DOCSLIB.ORG

Complete List of Compounds Screened with the Primary Screening Assay Against Dengue Virus Infection

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Complete List of Compounds Screened with the Primary Screening Assay Against Dengue Virus Infection SUPPLEMENTARY DATA Table 3: Complete List of Compounds Screened with the Primary Screening Assay against Dengue Virus infection. Percentage of Inhibition of Compounds DENV Infection Lapachone, - 98.84 Mycophenolic acid 92.38 Lycorine HCl 86.86 Ivermectin 84.62 C6 Ceramide 84.06 Anisomycin 82.49 Shikonin 78.94 Cycloheximide 78.71 Chelerythrine Cl 73.36 Skimmianine 61.96 Actinomycin D 59.60 Narasin 55.89 Rapamycin 55.12 Tunicamycin B 55.01 Acivicin 54.32 Cotinine, (-)- 52.71 Cantharidin 51.87 Epigallocatechin gallate 50.92 Gitoxigenin 49.01 Kainic acid 48.87 Brefeldin A 47.12 Dicoumarol 45.99 Diacetoxyscirpenol 45.55 Austricin 45.01 Valinomycin 43.34 Thapsigargin 42.90 Strophanthidin acetate 41.96 Trimethylpsoralen, 4,5',8- 41.86 Echinomycin 41.52 Chromomycin A3 40.87 Tryptanthrin 39.03 Sanguinarine 38.73 Songorine 38.09 Condelphine 37.45 Salinomycin 35.54 Phorbol 12,13-dibutyrate 35.35 Nigericin Na 34.02 Deoxyphorbol 13- phenylacetate 20-acetate, 12- 33.74 Desoxypeganine HCl 33.07 Usnic acid, (+)- 32.59 Quisqualic acid 32.13 Gossypol 31.17 Spectinomycin sulfate 30.71 Embelin 29.70 Phorbol 12-myristate 13- acetate 29.58 Tanshinone IIA 29.01 Methoxyluteolin, 6- 28.76 Veratridine 28.47 Sevedindione 28.18 Bicuculline, (+)- 26.81 Oligomycin A 26.75 Strychnine HCl 26.70 Carminic acid 26.67 Luteolin 25.92 Manool 25.59 Homoorientin 25.09 Radicicol 25.09 Tropine 24.50 3-B-Indoleacrylic acid 24.45 Baccatin III 24.40 Citreoviridin 23.71 Bavachinin A 23.50 Ryanodine 22.87 Vulpinic acid 22.42 Quinidine HCl 22.34 Heliotrine 22.01 Saponarin 21.61 Gambogic acid 21.60 Podocarpic acid 21.36 Digitoxin 21.35 Harringtonine 20.81 Myricetin 20.49 Retinoic acid, 9-cis- 20.14 Rotenone 20.07 Cinobufagin 19.81 Taxol 19.79 Atropine-N-oxide 18.92 Myristicin 18.74 Graveoline 17.97 Menadione 17.05 Quassin 16.98 Castanospermine 16.95 Piceatannol 16.58 Protopine HCl 16.52 Ouabain (-)- 16.41 Honokiol 16.37 Caffeic Acid 16.14 Maritimein 15.82 Cyclopamine 15.72 Bergenin 15.59 CAPE 15.49 Gelsemine HCl 15.40 Wedelolactone 15.28 Isorhoifoline 15.15 Tetrahydroalstonine 14.72 Apigenin 14.68 Fumonisin B2 14.62 Hypocrellin B 13.70 Colchicine 13.27 Berberine HCl 13.17 Datiscetin 13.02 Visnagin 12.65 Tomatidine 12.44 Rottlerin 12.23 Myricitrin 12.21 Diosmetine 12.15 Vinpocetine 11.99 