Queensland Brain Institute Annual Report 2019 Vice-Chancellor’s message

Front cover: Astrocytes, the most common neural cell type, grown on a dish. These cells were used to study glioblastoma, the most common malignant brain cancer in adults. By Zorana Lynton, Richards group, People's Choice Winner, 2019 Art in Neuroscience competition.

Above: Jacaranda blooms in UQ's Great Court. The Queensland Brain Institute (QBI) is a world-leading neuroscience research institute, located on our St Lucia campus. It is dedicated to unravelling the secrets of our brain, an immensely complex structure at the core of every activity we undertake as humans.

QBI research has the potential to not only within the Medical Research Future translational research, it is important to unlock fundamental knowledge about who Fund to create a business case for the acknowledge that translation requires a we are and how our brain works, but also establishment of a new industry sector in foundation of knowledge from which to to stem the growing tide of brain diseases therapeutic ultrasound. The work is being draw. In recognition of the importance of that have such a devastating social and done in collaboration with partners from discovery research aimed at generating economic impact on our world. across Australia and New Zealand and was new knowledge, and to provide funding the only project in Queensland to receive certainty, QBI has established a Discovery 2019 saw some important steps forward in Research Endowment Fund. this mission. Stage One funding from the MRFF Frontier Health and Medical Research scheme. This fund, which will be officially One of the most exciting projects at launched in 2020, is an ambitious, QBI research has also provided the basis QBI, and one which elicits great interest long-term undertaking that recognises for a trial into the effect of exercise on from around the world, is the ultrasound the importance of pursuing avenues of technology from the laboratory of cognitive function in ageing adults. enquiry without immediate gain. The Professor Jürgen Götz, Director of QBI’s The trial aims to establish the level vision is to provide QBI researchers with Clem Jones Centre for Ageing Dementia and intensity of exercise that improves the intellectual freedom to investigate the Research. Professor Götz and his team are cognitive function, and also to investigate brain and tackle projects where the benefit working on an ultrasound device that could the underlying mechanisms that enable may not be immediately apparent during more effectively deliver therapeutics to exercise to positively affect the brain. This the course of the standard grant cycle. the brain for the treatment of Alzheimer’s research, which is generously supported QBI is one of the forces behind UQ’s disease. The team has spent the past 12 by the Stafford Fox Foundation, has been continued position in the world’s top months working towards a first-in-human proceeding in partnership with UQ's 100 universities, providing high-quality trial of their device. School of Human Movement and Nutrition neuroscience research, driven through local Science. It is hoped that a full analysis of In addition to the potential for this and global collaborations with researchers, the data gathered will be available in 2020. technology to improve our healthcare industry, government and philanthropists. We are grateful to all of the members of and quality of life, the development our community who helped drive this Congratulations to Professor Sah and the of an effective device to treat brain research by participating in the trial. QBI team on their commitment and their diseases would also seed opportunities excellent results. I look forward to watching in the medical device industry and create The trials outlined above are excellent QBI continue to create positive change in jobs within manufacturing and with illustrations of projects that began through the years to come. service providers. In recognition of this curiosity-driven, fundamental research, technology’s potential, the Australian and are now being translated to improve Professor Peter Høj AC Government awarded $1 million in funding lives through better health. As competitive Vice-Chancellor and President from a fiercely competitive scheme funding continues to emphasise The University of Queensland

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 1 Chairman’s Message

2019 has been an outstanding year for Professor Annemaree Carroll for taking the Foundation, whose continued generous QBI, with significant accomplishments time to provide us with an insight into their support has helped QBI to continue its across many areas. very interesting and ever-evolving work. important work. The past year was marked by the Thanks also to Professor Pankaj Sah for his QBI’s success in its field is a testament to introduction of QBI’s Discovery Research continued leadership of the Institute and the efforts of the entire team of scientists Endowment Fund which will focus on the reappointment as Director for the next five and support staff, whose passion and future sustainability of QBI. The greatest years. His guidance through this year’s UQ tireless commitment to the science that barrier to QBI’s future success is financial: 7-Year Review process also resulted in very underpins our success, helps ensure that without sustainable funding, the Institute positive results for the Institute, which is an we continue to be a world leader in the will find it increasingly difficult to retain outstanding achievement. area of neuroscience research. The progress high, performing staff and support critical of QBI’s dementia research, is just one Some highlights of the year included: research areas. The Endowment Fund has example of how QBI is leading the way been established and will continue to build • The establishment of the Human Brain through cutting-edge research. Professor over the coming years helping to support Studies Unit which will facilitate more Jürgen Götz and his team within QBI’s all scientists in the Institute who are efficient translation of science to clinical Clem Jones Centre for Ageing Dementia concentrating on curiosity-driven research practice, and provide QBI with an Research are currently working towards in the hope of making the next big scientific accessible public face through its human the first stage of a clinical safety trial for discovery. research activities. their non-invasive ultrasound technology • Successful fundraising events including in tackling Alzheimer’s disease, while In yet another busy year for the Institute, the Hand Heart Pocket Alzheimer’s Emeritus Professor Perry Bartlett, Founding I would like to extend a personal thank Gala and the Ross Maclean Race Day, Director of QBI, is leading the development you to my fellow board members for their which helped contribute to continued of a clinical trial for a potential treatment commitment and ongoing support of QBI. philanthropic growth. for motor neurone disease. The advice and guidance provided from the Board’s perspective has helped raise • A high level of grant success. The urgent need to find strategies to awareness of the work of QBI to a broader I am also grateful to all at QBI: our prevent, diagnose and treat dementia, and audience. A special thank you also goes researchers, and our support and technical many other brain-related diseases, is the to Provost, Professor Aidan Byrne and staff, for their passion and tireless focus of QBI’s researchers who are working Pro-Vice Chancellor, Professor Tim Dunne, commitment to the science that underpins hard towards achieving this goal. Based for their attendance at our Board meetings, our success, plus the Advancement team on our history of achievement and current which helps provide a better understanding for their wonderful support to QBI in all initiatives at QBI, and with strong ongoing of how the University functions and QBI’s areas. support from UQ and our external partners role in this process. and donors, we will capitalise on our many The Board would like to express its deep successes and face challenges as they arise. The addition of one of QBI’s researchers gratitude to the Government, foundations, I am looking forward to supporting QBI in presenting at each meeting has enabled corporates, industry partners and countless the exciting times ahead. the Board to gain a greater understanding individuals for generously supporting of the many and varied research activities QBI’s work over the past year. I would which take place at the Institute. I would like to especially mention the Clem Jones Jeff Maclean like to thank Professor Linda Richards, Foundation, Brazil Family Foundation Chairman Dr Steven Zuryn, Dr Susannah Tye and and the Stafford Fox Medical Research QBI Advisory Board

2 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Director’s Message

Looking back on 2019, I’m proud to say in Australia, keeping up the momentum to We also built on our existing global we’ve gone from strength to strength, continue our life-changing work advancing partnerships, with exciting advances in our continuing to grow our reputation as treatments for Alzheimer’s disease and collaboration with the Southern University an institution of excellent neuroscience brain diseases more generally. of Science and Technology (SUSTech) in research that is delivering real impact in Shenzhen, China. Together with researchers Our grant success was complemented by understanding the brain. from UQ’s Faculty of Engineering, philanthropic funding from our generous Architecture and IT, we progressed a joint There’s no doubt that this is the result of the donors. This supports research that may SUSTech-UQ neural bioengineering Masters outstanding accomplishments made across not be funded through other national program, where students will be able to so many areas of QBI by the talented schemes, and accelerates discoveries for complete three years of an undergraduate researchers, teams and partnerships the benefit of the community. To secure degree in engineering at SUSTech, before behind them. this support into the future, we established undertaking a further two years at UQ. It is a Discovery Research Endowment Fund, We underwent our second 7-year UQ hoped that many of these students will then which will launch officially in 2020. This Academic Board review, an important choose to enrol in a PhD program. is an ambitious, long-term project that chance to not only reflect on all we have will provide stability and certainty for our I would like to thank UQ’s Vice-Chancellor achieved in the past seven years, but also research programs, and allow us to back Professor Peter Høj and Provost Professor present our vision for the future. The Review exciting blue-sky research. Aidan Byrne for their unwavering support Committee was impressed with the high of the Institute, as well as Advisory Board quality of our research, our enviable track Congratulations to Professor John McGrath Chair Mr Jeff Maclean and our other record in grant funding, and the standards on receiving the Lieber Prize for Outstanding Board members for their astute guidance of our technical and support staff. Achievement in Schizophrenia Research, throughout the year. awarded by the New York-based Brain & The Committee also offered some sound Behavior Research Foundation. We were Thank you to my Deputy Directors: recommendations that we have started to also pleased that Professor Linda Richards Professor Linda Richards (Research), implement, and will continue rolling out in was acknowledged for her commitment to Ms Stephanie Jillett and Ms Jill Penridge 2020. These include organising our research neurobiology research and to community (Operating – Stephanie to June, and Jill into a number of themes, developing a engagement in science, being named an from June to year-end) for their assistance clinical trial unit to progress our research Officer in the Order of Australia. and dedication towards the day-to-day to the clinic, and encouraging all members management of the Institute. of our diverse workforce to achieve their Professors Joe Lynch and Mandyam best by establishing an Equity, Diversity and Srinivasan retired following very successful Lastly, I’m extremely indebted to all at Inclusion committee, and supporting our careers. I was delighted that the Vice- QBI, for their passion, their commitment early- and mid-career researchers towards Chancellor conferred them both with the to our research vision, and their ongoing independence. well-deserved title of Emeritus Professor. contributions to our success. Our researchers continued to secure We also learned of the sad passing of I am looking forward to an even greater competitive grants at rates above national Emeritus Professor Jack Pettigrew in May. 2020. averages, including $1 million from the We held a celebratory retrospective in Professor Pankaj Sah Medical Research Future Fund’s Frontier October showcasing his life in science, Director Health and Medical Research scheme to including his time as Director of the UQ develop the therapeutic ultrasound industry Vision, Touch and Hearing Research Centre.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 3 Research themes

Our research is divided into four themes that collectively encompass neuroscience discovery from the level of individual cells to entire organisms to the clinic.

Synaptic, Cellular and Circuits, Systems and Molecular Neuroscience Computational Neuroscience

Our researchers investigate how our brain operates at the level of We explore how groups of cells, often in different parts of the individual cells, encompassing both the inner workings of cells and brain, interact with each other. This includes studying which way their interactions with one another. The brain is unique because the information travels and how groups of cells control the flow its cells communicate with each other, a process that can adapt of information. Our computational neuroscience researchers take and change depending on an individual’s experience – the source the complexities of the brain and simplify them into mathematical of the brain’s amazing plasticity. Drug therapies also operate at models, based on available experimental data, that give us this scale, so by understanding the workings of the brain at the hypotheses about how the brain might function. These hypotheses cellular and molecular level, we are much more likely to find targets can then be tested by experimental neuroscientists, whose findings for conditions such as Alzheimer’s disease, schizophrenia, motor further inform the computational models in a cycle that delivers neurone disease and more. us ever-more detailed information and predictions about brain function. This level of neuroscience is the most likely to provide Faculty: us with knowledge about how the brain actually works: how Professor Fred Meunier (Theme Co-ordinator) information is transferred to ensure the right parts of the brain are active to achieve tasks, and other parts of the brain do not interfere. Professor Helen Cooper It is also the level about which we know the least, making our Professor Elizabeth Coulson efforts in this area key to understanding the brain. Professor Geoffrey Faulkner Faculty: Professor Jürgen Götz Professor Stephen Williams Professor Tianzi Jiang (Theme Co-ordinator) Professor Massimo Hilliard Dr Zhaoyu Li Dr Victor Anggono Dr Zhitao Hu Dr Fatima Nasrallah Associate Professor Dr Jana Vukovic Dr Patricio Opazo Kai-Hsiang Chuang Dr Adam Walker Professor Linda Richards Professor Geoff Goodhill Dr Steven Zuryn Professor Pankaj Sah Dr Dhanisha Jhaveri

4 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Cognitive, Behavioural and Genomics and Sensory Neuroscience Clinical Neuroscience

