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Stewardship Report
Stewardship Report Presented to: The H Foundation December 2015 Our Appreciation Dear Friends of The H Foundation: The Robert H. Lurie Comprehensive Cancer Center of Northwestern University is deeply grateful for The H Foundation’s extraordinary support over the past 15 years. Since 2002, The H Foundation has raised and donated more than $3 million to advance research at the Lurie Cancer Center. In turn, the Lurie Cancer Center has been able to leverage these generous philanthropic funds into more than $50 million in private and government grants for cancer research projects that bridge basic science and clinical care. I am delighted to share this report featuring the faculty members who have received Bridge Awards, Pilot Awards, and other support during 2014-2015. Your giving continues to impact the investigations of our highly dedicated scientists as they work together to find a cure for cancer. Over the years, The H Foundation’s partnership has helped us to stimulate and enable creative, novel research that has led to fundamental new discoveries, accelerating progress towards achieving new diagnostics and treatments for cancer. At the Lurie Cancer Center, we are developing programs that bridge basic science and clinical care and that will establish Chicago as a global leader in the delivery of personalized cancer treatment. Established in 1974, the Lurie Cancer Center is recognized as one of just 45 National Cancer Institute (NCI)-designated “comprehensive” cancer centers in the country for its dedication to the highest standards of cancer research, patient care, education, and community outreach. Our center is a founding member of the National Comprehensive Cancer Network and the Big Ten Cancer Research Consortium. -
Development of a Genetic Multicolor Cell Labeling Approach for Neural
Development of a genetic multicolor cell labeling approach for neural circuit analysis in Drosophila Dafni Hadjieconomou January 2013 Division of Molecular Neurobiology MRC National Institute for Medical Research The Ridgeway Mill Hill, London NW7 1AA U.K. Department of Cell and Developmental Biology University College London A thesis submitted to the University College London for the degree of Doctor of Philosophy Declaration of authenticity This work has been completed in the laboratory of Iris Salecker, in the Division of Molecular Neurobiology at the MRC National Institute for Medical Research. I, Dafni Hadjieconomou, declare that the work presented in this thesis is the result of my own independent work. Any collaborative work or data provided by others have been indicated at respective chapters. Chapters 3 and 5 include data generated and kindly provided by Shay Rotkopf and Iris Salecker as indicated. 2 Acknowledgements I would like to express my utmost gratitude to my supervisor, Iris Salecker, for her valuable guidance and support throughout the entire course of this PhD. Working with you taught me to work with determination and channel my enthusiasm in a productive manner. Thank you for sharing your passion for science and for introducing me to the colourful world of Drosophilists. Finally, I must particularly express my appreciation for you being very understanding when times were difficult, and for your trust in my successful achieving. Many thanks to my thesis committee, Alex Gould, James Briscoe and Vassilis Pachnis for their quidance during this the course of this PhD. I am greatly thankful to all my colleagues and friends in the lab. -
2020 Program Book
PROGRAM BOOK Note that TAGC was cancelled and held online with a different schedule and program. This document serves as a record of the original program designed for the in-person meeting. April 22–26, 2020 Gaylord National Resort & Convention Center Metro Washington, DC TABLE OF CONTENTS About the GSA ........................................................................................................................................................ 3 Conference Organizers ...........................................................................................................................................4 General Information ...............................................................................................................................................7 Mobile App ....................................................................................................................................................7 Registration, Badges, and Pre-ordered T-shirts .............................................................................................7 Oral Presenters: Speaker Ready Room - Camellia 4.......................................................................................7 Poster Sessions and Exhibits - Prince George’s Exhibition Hall ......................................................................7 GSA Central - Booth 520 ................................................................................................................................8 Internet Access ..............................................................................................................................................8 -
Fish Fins Or Tetrapod Limbs
CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector MICHAEL . COATES LIMB EVOLUTION MICHAEL I. COATES LIMB EVOLUTION Fish fins or tetrapod limbs - a simple twist of fate? Comparisons between Hox gene expression patterns in teleost fins and tetrapod limbs are revealing new insights into the developmental mechanisms underlying the evolutionary transition from fin to limb. Phylogenetic trees represent nested patterns of develop- full breadth of the distal mesenchyme, coincident with mental diversification. Yet, until recently, attempts to link development of a 'digital arch' from which the digits will large-scale evolutionary morphological transformations form (see below, Fig 2c) [4]. Thus, HoxD expression to changes in ontogeny have yielded limited results. restriction is reoriented from an antero-posterior to a Explanations have usually characterized developmental proximo-distal axis [1,2]. HoxA expression, in contrast to evolution in terms of shifts in the relative timing of that of the HoxD members, shows no antero-posterior developmental events and alterations to gross embryonic restriction, and instead consists of a series of proximo- patterns, whether static or dynamic, instead of attempting distally nested bands spanning the entire bud (Fig.la). to identify changes affecting specific morphogenetic pro- cesses. But this situation is changing, largely because of The similarities and differences between the development rapid advances in the study of the genes that regulate of the tetrapod limb bud and that of the zebrafish fin bud development. Perhaps most significantly of all, after the are striking (Fig. lb). By comparison with limbs, fin bud initial interest that was inspired by the remarkably con- outgrowth ceases earlier; mesenchymal proliferation fin- served features of some of these developmental genes, ishes as the apical fin bud ectoderm transforms into a pro- research is now beginning to focus on their diversity. -
Kenro Kusumi
July 2021 CURRICULUM VITAE Kenro Kusumi ADDRESS Arizona State University Dean Office of the Dean Armstrong Hall, Suite 240 1100 S McAllister Ave. Tempe, AZ 85287-2501, USA Telephone: (480) 965-8065 School Director School of Life Sciences PO Box 874501 Tempe, AZ 85287-4501, USA Telephone: (480) 727-8993 email [email protected] webpage-faculty https://sols.asu.edu/people/kenro-kusumi webpage-lab http://kusumi.lab.asu.edu/ LinkedIn https://www.linkedin.com/in/kenro-kusumi-496aa967/ Twitter @kenrokusumi Wikipedia https://en.wikipedia.org/wiki/Kenro_Kusumi EDUCATION 1984-1988 A.B., magna cum laude, Biochemical Sciences Harvard College, Cambridge, MA Undergraduate Advisors: Dan Stinchcomb & Daniel P. Kiehart Thesis: Identification of a Cytoplasmic Myosin-Like Protein in the Nematode C. elegans 1988–1997 Division of Health Sciences and Technology Program Harvard Medical School/Massachusetts Institute of Technology Completed medical school years 1-2 and USMLE Step 1 Exam 1990-1997 Ph.D., Biology Massachusetts Institute of Technology, Cambridge, MA Graduate Advisor: Eric S. Lander (member, Nat’l Acad Sci) Thesis: Positional Cloning and Characterization of the Mouse Pudgy Locus 1997-1998 Research Scientist Whitehead Institute for Biomedical Research, Cambridge, MA Postdoctoral Mentor: Eric S. Lander (member, Nat’l Acad Sci) 1998–2000 Hitchings-Elion Fellow of the Burroughs Wellcome Fund National Institute for Medical Research, London, UK Postdoctoral Mentor: Robb Krumlauf (member, Nat’l Acad Sci) Kenro Kusumi FACULTY APPOINTMENTS 2001-2006 Assistant -
DEVELOPMENTAL BIOLOGY an Official Journal of the Society for Developmental Biology
DEVELOPMENTAL BIOLOGY An official journal of the Society for Developmental Biology AUTHOR INFORMATION PACK TABLE OF CONTENTS XXX . • Description p.1 • Audience p.1 • Impact Factor p.1 • Abstracting and Indexing p.2 • Editorial Board p.2 • Guide for Authors p.5 ISSN: 0012-1606 DESCRIPTION . Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, growth, homeostasis and regeneration in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals. Research Areas Include: Regulation of stem cells and regeneration Gene regulatory networks Morphogenesis and self organization Differentiation in vivo and in vitro (organoids) Growth factors and oncogenes Genetics and epigenetics of development Evolution of developmental control Analysis of development at the single cell level DB authors can choose among a selection of article types- research papers, short communications, technical reports, resource papers, reviews and perspectives - and benefit from academic editors who are practicing scientists, fast publication, no color figures or page charges, flexible publication (open access or subscription) and a vast readership with more than 3 million downloads a year. Subscription articles published in Developmental Biology will become accessible to non-subscribers 12 months after publication on ScienceDirect. SDB members benefit from immediate free online access to all published articles. For queries please contact our editorial office at [email protected] AUDIENCE . Cell and Developmental biologists. Focuses on: mechanisms of development, differentiation, and growth in animals and plants. IMPACT FACTOR . 2020: 3.582 © Clarivate Analytics Journal Citation Reports 2021 AUTHOR INFORMATION PACK 24 Sep 2021 www.elsevier.com/locate/ydbio 1 ABSTRACTING AND INDEXING . -
