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Complete List of Compounds Screened with the Primary Screening Assay Against Dengue Virus Infection

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SUPPLEMENTARY DATA Table 3: Complete List of Compounds Screened with the Primary Screening Assay against Dengue Virus infection. Percentage of Inhibition of Compounds DENV Infection Lapachone, - 98.84 Mycophenolic acid 92.38 Lycorine HCl 86.86 Ivermectin 84.62 C6 Ceramide 84.06 Anisomycin 82.49 Shikonin 78.94 Cycloheximide 78.71 Chelerythrine Cl 73.36 Skimmianine 61.96 Actinomycin D 59.60 Narasin 55.89 Rapamycin 55.12 Tunicamycin B 55.01 Acivicin 54.32 Cotinine, (-)- 52.71 Cantharidin 51.87 Epigallocatechin gallate 50.92 Gitoxigenin 49.01 Kainic acid 48.87 Brefeldin A 47.12 Dicoumarol 45.99 Diacetoxyscirpenol 45.55 Austricin 45.01 Valinomycin 43.34 Thapsigargin 42.90 Strophanthidin acetate 41.96 Trimethylpsoralen, 4,5',8- 41.86 Echinomycin 41.52 Chromomycin A3 40.87 Tryptanthrin 39.03 Sanguinarine 38.73 Songorine 38.09 Condelphine 37.45 Salinomycin 35.54 Phorbol 12,13-dibutyrate 35.35 Nigericin Na 34.02 Deoxyphorbol 13- phenylacetate 20-acetate, 12- 33.74 Desoxypeganine HCl 33.07 Usnic acid, (+)- 32.59 Quisqualic acid 32.13 Gossypol 31.17 Spectinomycin sulfate 30.71 Embelin 29.70 Phorbol 12-myristate 13- acetate 29.58 Tanshinone IIA 29.01 Methoxyluteolin, 6- 28.76 Veratridine 28.47 Sevedindione 28.18 Bicuculline, (+)- 26.81 Oligomycin A 26.75 Strychnine HCl 26.70 Carminic acid 26.67 Luteolin 25.92 Manool 25.59 Homoorientin 25.09 Radicicol 25.09 Tropine 24.50 3-B-Indoleacrylic acid 24.45 Baccatin III 24.40 Citreoviridin 23.71 Bavachinin A 23.50 Ryanodine 22.87 Vulpinic acid 22.42 Quinidine HCl 22.34 Heliotrine 22.01 Saponarin 21.61 Gambogic acid 21.60 Podocarpic acid 21.36 Digitoxin 21.35 Harringtonine 20.81 Myricetin 20.49 Retinoic acid, 9-cis- 20.14 Rotenone 20.07 Cinobufagin 19.81 Taxol 19.79 Atropine-N-oxide 18.92 Myristicin 18.74 Graveoline 17.97 Menadione 17.05 Quassin 16.98 Castanospermine 16.95 Piceatannol 16.58 Protopine HCl 16.52 Ouabain (-)- 16.41 Honokiol 16.37 Caffeic Acid 16.14 Maritimein 15.82 Cyclopamine 15.72 Bergenin 15.59 CAPE 15.49 Gelsemine HCl 15.40 Wedelolactone 15.28 Isorhoifoline 15.15 Tetrahydroalstonine 14.72 Apigenin 14.68 Fumonisin B2 14.62 Hypocrellin B 13.70 Colchicine 13.27 Berberine HCl 13.17 Datiscetin 13.02 Visnagin 12.65 Tomatidine 12.44 Rottlerin 12.23 Myricitrin 12.21 Diosmetine 12.15 Vinpocetine 11.99 Rubescensin A 11.92 Deacetylcolchicine, N-formyl- 11.59 Andrographolide 11.31 