Research in our theme focuses on sensory processing, brain Our genomics researchers explore brain function by functions and resulting behaviours that affect the whole of an investigating the genome and how our DNA influences individual. This includes tracking inputs to the brain through our behaviour, brain structure and function and our multiple sensory systems and brain outputs in the form of predisposition to neurological and mental health disorders cognition and behaviour. If we want to understand the brain such as schizophrenia and motor neurone disease. Our clinical and ourselves, we need to understand how sensory inputs researchers work directly with patients to improve prevention shape the responses of humans, and a variety of model animal strategies, diagnoses and treatments. They are on the front systems, to the environment and to the specific needs of each line of developing new treatments and diagnostics to improve species. In the case of humans, we may think of this how brain quality of life for affected people and their families. activity drives cognition and behaviour, including capacities Faculty: such as attention, learning, memory and decision making. Professor Peter Nestor (Theme Co-ordinator) Faculty: Emeritus Professor Perry Bartlett Professor Jason Mattingley (Theme Co-ordinator) Associate Professor Terry Coyne Associate Professor Timothy Bredy Professor John McGrath Associate Professor Thomas Burne Professor Bryan Mowry Professor Barry Dickson Professor Peter Silburn Professor Darryl Eyles Professor Naomi Wray Professor Justin Marshall Associate Professor Margie Wright Associate Professor Gail Robinson Emeritus Professor Mandyam Srinivasan Dr Susannah Tye Associate Professor Bruno van Swinderen

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 5 Research highlights

Life expectancy mapped for people Extinguishing fear memories relies 18-year study uncovers new clue with mental disorders on an unusual change to DNA to treating schizophrenia People with mental disorders have a life Researchers led by Associate Professor Tim A joint Australian-Indian study published expectancy up to a decade shorter than the Bredy and Dr Xiang Li discovered a DNA in JAMA Psychiatry has identified a new general population, a research team co-led modification that enhances our ability to clue about the causes of schizophrenia by Professor John McGrath found. The extinguish fear, a finding that could help and possible development of potential study, which was published in The Lancet, guide the development of new treatments treatments. A collaboration between QBI found that mental disorders shortened life for fear-related anxiety disorders. In a researchers, including Professor Bryan expectancy by an average of 10 years for study published in Nature Neuroscience, Mowry, and a team of Indian researchers led men and seven years for women. the researchers found that fear extinction by Professor Rangaswamy Thara, co-founder memories form thanks to a modification, to and director of the Schizophrenia Research Deep-sea fish use colour to see the DNA base adenosine, that increases the Foundation in Chennai, searched the in the dark activity of certain genes. genomes of more than 3000 individuals and found those with schizophrenia were more An international team of researchers, likely to have a particular genetic variation. including Professor Justin Marshall and How an Alzheimer’s disease protein Dr Fabio Cortesi, discovered that certain impairs brain cells species of deep sea fish may have highly Scientists have shed more light on the way Blood cells the missing link in sensitive colour vision. In particular, they a key toxic protein in Alzheimer’s disease post-exercise boost have shown that the visual system of the damages brain cells. Research from the An international team including Dr Tara silver spinyfin Diretmus( argenteus) has the laboratories of Professor Jürgen Götz and Walker and Dr Odette Leiter discovered a highest number of light-sensitive proteins, Dr Steven Zuryn, published in The EMBO new way in which exercise boosts the brain. called opsins, of any vertebrate known to Journal, found that the protein tau impairs The team investigated the blood to see what date, even though it lives at depths where the ability of neurons to recycle and remove changes occur after exercise, and found that most sunlight has been filtered out. The waste of the cell’s energy-maker: the platelets cause neural stem cells to multiply research was published in Science. mitrochondrion. and develop into new neurons. The study was published in Stem Cell Reports.

The silver spinyfin has the highest number of light-sensitive proteins of any known vertebrate, despite living in the dark.

6 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Above: Platelets cause neural stem cells (pictured) to multiply and develop into new neurons following exercise.

Above right: The signalling protein Fyn moving and forming clusters in living brain neurons – viewed using super-resolution microscopy.

Right: By studying brain neuronal and immune cells, a potential drug target for Alzheimer’s disease has been discovered.

Microscopic worms could provide key to repairing injured nerves Researchers including Professor Massimo Hilliard, Dr Rosina Giordano-Santini and Dr Casey Linton discovered key information on how the microscopic roundworm species C. nets, which provide a supportive mesh elegans spontaneously reconnects severed Dementia clue found by tracking around certain neurons and stabilise the nerves. They discovered the protein RAB-5 single molecules in living brain cells contacts these cells make with other controls the level of the molecule that Super-resolution single molecule neurons. The research may explain why begins the process of fusing separated microscopy has allowed researchers led by vitamin D is so important to brain plasticity axons, a finding published in theJournal of Professors Frédéric Meunier and Jürgen and how vitamin D deficiency leads to a Neuroscience. Götz to give insight into the organisation of range of cognitive disorders, including key proteins in living brain cells. The finding depression and schizophrenia. Stopping enzyme could launch that the protein Tau, involved in Alzheimer’s disease, affects the organisation of the two-pronged attack on Alzheimer’s New model offers hope for disease signalling protein Fyn, which plays a key role in memory formation, is a step towards schizophrenia treatments Targeting an enzyme that affects both discovering the cause of the most common Professor Darryl Eyles led a team that the immune and nervous systems could type of dementia. It was published in eLife. developed a new animal model of combat Alzheimer’s disease on two fronts, schizophrenia that will enable researchers Dr Ramón Martínez-Mármol and Professor around the world to better understand Frédéric A. Meunier found in a study Researchers net new theory on the disease and develop new treatments. published in the Journal of Neuroscience. vitamin D and cognitive disorders The model, described in a paper in Nature The enzyme dPI3K produces a toxic Associate Professor Thomas Burne and Schizophrenia, elevates dopamine in a peptide which accumulates into plaques team published two papers in Brain region of the brain called the dorsal striatum. in the brain of Alzheimer’s patients. The Structure and Function and Trends research found the enzyme is also involved in Neuroscience that show vitamin D in the secretion of an important signalling levels influence the integrity of a type of protein involved in inflammation. ‘scaffolding’ in the brain called perineuronal

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 7 Grants and Fellowships

Alzheimer’s Association (USA) T Bredy – Defining novel neuroepigenetic Children’s Hospital Foundation Alzheimer’s Association Research pathways that influence learning and Children’s Hospital Foundation Research Fellowship grant memory, 10/01/2019 – 09/01/2022, Program $430,000. J Camats Perna – Impact of Tau B Wainwright, B Day, S Trost, N Bradford, aggregation on the anti-inflammatory J Götz – Regulation of mRNA translation J Bunt & G de Zubicaray et al – Virtual properties of IL37 in AD, 01/01/2019 – by the microtubule-associated protein Tau, centre for child and adolescent brain cancer 31/12/2019, $2,000. 01/01/2019 – 31/12/2021, $464,000. research (awarded to and administered by UQ’s Institute for Molecular Bioscience), F Meunier – Unveiling the nanoscale 01/01/2019 – 30/06/2021, $3,500,000. Atmosphere and Ocean Research organisation and dynamics of synaptic Institute vesicle pools, 01/01/2019 – 31/12/2021, Interdisciplinary Collaborative Research $668,000. Ecological Society of Australia Program Future Fellowship Holsworth Endowment Round 1 Y Iwata, W S Chung, N Sato – Evolution J Yang - Deciphering the genetic H Middleton – Behavioural evidence of of courtship behaviour in squid (awarded architecture of human complex traits pheromone use by an elasmobranch, to and administered by the University of (awarded to and administered by UQ’s 20/07/20 19 – 20/07/2020, $6,375. Tokyo), 01/09/2019 – 01/09/2020, $35,000. Institute for Molecular Bioscience), 01/07/2019 - 30/06/2023, $918,125. Engineering and Physical Sciences Australian Academy of Science Research Council (EPSRC) France and Europe Early- and Mid-Career EPSRC International Centre-to-Centre Researcher (EMCR) Mobility Grants Australian Research Data Commons Research Collaborations Program ARDC Discovery Activities Institutional A Philippides, T Nowotny, P Graham, X Cui – PET imaging in a novel animal Role in a Data Commons J Marshall, M Mangan, E Vasilaki, model of schizophrenia: enhanced N Durisic & R Amor – Australian B Van Swinderen, A Barron & K Nordstrom dopamine in prodromal, 29/09/2019 – Neuroscience Microscopy Data Sharing – ActiveAI – active learning and selective 30/06/2020, $5,000. Platform, 5/15/2019 – 9/02/2019, $49,999. attention for robust, transparent and efficient AI (awarded to and administered Australian Government Cooperative Brain Foundation by University of Sussex), 01/07/2019 – Research Centres (CRC) program Research Gift Grants 30/06/2022, $917,753. Autism CRC Innovation Project Grant R San Gil & A Walker – Genome-wide CRISPR L Richards, G Robinson, C Franklin & screens to reveal regulators of TDP-43 German Research Foundation D Trembath – The detection of white aggregation and toxicity in motor neurone DFG Fellowship matter microstructural alterations in disease and frontotemporal dementia, I Kirmes - Unravelling a small non-coding autistic individuals at clinical magnetic field 01/11/2019 – 31/10/2020, $25,000. RNA interface between the mitochondrial strengths, 01/07/2019 – 31/12/2019, $17,680. and nuclear genomes (In German), Brisbane Diamantina Health 01/04/2019 - 31/03/2021 (Administered by Australian Research Council Partners DFG host university). Discovery Early Career Researcher Awards Brain and Mental Health Theme W Harrison - Memory of natural visual Translational Research Partnerships Great Barrier Reef Foundation environments, 09/07/2019 - 08/07/2022, Seed Funding Reef Trust Partnership – Community Reef $385,288. J Kesby & S Suetani – The impact of Protection Grant Program – Stage 1: associative striatal dysfunction on M Joensuu - A novel role for saturated fatty Citizen Science decision-making and cognitive flexibility acids in memory and learning, 08/07/2019 - CoralWatch – Educating communities to in treatment-refractory schizophrenia, 07/07/2022, $422,107. help ACT and PROTECT our Great Barrier 01/01/2019 – 01/01/2020, $9,000. Reef, 31/05/2019 – 31/05/2021, $99,200. X Li - Functional role of a novel DNA modification in the adult brain, 01/01/2019 - Cancer Council Australia Illawarra Health and Medical 31/12/2021, $374,433. Project Grant Research Institute Discovery Project Grants S Kisely, S Jordan, D Lawrence, G Sara, Justin Yerbury Travel Scholarships B Kendall, L Brophy, D Siskind & M Protani V Anggono, A Keramidas & B Collins – R San Gil – Travel award, 01/01/2019 – – What is the impact of the national bowel Regulation of glutamate receptor dynamics 31/12/2019, $2,500. in mammalian central neurons, 21/05/2019 cancer screening program on colorectal – 20/05/2022, $508,397. cancer outcomes for people over the age of 50 with severe mental illness? (awarded to and administered by UQ’s School of Medicine), 01/06/2019 – 31/05/2022, $651,026.