Rubescensin A 11.92 Deacetylcolchicine, N-formyl- 11.59 Andrographolide 11.31 Epibatidine, (±)- 11.28 Oleanolic acid 11.19 Convolvamine HCl 11.14 Wortmannin 11.06 Deguelin 11.00 Ajmaline 10.85 Harmaline HCl 10.60 Dihydroergocristine mesylate 10.50 Chrysoeriol 10.44 Narirutin 10.43 Daunorubicin HCl 10.36 Magnolol 10.34 Emodin 10.16 Lysergol 10.01 Parthenolide 10.01 Monensin Na 9.87 Ingenol 3,20-dibenzoate 9.82 Hydroxyflavone, 7- 9.78 Kavain (+/-) 9.71 Dihydrotanshinone 9.69 Cerulenin 9.54 Australine HCl 9.46 Diosmin 9.25 Grayanotoxin III 9.15 Retinoic acid (all trans) 9.09 Bulleyaconitine A 8.99 Delcorine 8.74 Prostaglandin A1 8.55 Peganole 8.48 Ebelactone B 8.39 Deltaline 8.30 Solasodine 8.25 Deoxyphorbol 13-acetate, 12- 8.02 Tamarixetine 7.95 Yangonin 7.93 Dihydroxy-4'-methoxy- chalcone, 2',6'- 7.80 Genistein 7.74 Isorhamnetine-3-O-glucoside 7.73 Chaetomellic acid A 7.73 Betulinic acid 7.63 Remerine HCl 7.62 Antibiotic A-23187 7.53 Theobromine 7.30 Chrysine 7.29 Eriocitrin 7.21 Bromocriptine mesylate 6.93 Karakoline 6.77 Ginkgolide A 6.74 Naringenin 6.47 Geranylgeranoic acid 6.30 Sinomenine 6.28 Methysticin 5.97 Bromolaudanosine, (±)-6'- 5.90 Cyclopiazonic acid 5.89 Forskolin 5.78 Galanthamine HBr 5.77 Daidzin 5.63 Chelidonine, (+)- 5.57 Troleandomycin 5.50 Asarinin, (-)- 5.37 Lapiferine 5.36 Salsolinol HBr 5.34 Lincomycin 5.24 Oxocafestol, 16- 5.16 Daidzein 5.10 Sinensetine 5.09 Mimosine, L- 5.05 Mithramycin A 5.04 Piperine 5.03 Imperialine 4.80 Conessine 4.77 Isorhamnetine-3-O-rutinoside 4.75 Diacetylkorseveriline 4.69 Marein 4.66 Tubercidin 4.64 Andrographolide, dehydro- 4.61 Pratol 4.50 Euphorbiasteroid 4.48 Dihydroxyflavone, 6,7- 4.37 Ursolic acid 4.36 Apigenin-7-O-glucoside 4.30 Papaverine HCl 4.25 Xanthotoxin 4.19 Didymin 4.16 Boldine 4.13 Puromycin 3.97 Aucubin 3.92 Homatropine HBr 3.88 Neomycin sulfate 3.75 E-64 3.59 Scopolamine N-oxide HBr, (-)- 3.51 Veratramine 3.47 Matrine 3.44 Demethylepipodophyllotoxin, 4'- 3.33 Fisetin 3.33 Isovitexin 3.18 Domoic acid 3.05 Norharmane 2.93 Retinoic acid, 13-cis- 2.76 Sclareol 2.67 Scopolomine N-butylbromide 2.43 Bufalin 2.40 Kaempferol-7- neohesperidoside 2.17 Flavokawain B 2.14 Salsolidine 2.12 Silybine 1.98 Harmalol HCl 1.88 Carnosic acid 1.86 Lapidine 1.69 Formononetin 1.59 Vincristine sulfate 1.24 Decoyinine 1.23 Huperzine A, (-)- 1.23 GERI-BP002-A 0.90 Santonin 0.84 Oxokahweol, 16- 0.81 Glycyrrhetinic acid, 18-- 0.73 Eburnamonine, (-)- 0.61 Kaempferol-3-O-glucoside 0.58 Ginkgolide B 0.56 Kaempferol 0.52 Hydrocotarnine HBr 0.45 Himbacine 0.27 Vincamine 