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UMass Center for Clinical and Translational Science Seminars 2013 UMCCTS Seminars

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Nanoparticles in Biomedicine: Delivery and Sensing

Vincent Rotello University of Massachusetts - Amherst

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Repository Citation Rotello V. (2013). Nanoparticles in Biomedicine: Delivery and Sensing. UMass Center for Clinical and Translational Science Seminars. https://doi.org/10.13028/zdj9-vk19. Retrieved from https://escholarship.umassmed.edu/umccts_seminars/2013/seminars/1

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I) Nanoparticle therapeutics a) Supramolecular triggering b) Immunomodulation

II) Delivery a) Nanoparticle capsules b) Protein delivery

II) Sensing a) Proteins b) Cell surfaces c) Tissues

2 nm core diameter Au particles -stable in biofluids (inc serum) Duncan, B.; Kim, C.; Rotello, V. M. J. Control. Release, 2010, 148, 122-127. -redispersible Kim, C.-K.; Agasti, S. S.; Zhu, Z.J.; Isaacs, L.; Rotello, V.M. Nature Chem., 2010, 2, 962-966.

Moyano, D. F.; Goldsmith, M.; Solfiell, D. J.; Landesman-Milo, D.; Miranda, O. R.; Peer D.*; Rotello, V. M.* J. Am. Chem. Soc., in press Patra, D.; Sanyal, A.; Rotello, V. M. Chem.-Asian J., 2010, 5, 2442-2453.

Yang, X.-C.; Samanta, B.; Agasti, S. S,; Jeong, Y.; Zhu, Z.-J.; Rana, S.; Miranda, O.R.; Rotello, V. M.” Angew. Chem., 2011 50, 477-481 .

can we use this strategy for cell surface sensing? the key is tuning the interface Au nanoparticles bound to analytes don’t look much different than unbound

De. M.; Rana, S.; Akpinar, H.; Miranda, O.R.; Arvizo, R. R.; Bunz, U. H. F.; Rotello, V. M. Nature Chem. 2009, 1, 461-465.

Bajaj, A.; Miranda, O. R.; Kim, I.-K.; Phillips, R. L.; Jerry, D. J.; Bunz, U. H. F.; Rotello, V. M. Proc. Nat. Acad. Sci., 2009, 106, 10912-10916.

The “out of time” summary:

Gold nanoparticles provide:

Potential therapeutics -triggered cytotoxicity -tunable immunomodulation

Building blocks for nanocapsules -for drug and protein delivery -direct to the cytosol!

Effective “chemical nose” sensors for: -cancer cells (healthy, cancerous, metastatic) -metastases (induced—the real thing!) Acknowledgments: Collaborators Current: postdoc Craig Martin Alumni: postdocs Sung-Tae Kim Mike Knapp Vikas Nandwana Gilles Clavier Tyler Norsten Richard Vachet Allan Goodman Roy Shenhar Chang Soo Kim Paul Lahti Alam Syed Belma Erdogan Serdar Burmaoglu Ulf Drechsler “Pops” Arumugam Yoni Englen “Thai” Thayumanavan Todd Emrick (PSE) C-C You Amitav Sanyal Current: grads Amitav Sanyal Yuval Ofir Tom Russell (PSE) Yu Xi Mark Tuominen (Phys) Chandra Subramani Joe Jerry (Vet.An.Sci) Alumni: grad students Subinoy Rana Bing Nie Basar Gider Dave Solfiel Sallie Smith (Vet.Ani.Sci) Eric Breinlinger Ayush Verma Brian Creran Neil Forbes (Chem. E) Michael Greaves Hiroshi Nakade Xiaoning Li Maria Santore (PSE) Angelika Niemz Hao Xu Youngdo Jeong Jim Watkins (PSE) Robert Deans Gang Han Yi-Cheun Yeh Uwe Bunz (H-Burg) Alex Cuello Sud Srivastava Bo Yan Jean Chmielewski(Purdue) Trent Galow Brian Jordan Krishendu Saha Bogdan Dragnea (IU) Faysal Ilhan Rochelle Arvizo Daniel Moyano Graeme Cooke (Glasgow) Eunhee Jeoung Mrinmoy De Brad Duncan M.B. Holl (Michigan) Mark Gray Bappa Samanta Ying Jiang Lyle Isaacs (Maryland) Andy Boal Partha Ghosh Robul Mout Dan Peer (Tel Aviv) Kanad Das Oscar Miranda Gulen Yesilbag Funding Kate Goodman Apiwat Champoosor Ryan Landis NIH,NSF, ONR, DOE Joe Simard Myoung-Hwan Park Ngoc Le Ray Thibault Jiang Xu Moumita Ray NSF CHM-NSEC Joe Carroll Chaekyu Kim Yuqing Xing NSF MRSEC, Army Oktay Uzun Keck Foundation Nick Fischer BAE, Teijin, Firmenich Ben Frankamp Rui Hong