protected]
MATILDA KATAN EVA N T. KELLER CRC Centre for Cell and Molecular Biology Departments of Urology and Pathology Institute of Cancer Research University of Michigan London Ann Arbor, MI UK USA [email protected] [email protected]
SASSER A. KATE STEPHEN KENNEDY Department of Pediatrics Nuffield Department of Obstetrics and Gynaecology Columbus Children’s Research Institute, The Ohio State Oxford University University John Radcliffe Hospital, Oxford Columbus, OH UK USA [email protected] [email protected]
DANIEL KEPPLER WILLIAM K. KAUFMANN Department of Cell Biology & Anatomy and Feist-Weiller Department of Pathology and Laboratory Medicine Cancer Center University of North Carolina at Chapel Hill LSUHSC-School of Medicine Chapel Hill, NC Shreveport, LA USA USA [email protected] [email protected]
MANJINDER KAUR Department of Pharmaceutical Sciences WOLFGANG KERN School of Pharmacy MLL Munich Leukemia Laboratory University of Colorado Health Sciences Center Munich Denver, CO Germany USA [email protected] [email protected] JORMA KESKI-OJA INGO KAUSCH Departments of Pathology and of Virology Department of Urology Haartman Institute, University of Helsinki University of Luebeck, Medical School Helsinki, Finland Luebeck [email protected] Germany [email protected] AD GEURTS VAN KESSEL Department of Human Genetics KOJI KAWAKAMI Graduate School of Medicine and Public Health Radboud University Nijmegen Medical Centre Kyoto University Nijmegen Kyoto The Netherlands Japan [email protected] [email protected] KHANDAN KEYOMARSI FREDERIC J. KAYE Department of Experimental Radiation Oncology National Cancer Institute Department of Surgical Oncology NIH and National Naval Medical Center Unit 66, University of Texas, MD Anderson Cancer Center Bethesda, MD Houston, TX USA USA [email protected] [email protected] xlvi List of Contributors
CHAND KHANNA SEONG JIN KIM National Cancer Institute, Center for Cancer Research Laboratory of Cell Regulation and Carcinogenesis, National Comparative Oncology Program Cancer Institute Bethesda, MD Bethesda, MD USA USA [email protected] [email protected]
SAMIR KHLEIF SU YOUNG KIM Cancer Vaccine Branch, National Cancer Institute, National Pediatric Oncology Branch, Center for Cancer Research Institutes of Health National Cancer Institute Bethesda, MD Bethesda, MD USA USA [email protected] [email protected],gov
ADI KIMCHI ROYA KHOSRAVI-FAR Department of Molecular Genetics Department of Pathology Weizmann Institute of Science Harvard Medical School, Beth Israel Deaconess Medical Rehovot Center Israel Boston, MA [email protected] USA [email protected] A. DOUGLAS KINGHORN College of Pharmacy, The Ohio State University TOBIAS KIESSLICH Columbus, OH Department of Molecular Biology USA University of Salzburg [email protected] Hellbrunnerstrasse 34, 5020 Salzburg Austria DAVID KIRN [email protected] Jennerex Biotherapeutics Inc. San Francisco, CA FUMITAKA KIKKAWA USA Department of Obstetrics and Gynecology [email protected] Nagoya University Graduate School of Medicine Nagoya YOULIA M. KIROVA Japan Department of Radiation Oncology [email protected] Institut Curie Paris NERBIL KILIC France Department of Hematology and Oncology [email protected] University Hospital Hamburg-Eppendorf Germany SHINICHI KITADA [email protected] Burnham Institute for Medical Research La Jolla, CA USA ISAAC YI KIM The Cancer Institute of NJ, Robert Wood Johnson Medical [email protected] School KAREL KITHIER Division of Urologic Oncology Department of Pathology New Brunswick, NJ Wayne State University School of Medicine USA Detroit, MI [email protected] USA [email protected] JUNG-WHAN KIM Division of Hematology, Department of Medicine CELINA G. KLEER Johns Hopkins University School of Medicine Department of Pathology and Comprehensive Cancer Center Baltimore, MD University of Michigan Medical School MI USA USA [email protected] [email protected]
MOONIL KIM GEORGE KLEIN BioNanotechnology Research Center Microbiology, Tumor and Cell Biology Korea Research Institute of Bioscience and Biotechnology Karolinska Institute Yuseong, Daejeon Stockholm Republic of Korea Sweden [email protected] [email protected] List of Contributors xlvii
MICHAEL J. KLEIN LIN KONG Center for Metabolic Bone Disease Department of Radiation Oncology The University of Alabama at Birmingham Cancer Hospital of Fudan University Birmingham, AL Shanghai USA China [email protected] [email protected]
ELENA KLENOVA Department of Biological Sciences ROLAND E. KONTERMANN University of Essex Institute of Cell Biology and Immunology Colchester University of Stuttgart Essex, Germany UK [email protected] [email protected] JANKO KOS THOMAS KLONISCH Department of Pharmaceutical Biology Department of Human Anatomy and Cell Science University of Ljubljana University of Manitoba Ljubljana Winnipeg, MB Slovenia Canada [email protected] [email protected]
ELIZABETH KNOBLER MARTA KOSTROUCHOVA Department of Dermatology Laboratory of Molecular Biology and Genetics Columbia College of Physicians and Surgeons Institute of Inherited Metabolic Disorders, 1st Faculty of New York, NY Medicine, Charles University USA Prague [email protected] Czech Republica [email protected] ROBERT KNOBLER Department of Dermatology HEINRICH KOVAR Medical University of Vienna Children’s Cancer Research Institute Vienna St. Anna Kinderkrebsforschung, Vienna Austria Austria [email protected] [email protected]
BEATRICE KNUDSEN Divisions of Public Health Sciences, Human Biology and CRAIG KOVITZ Clinical Sciences Department of Medical Oncology Fred Hutchinson Cancer Research Center University of Texas M. D. Anderson Cancer Center Seattle, WA Houston, TX USA USA [email protected] [email protected]
STEFAN KOCHANEK Division of Gene Therapy BARNETT S. KRAMER University of Ulm Office of Disease Prevention Cologne National Institutes of Health Germany Bethesda, MD [email protected] USA [email protected] CHRISTIAN KOLLMANNSBERGER Division of Medical Oncology, British Columbia Cancer BARBARA KRAMMER Agency, Vancouver Cancer Centre Department of Molecular Biology University of British Columbia University of Salzburg Vancouver, BC Salzburg Canada Austria [email protected] [email protected]
YUTAKA KONDO Division of Molecular Oncology HENK J. VAN KRANEN Aichi Cancer Center Research Institute National Institute of Public Health and Environment Nagoya Bilthoven Japan The Netherlands [email protected] [email protected] xlviii List of Contributors
THOMAS KRAUSZ DEEPAK KUMAR Department of Pathology Department of Biological and Environmental Sciences University of Chicago University of the District of Columbia Chicago, IL Washington, DC USA USA [email protected] [email protected]
JÜRGEN KRAUTER HIROKI KUNIYASU Department of Haematology Department of Molecular Pathology Haemostasis and Oncology Nara Medical University School of Medicine Hannover Medical School Kashihara, Nara Hannover Japan Germany [email protected] [email protected] SIAVASH K. KURDISTANI Department of Biological Chemistry BERNHARD KREMENS Department of Pediatric Hematology David Geffen School of Medicine at UCLA Oncology and Respiratory Medicine, University Hospitals of Los Angeles, CA Essen USA Essen [email protected] Germany [email protected] RALF KÜPPERS Institute for Cell Biology (Tumor Research) University of Duisburg-Essen, Medical School ARUNA KRISHNAN Essen Division of Endocrinology Germany Department of Medicine, Stanford University School of [email protected] Medicine Stanford, CA USA ELENA KURENOVA [email protected] Departments of Surgery University of Florida College of Medicine Gainesville, FL BIN B. R. KROON USA Department of Surgery [email protected] The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam KEISUKE KUROSE The Netherlands Departments of Obstetrics and Gynecology [email protected] Nippon Medical School Kawasaki and Tokyo Japan YASUSEI KUDO Department of Oral and Maxillofacial Pathobiology PAULA M. KUZONTKOSKI Division of Frontier Medical Science Departments of Pediatrics and of Genetics, Norris Cotton Graduate School of Biomedical Sciences Cancer Center Hiroshima University Dartmouth Medical School Hiroshima Hanover, NH Japan USA [email protected] [email protected]
RAKESH KUMAR ROBERT M. KYPTA Molecular and Cellular Oncology Cell Biology and Stem Cells Unit The University of Texas MD Anderson Cancer Center CIC bioGUNE, Derio, Bilbao, Spain; Imperial College Houston, TX London USA London [email protected] UK [email protected] PARVESH KUMAR Department of Radiation Oncology JUAN CARLOS LACAL USC Keck School of Medicine Instituto de Investigaciones Biomedicas Los Angeles, CA CSIC, Madrid USA Spain [email protected] [email protected] List of Contributors xlix
JAMES C. LACEFIELD JOSEPH R. LANDOLPH Departments of Electrical and Computer Engineering and Departments of Molecular Microbiology and Immunology, Medical Biophysics and Pathology; USC/Norris Comprehensive Cancer Center, University of Western Ontario Keck School of Medicine; Department of Molecular London, ONT Pharmacology and Pharmaceutical Sciences, School of Canada Pharmacy, Health Sciences Campus [email protected] University of Southern California Los Angeles, CA USA STEPHAN LADISCH [email protected] Children’s Research Institute, Children’s National Medical Center, The George Washington University School of ROBERT LANGER Medicine Department of Chemical Engineering and Center for Cancer Washington, DC Research USA Massachusetts Institute of Technology [email protected] Cambridge, MA USA [email protected] HERMANN LAGE Charité Campus Mitte PAOLA LARGHI Institute of Pathology Department of Immunology Berlin Fondazione Humanitas per la Ricerca Germany Rozzano, Milan [email protected] Italy [email protected]
CHARLES P. K. L AI JAMES M. LARNER Department of Cellular and Physiological Sciences Department of Therapeutic Radiology and Oncology The University of British Columbia University of Virginia School of Medicine Vancouver, BC Charlottesville, VA Canada USA [email protected] [email protected]
GÖRAN LARSON DALE W. LAIRD Department of Anatomy and Cell Biology Department of Clinical Chemistry and Transfusion Medicine University of Western Ontario Institute of Biomedicine London, ON Sahlgrenska Academy at Göteborg University Canada Göteborg [email protected] Sweden [email protected]
JANICE B. B. LAM SUSANNA C. LARSSON Department of Medicine and Genome Research Center Division of Nutritional Epidemiology, Institute of University of Hong Kong Environmental Medicine Hong Kong, China Karolinska Institutet [email protected] Stockholm Sweden [email protected] WAN L. LAM Department of Cancer Genetics and Developmental Biology PHILIPPE LASSALLE British Columbia Cancer Research Centre INSERM U774 Vancouver, BC Institut Pasteur de Lille Canada Lille [email protected] France [email protected]
HUI Y. L AN FARIDA LATIF Department of Medicine Department of Medical and Molecular Genetics, Institute of The University of Hong Kong Li Ka Shing Faculty of Biomedical Research Medicine University of Birmingham Hong Kong Birmingham China UK [email protected] [email protected] l List of Contributors
VIRPI LAUNONEN WILLIAM P. J. L EENDERS Department of Medical Genetics, Biomedicum Helsinki Department of Pathology University of Helsinki Radboud University Nijmegen Medical Center Helsinki Nijmegen Finland The Netherlands [email protected] [email protected]
VINCENZO DE LAURENZI ANDREAS LEIBBRANDT Department of Experimental Medicine and Biochemical Institute of Molecular Biotechnology of the Austrian Sciences Academy of Sciences University of Tor Vergata Vienna Rome Austria Italy [email protected] [email protected]