The LIM Adaptor Protein LMO4 Is an Essential Regulator of Neural Crest Development
Developmental Biology 361 (2012) 313–325 Contents lists available at SciVerse ScienceDirect Developmental Biology journal homepage: www.elsevier.com/developmentalbiology The LIM adaptor protein LMO4 is an essential regulator of neural crest development Stacy D. Ochoa, Sally Salvador, Carole LaBonne ⁎ Dept. of Molecular Biosciences; and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA article info abstract Article history: The neural crest (NC) is a population of multipotent stem cell-like progenitors that arise at the neural plate Received for publication 3 August 2011 border in vertebrates and migrate extensively before giving rise to diverse derivatives. A number of compo- Revised 18 October 2011 nents of the neural crest gene regulatory network (NC-GRN) are used reiteratively to control multiple steps Accepted 21 October 2011 in the development of these cells. It is therefore important to understand the mechanisms that control the Available online 18 November 2011 distinct function of reiteratively used factors in different cellular contexts, and an important strategy for doing so is to identify and characterize the regulatory factors they interact with. Here we report that the Keywords: Xenopus LIM adaptor protein, LMO4, is a Slug/Snail interacting protein that is essential for NC development. LMO4 Neural crest is expressed in NC forming regions of the embryo, as well as in the central nervous system and the cranial LIM placodes. LMO4 is necessary for normal NC development as morpholino-mediated knockdown of this factor Snail leads to loss of NC precursor formation at the neural plate border. Misexpression of LMO4 leads to ectopic ex- Slug pression of some neural crest markers, but a reduction in the expression of others. -
Ready, Go! 14 July 2011
Ready, go! 14 July 2011 general transcription factors reduces the number of steps required for productive transcription and allows cells to respond quickly to internal and external signals." Transcriptional control by RNA polymerase II (Pol II) is a tightly orchestrated, multistep process that requires the concerted action of a large number of players to successfully transcribe the full length of genes. For many years, the initiation of transcription-the assembly of the basal transcription machinery at the start site-was considered the rate- limiting step. "We know now that the elongation step is a major node for the regulation of gene expression," says Shilatifard. "In fact, we have shown that mislocated elongation factors are the The Super Elongation Complex (SEC) activates stalled RNA polymerase II in response to developmental and cause for pathogenesis of infant acute environmental cues. Credit: Courtesy of Dr. Ali lymphoblastic and mixed lineage leukemia." Shalitifard, Stowers Institute for Medical Research with permission of CSHL press. Mixed lineage leukemia is caused by a chromosomal translocation of the gene named MLL, resulting in its fusion to a seemingly random collection of other genes. Although the Just like orchestra musicians waiting for their cue, translocation partners don't share any obvious RNA polymerase II molecules are poised at the similarities, they all create potent leukemia-causing start site of many developmentally controlled hybrid genes. In an earlier study, Chengqi Lin, a genes, waiting for the "Go!"- signal to read their graduate student in Shilatifard's lab and first author part of the genomic symphony. An assembly of on the current study, had identified the novel Super transcription elongation factors known as Super Elongation Complex (SEC) as the common Elongation Complex, or SEC for short, helps denominator shared by all MLL-fusion proteins. -
Detecting Conserved Regulatory Elements with the Model Genome Of
Proc. Natl. Acad. Sci. USA Vol. 92, pp. 1684-1688, February 1995 Genetics Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes SAMUEL APARICIO*t, ALASTAIR MORRISONt, ALEX GOULDt, JONATHAN GILTHORPE§, CHITRITA CHAUDHURIt, PETER RIGBY§, ROBB KRUMLAUF*, AND SYDNEY BRENNER* *Molecular Genetics Unit, Department of Medicine, Addenbrookes Hospital, Cambridge CB2 2QQ, United Kingdom; iLaboratory of Developmental Neurobiology and §Laboratory of Eukaryotic Molecular Genetics at Medical Research Council National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, United Kingdom Contributed by Sydney Brenner, October 26, 1994 ABSTRACT Comparative vertebrate genome sequencing with a Mg2+ concentration of 1.5 mM final. A A2001 Sau3AI offers a powerful method for detecting conserved regulatory Fugu genomic library (1) was screened at high stringency with sequences. We propose that the compact genome of the teleost this probe by using the method of Church and Gilbert (9). A Fugu rubripes is well suited for this purpose. The evolutionary phage designated H26S6A1 was obtained after three rounds of distance of teleosts from other vertebrates offers the maxi- plaque purification that contained the Hoxb-4 gene. The re- mum stringency for such evolutionary comparisons. To illus- gion from an internalEcoRI restriction site to the A polylinker, trate the comparative genome approach forF. rubripes, we use approximately 11.4 kb, was subcloned and sequenced by the sequence comparisons between mouse and Fugu Hoxb-4 non- dideoxynucleotide method (10) on an ABI373A DNA se- coding regions to identify conserved sequence blocks. We have quencer according to the manufacturer's instructions. used two approaches to test the function of these conserved DNA Sequence Analysis. -
Linearity in Cell Signaling Pathways
Linearity in Cell Signaling Pathways Thesis by Harry Nunns In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California 2019 Defended January 11, 2019 ii © 2019 Harry Nunns ORCID: 0000-0002-9669-0039 All rights reserved iii ABSTRACT Accurate cellular communication is of paramount importance for the development, growth, and maintenance of multi-cellular organisms. Communication between cells is carried out by a highly conserved set of signaling pathways, whose dysregu- lation can lead to many diseases. The molecular details of these signaling pathways are now well-characterized, allowing researchers to investigate the emergent prop- erties that arise from the complex signaling networks. These properties often arise from counter-intuitive or paradoxical mechanisms, meaning that systems-level anal- ysis is necessary. Importantly, mathematical models have been constructed for many pathways that capture measured reaction rates and protein levels. These mathemat- ical models successfully recapitulate dynamic responses of each pathway. Here, I investigated the input-output response of the Wnt, MAPK/ERK, and Tgfβ pathways using analytical and numerical treatment of mathematical models. Using this ap- proach, I found that the distinct architectures of the three signaling pathways lead to a convergent behavior, linear input-output response. Specifically, mathematical analysis reveals that a futile cycle in the Wnt pathway, a kinase cascade coupled to feedback in the ERK pathway, and nucleocytoplasmic shuttling in the Tgfβ path- ways all yield linear signal transmission. I then verified this finding experimentally in the Wnt and ERK pathways. For the Wnt pathway, direct measurements of the input-output response reveal that β-catenin is linear with respect to Wnt co- receptor LRP5/6 activity up until receptor saturation. -
Inverted Formin 2 Regulates Intracellular Trafficking, Placentation
RESEARCH ARTICLE Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome Katherine Young Bezold Lamm1,2,3,4*, Maddison L Johnson5, Julie Baker Phillips5, Michael B Muntifering4, Jeanne M James6, Helen N Jones3, Raymond W Redline7, Antonis Rokas5, Louis J Muglia1,2,8* 1Center for the Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States; 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States; 3Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States; 4Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States; 5Department of Biological Sciences, Vanderbilt University, Nashville, United States; 6The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States; 7Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, United States; 8Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States Abstract Healthy pregnancy depends on proper placentation—including proliferation, differentiation, and invasion of trophoblast cells—which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin -
FGF Mediated MAPK and PI3K/Akt Signals Make Distinct Contributions to Pluripotency and the Establishment of Neural Crest Lauren Geary1, Carole Labonne1,2*
RESEARCH ARTICLE FGF mediated MAPK and PI3K/Akt Signals make distinct contributions to pluripotency and the establishment of Neural Crest Lauren Geary1, Carole LaBonne1,2* 1Department of Molecular Biosciences, Northwestern University, Evanston, United States; 2Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, United States Abstract Early vertebrate embryos possess cells with the potential to generate all embryonic cell types. While this pluripotency is progressively lost as cells become lineage restricted, Neural Crest cells retain broad developmental potential. Here, we provide novel insights into signals essential for both pluripotency and neural crest formation in Xenopus. We show that FGF signaling controls a subset of genes expressed by pluripotent blastula cells, and find a striking switch in the signaling cascades activated by FGF signaling as cells lose pluripotency and commence lineage restriction. Pluripotent cells display and require Map Kinase signaling, whereas PI3 Kinase/Akt signals increase as developmental potential is restricted, and are required for transit to certain lineage restricted states. Importantly, retaining a high Map Kinase/low Akt signaling profile is essential for establishing Neural Crest stem cells. These findings shed important light on the signal- mediated control of pluripotency and the molecular mechanisms governing genesis of Neural Crest. DOI: https://doi.org/10.7554/eLife.33845.001 *For correspondence: [email protected] Competing interests: The Introduction authors declare that no The evolutionary transition from simple chordate body plans to complex vertebrate body plans was competing interests exist. driven by the acquisition of the Neural Crest, a unique stem cell population with broad, multi-germ Funding: See page 17 layer developmental potential (Le Douarin and Kalcheim, 1999; Hall, 2000; Bronner and LeDouarin, 2012; Prasad et al., 2012).