Epibatidine, (±)- 11.28 Oleanolic acid 11.19 Convolvamine HCl 11.14 Wortmannin 11.06 Deguelin 11.00 Ajmaline 10.85 Harmaline HCl 10.60 Dihydroergocristine mesylate 10.50 Chrysoeriol 10.44 Narirutin 10.43 Daunorubicin HCl 10.36 Magnolol 10.34 Emodin 10.16 Lysergol 10.01 Parthenolide 10.01 Monensin Na 9.87 Ingenol 3,20-dibenzoate 9.82 Hydroxyflavone, 7- 9.78 Kavain (+/-) 9.71 Dihydrotanshinone 9.69 Cerulenin 9.54 Australine HCl 9.46 Diosmin 9.25 Grayanotoxin III 9.15 Retinoic acid (all trans) 9.09 Bulleyaconitine A 8.99 Delcorine 8.74 Prostaglandin A1 8.55 Peganole 8.48 Ebelactone B 8.39 Deltaline 8.30 Solasodine 8.25 Deoxyphorbol 13-acetate, 12- 8.02 Tamarixetine 7.95 Yangonin 7.93 Dihydroxy-4'-methoxy- chalcone, 2',6'- 7.80 Genistein 7.74 Isorhamnetine-3-O-glucoside 7.73 Chaetomellic acid A 7.73 Betulinic acid 7.63 Remerine HCl 7.62 Antibiotic A-23187 7.53 Theobromine 7.30 Chrysine 7.29 Eriocitrin 7.21 Bromocriptine mesylate 6.93 Karakoline 6.77 Ginkgolide A 6.74 Naringenin 6.47 Geranylgeranoic acid 6.30 Sinomenine 6.28 Methysticin 5.97 Bromolaudanosine, (±)-6'- 5.90 Cyclopiazonic acid 5.89 Forskolin 5.78 Galanthamine HBr 5.77 Daidzin 5.63 Chelidonine, (+)- 5.57 Troleandomycin 5.50 Asarinin, (-)- 5.37 Lapiferine 5.36 Salsolinol HBr 5.34 Lincomycin 5.24 Oxocafestol, 16- 5.16 Daidzein 5.10 Sinensetine 5.09 Mimosine, L- 5.05 Mithramycin A 5.04 Piperine 5.03 Imperialine 4.80 Conessine 4.77 Isorhamnetine-3-O-rutinoside 4.75 Diacetylkorseveriline 4.69 Marein 4.66 Tubercidin 4.64 Andrographolide, dehydro- 4.61 Pratol 4.50 Euphorbiasteroid 4.48 Dihydroxyflavone, 6,7- 4.37 Ursolic acid 4.36 Apigenin-7-O-glucoside 4.30 Papaverine HCl 4.25 Xanthotoxin 4.19 Didymin 4.16 Boldine 4.13 Puromycin 3.97 Aucubin 3.92 Homatropine HBr 3.88 Neomycin sulfate 3.75 E-64 3.59 Scopolamine N-oxide HBr, (-)- 3.51 Veratramine 3.47 Matrine 3.44 Demethylepipodophyllotoxin, 4'- 3.33 Fisetin 3.33 Isovitexin 3.18 Domoic acid 3.05 Norharmane 2.93 Retinoic acid, 13-cis- 2.76 Sclareol 2.67 Scopolomine N-butylbromide 2.43 Bufalin 2.40 Kaempferol-7- neohesperidoside 2.17 Flavokawain B 2.14 Salsolidine 2.12 Silybine 1.98 Harmalol HCl 1.88 Carnosic acid 1.86 Lapidine 1.69 Formononetin 1.59 Vincristine sulfate 1.24 Decoyinine 1.23 Huperzine A, (-)- 1.23 GERI-BP002-A 0.90 Santonin 0.84 Oxokahweol, 16- 0.81 Glycyrrhetinic acid, 18-- 0.73 Eburnamonine, (-)- 0.61 Kaempferol-3-O-glucoside 0.58 Ginkgolide B 0.56 Kaempferol 0.52 Hydrocotarnine HBr 0.45 Himbacine 0.27 Vincamine 0.12 Amygdalin 0.11 Auraptene 0.08 Tschimganidin 0.00 Dubinidine 0.00 Etoposide 0.00 Myriocin 0.00 