GWENDAL LAZENNEC MANUEL C. LEMOS INSERM Academic Endocrine Unit, Nuffield Department of Clinical Montpellier Medicine, University of Oxford, Oxford Centre for Diabetes France Endocrinology and Metabolism (OCDEM), Churchill [email protected] Hospital Headington, Oxford GAIL S. LEBOVIC UK Director of Women’s Services [email protected] The Cooper Clinic Dallas, TX ERIC J. LENTSCH USA Head and Neck Tumor Program [email protected] Hollings Cancer Center Medical University of South Carolina DAV ID P. L EBRUN Charleston, SC Department of Pathology and Molecular Medicine USA Queen’s University Cancer Research Institute, Queen’s [email protected] University Kingston, ON Canada YUN-CHUNG LEUNG [email protected] Lo Ka Chung Centre for Natural Anti-cancer Drug Development and Department of Applied Biology and Chemical Technology CHEONG J. LEE The Hong Kong Polytechnic University Department of Surgery Hung Hom, Kowloon, Hong Kong University of Michigan Medical Center China Ann Arbor, MI [email protected] USA
JONG-HEUN LEE FRANCIS LÉVI Women’s Cancers Section, Laboratory of Molecular INSERM, Rythmes Biologiques et Cancers Pharmacology, Center for Cancer Research Hospital Paul Brousse, Villejuif Cedex National Cancer Institute France Bethesda, MD Université Paris Sud XI USA Orsay [email protected] France [email protected] SEAN BONG LEE Genetics of Development and Disease Branch, National Institute of Diabetes & Digestive & Kidney Diseases JAY A. LEVY National Institutes of Health University of California, School of Medicine Bethesda, MD San Francisco, CA USA USA [email protected] [email protected]
STEPHEN LEE KAIYI LI Department of Cellular and Molecular Medicine Department of Surgery Faculty of Medicine, University of Ottawa Baylor College of Medicine Ottawa, ONT Houston, TX Canada USA [email protected] [email protected] List of Contributors li
DAIQING LIAO JOSEPH LIPSICK Department of Anatomy and Cell Biology, Shands Cancer Stanford University Center Stanford, CA University of Florida College of Medicine USA Gainesville, FL [email protected] USA [email protected] FEI-FEI LIU Department of Medical Biophysics, Princess Margaret EMMANUELLE LIAUDET-COOPMAN Hospital/Ontario Cancer Institute INSERM U826 University Health Network CRLC Val d’Aurelle University of Toronto Parc Euromédecine, Montpellier Cedex 5 Toronto, ON France Canada [email protected] [email protected]
ROSSELLA LIBÈ XIANGGUO LIU INSERM U567, Institut Cochin Winship Cancer Institute Endocrinology, Metabolism and Cancer Department Emory University Paris Atlanta, GA France USA [email protected] KE LIN Department of Haematology TING LING LO Royal Liverpool University Hospital Signal Transduction Laboratory Liverpool Institute of Molecular and Cell Biology UK Singapore [email protected] [email protected]
SHENG-CAI LIN VICTOR LOBANENKOV Department of Biomedical Sciences, School of Life Sciences Section of Molecular Pathology, NIAID Xiamen University, Xiamen National Institutes of Health Fujian Bethesda, MD China USA [email protected] [email protected]
SHIAW-YIH LIN Department of Systems Biology, The University of Texas HOLGER N. LODE M.D. Anderson Cancer Center Charité University Medicine Berlin Houston, TX Pediatrics, Berlin USA Germany [email protected] [email protected]
WAN-WAN LIN LAWRENCE A. LOEB Department of Pharmacology University of Washington College of Medicine Seattle, WA National Taiwan University USA Taipei [email protected] Taiwan [email protected] ROBERT LOEWE Department of Dermatology, Division of General JANET C. LINDSEY Dermatology Northern Institute for Cancer Research Medical University of Vienna Newcastle University Vienna Newcastle upon Tyne Austria UK [email protected] [email protected] STEFFEN LOFT CHRISTOPHER A. LIPINSKI Institute of Public Health Scientific Advisor, Melior Discovery Department of Occupational and Environmental Health Waterford University of Copenhagen, København K USA Denmark [email protected] [email protected] lii List of Contributors
DIETMAR LOHMANN JOCHEN LORCH Institut für Humangenetik Dana Farlur Cancer Institute Head and Neck Oncology Universitätsklinikum Essen Program Essen Boston, MA Germany USA [email protected] [email protected]
EDITH M. LORD MATTHIAS LÖHR Department of Microbiology & Immunology Molecular Gastroenterology Unit, German Cancer Research University of Rochester School of Medicine and Dentistry Center (dkfz E180) Heidelberg and Department of Rochester, NY Medicine II, Mannheim Medical Faculty USA University of Heidelberg [email protected] Heidelberg Germany GIUSEPPE DI LORENZO [email protected] Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia molecolare e clinica Università degli Studi “Federico II” VINATA B. LOKESHWAR Department of Urology, Cell Biology and Anatomy Napoli Sylvester Comprehensive Cancer Center, University of Italy Miami Miller School of Medicine [email protected] Miami, FL USA REUBEN LOTAN [email protected] Department of Thoracic Head and Neck Medical Oncology The University of Texas, MD Anderson Cancer Center Houston, TX ALEXANDRE LOKTIONOV USA Colonix Medical Limited [email protected] Babraham Research Campus Cambridge RAGNHILD A. LOTHE UK Department of Cancer Prevention [email protected] Rikshospitalet-Radiumhospitalet Medical Centre Oslo Norway ELIAS LOLIS [email protected] Department of Pharmacology Yale University School of Medicine MICHAEL T. LOTZE New Haven, CT University of Pittsburgh, Departments of Surgery and USA Bioengineering [email protected] Pittsburgh, PA USA [email protected] PIER-LUIGI LOLLINI Section of Cancer Research CHRYSTAL U. LOUIS Department of Experimental Pathology Center for Cell and Gene Therapy, Baylor College of University of Bologna Medicine Bologna Texas Children’s Hospital, and The Methodist Hospital Italy Houston, TX [email protected] USA [email protected] MIGUEL LOPEZ-LAZARO Department of Pharmacology DMITRI LOUKINOV Faculty of Pharmacy, University of Seville, Seville Section of Molecular Pathology Spain NIAID NIH WT-I bldg [email protected] Rockville, MD USA [email protected] CHARLES L. LOPRINZI Division of Oncology DAVID B. LOVEJOY Department of Internal Medicine Department of Pathology Mayo Clinic College of Medicine University of Sydney Rochester, MN NSW USA Australia [email protected] [email protected] List of Contributors liii
JIADE J. LU JIAN-HUA LUO Department of Radiation Oncology Department of Pathology Cancer Hospital of Fudan University University of Pittsburgh Shanghai Pittsburgh, PA China USA [email protected] [email protected]
TZONG-SHI LU GARY H. LYMAN Division of Experimental Medicine Cancer Center Beth Israel Deaconess Medical Center, Harvard Institutes University of Rochester Medical Center of Medicine Rochester, NY Boston, MA USA USA [email protected] [email protected]
HENRY LYNCH YUANAN LU Department of Public Health Science Hereditary Cancer Institute University of Hawaii Creighton University Honolulu, HI Omaha, NE USA USA [email protected] [email protected]
IRINA A. LUBENSKY ELSEBETH LYNGE National Cancer Institute Institute of Public Health National Institutes of Health University of Copenhagen Bethesda, MD Denmark, Copenhagen USA [email protected] [email protected]
SCOTT K. LYONS DARIO DI LUCA Molecular Imaging Group Department of Experimental and Diagnostic Medicine CRUK Cambridge Research Institute, Li Ka Shing Centre University of Ferrara Cambridge Ferrara, Italy UK [email protected] [email protected]
JARED LUCAS Divisions of Public Health Sciences, Human Biology and MICHAEL MACMANUS Clinical Sciences Department of Radiation Oncology Fred Hutchinson Cancer Research Center Peter MacCallum Cancer Institute Seattle, WA East Melbourne, VIC USA Australia [email protected] [email protected]
ANDREAS LUCH BRITTA MÄDGE Federal Institute for Risk Assessment DKFZ Berlin Heidelberg Germany Germany [email protected]
CLAUDIE MADOULET BEN O. DE LUMEN Dept of Nutritional Sciences and Toxicology Laboratory of Biochemistry University of California IFR53, Faculty of Pharmacy Berkeley, CA Reims Cedex USA France [email protected] [email protected]
MARIA LI LUNG FÉLIX FERNÁNDEZ MADRID Department of Biology and Center for Cancer Research Department of Internal Medicine Hong Kong University of Science and Technology Karmanos Cancer Institute and Center for Molecular Clearwater Bay Medicine and Genetics, Wayne State University Kowloon, Hong Kong Detroit, MI (SAR) People's Republic of China USA [email protected] [email protected] liv List of Contributors
ROLANDO F. DEL MAESTRO ALBERTO MANTOVANI Brain Tumour Research Centre, Montreal Neurological Department of Immunology Institute, McGill University Fondazione Humanitas per la Ricerca Montreal, QC Rozzano, Milan Canada Italy [email protected] [email protected]
ASHLEY A. MANZOOR BRINDA MAHADEVAN Department of Radiation Oncology Department of Environmental and Molecular Toxicology Duke University Oregon State University Durham, NC Corvallis, OR USA USA [email protected] [email protected]
LUCIA MARCOCCI CSABA MAHOTKA Department of Biochemical Sciences “A. Rossi Fanelli” Institute of Pathology Sapienza University of Rome Heinrich Heine Universität Rome Düsseldorf Italy Germany [email protected] [email protected] DIETER MARMÉ Tumor Biology Center SOURINDRA N. MAITI Institute of Molecular Oncology Division of Pediatrics, Department of Immunology Freiburg M.D. Anderson Cancer Center Germany Houston, TX [email protected] USA [email protected] DEBORAH J. MARSH Kolling Institute of Medical Research CÉDRIC MALICET University of Sydney INSERM, Stress Cellulaire, Parc Scientifique et NSW Technologique de Luminy Australia Marseille Cedex [email protected] France [email protected] JOHN L. MARSHALL Georgetown University Lombardi Comprehensive Cancer Center ALESSANDRA MANCINO Washington, DC Department of Immunology USA Fondazione Humanitas per la Ricerca [email protected] Rozzano, Milan Italy [email protected] RENÉE M. MARSHALL The Wistar Institute Molecular and Cellular Oncogenesis Program EVELYNE MANET Philadelphia, PA INSERM U758, Ecole Normale Supérieure de Lyon USA Lyon [email protected] France [email protected] ANGELA MÄRTEN National Centre for Tumour Diseases, Department of Surgery SRIDHAR MANI University Hospital Heidelberg Department of Medicine, Oncology and Molecular Genetics Heidelberg Albert Einstein College of Medicine Germany NY [email protected] USA [email protected] EDMUND MASER Institute of Toxicology and Pharmacology for Natural MARCEL MANNENS Scientists Academic Medical Centre, University of Amsterdam University Medical School Amsterdam Kiel The Netherlands Germany [email protected] [email protected] List of Contributors lv
THOMAS E. MASSEY JOSEPH H. MCCARTY Department of Pharmacology and Toxicology University of Texas, M.D. Anderson Cancer Center Queen’s University Houston, TX Kingston, ONT USA Canada [email protected] [email protected] KATHERINE A. MCGLYNN NORIYUKI MASUDA Division of Cancer Epidemiology and Genetics Department of Respiratory Medicine National Cancer Institute Kitasato University School of Medicine National Institutes of Health Sagamihara, Kanagawa Bethesda, MD Japan USA [email protected] [email protected]
ATSUKO MASUMI W. GLENN MCGREGOR National Institute of Infectious Diseases, James Graham Brown Cancer Center Musashimurayama-shi University of Louisville School of Medicine Tokyo Louisville, KY Japan USA [email protected] [email protected]
YASUNOBU MATSUDA IAIN H. MCKILLOP Department of Hepatology and Gastroenterology Department of Biology Juntendo University School of Medicine, Shizuoka Hospital The University of North Carolina at Charlotte Shizuoka Charlotte, NC Japan USA [email protected] SACHIKO MATSUHASHI Department of Internal Medicine ROGER E. MCLENDON Saga Medical School Department of Pathology Saga University Duke University Medical Center Saga Durham, NC Japan USA [email protected] [email protected]
TAKAYA MATSUZUKA DONALD C. MCMILLAN Department of Anatomy and Physiology University Department of Surgery Kansas State University Royal Infirmary Manhattan, KS Glasgow USA UK [email protected] [email protected]