0.12 Amygdalin 0.11 Auraptene 0.08 Tschimganidin 0.00 Dubinidine 0.00 Etoposide 0.00 Myriocin 0.00 Phloretin 0.00 Prostaglandin F2 0.00 Coumermycin A1 0.00 Isoscopoletine 0.00 Atropine sulfate 0.00 Isosakuranetin 0.00 Cycloserine, L- 0.00 Curcumin 0.00 Yohimbine HCl 0.00 Laudanosoline HBr 0.00 Tschimganine 0.00 Homobutein 0.00 Oxytetracycline, -apo- 0.00 Monocrotaline 0.00 Perillic acid 0.00 Dihydromethysticin 0.00 Nitrarine 2HCl 0.00 Ungerine nitrate 0.00 Pinocembrin 0.00 Vitexin-2"-O-rhamnoside 0.00 Fumagillin 0.00 Aconitine 0.00 Isotetrandrine 0.00 Kanamycin 0.00 Methoxyflavone, 5- 0.00 Nicotine, (-)- 0.00 Citrinin 0.00 Rhoifolin 0.00 Kahweol 0.00 Pseudopelletierin HCl 0.00 Picrotoxinin 0.00 Sitosterol, - 0.00 C2 Phytoceramide 0.00 Prostaglandin B1 0.00 E-64-D 0.00 Harmine HCl 0.00 Rosmarinic acid 0.00 Baicalein 0.00 Cevadine 0.00 Kenpaulone 0.00 Gramine 0.00 Ketopinic acid 0.00 Taxifolin (+) 0.00 Sulfuretine 0.00 E-64-C 0.00 Cyclosporin A 0.00 Fillalbin 0.00 Brucine n-oxide 0.00 Catalpol 0.00 Heteratisine 0.00 Resveratrol 0.00 Norfluorocurarine 0.00 Rhamnetine 0.00 Artesunate 0.00 Harmol HCl 0.00 Butein 0.00 Penicillamine, L- 0.00 Robinetine 0.00 Aristolochic acid A 0.00 Genistin 0.00 Nonactin 0.00 Homoeriodictyol (-) 0.00 Morin 0.00 Pilocarpine HCl 0.00 Jervine 0.00 Trichodesmine 0.00 Prostaglandin E2 0.00 Picrotin 0.00 Quercetin 0.00 Luteolin-3',7-di-o-glucoside 0.00 Vinblastine sulfate 0.00 Hyoscyamine 0.00 Capsaicin 0.00 Rauwolscine 0.00 Naringenin-7-O-glucoside 0.00 Hernandezine 0.00 Prostaglandin E1 0.00 Indirubin 0.00 Swainsonine 0.00 Berbamine 2HCl 0.00 Rifampicin 0.00 Bilobalide 0.00 E6 Berbamine 0.00 Phorbol 12,13-dibutyrate, 4-- 0.00 Arecoline HBr 0.00 Feroline 0.00 Cytochalasin B 0.00 Quinine HCl 0.00 Amentoflavone 0.00 Sterigmatocystin 0.00 Eriodictyol 0.00 Eriodictyol-7-O-glucoside 0.00 Phorbol 12-myristate 13- acetate, 4-- 0.00 Phytosphingosine 0.00 Melatonin 0.00 Gingerol 0.00 Cytochalasin D 0.00 Cytochalasin E 0.00 Eudesmine 0.00 Camptothecin 0.00 Doxorubicin HCl 0.00 Mevastatin 0.00 Plumbagin 0.00 Ellipticine 0.00 Prostaglandin J2 0.00 Hydroxycamptothecin, 10- 0.00 Hypericin 0.00 Gliotoxin 0.00 Tetrandrine 0.00 Podophylotoxin 0.00 Rhapontin 0.00 Galangine 0.00 Ecdysone 0.00 Dipterocarpol 0.00 Stachydrine HCl 0.00 Seneciphylline 0.00 Streptonigrin 0.00 Ferulic acid 0.00 Bleomycin 0.00 Ellagic acid 0.00 Methylergonovine 0.00 Naringin 0.00 Sarsasapogenin 0.00 Scopoletin 0.00 Cafestol acetate 0.00 Quercitrin 0.00 Securinine 0.00 Silymarin 0.00 Tetrahydropapaverine 0.00 Aloe-emodine 0.00 Noreleagnine 0.00 Madecassic acid 0.00 Isocorydine HCl 0.00 Abscisic acid, (±)- 0.00 Mitomycin C 0.00 Isoquercitrine 0.00 Leucomisine 0.00 Cephradine 0.00 Khellin 0.00 Betulin 0.00 Gibberellic acid, (+)- 0.00 Vitexin 0.00 Demissidine 0.00 Catharanthine base 0.00 Corydaline 0.00 Schisandrin A, R(+)- 0.00 Capreomycin sulfate 0.00 Carnitine Cl, (±)- 0.00 Chartreusin 0.00 Zearalanol, - 0.00 Limonin 0.00 Lappaconitine 0.00 Dehydrokawain, 5,6- 0.00 Rifamycin SV-NA 0.00 Senecionine 0.00 Nalidixic acid 0.00 Lupinine 0.00 Geraldol 0.00 Chlorogenic acid 0.00 Sclerotiorin 0.00 Anabasine HCl 0.00 Antimycin A1 0.00 Brassinin 0.00 Asiatic acid 0.00 Indole-3-butyric acid 0.00 Lagochiline 0.00 Ferutinin 0.00 Friedelin 0.00 Panaxadiol 0.00 Rutaecarpine 0.00 Geniposide 0.00 Tetrahydrolipstatin 0.00 Pimaricin 0.00 Muscarine Cl, (+)- 0.00 Cotininecarboxylic acid, trans- 4- 0.00 Protoveratrine B 0.00 Cryptotanshinone 0.00 Vindoline 0.00 Griseofulvin, (+)- 0.00 Dehydrocostus Lactone 0.00 Salsoline 0.00 Amphotericin B 0.00 Hordenine sulfate 0.00 Sedanolide 0.00 Noscapine, (±)- 0.00 Physostigmine 0.00 Ecdysone, - 0.00 Phorbol 0.00 Kinetin 0.00 Evodiamine 0.00 Retrorsine 0.00 Flavokawain A 0.00 Bergapten 0.00 Dihydrorobinetin 0.00 Zearalenone 0.00 Flavanomarein 0.00 Artemisinin 0.00 Cinchonidine, (-)- 0.00 Hesperidine 0.00 Anisodamine 0.00 Neohesperidin 0.00 Coumestrol 0.00 Epicatechin, (-)- 0.00 Deoxyshikonin 0.00 Minocycline 0.00 Acacetine 0.00 Sclareolide, (3aR)-(+)- 0.00 Thymoquinone 0.00 Ingenol 0.00 Phlorizine 0.00 Arbutin 0.00 Cytisine, (-)- 0.00 Patulin 0.00 Schisandrin B, S(-)- 0.00 Hesperetine 0.00 Syringetine-3-O-glucoside 0.00 Cepharanthine 0.00 Schisantherin A 0.00 Dihydrolysergol, 9,10- 0.00 Lobeline HCl 0.00 Shikimic Acid 0.00 Indole-3-carbinol 0.00 Spartein sulfate (-)- 0.00 Trigonelline HCl 0.00 Peruvoside 0.00 Lavendustin A 0.00 Osthole 0.00 Ochratoxin A 0.00 Azomycin 0.00 Solanesol 0.00 Vinorelbine base 0.00 Indole-3-acetic acid 0.00 Cafestol 0.00 Caryophyllene oxide 0.00 Palmatine Cl 0.00 Catechin hydrate, (+)- 0.00 Vanillylacetone 0.00 Corynanthine 0.00 Hypocrellin A 0.00 Hirsutine 0.00 Biochanin A 0.00 Isorhamnetine 0.00 Harmane HCl 0.00 Rutin 0.00 Solanine, - 0.00 Diindolylmethane 0.00 Pinocembrin-7-methylether 0.00 Hydrastine, D-- 0.00 Lasalocid A Na 0.00 Hydroxytropinone, 6- 0.00 Cinchonine, (+)- 0.00 D-Tubocurarine-chloride 0.00 Aphidicolin 0.00 Oxyacanthine sulfate 0.00 4-Methylumbelliferone 0.00 Wogonin 0.00 Lavendustin B 0.00 Reserpine 0.00 Isoreserpine, (-)- 0.00 Vineomycin A1 0.00 Panaxatriol 0.00 .
Load more

Recommended publications
  • Effects of Mimosine Administered to a Perfused Area of Skin in Angora Goats by R
    Downloaded from British Journal of Nutrition (1996), 15, 69-19 69 https://www.cambridge.org/core Effects of mimosine administered to a perfused area of skin in Angora goats BY R. PUCHALA, S. G. PIERZYNOWSKI, T. SAHLU* AND S. P. HART E. (Kika) de la Garza Institute for Goat Research, Langston University, Langston, Oklahoma 73050, USA . IP address: (Received I1 November 1994 - Revised 15 March 1995 -Accepted I1 May 1995) 170.106.34.90 The effect of mimosine on a perfused area of skin tissue was studied using an isolated perfusion technique. Four mature Angora wethers (body weight 35 (SE 2.3) kg) were cannulated bilaterally with indwelling silicone catheters in the superficial branches of the deep circumflex iliac artery and vein. Mimosine , on (40 mg/kg metabolic weight (Wo75)per d) was infused intra-arterially into one iliac artery of each goat for 3 d and saline was infused in the contralateral (control) iliac artery. Iliac venous blood samples were 27 Sep 2021 at 22:01:16 taken from both sides along with arterial samples from the carotid artery. Mimosine infusion elevated plasma mimosine in the carotid artery (52.6 (SEM19.21) pol/l) and iliac vein on the saline-treated side to 54.1 (SEM 16-31)~ol/l and in the iliac vein on the mimosine-treated side to 191.3 (SEM1914) pmol/l (P < 0.01). Mimosine decreased feed intake (2.3 v. 0.6 kg/d, ~~~0.29;P < 0.001) and water consumption (5-2 v. 1.3 litres/d, SEM 0.67; P < 0.001).
    [Show full text]
  • Review on the Nutritive Value and Toxic Aspects of Leucaena Leucocephala
    Trop Anim Prod 1979 4:2 113 A REVIEW ON THE NUTRITIVE VALUE AND TOXIC ASPECTS OF LEUCAENA LEUCOCEPHALA U ter Meulen1, S Struck1, E Schulke2 and E A El Harith1 1 Institut fur Tierphysiologie und Tierernahrung der Universitat Gottingen Oskar-Kellner-Weg 6, Weende 3400 Gottingen, West Germany This review discusses the nutritive value of Leucaena leucocephala and its mimosine toxicity when used as a forage for livestock. Chemical analysis and feeding trial. have indicated that Leucaena leaf-meal with its high protein, calcium, -carotene and xanthophyll contents, is potentially a valuable feed for livestock in the tropics. The symptoms of mimosine toxicity in cattle, sheep, poultry, goats horses, pigs and rats ire discussed, The chemical value of mimosine and the possible mechanism of its toxicity are reviewed. Possible solutions to the toxicity problem are presented together with the suggestion that further studies be initiated to overcome this problem. Key Words: Leucaena, mimosine toxicity, livestock, forage, feeding trials The uses of the tropical legume Leucaena leucocephala are quite versatile. These uses include its function as a source of firewood and timber,its role in soil erosion control (Dijkman 1950), its ability to provide shade for other plants as well as its function in maintaining the fertility of the soil and of serving as a nutritious forage for animal feed (Ruskln 1977). Presently the greatest use of this plant in animal nutrition is its incorporation in cattle feed. Leucaena leaf-meal, with its rich protein, minerals and vitamin content, is also becoming a popular ingredient in poultry feeds in the tropics (D'Mello and Taplin 1978).
    [Show full text]
  • Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella Alata (Anura: Bufonidae): Antiprotozoal Activity Against Trypanosoma Cruzi
    molecules Article Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi Candelario Rodriguez 1,2,3 , Roberto Ibáñez 4 , Luis Mojica 5, Michelle Ng 6, Carmenza Spadafora 6 , Armando A. Durant-Archibold 1,3,* and Marcelino Gutiérrez 1,* 1 Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Apartado 0843-01103, Panama; [email protected] 2 Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India 3 Departamento de Bioquímica, Facultad de Ciencias Naturales, Exactas y Tecnología, Universidad de Panamá, Apartado 0824-03366, Panama 4 Smithsonian Tropical Research Institute (STRI), Balboa, Ancon P.O. Box 0843-03092, Panama; [email protected] 5 Centro Nacional de Metrología de Panamá (CENAMEP AIP), Apartado 0843-01353, Panama; [email protected] 6 Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Apartado 0843-01103, Panama; [email protected] (M.N.); [email protected] (C.S.) * Correspondence: [email protected] (A.A.D.-A.); [email protected] (M.G.) Abstract: Toads in the family Bufonidae contain bufadienolides in their venom, which are charac- Citation: Rodriguez, C.; Ibáñez, R.; terized by their chemical diversity and high pharmacological potential. American trypanosomiasis Mojica, L.; Ng, M.; Spadafora, C.; is a neglected disease that affects an estimated 8 million people in tropical and subtropical coun- Durant-Archibold, A.A.; Gutiérrez, M. tries. In this research, we investigated the chemical composition and antitrypanosomal activity Bufadienolides from the Skin of toad venom from Rhinella alata collected in Panama.
    [Show full text]
  • Preventive and Therapeutic Effects of Chinese Herbal Compounds Against Hepatocellular Carcinoma
    molecules Review Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma Bing Hu 1,*, Hong-Mei An 2, Shuang-Shuang Wang 1, Jin-Jun Chen 3 and Ling Xu 1 1 Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; [email protected] (S.-S.W.); [email protected] (L.X.) 2 Department of Science & Technology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 202032, China; [email protected] 3 Department of Plastic & Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, The Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China; [email protected] * Correspondence: [email protected]; Tel.: +86-21-64385700 Academic Editor: Derek J. McPhee Received: 16 November 2015 ; Accepted: 20 January 2016 ; Published: 27 January 2016 Abstract: Traditional Chinese Medicines, unique biomedical and pharmaceutical resources, have been widely used for hepatocellular carcinoma (HCC) prevention and treatment. Accumulated Chinese herb-derived compounds with significant anti-cancer effects against HCC have been identified. Chinese herbal compounds are effective in preventing carcinogenesis, inhibiting cell proliferation, arresting cell cycle, inducing apoptosis, autophagy, cell senescence and anoikis, inhibiting epithelial-mesenchymal transition, metastasis and angiogenesis, regulating immune function, reversing drug
    [Show full text]
  • New Markers in the Mycotox Profile
    New Markers in the MycoTOX Profile We are happy to announce the addition of four new mycotoxin markers to our MycoTOX Profile. The test now includes 11 mycotoxins from 40 species of mold, making it by far the most comprehensive and competitively priced mycotoxin test available. It also still more sensitive and accurate than other tests available, because we use LC/MS/MS technology. Here is an overview of the four new mycotoxin markers: Gliotoxin Gliotoxin (GTX) is produced by the mold genus Aspergillus. Aspergillus spreads in the environment by releasing conidia which are capable of infiltrating the small alveolar airways of individuals. In order to evade the body’s defenses Aspergillus releases Gliotoxin to inhibit the immune system. One of the targets of Gliotoxin is PtdIns (3,4,5) P3. This results in the downregulation of phagocytic immune defense, which can lead to the exacerbation of polymicrobial infections. Gliotoxin impairs the activation of T-cells and induces apoptosis in monocytes and in monocyte-derived dendritic cells. These impairments can lead to multiple neurological syndromes. Mycophenolic Acid Mycophenolic Acid (MPA) produced by the Penicillium fungus. MPA is an immunosuppressant which inhibits the proliferation of B and T lymphocytes. MPA exposure can increase the risk of opportunistic infections such as Clostridia and Candida. MPA is associated with miscarriage and congenital malformations when the woman is exposed in pregnancy. Dihydrocitrinone Dihydrocitrinone is a metabolite of Citrinin (CTN), which is a mycotoxin that is produced by the mold species Aspergillus, Penicillium, and Monascus. CTN exposure can lead to nephropathy, because of its ability to increase permeability of mitochondrial membranes in the kidneys.