8 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Mater Misericordiae Ltd National Foundation for Medical P Opazo & D Choquet – The role of Project Grant Research and Innovation calcium/calmodulin-dependent protein kinase II in Alzheimer’s disease, 01/01/2019 National Foundation for Medical Research J Vukovic & I Winkler – Helping damaged – 31/12/2021, $684,920. brains recover (awarded to and and Innovation grant administered by UQ’s School of R Chung, A Walker, L Ittner, A Lee & S Naismith, M O’Sullivan, C Klijn, R Al- Biomedical Sciences), 27/06/2019 – S Rayner – Pre-clinical evaluation of novel Shahi Salman, X Wang, M Barnett, C Carce 27/10/2021, $45,100. therapies for clearance of TDP-43 in & Z Zhou – Triple therapy prevention of amyotrophic lateral sclerosis (awarded to Recurrent Intracerebral Disease EveNts Trial Medical Research Future Fund and administered by Macquarie University), (TRIDENT) – Cognitive sub-study (awarded 01/01/2019 – 30/06/2020, $183,488. to and administered by Sydney Medical MRFF Accelerated Research – Clem Jones School, University of Sydney), 01/01/2019 – Centre for Ageing Dementia Research National Health and Medical 31/12/2023, $1,416,383. J Götz & P Sah – Breaking through dementia – The Clem Jones Centre for Research Council L Richards, G Goodhill & R Suárez – Ageing Dementia Research, 01/04/2019 – Project Grants Role of spontaneous activity in the 31/04/2023, $10,000,000. T Bredy – Toward a deeper understanding formation of functional cortical circuits in of new DNA modifications in fear-related vivo, 01/01/2019 – 31/12/2021, $528,990. MRFF Frontier Health and Medical learning, 01/01/2019 – 31/12/2022, $666,876. Research Program P Sah, D Jhaveri – Unravelling J Götz, E Wolvetang, A Whittaker, A White, E Coulson & K-H Chuang – Mechanisms amygdala-hippocampus neural circuitry K Iyer, N Smith, P Harris, J Gamble, and consequences of cholinergic neuron of anxiety: Role of adult-born neurons, T McSweeney, P Thomas, K McMahon, degeneration in sleep apnea (awarded to 01/01/2019 – 31/12/2022, $874,384. R Steck, & C Brown – Therapeutic and administered by UQ’s School of J Scott, S Blum, B Lennox, J Greer, ultrasound for the treatment of brain Biomedical Sciences), 01/01/2019 – B O’Donoghue, M Benros, D Siskind & disorders, 07/01/2019 – 30/06/2020, 31/12/2021, $932,284. S Suetani – Identifying and treating $1,000,000. J Götz & J Polanco – Unravelling how patients with psychosis who are positive to exosomes induce and propagate tau anti-neuronal antibodies (awarded to and Motor Neurone Disease Research pathology, 01/01/2019 – 31/12/2021, administered by UQ’s Centre for Clinical Institute of Australia $827,521. Research, Faculty of Medicine), 01/01/2019 Betty Laidlaw MND RIA Research grant – 31/12/2021, $810,745. R Harvey & A Keramidas – Investigating M Morsch, A Walker, A Lee & R Chung – NMDA receptor-mediated pathological S Tye – Circuit, cellular and synaptic Targeting the nucleo-cytoplasmic transport mechanisms underlying epilepsy and mechanisms of nucleus accumbens deep machinery in sporadic and familial ALS associated neurological disorders (awarded brain stimulation, 01/01/2019 – 31/12/2022, (awarded to and administered by to and administered by the University $642,948. Macquarie University), 01/01/2019 – of the Sunshine Coast), 01/01/2019 – 31/12/2019, $250,000. B van Swinderen – Bridging the gap 31/12/2021, $592,755. between electrical and molecular sleep MND RIA Jenny and Graham Lang M Hilliard – Understanding the role of the functions in the brain, 01/01/2019 – Collaboration Travel Grant metalloprotease ADM-4/ADAM17/TACE 31/12/2021, $435,792. B Berning – Golgi dysfunction is an early in promoting axonal repair, 01/01/2019 – B van Swinderen – Presynaptic control event associated with TDP-43 pathology 31/12/2021, $676,653. formation in ALS, 04/12/2019 – 06/12/2019, of general anaesthesia, 01/01/2019 – $1,500. M Hilliard – Understanding the role of 31/12/2022, $786,568. UNC-71 in axonal regeneration, 01/01/2019 S Zuryn – Molecular protection against – 31/12/2021, $676,653. Motor Neurone Disease Victoria mitochondrial DNA damage, 01/01/2019 – MND (Victoria) – The Nina Buscombe J Mattingley, E Arabzadeh & M Tang – How 31/12/2021, $525,157. Award do visual predictions affect neural coding? Research Fellowship H Brown-Wright – 2019 Nina Buscombe From whole brain systems to single F Meunier - Senior Research Fellow Award, 12/04/2019 – 12/06/2019, $1,600. neurons, 01/01/2019 – 31/12/2021, $709,254. B - Nanoscale imaging of presynaptic R San Gill – 2019 Nina Buscombe Award, B Mowry & J Giacomotto – Investigating proteins in health and disease, 01/01/2019 - 12/04/2019 – 12/06/2019, $1,600. the neuro-developmental role of 31/12/2023, $717,275. schizophrenia-associated genes using J Venturato – 2019 Nina Buscombe Award, the zebrafish, 01/01/2019 – 31/12/2021, 12/04/2019 – 12/06/2019, $1,600. $481,890.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 9 Pacific Coral Reef Institute & US Dept. of Defence Office of the P Meehan, L Wang, B Laycock, K Steel, OPT ECO Congressionally Directed Medical H Shewan, G Zhao, L Li & D Harrich – Research Programs (CDMRP) Advanced nanoparticle, colloid and Early Career Researcher Grant microparticle characterisation and precision Amyotrophic Lateral Sclerosis Research engineering nanosystems facility L Fogg – Illuminating the impact of light Program (ALSRP) Therapeutic (awarded to and administered by pollution on the visual development of Development Award reef fish in French Polynesia, 01/09/2019 – UQ’s School of Chemical Engineering), 30/09/2020, $7,600. M Wilson, A Walker & A Laird – Rapid flow 01/01/2019 – 31/12/2019, $243,939. cytometry screen for identifying novel ALS drug leads (awarded to and P Burn, P Young, B Schulz, M Walker, Port of Brisbane Pty Ltd administered by The University of M Schembri, J Fraser, C Williams, E Gillam, Community Grant Program Wollongong), 01/01/2019 – 31/12/2020, G Schenk, J De Voss, J Rothnagel, M Fortes, J Marshall, K Hofman & D Kleine $763,452. M Monteiro, V Ferro, U Kappler, I Toth, J Clegg, (CoralWatch) – Moreton Bay corals at your R Hall, K Cheney, T Woodruff, A Tabor, doorstep- Education package, 01/07/2019 – Walter and Eliza Hall Institute P Ebert, R Clark, S Mahler, C Beveridge, 30/06/2020, $15,000. B Gilbert, D Batstone & A Nouwens – 2019 Walter and Eliza Hall Travelling A versatile accurate mass, high resolution Scholarship QTOF mass spectrometer for chemistry and Queensland State Government V O’Callaghan – Genetic and proteomic applications (awarded to and Advance Queensland Women’s Research environmental influences associated with administered by UQ’s School of Chemistry Assistance Program (WRAP) sleep and depression in adolescent twins, and Molecular Biosciences), 01/01/2019 – R Giordano Santini – 25/11/2019 – 11/01/2019 – 31/12/2020, $2,627. 31/12/2019, $320,317. 25/05/2020, $19,500. E Coulson, S Walters, M Piper, O Rawashdeh, The University of Queensland J Widagdo – 05/10/2019 – 06/04/2020, M Reichelt, L Kaminskas, K Borges, G Gobe, $19,393. UQ Genomic Innovation Hub T Woodruff, M Ruitenberg, D Simmons, R San Gil & A Walker – Genome-wide J Cuffe, T Svensen, D Ng, M Smith, J Zhao – 16/09/2019 – 26/04/2020, CRISPR screening for modifiers of M Bellingham, C Stephan, J Cooper-White, $19,500. diverse cellular phenotypes, 01/07/2019 – B Rolfe, K Schroder, A Van Der Ent, 30/06/2020, $51,842. E Assadi Soumeh, F Davis, M Short, Department of Environment and B Degnan & A Walker – Advanced Science: 2019 National Science Week- E Wolvetang, J Mar & S Ngo – Automated Brightfield and Fluorescent High Speed and Regional STEM Program single cell quantitative in situ gene Throughput Slide Scanner for biological, CoralWatch – Virtual Reality (VR) expression in cells and tissues medical, materials science, and agricultural Experience Training, 01/07/2019 – (AutoMerFISH) (awarded to and applications (awarded to and administered 06/09/2019, $2,832. administered by UQ’s Australian Institute by UQ’s School of Biomedical Sciences), for Bioengineering and Nanotechnology), 01/01/2019 – 31/12/2019, $274,725. Advance Queensland: Citizen Science 01/01/2020 – 31/12/2020, $50,000. Grant Round 1 2019 Research Facilities Infrastructure grant CoralWatch – Get Involved – Colours of the Major Equipment and Infrastructure grants (RFIG) (MEI) Reef, 01/08/2019 – 31/08/2021, $29,022. D Abramson, B Lovell, E Scott, I McCulloch, P Sah, L Richards, J Götz, H Cooper, X Zhou & J Carroll – Expanding Wiener, a National Science Week grant G Goodhill, F Meunier, A Yap, D Eyles, high-performance GPU cluster (awarded to CoralWatch – Coral Reefs – Immerse, Learn A Rowan & G Xu – Histology and Advanced and administered by UQ’s Research and Act, 8/10/2019 – 8/18/2019, $17,037. Microscopy Research Facility upgrade, Computing Centre), 01/01/2019 – 01/01/2019 – 31/12/2019, $250,000. 31/12/2019, $590,000. Rebecca L. Cooper Medical K Barlow, R Boyd, L Cocchi, C Middeldorp, D Reutens, N Kurniawan, A Rowan, Research Foundation J Mattingley, H Heussler, M Meinzer & K Thurecht, K-H Chuang, F Nasrallah, Research Grants G Wallace – KidSTIM: A non-invasive E Coulson, & C Chen – Dissolution DNP J Giacomotto – Unveiling the pathogenic neuromodulation laboratory to Hyperpolariser (awarded to and role of the schizophrenia and autism simultaneously improve insight and administered by UQ’s Centre for risk-gene NRXN1 in synaptogenesis, treatment of brain disorders for children in Advanced Imaging), 01/01/2019 – 04/01/2019 – 31/03/2021, $100,000. Queensland (awarded to and administered 31/12/2019, $220,000. by UQ’s Child Health Research Centre), 01/01/2019 – 31/12/2019, $240,700. R Wepf, B Hamilton, I Brereton, K Thurecht, UQ Heron Island Research Station E Undheim, M Mobli, D Craik, G King, Scholarships J Stokes, G Xu, M Gidley, A Nguyen, S Wu, A Jones, M Garson, K Cheney, R Fry, & H Middleton – Behavioural evidence of L Wang, A Whittaker, H Cooper, L Ye, F Meunier – Imaging mass spectrometry pheromone use by an elasmobranch, D Batstone, H Smyth, H Huang, at higher mass resolution (awarded to and 26/06/2019 – 25/06/2020, $2,000. M Heitzmann, S Mahler, C Yu, N Mitter, administered by UQ’s Faculty of Science), K Thurecht, B Carroll, Y Sultanbawa, 01/01/2019 – 31/12/2019, $529,896. T Mahony, P Jensen, M Dargusch, P Mills,

10 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Amplify Women’s Academic Research S Tye – Common mechanisms of anti- Equity (AWARE) Program suicidal drug action, 01/01/2019 – G Bodea – UQ AWARE (awarded to QBI but 31/12/2019, $32,000. transferred to UQ-MRI in 2019) 14/01/2019 – Promoting Women Fellowship 12/07/2019, $50,000. X Cui – Promoting Women Fellowship 2019 F de Busserolles – UQ AWARE, 25/01/2019 Round, 01/01/2019 – 31/12/2019, $12,500. – 14/01/2020, $50,000. UQ-NHMRC Equipment Grant J Widagdo – UQ AWARE, 10/4/2019 – L Richards, P Sah, F Meunier & R Amor 4/3/2020, $50,000. – Advanced microscopy facility camera upgrades, 01/01/2019 – 31/12/2019, $79,181. Early Career Researcher Grants Z Li – Molecular mechanisms of temporal motor control, 01/01/2019 – 31/12/2019, $35,000.