MALGORZATA MATUSIEWICZ ARIANEB MEHRABI Department of Medical Biochemistry Department of General Wroclaw Medical University Visceral and Transplantation Surgery Wroclaw University of Heidelberg Poland Heidelberg [email protected] Germany [email protected] WARREN L. MAY Department of Preventive Medicine ANIL MEHTA University of Mississippi Medical Center Maternal and Child Health Sciences Jackson, MS University of Dundee USA Dundee [email protected] UK [email protected] MATTHEW A. MCBRIAN Department of Biological Chemistry KAPIL MEHTA David Geffen School of Medicine at UCLA The University of Texas MD Anderson Cancer Center Los Angeles, CA Houston, TX USA USA [email protected] [email protected] lvi List of Contributors
REKHA MEHTA STEPHAN MIELKE Toxicology Research Division, Bureau of Chemical Safety Hematology Branch, National Heart, Lung and Blood Food Directorate, HPFB, Health Canada Institute (NHLBI) Ottawa, ONT National Institutes of Health (NIH) Canada Bethesda, MD [email protected] USA [email protected]
ELVIRA DE MEJIA Department of Food Science and Human Nutrition TAKEO MINAGUCHI University of Illinois Department of Obstetrics and Gynecology Urbana-Champaign, IL Toranomon Hospital USA Tokyo [email protected] Japan [email protected]
BAR-ELI MENASHE Department of Cancer Biology NAGAHIRO MINATO The University of Texas, M.D. Anderson Cancer Center Department of Immunology and Cell Biology Houston, TX Graduate School of Medicine, Kyoto University USA Kyoto [email protected] Japan [email protected]
HEATHER MERNITZ Jean Mayer USDA Human Nutrition Research Center on RODNEY F. MINCHIN Aging at Tufts University School of Biomedical Sciences Boston, MA University of Queensland USA St Lucia, QLD [email protected] Australia [email protected]
JENNIFER A. MERTZ JOHN D. MINNA Section of Molecular Genetics and Microbiology and Institute Hamon Center for Therapeutic Oncology Research and for Cellular and Molecular Biology Departments of Pathology, Internal Medicine and The University of Texas at Austin Pharmacology Austin, TX University of Texas Southwestern Medical Center USA Dallas, TX [email protected] USA [email protected]
KARL-HEINZ MERZ Department of Chemistry, Division of Food Chemistry and CLAUDIA MITCHELL Toxicology Institut Cochin University of Kaiserslautern Université Paris Descartes, CNRS Kaiserslautern Paris Germany France [email protected] [email protected]
JUN MI KAZUO MIYASHITA Department of Therapeutic Radiology and Oncology Department of Bioresources Chemistry, Faculty of Fisheries University of Virginia School of Medicine Sciences Charlottesville, VA Hokkaido University USA Hakodate [email protected] Japan [email protected]
DENNIS F. MICHIEL Biopharmaceutical Development Program EIJI MIYOSHI SAIC-Frederick, Inc. Department of Biochemistry National Cancer Institute-Frederick Osaka University Graduate School of Medicine Frederick, MD Suita USA Japan [email protected] [email protected] List of Contributors lvii
JUN MIYOSHI WOLTER J. MOOI Department of Molecular Biology Department of Pathology Osaka Medical Center for Cancer and Cardiovascular VU Medical Center Diseases Amsterdam Osaka The Netherlands Japan [email protected] [email protected] AMY C. MOORE Vanderbilt University Medical Center TOSHIHIKO MIZUTA Department of Internal Medicine Nashville, TN Saga Medical School USA Saga [email protected] Japan [email protected] MALCOLM A. S. MOORE Department of Cell Biology Memorial-Sloan-Kettering Cancer Center K. THOMAS MOESTA New York, NY Klinik für Chirurgie und Chirurgische Onkologie USA Robert Rössle-Klinik, Charité [email protected] Berlin-Buch, Berlin Germany CESAR A. MORAN [email protected] Department of Pathology M D Anderson Cancer Center SONIA MOHINTA Houston, TX Department of Medical Microbiology, Immunology and Cell USA Biology [email protected] Southern Illinois University, School of Medicine Springfield, IL JAQUELINE MORENO USA Division of Endocrinology [email protected] Department of Medicine, Stanford University School of Medicine Stanford, CA JAN MOLLENHAUER USA Division of Molecular Genome Analysis, DKFZ [email protected] Heidelberg Germany [email protected] SERGIO MORENO Instituto de Biología Molecular y Celular del Cáncer CSIC/Universidad de Salamanca MICHAEL B. MØLLER Campus Miguel de Unamuno, Salamanca Department of Pathology, Division of Hematopathology Spain Odense University Hospital [email protected] Odense Denmark FABIOLA MORETTI [email protected] Institute of Neurobiology and Molecular Medicine, National Council of Research/Molecular Oncogenesis Laboratory “ ” BRUNO MONDOVÌ Regina Elena Cancer Institute Department of Biochemical Sciences “A. Rossi Fanelli” Rome Sapienza University of Rome Italy Rome [email protected] Italy [email protected] EIICHIRO MORI Department of Biology Nara Medical University School of Medicine ALESSANDRA MONTECUCCO Kashihara, Nara Istituto di Genetica Molecolare CNR Japan via Abbiategrasso, Pavia [email protected] Italy [email protected] AKIRA MORIMOTO Department of Pediatrics RUGGERO MONTESANO Kyoto Prefectural University of Medicine Courmayeur Kyoto Italy Japan [email protected] [email protected] lviii List of Contributors
PAT J. MORIN H. K. MÜLLER-HERMELINK Laboratory of Cellular and Molecular Biology Institute of Pathology National Institute on Aging, NIH University of Würzburg Baltimore, MD Würzburg USA Germany [email protected] [email protected]
CHRISTINE M. MORRIS LOIS M. MULLIGAN Cancer Genetics Research Group Department of Pathology & Molecular Medicine University of Otago at Christchurch Queen’s University Christchurch Kingston, ON New Zealand Canada [email protected] [email protected]
RAMACHANDRAN MURALI GABRIELA MÖSLEIN Department of Pathology and Laboratory Medicine & Chefärztin für Allgemein- und Viszeralchirurgie Abramson Cancer Center Bochum University of Pennsylvania Germany Philadelphia, PA [email protected] USA [email protected] CYNTHIA C. MORTON Department of Pathology KENJI MURO Brigham and Women’s Hospital Department of Neurological Surgery, Northwestern Boston, MA University Feinberg School of Medicine USA Robert H. Lurie Comprehensive Cancer Center [email protected] Chicago, IL USA JUSTIN L. MOTT [email protected] Miles and Shirley Fiterman Center for Digestive Diseases Division of Gastroenterology and Hepatology EDWARD L. MURPHY Mayo Clinic College of Medicine University of California, School of Medicine Rochester, MN San Francisco, CA USA USA [email protected] [email protected]
SPYRO MOUSSES PAUL G. MURRAY Cancer Genetics Branch CRUK Institute for Cancer Studies, Molecular Pharmacology, National Human Genome Research Institute, NIH Medical School Bethesda, MD University of Birmingham USA Birmingham [email protected] UK [email protected]
SEBASTIAN MUELLER MARKUS MÜSCHEN Department of Medicine Leukemia and Lymphoma Program, Norris Comprehensive Salem Medical Center, Heidelberg, Center of Alcohol Cancer Center Research Liver Disease and Nutrition and University of University of Southern California Heidelberg Los Angeles, CA Heidelberg, Germany USA [email protected] [email protected]
SUSETTE C. MUELLER RUTH J. MUSCHEL Lombardi Comprehensive Cancer Center Radiation Oncology and Biology Georgetown University Medical Center University of Oxford Washington, DC Oxford, UK USA [email protected] [email protected] AKIRA NAGANUMA ROLF MÜLLER Laboratory of Molecular and Biochemical Toxicology Institute of Molecular Biology and Tumor Research (IMT) Graduate School of Pharmaceutical Sciences Philipps-University Marburg Tohoku University Marburg Sendai Germany Japan [email protected] [email protected] List of Contributors lix
SHIGEKAZU NAGATA TIM S. NAWROT Osaka University Medical School Division of Lung Toxicology Osaka Department of Occupational and Environmental Medicine Japan (T.S.N.) and the Studies Coordinating Centre (J.A.S.) [email protected] Division of Hypertension and Cardiovascular Rehabilitation Department of Cardiovascular Diseases University of Leuven RITA NAHTA Leuven Department of Breast Medical Oncology Belgium The University of Texas MD Anderson Cancer Center [email protected] Houston, TX USA Breast Cancer Translational Research Laboratory DAVID F. NELLIS The University of Texas MD Anderson Cancer Center Biopharmaceutical Development Program Houston, TX SAIC-Frederick, Inc. USA National Cancer Institute-Frederick [email protected] Frederick, MD USA [email protected] AKIRA NAKAGAWARA Chiba Cancer Center Research Institute PETER NELSON Chiba Divisions of Public Health Sciences, Human Biology and Japan Clinical Sciences [email protected] Fred Hutchinson Cancer Research Center Seattle, WA TETSUYA NAKATSURA USA Section for Frontier Medicine, Investigative Treatment [email protected] Division, Research Center for Innovative Oncology National Cancer Center Hospital East KENNETH P. N EPHEW Kashiwa City, Chiba Prefecture Medical Sciences Japan Indiana University School of Medicine [email protected] Bloomington, IN USA PATRIZIA NANNI [email protected] Section of Cancer Research Department of Experimental Pathology KORNELIA NEVELING University of Bologna Department of Human Genetics Bologna University of Wurzburg Italy Wurzburg [email protected] Germany [email protected] ZVI NAOR Department of Biochemistry, The George S. Wise Faculty of BRAD WNEVILLE Life Sciences Head and Neck Tumor Program Tel Aviv University Hollings Cancer Center Ramat Aviv Medical University of South Carolina Israel Charleston, SC [email protected] USA [email protected]
KEVIN T. NASH Department of Pathology and Comprehensive Cancer Center KLAUS NEUHAUS University of Alabama-Birmingham Department of Operative, Preventive and Paediatric Dentistry Birmingham, AL School of Dental Medicine, University of Bern USA Bern [email protected] Switzerland [email protected]
CHRISTIAN C. NAUS Department of Cellular and Physiological Sciences IRENE O. L. NG The University of British Columbia Department of Pathology Vancouver, BC The University of Hong Kong Canada Hong Kong [email protected] [email protected] lx List of Contributors
DUC NGUYEN LARRY NORTON Associate Research Scientist Breast Cancer Medicine Service Yale University School of Medicine Department of Medicine New Haven, CT Memorial Sloan-Kettering Cancer Center USA New York, NY [email protected] USA [email protected] CAROLE NICCO Faculté de Médecine Paris – Descartes UPRES 18-33, Groupe Hospitalier Cochin – Saint Vincent de FRANCISCO J. NOVO Paul Department of Genetics Paris University of Navarra France Pamplona, Spain [email protected] [email protected]
SANTO V. N ICOSIA RUSLAN NOVOSYADLYY Molecular Oncology Program & Research Institute, H. Lee Division of Endocrinology, Diabetes and Bone Diseases Moffitt Cancer Center Departmant of Medicine University of South Florida College of Medicine Mount Sinai School of Medicine Tampa, FL New York, NY USA USA [email protected] [email protected]
ANNE T. NIES Division of Tumor Biochemistry NOA NOY German Cancer Research Center Department of Pharmacology Heidelberg Case-Western Reserve University School of Medicine Germany Cleveland, OH [email protected] USA [email protected] M. ANGELA NIETO Instituto de Neurociencias de Alicante CSIC-UMH Sant Joan d’Alacant HALA H. NSOULI Spain Department of Epidemiology and Biostatistics [email protected] The George Washington University School of Public Health and Health Services OMGO E. NIEWEG Washington, DC Department of Surgery USA The Netherlands Cancer Institute [email protected] Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands LAUREN M. NUNEZ [email protected] Department of Cell Biology & Anatomy and Feist-Weiller Cancer Center LSUHSC-School of Medicine JONAS NILSSON Department of Clinical Chemistry and Transfusion Medicin Shreveport, LA Institute of Biomedicine USA Sahlgrenska academy at Göteborg University [email protected] Göteborg Sweden ANDRÉ OBERTHÜR [email protected] Department of Pediatric Oncology and Hematology Children’s Hospital EWA NINIO University of Cologne INSERM UMRS Cologne Université Pierre et Marie Curie-Paris Germany Paris [email protected] France [email protected] TAKAHIRO OCHIYA DOUGLAS NOONAN Section for Studies on Metastasis University of Insubria National Cancer Center Research Institute Varese Chuo-ku, Tokyo Italy Japan [email protected] [email protected] List of Contributors lxi
