Annual Report 2018 -2019
UOW, ISLHD and the community — Working together for better health Contents
Message from the IHMRI Chair...... 3 Message from the IHMRI Directors...... 4 IHMRI at a glance 2018-2019...... 6 Our research, values and strategic priorities...... 8 Research excellence, innovation and translation...... 10 People and partners...... 12 Stronger community relationships...... 14 Infrastructure and facilities...... 16 Governance...... 18 Income statement and balance sheet...... 20 Funded research 2018...... 22 Grant success...... 23 Publications...... 37
IHMRI acknowledges and pays respects to the traditional owners of country throughout Australia and their continuing connection to land, sea and community.
OUR PARTNERS
Working together for better health
Cover photo: Participants in UniActive's Go Commando for Motor Neurone Disease on 6 April 2019. Photo by Jake Lapham Professor Alan Pettigrew. Photo by Trudy Simpkin.
Message from the IHMRI Chair
Collaboration is a major goal for many organisations around the place their projects within new schemes, and write their applications. world. And with good reason. Working with people from different They also provided vital advice on new eligibility requirements, backgrounds or areas of expertise can result in better ideas and application processes and submission deadlines. I believe this service outcomes. will greatly increase the chances of funding success. The Illawarra Health and Medical Research Institute (IHMRI) provides This financial year was a remarkable time for increased recognition the right environment for collaboration to flourish. As a not-for-profit on the international stage. In November 2018, IHMRI secured charity, we bring together a diverse range of academics, clinicians widespread attention with the opening of its new Electrophysiology and health professionals to work on solutions to diseases such as Facility for Cell Phenotyping and Drug Discovery, which was attended cancer, dementia, diabetes and mental illness. Our vision is to by Australia’s Chief Scientist Dr Alan Finkel AC. I am very excited by improve the health and wellbeing of people living in the Illawarra- the breakthroughs in drug discovery that this facility will uncover. Shoalhaven through research excellence and innovation. The Australian Research Council's 2018 Excellence in Research Relationships are the foundation of IHMRI’s continuing success. Australia report also revealed how IHMRI researchers are making Throughout the year, we worked closely with state government a significant contribution to UOW’s global reputation for research, entities, such as the Office of Health and Medical Research, to with five health and medical disciplines ranking 'well above world report on our results and provide feedback on policy proposals. standard'. IHMRI also plays an influential role in key partnerships with other I would like to acknowledge the contributions of Professor Judy Raper universities and medical research institutes. and Emeritus Professor John Rostas who both retired from the IHMRI This year I was proud to see IHMRI CEO and Executive Director, Board of Directors after many years of service. I would also like to Distinguished Professor David J. Adams, appointed to the Advisory thank IHMRI’s Executive Management Team and operations staff for Committee of the NSW Government’s Cardiovascular Disease their swift and energetic implementation of IHMRI’s Strategic Plan Research Capacity Development Program. I look forward to assisting 2017 – 2021. in efforts to secure more cardiovascular researchers to this region to Now that we are on the cusp of a new decade, I am excited to see take advantage of this significant stream of funding. how IHMRI can shape an expanded partnership with our founding As a dynamic and agile organisation, IHMRI is ready to respond to partners so that our shared research can continue to create lasting Australia’s challenging and competitive environment for health and impact in our region and beyond. medical research funding. IHMRI’s new Research Development Office (RDO) adeptly managed significant changes to the structure of the National Health and Medical Research Council’s grant funding program. RDO staff helped IHMRI researchers based in the University of Wollongong (UOW) Professor Alan Pettigrew and the Illawarra Shoalhaven Local Health District (ISLHD) strategically Chair, IHMRI Board
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 3 Distinguished Professor David J. Adams and Professor Leonard Arnolda. Photo by Paul Grabowksi.
Message from the IHMRI Directors
The passionate and unwavering pursuit of discovery. This is the spirit Our efforts are paying dividends. In 2018, 20 new clinicians of the Illawarra Health and Medical Research Institute (IHMRI). Our joined IHMRI as affiliated researchers. IHMRI is actively working affiliated researchers are a diverse group of academics, clinicians with clinicians in the Illawarra Shoalhaven Local Health District and health professionals. They work together to uncover new insights (ISLHD) to support research project development and source funding into the human body, find better ways to treat disease and illness, opportunities, with almost $200,000 provided to clinicians in IHMRI and improve clinical practice. internal grants. Over the past 12 months we continued to implement initiatives set This year we implemented a new Community Engagement Strategy out in our Strategic Plan 2017-2021. To develop a collaborative and assigned extra resources to develop new outreach and internal culture focused on excellence, we promoted research engagement activities. We are very grateful to our community integrity, and supported equity, diversity and inclusion. We supporters, including The Great Illawarra Walk, the Saving Chloe also sought a deeper understanding of the diverse needs of our Saxby Foundation, the Illawarra Cancer Carers, the Oak Flats researchers. Lioness Club, UniActive and Mr Richard Miller. By improving research performance, we have increased funding We acknowledge Professor Brett Garner for his contribution to IHMRI for infrastructure from the Medical Research Support Program of the as interim Executive Director in 2014. An outstanding researcher NSW Office of Health and Medical Research, with $1,177,848 in neurodegenerative diseases, Professor Garner retired from his received in 2018-2019. academic position at the University of Wollongong (UOW) this year. We wish him all the best in his new endeavours. To further increase the chances of funding success, IHMRI’s new Research Development Office (RDO) implemented a pro- We would like to thank IHMRI’s Board of Directors for their continued active and strategic approach to grant applications and quickly commitment to IHMRI’s growing independence and our partners — identified, promoted and advised on new funding opportunities UOW and ISLHD — for their ongoing support. Finally, we thank our such as the inaugural Dementia Australia Research Foundation, dedicated operations team who help make IHMRI a dynamic, and new funding streams of the National Health and Medical focused and outcome-driven research institute. Research Council. This year we have also been fortunate to secure commercial funding sources for key projects in IHMRI’s new Electrophysiology Facility for Cell Phenotyping and Drug Discovery. The rollout of the Research and Innovation Strategy 2017- Distinguished Professor Professor Leonard Arnolda
2020 continued, with new programs to assist the professional David J. Adams Clinical Director and Deputy Executive Director, development of our researchers, to grow expertise in health CEO and Executive Director, Illawarra Health and Medical Research Institute analytics, and to encourage collaboration between academics Illawarra Health and Medical Clinical Director, Health and Medical Research, and clinicians. Research Institute Illawarra Shoalhaven Local Health District
4 2018-2019 ANNUAL REPORT Our vision
Excellence and innovation in health and medical research, supporting better health services, leading to a healthier Illawarra community
Our purpose
To build a nationally and internationally recognised centre of health and medical research targeting regionally relevant health improvements, better clinical practice and preventative health IHMRI at a glance 2018-2019
Statistics
180 296 531 14 Affiliated researchers PhD candidates and Publications* Clinical trials (commercial and higher degree students investigator initiated studies)
93 $15.9M 45% 23% Externally funded Total funding from Publications Publications research projects external grants, consulting with international with Australian and contracts* collaboration*# collaboration*#
*Based on 2018 data only. #IHMRI Research Fellows only.
ALLOCATION OF MRSP FUNDING
9%
30% 15%
7%
23% 17% $1,17 7, 8 4 8 Medical Research Support Program (MRSP) funding from Clinical research Laboratory Laboratory the NSW Government for and trials operations equipment
research infrastructure Research Research IHMRI grants strategy theme support
6 2018-2019 ANNUAL REPORT Our research 7. 6% We combine the academic insights of scientists with the practical skills of clinicians and health professionals. 20.2% 37.5% The work of our researchers is translational, spanning basic science through to clinical population and public health research.
FUNDED RESEARCH PROJECTS BY CATEGORY 34.6% Basic Clinical medicine Public Health science and science health services
Based on 2018 data only.
Our multidisciplinary researchers Mental health work within and across three broad and the ageing brain research themes. Researchers in this theme examine the mechanisms, causes, prevention and treatment of a wide range of chronic and complex psychiatric illnesses, Diagnostics neurodegenerative diseases and neuro- and therapeutics developmental disorders. Together they Researchers in this theme explore the seek to address the burden of mental fundamental mechanisms of disease. illness and neurodegenerative They use this knowledge to design, diseases in the region. test and evaluate new drugs as well as medical devices. They work together to increase treatment options and quality of life for patients with complex medical conditions. Chronic conditions and lifestyle Researchers in this theme study the links between disease and lifestyle risk factors, such as excess weight, poor diet, high RESEARCHERS BY THEMES blood pressure, drug addictions and physical inactivity. They work together
Diagnostics to find better treatments and and therapeutics prevention strategies to extend healthy ageing. Chronic conditions and lifestyle
Mental health and the ageing brain
Number of 010 20 30 40 50 60 70 80 90 100 researchers
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 7 Our research
Although our affiliated researchers come from different scientific and clinical disciplines, they are united in their commitment to improve the health and wellbeing of people living in the Illawarra-Shoalhaven. Our researchers also aim to have a national and global impact.
Translational research
IHMRI fosters a translational approach to research. The following framework helps direct our researchers to find better ways to treat disease and illness, and implement improvements in health care.
Discover the mechanisms and pathways underlying clinical conditions, especially age-related diseases, chronic conditions and mental illness.
DISCOVER
IMPROVE
Improve the range and effectiveness of clinical treatments, through preventative lifestyle interventions, new drugs and delivery methods, innovative medical devices and implants. DEVELOP
Develop and test new models of health care and population health interventions.
8 2018-2019 ANNUAL REPORT Our values
Our values guide how we behave, how we treat other people and how we achieve success.
SUPPORT
We provide a respectful culture that is open, equal, inclusive and celebrates diversity.
SHARE INSPIRE
We nurture collaboration in We are leaders, innovators collective spaces, exchange and influencers who champion knowledge and engage with research integrity and reward our stakeholders. excellence.
Strategic priorities 2017-2021
STRATEGIC PRIORITY 1 STRATEGIC PRIORITY 2 STRATEGIC PRIORITY 3 Enhance our research excellence, Develop our people and engage Develop stronger community innovation and translation with our partners to improve health relationships to enhance and medical research both locally understanding, foster support and and globally maximise our impact
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 9 STRATEGIC PRIORITY 1: RESEARCH EXCELLENCE
The fight against motor neurone disease
Senior Professor Mark Wilson and Professor Heath Ecroyd. Photo by Alex Pike.
USA Department of Defense funds search for new treatments
When motor neurone disease (MND) Over the next two years the researchers, strikes, the results are devastating, not only “The search for these drug with collaborators at Macquarie University for the people afflicted but their families, and the Queensland Brain Institute, will carers and communities. leads is imperative if we use the funding to perform a rapid flow cytometry screen for identifying novel drug Around 2,000 Australians are living with are to have the capacity leads for MND. the disease, gradually losing the use of their to save individuals from arms and legs, as well as their ability to the debilitating and cruel “We invested several years of work to speak, swallow and breathe. There is no develop a new cell-based assay that effective treatment or cure, and most people afflictions imposed by this provides a unique way to rapidly and die within three to five years of diagnosis horrid disease.” quantitatively examine the effects of large numbers of small drug molecules With in-depth knowledge of proteostasis and Senior Professor Mark Wilson on a process that is strongly implicated cellular stress responses, Senior Professor in disease causation,” explains Senior Mark Wilson and Professor Heath Ecroyd are Professor Mark Wilson. part of the global fight against MND. The USA DoD is a major source of funding for MND research. War veterans in the Once armed with their state-of-the-art rapid Based within the University of Wollongong’s USA, who currently number more than 21 flow cytometry screen, the researchers School of Chemistry and Molecular million, have a higher incidence of MND will be able to discover potential new Bioscience, the duo are gaining an than the general population. treatments for further analysis and clinical international reputation for their expertise, trials — knowledge which one day may with the USA Department of Defense (USA In 2019, the researchers received a help alleviate the plight of sufferers and DoD) supporting their development of a drug Therapeutic Idea Award from the USA their families worldwide. testing trial for MND, which is also known DoD’s Amyotrophic Lateral Sclerosis as amyotrophic lateral sclerosis (ALS). Research Program (ALSRP).
10 2018-2019 ANNUAL REPORT Clearing the air on Distinguished Professor Xu-Feng Huang, Professor Nadia Solowij, Dr Katrina Green and medicinal cannabis Dr Ashleigh Osborne. Photo by Simon Bullard.
IHMRI researchers play key role in NHMRC Centre of Excellence
Although policy makers in Australia are in Funded by the National Health and Medical Co-led by Professor Jenny Martin from the the process of decriminalising cannabis Research Council (NHMRC), the Australian University of Newcastle and Professor for medicinal purposes, scientists are still Centre for Cannabinoid Clinical and Nadia Solowij from the University of debating the therapeutic properties and Research Excellence (ACRE) wants to ensure Wollongong’s (UOW) School of Psychology, long-term safety of the drug. Australians have access to products that are ACRE aims to build capacity in medicinal safe and effective for certain conditions. cannabis research and provide a national response to current challenges. “… there is tremendous opportunity for Australia to Distinguished Professor Xu-Feng Huang and establish world leadership in cautious and appropriately Dr Katrina Green from UOW’s School of Medicine are also part of ACRE, which balanced management of the implementation of medicinal comprises over 20 Chief and Associate cannabinoids into specialist and primary health care Investigators from multi-disciplinary fields settings.” Professor Nadia Solowij from over 10 Australian universities and other research institutions.
Helping people with blood cancer Cancer Council NSW supports research into graft-versus-host disease
What happens when a life-saving treatment causes a life-threatening side effect? “My team aims to uncover new and exciting treatment Graft-versus-host disease (GVHD) is a approaches for blood cancers that prevent GVHD, while debilitating and painful illness that occurs retaining immune responses to cancer and infection.” in around half of patients who receive a donor stem cell transplant to treat blood Dr Debbie Watson cancer. The disease attacks the organs, including the liver, skin and gut. It can In recognition of this growing health Dr Debbie Watson. cause organ damage and failure, and in challenge, the Cancer Council NSW some cases, death. Photo courtesy of awarded Dr Debbie Watson from UOW’s Cancer Council NSW. In 2019, over 6,400 Australians will be School of Chemistry and Molecular diagnosed with lymphoma, and 4,200 Bioscience a three-year project grant to will be diagnosed with leukaemia. More investigate measures to prevent graft-versus- research is urgently required to ensure these host disease (GVHD). people can receive essential transplants without developing GVHD.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 11 Associate Professor Ping Yu, Professor Victoria Traynor, STRATEGIC PRIORITY 2: PEOPLE AND PARTNERS Dr Hui Chen (Rita) Chang, Professor Val Wilson, Nicole Britten, Jessica Bresolin, Dr Jessica Nealon. Photo by Paul Jones.