Phloretin 0.00 Prostaglandin F2 0.00 Coumermycin A1 0.00 Isoscopoletine 0.00 Atropine sulfate 0.00 Isosakuranetin 0.00 Cycloserine, L- 0.00 Curcumin 0.00 Yohimbine HCl 0.00 Laudanosoline HBr 0.00 Tschimganine 0.00 Homobutein 0.00 Oxytetracycline, -apo- 0.00 Monocrotaline 0.00 Perillic acid 0.00 Dihydromethysticin 0.00 Nitrarine 2HCl 0.00 Ungerine nitrate 0.00 Pinocembrin 0.00 Vitexin-2"-O-rhamnoside 0.00 Fumagillin 0.00 Aconitine 0.00 Isotetrandrine 0.00 Kanamycin 0.00 Methoxyflavone, 5- 0.00 Nicotine, (-)- 0.00 Citrinin 0.00 Rhoifolin 0.00 Kahweol 0.00 Pseudopelletierin HCl 0.00 Picrotoxinin 0.00 Sitosterol, - 0.00 C2 Phytoceramide 0.00 Prostaglandin B1 0.00 E-64-D 0.00 Harmine HCl 0.00 Rosmarinic acid 0.00 Baicalein 0.00 Cevadine 0.00 Kenpaulone 0.00 Gramine 0.00 Ketopinic acid 0.00 Taxifolin (+) 0.00 Sulfuretine 0.00 E-64-C 0.00 Cyclosporin A 0.00 Fillalbin 0.00 Brucine n-oxide 0.00 Catalpol 0.00 Heteratisine 0.00 Resveratrol 0.00 Norfluorocurarine 0.00 Rhamnetine 0.00 Artesunate 0.00 Harmol HCl 0.00 Butein 0.00 Penicillamine, L- 0.00 Robinetine 0.00 Aristolochic acid A 0.00 Genistin 0.00 Nonactin 0.00 Homoeriodictyol (-) 0.00 Morin 0.00 Pilocarpine HCl 0.00 Jervine 0.00 Trichodesmine 0.00 Prostaglandin E2 0.00 Picrotin 0.00 Quercetin 0.00 Luteolin-3',7-di-o-glucoside 0.00 Vinblastine sulfate 0.00 Hyoscyamine 0.00 Capsaicin 0.00 Rauwolscine 0.00 Naringenin-7-O-glucoside 0.00 Hernandezine 0.00 Prostaglandin E1 0.00 Indirubin 0.00 Swainsonine 0.00 Berbamine 2HCl 0.00 Rifampicin 0.00 Bilobalide 0.00 E6 Berbamine 0.00 Phorbol 12,13-dibutyrate, 4-- 0.00 Arecoline HBr 0.00 Feroline 0.00 Cytochalasin B 0.00 Quinine HCl 0.00 Amentoflavone 0.00 Sterigmatocystin 0.00 Eriodictyol 0.00 Eriodictyol-7-O-glucoside 0.00 Phorbol 12-myristate 13- acetate, 4-- 0.00 Phytosphingosine 0.00 Melatonin 0.00 Gingerol 0.00 Cytochalasin D 0.00 Cytochalasin E 0.00 Eudesmine 0.00 Camptothecin 0.00 Doxorubicin HCl 0.00 Mevastatin 0.00 Plumbagin 0.00 Ellipticine 0.00 Prostaglandin J2 0.00 Hydroxycamptothecin, 10- 0.00 Hypericin 0.00 Gliotoxin 0.00 Tetrandrine 0.00 Podophylotoxin 0.00 Rhapontin 0.00 Galangine 0.00 Ecdysone 0.00 Dipterocarpol 0.00 Stachydrine HCl 0.00 Seneciphylline 0.00 Streptonigrin 0.00 Ferulic acid 0.00 Bleomycin 0.00 Ellagic acid 0.00 Methylergonovine 0.00 Naringin 0.00 Sarsasapogenin 0.00 Scopoletin 0.00 Cafestol acetate 0.00 Quercitrin 0.00 Securinine 0.00 Silymarin 0.00 Tetrahydropapaverine 0.00 Aloe-emodine 0.00 Noreleagnine 0.00 Madecassic acid 0.00 Isocorydine HCl 0.00 Abscisic acid, (±)- 0.00 Mitomycin C 0.00 Isoquercitrine 