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Scientific Documentation VI140, Vitamin E Acetate, USP Not appropriate for regulatory submission. Please visit www.spectrumchemical.com or contact Tech Services for the most up‐to‐date information contained in this information package. Spectrum Chemical Mfg Corp 769 Jersey Avenue New Brunswick, NJ 08901 Phone 732.214.1300 Ver4.01 20.April.2016 Dear Customer, Thank you for your interest in Spectrum’s quality products and services. Spectrum has been proudly serving our scientific community for over 45 years. It is our mission to manufacture and distribute fine chemicals and laboratory products with Quality and delivery you can count on every time. To accomplish our mission, Spectrum utilizes our sourcing leverage and supplier qualification expertise in offering one of the industry’s most comprehensive line of fine chemical products under one brand, in packaging configurations designed to meet your research and production requirements. Our product grades include: USP, NF, BP, EP, JP, FCC, ACS, KSA, Reagent grade, as well as DEA controlled substances. We operate facilities in the United States on the East Coast, West Coast, as well as in Shanghai, China in order to provide the best logistical support for our customers. At Spectrum, Quality is priority number one. Suppliers with the best qualifications are preferred and we employ full-functioning in-house analytical laboratories at each of our facilities. Our facilities and systems are USFDA registered and ISO certified. We frequently host customer audits and cherish opportunities for improvements. Quality is engrained into our culture. Quality is priority number one. In the following pages, we have designed and prepared documented scientific information to aid you in your initial qualification or your continual use of our products. Please do not hesitate to contact us if further information or the most up-to-date documentation is desired from any of the covered areas. We appreciate your business and we look forward to hearing from you. Sincerely, Alan Wang, MSQA, ASQ CQA Senior Manager, Global Supplier Quality Assurance [email protected] 20.Apr.2016 VI140, Vitamin E Acetate, USP Table of Contents Product Specification Safety Data Sheet (SDS) Manufacturer Manufacturing Process Flowchart Certification of Quality Mangement System (QMS) Certification of current Good Manufacturing Practices (cGMP) Product BSE/TSE Statement Product Allergen Statement Product Aflatoxin Statement General Label Information – Sample Label Product Certificate of Analysis Sample(s) General Lot Numbering System Guidance Stability – Shelf Life Guidance Kosher Certificate 20.Apr.2016 Specification for Vitamin E Acetate, USP (VI140) Item Number VI140 Item Vitamin E Acetate, USP CAS Number 7695-91-2 Molecular Formula C31H52O3 Molecular Weight 472.75 MDL Number Synonyms DL-α-Tocoferil Acetate ; (+/-)-α-Tocopherol Acetate ; DL-a-Tocopheryl Acetate Test Specification Min Max ASSAY (C31H52O3) 96.0 - 102.0 % ACIDITY TO PASS TEST IDENTIFICATION TO PASS TEST CERTIFIED KOSHER EXPIRATION DATE MANUFACTURE DATE RESIDUAL SOLVENTS TO PASS TEST SAFETY DATA SHEET Preparation Date: 01/16/2015 Revision Date: 1/16/2015 Revision Number: G1 Product identifier Product code: VI140 Product Name: VITAMIN E ACETATE, USP Other means of identification Synonyms: DL-alpha-Tocopherol Acetate DL-alphaa-Tocopheryl acetate; dl-Vitamin E acetate; All-rac-alpha-Tocopheryl acetate; Tocopherol Acetate; (+/-)-alpha-Tocopherol acetate; alpha-Tocopherol acetate; alpha-Tocopheryl acetate; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate CAS #: 7695-91-2 RTECS # GA8747000 CI#: Not available Recommended use of the chemical and restrictions on use Recommended use: No information available. Uses advised against No information available Supplier: Spectrum Chemicals and Laboratory Products, Inc. 14422 South San Pedro St. Gardena, CA 90248 (310) 516-8000 Order Online At: https://www.spectrumchemical.com Emergency telephone number Chemtrec 1-800-424-9300 Contact Person: Martin LaBenz (West Coast) Contact Person: Ibad Tirmiz (East Coast) 2. HAZARDS IDENTIFICATION Classification This chemical is not considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Not a dangerous substance or mixture according to the Globally Harmonized System (GHS) Label elements Product code: VI140 Product name: VITAMIN E ACETATE, 1 / 11 USP Not classified Hazards not otherwise classified (HNOC) Not Applicable Other hazards Not available 