JAMES P. B. O’CONNOR RUTH M. O’REGAN Imaging Science Winship Cancer Institute University of Manchester Emory University Manchester Atlanta, GA UK USA james.o'[email protected] [email protected]
SARAH T. O’DWYER Department of Surgery GERTRAUD OREND University of Manchester Departement Klinisch-Biologische Wissenschaften (DKBW) Christie Hospital NHS Foundation Trust Center for Biomedicine, Institute of Biochemistry and Manchester Genetics UK University of Basel [email protected] Basel Switzerland [email protected] STEFAN OFFERMANNS Institute of Pharmacology, University of Heidelberg Heidelberg MAKOTO OSANAI Germany Department of Pathology [email protected] Sapporo Medical University School of Medicine Sapporo ANAT OHALI Japan Cancer Vaccine Branch, National Cancer Institute, National [email protected] Institutes of Health Bethesda, MD USA EDUARDO OSINAGA [email protected] Departamento de Inmunobiología, Facultad de Medicina Universidad de la República TAKEO OHNISHI Montevideo Department of Biology Uruguay Nara Medical University School of Medicine [email protected] Kashihara, Nara Japan [email protected] FRANCISO RUIZ-CABELLO OSUNA Hospital Universitario Virgen de las Nieves HITOSHI OHNO Granada Department of Internal Medicine, Faculty of Medicine Spain Kyoto University [email protected] Kyoto Japan [email protected] G. OTT Institute of Pathology Robert-Bosch Krankenhaus KEVIN R. OLDENBURG Stuttgart MatriCal, Inc. Germany Spokane, WA [email protected] USA [email protected]
CHRISTIAN OTTENSMEIER MAGALI OLIVIER CRC Wessex Oncology Unit, Southampton General Hospital Group of Molecular Carcinogenesis and Biomarkers and Tenovous Laboratory International Agency for Research on Cancer Southampton University Hospital Trust World Health Organization Southampton Lyon Cedex 08 UK France [email protected] [email protected]
MILITSAKH ON IWATA OZAKI Head and Neck Tumor Program Health Administration Center Hollings Cancer Center Saga Medical School Medical University of South Carolina Saga University Charleston, SC Saga USA Japan [email protected] [email protected] lxii List of Contributors
SHUJI OZAKI BEN HO PARK Department of Medicine and Bioregulatory Sciences The Sidney Kimmel Comprehensive Cancer Center, Johns The University of Tokushima Graduate School of Health Hopkins University Biosciences Baltimore, MD Tokushima USA Japan [email protected] [email protected] GEOFF J. M. PARKER HELEN PACE Imaging Science Department of Molecular Virology University of Manchester Immunology and Medical Genetics, Ohio State University Manchester Comprehensive Cancer Center UK Columbus, OH [email protected] USA [email protected] SARAH J. PARSONS University of Virginia SIMON C. PACEY Charlotteville, VA Cancer Research UK Center for Cancer Therapeutics USA The Institute of Cancer Research [email protected] Sutton, Surrey UK [email protected] ONEEL PATEL Department of Surgery University of Melbourne, Austin Health PIER PAOLO PANDOLFI Melbourne, VIC Memorial Sloan-Kettering Cancer Center Australia Weill Cornell Graduate School of Medical Sciences [email protected] NY USA [email protected] PATRIZIA PATERLINI-BRÉCHOT INSERM Unit 807, Faculté de Médecine Necker Enfants Malades, Paris V, Paris KLAUS PANTEL France Universitäts-Krankenhaus Eppendorf [email protected] Hamburg Germany [email protected] YVONNE PATERSON Professor of Microbiology University of Pennsylvania MELISSA C. PAOLONI National Cancer Institute, Center for Cancer Research Philadelphia, PA Comparative Oncology Program USA Bethesda, MD [email protected] USA [email protected],gov KONAN PECK Institute of Biomedical Sciences EVANGELIA PAPADIMITRIOU Academia Sinica Taipei Department of Pharmacy Taiwan University of Patras Republic of China Patras [email protected] Greece [email protected] FLORENCE PEDEUTOUR Laboratory of Solid Tumors Genetics ATHANASIOS G. PAPAVASSILIOU Nice University Hospital and CNRS UMR 6543 Department of Biological Chemistry, Medical School Faculty of Medicine University of Athens Nice Goudi, Athens France Greece [email protected] [email protected] DAN PEER SABITHA PAPINENI Departments of Anesthesia and Immunology, CBR Institute Department of Veterinary Physiology and Pharmacology for Biomedical Research Texas A&M University Harvard Medical School College Station, TX Boston, MA USA USA [email protected] [email protected] List of Contributors lxiii
MIGUEL A. PEINADO GODEFRIDUS J. PETERS Institue of Predictive and Personalized Medicine of Cancer Department of Medical Oncology (IMPPC) VU University Medical Center Badalona Amsterdam Barcelona, Spain The Netherlands [email protected] [email protected]
ANGEL PELLICER MARLEEN M. R. PETIT Department of Pathology Department of Human Genetics New York University School of Medicine University of Leuven New York, NY Leuven USA Belgium [email protected] [email protected]
JUHA PELTONEN PETER PETZELBAUER Department of Anatomy, Institute of Biomedicine Department of Dermatology, Division of General University of Turku Dermatology Turku Medical University of Vienna Finland Vienna [email protected] Austria [email protected]
SIRKKU PELTONEN Department of Dermatology CLAUDIA PFÖHLER University of Turku Department of Dermatology Turku Saarland University Medical School Finland Homburg/Saar, Germany [email protected] [email protected]
JOSEF M. PENNINGER MICHAEL PFREUNDSCHUH Institute of Molecular Biotechnology of the Austrian Klinik für Innere Medizin I Academy of Sciences Universität des Saarlandes Vienna Homburg Austria Germany [email protected] [email protected]
MAIKEL P. P EPPELENBOSCH PHILIP A. PHILIP University Medical Center Groningen Karmanos Cancer Institute University of Groningen Wayne State University Groningen Detroit, MI The Netherlands USA [email protected] [email protected]
MÓNICA PÉREZ-RÍOS MARCO A. PIEROTTI Department of Preventive Medicine and Public Health Scientific Director University of Santiago de Compostela IRCCS Istituto Nazionale Tumori Foundation C/San Francisco Milan Spain Italy [email protected] [email protected]
FRANCISCO G. PERNAS PAOLA PIETRANGELI National Institute on Deafness and Other Communication Department of Biochemical Sciences-A. Rossi Fanelli Disorders and National Cancer Institute NIH Sapienza University of Rome Bethesda, MD Rome USA Italy [email protected]
SILVERIO PERROTTA Department of Pediatrics TORSTEN PIETSCH Second University of Naples Institut für Neuropathologie Naples Universitätskliniken Bonn, Bonn Italy Germany Kinderchirurgie [email protected] [email protected] lxiv List of Contributors
MICHAEL PISHVAIAN JEFFREY W. POLLARD Georgetown University Department of Developmental and Molecular Biology, Center Lombardi Comprehensive Cancer Center for the Study of Reproductive Biology and Women’s Health Washington, DC Albert Einstein College of Medicine USA Bronx, NY [email protected] USA [email protected] ELLEN S. PIZER Laboratory of Cellular and Molecular Biology SIMONA POLO National Institute on Aging, NIH University of Milan, Medical School Baltimore, MD Milan USA Italy [email protected] CHRISTOPH PLASS German cancer Research cener (DKFZ) BRUCE A. J. PONDER Heidelberg Department of Oncology Germany University of Cambridge [email protected] Cambridge UK LEONIDAS C. PLATANIAS [email protected] Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Department of Medicine MIRCO PONZONI Northwestern University Medical School Differentiation Therapy Unit, Laboratory of Oncology Chicago, IL G. Gaslini Children’s Hospital USA Genoa [email protected] Italy [email protected] JEFFREY L. PLATT Transplantation Biology and the Departments of Surgery BEATRICE L. POOL-ZOBEL Immunology and Pediatrics Nutritional Toxicology Mayo Clinic Friedrich-Schiller-University of Jena Rochester, MN Jena USA Germany [email protected] [email protected]
MARK R. PLAYER Johnson & Johnson Pharmaceutical Research & Development CHRISTOPHER S. POTTEN Exton, PA Epistem Ltd and School of Biological Sciences USA University of Manchester [email protected] Manchester UK [email protected] IRIS M. C. VAN DER PLOEG Department of Surgery The Netherlands Cancer Institute ANNEMARIE POUSTKA Antoni van Leeuwenhoek Hospital Division of Molecular Genome Analysis, DKFZ Amsterdam Heidelberg The Netherlands Germany [email protected] [email protected]
KLAUS PODAR MARISSA V. P OWERS Department of Medical Oncology, Jerome Lipper Multiple Cancer Research UK Centre for Cancer Therapeutics Myeloma Center The Institute of Cancer Research Dana-Farber Cancer Institute Sutton, Surrey Boston, MA UK USA [email protected] [email protected] GARTH POWIS MIRIAM C. POIRIER Department of Experimental Therapeutics National Cancer Institute, NIH M.D. Anderson Cancer Center Bethesda, MD Houston, TX USA USA [email protected] [email protected] List of Contributors lxv
GRAZIELLA PRATESI CHAO-NAN QIAN Fondazione IRCCS Istituto Nazionale dei Tumori Laboratory of Cancer Genetics Milan Van Andel Research Institute Italy Grand Rapids, MI [email protected] USA [email protected]
GEORGE C. PRENDERGAST Department of Pathology, Anatomy and Cell Biology JIAHUA QIAN Jefferson Medical School Cancer Vaccine Branch, National Cancer Institute, National Lankenau Institute for Medical Research Institutes of Health Wynnewood, PA Bethesda, MD USA USA [email protected] [email protected]
HARTMUT M. RABES VICTOR G. PRIETO Institute of Pathology Department of Pathology University of Munich The University of Texas M.D. Anderson Cancer Center Munich Houston, TX Germany USA [email protected] [email protected]
DIRK RADES KEVIN M. PRISE Department of Radiation Oncology Centre for Cancer Research and Cell Biology University Hospital Schleswig-Holstein Queen’s University Belfast Campus Luebeck Belfast Germany UK [email protected] [email protected] JERALD P. R ADICH Clinical Research Division KATHY PRITCHARD-JONES Fred Hutchinson Cancer Research Center Institute of Cancer Research/Royal Marsden Hospital Seattle, WA Sutton, Surrey USA UK [email protected] [email protected]
NORMAN S. RADIN AMANDA H. PROWSE Department of Psychiatry Nuffield Department of Obstetrics and Gynaecology University of Michigan Oxford University Ann Arbor, MI John Radcliffe Hospital USA Oxford [email protected] UK [email protected] FULVIO DELLA RAGIONE Department of Biochemistry and Biophysics CHING-HON PUI Second University of Naples St. Jude Children’s Research Hospital Naples Memphis, TN Italy USA [email protected] [email protected] RYAN L. RAGLAND Department of Human Genetics KAREN PULFORD University of Michigan Department of Clinical Laboratory Sciences Ann Arbor, MI University of Oxford, John Radcliffe Hospital USA Oxford [email protected] UK [email protected] AYYAPPAN K. RAJASEKARAN Department of Pathology and Laboratory Medicine TERESA GÓMEZ DEL PULGAR University of California Instituto de Investigaciones Biomedicas Los Angeles, CA CSIC, Madrid USA Spain [email protected] lxvi List of Contributors
SIGRID A. RAJASEKARAN MIRA R. RAY Department of Pathology and Laboratory Medicine Department of Urologic Sciences University of California The Prostate Centre at Vancouver General Hospital Los Angeles, CA Vancouver, BC USA Canada [email protected] [email protected]
ROGER REDDEL JAYADEV RAJU Children’s Medical Research Institute Toxicology Research Division, Bureau of Chemical Safety Westmead, NSW Food Directorate, HPFB, Health Canada Australia Ottawa, ONT [email protected] Canada [email protected] MAY REED Department of Medicine, Division of Geriatric Medicine S. RAMAKRISHNAN University of Washington Department of Pharmacology Seattle, WA University of Minnesota USA Minneapolis, MN [email protected] USA [email protected] EDUARDO M. REGO Medical School of Ribeirão Preto University of São Paulo KOTA V. R AMANA Ribeirão Preto Dept of Biochemistry and Molecular Biology Brazil University Of Texas Medical Branch [email protected] Galveston, TX USA REUVEN REICH [email protected] Department of Pharmacology, School of Pharmacy, Faculty of Medicine SANTIAGO RAMÓN Y CAJAL The Hebrew University of Jerusalem Department of Pathology, Vall d’ Hebron University Hospital Jerusalem Barcelona Israel Spain [email protected] [email protected] JEAN-MARIE REIMUND Service d’Hépato-Gastro-Entérologie et Nutrition, Centre GIORGIA RANDI Hospitalier Universitaire de Caen Department of Epidemiology Université de Caen-Basse Normandie Institute for Farmacological Research Mario Negri Caen Milan France Italy [email protected] [email protected]