0.00 Leucomisine 0.00 Cephradine 0.00 Khellin 0.00 Betulin 0.00 Gibberellic acid, (+)- 0.00 Vitexin 0.00 Demissidine 0.00 Catharanthine base 0.00 Corydaline 0.00 Schisandrin A, R(+)- 0.00 Capreomycin sulfate 0.00 Carnitine Cl, (±)- 0.00 Chartreusin 0.00 Zearalanol, - 0.00 Limonin 0.00 Lappaconitine 0.00 Dehydrokawain, 5,6- 0.00 Rifamycin SV-NA 0.00 Senecionine 0.00 Nalidixic acid 0.00 Lupinine 0.00 Geraldol 0.00 Chlorogenic acid 0.00 Sclerotiorin 0.00 Anabasine HCl 0.00 Antimycin A1 0.00 Brassinin 0.00 Asiatic acid 0.00 Indole-3-butyric acid 0.00 Lagochiline 0.00 Ferutinin 0.00 Friedelin 0.00 Panaxadiol 0.00 Rutaecarpine 0.00 Geniposide 0.00 Tetrahydrolipstatin 0.00 Pimaricin 0.00 Muscarine Cl, (+)- 0.00 Cotininecarboxylic acid, trans- 4- 0.00 Protoveratrine B 0.00 Cryptotanshinone 0.00 Vindoline 0.00 Griseofulvin, (+)- 0.00 Dehydrocostus Lactone 0.00 Salsoline 0.00 Amphotericin B 0.00 Hordenine sulfate 0.00 Sedanolide 0.00 Noscapine, (±)- 0.00 Physostigmine 0.00 Ecdysone, - 0.00 Phorbol 0.00 Kinetin 0.00 Evodiamine 0.00 Retrorsine 0.00 Flavokawain A 0.00 Bergapten 0.00 Dihydrorobinetin 0.00 Zearalenone 0.00 Flavanomarein 0.00 Artemisinin 0.00 Cinchonidine, (-)- 0.00 Hesperidine 0.00 Anisodamine 0.00 Neohesperidin 0.00 Coumestrol 0.00 Epicatechin, (-)- 0.00 Deoxyshikonin 0.00 Minocycline 0.00 Acacetine 0.00 Sclareolide, (3aR)-(+)- 0.00 Thymoquinone 0.00 Ingenol 0.00 Phlorizine 0.00 Arbutin 0.00 Cytisine, (-)- 0.00 Patulin 0.00 Schisandrin B, S(-)- 0.00 Hesperetine 0.00 Syringetine-3-O-glucoside 0.00 Cepharanthine 0.00 Schisantherin A 0.00 Dihydrolysergol, 9,10- 0.00 Lobeline HCl 0.00 Shikimic Acid 0.00 Indole-3-carbinol 0.00 Spartein sulfate (-)- 0.00 Trigonelline HCl 0.00 Peruvoside 0.00 Lavendustin A 0.00 Osthole 0.00 Ochratoxin A 0.00 Azomycin 0.00 Solanesol 0.00 Vinorelbine base 0.00 Indole-3-acetic acid 0.00 Cafestol 0.00 Caryophyllene oxide 0.00 Palmatine Cl 0.00 Catechin hydrate, (+)- 0.00 Vanillylacetone 0.00 Corynanthine 0.00 Hypocrellin A 0.00 Hirsutine 0.00 Biochanin A 0.00 Isorhamnetine 0.00 Harmane HCl 0.00 Rutin 0.00 Solanine, - 0.00 Diindolylmethane 0.00 Pinocembrin-7-methylether 0.00 Hydrastine, D-- 0.00 Lasalocid A Na 0.00 Hydroxytropinone, 6- 0.00 Cinchonine, (+)- 0.00 D-Tubocurarine-chloride 0.00 Aphidicolin 0.00 Oxyacanthine sulfate 0.00 4-Methylumbelliferone 0.00 Wogonin 0.00 Lavendustin B 0.00 Reserpine 0.00 Isoreserpine, (-)- 0.00 Vineomycin A1 0.00 Panaxatriol 0.00 .
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  • Comparative Pharmacokinetic Study of Luteolin After Oral Administration Of