Awards

Queensland Brain Institute Australasian Community for 2019 NARSAD Maltz prize Advanced Organic Semiconductors J Kesby - 08/06/2019 - 31/12/2019, QBI Travel Award for Best Postdoctoral $20,000. Publication (AUCAOS) A Ahier - First Prize (2018), Oral Prize for an outstanding oral 01/01/2019 - 31/12/2020, $1,000. presentation of organic semiconductor Life Sciences Queensland research Rose-Anne Kelso Commemorative Award F Cortesi - First Prize (2019), M Kielar - Ultra-low light detection through S Ngo - (awarded to and administered by 01/01/2020- 31/12/2020, $1,000. changes in open-circuit voltage in organic UQ’s Australian Institute for photodiodes, 01/01/2019 – 31/12/2019, $200 Bioengineering and Nanotechnology) Australian Institute of Policy (gift voucher). 01/01/2019 - 31/12/2019, $3,000. and Science (AIPS) Young Tall Poppy Science Awards Commonwealth of Australia The Cajal Club L Fenlon - 2019 AIPS Young Tall Poppy Order of Australia Medal 2019 Krieg Cortical Kudos Explorer Award Science Award, 13/09/2019 - 12/09/2021, L Richards - 2019 Order of Australia R Suárez - 20/10/2019 – 19/10/2020, $10,000. recipient $3,000. J Kesby - 2019 AIPS Young Tall Poppy Science Award, 02/08/2019 - 31/12/2019, Falling Walls Lab Australasian Chronobiology Society $10,000. 2019 Falling Walls Lab Queensland 2019 Australasian Chronobiology Society S Bandhavkar - Breaking the Wall of Research Excellence Award Australian Academy of Health Depression, 12/04/2019 - 30/09/2019. V O’Callaghan - 15/10/2019 – 14/10/2020. and Medical Sciences 2019 Falling Walls Lab Australia 2019 Australian Academy of Health and The University of Queensland A Zhou - Breaking the wall of age-related Medical Sciences Fellow UQ Award for Excellence in Higher Degree memory deficits, 03/09/2019 - 08/11/2019. P Sah - Fellow of the Australian Academy by Research Supervision of Health and Medical Sciences. National Alliance for Research on T Burne - 01/01/2019 - 01/01/2019, $5,000. Schizophrenia and Depression Australasian Neuroscience Society 2019 NARSAD Lieber prize - 11/01/2019 - 31/12/2020, Mark Rowe Award J McGrath $37,500. X Li - Prize for best publication of the year, 01/01/2019 – 31/12/2019, $1,000

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 11 Our Communities

Our internal 2019 award winners. (L-R): Harrison Evans and Sean Keating (back). Cheryl Filippich, Heather Smith, Rachel Gormal (front).

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 12 Early-Career Researchers

We are home to a thriving community of early-career researchers, whose passion and energy is advancing our neuroscience research and unravelling the mysteries of the brain.

Top left: Drs James Kesby and Laura Fenlon received Tall Poppy Awards. Bottom left: Dr Rodrigo Suárez won the Cortical Explorer Award. Right: Dr Rebecca San Gil was awarded a $300,000 grant from FightMND.

Some of the 2019 highlights from our ECR York-based Brain & Behavior Research contributions to the understanding of the community are: Foundation for work focused on development and evolution of the cerebral understanding the relationship between cortex. The award was presented during Dr Fabio Cortesi was co-first author on a cognitive problems and psychotic the Society for Neuroscience meeting in Science paper that revealed that certain symptoms in people with schizophrenia. Chicago. species of deep sea fish may have highly sensitive colour vision. The paper found Dr Kesby and Dr Laura Fenlon received Our ECRs were also successful in winning that the silver spinyfin possessing the Queensland Young Tall Poppy Awards for independent competitive funding to highest number of light-sensitive proteins, demonstrating excellence in both research progress their research and drive the called opsins, of any vertebrate known to and science communication. Dr Kesby is generation of fundamental knowledge date, despite living at depths where most focusing on ways to improve the long-term and the advancement of new therapies sunlight has been filtered out. The paper, outcomes for people with schizophrenia for neurological disorders. Dr Rebecca which made the journal cover, also involved by studying decision-making skills, while San Gil received a $300,000 grant from QBI ECR Dr Fanny de Busserolles. Dr Fenlon investigates connections in the FightMND to study how nerve cells die in brain, which has implications for conditions motor neurone disease. Dr Laura Fenlon Our ECRs received local, national and such as autism and schizophrenia and also was awarded an Emerging Leadership international awards in recognition of for improving brain function and recovering Fellowship worth more than $500,000 to their world-class research. Dr James from disease. investigate the capacity of the brain for Kesby was presented with the US$20,000 neuroplasticity during different stages of Maltz Prize for Innnovative and Promising Dr Rodrigo Suárez received the Krieg brain development. Schizophrenia Research from the New Cortical Explorer award for his outstanding

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 13 QBI Students

In 2019, QBI had 100 Higher Degree by Ravi Kiran Kasula PhD Clare Harris MPhil Research students enrolled, including 95 Principal advisor: Professor Frederic Meunier Principal advisor: Dr Marta Garrido PhD students, one Master of Philosophy Dynamic re-organisation of Munc18-1 and Modelling the brain as it models (MPhil) candidate and four MPhil in syntaxin-1A nanodomains on the plasma environmental statistics under Neuroscience candidates. membrane of neurosecretory cells during different levels of volatility, threat and exocytosis attention: Using Bayesian Model Selection Eight QBI students were conferred their PhDs, on neuroimaging data to examine and three students were awarded their MPhil. Martin Luehrmann PhD regularity learning under different levels of Principal advisor: Professor Justin Marshall Alessandra Donato PhD volatility, threat and attention Colour vision diversity in coral reef fishes: Principal advisor: Professor Massimo Hilliard Cardinalfish (Apogonidae) Chai Chee Ng MPhil Neuronal response to reactive oxygen Principal advisor: Dr Steven Zuryn species and axonal compartmentalization Jessica Jean McFadyen PhD Discovery of molecules that suppress the in C. elegans neurons Principal advisor: Dr Marta Garrido effect of mitochondrial genome damage. Shortcuts for fear in hierarchical visual Lee Fletcher PhD systems Principal advisor: Professor Stephen Williams Dendritic integration in principal neurons Xiaoqing Zhou PhD of the primary visual cortex Principal advisor: Professor Perry Bartlett The structural and functional changes Andrea Giorni PhD observed in the aged murine hippocampus Principal advisor: Professor Pankaj Sah are ameliorated by physical exercise in a Neurophysiological insights from micro- neurogenesis-dependent manner electrode recordings in DBS patients Drew Cylinder MPhil Se Eun Jang PhD Principal advisor: Associate Professor Principal advisor: Dr Victor Anggono Bruno van Swinderen Characterisation and roles of the The effects of the general anaesthetic postsynaptic Ca2+ sensor Copine-6 in propofol on Drosophila larvae primary neurons

Graduate Profile: Alessandra Donato Years of hard work have led Dr Alessandra Donato to the cusp of a discovery that could result in new treatments for neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. After moving to Australia from Italy in 2013, she completed her PhD in Neuroscience in the Hilliard laboratory at the Queensland Brain Institute in March, 2019. Dr Donato studied oxidative stress in neurons in the roundworm Caenorhabditis elegans. Dr Donato undertook vital experiments on how to stop the neurons from dying – a hallmark of neurodegenerative diseases. “The molecule I identified in my PhD as protecting against oxidative stress in roundworm neurons is now being tested in mammals." Dr Donato has relished her time at UQ, describing the Queensland Brain Institute as a place of excellence, and said she was excited to continue her work here. “What I am trying to achieve is really so much bigger than me – we are trying to find something that will help people and will improve our understanding of the biological process of oxidative stress in neurons and the consequent neurodegeneration.”

14 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Scholarship Winner

Sachithrani Umanda Madugalle from Associate Professor Timothy Bredy’s lab was one of only 17 students nationwide to receive a 2019 Westpac Future Leader Scholarship, awarded to exceptional thinkers with ambition, drive and a generosity of spirit. “We’re interested in neuroplasticity – how the brain learns from experience – in particular, fear learning,” Ms Madugalle said. “When you have a fearful experience, the brain learns to associate that experience with an environmental cue. To abolish that fear, the brain must be repeatedly exposed to that cue without any negative consequences.” “Underlying this process is a whole suite of genetic responses known as epigenetics, which is when changes in gene expression occur in response to the environment, or any mechanism other than changes to the underlying genetic sequence. “My project involves developing innovative techniques that do not exist anywhere in the world to enable us to study how fear learning occurs in the brain at the level of our genes.” It’s important fundamental research that will not only provide insights into how our brain functions, but could also form the basis of treatments for fear-related disorders. “In the future, if we can identify which types of genes and how they’re changing in response to the environment, maybe we can therapeutically manipulate them as well to provide a therapy for PTSD or phobias,” said, Ms Madugalle, who is the third student from the Bredy lab in three years to win one of the prestigious scholarships.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 15 Funding and income

Philanthropy ($4.9M)^ Australian Competitive Grants ($24.5M)# Other Revenue ($10.7M)*

Total Income $57.5M

UQ ($8.9M)^

Other Grants ($8.5M)# Government, industry and not-for-profit organisations

# Amount allocated for 2019 ^ Amount received in 2019 * Includes: Commonwealth Research Block Grant; commercial services, fees & charges; and other operating income

16 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Impact of Philanthropy

In 2019, with the incredible support fundamental research, which is at the core and a vital means of cultivating the next of QBI’s long-term partners, of allowing our researchers to discover what generation of scientists and innovators. happens in both the healthy and diseased UQ, Government, philanthropic QBI brings together smart minds in a smart brain, to achieve translational outcomes. foundations and, most importantly, environment to explore areas that may our valued individual donors, we This year, the establishment of QBI’s lead to medical breakthroughs, including Discovery Research Endowment Fund, was combating some of humanity’s biggest have been able to continue to an important achievement, which will help health issues. Through the continued grow and progress our important ensure the future sustainability of QBI and support of our donors, in the long term, research programs. support all scientists who are concentrating QBI researchers may produce outcomes on curiosity-driven research. This funding that could one day change the world. Your QBI raised a total of $6.81M from 668 gives them the freedom to focus on support helps us maximise our impact for donors in 2019. We pride ourselves on uncovering entirely new possibilities which the future. may potentially unearth major discoveries. working hard to meet the expectations Thank you to our valued donors for your of our generous donors, ensuring their We cannot thank our many donors and support in 2019. We would especially like to experience is meaningful. community advocates enough, who continue acknowledge the generous and continued All gifts, whether large or small, are to support QBI and give so generously support of the Clem Jones Foundation, The important. Philanthropic donations are each year. Your donations and support, in Brazil Family Foundation and the Stafford crucial in supporting QBI’s early-stage, raising awareness of QBI, is indispensable, Fox Medical Research Foundation.

(L-R): Andrea Markey, Director of Advancement; Jeff Maclean, Chairman, Advisory Board; Dr Rebecca San Gil, researcher.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 17 How your donations helped

NFIA Trekkers do the hard yards for QBI

Through the hard work of Brian Davies, a The idea for the walk came while the The NFIA walk is the first of three walks successful businessman and immediate couple were completing the Three Capes to raise money for research at QBI and past-president and patron of the National Walk to raise money for the Queensland GMRF, with the aim of raising $500 000 in Fire Industry Association (NFIA), and his Brain Institute in 2018. On that walk, Liz three years. The donation from the NFIA wife, Liz, QBI was the joint-recipient of a suggested to Brian that as the patron of walk will help QBI’s research into motor donation of over $250 000 in 2019. This the National Fire Industry Association, neurone disease, dementia, Parkinson’s incredible effort was the result of the NFIA he could create his own patron’s walk for disease, stroke and QBI’s Discovery Patron’s Walk held in October, which may charity. Mr Davies believes that corporate Research Endowment fund, which enables sound like a scenic walk in the park but Australia has a big responsibility to give fundamental research into major health Brian, Liz and seven other NFIA members back, which is testament to the success issues, including depression, anxiety, PTSD spent three days enduring driving rain and of the inaugural walk. The money raised and epilepsy. QBI is extremely grateful to winds of close to 50 knots coming straight was shared between the Queensland Brain Brian and Liz and the NFIA team for their off Antarctica. Institute and the Gallipoli Medical Research support in 2019. Foundation.

In 2019, the National Fire Industry Association (NFIA) Australia Patron’s Annual Walk for Charity, along the Great Ocean Walk, raised over $125 000 to support priority research at the Queensland Brain Institute (QBI) at The University of Queensland (UQ). 18 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Since 2014, The Stafford Fox Medical Research Foundation has supported healthy ageing and stroke-induced dementia research at QBI, donating $8.5M. Paul (Stafford Fox Foundation Trustee) and his wife, Susan, visited QBI in October, 2019, to meet with Professor Pankaj Sah (QBI Director) and Dr Steven Zuryn and Emeritus Professor Perry Bartlett AO (back row).

The Stafford Fox Medical Research Foundation

In 2019, The Stafford Fox Medical Research particularly dominant personality. He rose remaining on several boards until 1985. Foundation confirmed its continued from a position as a junior clerk at the Port By 1990, he was in poor health, suffering, generous support of the prestigious Melbourne depot of the Commonwealth among other things, from dementia. He $2.5 million philanthropically funded Oil Refineries (COR) in 1932, to become entered a nursing home and died in 1994. international fellowship to Dr Steven Zuryn the first Australian chief executive of By that time, he had already charted the at the Queensland Brain Institute to fight BP Australia Ltd in 1971. In World War II, course that would lead to the establishment stroke-induced dementia, also known as Stafford served in New Guinea where, in of the foundation. Moyna lived on Research vascular dementia. The Foundation also 1944, he was mentioned in despatches for for more than 18 years, knowing what continues to support the work of Emeritus bravery. He contracted malaria and spent would happen after her death, but never Professor Perry Bartlett’s research into many months recuperating in Melbourne revealing it publicly. Eventually, she too prevention of dementia in ageing by but his military service triggered qualities succumbed to dementia and died in 2013. improving cognition through exercise. of leadership and marked the beginning The couple, who were so careful with their of a steady rise in the business world, and money and who clearly had no desire for The Stafford Fox Medical Research of careful investment in the future. One of fame and prominence during their lifetime, Foundation was established in 2013 his first partners was John Holland, later will now forever be remembered for their following the death of Moyna Fox, and named in honour of her late husband, to become Sir John Holland AC, founder generosity in setting up the Stafford Fox James Stafford Fox, a former BP Australia of one of Australia’s great engineering and Medical Foundation. construction firms, involved in building chief executive. Stafford and Moyna The Foundation’s support of QBI is crucial the Snowy Mountains Scheme, Parliament Fox started one of Australia’s wealthiest in enabling Emeritus Professor Bartlett House and many other projects. Stafford medical research foundations after many and Dr Steven Zuryn to continue their Fox was a colleague of Holland’s in the years of careful planning, resulting in a fund work in finding solutions for the growing army in Darwin, and an early investor in worth over $100 million. It was only publicly challenge of dementia today. This cutting- Holland’s business, serving as a director for revealed in Moyna’s will when she died in edge research is helping put Queensland 36 years from 1949. 2013, many years after her husband. and Australia at the forefront of world James Stafford Fox was a private person, Stafford spent three years at the helm of medical research. tall, physically imposing, but without a BP Australia, and retired in 1974 at age 60,

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 19 2019 Donors

Bequests Lions Club of Brisbane Felicia Austin Pushpa Cherukuri Susan Edwards Camp Hill Kate Austin Tony Cheung Carmel Elmore Carindale Inc. QBI expresses its sincere Ada Avendano-Bernardo Tracey Chieng Eugene Esmonde Lions Club of Brisbane appreciation for the Metropolitan Inc. Serena Bagley Sin Yee Chow William Evans charitable bequests Maclean Distributors Pty Ltd Natasha Bain Siu Chow Keith Evans received from estates Macquarie Group Foundation Ariel Baker Kay Christensen Di Ezzy in 2019. Metro North Hospital and Health Tom Barker Ann-Louise Clay John Fairbairn Service David Barrett Lavinia Codd Clifford Farmer OAM Principal Gift – Morgans Foundation Rachel Barton Edwin Codd AM and Robyn Farrell Nicol Foundation Meredith Baxter Kathy Codd Susan Ferguson Organisations Order of the Eastern Star, Pauline Beames Diana Coghill Grant Ferrington The Brazil Family Foundation Glenmore Chapter No 170 Katherine Beatson William Coman AM Robert Fitchew The Stafford Fox Medical Philip Bacon Galleries Becky Beck Dominic Condon Shaun and Juliana Flanigan Research Foundation PwC Australia Peter Bell Jill Corrigan Judith Foote Recycling Metal Industries Pty Jerry Benetatos Bahriye Coskun Greg Frankish Limited Major Gifts – Alan Bennett Diogo Costa Robert Franklin Romac Investments Pty Ltd Joan Best Ingrid Costello Judy Frost Organisations Royal Brisbane and Women's Morgan Bignell John Coulson Roderick Frowd Josef Reisinger Foundation Hospital Foundation Gemma Blake Christine Cowell Angela Galantai Medtronic Australasia Pty Ltd Sea World Research & Rescue Foundation Jonathan Blessing James Cowin Jacque Garcia Metal Manufactures Limited Shell QGC Pty Ltd Anthony Blue Robyn Craig Adriana Garzarella The Clem Jones Foundation Siemon Investments Pty Ltd Neil and Alison Boland Carla Crether Roslyn Gaskell The Donald and Joan Lindsay Cribb Wilson Foundation St Andrew's War Memorial Adriana Bonelli Lorraine Gaunt Hospital Kate Crittenden The MND and Me Linda Boult Alison Gibb Stage Five P/L ATF Stage Foundation Limited John Bowden Timothy and Elaine Crommelin Ben Gillespie Five Trust The Terry and Maureen Bob Bower Suzanne Crook Matt Gisler The Flight Centre Foundation Hopkins Foundation David Cruickshanks-Boyd Trust Margaret Bowman Bruce Glover Thornton Foundation Robert and Janet Curgenven The Green Edge Suzanne Boyce Brenda Gooding Diana Dal Bon The John and Barbara Hay Noel Boycott Ruth Gough Organisations Philanthropic Foundation Christopher Bradshaw Cuc H Dang Thomas Graham Anonymous Donors (11) The McCusker Charitable Michael Brady John Dashwood Daniel Green Foundation ARA Fire Mark Brannigan Marian Davies Pip Green The Rotary International District Australia Post Timothy Bredy Monika Davies Nev Griffiths 9640 Ltd Australian Executor Trustees Jennifer Brennan Alexandra Davies Ross Grimley The University of Queensland in Foundation Lynette Davis, in America, Inc. Elizabeth Brennan The Late Donald Grimley Bayside Women's Social Club Memory of Col Davis The Wilgarning Trust Ruth Browne Julie Guy BICARE Inc. David de Feudis The Yulgilbar Foundation Joan Bryan AO Stephen Haddan CNGBio Corp Graham De Gruchy Tyack Health Pty Ltd Rithvik Buddhavarapu Francis Halim Crommelin Family Foundation James De La Hunty UQ Paediatric Society Alison Burgess Catherine Hall David Merson Foundation Ron De Pauuw WorkCover Queensland Kylie Burnett Judith Hamilton Emergency Services Charity Hamish Dee Wynnum 60 & Better Hilary Bustillo Kim Hardacre Golf Day Michael Delahunty Programme Inc. Jacqueline Byrne Peter Harford Equity Trustees Limited Asli Demir Sarah Byrnes Sharon Harley Golden Valley Keperra Lions Mary Denver Donors Tracy Campbell Jennifer Harvey Club Inc. Rebecca Deuble Terence Campbell Dylan Hassan Goodman Foundation Caroline Acton John Di Mauro Yvonne Campbell Ruby Helland Heart Strata Pty Ltd Jo Adams Leonie Dickson-James Judith Cantrell David Helland Hino Australia David Adsett David Disley Patricia Carbis Gregory Henricks HMcCooey Pty Ltd Desmond Allan Ross Dixon Constantine Carides Jeffrey Herse HopgoodGanim Lawyers Michelle Allan Raymond Dodd Carla Caro John Heussler AM Ipswich Hospital Foundation Betty Anderson Teisha Doherty Susan Cassidy Margaret Hibbs Lavinia's Ladies Lunch John Andrew Russell Draper Organising Committee Megan Cassidy-Welch Margot Hickey John Armitt Van Chung Duong Lexus of Brisbane (Corporate) Barnaby Casson Jan Hickey Catherine-Anne Armstrong Catherine Dwyer Lifestyle Mentor Services Annette Chacos Jan Hickling Benjamin Armstrong Ann Dyne Lioness Club of Palm Beach John Aukes Tim Chappell Robyn Hilton Currumbin Phil Ebinger

20 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Mary Hilton Yves Leenaerts Ainslie Murdoch Maureen Robbins Kate Turner Lindsay Hollingworth Aneta Leitner Malcolm Murray Leona Romaniuk Jenefer Turtle Tracey Hopkins Maxwell Lennox John Murray Anthony Rooney Alexis Tyler Nadine Hoskins Linda Levett The Late Mervyn Nargar Christine Rudolph Rosemary Udell Felice Houlihan Nerida Lewis Scott Naude Irene Ruscigno Cornelis Van Eldik John Houston Maija Liiv Judith Nedderman Janice Rushworth Dominique Verkerk Tonnia Hubbard Trent Lincoln Raeann Newson Beth Sanders Isabel Vidot Vanessa Hughson Steffanie Linde-Balko A Nielsen Alexander Sawtell Richard Wallace-Barnett Debra Hunter Stuart Lindenmayer Robert Nitz Janine Schmidt AM Sue Waller Ashley Hunter Adrian Lloyd John Nolan Mark Schroder Bruce Wallis Noyce Hurst Georgina Loakes Emily Nourse Kate Scott Jenny Wang Holly Husel Ryan Locke Phillip Nyssen Kate Scriven Zi Wang Alexandra Hutchinson Sarah Longbottom Michael Oakes Daniel Scriven Yun Wang Heidi Hynd Fay Love Simon O'Brien Rebecca Seth Xinhua Wang Colin Ingram Warren Low Jessica O'Brien Peter Sharry Michael Waring Rebecca Jackson Beryl Lynagh Thomas O'Connor Leila Shuffler Stuart Watt Harmony James Mary Lyons Jaime O’Donovan John Siemon Garry and Gaye Waugh Elizabeth Jameson Robert and Pam MacDonnell Maureen O'Driscoll Catherine Simons Jessica Weatherall Abdul Jarrah James MacDonnell Ruth O'Hanlon Roger Simons Nicole Weatherley Dev Jegatheesan Craig Maclean Jessica O'Loughlin Rodney Skilton Jonathan Webber Stephanie Jillett Jeff and Fran Maclean Ong Family Debbie Smart Guyatt West Ronald Johnson Hilda Maclean Andy Opanowycz Anthony Smith Charlotte West Eddie Johnstone Daphne Maclean Narelle O'Shanesy Kim Smith Kate Weston Jamie Jones Annie Macnaughton Gabrielle O'Shea Dorothy Smith Ja Wheatley Ellie Jones Peter Madsen Peter O'Sullivan Ian Smurthwaite Wendy Whitby Steven Jones Christine Mah Jenette Otter Stephen Smykowsky Darryl White Annie Jordan King Mak Peter Paine Ann Spargo Janice Wilke Paige Karklis Sarah Manson Jodie Paine Robyn Stagg Margaret Wilkins Lee Kemp Pamela Mar Fan Suzanne Parker Elke Stapf Greg Willcox Jennifer Kennedy Giles Markey Johanne Parsons Dr Margaret Steinberg AM and Kym Willey Geoffrey Kent Andrea Markey Francesca Paterson Richard Steinberg Clive Williams OAM Ruth Kerr OAM Janice Marshall Sharon Payne Brigit Steindl Caroline Williams Helen Kerr Barrie Mawby Graeme Pearce Glenn Stephenson Darryl Woodrow Bobby Ketchersid CPA Gail McCallum Erin Pearl Maureen Stevenson Peter Woodward Anne Keys Donald McClintock Jill Penridge Kevin Stewart Cameron Worley Nur Khan Elizabeth McCowan Andrew Pentland Fiona Stewart Lorinda Wright Judith Kincade Margaret McDonald Andy Perry Edward Stoios Christopher Wright Jerusha King Margaret McGregor Suzie Phillips Rachael Stowasser Irene Yii Steven Kirby Moya McKenzie Clare Phillips Lloyd Studders Andrew Young Yvonne Kirkegard Alana McLelland Karen Platz Leanne Sturgess Billy Young Terrence Kitchin Cath McMurchy Glenda Powell AM Lois Sullivan Frank and Patsy Youngleson Janice Kluck Jason McNamara Andrea Powell Geoffrey Swartz Nikki Zarboutis Ashley Knapp Alex & Mary Milanovic Ayla Prater Hayley Symington Li-Hui Zheng Helen Komoff Steven Miles MP Beverley Quinn Roger Tarrant Neil Zouaoui Maria Kravchenko Peter Millar Judy Quintal Aimee Thomson Jeannette Zubevich Amadeo Kuypers John Miller Linda Rahrs Jacob Tilse Sandra Lacey Lesley Mills Camille Rains Johnson Anne Tobin Anonymous Jeanette Lamont Guy Mitchell Joady Raph Heather Todd William Lanagan John Morris Philip Reeves Anthony Toohey donors Manus Lang Kelly Morrow Suzie Reid Fiona Treadwell A sincere thank you to Noel Langford David Muir Colin Rendell Elise Treleaven our donors who prefer Steve Trevor Nikki Langton Andrew Muir Brooke Reynolds to remain anonymous. Kamyra Laurenson Teresa Muir Nicholas Reynolds Janet Trevorrow Joan Lawrence AM Bevan Muldoon Margaretha Ridder Margaret Trigger Roderick Lee Monica Mullins David Ritchie Gracie Troy Betty Lee Cat Mullins Katherine Robbins Theodore Tsagris