3. COMPOSITION/INFORMATION ON INGREDIENTS Components CAS-No. Weight % Trade Secret Vitamin E Acetate 7695-91-2 100 * 7695-91-2 4. FIRST AID MEASURES First aid measures General Advice: Poison information centres in each State capital city can provide additional assistance for scheduled poisons (13 1126) Skin Contact: Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes. Get medical attention if irritation develops. Consult a physician if necessary. Eye Contact: Flush eye with water for 15 minutes. Get medical attention if irritation occurs. If symptoms persist, call a physician. Inhalation: Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion: Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Consult a physician if necessary. Most important symptoms and effects, both acute and delayed Symptoms Health injuries are not known or expected under normal use. Indication of any immediate medical attention and special treatment needed Notes to Physician: Treat symptomatically Protection of first-aiders First-Aid Providers: Avoid exposure to blood or body fluids. Wear gloves and other necessary protective clothing. Dispose of contaminated clothing and equipment as bio-hazardous waste 5. FIRE-FIGHTING MEASURES Extinguishing Media Suitable Extinguishing Media: Carbon dioxide (CO2). Dry chemical. Water spray. Alcohol- resistant foam. Unsuitable Extinguishing Media: Do not use a solid (straight) water stream as it may scatter and spread fire. Product code: VI140 Product name: VITAMIN E ACETATE, 2 / 11 USP Specific hazards arising from the chemical Hazardous Combustion Products: Carbon oxides Specific hazards: May be combustible at high temperatures. May be ignited by heat, sparks or flames. Container explosion may occur under fire conditions or when heated. Special Protective Actions for Firefighters Specific Methods: Water mist may be used to cool closed containers. For larger fires, use water spray or fog. Cool containers with flooding quantities of water until well after fire is out. Dike fire-control water for later disposal; do not scatter the material. Special Protective Equipment for Firefighters: As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Personal Precautions: Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Use personal protective equipment. Remove all sources of ignition. Environmental precautions Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Methods and material for containment and cleaning up Methods for containment Stop leak if you can do it without risk. Absorb spill with inert material (e.g. vermiculite, dry sand or earth). In case of large spill, dike if needed. Dike far ahead of liquid spill for later disposal. Methods for cleaning up Use appropriate tools to put the spilled material in a suitable chemical waste disposal container. Clean contaminated surface thoroughly. 7. HANDLING AND STORAGE Precautions for safe handling Technical Measures/Precautions: Provide sufficient air exchange and/or exhaust in work rooms. Remove all sources of ignition. Keep away from incompatible materials. Safe Handling Advice: Wear personal protective equipment. Use only in well-ventilated areas. Avoid contact with skin, eyes and clothing. Keep away from heat and sources of ignition. Do not breathe vapors or spray mist. Do not ingest. When using do not smoke. Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Technical Measures/Storage Conditions: Protect from light. Sensitive to light. Store in light-resistant containers. Store under nitrogen. Keep container tightly closed in a dry and well-ventilated place. Store at room temperature in the original container. Store away from incompatible materials. Product code: VI140 Product name: VITAMIN E ACETATE, 3 / 11 USP Incompatible Materials: Acids. Alkalis. Bases. Oxidizing agents. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters National occupational exposure limits United States Components OSHA NIOSH ACGIH AIHA WHEEL None None None None Vitamin E Acetate - 7695-91-2 Canada Components Alberta British Columbia Ontario Quebec None None None None Vitamin E Acetate - 7695-91-2 Australia and Mexico Components Australia Mexico Vitamin E Acetate None None 7695-91-2 Appropriate engineering controls Engineering measures to reduce exposure: Ensure adequate ventilation. Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors and mist below their respective threshold limit value. Individual protection measures, such as personal protective equipment
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