CELSO A. REIS MARIUSZ Z. RATAJCZAK Institute of Molecular Pathology and Immunology of the Stem Cell Institute at James Graham Brown Cancer Center University of Porto University of Louisville Medical Faculty of Porto Louisville, KY Porto USA Portugal [email protected] [email protected]
LING REN ANKE RATTENHOLL National Cancer Institute, Center for Cancer Research Department of Dermatology Pediatric Oncology Branch University of Münster Bethesda, MD Münster USA Germany [email protected] [email protected]
ANDREW G. RENEHAN ALBERTO RAVAIOLI Department of Surgery Department of Oncology University of Manchester Infermi Hospital Christie Hospital NHS Foundation Trust Rimini Manchester Italy UK [email protected] [email protected] List of Contributors lxvii
MARCUS RENNER CARRIE RINKER-SCHAFFER Division of Molecular Genome Analysis, DKFZ Department of Surgery, Section of Urology Heidelberg The University of Chicago Germany Chicago, IL [email protected] USA [email protected] PAUL S. RENNIE The Richard Ivey School of Business University of Western Ontario TADEUSZ ROBAK London, ONT Department of Hematology Canada Medical University of Lodz [email protected] Lodz Poland DOMENICO RIBATTI [email protected] Department of Human Anatomy and Histology University of Bari Medical School FREDIKA M. ROBERTSON Bari The University of Texas MD Anderson Cancer Center Italy Houston, TX [email protected] USA [email protected] RAUL C. RIBEIRO Department of Oncology St. Jude Children’s Research Hospital CRISTINA RODRÍGUEZ Memphis, TN National Cancer Institute of Research (CNIO) USA Madrid [email protected] Spain
DES R. RICHARDSON JOSE LUIS RODRÍGUEZ-FERNÁNDEZ Department of Pathology Departamento de Fisiología Celular y Molecular University of Sydney Centro de Investigaciones Biológicas NSW, Australia Madrid [email protected] Spain [email protected] ANN RICHMOND Department of Cancer Biology Vanderbilt University Medical School CARLOS RODRIGUEZ-GALINDO Nashville, TN Department of Oncology USA St. Jude Children’s Research Hospital [email protected] Memphis, TN USA VICTORIA M. RICHON [email protected] Merck Research Laboratories Boston, MA USA DEREK LE ROITH [email protected] Division of Endocrinology, Diabetes and Bone Diseases Departmant of Medicine JUSTIN L. RICKER Mount Sinai School of Medicine Merck Research Laboratories New York, NY Upper Gwynedd, PA USA USA [email protected]
THOMAS RIED WOLF C. ROLAND Genetics Branch, Center for Cancer Research, National Biomedical Research Centre Cancer Institute, NIH University of Dundee Bethesda, MD Dundee USA UK [email protected] [email protected]
MAARTJE C. VAN RIJK Department of Surgery ZE’EV RONAI The Netherlands Cancer Institute Signal Transduction Program Antoni van Leeuwenhoek Hospital Burnham Institute for Medical Research Amsterdam La Jolla, CA The Netherlands USA [email protected] [email protected] lxviii List of Contributors
LUCA RONCUCCI LUCA RUBINO Department of Medicine Department of Immunology University of Modena and Reggio Emilia Fondazione Humanitas per la Ricerca Modena Rozzano, Milan Italy Italy [email protected] [email protected]
IGOR B. RONINSON MARCO RUGGIERO Department of Molecular Genetics Department of Experimental Pathology and Oncology University of Illinois at Chicago University of Firenze Chicago, IL Firenze USA Italy [email protected] [email protected]
ELIOT M. ROSEN ZORAN RUMBOLDT Long Island Jewish Medical Center Head and Neck Tumor Program Albert Einstein College of Medicine Hollings Cancer Center Bronx, NY Medical University of South Carolina USA Charleston, SC [email protected] USA
CAROL L. ROSENBERG Boston Medical Center and Boston University School of THOMAS M. RÜNGER Medicine Department of Dermatology Boston, MA Boston University School of Medicine USA Boston, MA [email protected] USA [email protected]
STEVEN A. ROSENZWEIG Department of Cell and Molecular Pharmacology and ERKKI RUOSLAHTI Experimental Therapeutics Vascular Mapping Center, Burnham Institute for Medical Medical University of South Carolina Research at University of California Charleston, SC Santa Barbara, CA USA USA [email protected] [email protected]
ANGELO ROSOLEN DARIO RUSCIANO Department of Pediatrics, Hemato-oncology Unit Friedrich Miescher Institute University of Padua Basel Padova Switzerland Italy [email protected] [email protected]
GIANDOMENICO RUSSO JEFFREY S. ROSS Istituto Demopatico dell’Immacolata Albany Medical College Instituto di Ricovero e Cura a Carattere Scientifico Albany, NY Roma, Italy USA [email protected] [email protected]
THEODORA S. ROSS IRMA H. RUSSO Department of Internal Medicine Breast Cancer Research Laboratory University of Michigan Fox Chase Cancer Center Ann Arbor, MI Philadelphia, PA USA USA [email protected] [email protected]
ALBERTO RUANO-RAV I NA JOSE RUSSO Department of Preventive Medicine and Public Health Breast Cancer Research Laboratory University of Santiago de Compostela Fox Chase Cancer Center C/San Francisco Philadelphia, PA Spain USA [email protected] [email protected] List of Contributors lxix
J. RYAN TOSHIYUKI SAKAI Head and Neck Tumor Program Department of Molecular-Targeting Cancer Prevention, Hollings Cancer Center Graduate School of Medical Science Medical University of South Carolina Kyoto Prefectural University of Medicine Charleston, SC Kyoto USA Japan [email protected]
JAMES T. RUTKA BODOUR SALHIA The Arthur and Sonia Labatt Brain Tumour Research Centre Cancer and Cell Biology Division The Hospital for Sick Children The Translational Genomics Research Institute The University of Toronto Phoenix, AZ Toronto, ONT USA USA [email protected] [email protected]
HELMUT RAINER SALIH ANNE THOUSTRUP SABER Department of Internal Medicine II National Research Centre for the Working Environment University Hospital of Tuebingen Copenhagen Eberhard-Karls-University Denmark Tuebingen [email protected] Germany [email protected]
GAURI SABNIS BETH A. SALMON University of Maryland School of Medicine Department of Pharmacology and Therapeutics Baltimore, MD University of Florida USA Gainesville, FL [email protected] USA [email protected] MOHAMAD SEYED SADR Brain Tumour Research Centre, Montreal Neurological HOWARD W. SALMON Institute, McGill University Department of Radiation Oncology Montreal, QC North Florida Radiation Oncology Canada Gainesville, FL [email protected] USA [email protected]
STEPHEN SAFE RAED SAMARA Department of Veterinary Physiology and Pharmacology Cancer Vaccine Branch, National Cancer Institute Texas A&M University National Institutes of Health College Station, TX Bethesda, MD USA USA [email protected] [email protected]
XAVIER SAGAERT JULIAN R. SAMPSON Department of Pathology Institute of Medical Genetics University Hospitals of K.U. Leuven Cardiff University Leuven Heath Park, Cardiff Belgium UK [email protected] [email protected]
MANORANJAN SANTRA ASIM SAHA Neurology Research University of Cincinnati and The Barrett Cancer Center Henry Ford Health System Cincinnatti, OH Detroit, MI USA USA [email protected] [email protected]
KUNAL SAIGAL FRANK SARAN National Institute on Deafness and Other Communication Department of Radiotherapy and Paediatric Oncology Disorders and National Cancer Institute NIH Royal Marsden Hospital NHS Foundation Trust Bethesda, MD Sutton, Surrey USA UK [email protected] [email protected] lxx List of Contributors
DEVANAND SARKAR RON H. N. VA N SCHAIK Departments of Urology, Pathology and Neurosurgery Department of Clinical Chemistry Columbia University Medical Center Erasmus University Medical Center College of Physicians and Surgeons Rotterdam New York, NY The Netherlands USA [email protected] [email protected]
MANFRED SCHARTL FAZLUL H. SARKAR Biozentrum, Universität Würzburg Karmanos Cancer Institute Würzburg Wayne State University Germany Detroit, MI [email protected] USA [email protected] HUUB SCHELLEKENS DEBASHIS SARKER Department of Innovation Studies Cancer Research UK Center for Cancer Therapeutics Central Laboratory Animal Institute The Institute of Cancer Research Utrecht University, TD Utrecht Sutton, Surrey The Netherlands UK [email protected] [email protected]
DETLEV SCHINDLER STEPHANIE SASSE Department of Human Genetics Hematology and Oncology University of Wurzburg University Hospital of Cologne, Department of Internal Wurzburg, Germany Medicine I [email protected] Cologne Germany [email protected] PETER M. SCHLAG Klinik für Chirurgie und Chirurgische Onkologie LEONARD A. SAUER Robert Rössle-Klinik, Charité Bassett Research Institute Berlin-Buch Cooperstown, NY Germany USA [email protected] [email protected]
MARTIN SCHLUMBERGER CHRISTOBEL SAUNDERS Institut de Cancérologie Gustave-Roussy, Villejuif School of Surgery and Pathology, QEII Medical Centre and Université Paris-Sud 11, Paris University of Western Australia France Crawley, WA [email protected] Australia [email protected] PETER SCHMEZER CONSTANCE L. L. SAW Division of Toxicology and Cancer Risk Factors Department of Pharmacy German Cancer Research Center (DKFZ) National University of Singapore Heidelberg Singapore Germany [email protected] [email protected]
ANURAG SAXENA ANNETTE SCHMITT-GRAEFF Department of Pathology and Laboratory Medicine Institute of Pathology Royal University Hospital, Saskatoon Health Region/ University Hospital Freiburg University of Saskatchewan Freiburg Saskatoon, Saskatchewan Germany Canada [email protected] [email protected]
REINHOLD SCHÄFER DOMINIK T. SCHNEIDER Molecular Tumor Pathology Clinic of Pediatrics Institute of Pathology Klinikum Dortmund Berlin Dortmund Germany Germany [email protected] [email protected] List of Contributors lxxi
STEFAN W. SCHNEIDER MARKUS SCHWAIGER Department of Dermatology Department of Nuclear Medicine University of Münster Technical University of Munich Münster Munich Germany Germany [email protected] [email protected]
SUSANNE SCHNITTGER EDWARD L. SCHWARTZ MLL Munich Leukemia Laboratory Department of Oncology Munich Albert Einstein College of Medicine Germany Bronx, NY [email protected] USA [email protected] NATHALIE SCHOLLER Center for Research on Early Detection and Cure of Ovarian DIETRICH VON SCHWEINITZ Cancer, School of Medicine University of Pennsylvania Universitäts-Kinderspital beider Basel (UKBB) Biomedical Research Building (BRB) II/III Basel Philadelphia, PA Switzerland USA [email protected] BÉATRICE SECRETAN IARC/WHO, Group Carcinogen Identification and AXEL H. SCHÖNTHAL Evaluation University of Southern California Lyon Cedex Keck School of Medicine France Los Angeles, CA [email protected] USA [email protected] RONY SEGER Department of Biological Regulation YVONNE M. SCHRAGE Weizmann Institute of Science Department of Pathology Rehovot Leiden University Medical Center Israel Leiden [email protected] The Netherlands [email protected] GAIL M. SEIGEL Department of Ophthalmology H. W. BART SCHREUDER University at Buffalo Department of Orthopaedics Buffalo, NY Radboud University Medical Centre USA Nijmegen [email protected] The Netherlands [email protected] HIROYUKI SEIMIYA Division of Molecular Biotherapy, Cancer Chemotherapy LAURA W. SCHRUM Center Department of Biology Japanese Foundation for Cancer Research The University of North Carolina at Charlotte Koto-ku, Tokyo Charlotte, NC Japan USA [email protected] [email protected] PAULE SEITE WOLFGANG A. SCHULZ Pôle Biologie Santé Department of Urology University of Poitiers Heinrich-Heine University Poitiers cedex Düsseldorf France Germany [email protected] [email protected] HELMUT K. SEITZ MANFRED SCHWAB Department of Medicine Tumour Genetics Salem Medical Center, Heidelberg, Center of Alcohol German Cancer Research Center, DKFZ Research Liver Disease and Nutrition and University of Heidelberg Heidelberg Germany Heidelberg, Germany [email protected] [email protected] lxxii List of Contributors
WILLIAM R. SELLERS JOHN F. SEYMOUR Harvard Medical School Peter MacCallum Cancer Center Dana-Farber Cancer Institute and the University of Melbourne Boston, MA Melbourne, VIC USA Australia [email protected] [email protected]
RABIA KSHAHID PERIASAMY SELVARAJ Saskatoon Cancer Center Department of Pathology University of Saskatchewan Emory University School of Medicine Saskatoon, SK Atlanta, GA Canada USA [email protected] [email protected] GIRISH V. S HAH Department of Pharmacology MARIE G. SELZER Department of Urology, Cell Biology and Anatomy University of Louisiana College of Pharmacy Sylvester Comprehensive Cancer Center, University of Monroe, LA Miami Miller School of Medicine USA Miami, FL [email protected] USA [email protected] A. SHARMA Head and Neck Tumor Program Hollings Cancer Center SUBRATA SEN Medical University of South Carolina Department of Molecular Pathology (Unit 951) Charleston, SC The University of Texas, M.D. Anderson Cancer Center USA Houston, TX USA RICKY A. SHARMA [email protected] Radiation Oncology and Biology University of Oxford Churchill Hospital VITALYI SENYUK Oxford Department of Medicine (M/C 737), College of Medicine UK Research Building [email protected] University of Illinois at Chicago Chicago, IL JERRY W. SHAY USA University of Texas [email protected] Southwestern Medical Center Dallas, TX USA NEDIME SERAKINCI [email protected] Anatomy and Neurobiology Institute of Medical Biology SHIJIE SHENG University of Southern Denmark Department of Pathology, Wayne State University Odense School of Medicine Denmark Karmanos Cancer Institute [email protected] Detroit, MI USA CHRISTINE SERS [email protected] Institute of Pathology University Medicine Charité DONNA SHEWACH Berlin Department of Pharmacology Germany University of Michigan Medical School [email protected] Ann Arbor, MI USA [email protected] VIJAYASARADHI SETALURI Department of Dermatology IE-MING SHIH University of Wisconsin School of Medicine and Public Department of Pathology Health Sciences Johns Hopkins University School of Medicine Madison, WI Baltimore, MD USA USA [email protected] [email protected] List of Contributors lxxiii
KENTARO SHIKATA ANTONIO SICA Department of Environmental Medicine Department of Immunology Graduate School of Medical Sciences Fondazione Humanitas per la Ricerca Kyushu University Rozzano, Milan Fukuoka Italy Japan [email protected] [email protected] GENE P. S IEGAL YOSEF SHILOH Departments of Pathology, Cell Biology, and Surgery and the Sackler School of Medicine, Tel Aviv University Gene Therapy Center Tel Aviv, Israel University of Alabama at Birmingham [email protected] Birmingham, AL USA [email protected] HYUNSUK SHIM Department of Hematology/Oncology Winship Cancer Institute, Emory University DIETMAR W. SIEMANN Atlanta, GA Department of Radiation Oncology USA University of Florida [email protected] Gainesville, FL USA [email protected] YUTAKA SHIMADA Department of Surgery Graduate School of Medicine CHRISTINE L. E. SIEZEN Kyoto University National Institute of Public Health and Environment Kyoto Bilthoven Japan The Netherlands [email protected] [email protected]
ALEXANDRA C. SILVEIRA YONG-BEOM SHIN Department of Pathology and Comprehensive Cancer Center BioNanotechnology Research Center University of Alabama at Birmingham Korea Research Institute of Bioscience and Biotechnology Birmingham, AL Yuseong, Daejeon USA Republic of Korea [email protected] [email protected]
DIANE M. SIMEONE TOSHI SHIODA Department of Surgery Massachusetts General Hospital Center for Cancer Research University of Michigan Medical Center Charlestown, MA Ann Arbor, MI USA USA [email protected] [email protected]
JANET SHIPLEY HANS-UWE SIMON The Institute of Cancer Research, Sutton Department of Pharmacology Surrey University of Bern UK Bern, Switzerland [email protected] [email protected]
GIRJA S. SHUKLA AMRIK J. SINGH Department of Surgery, Vermont Comprehensive Cancer Department of Pathology Center, College of Medicine Harvard Medical School, Beth Israel Deaconess Medical University of Vermont Center Burlington, VT Boston, MA USA USA [email protected] [email protected]
ARTHUR SHULKES SHREE RAM SINGH Department of Surgery Mouse Cancer Genetics Program University of Melbourne, Austin Health National Cancer Institute at Frederick Melbourne, VIC Frederick, MD Australia USA [email protected] [email protected] lxxiv List of Contributors
VINEETA SINGH JOSEF SMOLLE School of Surgery and Pathology Department of Dermatology Sir Charles Gairdner Hospital, QEII Medical Centre Medical University Graz Nedlands, WA Graz Australia Austria [email protected] [email protected]
LILLIAN L. SIU Department of Medical Oncology and Hematology LYNN SNIDERHAN Robert and Maggie Bras and Family New Drug Development Department of Microbiology and Immunology Program University of Rochester Princess Margaret Hospital Rochester, NY Toronto, ONT USA Canada [email protected] [email protected]
ANITA SJÖLANDER ROBERT W. SOBOL Cell and Experimental Pathology, Department of Laboratory Department of Pharmacology Medicine University of Pittsburgh School of Medicine, Hillman Cancer Lund University, Malmo University Hospital Center, University of Pittsburgh Cancer Institute Malmo Pittsburgh, PA Sweden USA [email protected] [email protected]
J. SKONER ALEXANDER S. SOBOLEV Head and Neck Tumor Program Department of Molecular Genetics of Intracellular Transport Hollings Cancer Center Institute of Gene Biology Medical University of South Carolina Russian Academy of Sciences Charleston, SC Moscow USA Russia [email protected] KEITH SKUBITZ Division of Hematology, Oncology and Transplantation University of Minnesota Medical School GRAZIELLA SOLINAS Minneapolis, MN Department of Immunology USA Fondazione Humanitas per la Ricerca [email protected] Rozzano, Milan Italy CHRISTOPHER SLAPE [email protected] Genetics Branch, Center for Cancer Research National Cancer Institute, National Institutes of Health Bethesda, MD TOSHIYA SOMA USA Department of Surgery [email protected] Graduate School of Medicine Kyoto University KEIRAN S. M. SMALLEY Kyoto The Wistar Institute Japan Philadelphia, PA [email protected] USA [email protected] PAV EL SOUCEK LUBOMIR B. SMILENOV Group for Biotransformations, Center of Occupational Department of Radiation Oncology Medicine Columbia University National Institute of Public Health New York, NY Prague USA Czech Republic [email protected] [email protected]
BRUCE F. SMITH Scott-Ritchey Research Center THOMAS D. SOUTHGATE College of Veterinary Medicine Paterson Institute for Cancer Research Auburn University University of Manchester Auburn, AL Manchester USA UK [email protected] [email protected] List of Contributors lxxv
LORENZO SPAGGIARI M. SHARON STACK Department of Thoracic Surgery Northwestern University Medical School European Institute of Oncology Chicago, IL Milan USA Italy [email protected] [email protected] JAN A. STAESSEN Division of Lung Toxicology DAVID W. SPEICHER Department of Occupational and Environmental Medicine The Wistar Institute (T.S.N.) and the Studies Coordinating Centre (J.A.S.) Philadelphia, PA Division of Hypertension and Cardiovascular Rehabilitation USA Department of Cardiovascular Diseases [email protected] University of Leuven Leuven VALERIE SPEIRS Belgium Leeds Institute of Molecular Medicine [email protected] University of Leeds Leeds L. JOE STAFFORD UK Department of Pathology and Comprehensive Cancer Center [email protected] University of Alabama-Birmingham Birmingham, AL USA DIETMAR SPENGLER [email protected] Max-Panck-Institut für Psychiatrie München ERIC STANBRIDGE Germany Department of Microbiology and Molecular Genetics [email protected] University of California Irvine, CA USA PHILLIPPE E. SPIESS Department of Urologic Oncology [email protected] University of Texas M. D. Anderson Cancer Center BARRY STAYMATES Houston, TX Department of Pathology USA Henry Mayo Newhall Memorial Hospital [email protected] Valencia, CA USA CHRISTOPH SPRINGFELD [email protected] Department of Internal Medicine IV University of Heidelberg Hospital STACEY STEIN Heidelberg Center for Advanced Biotechnology and Medicine Germany UMDMJ – Robert Wood Johnson Medical School [email protected] Piscataway, NJ USA
LAKSHMAIAH SREERAMA MARTIN STEINHOFF Department of Chemistry Department of Dermatology St. Cloud State University University of Münster St. Cloud, MN Münster USA Germany [email protected] [email protected]
ALEXANDER STEINLE SATISH K. SRIVASTAVA Dept of Biochemistry and Molecular Biology Department of Immunology University Of Texas Medical Branch Institute for Cell Biology Galveston, TX Eberhard-Karls-University USA Tuebingen [email protected] Germany [email protected]
SUDHIR SRIVASTAVA CARSTEN STEPHAN Division of Cancer Prevention Department of Urology, Charité National Cancer Institute Universitätsmedizin Campus Charité Mitte Rockville, MD Berlin USA Germany [email protected] [email protected] lxxvi List of Contributors
PETER L. STERN BAOCUN SUN Cancer Research UK Immunology Group Department of Pathology Paterson Institute for Cancer Research Tianjin Cancer Hospital and Tianjin Cancer Institute Manchester, UK Tianjin [email protected] P.R of China [email protected] WILLIAM G. STETLER-STEVENSON Extracellular Matrix Pathology Section, Cell and Cancer DUXIN SUN Biology Branch Division of Pharmaceutics, College of Pharmacy National Cancer Institute The Ohio State University Bethesda, MD Columbus, OH USA USA [email protected] [email protected]
RICHARD G. STEVENS SHI-YONG SUN University of Connecticut Health Center Winship Cancer Institute Farmington, CT Emory University USA Atlanta, GA [email protected] USA [email protected] FREDA STEVENSON CRC Wessex Oncology Unit, Southampton General Hospital ZHIFU SUN and Tenovous Laboratory Department of Health Sciences Research Southampton University Hospital Trust Mayo Clinic College of Medicine Southampton Rochester, MN UK USA [email protected] WILLIAM P. S TEWARD Cancer Biomarkers and Prevention Group SAUL SUSTER Department of Cancer Studies, University of Leicester The Ohio State University Leicester Columbus, OH UK USA [email protected] [email protected]
CONSTANTINE A. STRATAKIS SRILATHA SWAMI Department of Pediatric Endocrinology Division of Endocrinology NICHD, NIH Department of Medicine, Stanford University School of Bethesda, MD Medicine USA Stanford, CA [email protected] USA [email protected] ALEX Y. S TRONGIN Burnham Institute for Medical Research RUSSELL SZMULEWITZ La Jolla, CA Department of Medicine, Section of Hematology/Oncology USA The University of Chicago [email protected] Chicago, IL USA GARNET SUCK [email protected] Health Sciences Authority Centre for Transfusion Medicine DAY TA Singapore Head and Neck Tumor Program [email protected] Hollings Cancer Center Medical University of South Carolina PAUL H. SUGARBAKER Charleston, SC Washington Cancer Institute, Washington Hospital Center USA Washington, DC [email protected] USA [email protected] DIRK TAEGER Berufsgenossenschaftliches Forschungsinstitut für MAXWELL SUMMERHAYES Arbeitsmedizin (BGFA) Roche Products Limited Institute of Ruhr University Bochum Welwyn Garden City Bochum UK Germany [email protected] [email protected] List of Contributors lxxvii
MASATOSHI TAGAWA MASAAKI TAMURA Division of Pathology Department of Anatomy and Physiology Chiba Cancer Center Research Institute Kansas State University Chiba, Chuo-ku Manhattan, KS Japan USA [email protected] [email protected]
YOSHIKAZU TAKADA TAKUJI TANAKA UC Davis School of Medicine Deaprtment of Oncologic Pathology Sacramento, CA Kanazawa Medical University USA Kanazawa [email protected] Japan [email protected]