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 21 How to support the Queensland Brain Institute

Donations Bequests There are many ways in which you can help By leaving a bequest to QBI in your will, Under current legislation, gifts to the support QBI’s research effort, including: you are leaving a lasting legacy that Queensland Brain Institute are tax accelerates current research and preserves deductible. To discuss how you can • Make a donation for a specific future projects. Bequests can include: support the Institute, please contact us at: research area • Make a donation for the purchase of • A percentage of an estate Queensland Brain Institute scientific equipment • The residuary of an estate (what Building #79 remains after all other gifts and costs • Fund scholarships for talented students The University of Queensland have been deducted) • Provide fellowships for early- to mid- St Lucia QLD 4072 career scientists • A gift of a specific sum of money Telephone: +61 7 3346 6413| • Support Professorial Chairs • A particular asset, such as Facsimile: +61 7 3346 6301 property, works of art, shares, Email: [email protected] • Undertake laboratory dedications or an insurance policy. Website: qbi.uq.edu.au • Provide gifts in memoriam • Fundraise using the community fundraising platform Everyday Hero.

22 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Public and scientific engagement

Queensland Brain Institute's Associate Professor Bruno van Swinderen presented on “The science of sleep” as part of T he University of Queensland Global Leadership Series in March, 2019.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 23 Public engagement

Our public engagement gives us the chance to inform the community about our research, educate the public on the importance of neuroscience research and create a shared sense of pride in what we are achieving in Australia with their support. We also find that bringing people through our laboratories, or sending scientists into the community, can result in our researchers feeling a renewed sense of purpose and inspiration in their work. In 2019, our public engagement spanned named lectures, community events and talks and tours through the QBI laboratories. We once again held a series of breakfasts covering research into motor neurone disease, artificial intelligence, stroke and dementia. Another annual highlight is hosting rounds of the Australian Brain Bee. Established by Professor Linda Richards, our Deputy Director (Research), in 2006, these events challenge some of the nation’s brightest school students to learn more about the brain, as well as neuroscience research and careers. Some of the top-performing students then undertook work experience in our laboratories later in the year. With previous winners going on to join us as research students, the Brain Bee is a very valuable opportunity for both QBI and the students.

Peter Goodenough Memorial Lecture

One of the highlights of our In 2019, we were privileged to now the host of ABC Radio National’s engagement calendar each year is welcome Dr Norman Swan to deliver The Health Report, which is the the Peter Goodenough Memorial the lecture. Dr Swan is one of world’s longest-running health Lecture, which recognises the Australia’s leading health program in the English-speaking generosity of Peter Goodenough in communicators, who combines mass world. Dr Swan has won numerous leaving a bequest to establish an public appeal with rigorous awards, including the nation’s top MND research laboratory. credentials. A former clinician, he is prize for journalism, the Gold Walkley. In his lecture, which drew an audience of scientists, clinicians and community, Dr Swan explored key features of medical research: serendipity, curiosity and goal-driven. He discussed the balance of curiosity-driven research versus goal-oriented investigation and how we ensure that both can be accommodated to provide effective prevention, cures and new treatments. Dr Swan also covered the expectations of donors, and how philanthropy could enable such research, now and into the future. The captivating talk also included anecdotes from his time in media, including as medical consultant for Dr Norman Swan, Professor Pankaj Sah and co-trustees of the Peter Goodenough Bequest, Mr Clive Jackson and Mr Neil Matheson reality show The Biggest Loser.

Memorial Celebration of Emeritus Professor Jack Pettigrew’s Life in Science

We were privileged to host a memorial Berkeley, Caltech, his leadership of National was hailed as inarguably one of the great celebration for Emeritus Professor Jack Vision Research Institute of Australia in polymaths, interested in a range of topics Pettigrew, who passed away suddenly in Melbourne, and then his appointment as a that extended in his retirement to rock art May. The celebration, which was held in Professor of Physiology and head of UQ’s and baobab trees, of which he discovered a October, brought together family, past Vision, Touch and Hearing Research Centre, new species in 2012. colleagues and students to pay tribute. the first ARC centre funded in Queensland. Thanks to everyone who attended in Jack was a world-leading neuroscientist Also highlighted was Jack’s love of the person and virtually, particularly those with a colourful personality who made bush and his passion for hiking and rock who spoke: Tara Kurrajong, Chloe seminal discoveries in vision including the climbing – he was one of the first people Callistemon, Pankaj Sah, Perry Bartlett, neural basis for binocular vision, and was a to explore some of the Blue Mountains Takuji Kasamatsu, Justin Marshall, Olivia Fellow of both the Royal Society of London canyons, and made the first ascent on Carter, Donald Mitchell, Valerie Beral, Susan and the Australian Academy of Science. many rock climbs, including being part Pond, Chris Wildsoet, Trung Ngo, Herbert of the first group to climb Ball’s Pyramid, Speakers reflected on aspects of Jack’s Huppert, Rama Vilayanur, Paul Martin, John the world’s tallest volcanic stack. Jack life including his time at medical school, Drennan and Claudia Vickers.

24 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Named Lectures Peter Goodenough Memorial Lecture Dr Norman Swan ABC Radio National 20 August

Community events and talks Research tours of QBI Centacare Community AI Breakfast Lions Club of Capalaba National Youth Science Services 12 June 8 October Forum 5 March 11 & 15 January Clem Jones Centre for QBI Director’s Donor Gossips Aphasia Group Ageing Dementia Roundtable Lunch MND tour 6 March Research Public 15 October 14 & 19 February Dementia Forum Scifleet tour International Women’s 3 July St Margaret’s WNB Day panel discussion Cocktail Event 13 March 8 March U3A talk 17 October Pine Rivers Rotary Group 8 July tour Brain Bee Round 1 2019 National Fire 16 April 13 March Rotary Club of Stones Industry Association Corner Great Ocean Road UQ Staff Donors tour Global Leadership Series 15 July Charity Walk 23 May – The science of sleep 17 – 21 October Donor tours Preventing Dementia 19 March 20, 26 & 27 June Forum – Redlands Stafford Fox Boardroom MND breakfast 15 July Lunch Scientist for a Day 3 April 21 October 21 June Brain Bee Round 2 Kate Jones MP tour Hand Heart Pocket Gala 17 July Morgans Morning Tea 11 July 26 April 23 October Lavinia’s Ladies Golf Day in support of Ross Vasta MP and Dementia Luncheon MND Thank you Friendly Group Wynnum tour MND and dementia 2 August morning tea 18 July 28 April 30 October Ross Maclean Race Day Ted Sorenson MP tour Souths vs Sunnybank 24 August Wynnum Manly and 29 July rugby match in support District Men’s Shed talk Healthy Brains tour of MND Bridge to Brisbane fun 6 November 2 May run 22 August 25 August Lions Club Brisbane Inner Rotary Club of Brisbane Rotary Club of Brisbane North talk Mid-City tour Mid-City talk Pier Apartments 12 November 30 August 10 May Residents Group talk 2 September McKinney’s Morning Tea Peak Partnership APCN Patient 13 November Directors tour Information Session Coming of Age: 2 September 13 May, 13 July A symposium on PriceWaterhouseCoopers event Brain Bee Work Experience cannabis and the brain Placements QBI Director’s Donor 4 September 14 November Roundtable Lunch 24 September – 8 October Churchie Cricket Lunch Stroke Week Breakfast 14 May 20 November Lord Mayor Adrian Schrinner 5 September tour HopgoodGanim talk 1 October 20 May Bardon Lions Club talk 26 September Churchie Tour White Label Noba launch 29 October Dementia Breakfast 27 May Sallyanne Atkinson’s Bridge 2 October Brisbane Club talk to Brisbane supporters tour 18 November 30 May Bayside Ladies Social Club talk Queensland Symphony QBI Alumni Breakfast 3 October Orchestra tour 1 June 3 December Koda Financial tour 3 December

Scientific seminars and symposia QBI/Mater Research Symposium SLRC Symposium – 12 October The Science of Learning: An Evidence Base to Education Australian C. elegans Symposium in the 21st Century 23-25 October 1-2 November

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 25 Scientific engagement

Our scientific events and seminars play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of hosting events for the scientific community is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Assistant Professor Christian Frøkjær-Jensen from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, at the Australian C. elegans Symposium.

26 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Scientific seminars & symposia

Neuroscience Seminars

Associate Professor Jeremy Dittman Professor Elly Nedivi Professor Tod Kippin Dr Asheeta Prasad Cornell Medical School, New York, Massachusetts Institute of University of California, Santa University of New South Wales USA Technology, USA Barbara, USA Neural modulation of dopamine Molecular control of synaptic Visualizing molecular events in There’s an Ap(tamer) for that! A networks vesicle fusion synapse formation in vivo generalizable biosensor platform for evolving pharmacological and Professor Naomi Wray Associate Professor Bruno van Associate Professor Tom Burne neuroscience research Institute for Molecular Bioscience Swinderen Queensland Brain Institute, and Queensland Brain Institute, The Queensland Brain Institute, The University of Queensland Professor Alice Pebay University of Queensland The University of Queensland The role of vitamin D in the adult The University of Melbourne Progress in ALS genomics research Understanding general anaesthesia: brain Modelling neurodegeneration using from the Ice Bucket Challenge why loss of consciousness is patient induced pluripotent stem Grant interesting Dr Matilde Balbi cells University of British Columbia, Professor Steven Petrou Kiaran Lawson Canada Professor Amparo Acker-Palmer Florey Institute of Neuroscience and Queensland Brain Institute, Activity dependent neuroprotection Goethe University, Germany Mental Health, The University of The University of Queensland in the acute phase after stroke Neurovascular interactions during Melbourne From bugs to bots: examining CNS development Precision medicine in genetic insect flight behaviour for potential Professor Nancy Kanwisher epilepsies: have we arrived? robotic applications Massachusetts Institute of Professor Jürgen Götz Technology, USA Queensland Brain Institute, Dr Zhaoyu Li Dr Alexandra Grubman Functional imaging of the The University of Queensland Queensland Brain Institute, Monash University human brain: A window into the From basic mechanisms to The University of Queensland Distinct microglial phenotypes in architecture of the mind antibody- and ultrasound-based Functional connectomics: Alzheimer’s disease are controlled therapeutic interventions for understanding neural network by amyloid plaque phagocytosis Professor Michael Hausser Alzheimer's disease integration in C. elegans University College London, UK Dr Martin Smith All-optical closed-loop Professor Geoff Goodhill Professor Fred Meunier Garvan Institute of Medical Research, manipulation of neural circuits in Queensland Brain Institute, Queensland Brain Institute, Going beyond the basepair with vivo The University of Queensland The University of Queensland nanopores The development of neural coding Dynamic nanoscale organisation Dr Michael Lazarou in zebrafish, and a new method for of the neurotransmitter release Associate Professor Naotsugu Monash University analysing calcium imaging data machinery Tsuchiya Culling bad mitochondria: The Monash University molecular mechanisms of PINK1/ Associate Professor Zachary Knight Dr Adam Walker Conscious perception and its neural Parkin mitophagy University of California, San Francisco, Queensland Brain Institute, substrate: integration and dynamics USA The University of Queensland Dr Tim O’Shea The neurobiology of homeostasis Mechanisms of neurodegeneration Dr Laura Gumy University of California, Los Angeles, and neuroprotection in motor University of Otago, New Zealand USA Professor Gord Fishell neuron disease and frontotemporal MAP2-dependent regulation of Bioengineering neural repair in the Harvard Medical School, USA dementia axonal transport central nervous system Making up your mind, the specification and integration of Professor Oliver Hobert Professor Luis Puelles Dr Albert Lee interneurons into the cortex Columbia University, New York, USA University of Murcia, Spain Macquarie University Homeoboxes build the C. elegans An introduction to the prosomeric Application of proteomics to Dr Eva Hoch nervous system model characterise mechanisms of Ludwig-Maximilians-Universität, neurodegenerative disease Germany Professor Hollis Cline Dr Dorit Kliemann Cannabis: Potential and Risks. A The Scripps Research Institute, USA Caltech, USA Dr Dimitri Perrin scientific analysis Brain development and plasticity: Functional brain networks in Queensland University of Technology using developmental plasticity hemispherectomy Whole-brain 3D imaging and Professor Warwick Bowen mechanisms to rehabilitate the quantitative analysis School of Mathematics and Physics, injured brain Dr Graham Murray The University of Queensland Institute for Molecular Bioscience, Associate Professor Jared W. Young Quantum and precision sensing: Associate Professor Mazen Kheirbek The University of Queensland University of California, San Diego, advances and applications in the University of California, San Francisco, USA From dopamine to delusions – what USA biosciences is the evidence for the predictive Delineating potential mechanisms Encoding of emotionally relevant coding account of schizophrenia? underlying bipolar disorder using Dr Rodrigo Suarez stimuli in hippocampal circuits cross-species testing Queensland Brain Institute, Professor John Nurnberger The University of Queensland Professor Subhojit Roy Indiana University School of Medicine, Professor Helen Cooper Clues from the past: marsupials University of California, San Diego, USA USA Queensland Brain Institute, reveal new principles of Unusual trafficking Routes in axonal transport Emerging themes in the genetics of The University of Queensland evolutionary, developmental and bipolar disorder Understanding the molecular systems neuroscience origins of cortical malformations Professor Preben Bo Mortensen Dr Victor Anggono Aarhus University, Denmark Queensland Brain Institute, The University of Queensland iPSYCH: studying nature and nurture in mental disorders in Molecular mechanisms of Denmark glutamate receptor trafficking

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 27 Publication List

QBI publications (peer-reviewed journal articles, books, book chapters, conference papers) appearing in 2019 either as epublications or in print. Some epublications have appeared in print in 2020 and have been updated to reflect this.

1. Abdellaoui A et al. (2019) Genetic correlates 13. Atif M et al. (2019) GluClR-mediated inhibitory 25. Bland NS & Sale MV (2019) Current challenges: of social stratification in Great Britain.Nature postsynaptic currents reveal targets for the ups and downs of tACS. Experimental Brain Human Behaviour 3: 1332–1342. ivermectin and potential mechanisms of Research 237: 3071-3088. ivermectin resistance. PLoS Pathogens 15: e1007570. 2. Abramson D et al. (2019) Book Chapter: A 26. Blauwendraat C et al. (2019) Parkinson’s cache-based data movement infrastructure disease age at onset genome-wide association for on-demand scientific cloud computing. In 14. Australian Brain Alliance et al. (2019) A study: Defining heritability, genetic loci, and D Abramson & BR de Supinski (Eds.), Super neuroethics framework for the Australian Brain α-synuclein mechanisms. Movement Disorders Computing Frontiers (pp. 38-56). Cham, Initiative. Neuron 101: 365-369. 34: 866-875. Switzerland: Springer International Publishing. 15. Autuori E et al. (2019) rSK1 in rat neurons: a 27. Bond TA et al. (2019) Exploring the role of 3. Adams AG et al. (2019) The relationship controller of membrane rSK2? Frontiers in genetic confounding in the association between between social cognitive difficulties in the acute Neural Circuits 13: 21. maternal and offspring body mass index: stages of stroke and later functional outcomes. evidence from three birth cohorts. International Social Neuroscience – 15: 1–12. Journal of Epidemiology 49: 233–243. 16. Badcock JC et al. (2019) Loneliness in psychotic illness and its association with cardiometabolic 4. Adams SD et al. (2019) Development of a disorders. Schizophrenia Research 204: 90-95. 28. Boskovic Z et al. (2019) Regulation of miniature device for emerging deep brain cholinergic basal forebrain development, stimulation paradigms. PLoS One 14: e0212554. connectivity and function by neurotrophin 17. Bamford RA et al. (2020) The interaction receptors. Neuronal Signaling 3: NS20180066. between contactin and amyloid precursor 5. Al-Amin M et al. (2019) Vitamin D deficiency is protein and its role in Alzheimer’s Disease. associated with reduced hippocampal volume Neuroscience 424: 184-202. 29. Boyd Taylor HG et al. (2019) Vascular effects and disrupted structural connectivity in patients on the BOLD response and the retinotopic with mild cognitive impairment. Human Brain mapping of hV4. PLoS One 14: e0204388. 18. Barbu MC et al. (2019) Association of Mapping 40: 394-406. whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for 30. Brennan FH et al. (2019) Complement receptor 6. Al-Amin Md et al. (2019) Adult vitamin D Major Depressive Disorder and white matter C3aR1 controls neutrophil mobilization following deficiency disrupts hippocampal-dependent microstructure in the UK Biobank. Biological spinal cord injury through physiological learning and structural brain connectivity in Psychiatry: Cognitive Neuroscience and antagonism of CXCR2. JCI Insight 4: e98254. BALB/c mice. Brain Structure and Function 224: Neuroimaging 4: 91-100. 1315-1329. 31. Brownsett SLE et al. (2019) Language deficits 19. Barker MS et al. (2020) Idea formulation for following dominant hemisphere tumour 7. Ali A et al. (2019) Developmental vitamin D spoken language production: The interface resection are significantly underestimated deficiency produces behavioral phenotypes of cognition and language. Journal of the by syndrome-based aphasia assessments. of relevance to autism in an animal model. International Neuropsychological Society 26: Aphasiology 33: 1163-1181. Nutrients 11: 1187. 226-220. 32. Byrne EM et al. (2019) Sleep disorders and 8. Andlauer TFM et al. (2019) Bipolar multiplex 20. Bates TC et al. (2019) Social competence risk of incident depression: a population families have an increased burden of common in parents increases children’s educational case-control study. Twin Research and Human risk variants for psychiatric disorders. Molecular attainment: replicable genetically-mediated Genetics 22: 140-146. Psychiatry – doi: 10.1038/s41380-019-0558-2. effects of parenting revealed by non- transmitted DNA. Twin Research and Human 33. Cao Y et al. (2019) Neural and behavioral Genetics 22: 1-3. 9. Andreazza AC et al. (2019) Book Chapter: markers of observed pain of older adults. Mitochondrial function and inflammation Neuropsychologia 131: 84-90. pathways in the neuroprogression of mental 21. Bauer AE et al. (2019) Genetic risk scores for disorders. In F Kapczinski et al. (Eds.), major psychiatric disorders and the risk of 34. Carroll A et al. (2019) Changes in science Neuroprogression in Psychiatry (pp. 272). postpartum psychiatric disorders. Translational attitudes, beliefs, knowledge and physiological Oxford: Oxford University Press, UK. Psychiatry 9: 288. arousal after implementation of a multimodal, cooperative intervention in primary school 10. Arnau-Soler A et al. (2019) Genome-wide by 22. Baumann O et al. (2019) Survival of the fittest: science classes. Information and Learning environment interaction studies of depressive increased stimulus competition during encoding Sciences 120: 409-425. symptoms and psychosocial stress in UK results in fewer but more robust memory traces. Biobank and Generation Scotland. Translational Frontiers in Psychology 10: 21. 35. Chang L-H et al. (2019) Association between Psychiatry 9: 14. polygenic risk for tobacco or alcohol 23. Berning BA & Walker AK (2019) The consumption and liability to licit and illicit 11. Ashton MM et al. (2019) The therapeutic pathobiology of TDP-43 C-terminal fragments in substance use in young Australian adults. Drug potential of mangosteen pericarp as an ALS and FTLD. Frontiers in Neuroscience 13: 335. and Alcohol Dependence 16: 271-279. adjunctive therapy for bipolar disorder and schizophrenia. Frontiers in Psychiatry 10: 115. 24. Billette OV et al. (2019) The concept of 36. Chaturvedi V et al. (2019) Loss of Neogenin1 regularization: resolving the problem of in human colorectal carcinoma cells causes 12. Atif M et al. (2019) The effects of insecticides surface dyslexia in semantic variant primary a partial EMT and wound-healing response. on two splice variants of the glutamate-gated progressive aphasia across different languages. Scientific Reports9: 4110. chloride channel receptor of the major malaria Neuropsychology: 34: 298–307. vector, Anopheles gambiae. British Journal of Pharmacology 177: 175-187.

28 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Journal cover from Evans HT et al.(74).

37. Chauhan G et al. (2019) Genetic and lifestyle 60. Degenhardt L et al. (2019) Concordance risk factors for MRI-defined brain infarcts in between the diagnostic guidelines for alcohol a population-based setting. Neurology 92: and cannabis use disorders in the draft ICD-11 E486-E503. and other classification systems: analysis of data from the WHO’s World Mental Health Surveys. Addiction 114: 534-552. 38. Chen KS et al. (2019) Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. Journal of 61. Degenhardt L et al. (2019) Association of Neurooncology 146: 41-53. cohort and individual substance use with risk of transitioning to drug use, drug use disorder, and remission from disorder: Findings from the 39. Chen X et al. (2019) Accelerated estimation World Mental Health Surveys. JAMA Psychiatry and permutation inference for ACE modeling. 76: 708-720. Human Brain Mapping 40: 3488-3507.

62. Degenhardt L et al. (2019) The epidemiology of 40. Cheney KL et al. (2019) An Ishihara-style test drug use disorders cross-nationally: Findings of animal colour vision. Journal of Experimental from the WHO’s World Mental Health Surveys. Biology 222: jeb189787. International Journal on Drug Policy 71: 103-112.

41. Choi KW et al. (2019) Assessment of 50. Cummins N et al. (2019) Disease-associated 63. Demontis D et al. (2019) Discovery of the first bidirectional relationships between physical tau impairs mitophagy by inhibiting Parkin genome-wide significant risk loci for attention activity and depression among adults: a translocation to mitochondria. EMBO Journal deficit/hyperactivity disorder.Nature Genetics 2-sample Mendelian randomization study. JAMA 38: e99360. 51: 63–75 Psychiatry 76: 399-408. 51. Czamara D et al. (2019) Integrated analysis of 64. Dickinson JE et al. (2019) A new visual illusion of 42. Chuang KH et al. (2019) Evaluation of nuisance environmental and genetic influences on cord aspect-ratio context. Vision Research 165: 80-83. removal for functional MRI of rodent brain. blood DNA methylation in new-borns. Nature NeuroImage 188: 694-709. Communications 10: 2548. 65. Ding Y et al. (2019) Neural Evolution of Context- Dependent Fly Song. Current Biology 29: 1089 43. Chundru VK et al. (2019) Examining the impact 52. Dalsgaard S et al. (2019) Incidence rates and – 1099.e. of imputation errors on fine-mapping using cumulative incidences of the full spectrum of DNA methylation QTL as a model trait. Genetics diagnosed mental disorders in childhood and 212: 577-586. adolescence. JAMA Psychiatry 77: 155-164. 66. Dissanayaka NNW et al. (2019) Depression symptomatology correlates with event-related potentials in Parkinson’s disease: An affective 44. Collin SP & Marshall NJ (2019) Neuroethology 53. Dang TTH et al. (2019) Cost-effectiveness priming study. Journal of Affective Disorders meets brain, behavior and evolution: promoting of deep brain stimulation with movement 245: 897-904. the study of the neural basis of behavior. Brain, disorders: a systematic review. Movement Behavior and Evolution 94: 5-6. Disorders Clinical Practice 6: 348–358. 67. Donato A et al. (2019) Neuronal sub- compartmentalization: a strategy to optimize 45. Connell M et al. (2019) A comparison of 54. Dang TTH et al. (2019) Economic evaluation of neuronal function. Biological Reviews 94: hallucinatory experiences and their appraisals in deep-brain stimulation for Tourette’s syndrome: 1023-1037. those with and without mental illness. Psychiatry an initial exploration. Journal of Neurology 266: Research 274: 295-300. 2997-3008. 68. Dudding T et al. (2019) Genome wide analysis for mouth ulcers identifies associations at 46. Conway ZJ et al. (2019) Alternate subthalamic 55. Davies G et al. (2019) Author Correction: immune regulatory loci. Nature Communications nucleus deep brain stimulation parameters Study of 300,486 individuals identifies 148 10: 1052. to manage motor symptoms of Parkinson’s independent genetic loci influencing general disease: systematic review and meta-analysis. cognitive function (Nature Communications, Movement Disorders Clinical Practice 6: 17-26. (2018), 9, 1, (2098), 10.1038/s41467-018- 69. Dutt M et al. (2019) The α1-adrenoceptor 04362-x). Nature Communications 10: 2068. inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports9: 47. Crew RC et al. (2019) Maternal vitamin D 17841. deficiency during rat gestation elicits a milder 56. Davila RA et al. (2019) A simple, web-based phenotype compared to the mouse model: repository for the management, access and Implications for the placental glucocorticoid analysis of micrographic images. Journal of 70. Dzafic I et al. (2019) Stria terminalis, amygdala, barrier. Placenta 83: 5-7. Molecular Histology 50: 573-580. and temporoparietal junction networks facilitate efficient emotion processing under expectations. Human Brain Mapping 40: 5382- 48. Cui Y et al. (2020) White matter microstructural 57. Day MA et al. (2019) An evaluation of the 5396. differences across major depressive disorder, behavioral inhibition and behavioral activation bipolar disorder and schizophrenia: A tract- system (BIS-BAS) model of pain. Rehabilitation based spatial statistics study. Journal of Psychology 64: 279-287. 71. Escobar-Camacho D et al. (2019) Color Affective Disorders260: 281-286. discrimination thresholds in a cichlid fish: Metriaclima benetos. Journal of Experimental 58. Day MA et al. (2019) Moderators of mindfulness Biology 222: jeb201160. 49. Cullen KR et al. (2019) Erratum: Intravenous meditation, cognitive therapy, and mindfulness- ketamine for adolescents with treatment- based cognitive therapy for chronic low back resistant depression: an Open-Label Study, pain: a test of the Limit, Activate, and Enhance 72. Evans HT et al. (2019) Decreased synthesis by Cullen KR, Amatya P, Roback MG, Albott Model. Journal of Pain 21: 161–169. of ribosomal proteins in tauopathy revealed CS, Westlund Schreiner M, Ren Y, Eberly LE, by non-canonical amino acid labelling. EMBO Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Journal 38: e101174. 59. Day MA et al. (2019) A pilot randomized Reigstad K, Horek N, Tye S, Lim KO, Klimes- controlled trial comparing mindfulness Dougan B. (J Child Adolesc Psychopharmacol meditation, cognitive therapy, and mindfulness- 73. Ewais T et al. (2019) Protocol for a pilot (2018) 28:7 (437-444) DOI: 10.1089/ based cognitive therapy for chronic low back randomised controlled trial of mindfulness- cap.2018.0030). Journal of Child and Adolescent pain. Pain Medicine 20: 2134-2148. based cognitive therapy in youth with Psychopharmacology 29: 77-77. inflammatory bowel disease and depression. BMJ Open 9: e025568.

QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 29 74. Feigin VL et al. (2019) Global, regional, and 101. Grove J et al. (2019) Identification of common national burden of neurological disorders, genetic risk variants for autism spectrum 1990-2016: a systematic analysis for the disorder. Nature Genetics 51: 431-444. Global Burden of Disease Study 2016. Lancet Neurology 18: 459-480. 102. Gunasinghe D et al. (2019) Mid-air conflict avoidance and recovery: an acceleration-based 75. Filmer HL et al. (2019) Accounting for individual approach for unmanned aircraft. IEEE Robotics differences in the response to tDCS with and Automation Letters 4: 2054-2061. baseline levels of neurochemical excitability. Cortex 115: 324-334. 103. Hahn A & Zuryn S (2019) The cellular mitochondrial genome landscape in disease. 76. Filmer HL et al. (2019) The efficacy of Trends in Cell Biology 29: 227-240. transcranial direct current stimulation to prefrontal areas is related to underlying cortical 104. Hahn A & Zuryn S (2019) Mitochondrial genome morphology. NeuroImage 196: 41-48. (mtDNA) mutations that generate reactive oxygen species. Antioxidants (Basel) 8: 392. 77. Filmer HL et al. (2020) Modulating brain activity and behaviour with tDCS: Rumours of its death 105. Hakulinen C et al. (2019) The association have been greatly exaggerated. Cortex 123: 141-151. between early-onset schizophrenia with employment, income, education, and 78. Firth J et al. (2019) The Lancet Psychiatry cohabitation status: nationwide study with Commission: a blueprint for protecting physical 35 years of follow-up. Social Psychiatry and health in people with mental illness. Lancet Psychiatric Epidemiology 54: 1343-1351. Psychiatry 6: 675-712. Journal cover from Linton C et al.(191). 106. Hamilton OKL et al. (2019) An epigenetic score 79. Fletcher LN & Williams SR (2019) Neocortical for BMI based on DNA methylation correlates topology governs the dendritic integrative with poor physical health and major disease in capacity of layer 5 pyramidal neurons. Neuron 90. Garrett A et al. (2019) Physiological and the Lothian Birth Cohort. International Journal 101: 76-90.e74. anatomical investigation of the auditory of Obesity 43: 1795–1802. brainstem in the Fat-tailed dunnart 80. Fogarty MJ et al. (2019) Size-dependent (Sminthopsis crassicaudata). PeerJ 7: e7773. 107. Han W et al. (2019) Shisa7 is a GABAA receptor vulnerability of lumbar motor neuron dendritic auxiliary subunit controlling benzodiazepine G93A degeneration in SOD1 mice. Anatomical 91. Ge D et al. (2019) A seasonal comparison of the actions. Science 366: 246-250. Record – 303: 1455-1471. neuromuscular junction morphology of Bufo marinus. Journal of Comparative Neurology 527: 108. Harold D et al. (2019) Population-based 81. Foldi CJ et al. (2019) Increasing paternal age 1931-1939. identity-by-descent mapping combined with alters anxiety-related behaviour in adult mice. exome sequencing to detect rare risk variants Genes, Brain and Behavior 18: e12522. 92. Ge D et al. (2020) What are neurotransmitter for schizophrenia. American Journal of Medical release sites and do they interact? Neuroscience Genetics Part B: Neuropsychiatric Genetics 180: 223-231. 82. Foo JC et al. (2019) Evidence for increased 425: 157-168. genetic risk load for major depression in patients assigned to electroconvulsive therapy. 93. Gibson EC et al. (2019) Initiation, inhibition and 109. Harris AM et al. (2019) Taking a closer look American Journal of Medical Genetics Part B: strategy generation across the healthy adult at visual search: Just how feature-agnostic Neuropsychiatric Genetics 180: 35-45. lifespan. Archives of Clinical Neuropsychology is singleton detection mode? Attention, 34: 511-523. Perception, & Psychophysics 81: 654-665. 83. Forner S et al. (2019) Intra- and extracellular β-amyloid overexpression via adeno-associated 94. Glanville KP et al. (2020) Classical human 110. Harris MG et al. (2019) Cross-national patterns virus-mediated gene transfer impairs memory leukocyte antigen alleles and C4 haplotypes are of substance use disorder treatment and and synaptic plasticity in the hippocampus. not significantly associated with depression. associations with mental disorder comorbidity Scientific Reports9: 15936. Biological Psychiatry 87: 419-430. in the WHO World Mental Health Surveys. Addiction 114: 1446-1459.

Val66Met 84. Franzmeier N et al. (2019) The BDNF SNP 95. Gonçalves NP et al. (2019) Peripheral nerve modulates the association between β-amyloid regeneration is independent from Schwann 111. Harrison WJ (2019) The (in)visibility of groomed and hippocampal disconnection in Alzheimer’s cell p75NTR expression. Frontiers in Cellular ski runs. I-Perception 10: 1-5. disease. Molecular Psychiatry – doi: 10.1038/ Neuroscience 13: 235. s41380-41019-40404-41386. 112. Harrison WJ (2019) Segmenting processes in 96. Gooch H et al. (2019) 1,25-dihydroxyvitamin the human lateral geniculate nucleus. Cortex 121: 85. Fraser J et al. (2019) Granule neuron precursor D modulates L-type voltage-gated calcium 485-487. cell proliferation is regulated by NFIX and channels in a subset of neurons in the intersectin 1 during postnatal cerebellar developing mouse prefrontal cortex. 113. Harrison WJ et al. (2019) Attentional selection development. Brain Structure and Function 224: Translational Psychiatry 9: 281. and illusory surface appearance. Scientific 811-827. Reports 9: 2227. 97. Götz J et al. (2019) Molecular pathogenesis of 86. Fraser J et al. (2020) Common regulatory the tauopathies. Annual Review of Pathology: 114. Harrison WJ & Rideaux R (2019) Voluntary targets of NFIA, NFIX and NFIB during postnatal Mechanisms of Disease 14: 239-261. control of illusory contour formation. Attention, cerebellar development. Cerebellum 19: 89-101. Perception, & Psychophysics 81: 1522–1531.

87. Friocourt F et al. (2019) Shared and differential 98. Götz JJ & Götz J. (2019). Experimental Models 115. Haworth S et al. (2019) Low-frequency features of Robo3 expression pattern in of Tauopathy – From Mechanisms to Therapies. variation in TP53 has large effects on head amniotes. Journal of Comparative Neurology In A Takashima et al. (Eds.), Tau Biology (pp. circumference and intracranial volume. Nature 527: 2009-2029. 381-391). Singapore: Springer Singapore Communications 10: 357.

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89. Gangolli M et al. (2019) Repetitive concussive 100. Grimm A et al. (2019) Mitochondria modulatory 117. Hearne LJ et al. (2019) The Latin Square Task as and subconcussive injury in a human Tau mouse effects of new TSPO ligands in a cellular model a measure of relational reasoning: a replication model results in chronic cognitive dysfunction of tauopathies. Journal of Neuroendocrinology and assessment of reliability. European Journal and disruption of white matter tracts, but not 31: e12796. of Psychological Assessment 36: 296–302. tau pathology. Journal of Neurotrauma 36: 735-755.

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36 QUEENSLAND BRAIN INSTITUTE ANNUAL REPORT 2019 Occupational Health and Safety

QBI’s Occupational Health and Safety team QBI Executive, and liaises closely with the This team was nominated for a UQ drives the implementation of UQ’s Health, central UQ Health, Safety and Wellness Award for Excellence in mental and Safety and Wellness Strategy 2017-2021 (HSW) Division to maintain consistency of physical health, safety and wellness. throughout the Institute and promotes the implementation of the UQ HSW Strategy, Other highlights from the year include the highest practicable standard of occupational and to identify and respond to University- successful opening of a Human Studies health, safety and wellness, while supporting wide HSW priorities. Unit, and arranging mental health seminars and encouraging a positive OHS culture, and and an R U OK Day event, ensuring that the In 2019, the safety team led a project facilitating compliance with legislation and team are supporting the mental as well as comprising researchers and workshop national standards. physical health of staff and students. technicians to design and construct a The team provides advice and support specialised piece of equipment that in health, safety and wellness matters to reduces worker exposure to waste gas.

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