    [Show full text]
  • Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation
    pharmaceutics Article Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation Li Wang 1,2, Weiwei Wu 1,2, Lingling Wang 1,2, Lu Wang 1,2 and Xiuhua Zhao 1,2,* 1 College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China; [email protected] (L.W.); [email protected] (W.W.); [email protected] (L.W.); [email protected] (L.W.) 2 Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China * Correspondence: [email protected]; Tel.: +86-451-82191517; Fax: +86-451-82102082 Received: 18 September 2019; Accepted: 24 October 2019; Published: 1 November 2019 Abstract: Honokiol (HK), a well-tolerated natural product, has many multiple pharmacological activities. However, its poor water solubility and low bioavailability limit its clinical application and development. The aim of this research was to prepare the solid dispersion (SD) formulation of honokiol (HK) with poloxamer-188 (PLX) as the carrier, thereby improving its solubility and oral bioavailability. Firstly, by investigating the relationship between the addition amount of the PLX and the solubility of HK, and the effects of solid dispersions with different ratios of HK–PLX on the solubility of HK, we determined that the optimum ratio of PLX to HK was (1:4). Then, the HK–PLX (1:4) SD of HK was prepared using the solvent evaporation method. The morphology of the obtained HK–PLX (1:4) SD was different from that of free HK. The HK in the HK–PLX (1:4) SD existed in amorphous form and formed intermolecular hydrogen bonds with PLX.
    [Show full text]
  • Fungal Keratitis: Immune Recognition, Neutrophil-Hyphae Interactions, And
    FUNGAL KERATITIS: IMMUNE RECOGNITION, NEUTROPHIL-HYPHAE INTERACTIONS, AND FUNGAL ANTI-OXIDATIVE DEFENSES by SIXTO MANUEL LEAL JR. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Thesis Advisor: Eric Pearlman, Ph.D. Department of Pathology CASE WESTERN RESERVE UNIVERSITY August, 2012 CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the dissertation of ______________________________________________________ candidate for the Ph.D. degree *. (signed)_______________________________________________ (chair of the committee) ________________________________________________ ________________________________________________ ________________________________________________ ________________________________________________ ________________________________________________ (date) _______________________ *We also certify that written approval has been obtained for any proprietary material contained therein. Dedication I dedicate this cumulative work to the invisible hand that has blessed my personal and academic life with incredible people, guidance, talent, courage, perseverance, and productivity. 3 Table of Contents List of Figures 7 List of Tables 9 Acknowledgements 10 List of Abbreviations 12 Abstract 14 Chapter 1. Introduction Fungi in their natural environment 16 Fungi and human disease 18 Fungi that cause human corneal infection 21 Fungal keratitis- Clinical characteristics and outcome 22 Anti-microbial Defenses at the Ocular Surface 23 Immune Recognition of Fungi 27 β2 integrins
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2006/014 1075A1 Talbott (43) Pub
    US 2006O141075A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/014 1075A1 Talbott (43) Pub. Date: Jun. 29, 2006 (54) METHODS AND COMPOSITIONS FOR Publication Classification WEIGHT MANAGEMENT AND MOOD ENHANCEMENT (51) Int. Cl. A6IR 36/82 (2006.01) A6IR 36/752 (2006.01) (76) Inventor: Shawn M. Talbott, Draper, UT (US) A6II 3/522 (2006.01) A6II 3/56 (2006.01) Correspondence Address: A6IR 33/26 (2006.01) MACPHERSON KWOK CHEN & HEID LLP A 6LX 36/575 (2006.01) 1762 TECHNOLOGY DRIVE, SUITE 226 (52) U.S. Cl. ......................... 424/729; 424/736: 424/774; SAN JOSE, CA 95110 (US) 424/769; 514/263.31; 514/171; 424/646 (21) Appl. No.: 11/360,312 (57) ABSTRACT The present invention provides nutritional Supplement com (22) Filed: Feb. 23, 2006 positions and processes for treatment using nutritional Supplements that assist in weight management. One aspect Related U.S. Application Data of the invention comprises the inclusion in a single Supple ment constituent(s) that assist in reduction of a subjects (62) Division of application No. 10/895.253, filed on Jul. cortisol level, thermogenic constituent(s), and constituent(s) 20, 2004. that assist in stabilizing blood Sugar levels. Patent Application Publication Jun. 29, 2006 Sheet 1 of 4 US 2006/01.41075A1 Global Mood State (Profile of Mood States) 160 -8.6% 150 140 130 120 o Mood, Pre 110 Effect of a stress/cortisol-controlling dietary supplement on Global Mood States following 12 weeks of supplementation. P = placebo. S = Supplement. * = P <0.05 compared to Pre.