    Comparative Pharmacokinetic Study of Luteolin After Oral Administration Of

    Vol. 8(16), pp. 422-428, 29 April, 2014 DOI 10.5897/AJPP2013.3835 ISSN 1996-0816 African Journal of Pharmacy and Copyright © 2014 Author(s) retain the copyright of this article Pharmacology http://www.academicjournals.org/AJPP Full Length Research Paper Comparative pharmacokinetic study of luteolin after oral administration of Chinese herb compound prescription JiMaiTong in spontaneous hypertensive rats (SHR) and Sprague Dawley (SD) rats Zhao-Huan Lou1, Su-Hong Chen2, Gui-Yuan Lv1*，Bo-Hou Xia1, Mei-Qiu Yan1, Zhi-Ru Zhang1 and Jian-Li Gao1 1Institute of Material Medica, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053, China. 2Academy of Tradition Chinese Medicine, Wenzhou Medical University, Wenzhou 325035, China. Received 7 August, 2013; Accepted 15 April, 2014 JiMaiTong (JMT), a Chinese herb compound prescription consisted of Flos chrysanthemi Indici, Spica prunellae and Semen cassiae for anti-hypertension. Luteolin is one of the major bioactivity compositions in F. chrysanthemi Indici in JMT. There are some reports about pharmacokinetics of luteolin in extract of F. chrysanthemi and husks of peanut in normal rats, but it lacked pharmacokinetic information of luteolin residing in a Chinese herb compound prescription in hypertensive animal models. The present study aimed to develop a high-performance liquid chromatography with photodiode array detection (HPLC-DAD) method for determination of luteolin in rat plasma and for pharmacokinetic study after oral administration of JMT to spontaneous hypertensive rats (SHR) and normal Sprague Dawley (SD) rats. After oral administration of JMT to SHR and SD rats, respectively the content of luteolin in blood samples at different time points were determined by a reversed-phase high- performance liquid chromatography (RP-HPLC) coupled with liquid-liquid phase extraction.
  • Herbal Insomnia Medications That Target Gabaergic Systems: a Review of the Psychopharmacological Evidence

    Herbal Insomnia Medications That Target Gabaergic Systems: a Review of the Psychopharmacological Evidence

    Send Orders for Reprints to [email protected] Current Neuropharmacology, 2014, 12, 000-000 1 Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence Yuan Shia, Jing-Wen Donga, Jiang-He Zhaob, Li-Na Tanga and Jian-Jun Zhanga,* aState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; bDepartment of Pharmacology, School of Marine, Shandong University, Weihai, P.R. China Abstract: Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the -aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects, numerous studies focusing on the neurotransmitter GABA and herbal medicines have been conducted. Traditional herbal medicines, such as Piper methysticum and the seed of Zizyphus jujuba Mill var. spinosa, have been widely reported to improve sleep and other mental disorders. These herbal medicines have been applied for many years in folk medicine, and extracts of these medicines have been used to study their pharmacological actions and mechanisms. Although effective and relatively safe, natural plant products have some side effects, such as hepatotoxicity and skin reactions effects of Piper methysticum. In addition, there are insufficient evidences to certify the safety of most traditional herbal medicine. In this review, we provide an overview of the current state of knowledge regarding a variety of natural plant products that are commonly used to treat insomnia to facilitate future studies.
  • Antidepressant-Like Behavioral and Neurochemical Effects of the Citrus

    Antidepressant-Like Behavioral and Neurochemical Effects of the Citrus

    Available online at www.sciencedirect.com Life Sciences 82 (2008) 741–751 www.elsevier.com/locate/lifescie Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin ⁎ Li-Tao Yi, Jian-Mei Li, Yu-Cheng Li, Ying Pan, Qun Xu, Ling-Dong Kong State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China Received 14 July 2007; accepted 16 January 2008 Abstract Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic–pituitary–adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CMS-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/ 5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects, and might help to elucidate its mechanisms of action that are involved in normalization of stress- induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity.
  • NINDS Custom Collection II

    NINDS Custom Collection II

    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC