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P. 8 P. 7 P. 4 P. 3 2013 XXIV WEDNESDAY PAGE NETHERLANDS CONGRESS JULY 3 1 ISTH2013NEWS p. 3 p. 4 p. 7 p. 8 TISSUE FACTOR PATHWAY ISTH 2015 ToRONTO CONGRESS WOMEN’S ISSUES OPTIMISING ANTIcoAGULATION INHIBITOR AND PROTEIN S » OVERVIEW WITH SAM SCHULMAN » IN THROMBOSIS » IN THE ELDERLY » Tweet of the day #ISTH2013 Jane Skov @JaneSkov1 ImpressiveplenarytalkbyDenise Wagnerat#ISTH2013including amazingpicturesofneutrophils castingtheirNETs RecIPIENTS OF THE BIENNIAL AwARDS FOR CONTRIBUTIONS TO HEMOSTASIS (BACH) Initiated in 1982, the BACH Awards recognize individuals who have made significant contributions to research and education in blood coagulation. The awards are presented in two categories: • The Investigator Recognition Awards recognize ISTH members whose accomplishments are internationally regarded as exemplary models of excellence in research and teaching. • The Distinguished Career Awards recognize ISTH members whose ca- reer contributions have significantly advanced the scientific community’s understanding of the diseases and AT THIS EDITION OF THE ISTH congRESS PAPERLESS disorders affecting hemostasis. 2013 Awards conFERENCING HAS REALLY TAKEN OFF. DistinguishedCareer • Lawrence Brass, MD, PhD • Philip G de Groot, PhD At this edition of the ISTH congress of innovation of the ISTH 2013 congress ISTH congress visitor Elena Salabeno • Marcel Levi, MD, PhD paperless conferencing has really taken Tilman Hackeng is very satisfied with the from Italy agrees with him and adds: • Peter Newman, PhD off. Paper posters have completely been overwhelming atmosphere in the central “These electronic poster presentations • Zaverio Ruggeri, MD replaced by electronic poster boards, e-poster hall and says: “This is just what are fantastic. I had a large attendance facilitating a more attractive visualiza- we expected. E-posters provide a plat- when showing my poster and everybody InvestigatorRecognition tion of research results and enabling form for better interaction between the was able to clearly see my graphs • Wolfgang Bergmeier, MD video animation and interactive features presenter and those who are interested and photographs.”. • Christian Gachet, MD, PhD on posters. During the manned poster in the poster. Also, people can see every • Joseph Italiano, PhD sessions congress attendees can discuss poster any time during the congress, • Bernhard Nieswandt, PhD posters on the 74 poster boards while which is a great improvement compared AMC Disclaimer: • Thomas Renné, MD, PhD having a drink and some snacks. Director to temporary paper display. Third time http://www.amc.nl/disclaimer 2013 XXIV WEDNESDAY PAGE 2013 XXIV WEDNESDAY PAGE NETHERLANDS CONGRESS JULY 3 2 NETHERLANDS CONGRESS JULY 3 3 The Ratnoff-MacFarlane Plenary Lecture: THE ISTH’S JOURNAL HEMOPHILIA SOLUTIONS TISSUE FACTOR OF THROMBOSIS AND PATHWAY HEMOSTASIS (JTH) DEBUTS A NEW COVER INHIBITOR AND PROTEIN S As part of the excitement at this year’s Congress, the JTH unveiled its new, TAKE HOLD beautifully designed journal cover. This design will also be featured as part OF THE FUTURE of its year State-of-the-Art issue. The new cover features modern imagery, We are committed to helping people with updated branding and a crisp white hemophilia because at Hemophilia Solutions background that allows the artwork and by Bayer, we never lose sight of the human factor. wording to pop off the page and engage readers with ease. See the new journal cover at the JTH desk in the ISTH booth, 500, or online in July. RESEARCH MANAGE SUPPORT WHAT TO DO AND SEE IN AMSTERDAM-TOURISM TIPS Eat a raw herring You simply must try raw herring. We don’t want to hear any excuses. The best time Tilman. It is a pretty unusual first name. Only seven men and boys in the Netherlands ences to work as a research fellow at the Department of Biochemistry at the Maastricht to try one is between May and July when the new catch hits the stands. There’s are registered having “Tilman” as their official first name, according to the Dutch First University. In 2002 he received a prestigious mid-career grant from the Netherlands a quality fish stall or store around most corners. This fish is a bargain snack and Name Database of the Meertens Institute. It is actually a Frisian name (Friesland is a Organisation for Scientific Research (NWO). Currently, he is head of the Department of makes for an authentic Dutch eating experience. province in the north of the Netherlands) and, according to the always helpful Wiki- Biochemistry were he studies the anticoagulant protein C/protein S/TFPI pathways and pedia website, the strain is derived from the Oldfrisian word “til”, meaning good, fair applies total chemical protein synthesis to the development of peptide/protein-based Artistic icons in a serene setting or reliable. An appealing symbolic name to have when one is working in the field of contrast agents for imaging of cardiovascular disease. He is a board member of the The Hermitage Amsterdam is the Dutch branch of the world-famous Hermitage in biochemistry. It is also representative for the many contributions that the presenter of Cardiovascular Research Institute Maastricht (CARIM), and president of the Nether- St. Petersburg, Russia. Located on the banks of the Amstel River, the Hermitage today has made to the field of thrombosis and haemostasis. “The Ratnoff-MacFarlane lands Society on Thrombosis and Haemostasis. Amsterdam is a beautiful exhibition space and cultural education centre with a focus Bayer and the Bayer Cross are registered trademarks of Bayer. plenary lecture”, named after Drs Ratnoff and MacFarlane who are best known for © 2013 Bayer HealthCare Pharmaceuticals Inc. All rights reserved. on Russian history and culture. 04/13 G.SM.HEM.05.2013.0027 their discovery of the coagulation cascade, will be given by professor Tilman Hackeng Protein S, named after Seattle where it was first discovered, is a vitamin K-dependent HermitageAmsterdam|Amstel51|Opendaily10:00-17:00|www.hermitage.nl (Maastricht University, The Netherlands). protein that acts as a cofactor of the anticoagulant protein Activated Protein C (APC). However, protein S also exhibits anticoagulant activity in the absence of APC. In his Listen to the sounds of swing It is exactly 20 years ago (1993) that he defended his PhD thesis entitled “The protein lecture, Tilman will address what was originally described as “the APC-independent ac- Tonight, we’re taken back to the 1950s and the arrival of jazz in the venerable concert C pathway on endothelial cells” at the Utrecht University. Thereafter he left the Neth- tivity of protein S” and which was later uncovered to be a specific anticoagulant cofac- hall. American-born jazz vocalist and Grammy Award winner Kurt Elling follows in erlands to continue his career in the USA, where he worked as a Postdoctoral Fellow tor activity for Tissue Factor Pathway Inhibitor (TFPI) in the inhibition of factor Xa. After Frank Sinatra’s vocal steps with the Kurt Elling s(w)ings Frank Sinatra, emphasizing and later as a Senior Research Scientist at the Scripps Research Institute in La Jolla, an historical perspective, the inhibition of extrinsic tenase complex as well as the role the singer’s loose and free style. But Elling – a true jazz singer, one of the last of his CA. It is in these labs where his love for synthetic protein chemistry started. In 1998 he of platelet TFPI/protein S will be described. In addition the physiological importance of kind – is not an imitator: Sinatra’s interpretations are simply a starting point. came back to the Netherlands on a Fellowship for the Royal Academy of Arts and Sci- the TFPI/protein S anticoagulant pathway will be discussed. Concertgebouw|Concertgebouwplein10|Wednesday3July20:00|24to42Euros| www.concertgebouw.nl R E S WEDNESDAY JULY 3, 2013 | PROGRAM AT A GLANCE 08:00-09:30 Oral Communications Thrombus resolution and stroke G104-105 Tips & Funny facts about the Dutch “ I believe in innovation and the way you Contact activation G106-107 Coagulation and complement Elicium 1 Endothelial cells G104-105 Treatment of von Willebrand disease Forum get to innovation is you fund research Immune thrombocytopenic purpura Mondriaan II Major bleeding Auditorium How do you make and keep Dutch friends? and you learn the basic facts” Inhibitor development in haemophilia A Auditorium Venous thrombosis and cancer Elicium 2 It’s all in the body language plus a few natty lines. New acquaintances should be BILL GATES Modifications in factors VIII, IX and XI Emerald Clot structure E102 greeted with a handshake. As for longer-term friends, a 3-point kiss - that’s cheek- New developments in thrombus formation Elicium 2 Thrombosis and haemostasis in the Asian-Pacific Emerald to-cheek-to-cheek, is commonplace. When leaving a Dutch home, always part with Non-inherited risk factors for venous thrombosis Elicium 1 Thrombosis and haemostasis in the G106-107 a dag (day), or shout a more informal doei (bye). Hug/cuddle at your own peril. Novel platelet receptors Mondriaan III developing world Pregnancy and coagulation G102-103 Nurses symposium E108 LEKKER! Rare bleeding disorders - II E102 14:30-15:30 Oral Communications If you spend some time in the lowlands, you will definitely hear the word “lekker”. Recurrent venous thrombosis - II E104-107 Alternative treatments of haemophilia A Auditorium This seemingly innocent word is ubiquitous in the Netherlands. Thrombin generation tests Mondriaan IV Coagulation factor XIII G106-107 A R Von Willebrand factor – I Forum Coagulation factor: Structure and function G102-103 “Lekker” in its
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