AKIHISA TAKAHASHI Department of Biology DAVID S. P. TAN Nara Medical University School of Medicine Section of Medicine Kashihara, Nara Institute of Cancer Research, The Royal Marsden Hospital Japan London [email protected] UK [email protected]
TSUTOMU TAKAHASHI Laboratory of Molecular and Biochemical Toxicology DEAN G. TANG Graduate School of Pharmaceutical Sciences Department of Carcinogenesis, The University of Texas M.D Tohoku University Anderson Cancer Center Sendai Science Park-Research Division Japan Smithville, TX [email protected] USA [email protected]
YOSHIMI TAKAI NIZAR M. TANNIR Osaka University Graduate School of Medicine/Faculty Department of Genitourinary Medical Oncology of Medicine University of Texas M. D. Anderson Cancer Center Suita Houston, TX Japan USA [email protected] [email protected]
TAKASHI TAKATA WEIKANG TAO Department of Oral and Maxillofacial Pathobiology, Division Department of Cancer Research of Frontier Medical Science, Graduate School of Biomedical Merck Research Laboratories Sciences West Point, PA Hiroshima University USA Hiroshima [email protected] Japan [email protected] CHI TARN Department of Medical Oncology TAMOTSU TAKEUCHI Fox Chase Cancer Center Department of Pathology Philadelphia, PA Kochi Medical School USA Kochi [email protected] Japan [email protected] CLIVE R. TAYLOR Departments of Urology and Pathology CONSTANTINE S. TAM University of Southern California Keck School of Medicine The University of Texas MD Anderson Cancer Center Los Angeles, CA Houston, TX USA USA [email protected] [email protected] JENNIFER TAYLOR HARALD TAMMEN Committee on Cancer Biology Digilab BioVisioN GmbH The University of Chicago Hannover Chicago, IL Germany USA [email protected] [email protected] lxxviii List of Contributors
ANDREW R. TEE PANAYIOTIS A. THEODOROPOULOS Institute of Medical Genetics Department of Basic Sciences Cardiff University The University of Crete, School of Medicine Heath Park, Cardiff Heraklion, Crete UK Greece [email protected]
KARL-HEINZ THIERAUCH AYALEW TEFFERI Therapeutic Research Group Oncology Division of Hematology Bayer Schering Pharma AG Mayo Clinic College of Medicine Berlin Rochester, MN Germany USA [email protected] [email protected]
BIN TEAN TEH MEGAN N. THOBE Laboratory of Cancer Genetics University of Cincinnati College of Medicine Van Andel Research Institute Cincinnati, OH Grand Rapids, MI USA USA [email protected] [email protected]
GARETH J. THOMAS VIGGO VAN TENDELOO Institute of Cancer, Bart’s and the London School of Medicine Laboratory of Experimental Hematology and Dentistry Antwerp University Hospital Queen Mary University of London Edegem London Belgium UK [email protected] [email protected]
JOSEPH R. TESTA Fox Chase Cancer Center NATALIE THOMAS Philadelphia, PA Department of Biochemistry and Molecular Biology USA Monash University [email protected] Melbourne, VIC Australia JOHN THACKER [email protected] Medical Research Council Radiation and Genome Stability Unit PETER THOMAS Harwell, Oxfordshire Departments of Surgery and Biomedical Sciences UK Creighton University [email protected] Omaha, NE USA RAJESH V. T HAKKER [email protected] Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM), Churchill SVEN THOMS Hospital, Headington Department of Paediatrics and Paediatric Neurology Oxford University of Göttingen UK Göttingen [email protected] Germany [email protected] NICHOLAS B. LA THANGUE Division of Biochemistry and Molecular Biology ANDREW THORBURN Davidson Building University of Colorado at Denver and Health Sciences Center University of Glasgow Aurora, CO Glasgow USA UK [email protected] [email protected]
DAN THEODORESCU MAGNUS THÖRN Department of Urology Department of Surgery (MT) University of Virginia Karolinska Institutet Charlottesville, VA Stockholm USA Sweden [email protected] [email protected] List of Contributors lxxix
DERYA TILKI MASSIMO TOMMASINO Department of Urology Infections and Cancer Biology Group University Hospital Groβhadern International Agency for Research on Cancer Munich Lyon Germany France [email protected] [email protected]
DONALD J. TINDALL ANTONIO TONINELLO Department of Urology Research, Department of Department of Biochemical Sciences “A. Rossi Fanelli” Biochemistry and Molecular Biology Sapienza University of Rome Mayo Clinic College of Medicine Rome Rochester, Minnesota Italy USA [email protected] [email protected] JEFFREY A. TORETSKY UMBERTO TIRELLI Departments of Pediatric Hematology and Oncology National Cancer Institute Lombardi Comprehensive Cancer Center, Georgetown Aviano University Italy Washington DC, NW [email protected] USA [email protected] MARTIN TOBI Section of Gastroenterology JORGE R. TORO Detroit VAMC, Detroit MI National Institutes of Health USA Bethesda, MD [email protected] USA [email protected] PEIKERT TOBIAS Division of Pulmonary and Critical Care Medicine TIFFANY A. TRAINA Department of Internal Medicine Breast Cancer Medicine Service Mayo Clinic College of Medicine Department of Medicine Rochester Memorial Sloan-Kettering Cancer Center USA New York, NY [email protected] USA [email protected] PHILIP J. TOFILON Department of Interdisciplinary Oncology, Drug Discovery LUBA TRAKHTENBROT Program, H. Lee Moffitt Cancer Center and Research Institute Head of Molecular Cytogenetics Laboratory University of South Florida Institute of Hematology, The Chaim Sheba Medical Center Tampa, FL Tel Hashomer, Israel USA [email protected] [email protected] PIERRE-LUC TREMBLAY HENRIK TOFT SØRENSEN Le Centre de recherche en cancérologie de l’Université Laval Department of Clinical Epidemiology Québec, QC Aarhus University Hospital Canada Aarhus C [email protected] Denmark GREGORY J. TSAY MASAKAZU TOI Department of Medicine, Institute of Immunology Department of Surgery (Breast Surgery) Chung Shan Medical University Graduate School of Medicine, Kyoto University Taichung Bunkyo-ku, Kyoto Taiwan Japan [email protected] [email protected] APOSTOLIA-MARIA TSIMBERIDOU AMANDA EWART TOLAND Department of Investigational Cancer Therapeutics, Division Division of Human Cancer Genetics of Cancer Medicine The Ohio State University The University of Texas M. D. Anderson Cancer Center Columbus, OH Houston, TX USA USA [email protected] [email protected] lxxx List of Contributors
KUNIHIRO TSUCHIDA SPECKS ULRICH Division for Therapies against Intractable Diseases Division of Pulmonary and Critical Care Medicine Institute for Comprehensive Medical Science (ICMS) Department of Internal Medicine Fujita Health University Mayo Clinic College of Medicine Toyoake Rochester Japan USA [email protected] [email protected]
NOBUO TSUCHIDA NICK UNDERHILL-DAY Department of Molecular Cellular Oncology and School of Biosciences Microbiology University of Birmingham Tokyo Medical and Dental University Birmingham Bunkyo-ku UK Tokyo [email protected] Japan [email protected] ROSEMARIE A. UNGARELLI Boston Medical Center and Boston University School of MEHMET KEMAL TUR Medicine Department of Experimental Medicine and Immunotherapy Boston, MA Helmholtz Institute for Biomedical Engineering USA University Hospital RWTH Aachen [email protected] Aachen Germany ANTTI VAHERI [email protected] Haartman Institute University of Helsinki GREG TURENCHALK Helsinki Senior Bioinformatics Developer Finland 454 Life Sciences [email protected] Branford, CT KEDAR S. VAIDYA USA Department of Pathology and Comprehensive Cancer Center [email protected] University of Alabama at Birmingham Birmingham, AL ANDREW S. TURNELL USA Cancer Research UK Institute for Cancer Studies [email protected] The Medical School The University of Birmingham ILAN VAKNIN Birmingham The Lautenberg Center for General and Tumor Immunology UK The Hebrew University-Hadassah Medical School [email protected] Jerusalem Israel MICHELLE C. TURNER [email protected] McLaughlin Centre for Population Health Risk Assessment Institute of Population Health ANNE M. VAN BUSKIRK University of Ottawa Department of Surgery Ottawa, ON The Ohio State University Canada Colombus, OH [email protected] USA [email protected] THOMAS TÜTING Laboratory for Experimental Dermatology MICHAEL W. VAN DYKE Department of Dermatology Department of Molecular and Cellular Oncology University of Bonn The University of Texas M. D. Anderson Cancer Center Bonn Houston, TX Germany USA [email protected] [email protected]
SALVATORE ULISSE CARTER VAN WAES Department of Experimental Medicine National Institute on Deafness and Other Communication University of Rome-Sapienza Disorders and National Cancer Institute NIH Rome Bethesda, MD Italy USA [email protected] [email protected] List of Contributors lxxxi
GEORGE F. VANDE WOUDE MARCEL VERHEIJ Van Andel Research Institute Department of Radiotherapy Grand Rapids, MI The Netherlands Cancer Institute–Antoni van Leeuwenhoek USA Hospital [email protected] Amsterdam The Netherlands [email protected] WIM VANDEN BERGHE Lab of Eukaryotic Gene Expression LEGEST-University Gent MUKESH VERMA Gent Analytical Epidemiology Research Branch, Epidemiology Belgium and Genetics Research Program, Division of Cancer Control [email protected] and Population Sciences National Cancer Institute, Bethesda MD SAKARI VANHARANTA USA Department of Medical Genetics [email protected] Biomedicum Helsinki University of Helsinki Helsinki RAKESH VERMA Finland Antisoma Research Laboratories, St. George’s Hospital [email protected] Medical School London, UK [email protected] ROBERTA VANNI Department of Biomedical Science & Technology University of Cagliari SRDAN VERSTOVSEK Monserrato (CA), Italy MD Anderson Cancer Center [email protected] University of Texas Houston, TX USA JUDITH A. VARNER [email protected] Moores UCSD Cancer Center University of California San Diego RENÉ P. H. V ETH La Jolla, CA Department of Orthopaedics USA Radboud University Medical Centre [email protected] Nijmegen The Netherlands AIKATERINI T. VASILAKI [email protected] University Department of Surgery Royal Infirmary GJ VILLARES Glasgow Department of Cancer Biology UK The University of Texas, M.D. Anderson Cancer Center [email protected] Houston, TX USA PETER VAUPEL Institute of Physiology and Pathophysiology AKILA N. VISWANATHAN University of Mainz Brigham and Women’s/Dana-Farber Cancer Center Mainz, Germany Boston, MA [email protected] USA [email protected] GUILLERMO VELASCO Department of Biochemistry and Molecular Biology I KRIS VLEMINCKX School of Biology Department of Molecular Biology Complutense University Ghent University – VIB Madrid Ghent Spain Belgium [email protected] [email protected]
ASHOK R. VENKITARAMAN ISRAEL VLODAVSKY Hutchison/MRC Cancer Research Centre Department of Oncology Cambridge Hadassah Hospital, Jerusalem UK Israel [email protected] [email protected] lxxxii List of Contributors
MARTINA VOCKERODT DONGMEI WANG Department of Pediatrics I, Children’s Hospital Georgetown University Georg-August University of Goettingen Lombardi Comprehensive Cancer Center Goettingen Washington, DC Germany USA [email protected] [email protected]
CHARLES L. VOGEL GANG WANG Sylvester Cancer Center, School of Medicine Department of Neurology and Neuroscience University of Miami Weill Medical College of Cornell University Plantation, FL New York, NY USA USA [email protected] [email protected]
TILMAN VOGEL Department of Surgery JIANGHUA WANG Krankenhaus Maria Hilf Department of Pathology Mönchengladbach Baylor College of Medicine Germany Houston, TX [email protected] USA
ULLA VOGEL RONG-FU WANG National Research Centre for the Working Environment Departments of Pathology and Immunology København Ø Center for Cell and Gene Therapy Denmark Baylor College of Medicine [email protected] Houston, TX USA DANIEL D. VON HOFF [email protected] Arizona Cancer Center Tucson, AZ XIANG-DONG WANG USA Jean Mayer USDA Human Nutrition Research Center on [email protected] Aging at Tufts University Boston, MA ALIREZA VOSOUGH USA Department of Radiotherapy [email protected] Royal Marsden Hospital NHS Foundation Trust Sutton, Surrey UK XIANGHONG WANG [email protected] Department of Anatomy The University of Hong Kong CHRISTOPH WAGENER Hong Kong Institute of Clinical Chemistry China University Medical Center Hamburg Eppendorf [email protected] Hamburg Germany YU WANG [email protected] Department of Medicine and Genome Research Center University of Hong Kong SABINE WAGNER Hong Kong, China Department of Pediatrics [email protected] Klinik St. Hedwig, Krankenhaus der Barmherzigen Brüder Regensburg Germany PATRICK WARNAT [email protected] Department of Theoretical Bioinformatics German Cancer Research Center Heidelberg HÅKAN WALLIN National Research Centre for the Working Environment Germany København Ø [email protected] Denmark [email protected] KOUNOSUKE WATABE Department of Medical Microbiology, Immunology and Cell SUSAN E. WALTZ Biology Shriner’s Hospital for Children Southern Illinois University, School of Medicine Cincinnati, OH Springfield, IL USA USA [email protected] [email protected] List of Contributors lxxxiii
VALERIE M. WEAVER TANIA M. WELZEL Department of Surgery Division of Cancer Epidemiology and Genetics University of California National Cancer Institute San Francisco, CA National Institutes of Health USA Bethesda, MD [email protected] USA [email protected] SCOTT A. WEED Department of Neurobiology and Anatomy, Mary Babb CLAUDIA WENDEL Randolph Cancer Center Department of General Surgery West Virginia University University Hospital Münster Morgantown, WV Münster USA Germany [email protected] [email protected]
OLIVER WEIGERT TAMRA E. WERBOWETSKI-OGILVIE Department of Internal Medicine III McMaster Stem Cell and Cancer Research Institute University of Munich, Großhadern Hamilton, ON München Canada Germany [email protected] [email protected] FRANK WESTERMANN German Cancer Research Center EUGENE D. WEINBERG Biology and Medical Sciences Department of Tumour Genetics Indiana University Heidelberg Bloomington, IN Germany USA [email protected] [email protected] AINSLEY WESTON National Institute for Occupational Safety and health, CDC I. BERNARD WEINSTEIN Morgantown, WV Columbia University USA New York, NY [email protected] USA [email protected] LINDA C. WHELAN UCD School of Biomolecular and Biomedical Science ELLEN WEISBERG UCD Conway Institute Department of Medical Oncology University College Dublin Dana Farber Cancer Institute Dublin Boston, MA Ireland USA [email protected] [email protected]
ROBERT P. W HITEHEAD LAWRENCE M. WEISS Department on Medicine, Division of Hematology/Oncology Division of Pathology University of Texas Medical Branch City of Hope National Medical Center Galveston, TX Duarte, CA USA USA [email protected] [email protected]
THERESA L. WHITESIDE DANNY R. WELCH University of Pittsburgh Cancer Institute and University of Department of Pathology and Comprehensive Cancer Center Pittsburgh School of Medicine University of Alabama at Birmingham Pittsburgh, PA Birmingham, AL USA USA [email protected] [email protected] ANDREAS WICKI SARAH J. WELSH Department of Clinical-Biological Sciences, Centre of Harris Manchester College Biomedicine University of Oxford Institute of Biochemistry and Genetics, University of Basel Oxford Basel UK Switzerland [email protected] [email protected] lxxxiv List of Contributors
CAROL WICKING CHRISTIANE DE WOLF-PEETERS Institute for Molecular Bioscience Department of Pathology The University of Queensland University Hospitals of K.U. Leuven St Lucia, QLD Leuven Australia Belgium [email protected] [email protected]
EDWIN VAN WIJNGAARDEN C. M. WONG Department of Community and Preventive Medicine Department of Pathology University of Rochester School of Medicine and Dentistry The University of Hong Kong Rochester, NY Hong Kong USA [email protected] [email protected]
DORI C. WOODS ELIZABETH D. WILLIAMS Walther Cancer Research Center Cancer Metastasis Laboratory University of Notre Dame Monash Institute of Medical Research, Monash University Notre Dame, IN Clayton, VIC USA Australia [email protected] [email protected]
AUL ORKMAN JAMES P. W ILMOT P W Cancer Center Cancer Research UK Centre for Cancer Therapeutics University of Rochester Medical Center The Institute of Cancer Research Rochester, NY Sutton, Surrey USA UK [email protected]
OLA WINQVIST Department of Medicine (OW) THOMAS WORZFELD Karolinska Institutet Institute of Pharmacology, University of Heidelberg Stockholm Heidelberg Sweden Germany [email protected] [email protected]
OHN IERCE ISE J P W XIFENG WU Department of Applied Medical Sciences, Maine Center for Department of Epidemiology Toxicology and Environmental Health The University of Texas MD Anderson Cancer Center University of Southern Maine Houston, TX Portland, ME USA USA [email protected] [email protected]
GUANG-HUI XIAO OLAF WITT CCU Pediatric Oncology Fox Chase Cancer Center German Cancer Research Center Philadelphia, PA Heidelberg USA Germany [email protected] [email protected] JIANMING XU ISAAC P. W ITZ Department of Molecular and Cellular Biology Department of Cell Research and Immunology Baylor College of Medicine Tel Aviv University Houston, TX Tel Aviv, Israel USA [email protected] [email protected]
IDO WOLF TIAN XU Institute of Oncology and the Cancer Research Center, Chaim Professor and Vice Chair of Genetics Sheba Medical Center and the Sackler Faculty of Medicine Howard Hughes Medical Institute Tel Aviv University Yale University School of Medicine Tel Aviv New Haven, CT Israel USA [email protected] [email protected] List of Contributors lxxxv
JUDY W. P. YAM HELEN L. YIN Department of Pathology Department of Physiology The University of Hong Kong University of Texas Southwestern Medical Center Hong Kong Dallas, TX [email protected] USA [email protected] SHO-ICHI YAMAGISHI Division of Cardiovascular Medicine, Department of XIAO-MING YIN Medicine Department of Pathology Kurume University School of Medicine University of Pittsburgh School of Medicine Kurume Pittsburgh, PA Japan USA [email protected] [email protected]
MICHIKO YAMAMOTO ZHIMIN YIN Department of Respiratory Medicine College of Life Sicence Kitasato University School of Medicine Nanjing Normal University Sagamihara, Kanagawa Nanjing Japan People’s Republic of China [email protected] [email protected]
KENNETH W. YIP HAINING YANG Cancer Research Center of Hawaii Burnham Institute for Medical Research University of Hawaii La Jolla Honolulu, HI CA USA USA [email protected]
HONG YANG HARRY H. YOON Cancer Vaccine Branch, National Cancer Institute, National Sidney Kimmel Comprehensive Cancer Center at Johns Institutes of Health Hopkins Bethesda, MD Baltimore, MD USA USA [email protected] [email protected]
PING YANG JUNG-HWAN YOON Department of Health Sciences Research Department of Internal Medicine Mayo Clinic College of Medicine Seoul National University College of Medicine Rochester, MN Chongno-gu USA Seoul [email protected] South Korea [email protected]
MASAKAZU YASHIRO Department of Surgical Oncology KAZUHIRO YOSHIDA Osaka City University Graduate School of Medicine Department of Surgical Oncology Osaka Gifu University School of Medicine Japan Gifu [email protected] Japan [email protected]
NDREW EUDALL W. A Y TATSUSHI YOSHIDA Philips Institute of Oral and Craniofacial Molecular Biology Department of Molecular-Targeting Cancer Prevention Virginia Commonwealth University Graduate School of Medical Science Richmond, VA Kyoto Prefectural University of Medicine USA Kyoto [email protected] Japan
MAKSYM V. Y EZHELYEV ANAS YOUNES Winship Cancer Institute Department of Lymphoma and Myeloma Emory University M. D. Anderson Cancer Center Atlanta, GA Houston, TX USA USA [email protected] [email protected] lxxxvi List of Contributors
GRAEME P. Y OUNG LAURA P. Z ANELLO Flinders Cancer Control Alliance Department of Biochemistry Flinders University University of California-Riverside Adelaide, SA Riverside, CA Australia USA [email protected] [email protected]
XIAO YUAN UWE ZANGEMEISTER-WITTKE Research and Development Center, Wuhan Botanical Garden Department of Pharmacology Chinese Academy of Science University of Bern Wuhan, Hubei Bern, Switzerland People’s Republic of China [email protected] [email protected]
ANDREW C. W. ZANNETTINO IMVS Main Laboratory JIAN YU Adelaide, SA Departments of Pathology and Pharmacology Australia University of Pittsburgh Cancer Institute [email protected] University of Pittsburgh School of Medicine Pittsburgh, PA USA BERTON ZBAR [email protected] Laboratory of Immunobiology NIH – Frederick Frederick, MD USA YAN PING YU [email protected] Department of Pathology University of Pittsburgh Pittsburgh, PA HERBERT J. ZEH III USA University of Pittsburgh, Departments of Surgery and [email protected] Bioengineering, Pittsburgh, PA USA [email protected] YU YU Department of Pathology JASON A. ZELL University of Sydney Cancer Prevention Program NSW Division of Hematology/Oncology and Epidemiology Australia Department of Medicine [email protected] School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, CA ANTHONY PO-WING YUEN USA Division of Otorhinolaryngology [email protected] Department of Surgery, The University of Hong Kong Hong Kong, SAR DANFANG ZHANG China Department of Pathology [email protected] Tianjin Cancer Hospital and Tianjin Cancer Institute Tianjin P.R of China LEO R. ZACHARSKI [email protected] VA Hospital White River Junction VT HAO ZHANG USA The University of Texas M. D. Anderson Cancer Center [email protected] Houston, TX USA [email protected]
GERARD P. Z AMBETTI Department of Biochemistry HONG ZHANG St. Jude Children’s Research Hospital Biogen Idec Memphis, TN San Diego, CA USA USA [email protected] [email protected] List of Contributors lxxxvii
JI-HU ZHANG YUESHENG ZHANG Lead Discovery Center Roswell Park Cancer Institute Novartis Institute for Biomedical Research Buffalo, NY Cambridge, MA USA USA [email protected] [email protected] WEILING ZHAO JINPING ZHANG Department of Radiation Oncology and Brain Tumor Center Departments of Pathology and Immunology, Center for Cell of Excellence and Gene Therapy Wake Forest University School of Medicine Baylor College of Medicine Winston-Salem, NC Houston, TX USA USA [email protected]
GUANG-BIAO ZHOU LIN ZHANG State Key Laboratory for Medical Genomics, Biogen Idec Shanghai Institute of Hematology, Ruijin Hospital San Diego, CA School of Medicine Shanghai Jiao Tong University USA Shanghai, People's Republic of China [email protected] [email protected]
LIN ZHANG Departments of Pathology and Pharmacology ZENG B. ZHU University of Pittsburgh Cancer Institute Departments of Medicine, Pathology, Surgery, Obstetrics and University of Pittsburgh School of Medicine Gynecology and the Gene Therapy Center, Division of Pittsburgh, PA Human Gene Therapy USA University of Alabama at Birmingham [email protected] Birmingham, AL USA [email protected] RUIWEN ZHANG University of Alabama at Birmingham M. ZIGLER Birmingham, AL Department of Cancer Biology USA The University of Texas, M.D. Anderson Cancer Center [email protected] Houston, TX USA SHIWU ZHANG Department of Pathology MARGOT ZOELLER Tianjin Cancer Hospital and Tianjin Cancer Institute DKFZ Tianjin Heidelberg P.R of China Germany [email protected] [email protected]
MASSIMO ZOLLO XIN A. ZHANG Vascular Biology Center, Cancer Institute, and Departments Department of Genetics of Medicine and Molecular Sciences Faculty of Biotechnological Science Federico II, Naples University of Tennessee Health Science Center CEINGE, Biotecnologie Avanzate Memphis, TN Naples USA Italy [email protected] [email protected]
ENRIQUE ZUDAIRE XUEFENG ZHANG NCI Angiogenesis Core Facility, National Cancer Institute Beth Israel Deaconess Medical Center and Harvard Medical National Institutes of Health School Advanced Technology Center Boston, MA Gaithersburg, MD USA USA [email protected] [email protected]
YU-WEN ZHANG CARSTEN ZWICK Laboratory of Molecular Oncology Klinik für Innere Medizin I Van Andel Research Institute Universität des Saarlandes Grand Rapids, MI Homburg USA Germany [email protected] [email protected]