    [Show full text]
  • Comparative Pharmacokinetic Study of Luteolin After Oral Administration Of
    Vol. 8(16), pp. 422-428, 29 April, 2014 DOI 10.5897/AJPP2013.3835 ISSN 1996-0816 African Journal of Pharmacy and Copyright © 2014 Author(s) retain the copyright of this article Pharmacology http://www.academicjournals.org/AJPP Full Length Research Paper Comparative pharmacokinetic study of luteolin after oral administration of Chinese herb compound prescription JiMaiTong in spontaneous hypertensive rats (SHR) and Sprague Dawley (SD) rats Zhao-Huan Lou1, Su-Hong Chen2, Gui-Yuan Lv1*，Bo-Hou Xia1, Mei-Qiu Yan1, Zhi-Ru Zhang1 and Jian-Li Gao1 1Institute of Material Medica, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053, China. 2Academy of Tradition Chinese Medicine, Wenzhou Medical University, Wenzhou 325035, China. Received 7 August, 2013; Accepted 15 April, 2014 JiMaiTong (JMT), a Chinese herb compound prescription consisted of Flos chrysanthemi Indici, Spica prunellae and Semen cassiae for anti-hypertension. Luteolin is one of the major bioactivity compositions in F. chrysanthemi Indici in JMT. There are some reports about pharmacokinetics of luteolin in extract of F. chrysanthemi and husks of peanut in normal rats, but it lacked pharmacokinetic information of luteolin residing in a Chinese herb compound prescription in hypertensive animal models. The present study aimed to develop a high-performance liquid chromatography with photodiode array detection (HPLC-DAD) method for determination of luteolin in rat plasma and for pharmacokinetic study after oral administration of JMT to spontaneous hypertensive rats (SHR) and normal Sprague Dawley (SD) rats. After oral administration of JMT to SHR and SD rats, respectively the content of luteolin in blood samples at different time points were determined by a reversed-phase high- performance liquid chromatography (RP-HPLC) coupled with liquid-liquid phase extraction.
    [Show full text]
  • Herbal Insomnia Medications That Target Gabaergic Systems: a Review of the Psychopharmacological Evidence
    Send Orders for Reprints to [email protected] Current Neuropharmacology, 2014, 12, 000-000 1 Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence Yuan Shia, Jing-Wen Donga, Jiang-He Zhaob, Li-Na Tanga and Jian-Jun Zhanga,* aState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; bDepartment of Pharmacology, School of Marine, Shandong University, Weihai, P.R. China Abstract: Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the -aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects, numerous studies focusing on the neurotransmitter GABA and herbal medicines have been conducted. Traditional herbal medicines, such as Piper methysticum and the seed of Zizyphus jujuba Mill var. spinosa, have been widely reported to improve sleep and other mental disorders. These herbal medicines have been applied for many years in folk medicine, and extracts of these medicines have been used to study their pharmacological actions and mechanisms. Although effective and relatively safe, natural plant products have some side effects, such as hepatotoxicity and skin reactions effects of Piper methysticum. In addition, there are insufficient evidences to certify the safety of most traditional herbal medicine. In this review, we provide an overview of the current state of knowledge regarding a variety of natural plant products that are commonly used to treat insomnia to facilitate future studies.
    [Show full text]
  • Antidepressant-Like Behavioral and Neurochemical Effects of the Citrus
    Available online at www.sciencedirect.com Life Sciences 82 (2008) 741–751 www.elsevier.com/locate/lifescie Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin ⁎ Li-Tao Yi, Jian-Mei Li, Yu-Cheng Li, Ying Pan, Qun Xu, Ling-Dong Kong State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China Received 14 July 2007; accepted 16 January 2008 Abstract Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic–pituitary–adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CMS-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/ 5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects, and might help to elucidate its mechanisms of action that are involved in normalization of stress- induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity.
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]