Improving the detection and treatment of delirium
Training nurses through role-play
Delirium is an acute, reversible, short-term confusion that presents as agitation and “We will use role-play scenarios of a person suffering reduced alertness. Untreated and undetected delirium, with clinical staff undertaking an assessment of delirium leads to falls, longer stays in hospital and sometimes death. Older people the ‘actors’ to detect delirium and implement management undergoing surgery are at a higher risk of strategies to treat delirium. This type of education is not yet experiencing delirium. commonplace in healthcare workplaces and will provide A group of IHMRI researchers from the evidence for the effectiveness of this approach to improve Schools of Nursing, Medicine, and Professor Victoria Traynor Computing and Information Technology delirium care.” at the University of Wollongong (UOW) are striving to improve the care of hospital Grant from the NSW State Government, success of this research, helping with grant patients experiencing post-operative co-led by Professor Valerie Wilson from applications and providing financial support delirium. the Illawarra Shoalhaven Local Health for supplementary research. In 2018, In 2018, Professor Victoria Traynor and District and UOW’s School of Nursing. Professor Victoria Traynor and Dr Jessica Professor Hui Chen Chang from UOW’s The research team, which also includes Nealon received an IHMRI Collaborative Aged Dementia Health Education & Associate Professor Ping Yu, Dr Jessica Research Grant for their project, Research received a grant from the Ramsay Nealon, Jessica Bresolin and Nicole Britten, Postoperative delirium in post-anaesthetic Hospital Research Foundation to implement will work with clinical staff in recovery units care units: Translating knowledge into a delirium education program. at Wollongong, St. George and Bega practice, which helped them implement hospitals to improve delirium care. a survey to understand international In 2019, they were part of a larger team perspectives about delirium care after IHMRI has played a supportive role in the that received a Translational Research operations.
12 2018-2019 ANNUAL REPORT Under the skin Seeking answers for traumatised people
Neuroscientist Dr Natalie Matosin, from the conditions. Now back at IHMRI, she University of Wollongong's (UOW) School aims to develop a framework to identify Dr Natalie Matosin. Photo by Alex Pike. of Chemistry and Molecular Bioscience, is the people who would benefit from early an early-career researcher who is quickly intervention and treatment. developing a reputation for excellence in IHMRI has supported her career trajectory by neurobiology and the genetics of mental providing support at key stages. In 2019, she illnesses including post-traumatic stress received a Dame Bridget Ogilvie Scholarship disorder, depression, bipolar disorder and to assist with an opportunity to enhance her schizophrenia. career profile. She also won an IHMRI Young After completing her PhD at IHMRI in Investigator Award (YIA) for her project, TRIP: 2015, Dr Matosin was awarded a The Trauma and Refugee Intervention Project. prestigious CJ Martin Fellowship from the National Health and Medical Research Council. The Fellowship enabled her to “My research aims to uncover how stress gets under the skin undertake a two-year post-doctoral position by analysing the molecular makeup of biological samples at the Max Planck Institute of Psychiatry like blood or saliva from people living with mental illness, in Germany. During her time overseas she refined her knowledge of the genetic or the brains of those who have now passed but who had and molecular basis of severe psychiatric very stressful lives.” Dr Natalie Matosin
Samantha Wade, Sepehr Talebian, Dr Javad Foroughi, Distinguished Professor Gordon Wallace, Executive Director of ACES, and Dr Kara Vine-Perrow. Photo by Alex Pike.
A new treatment for pancreatic cancer
Researchers collaborate on implantable drug delivery systems
Despite advances in cancer screening, improve the chances of life-saving surgery Electromaterials Science (ACES), and diagnosis and therapy, pancreatic cancer for patients, combining their considerable supervising PhD candidates Samantha remains one of the most deadly forms of expertise in drug development, oncology Wade and Sepehr Talebian on the project. cancer in Australia. It is a highly malignant and smart materials. A Priority-driven Collaborative Cancer Research disease with poor prognosis. The most Research Fellow and project lead, Dr Scheme grant from Cancer Australia/Pancare common treatment remains surgery but Kara Vine-Perrow, from UOW's School Foundation supports the project. for more than 80 per cent of patients this of Chemistry and Molecular Bioscience, surgery is not an option. The partnership between IHMRI and ACES is collaborating with oncologist Clinical helps bring together researchers from diverse A multidisciplinary team of academics Professor Morteza Aghmesheh from disciplines through regular seminars and and clinicians are studying a new drug Wollongong Hospital, Dr Javad Foroughi joint PhD scholarships. delivery system to reduce cancer cells and from the ARC Centre of Excellence for
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 13 Clare Watson, Professor Justin STRATEGIC PRIORITY 3: STRONGER COMMUNITY RELATIONSHIPS Yerbury and Rachelle Balez. Photo by Craig Nealon.
The beauty of science
Science art exhibition raises over $10,000 for MND research
Magnified, a science art exhibition held at held at the TAEM Gallery in UOW’s School to support the next-generation of researchers the University of Wollongong (UOW) in July of the Arts, English and Media who are working towards a better future for 2018, raised over $10,000 for emerging people living with MND. The Opening Night Function was attended researchers studying motor neurone disease by a number of VIPs, including the major Thanks to these scholarships, three emerging (MND). event sponsor Jason Ballerini from Just and talented researchers were able to The exhibition featured a stunning display Better Care, local community sponsors expand their knowledge and networks at the of 55 original images of science, kindly Sharon Bird MP, Paul Scully MP, Ryan Park International Symposium on Motor Neurone donated by researchers at IHMRI, the MP and Stephen Jones MP, as well as Disease in Glasgow in 2018. University of Wollongong (UOW) and BlueScope Steel. “As researchers looking at the human body, we see these Organised by former IHMRI Research Assistant, Clare Watson, and PhD amazing images of cells or proteins through a microscope candidate, Rachelle Balez, Magnified also every day and it’s easy to forget how fascinating they are. helped educate over 300 people who There are so many amazing and creative images that are visited the exhibition about the fascinating research conducted in the Illawarra. The pair locked away in a cupboard or on a hard drive in a lab. We organised Magnified in honour of Professor want to share our work with the community.” Rachelle Balez Justin Yerbury, a renowned and inspirational MND researcher who also lives with the disease himself. representatives from industry sponsors at They have now returned home, ready to Funds were raised via the sale of the framed Leica, Millennium Bioscience, Bluescope share their new insights with colleagues images, as well as reprints. Almost all of Steel and Photomart. and the community. Four researchers were the artworks were sold, with 35 quickly awarded a scholarship in 2019 to attend The money raised funded the Magnified purchased at the Opening Night Function, the Symposium in Perth in December. Justin Yerbury Travel Scholarships, which aim
14 2018-2019 ANNUAL REPORT Front: Dr Benjamin Buckley, Sue Maidman and Professor Marie Ranson. Photo by Mark Newsham.
For President of the ICC, Sue Maidman, the donations to IHMRI are a long- term commitment to the health of future generations. “The research they are doing is going to help our children and grandchildren,” she stated. Such local support is invaluable as Caring for the community competitive government funding does not always cover the high costs of cancer Fundraisers support search for new research. The ICC’s most recent donation supported a project led by Professor Marie cancer treatments Ranson and Associate Professor Michael Kelso from UOW's School of Chemistry and Over the past 10 years, the Illawarra volunteers have direct access to the cancer Molecular Bioscience to develop a novel Cancer Carers (ICC) have donated more researchers. This allows the researchers to drug for pancreatic and breast cancer. than $1 million for cancer research at IHMRI nominate a pressing project and ICC to This research examined the cancer-fighting from funds raised through stalls, raffles and fundraise for that specific project, allowing characteristics of compounds derived from events, including an annual banquet. the donors to know where the donations amiloride, a diuretic drug used for over five are being spent and the researchers to A unique feature of the relationship decades to treat high blood pressure, heart receive support for vital projects. between ICC and IHMRI researchers is the failure, or extra fluid in the body.
Back: Chris Lovatt, Kara Lamond, Emilie Wells, Martin Merrit, Ruth Lovatt. Front: Associate Professor Lezanne Ooi, Chloe Saxby, Nyree Saxby. Photo by Alex Pike.
Marathon walkers step out for research Community support enables research into rare disease
Chris and Ruth Lovatt love supporting causing problems with movement and treatments for VWMD. Her team uses cutting- charities and they love to walk! Since mental functioning. There is currently no edge stem cell and drug testing technology 2008, the couple have organised the cure for VWMD and current treatments only to undertake this meticulous work. annual fundraising hike, The Great Illawarra alleviate the symptoms. Two girls in the In 2018, The Great Illawarra Walk raised Walk. For the past two years they have region, Chloe Saxby and Holly Burns, suffer $100,000 for this research, and in 2019 donated the proceeds to IHMRI research into from this debilitating and painful disease. they raised a further $150,000, with Vanishing White Matter Disease (VWMD) IHMRI neuroscientist Associate Professor over 800 people taking part in the event. for the Saving Chloe Saxby campaign. Lezanne Ooi from UOW's School of Research into rare diseases like VWMD is VWMD is a rare neurodegenerative Chemistry and Molecular Bioscience leads not usually funded by government schemes, condition that affects the nervous system, a research project to discover potential new so this community support is vital to the continuation of the project. “We are testing thousands of drugs in the laboratory to find Due to the overwhelming success of the something that will stabilise and protect Chloe’s cells against 2019 Walk, Chris and Ruth Lovatt will donate the proceeds of the 2020 Walk to further deterioration caused by this genetic disease.” IHMRI research into VWMD for the Saving Associate Professor Lezanne Ooi Chloe Saxby campaign.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 15 Dr Alan Finkel AO and INFRASTRUCTURE AND FACILITIES Distinguished Professor David J. Adams. Photo by Mark Newsham.
Chief Scientist launches new electrophysiology facility
The drug testing SynchroPatch 384PE robot
Australia’s Chief Scientist, Dr Alan Finkel AO, Nanion SynchroPatch 384PE robot. This and physiologists in the Sydney region to visited the Illawarra in November 2018 to high-throughput (HT) automated patch augment and accelerate existing research open IHMRI’s Electrophysiology Facility for clamp system allows researchers to measure projects. Cell Phenotyping and Drug Discovery (E-Phys electrical activity in up to 384 single living “This facility represents a quantum leap in core). cells at a time, and their responses to productivity for biosciences in this country, different drugs. This speeds up the process Electrophysiology is the branch of which will potentially give the Australian of cell analysis and significantly reduces neuroscience that explores the electrical pharmaceutical industry a competitive global laboratory times for researchers. activity of living neurons and investigates the edge,” said Distinguished Professor David molecular and cellular processes that govern The E-Phys core, which is available for hire, J. Adams, IHMRI’s Executive Director and their signalling. will also help bring together biophysicists, CEO. cell biologists, chemists, pharmacologists The E-Phys core houses the state-of-the-art The SyncroPatch 384PE was funded by an Australian Research Council Linkage, Infrastructure, Equipment and Facilities “IHMRI’s new facility will significantly improve the rate Grant awarded in 2017 to a partnership of drug discovery for conditions such as chronic pain, of scientists from IHMRI, the University of epilepsy, dementia and irregular heart beat.” Sydney, the University of New South Wales and the Victor Chang Cardiac Research Dr Alan Finkel AO, Australia’s Chief Scientist Institute.
16 2018-2019 ANNUAL REPORT Associate Professor Lezanne Ooi and Professor Chennupati Jagadish AC. Photo by Paul Jones.
Innovative dementia research
Collaborative project uses IHMRI stem cell expertise
Alzheimer’s disease affects nearly half a are helping to find solutions to this growing organoids and healthy organoids to improve million Australians and is the second leading health crisis. understanding of the disease. cause of death in the country. The pair are part of a research project, led "In a petri dish, we are able to model the Working within IHMRI’s state-of-the-art by Professor Chennupati Jagadish AC from function of a healthy brain and the function laboratories, Associate Professor Mirella the Australian National University, which of a brain with Alzheimer's disease. Dottori and Associate Professor Lezanne Ooi is comparing Alzheimer’s affected brain We then use Artificial Intelligence based computational analysis to compare the differences," said Associate Professor “By using platforms at IHMRI, like the new electrophysiology Lezanne Ooi. facility and the SyncroPatch robot, we will be able to measure The project, funded by the Dementia Australia Research Foundation, also the functionality of neurons and their networks to determine the features researchers from the University of difference between cells from Alzheimer’s and non-Alzheimer’s Melbourne, Monash University and the donors.” Associate Professor Mirella Dottori University of California, San Diego, USA.
Do you comfort eat when you are blue? The Mood, Food and Biomarkers Study
IHMRI’s well equipped Clinical Research The team, Dr Theresa Larkin, Professor and Trials Unit (CRTU) offers facilities and Chao Deng, Dr Susan Thomas, and PhD services for a range of clinical research candidate Jessica Mills, measured appetite studies and commercial clinical trials. hormones including grehlin and leptin in the Our region’s demographic and economic trial participants. Early findings from this trial diversity, and incidence of chronic disease, suggest a link between excessive eating and Dr Susan Thomas, Jessica Mills and Professor Chao Deng. Photo by Trudy Simpkin. also makes it an ideal place for population an insensitivity to hormonal signals. health studies and clinical trials. The researchers plan to conduct a larger A research team from the University of study in the Illawarra, which will follow Understanding this relationship is important Wollongong’s (UOW) School of Medicine participants over a period of 12 months. The for preventing chronic disease, as gaining recently used IHMRI’s CRTU for a study aim of this trial is to determine which comes weight puts people at risk of other health examining the relationship between comfort first – do hormones cause the comfort eating, problems later in life, including heart disease eating and depression. or does comfort eating affect the hormones? and metabolic syndrome.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 17 Governance
The IHMRI Board convened six times during the 2018-2019 financial year to conduct usual business. The Board comprises three independent Directors, three Directors nominated by each of its key stakeholders, the University of Wollongong (UOW) and the Illawarra Shoalhaven Local Health District (ISLHD), and the Executive Director.
Board of Directors
The following were Directors during whole or part of the financial year: Professor Alan Pettigrew, BSc, PhD, FAICD (Chair) — Consultant and adviser on higher education and research Emeritus Professor John Rostas, BSc (Hons), PhD (Deputy Chair) — Faculty of Health and Medicine, University of Newcastle Mr Tim Berry, BMath & Fin — Non-Executive Director, Tibra Capital Professor Simon Gandevia, FAA, FAHMS, FRACP, FPhysiol, DSc, MD, PhD — Deputy Director and Foundation Scientist, Neuroscience Research Australia Professor Paul Wellings CBE, BSc, MSc, PhD, DSc (Hon), FRSN, FRSA, FAICD — Vice-Chancellor and Principal, UOW Professor Judy Raper, BE (Hons), PhD, FIEAust, FAATSE, FAICD — Deputy Vice-Chancellor (Research and Innovation), UOW Professor Jennifer L Martin AC, BPharm, MPharm, DPhil (Oxon) — Deputy Vice-Chancellor (Research and Innovation), UOW Mr Damien Israel, BBus, MAcc, FCPA — Chief Finance Officer, UOW Ms Margot Mains, LLB, RGON, DipNG — Chief Executive, ISLHD Dr Michael Davis, MBBS, FANZCA, FJFICM — Critical Care Co-Director and Director Intensive Care, ISLHD Dr Mark Bassett, MB ChB, MD, GraDipMgt, MHA, FRACP — Acting Executive Director, Medical Services and Clinical Governance, ISLHD Associate Professor Bruce Ashford, BDSc (Hons), PhD, MBBS, FRACS — Consultant Surgeon (Head and Neck), ISLHD Distinguished Professor David J. Adams, BSc (Hons), PhD — Executive Director, IHMRI.
IHMRI Patron
Dame Bridget Ogilvie AC, DBE, ScD, FRS, FAA—Australian and British scientist
Executive Team Dame Bridget Ogilvie. During the reporting period, IHMRI’s executive management team comprised: Photo by Mark Newsham CEO and Executive Director—Distinguished Professor David J. Adams, BSc (Hons), PhD Clinical Director and Deputy Executive Director—Professor Leonard Arnolda, MBBS (Hons), FRACP, PhD Chief Operating Officer—Ms Kara Lamond, BA, BURP, MBA, GradCertLaw, MAICD
Research Integrity Advisors
IHMRI works with UOW's Research Integrity Office to promote research integrity and help ensure compliance with the Australian Code for the Responsible Conduct of Research. Associate Professor Martina Sanderson-Smith represents IHMRI as a UOW Research Integrity Advisor (RIA). Other IHMRI researchers who act as RIAs are Professor Chao Deng for Animal Research, Dr Jonathan Shemmell for Medicine (Human Research), and Dr Jenny Sim for Nursing. Associate Professor Martina Sanderson- Smith. Photo by Trudy Simpkin
18 2018-2019 ANNUAL REPORT Scientific Advisory Committee
IHMRI Directors appointed a Scientific Advisory Committee (SAC) for 2017-2019. The SAC provides advice on IHMRI’s research priorities and research strengths, as well as guidance on funding opportunities. The SAC also participates in reviews of research initiatives and provides a broad perspective of national and international trends in health and medical research. The SAC consists of eight members, including IHMRI’s Executive Director and Clinical Director, and external members who serve for an initial term of three years. Drawn from a range of external Australasian institutions and universities, the external committee members are highly successful and experienced international researchers. All of the members are new, apart from Professor Christos Pantelis who served on the previous SAC from 2014-2016.
Professor Robin Anderson Professor Perry Bartlett FAA Head, Translational Breast Cancer Program, Director, Queensland Brain Institute, Olivia Newtown John Cancer Research Institute University of Queensland
Professor Mark Cooper AO Professor David Craik FAA Head, Department of Diabetes, Institute for Molecular Bioscience, Monash University University of Queensland
Professor Christos Pantelis Professor Melissa Wake Scientific Director, Melbourne Neuropsychiatry Centre, Cure Kids Professor of Child Health Research, University of Melbourne Department of Paediatrics, and the Liggins Institute, University of Auckland
Theme Leaders
In early 2017 IHMRI appointed new Theme Leaders for 2017-2019 to co-direct each research theme. The Theme Leaders for 2017-2019 include original theme leader Associate Professor Spiros Miyakis, who will provide continuity to programs, strategies and activities established over the past two years.
MENTAL HEALTH AND THE AGEING BRAIN Clinical Scientific Distinguished Professor Xu-Feng Huang Professor Heath Ecroyd School of Medicine, UOW Proteostasis and Disease Research Centre, Director, UOW Centre for Translational Neuroscience School of Chemistry and Molecular Bioscience, UOW
CHRONIC CONDITIONS AND LIFESTYLE Clinical Scientific Professor Ian Wright Professor Barbara Meyer Professor of Paediatrics, School of Medicine, UOW ISLHD Director, Lipid Research Centre Paediatrics and Child Health Research, School of Medicine, UOW
DIAGNOSTICS AND THERAPEUTICS Clinical Scientific Associate Professor Spiros Miyakis Associate Professor Martina Sanderson-Smith Acting Director of Infectious Diseases, School of Chemistry and Molecular Bioscience, UOW Wollongong Hospital Staff Specialist in Medicine and Infectious Diseases, ISLHD School of Medicine, UOW
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 19 Income statement
FOR THE YEAR ENDED 30 JUNE 2019
2019
$’000
INCOME
Service Agreements 6,323
Government Grants 1,178
Donations and Fundraising 318
Other Income 351
TOTAL INCOME 8,170
EXPENDITURE
Employee Related 3,064
Building Lease 2,539
Research Development 438
Research Infrastructure 223
Other Operating Expenses 1,015
TOTAL EXPENDITURE 7,279
OPERATING RESULT 891
Balance sheet
AS AT 30 JUNE 2019
2019
$’000
Current Assets 4,529
TOTAL ASSETS 4,529
Current Liabilities 894
TOTAL LIABILITIES 894
NET ASSETS 3,635
TOTAL EQUITY 3,635
*Unaudited at time of publication
20 2018-2019 ANNUAL REPORT Working together for better health Funded research 2018
NUMBER OF EXTERNALLY FUNDED RESEARCH PROJECTS BY TYPE OF GRANT IHMRI researchers are involved in a 40 35 total of 93 externally 30 25 funded research 20 15 projects. Twenty 10 Number of grants 5 six per cent of 0 Types of grants these projects were
National Health and Medical Research Council Category 2 and 3 grants initiated in 2018. Other Australian Competitive Grant Register grants International
EXTERNAL GRANT FUNDING BY TYPE OF GRANT In 2018, IHMRI researchers received $5.0M $4.5M a total of $12.2M in $4.0M $3.5M grant funding. $3.0M $2.5M $2.0M Amount $1.5M $1.0M $0.5M $0 Types of grants
National Health and Medical Research Council Category 2 and 3 grants Other Australian Competitive Grant Register grants International
NUMBER OF PROJECTS BY RESEARCH CATEGORY
9 6
39
34
Basic research Clinical medicine and science Health Services Public Health
22 2018-2019 ANNUAL REPORT Grant success 2018
Where there is more than one researcher, the Chief Investigator is in bold text and IHMRI affiliated researchers are marked with an asterisk.
Australian Competitive Grant Schemes
National Health and Medical Research Council Project Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Antibiotic resistance: combining microscopy, Dr Andrew Robinson* $588,098 microfluidics and genomics to target bacterial Dr Harshad Ghodke* DNA repair pathways Clinical Professor Spiros Miyakis* Distinguished Professor Antoine van Oijen*
Small molecule inhibitors of glutathione Professor Jonathan Baell $737,521 transferase omega 1-1 (GSTO101) for the (Monash University) treatment of inflammatory disease Associate Professor Aaron Oakley* ($60,000)
Effect of exposure to fluoridated water in Professor Loc Do $828,756 early childhood on child psychological and (University of Adelaide) intellectual development Professor Alison Jones* ($0)
The First 1,000 Days: in utero and early life Professor Jodie Dodd $2,426,050 exposures and their contribution to child obesity (University of Adelaide) Dr Danielle Schoenaker* ($0)
The relationship between maternal health and Dr Yogavijayan Kandasamy $1,552,842 infant development and function (University of Newcastle) Professor Ian Wright* ($0)
Equipment Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Rat activity wheel and living chamber system Professor Chao Deng* $10,303 Associate Professor Jeremy Crook* Distinguished Professor Xu-Feng Huang* Dr Katrina Green* Dr Mei Han* Dr Jiamei Lian* Associate Professor Kelly Newell*
GoBlot machines and Leica Objective Associate Professor Lezanne Ooi* $13,405 Professor Chao Deng* Associate Professor Mirella Dottori* Professor Heath Ecroyd* Distinguished Professor Xu-Feng Huang* Professor Marie Ranson* Associate Professor Ronald Sluyter* Senior Professor Mark Wilson* Dr Kara Vine-Perrow* Professor Ian Wright* Professor Justin Yerbury*
DELL PowerEdge R440 Server Professor Nadia Solowij* $10,722 Dr Mark Schira
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 23 National Health and Medical Research Council Centres of Research Excellence
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Australian Centre for Cannabinoid Clinical and Professor Jennifer Martin $2,498,470 Research Excellence (ACRE): Quality and safety (University of Newcastle) in the implementation of medicinal cannabis use Professor Nadia Solowij* ($108,656) in the community Distinguished Professor Xu-Feng Huang* Professor Kathleen Eager
Australian Research Council Discovery Projects
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Pluses and minuses of lipid mass spectrometry Professor Stephen Blanksby $655,000 (Queensland University of Technology) Associate Professor Todd Mitchell* ($327,500)
Strengthening food systems governance at the Dr Belinda Reeve $524,298 local level (University of Sydney) Professor Karen Charlton* ($106,390)
Information sampling in superior face identifiers Dr David White $534,573 (University of NSW) Dr Sebastien Miellet* ($30,000)
Discovery Indigenous Projects
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
A place-based model for Aboriginal community- Professor Kathleen Clapham $498,000 led solutions Professor Valerie Harwood (University of Sydney) Professor Helen Hasan Associate Professor Peter Kelly* Marlene Thompson Associate Professor Kate Senior
24 2018-2019 ANNUAL REPORT Australian Research Council LIEF (Linkage Infrastructure, Equipment and Facilities)
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
A comprehensive correlative cryo microscopy Professor Julie Cairney $540,000 laboratory (University of Sydney) Senior Professor Mark Wilson* ($0)
X-ray facility for protein crystallography Professor Paul Curmi $407,609 (University of NSW) Distinguished Professor Nicholas Dixon* ($0) Associate Professor Aaron Oakely*
Volumetric imaging facility: observing the cell in Distinguished Professor Dayong Jin $1,480,000 its native environment (University Technology Sydney) Distinguished Professor Xu-Feng Huang* ($0) Distinguished Professor Antoine van Oijen*
High-throughput portable and wearable device Distinguished Professor Dayong Jin $407,609 fabrication facility (University Technology Sydney) Distinguished Professor Antoine van Oijen* ($0)
Ultrafast magic angle spinning solid-state NMR Professor Gottfried Otting $178,839 capability (Australian National University) Distinguished Professor Nicholas Dixon* ($0) Professor Heath Ecroyd*
Linkage Projects
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Developing next generation mass spectrometry Dr Berwyck Poad $293,985 imaging with isomer resolution (Queensland University Of Technology) Associate Professor Todd Mitchell* ($0)
Special Research Initiatives
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Stem Cells Australia Professor Melissa Little $3,000,000 (Murdoch Children’s Research Institute) Associate Professor Mirella Dottori* ($0)
Australian Government Department of Health Public Health and Chronic Disease Grant Program
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
The Advance Project: Initiating palliative care Professor Josephine Clayton $2,000,000 and advance care planning through training and (University of Sydney) resources for primary and chronic/complex care Professor Elizabeth Halcomb* ($4,000) clinicians
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 25 Cancer Australia/Pancare Foundation Priority-driven Collaborative Cancer Research Scheme
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Implantable drug-eluting device: localised drug Dr Kara Vine-Perrow* $594,920 delivery for non-resectable pancreatic cancer Clinical Professor Morteza Aghmesheh*
Motor Neurone Disease Research Institute of Australia Grants-in-Aid
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Rapid screening of small molecule libraries to Senior Professor Mark Wilson* $100,000 identify new drug leads to treat Motor Neurone Professor Heath Ecroyd* Disease Professor Justin Yerbury*
Is UBA1 a therapeutic target in ALS? Professor Justin Yerbury* $100,000 Associate Professor Lezanne Ooi* Dr Kara Vine-Perrow*
MS Research Australia Incubator Grant
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Developing methodological translation framework Dr Yasmine Probst* $25,000 for assessing dietary intakes for clinical studies Steve Simpson
Other Grant Schemes Arthritis Australia Grants-in-Aid
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Novel uPA inhibitors for the treatment of RA Dr Benjamin Buckley* $15,000 Professor Marie Ranson*
Australian Academy of Technological Sciences and Engineering (ATSE) Global Connections Fund
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
A bedside molecular imaging tool for breast Dr Yujin Qi $7,000 cancer screening
26 2018-2019 ANNUAL REPORT Australian Nuclear Science and Technology Organisation (ANSTO) Australian Synchrotron Access Program
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Characterisation and stability studies of potential Dr Carolyn Dillon $1,570 arsenic anti-cancer agents
Refining synchrotron microbeam radiation Dr Moeava Tehei* $1,570 therapy techniques in vivo Professor Michael Lerch* Dr Stephanie Corde Tehei*
Australian Synchrotron Research Program Imaging and Medical Beamline
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Fibre optic dosimetry for microbeam radiation Dr Enbang Li* $1,570 therapy Dr Jeremy Davis*
Enhancing synchrotron microbeam radiation Dr Stephanie Corde Tehei* $1,570 therapy in vivo with high-Z nanoparticles Professor Michael Lerch* Dr Moeava Tehei*
California Walnut Commission Research Grant
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Strengthening the evidence base for including Dr Yasmine Probst* $52,556 walnuts in healthy dietary patterns: implications Dr Elizabeth Neale* for dietary advice in clinical practice Senior Professor Linda Tapsell AM*
Cancer Council NSW Project Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Immune Cell Depletion and P2X7 Receptor Dr Debbie Watson $450,000 Blockade to Prevent Graft-versus-host Disease in Blood Cancer Treatment
The Creswick Foundation Fellowship
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Towards the development of an intervention for Amy Bird $15,445 children of parents with Borderline Personality Dr Judy Pickard* Disorder (BPD): PCIT-ME
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 27 Dementia Australia Research Foundation Yulgilbar Foundation Grant
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Use of brain organoids and artificial intelligence Professor Chennupati Jagadish AC $500,000 for understanding Dementia (Australian National University) Associate Professor Mirella Dottori* ($98,736) Associate Professor Lezanne Ooi*
Deutscher Akademischer Austausch Dienst (DAAD) Australia Germany Joint Cooperation Scheme
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Inflammatory Pain - Control of Immune Cell Distinguished Professor David J. Adams* $20,800 Nicotinic Receptor Signaling by Conotoxins? Dr Han-Shen Tae* Mechanisms and Screening Platforms
At the heart of positive psychology: heart-rate Dr Mark Allen $10,000 variability and subjective wellbeing Dr Stewart Vella*
Can urban greening help eliminate child health Associate Professor Xiaoqi Feng* $25,000 inequality? Enhancing the quality of evidence H. M. Mehbub Anwar with multilevel longitudinal analyses in Australia Professor Thomas Astell-Burt* and Germany
What can new developments in X-Tream Professor Michael Lerch* $14,800 Dosimetry teach us for the utilization of dose Dr Jeremy Davis* enhancement in experimental microbeam Elette Engels* radiotherapy and clinical radiotherapy?
Determination of the binding sites and mode of Dr Karen Luna Ramirez $14,000 action of non-classical a-conotoxins
Harvard University Center on the Developing Child
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Learning Through Play - Early Start Discovery Ananthalakshmi (Anita) Kumar $10,000 Space Pilot Project Senior Professor Anthony Okely*
28 2018-2019 ANNUAL REPORT MTP Connect Project Fund Program
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Biopen: Advanced Limb Reconstruction Professor Peter Choong (University of $1,185,801 Programme Melbourne) Distinguished Professor Gordon Wallace* ($397,409)
The Bioprint Facility for Translational Science and Distinguished Professor Gordon Wallace* $400,000 Medicine in the MTP Sector Professor Peter Choong (University of Melbourne) Professor Simon Moulton (Swinburne University of Technology)
NSW Health Translational Research Grants Scheme
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Evaluating two healthy eating and active living Christine May $961,639 support program for parents of 2-6 year old (Murrumbidgee Local Health District) children - Time2bHealthy (online) and Healthy Senior Professor Anthony Okely* ($314,369) Habits (telephone-based) Professor Simon Eckermann Dr Rachel Jones
Alcohol and Other Drugs (AOD) Early Intervention Innovation Fund
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
A randomised controlled trial of a continuing Gerard Byrne $928,244 care telephone intervention following residential (The Salvation Army (NSW) Property Trust) substance abuse treatment Professor Frank Deane* ($185,259) Associate Professor Peter Kelly*
Routine outcome monitoring (ROM) plus Ryan McGlaughlin $361,622 feedback in SMART Recovery Australia: a (SMART Recovery) feasibility study examining SMART ROM Dr Alison Beck (University of Newcastle) Professor Frank Deane* ($79,669) Associate Professor Peter Kelly*
NSW Health, Office for Health and Medical Research NSW Medical Devices Fund
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Development of the iFix system to treat corneal Professor Gerard Sutton $1,150,000 diseases and injuries (Vision Eye Institute Australia) Distinguished Professor Gordon Wallace* ($0)
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 29 Ramsay Hospital Research Foundation Project Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Evaluating the Implementation of a Delirium Professor Victoria Traynor* $77,000 Education Intervention using Clinical Simulation Dr Hui Chen Chang* in a Private Healthcare Setting Professor Peter Smerdely (University of NSW) Amy Montgomery*
Rebecca Cooper Foundation Project Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
The United Colours of Cannabis: A novel Dr Katrina Green $100,000 approach to treating the cognitive symptoms of schizophrenia
In search of non-addictive analgesics: peripheral Dr Jeffrey McArthur $100,000 calcium channel targets
University of Wollongong, Faculty of Science, Medicine and Health Researchers not affiliated with IHMRI are italicised. Research Partnership Grants
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Characterisation of the effects of β-glucan Distinguished Professor Xu-Feng Huang $19,000 on neuroendocrine, microbiome and Partner: Xuzhou Medical University immunomodulation
30 2018-2019 ANNUAL REPORT University of Wollongong, Faculty of Science, Medicine and Health Researchers not affiliated with IHMRI are italicised. Small Project Grants – Health and Medical Collaborative Scheme
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Mood, food and biomarkers: Longitudinal follow Dr Susan Thomas $16,000 up study of factors predicting weight gain and Dr Theresa Larkin chronic disease risk in major depressive disorder Professor Karen Charlton Professor Chao Deng
From lab bench to clinic room: calcium isotopes Associate Professor Anthony Dosseto $19,000 as a non-invasive tool for diagnosis Marc Brown
Understanding cardiovascular risk amongst Professor Elizabeth Halcomb $15,000 middle aged Australians Professor Karen Charlton Dr Rebekkah Middleton
Are all e-cigarette fluids created equal? Professor Alison Jones $19,000 Analytical comparison of the content of e-fluids Dr Celine Kelso currently Dr Jody Moller
Identification of the factors that influence prostate Associate Professor Kylie Mansfield $5,700 cancer treatment Dr Tim Skyring Associate Professor Judy Mullan
Acute effect of fruit anthocyanins on Professor Karen Charlton $16,000 postprandial endothelial function Dr Monique Francois Dr Katrina Green Professor Ian Wright Dr Yasmine Probst Associate Professor Steven Roodenrys
Small Project Grants – Target Stream
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Preventing cardiovascular disease in type 2 Dr Monique Francois $19,000 diabetes; when is the right time to move?
Linking lipid dyshomeostasis in major depression Associate Professor Kelly Newell $16,000 to glutamatergic pathology and neurogenesis Dr Jessica Nealon deficits
Understanding the Molecular Mechanisms of Dr Gökhan Tolun $19,000 Single-strand Annealing Homologous DNA Recombination, by cryo-EM
Promoting science and health to Australian Associate Professor Kathryn Weston $10,000 women: an historical exploration of the promotion of vaccination in women's magazines
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 31 University of Wollongong, Faculty of Science, Medicine and Health Researchers not affiliated with IHMRI are italicised. Small Project Grants – Advancement Stream
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
Examining the anti-depressant drug potential Dr Katrina Green $18,000 of compounds from the cannabis plant: Distinguished Professor Xu-Feng Huang Improving the old and discovering the new.
Timely resolution: an analysis of lipid Associate Professor Todd Mitchell $13,898 mediated inflammation following exercise Dr John Sampson induced muscle damage
SYMBIOTiC Study – SYMptom, microBIOme Dr Anita Stefoska-Needham $16,000 and dieT in Chronic Kidney Disease Professor Karen Charlton
Small Project Grants – Continuity Stream
PROJECT TITLE RESEARCHER(S) TOTAL GRANT AWARDED
A multi-generational study of risk and Associate Professor Sibylle Schwab $19,000 resilience to mental illness in traumatized people
Research Equipment Grants and Small Equipment Grants
EQUIPMENT RESEARCHER(S) TOTAL GRANT AWARDED
Freeze Dryer Associate Professor Michael Kelso $38,640 Dr Chris Richardson Senior Professor Stephen Pyne Professor Paul Keller Associate Professor Danielle Skropeta Dr Carolyn Dillon Distinguished Professor Nicholas Dixon Dr Chris Hyland Dr Ashraf Aboelela Dr Ardeshir Rineh Dr Ramesh Ailuri Dr Vitor Sencadas Gomes da Silva Sencadas
Multimode microplate reader with advanced Associate Professor Martina Sanderson-Smith $75,000 LVF Monochromator and accessory bundle Distinguished Professor Xu-Feng Huang Senior Professor Mark Wilson Associate Professor Ronald Sluyter Associate Professor Aaron Oakley Dr Carolyn Dillon Dr Jacob Lewis Dr Kara Vine-Perrow Professor Heath Ecroyd
32 2018-2019 ANNUAL REPORT University of Wollongong, Faculty of Science, Medicine and Health Researchers not affiliated with IHMRI are italicised. Research Equipment Grants and Small Equipment Grants
EQUIPMENT RESEARCHER(S) TOTAL GRANT AWARDED
'Andor iXon 897, Stradus 405-100 laser, Dr Harshad Ghodke $51,289 Filter and Filter set Dr Bishnu Paudel Dr Jacob Lewis Lisanne Spenkelink Professor Heath Ecroyd Distinguished Professor Antoine van Oijen Dr Amy McGrath
UNICORN 7 Workstation license (3x) Distinguished Professor Nicholas Dixon $16,754 Dr Gökhan Tolun Dr Slobodan Jergic Dr Jacob Lewis Lisanne Spenkelink Dr Amy McGrath
Integrated CO2 incubator-shaker Senior Professor Mark Wilson $16,107 Associate Professor Lezanne Ooi Professor Heath Ecroyd Professor Justin Yerbury Distinguished Professor Xu-Feng Huang Associate Professor Ronald Sluyter Distinguished Professor David Adams Professor Brett Garner Professor Marie Ranson
Protein Detection Equipment Associate Professor Kelly Newell $4,841 Dr Katrina Green Dr Jessica Nealon
PCB control board for mass spectrometer Dr Celine Kelso $14,167 Senior Professor Stephen Pyne Professor Paul Keller Associate Professor Danielle Skropeta Dr Chris Hyland
X-ray generator anode refurbishment Associate Professor Mike Kelso $13,734 Associate Professor Aaron Oakley
Terason u3300 Laptop Premium Ultrasound Dr Monique Francois $20,000 Professor Karen Charlton Professor Isabel Ferreira Senior Professor Julie Steele Dr Theresa Larkin
Components for single-molecule microscope Dr Andrew Robinson $23,383 Dr Bishnu Paudel Distinguished Professor Antoine van Oijen
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 33 University of Wollongong, Faculty of Science, Medicine and Health Researchers not affiliated with IHMRI are italicised. Research Equipment Grants and Small Equipment Grants
EQUIPMENT RESEARCHER(S) TOTAL GRANT AWARDED
UV-1900 UV Spectrophotometer (includes Senior Professor Sharon Robinson $8,000 UV Probe) 230V, CE model Professor Kristine French Associate Professor Laurie Chisholm Professor Dianne Jolley Dr Melinda Waterman Associate Professor Phil Byrne Dr Katarina Mikac Professor Andy Davis
2 x Age simulation suit GERT (simulation of Professor Victoria Traynor $6,678 vision, hearing, motion) Professor Valerie Wilson Dr Hui Chen Chang Dr Susan McInnes Lorraine Fields Maria Mackay Carley Jans
Internal grants 2018 IHMRI Clinical Translational Grant Scheme The IHMRI Clinical Translation Grant Scheme encourages academic and health professional/clinician researchers to co-lead a research project to address regional and medically relevant health issues. Thereby developing the research practice of this partnership, promoting translational research projects and strengthening the ability of a research team to win collaborative research grants in the future. These grants are worth up to $25,000 each.
PROJECT TITLE CLINICAL CHIEF INVESTIGATOR ACADEMIC CHIEF INVESTIGATOR
Circulating tumour nucleic acid as a biomarker in Dr Daniel Brungs Dr Kara Vine-Perrow resectable gastroesophageal cancer
Assessment and management of distress from Dr Greg Barclay Professor Frank Deane breathlessness for patients in palliative care: Dr Esther Davis Benchmarking with clinical practice guidelines
From lab bench to clinic room: calcium isotopes as a Dr Kelly Lambert Associate Professor Anthony Dossetto non-invasive tool for the management of chronic kidney disease
Pilot trial: Can a mobile health coaching program Clinical Associate Professor Associate Professor Ping Yu improve fitness for surgery in patients with obesity? Natalie Smith
Antimicrobial Resistance Global Challenges: the Dr Simeon Crawford Distinguished Professor Antoine Van evolving threat and impact to the Illawarra Shoalhaven Oijen population – a service utilisation perspective
Postoperative delirium in post anaesthetic care units: Nicole Britten Dr Jessica Nealon Translating knowledge into practice Professor Victoria Traynor
34 2018-2019 ANNUAL REPORT IHMRI Young Investigator Awards The Young Investigator Awards encourage early career clinician, health professional or academic researchers (ECR) to develop their skills, expertise and research track records, which will ultimately generate research data to enable the ECR to apply for a future competitive grant as a CI. These grants are worth up to $10,000 each.
PROJECT TITLE RESEARCHER
Novel leads for neuropathic pain: establishing a high-throughput screen for ASIC3 inhibitors Dr Benjamin Buckley
Patient-driven research: investigating possible relationships between the clinical presentation Dr Martin Engel and brain organoid development from the same schizophrenia patients
Combining Exercise and Hydrotherapy to Harness the Glycaemic and Vascular Benefits of Dr Monique Francois Exercise for Obese and Type 2 Diabetes Individuals
TRIP: The Trauma and Refugee Intervention Project Dr Natalie Matosin
Near Miss Grants
IHMRI awards this funding to researchers with high-scoring NHMRC and ARC grant applications, who closely miss receiving funding. These grants are worth up to $10,000 each.
Australian Research Council
PROJECT TITLE INVESTIGATORS
Creating sensory neurons in the culture dish using human stem cells Associate Professor Mirella Dottori
Health Analytics Initiative Grant
IHMRI offered this grant in alignment with our Research and Innovation Strategy 2017-2020, to support and increase health analytics capability. This funding will assist in the strategic direction of the investigator’s own research and the preparation of data to support future external grant applications.
PROJECT TITLE INVESTIGATORS
Research programme ‘The Impact of Practice Changes on Emergency Services at Wollongong Associate Professor Ping Yu Hospital Informed by Health Data Analytics’ Funding for: Project 1: Evaluating the implementation of the pre-hospital phlebotomy practice in an Australian teaching hospital Project 2: The impact of troponin testing on patient journey in the Wollongong Hospital.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 35 Awards and scholarships 2019 Miller Family Bridgewater IHMRI Dementia Honours Scholarship
The aim of these scholarships is to provide prospective Honours students with an opportunity to develop skills and training in dementia research in the Illawarra region, and encourage these students to pursue higher degree research into the diagnosis, cause, treatment and improved care for people suffering from dementia. IHMRI awards five scholarships annually, worth $3000 each.
STUDENT/HONOURS DEGREE PROJECT TITLE SUPERVISOR(S)
Lauren Rice Developing single molecule techniques to Professor Heath Ecroyd Bachelor of Science monitor alpha syncline elongation and its Distinguished Professor Antoine van Oijen inhibition by small heat shock proteins
Alec Becvarovski Cannabidiol (CBD) in the prevention of Distinguished Professor Xu-Feng Huang Bachelor of Pre-Medicine, neurotoxicity and oxidative stress mediated Science and Health by Dopamine-2 receptor hyperactivity
Kristian Claesson Using single molecule techniques to study Professor Heath Ecroyd Bachelor of Medical Biotechnology how chaperone proteins interact with Distinguished Professor Antoine van Oijen aggregation-prone proteins
Dame Bridget Ogilvie Awards
Dame Bridget Ogilvie Citation Award The recipient is an early-mid career woman researcher with the highest percentage of highly cited publications in the last five years. One grant is awarded annually totalling $3,000.
The recipient for 2019 was Dr Katrina Green.
Dame Bridget Ogilvie Clinical Excellence Award Recognises clinical excellence of an early-mid career woman researcher through a demonstrably significant contribution in their respective field of health or health care. One grant is awarded annually totalling $3,000.
The recipient for 2019 was Dr Esther Davis.
Dame Bridget Ogilvie Scholarships Career Advancement Scholarships provide funding to support researchers at any stage of their career to assist financially with an opportunity to enhance their career profile. Two scholarships are awarded annually, worth $1,500 each.
The recipients for 2019 were Dr Natalie Matosin and Dr Monique Francois.
36 2018-2019 ANNUAL REPORT Publications The following health and medical research book chapters, conference proceedings and publications in peer-reviewed journals were published by IHMRI affiliated researchers in the 2018 calendar year. IHMRI researchers are highlighted in bold.
Mental health Bonomo, Y., Souza, J., Jackson, A., Crippa, J. & Solowij, N. (2018). Clinical issues in cannabis use. British Journal of Clinical Pharmacology, 84 and the ageing brain (11), 2495-2498.
Abu-Bonsrah, K., Zhang, D., Bjorksten, A. R., Dottori, M. & Newgreen, D. F. Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A., Ooi, L. & Heeren, (2018). Generation of Adrenal Chromaffin-like Cells from Human Pluripotent R. M. A. (2018). Identification and High-Resolution Imaging of alpha- Stem Cells. Stem Cell Reports, 10 (1), 134-150. Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 29 (8), Allen, M. S., Vella, S. A., Swann, C. & Laborde, S. (2018). Personality 1571-1581. and the subjective experience of body mass in Australian adults. Journal of Research in Personality, 72 73-79. Burnett, C. M., Allen, M. S. & Vella, S. A. (2018). Personality and sedentary behaviour in Australian adults. International Journal of Sport and Exercise Alqarni, A., Mcintyre, K. J., Brown, S. H. J., Meyer, B. J. & Mitchell, T. W. Psychology, 16 (3), 215-220. (2018). A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index. Lipids, 53 (10), 1005-1015. Calvert, F. L., Deane, F. P., Crowe, T. P. & Grenyer, B. F. S. (2018). Supervisor Perceptions of Relational Competence: Core Components and Alshawaf, A., Viventi, S., Qiu, W., D'Abaco, G., Nayagam, B., Erlichster, Developmental Considerations. Training And Education In Professional M., Chana, G., Everall, I., Ivanusic, J., Skafidas, E. & Dottori, M. (2018). Psychology, 12 (3), 135-141. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells. Scientific Reports, 8 603-1- Camfield, D. A., Fontana, R., Wesnes, K. A., Mills, J. & Croft, R. J. (2018). 603-12. Effects of aging and depression on mnemonic discrimination ability. Aging, Neuropsychology, and Cognition, 25 (3), 464-483. An, H., Du, X., Huang, X., Qi, L., Jia, Q., Yin, G., Xiao, C., Huang, X., Ning, Y., Cassidy, R. M., Wang, L., Soares, J. C. & Zhang, X. Camfield, D., Burton, T., De Blasio, F., Barry, R. & Croft, R. (2018). ERP (2018). Obesity, altered oxidative stress, and clinical correlates in chronic components associated with an indirect emotional stop signal task in healthy and schizophrenia patients. Translational Psychiatry, 8 (1), 258. depressed participants. International Journal of Psychophysiology, 124 12-25.
Andrews, J. L., Newell, K. A., Matosin, N., Huang, X. & Fernandez, F. Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., (2018). Perinatal administration of phencyclidine alters expression of Lingo-1 McAlary, L., Yerbury, J. J., O'Neill, P. M., Antonyuk, S. V., Banci, L. & signaling pathway proteins in the prefrontal cortex of juvenile and adult rats. Hasnain, S. Samar. (2018). The cysteine-reactive small molecule ebselen Neuronal Signaling, Sep 2 (3) NS20180059. facilitates effective SOD1 maturation. Nature Communications, 9 (1), 1693- 1-1693-9. Antonic, A., Dottori, M., Macleod, M. R., Donnan, G. A. & Howells, D. W. (2018). NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Carver, J. A., Ecroyd, H., Truscott, R. J. W., Thorn, D. C. & Holt, C. (2018). Stem Cell-Derived Human Neurons. Journal of Stroke and Cerebrovascular Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation Diseases, 27 (8), 2158-2165. by ATP-Independent Molecular Chaperones: Lens a-Crystallins and Milk Caseins. Accounts of Chemical Research, 51 (3), 745-752. Babic, I., Gorak, A., Engel, M., Sellers, D., Else, P., Osborne, A. L., Pai, N., Huang, X., Nealon, J. & Weston-Green, K. (2018). Liraglutide prevents Chang, H. & Chien, H. (2018). Effectiveness of group reminiscence therapy metabolic side-effects and improves recognition and working memory during for people living with dementia in a day care centers in Taiwan. Dementia: antipsychotic treatment in rats. Journal of Psychopharmacology, 32 (5), 578- the international journal of social research and practice, 17 (7), 924-935. 590. Chang, H., David, V. A., Britten, N. & De Vries, L. (2018). Better equipping Baker, A., Turner, A., Beck, A., Berry, K., Haddock, G., Kelly, P. & Bucci, S. healthcare professionals in pain management of people with dementia. (2018). Telephone-delivered psychosocial interventions targeting key health Australian Nursing and Midwifery Journal, 25 (7), 41-41. priorities in adults with a psychotic disorder: systematic review. Psychological Medicine, 48(16), 2637-2657. Chen, J., Chen, H., Feng, J., Zhang, L., Li, J., Li, R., Wang, S., Wilson, I., Jones, A., Tan, Y., Yang, F. & Huang, X. (2018). Association between Bakshi, I., Brown, S. H. J., Brandon, A. E., Suryana, E., Mitchell, T. W., hyperuricemia and metabolic syndrome in patients suffering from bipolar Turner, N. & Cooney, G. J. (2018). Increasing Acyl CoA thioesterase activity disorder. BMC Psychiatry, 18 (1), 390-1-390-7. alters phospholipid profle without effect on insulin action in skeletal muscle of rats. Scientific Reports, 8 13967-1-13967-12. Chronaki, G., Broyd, S., Garner, M., Benikos, N., Thompson, M., Sonuga- Barke, E. & Hadwin, J. (2018). The moderating effect of self-reported state Bancroft, R., Vella, S. & Pai, N. (2018). The systematic review of barriers and trait anxiety on the late positive potential to emotional faces in 6-11-year- to help-seeking in violent transgender relationships. Australian and New old children. Frontiers in Psychology, 9 (Feb), 1-14. Zealand Journal of Psychiatry, 52 (S1), 126. Cox, D., Whiten, D. R., Brown, J. W. P., Horrocks, M. H., San Gil, R., Beale, C., Broyd, S. J., Chye, Y., Schira, M. M., Galettis, P., Martin, J. H., Dobson, C. M., Klenerman, D., van Oijen, A. M. & Ecroyd, H. (2018). Yucel, M. & Solowij, N. (2018). Prolonged Cannabidiol Treatment Effects The small heat shock protein Hsp27 binds a-synuclein fibrils, preventing on Hippocampal Subfield Volumes in Current Cannabis Users. Cannabis and elongation and cytotoxicity. Journal of Biological Chemistry, 293 (12), Cannabinoid Research, 3 (1), 1-14. 4486-4497.
Bellot-Saez, A., Cohen, G., van Schaik, A., Ooi, L., Morley, J. W. & Coyle, M., Chang, H., Burns, P. & Traynor, V. (2018). Impact of Interactive Buskila, Y. (2018). Astrocytic modulation of cortical oscillations. Scientific Education on Health Care Practitioners and Older Adults at Risk of Delirium: Reports, 8 (1), 11565-1-11565-13. A Literature Review. Journal of Gerontological Nursing, 44 (8), 41-48.
Biddle, D., Kelly, P., Hermens, D. & Glozier, N. (2018). The association of Crowe, S. & Deane, F. (2018). Characteristics of mental health recovery insomnia with future mental illness: Is it just residual symptoms? Sleep Health, model implementation and managers’ and clinicians’ risk aversion. Journal of 4 352-359. Mental Health Training, Education and Practice, 13 (1), 22-33.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 37 D'Abaco, G. M., Mattei, C., Nasr, B., Hudson, E. J., Alshawaf, A. J., Garner, B. & Ooi, L. (2018). Wnt is here! Could Wnt signalling be Chana, G., Everall, I. P., Nayagam, B., Dottori, M. & Skafidas, E. (2018). promoted to protect against Alzheimer disease?. Journal of Neurochemistry, Graphene foam as a biocompatible scaffold for culturing human neurons. 144 (4), 356-359. Royal Society Open Science, 5 (3), 171364-1-171364-11. Goluza, I., Borchard, J., Wijesinghe, N., Wijesinghe, K. & Pai, N. (2018). Dalecki, A., Loughran, S. P., Verrender, A., Burdon, C. A., Taylor, N. A. To screen or not to screen? Vitamin D deficiency in chronic mental illness. S. & Croft, R. J. (2018). Does acute radio-frequency electromagnetic field Australasian Psychiatry, 26 (1), 56-59. exposure affect visual event-related potentials in healthy adults?. Clinical Neurophysiology, 129 (5), 901-908. Greenwood, L., Leung, S., Michie, P. T., Green, A., Nathan, P. J., Fitzgerald, P., Johnston, P., Solowij, N., Kulkarni, J. & Croft, R. J. (2018). The effects Davis, E. L., Deane, F. P., Barclay, G. D., Bourne, J. & Connolly, V. (2018). of glycine on auditory mismatch negativity in schizophrenia. Schizophrenia Attitudes of palliative care clinical staff toward prolonged grief disorder Research, 191 61-69. diagnosis and grief interventions. Palliative and Supportive Care, 16 (4), 388-395. Grenyer, B. F. S., Lewis, K. L., Fanaian, M. & Kotze, B. (2018). Treatment of personality disorder using a whole of service stepped care approach: Day, N., Hunt, A., Cortis-Jones, L. & Grenyer, B. (2018). Clinician attitudes A cluster randomized controlled trial. PLoS One, 13 (11), e0206472- towards borderline personality disorder: A 15-year comparison. Personality 1-e0206472-13. and Mental Health, 12 (4), 309-320. Hancock, S. E., Ailuri, R., Marshall, D. L., Brown, S. H. J., Saville, J. T., De Santis, M., Huang, X. & Deng, C. (2018). Early antipsychotic treatment Narreddula, V. R., Boase, N. R., Poad, B. L. J., Trevitt, A. J., Willcox, in juvenile rats elicits long-term alterations to the adult serotonin receptors. M. D. P., Kelso, M. J., Mitchell, T. W. & Blanksby, S. J. (2018). Mass Neuropsychiatric Disease and Treatment, 14 1569-1583. spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids. Journal of Lipid Research, 59 (8), Deane, F., Goff, R., Pullman, J., Sommer, J. & Lim, P. (2018). Changes in 1510-1518. Mental Health Providers’ Recovery Attitudes and Strengths Model Implementation Following Training and Supervision. International Journal of Mental Health and Huang, X., Weston-Green, K. & Yu, Y. (2018). Decreased 5-HT2cR and Addiction, https://doi.org/10.1007/s11469-018-9885-9 GHSR1a interaction in antipsychotic drug-induced obesity. Obesity Reviews, 19 (3), 396-405. Deane, F., Gonsalvez, C., Joyce, C. & Britt, E. (2018). Developmental trajectories of competency attainment amongst clinical psychology trainees Hunt, T., Wilson, C., Caputi, P., Wilson, I. & Woodward, A. (2018). across field placements. Journal of Clinical Psychology, 74 (9), 1641-1652. Patterns of Signs That Telephone Crisis Support Workers Associate with Suicide Risk in Telephone Crisis Line Callers. International Journal of Deane, F., McAlpine, E., Byrne, M., Davis, E. & Mortimer, C. (2018). Environmental Research and Public Health, 15 (2), 235-1-235-13. Are carer attitudes toward medications related to self-reported medication adherence amongst people with mental illness?. Psychiatry Research, 260 Ingram, I., Kelly, P. J., Deane, F. P., Baker, A. L. & Raftery, D. K. (2018). 158-163. Loneliness in Treatment-Seeking Substance-Dependent Populations: Validation of the Social and Emotional Loneliness Scale for Adults’ Short Version. Journal Destrée, L., Amiet, D., Carter, A., Lee, R., Lorenzetti, V., Segrave, R., Youssef, of Dual Diagnosis, 14 (4), 211-219. G., Solowij, N. & Yucel, M. (2018). Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. Iskra, W., Deane, F. P., Wahlin, T. & Davis, E. L. (2018). Parental perceptions of Drugs in Context, 7: 212541 barriers to mental health services for young people. Early Intervention in Psychiatry: the development, onset and treatment of emerging mental disorders, 12 125-134. Do-Ha, D., Buskila, Y. & Ooi, L. (2018). Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Jakabek, D., Power, B. D., Macfarlane, M. D., Walterfang, M., Velakoulis, Mechanisms and Paths to Therapy. Molecular Neurobiology, 55 (2), 1410- D., Van Westen, D., Latt, J., Nilsson, M., Looi, J. C. L. & Santillo, A. F. 1418. (2018). Regional structural hypo- and hyperconnectivity of frontal-striatal and frontal-thalamic pathways in behavioral variant frontotemporal dementia. Enge, T. Gabriel., Ecroyd, H., Jolley, D. F., Yerbury, J. J., Kalmar, B. & Human Brain Mapping, 39 (10), 4083-4093. Dosseto, A. (2018). Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in Johnston, C. L., Marzano, N. R., van Oijen, A. M. & Ecroyd, H. (2018). muscular denervation, with particular focus on muscle tissue. Molecular and Using Single-Molecule Approaches to Understand the Molecular Mechanisms Cellular Neuroscience, 88 319-329. of Heat-Shock Protein Chaperone Function. American Journal of Molecular Biology, 430 (22), 4525-4546. Engel, M., Balez, R., Sanz Munoz, S., Cabral-Da-Silva, M. Castro., Stevens, C. Helen., Bax, M., Do-Ha, D., Sidhu, K., Sachdev, P. & Ooi, L. (2018). Jovcevski, B., Aquilina, J., Benesch, J. L. P. & Ecroyd, H. (2018). The influence of Viral-free generation and characterization of a human induced pluripotent the N-terminal region proximal to the core domain on the assembly and chaperone stem cell line from dermal fibroblasts. Stem Cell Research, 32 135-138. activity of aB-crystallin. Cell Stress and Chaperones, 23 (5), 827-836.
Farrawell, N. E., Lambert-Smith, I., Mitchell, K., McKenna, J., McAlary, L., Karipidis, K., Elwood, M., Benke, G., Sanagou, M., Tjong, L. & Croft, R. J. Ciryam, P., Vine, K. L., Saunders, D. N. & Yerbury, J. J. (2018). SOD1A4V (2018). Mobile phone use and incidence of brain tumour histological types, aggregation alters ubiquitin homeostasis in a cell model of ALS. Journal of grading or anatomical location: A population based ecological study. BMJ Cell Science, 131 (11), jcs209122-1-jcs209122-14. Open, 8 (12), e024489-1-e024489-11.
Friedrich, M. G., Wang, Z., Schey, K. L. & Truscott, R. J. W. (2018). Kelly, P. J., Townsend, C. J., Osborne, B. A., Baker, A. L., Deane, F. P., DehydroalanylGly, a new post translational modification resulting from the Keane, C., Ingram, I. & Lunn, J. (2018). Predicting Intention to Use Nicotine breakdown of glutathione. Biochimica et Biophysica Acta - General Subjects, Replacement Therapy in People Attending Residential Treatment for Substance 1862 (4), 907-913. Dependence. Journal of Dual Diagnosis, 14 (2), 120-129.
Friedrich, M. G., Wang, Z., Schey, K. L. & Truscott, R. J. W. (2018). Kelly, P., Kyngdon, F., Ingram, I., Deane, F., Baker, A. & Osborne, B. Spontaneous cross-linking of proteins at aspartate and asparagine residues (2018). The Client Satisfaction Questionnaire-8: Psychometric properties is mediated via a succinimide intermediate. Biochemical Journal, 475 (20), in a cross-sectional survey of people attending residential substance abuse 3189-3200. treatment. Drug and Alcohol Review, 37 (1), 79-86.
Gao, Y., Wilson, G., Bozaoglu, K., Elefanty, A. G., Stanley, E. G., Dottori, Kelly, P., Robinson, L., Baker, A., Deane, F., Osborne, B., Hudson, S. & M. & Lockhart, P. J. (2018). Generation of RAB39B knockout isogenic human Hides, L. (2018). Quality of life of individuals seeking treatment at specialist embryonic stem cell lines to model RAB39B-mediated Parkinson's disease. non-government alcohol and other drug treatment services: A latent class Stem Cell Research, 28 161-164. analysis. Journal of Substance Abuse Treatment, 94 47-54.
38 2018-2019 ANNUAL REPORT Kielkopf, C. S., Low, J. K. K., Mok, Y., Bhatia, S., Palasovski, T., Oakley, Lucas, C. J., Galettis, P., Song, S., Solowij, N., Reuter, S. E., Schneider, J. & A. J., Whitten, A. E., Garner, B. & Brown, S. H. J. (2018). Identification of Martin, J. H. (2018). Cannabinoid Disposition After Human Intraperitoneal a novel tetrameric structure for human apolipoprotein-D. Journal of Structural Use: An Insight Into Intraperitoneal Pharmacokinetic Properties in Metastatic Biology, 203 205-218. Cancer. Clinical Therapeutics: the international peer-reviewed journal of drug therapy, 40 (9), 1442-1447. Kim, W. Scott., Fu, Y., Dobson-Stone, C., Hsiao, J., Shang, K., Hallupp, M., Schofield, P. R., Garner, B., Karl, T. & Kwok, J. B. J. (2018). Effect Lum, J. S., Millard, S. J., Frank, E., Matosin, N., Huang, X., Ooi, L. & of Fluvoxamine on Amyloid-ß Peptide Generation and Memory. Journal of Newell, K. A. (2018). Chronic Adolescent CDPPB Treatment Alters Short- Alzheimer's Disease, 62 (4), 1777-1787. Term, but not Long-Term, Glutamatergic Receptor Expression. Neurochemical Research, 43 (8), 1-9. Kitchingman, T. A., Wilson, C. J., Caputi, P., Wilson, I. & Woodward, A. (2018). Telephone crisis support workers' psychological distress and Lum, J. S., Millard, S. J., Huang, X., Ooi, L. & Newell, K. A. (2018). impairment: A systematic review. Crisis: the Journal of Crisis Intervention and A postmortem analysis of NMDA ionotropic and group 1 metabotropic Suicide Prevention, 39 (1), 13-26. glutamate receptors in the nucleus accumbens in schizophrenia. Journal of Psychiatry and Neuroscience, 43 (2), 102-110. Kitchingman, T. A., Wilson, C. J., Woodward, A., Caputi, P. & Wilson, I. (2018). Telephone Crisis Support Workers' Intentions to Use Recommended Lum, J. S., Pan, B., Deng, C., Huang, X., Ooi, L. & Newell, K. A. (2018). Skills while Experiencing Functional Impairment. Crisis: the Journal of Crisis Effects of short- and long-term aripiprazole treatment on Group I mGluRs in Intervention and Suicide Prevention, 39 (3), 218-223. the nucleus accumbens: Comparison with haloperidol. Psychiatry Research, 260 152-157. Kitchingman, T. Ashlea., Caputi, P., Woodward, A., Wilson, C. Joy. & Wilson, I. (2018). The impact of their role on telephone crisis support Marceau, E. M., Meuldijk, D., Townsend, M. L., Solowij, N. & Grenyer, B. workers' psychological wellbeing and functioning: Quantitative findings from F. S. (2018). Biomarker correlates of psychotherapy outcomes in borderline a mixed methods investigation. PLoS ONE, 13 (12), e0207645. personality disorder: A systematic review. Neuroscience and Biobehavioral Reviews, 94 166-178. Kodera, S., Hirata, A., Funahashi, D., Watanabe, S., Jokela, K. & Croft, R. J. (2018). Temperature Rise for Brief Radio-Frequency Exposure Below 6 Marceau, E., Kelly, P. & Solowij, N. (2018). The relationship between GHz. IEEE Access, 6 65737-65746. executive functions and emotion regulation in females attending therapeutic community treatment for substance use disorder. Drug and Alcohol Kurtz, A., Seltmann, S., Bairoch, A., Bittner, M., Bruce, K., Capes-Davis, Dependence, 182 58-66. A., Clarke, L., Crook, J. M., Daheron, L., Dewender, J., Faulconbridge, A., Fujibuchi, W., Gutteridge, A., Hei, D. J., Kim, Y., Kim, J., Kolb-Kokocinski, Matosin, N., Halldorsdottir, T. & Binder, E. B. (2018). Understanding the A., Lekschas, F., Lomax, G. P., Loring, J. F., Ludwig, T., Mah, N., Matsui, T., Molecular Mechanisms Underpinning Gene by Environment Interactions in Muller, R., Parkinson, H., Sheldon, M., Smith, K., Stachelscheid, H., Stacey, Psychiatric Disorders: The FKBP5 Model. Biological Psychiatry, 83 (10), G., Streeter, I., Veiga, A. & Xu, R. (2018). A Standard Nomenclature for 821-830. Referencing and Authentication of Pluripotent Stem Cells. Stem Cell Reports, 10 (1), 1-6. Matosin, N., Martinelli, S., Cruceanu, C., Turecki, G. & Binder, E. (2018). The Postmortem Human Brain to Characterize Novel Drug Targets for Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Psychiatric Disorders: Using FKBP5 as an Example. Biological Psychiatry, 83 Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., (9), S28-S29. Yerbury, J. J. et al (2018). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Matosin, N., Newell, K. Anne., Quidé, Y., Andrews, J. Lee., Teroganova, Cellular and Molecular Life Sciences, 75 (2), 335-354. N., Green, M. Jayne. & Fernandez, F. (2018). Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein Lepers, R., Li, F. & Stapley, P. James. (2018). Swimrun: An emerging new levels in schizophrenia. Brain Imaging and Behavior: an international journal, endurance sport. Movement And Sports Sciences — Science Et Motricite, 12 (2), 509-517. 100 (2), 53-58. Mattei, C., Alshawaf, A., D'Abaco, G., Nayagam, B. & Dottori, M. Lepers, R., Stapley, P. J. & Cattagni, T. (2018). Variation of Age-Related (2018). Generation of Neural Organoids from Human Embryonic Stem Changes in Endurance Performance Between Modes of Locomotion in Cells Using the Rotary Cell Culture System: Effects of Microgravity on Men: An Analysis of Master World Records. International Journal Of Sports Neural Progenitor Cell Fate. Stem Cells And Development, 27 (12), 848- Physiology And Performance, 13 (3), 394-397. 857.
Li, X., Tian, X., Lv, L., Hei, G., Huang, X., Fan, X., Zhang, J., Zhang, J., McCarthy, K., Steele, K. R., Jarman, H., Bourke, M., Townsend, M. L. & Pang, L. & Song, X. (2018). Microglia activation in the offspring of prenatal Grenyer, B. F. S. (2018). Parenting with Personality Disorder and Complex Poly I: C exposed rats: a PET imaging and immunohistochemistry study. Mental Health Issues Intervention: A Manual for Health Professionals General Psychiatry, 2018;31:e000006. (2nd Ed). Wollongong, Australia: University of Wollongong. www. projectairstrategy.org Lian, J. & Deng, C. (2018). The effects of antipsychotics on the density of cannabinoid receptors in selected brain regions of male and female McWilliams, N., Grenyer, B. F. S. & Shedler, J. (2018). Personality in PDM- adolescent juvenile rats. Psychiatry Research, 266 317-322. 2: Controversial Issues. Psychoanalytic Psychology, 35 (3), 299-305.
Liang, H., Wang, H., Wang, S., Francis, R., Paxinos, G. & Huang, X. Miller, C., Lewis, K., Huxley, E., Townsend, M. & Grenyer, B. (2018). A (2018). 3D imaging of PSD-95 in the mouse brain using the advanced 1-year follow-up study of capacity to love and work: What components of CUBIC method. Molecular Brain, 11 (1), 50-1-50-4. borderline personality disorder most impair interpersonal and vocational functioning?. Personality and Mental Health, 12 (4), 334-344. Liu, Y., Antonic, A., Yang, X., Korte, N., Lim, K., Michalska, A. E., Dottori, M. & Howells, D. W. (2018). Derivation of phenotypically diverse neural Mills, J. G., Thomas, S. J., Larkin, T. A., Pai, N. B. & Deng, C. (2018). culture from hESC by combining adherent and dissociation methods. Journal Problematic eating behaviours, changes in appetite, and weight gain in of Neuroscience Methods, 308 286-293. Major Depressive Disorder: The role of leptin. Journal of Affective Disorders, 240 137-145. Liu, Y., Zhang, Y., Zheng, X., Fang, T., Yang, X., Luo, X., Guo, A., Newell, K. A., Huang, X. & Yu, Y. (2018). Galantamine improves cognition, Mohi, S. R., Deane, F. P., Bailey, A., Mooney-Reh, D. & Ciaglia, D. hippocampal inflammation, and synaptic plasticity impairments induced by (2018). An exploration of values among consumers seeking treatment for lipopolysaccharide in mice. Journal of Neuroinflammation, 15 (1), 112-1- borderline personality disorder. Borderline Personality Disorder and Emotion 112-15. Dysregulation, 5 8-1-8-10.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 39 Mok, S., Condello, C., Freilich, R., Gillies, A., Arhar, T., Oroz, J., Kadavath, Ronningstam, E. F., Keng, S., Ridolfi, M. Elena., Arbabi, M. & Grenyer, B. F. H., Julien, O., Assimon, V. A., Rauch, J. N., Dunyak, B. M., Lee, J., Tsai, F. T. S. (2018). Cultural Aspects in Symptomatology, Assessment, and Treatment F., Wilson, M. R., Zweckstetter, M., Dickey, C. A. & Gestwicki, J. E. (2018). of Personality Disorders. Current Psychiatry Reports, 20 (4), 22-1-22-10. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology, 25 (5), Russell, A. P., Ghobrial, L., Ngo, S., Yerbury, J., Zacharewicz, E., Chung, 384-393. R. & Lamon, S. (2018). Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis Nasr, B., Chatterton, R., Yong, J. Hsien Ming., Jamshidi, P., D'Abaco, G. mice. Muscle & Nerve, 57 (5), 838-847. Marisa., Bjorksten, A. Robin., Kavehei, O., Chana, G., Dottori, M. & Skafidas, E. (2018). Self-organized nanostructure modified microelectrode Sagar, S., Adem, S., Struchen, B., Loughran, S., Brunjes, M., Arangua, L., for sensitive electrochemical glutamate detection in stem cells-derived brain Dalvie, M., Croft, R., Jerrett, M., Moskowitz, J., Kuo, T. & Roosli, M. (2018). organoids. Biosensors, 8 (1), 14-1-14-11. Comparison of radiofrequency electromagnetic field exposure levels in different everyday microenvironments in an international context. Environment Olsson, M., Friesen, C. R., Rollings, N., Sudyka, J., Lindsay, W., Whittington, International, 114 297-306. C. M. & Wilson, M. (2018). Long-term effects of superoxide and DNA repair on lizard telomeres. Molecular Ecology, 27 (24), 5154-5164. Sanz Munoz, S., Balez, R., E Castro Cabral Da Silva, M., Berg, T., Engel, M., Bax, M., Do-Ha, P., Stevens, C. H., Greenough, M., Bush, A. & Ooi, L. Pai, N. & Vella, S. (2018). Can one spring back from psychosis? The role (2018). Generation and characterization of human induced pluripotent stem of resilience in serious mental illness. Australian and New Zealand Journal of cell lines from a familial Alzheimer's disease PSEN1 A246E patient and a Psychiatry, 52 (11), 1093-1094. non-demented family member bearing wild-type PSEN1. Stem Cell Research, 31 227-230. Pai, N. & Warden, M. (2018). Early Australian experience in the maintenance of schizophrenia management with 3-monthly paliperidone Sanz Munoz, S., Li, H., Ruberu, K., Chu, Q., Saghatelian, A., Ooi, L. & palmitate. Australasian Psychiatry, 26 (6), 628-634. Garner, B. (2018). The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates Pai, N. B. & Vella, S. C. (2018). Comparison of the Outcomes of Patients neuritogenesis. Journal of Biological Chemistry, 293 (11), 4071-4084. with Severe Mental Illness by Legal Status: Community Treatment Orders vs. Voluntary Outpatient Treatment. WFSBP 2018 (pp. 123-123). Schranz, N., Glennon, V., Evans, J., Gomersall, S., Hardy, L., Hesketh, K. D., Lubans, D., Ridgers, N. D., Straker, L., Stylianou, M., Tomkinson, G. R., Pai, N. B. (2018). Brexpiprazole joins growing group of approved Vella, S., Ziviani, J. & Olds, T. (2018). Results from Australia's 2018 Report antipsychotics: what does our early experience say?. Australian and New Card on Physical Activity for Children and Youth. Journal Of Physical Activity Zealand Journal of Psychiatry, 52 (S1), 147. & Health, 15 (Suppl 2), S315-S317.
Pai, N. Brahmavar., Vella, S. & Dawes, K. (2018). The Clinical Assessment Sheean, R. K., McKay, F. C., Cretney, E., Bye, C. R., Perera, N. D., Tomas, of Impulsivity. Archives of Medicine and Health Sciences, 6 (1), 95-98. D., Weston, R. A., Scheller, K. J., Djouma, E., Menon, P., Schibeci, S. D., Marmash, N., Yerbury, J. J., Nutt, S. L., Booth, D. R., Stewart, G. J., Palmisano, S. & Riecke, B. (2018). The search for instantaneous vection: An Kiernan, M. C., Vucic, S. & Turner, B. J. (2018). Association of Regulatory oscillating visual prime reduces vection onset latency. PLoS One, 13 (5), 1-26. T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model. Jama Neurology, 75 (6), 681- Palmisano, S., Arcioni, B. & Stapley, P. (2018). Predicting vection and 689. visually induced motion sickness based on spontaneous postural activity. Experimental Brain Research, 236 315-329. Sheppard, R., Deane, F. & Ciarrochi, J. (2018). Unmet need for professional mental health care among adolescents with high psychological distress. Pan, B., Lian, J. & Deng, C. (2018). Chronic antipsychotic treatment Australian And New Zealand Journal Of Psychiatry, 52 (1), 59-67. differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and Shohayeb, B., Lim, N. Rui., Ho, U., Xu, Z., Dottori, M., Quinn, L. & γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats. Journal Ng, D. (2018). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain of Psychopharmacology, 32 (11), 1252-1263. Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Molecular Neurobiology, 55 (7), 5409-5424. Perera, P. G. Tharushi., Nguyen, T., Dekiwadia, C., Wandiyanto, J. V., Sbarski, I., Bazaka, O., Bazaka, K., Crawford, R. J., Croft, R. J. & Ivanova, Solowij, N. (2018). Psychotomimetic and Cognitive Effects of Cannabis E. P. (2018). Exposure to high-frequency electromagnetic field triggers rapid Use in the General Population. In M. Compton & M. Manseau (Eds.), The uptake of large nanosphere clusters by pheochromocytoma cells. International Complex Connection between Cannabis and Schizophrenia (pp. 129-155). Journal of Nanomedicine, 13 8429-8442. United States: Academic Press.
Pickard, J., Townsend, M., Caputi, P. & Grenyer, B. (2018). Top-down and bottom- Solowij, N., Broyd, S. J., Beale, C., Prick, J., Greenwood, L., van Hell, up: The role of social information processing and mindfulness as predictors in H. H., Suo, C., Galettis, P., Pai, N. B., Fu, S., Croft, R. J., Martin, J. H. & maternal-infant interaction. Infant Mental Health Journal, 39 (1), 44-54. Yucel, M. (2018). Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: Pokrishevsky, E., McAlary, L., Farrawell, N. E., Zhao, B., Sher, M., A Pragmatic Open-Label Clinical Trial. Cannabis and Cannabinoid Research, Yerbury, J. J. & Cashman, N. R. (2018). Tryptophan 32-mediated SOD1 3 (1), 21-34. aggregation is attenuated by pyrimidine-like compounds in living cells. Scientific Reports, 8 (1), 15590-1-15590-12. Solowij, N., Galettis, P., Broyd, S., de Krey, P. & Martin, J. (2018). Second- Hand Exposure of Staff Administering Vaporised Cannabinoid Products to Quide, Y., Matosin, N., Atkins, J. R., Fitzsimmons, C., Cairns, M., Carr, V. J. Patients in a Hospital Setting. Drugs in R and D, 18 (1), 41-44. & Green, M. J. (2018). Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants. Spindler, D., Allen, M., Vella, S. & Swann, C. (2018). The psychology of Progress in Neuro-Psychopharmacology and Biological Psychiatry, 82 (2), elite cycling: a systematic review. Journal of Sports Sciences, 36 (17), 1943- 12-20. 1954.
Quinlan, E., Deane, F. & Crowe, T. (2018). Interpersonal problems amongst Stallman, H. M. & Wilson, C. J. (2018). Can the mental health of mental health carers: a qualitative study. Social Work in Mental Health, Australians be improved by dual strategy for promotion and prevention?. 16:5, 518-539. Australian and New Zealand Journal of Psychiatry, 52 (6), 602-605.
Quinlan, E., Deane, F. & Crowe, T. (2018). Pilot of an acceptance and Stamenkovic, A., Stapley, P. J., Robins, R. & Hollands, M. A. (2018). Do commitment therapy and schema group intervention for mental health carer's postural constraints affect eye, head, and arm coordination?. Journal of interpersonal problems. Journal of Contextual Behavioral Science, 9 53-62. Neurophysiology, 120 (4), 2066-2082.
40 2018-2019 ANNUAL REPORT Svahn, A. J., Don, E. K., Badrock, A. P., Cole, N. J., Graeber, M. B., Wolstencroft, K. E., Deane, F. P., Jones, C. L., Zimmermann, A. & Cox, M. Yerbury, J. J., Chung, R. & Morsch, M. (2018). Nucleo-cytoplasmic (2018). Consumer and staff perspectives of the implementation frequency transport of TDP-43 studied in real time: impaired microglia function leads and value of recovery and wellbeing oriented practices. International Journal to axonal spreading of TDP-43 in degenerating motor neurons. Acta of Mental Health Systems, 12 (1), 60-1-60-14. Neuropathologica, 136 (3), 445-459. Xie, Y. & Huang, X. (2018). Commentary: GLYX-13 Ameliorates Swann, C., Piggott, D., Schweickle, M. & Vella, S. (2018). A Review of Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Scientific Progress in Flow in Sport and Exercise: Normal Science, Crisis, Hippocampal NR2B and DISC1. Frontiers in Molecular Neuroscience, 11 and a Progressive Shift. Journal of Applied Sport Psychology, 30 (3), 315-1-315-3. 249-271. Yan, Y., Sencadas, V., Jin, T., Huang, X., Lie, W., Wei, D. & Jiang, Z. Swann, C., Telenta, J., Draper, G., Liddle, S., Fogarty, A., Hurley, D. & (2018). Effect of multi-walled carbon nanotubes on the cross-linking density Vella, S. (2018). Youth sport as a context for supporting mental health: of the poly(glycerol sebacate) elastomeric nanocomposites. Journal of Colloid Adolescent male perspectives. Psychology of Sport and Exercise, 35 and Interface Science, 521 24-32. 55-64. Yu, V., Bhattacharya, D., Webster, A., Bauskar, A., Flowers, C., Heur, M., Taylor, H. E., Deane, F. P. & Blackman, R. (2018). Feasibility of Using Short Chintala, S. K., Itakura, T., Wilson, M. R., Barr, J. T., Jeong, S., Wang, M. Message Service (SMS) to Collect Outcome Data in an Australian Residential & Fini, M. Elizabeth. (2018). Clusterin from human clinical tear samples: Alcohol and Drug Treatment Service. Addictive Disorders and Their Treatment, Positive correlation between tear concentration and Schirmer strip test results. 17 (2), 65-75. The Ocular Surface, 16 (4), 478-486.
Torres, M., Deane, F. P., Sng, R. & Quinlan, E. (2018). Black Box Parenting Yuan, X., Zhang, P., Wang, Y., Liu, Y., Li, X., Kumar, B., Hei, G., Lv, Program for Substance-Abusing Fathers: A Feasibility Study. Australian and L., Huang, X., Fan, X. & Song, X. (2018). Changes in metabolism and New Zealand Journal of Family Therapy, 39 (4), 472-486. microbiota after 24-week risperidone treatment in drug naïve, normal weight patients with first episode schizophrenia. Schizophrenia Research, 201 Townsend, M. L., Gray, A. S., Lancaster, T. M. & Grenyer, B. F. S. (2018). A 299-306. whole of school intervention for personality disorder and self-harm in youth: a pilot study of changes in teachers' attitudes, knowledge and skills. Borderline Zandl-Lang, M., Fanaee-Danesh, E., Sun, Y., Albrecher, N. M., Gali, Personality Disorder and Emotion Dysregulation, 5 (17), 1-9. C., Cancar, I., Kober, A., Tam-Amersdorfer, C., Stracke, A., Storck, S. M., Saeed, A., Stefulj, J., Pietrzik, C. U., Wilson, M. R., Björkhem, I. & Townsend, M. L., Hasleton, S. J., Marceau, E. M., Gray, A. S. & Panzenboeck, U. (2018). Regulatory effects of simvastatin and apoJ on APP Grenyer, B. F. S. (2018). Adolescent Intervention: Guide for Clinicians. processing and amyloid-ß clearance in blood-brain barrier endothelial cells. Wollongong, Australia: University of Wollongong. https://ro.uow.edu. Biochimica et Biophysica Acta — Molecular and Cell Biology of Lipids, au/uowbooks/21/ 1863 (1), 40-60.
Truscott, R. J. W. & Friedrich, M. G. (2018). Can The Fact That Myelin Zeleke, B. M., Brzozek, C., Bhatt, C. Raj., Abramson, M. J., Croft, R. J., Proteins Are Old And Break Down Explain The Origin Of Multiple Sclerosis In Freudenstein, F., Wiedemann, P. & Benke, G. (2018). Personal Exposure Some People?. Journal of Clinical Medicine, 7 (9), 281-1-281-12. to Radio Frequency Electromagnetic Fields among Australian Adults. International Journal of Environmental Research and Public Health, 15 (10), Vella, S., Gardner, L., Kemp, B. & Swann, C. (2018). Health-related quality 2234-1-2234-10. of life as a longitudinal mediator of the relationship between participation in organised sports and adiposity among young people. Preventive Medicine Zhu, P., Zhang, Z., Huang, X., Liang, S., Khandekar, N., Song, Z. & Lin, Reports, 12 66-70. S. (2018). RANKL reduces body weight and food intake via the modulation of hypothalamic NPY/CART expression. International Journal of Medical Verrender, A., Loughran, S. P., Hillert, L., Rubin, G. & Croft, R. J. (2018). Sciences, 15 (10), 969-977. IEI-EMF provocation case studies: A novel approach to testing sensitive individuals. Bioelectromagnetics. Bioelectromagnetics, 39 (2), 132-143. Zhu, P., Zhang, Z., Huang, X., Shi, Y., Khandekar, N., Yang, H., Liang, S., Song, Z. & Lin, S. (2018). Cold exposure promotes obesity and impairs Verrender, A., Loughran, S., Dalecki, A., Freudenstein, F. & Croft, R. glucose homeostasis in mice subjected to a highfat diet. Molecular Medicine (2018). Can explicit suggestions about the harmfulness of EMF exposure Reports, 18 3923-3931. exacerbate a nocebo response in healthy controls?. Environmental Research, 166 409-417.
Viventi, S. & Dottori, M. (2018). Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies. International Journal Of Biochemistry & Cell Biology, 100 61-68.
Weston-Green, K., Babic, I., De Santis, M., Pan, B., Montgomery, M. K., Mitchell, T., Huang, X. & Nealon, J. (2018). Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration. British Journal of Biomedical Science, 25 (1), 40-1-40-11.
Weston-Green, K., Osborne, A. L. & Newell, K. (2018). Could an allied health care approach reduce the unacceptable incidence of suicide after psychiatric hospital discharge?. Bipolar Disorders: an international journal of psychiatry and neurosciences, 20 (4), 403-404.
Whiten, D., Cox, D., Horrocks, M. H., Taylor, C. G., De, S., Flagmeier, P., Tosatto, L., Kumita, J. R., Ecroyd, H., Dobson, C. M., Klenerman, D. & Wilson, M. R. (2018). Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic a-Synuclein Oligomers. Cell Reports, 23 3492-3500.
Whiting, D. L., Deane, F. P., Simpson, G. K., Ciarrochi, J. & McLeod, H. J. (2018). Acceptance and Commitment Therapy delivered in a dyad after a severe traumatic brain injury: A feasibility study. Clinical Psychologist, 22 (2), 230-240.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 41 Chronic conditions and lifestyle Blunden, S., Magee, C., Attard, K., Clarkson, L., Caputi, P. & Skinner, T. (2018). Sleep schedules and school performance in Indigenous Australian children. Sleep Health, 4 135-140. Agarwal, E., Ferguson, M., Banks, M., Vivanti, A., Batterham, M., Bauer, J., Capra, S. & Isenring, E. (2018). Malnutrition, poor food intake, and adverse Brazendale, K., Beets, M. W., Rowlands, A. V., Chandler, J. L., Fairclough, healthcare outcomes in non-critically ill obese acute care hospital patients. S. J., Boddy, L. M., Olds, T. S., Parfitt, G., Noonan, R. J., Downs, S. J. & Clinical Nutrition, 38 (2), 759-766. Cliff, D. P. (2018). Converting between estimates of moderate-to-vigorous physical activity derived from raw accelerations measured at the wrist and Al Mutair, A., Al Mohaini, M., Fernandez, R., Moxham, L., Lapkin, S. & ten from ActiGraph counts measured at the hip: the Rosetta Stone. Journal of Ham-Baloyi, W. (2018). Psychometric testing of the mental health inventory Sports Sciences, 36 (22), 2603-2607. in an Arabian context: Cross-cultural validation study. Nursing Open, 5 (3), 376-383. Brett, L., Stapley, P., Meedya, S. & Traynor, V. (2018). Sufficient exercise for Australians living with dementia in residential aged care facilities is lacking: An, H., Zhou, L., Yu, Y., Fan, H., Fan, F., Tan, S., Wang, Z., Z, B., Shi, J., An exploration of policy incoherence. Australian and New Zealand Journal Yang, F., Zhang, X., Tan, Y. & Huang, X. (2018). Serum NCAM levels and of Public Health, 42 (5), 427-429. cognitive deficits in first episode schizophrenia patients versus health controls. Schizophrenia Research, 192 457-458. Brett, L., Traynor, V., Stapley, P. & Meedya, S. (2018). Exercise and dementia in nursing homes: Views of staff and family carers. Journal of Aging Andruschko, J., Okely, A. D. & Pearson, P. (2018). A school-based physical and Physical Activity, 26 (1), 89-96. activity and motor development program for low-fit adolescent females: The Sport4Fun pilot randomized controlled trial. Journal of Motor Learning and Buchanan, L., Kelly, B., Yeatman, H. & Kariippanon, K. (2018). The effects Development, 6 (2), 345-356. of digital marketing of unhealthy commodities on young people: A systematic review. Nutrients, 10 (2), 148-1-148-19. Ashley, C., Brown, A., Halcomb, E. & Peters, K. (2018). Registered nurses transitioning from acute care to primary healthcare employment: A qualitative Buchanan, L., Yeatman, H., Kelly, B. & Kariippanon, K. (2018). A thematic insight into nurses’ experiences. Journal of Clinical Nursing, 27 (3-4), 661-668. content analysis of how marketers promote energy drinks on digital platforms to young Australians. Australian and New Zealand Journal of Public Health, Ashley, C., Halcomb, E., Brown, A. & Peters, K. (2018). Experiences of 42 (6), 530-531. registered nurses transitioning from employment in acute care to primary health care — quantitative findings from a mixed-methods study. Journal of Buchanan, L., Yeatman, H., Kelly, B. & Kariippanon, K. (2018). Digital Clinical Nursing, 27 (1-2), 355-362. Promotion of Energy Drinks to Young Adults Is More Strongly Linked to Consumption Than Other Media. Journal of Nutrition Education and Ashley, C., Peters, K., Brown, A. & Halcomb, E. (2018). Work satisfaction Behavior, 50 (9), 888-895. and future career intentions of experienced nurses transitioning to primary health care employment. Journal of Nursing Management, 26 (6), 663-670. Burns, P., Jones, S. C., Caputi, P. & Iverson, D. (2018). Are older Australians with chronic diseases online?. Health Promotion Journal of Australia, 29 (1), Astell-Burt, T. & Feng, X. (2018). Geographic variation in the impact of a type 72-78. 2 diabetes diagnosis on behavioural change: A longitudinal study using random effects within-between (REWB) models. Health and Place, 54 164-169. Bussey, M., de Castro, M., Aldabe, D. & Shemmell, J. (2018). Sex differences in anticipatory postural adjustments during rapid single leg lift. Astell-Burt, T. & Feng, X. (2018). Is the risk of developing Alzheimer's Human Movement Science, 57 417-425. disease really higher in rural areas? A multilevel longitudinal study of 261,669 Australians aged 45 years and older tracked over 11 years. Caldwell, J. N., van den Heuvel, A. M. J., Kerry, P., Clark, M. J., Peoples, Health and Place, 54 132-137. G. E. & Taylor, N. A.S. (2018). A vascular mechanism to explain thermally mediated variations in deep-body cooling rates during immersion treatment Astell-Burt, T., Rowbotham, S. & Hawe, P. (2018). Communicating the of profoundly hyperthermic individuals. Experimental Physiology, 103 (4), benefits of population health interventions: The health effects can be on par 512-522. with those of medication. SSM — Population Health, 6 54-62. Calma, K. B., Halcomb, E. & Stephens, M. (2018). An exploration of the Astell-Burt, T., Zhang, M., Feng, X., Wang, L., Li, Y., Page, A., Zhou, M. experiences of Australian Grey Nomads travelling with chronic conditions. & Wang, L. (2018). Geographical inequality in tobacco control in China: Australian Journal of Primary Health, 24 183-188. Multilevel evidence from 98 058 participants. Nicotine and Tobacco Research, 20 (6), 755-765. Carter, R., Salamonson, Y., Ramjan, L. M. & Halcomb, E. (2018). Students use of exemplars to support academic writing in higher education: An Azzam, N., Oei, J., Adams, S., Bajuk, B., Hilder, L., Mohamed, A., Wright, integrative review. Nurse Education Today, 65 87-93. I. M. R. & Holland, A. J. A. (2018). Influence of early childhood burns on school performance: An Australian population study. Archives of Disease in Chandler, J., Beets, M., Saint-Maurice, P., Weaver, R., Cliff, D., Childhood, 103 (5), 444-451. Drenowatz, C., Moore, J. B., Sui, X. & Brazendale, K. (2018). Wrist- Based Accelerometer Cut-Points to Identify Sedentary Time in 5-11-Year-Old Bagherinia, M., Meedya, S. & Mirghafourvand, M. (2018). Association Children. Children, 5 (10), 137-1-137-8. between maternal sense of competence and self-efficacy in primiparous women during postpartum period. Shiraz E Medical Journal, 19 (3), Charlton, K. E., Ware, L. J., Baumgartner, J., Cockeran, M., Schutte, e59286-1-e59286-8. A. E., Naidoo, N. & Kowal, P. (2018). Iodine Status Assessment in South African Adults According to Spot Urinary Iodine Concentrations, Barbato, M., Barclay, G., Potter, J. & Yeo, W. (2018). Breakthrough Prediction Equations, and Measured 24-h Iodine Excretion. Nutrients, 10 Medication in Unresponsive Palliative Care Patients: Indications, Practice, (6), e736-1-e736-14. and Efficacy. Journal of Pain and Symptom Management, 56 (6), 944-950. Charlton, K., Ware, L. Jayne., Baumgartner, J., Cockeran, M., Schutte, A. Barrett, E. M., Probst, Y. C. & Beck, E. J. (2018). Cereal fibre intake in E., Naidoo, N. & Kowal, P. (2018). How will South Africa’s mandatory Australia: a cross sectional analysis of the 2011-12 National Nutrition and salt reduction policy affect its salt iodisation programme? A cross-sectional Physical Activity Survey. International Journal of Food Sciences and Nutrition, analysis from the WHO-SAGE Wave 2 Salt & Tobacco study. BMJ Open, 8 69 (5), 619-627. (3), 020404-1-020404-9.
Barrett, E. M., Probst, Y. C. & Beck, E. J. (2018). Creation of a database for Cherry, J. J., Rich, W. C. & McLennan, P. L. (2018). Telemedicine in remote the estimation of cereal fibre content in foods. Journal of Food Composition Australia: The Royal Flying Doctor Service (RFDS) Medical Chest Program and Analysis, 66 1-6. as a marker of remote health. Rural and Remote Health, 18 (4), 4502-4512.
42 2018-2019 ANNUAL REPORT Chiavaroli, N. G., Beck, E. J., Itsiopoulos, C., Wilkinson, P., Gibbons, K. & Eiby, Y. A., Shrimpton, N. Y., Wright, I. M. R., Lumbers, E. R., Colditz, P. Palermo, C. (2018). Development and validation of a written credentialing B., Duncombe, G. J. & Lingwood, B. E. (2018). Reduced blood volume examination for overseas-educated dietitians. Nutrition & Dietetics, 75 (2), decreases cerebral blood flow in preterm piglets. Journal of Physiology, 596 235-243. (23), 6033-6041.
Chigavazira, J., Fernandez, R., Mackay, M. & Lapkin, S. (2018). Elder, G. J., Malik, A. & Lambert, K. (2018). Role of dietary phosphate Adaptation and validation of the clinical supervision self-assessment tool restriction in chronic kidney disease. Nephrology, 23 (12), 1107-1115. among registered nurses. Nurse Education Today, 70 28-33. Elgellaie, A., Ashcroft, E. & Larkin, T. A. (2018). Effects of thickness of Cliff, D. P., Howard, S. J., Radesky, J. S., McNeill, J. & Vella, S. A. muscle and subcutaneous fat on efficacy of gluteal intramuscular injection (2018). Early Childhood Media Exposure and Self-Regulation: Bidirectional sites. British Journal of Nursing, 27 (6), 300-305. Longitudinal Associations. Academic Pediatrics, 18 (7), 813-819. Ellis, Y. G., Cliff, D. P. & Okely, A. D. (2018). Childcare Educators' Coltman, C. E., Steele, J. R. & McGhee, D. E. (2018). Can breast Perceptions of and Solutions to Reducing Sitting Time in Young Children: A characteristics predict upper torso musculoskeletal pain?. Clinical Qualitative Study. Early Childhood Education Journal, 46 (4), 377-385. Biomechanics, 53 46-53. Ellwood, L., Torun, G., Bahar, Z. & Fernandez, R. (2018). Effectiveness of Coltman, C. E., Steele, J. R. & McGhee, D. E. (2018). Effects of age and flavonoid rich fruits for hypertension in adults: a systematic review protocol. body mass index on breast characteristics: a cluster analysis. Ergonomics, 61 The JBI Database of Systematic Reviews and Implementation Reports, 16 (9), 1232-1245. (11), 2103-2108.
Coltman, C. E., Steele, J. R. & McGhee, D. E. (2018). Which Bra Farrell, K., Fernandez, R., Salamonson, Y., Griffiths, R. & Holmes-Walker, D. Components Contribute to Incorrect Bra Fit in Women Across a Range of J. (2018). Health outcomes for youth with type 1 diabetes at 18-months and Breast Sizes?. Clothing and Textiles Research Journal, 36 (2), 78-90. 30-months post transition from pediatric to adult care. Diabetes Research and Clinical Practice, 139 163-169. Deavin, N., McMahon, A., Walton, K. & Charlton, K. (2018). “Breaking Barriers, Breaking Bread”: Pilot study to evaluate acceptability of a school Farrer, O., Yaxley, A., Walton, K. & Miller, M. (2018). Characteristics of breakfast program utilising donated food. Nutrition and Dietetics, 75 500-508. older adults with diabetes: What does the current aged care resident look like?. Nutrition and Dietetics, 75 (5), 494-499. Dendup, T., Feng, X., Clingan, S. & Astell-Burt, T. (2018). Environmental risk factors for developing type 2 diabetes mellitus: A systematic review. Feng, X. & Astell-Burt, T. (2018). Residential green space quantity and International Journal of Environmental Research and Public Health, 15 (1), quality and symptoms of psychological distress: A 15-year longitudinal study 78-1-78-25. of 3897 women in postpartum. BMC Psychiatry, 18 (1), 348-1-348-11.
Dixon, F., Ziegler, D. S., Bajuk, B., Wright, I., Hilder, L., Abdel-Latif, M. E., Feng, X., Astell-Burt, T., Badland, H., Mavoa, S. & Giles-Corti, B. (2018). Somanathan, A. & Oei, J. (2018). Treatment with nitric oxide in the neonatal Modest ratios of fast food outlets to supermarkets and green grocers are intensive care unit is associated with increased risk of childhood cancer. Acta associated with higher body mass index: Longitudinal analysis of a sample Paediatrica, 107 (12), 2092-2098. of 15,229 Australians aged 45 years and older in the Australian National Liveability Study. Health and Place, 49 101-110. Dobson, J. A., Riddiford-Harland, D. L. & Steele, J. R. (2018). Effects of wearing gumboots and leather lace-up work boots on plantar loading when Fernandez, R., Sheppard-Law, S., Curtis, S., Bancroft, J. & Smith, W. walking on a simulated underground coal mine surface. Footwear Science, (2018). Exploring the experiences of neophyte nurse mentors: A qualitative 10 (3), 139-148. study. Nurse Education in Practice, 29 76-81.
Dobson, J. A., Riddiford-Harland, D. L., Bell, A. F. & Steele, J. R. (2018). Fernandez, R., Zaky, F., Ekmejian, A., Curtis, E. & Lee, A. (2018). Are underground coal miners satisfied with their work boots?. Applied Safety and efficacy of ulnar artery approach for percutaneous cardiac Ergonomics: human factors in technology and society, 66 98-104. catheterization: Systematic review and meta-analysis. Catheterization And Cardiovascular Interventions, 91 (7), 1273-1280. Dobson, J. A., Riddiford-Harland, D. L., Bell, A. F. & Steele, J. R. (2018). How do we fit underground coal mining work boots?. Ergonomics, 61 (11), Ferreira, I. (2018). Associations between blood pressure and arterial stiffness 1496-1506. with cognition: neuroaggression or neuroselection?. Journal of the American Heart Association, 7 (21), e010900-1-e010900-3. Dobson, J. A., Riddiford-Harland, D. L., Bell, A. F. & Steele, J. R. (2018). The three-dimensional shapes of underground coal miners’ feet do not match Ferreira, I., Hovind, P., Schalkwijk, C. G., Parving, H., Stehouwer, C. D. A. & the internal dimensions of their work boots. Ergonomics: an international Rossing, P. (2018). Biomarkers of inflammation and endothelial dysfunction as journal of research and practice in human factors and ergonomics, 61 (4), predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 588-602. year life-course study in an inception cohort. Diabetologia, 61 (1), 231-241.
Dodd, J. M., Deussen, A. R., O'Brien, C. M., Schoenaker, D. A. J. M., Fisher, A., Hammersley, M. L., Jones, R. A., Morgan, P. J., Collins, C. E. Poprzeczny, A., Gordon, A. & Phelan, S. (2018). Targeting the postpartum & Okely, A. (2018). Goal setting for weight-related behavior change in period to promote weight loss: a systematic review and meta-analysis. children: An exploratory study. Nutrition and Health, 24 (2), 67-74. Nutrition Reviews, 76 (8), 639-654. Forsyth, J. R., Riddiford-Harland, D. L., Whitting, J. W., Sheppard, J. M. & Dreyfus, S., Phillipson, L. & Fleming, R. (2018). Staff and family attitudes to Steele, J. R. (2018). Understanding successful and unsuccessful landings of fences as a means of detaining people with dementia in residential aged aerial maneuver variations in professional surfing. Scandinavian Journal of care settings: The tension between physical and emotional safety. Australian Medicine and Science in Sports, 28 (5), 1615-1624. Journal of Social Issues, 53 (2), 107-122. Forsyth, S., Calder, P. C., Zotor, F., Amuna, P., Meyer, B. & Holub, B. (2018). Duan, D., Xu, J., Feng, X., Astell-Burt, T., Xu, G., Lu, N., Li, H., Xu, G. & Dietary Docosahexaenoic Acid and Arachidonic Acid in Early Life: What Is the Han, L. (2018). Does body mass index and adult height influence cancer Best Evidence for Policymakers?. Annals of Nutrition and Metabolism: European incidence among Chinese living with incident type 2 diabetes?. Cancer journal of nutrition, metabolic diseases and dietetics, 72 (3), 210-222. Epidemiology: the international journal of cancer epidemiology, detection and prevention, 53 187-194. Francois, M. E., Gilbertson, N. M., Eichner, N. Z. M., Heiston, E. M., Fabris, C., Breton, M., Mehaffey, J. Hunter., Hassinger, T., Hallowell, Dune, T., Caputi, P. & Walker, B. (2018). A systematic review of mental P. T. & Malin, S. K. (2018). Combining short-term interval training with health care workers' constructions about culturally and linguistically diverse caloric restriction improves ß-cell function in obese adults. Nutrients, 10 people. PLoS One, 13 (7), 1-20. (6), 717-1-717-13.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 43 Francois, M. E., Myette-Cote, E., Bammert, T. D., Durrer, C., Neudorf, H., Hewitt, L., Benjamin-Neelon, S. E., Carson, V., Stanley, R. M., Janssen, DeSouza, C. A. & Little, J. P. (2018). Carbohydrate restriction with postmeal I. & Okely, A. D. (2018). Child care centre adherence to infant physical walking effectively mitigates postprandial hyperglycemia and improves activity and screen time recommendations in Australia, Canada and the endothelial function in type 2 diabetes. American Journal of Physiology — United States: An observational study. Infant Behavior and Development, Heart and Circulatory Physiology, 314 (1), H105-H113. 50 88-97.
Francois, M. E., Pistawka, K. J., Halperin, F. A. & Little, J. P. (2018). Hodgkins, A. Jose., Bonney, A., Mullan, J., Mayne, D. John. & Barnett, S. Cardiovascular benefits of combined interval training and post-exercise (2018). Survival analysis using primary care electronic health record data: A nutrition in type 2 diabetes. Journal of Diabetes and Its Complications, 32 systematic review of the literature. Health Information Management Journal, (2), 226-233. 47 (1), 6-16.
Frensham, L. J., Parfitt, G., Stanley, R. & Dollman, J. (2018). Perceived Hoffman, R. & Bonney, A. (2018). Junior doctors, burnout and wellbeing facilitators and barriers in response to a walking intervention in rural cancer Understanding the experience of burnout in general practice registrars and survivors: A qualitative exploration. International Journal of Environmental hospital equivalents. Australian Journal of General Practice, 47 (8), 571-575. Research and Public Health, 15 (12), 2824-1-2824-13. Horne, F., Burns, P., Traynor, V., Gillespie, R., Mullan, J., Baker, A., Fuller, S., Tapsell, L. C. & Beck, E. J. (2018). Creation of a fibre categories Harrison, L. & Win, K. Than. (2018). Managing medications for individuals database to quantify different dietary fibres. Journal of Food Composition and living with a dementia: Evaluating a web-based information resource for Analysis, 71 36-43. informal carers. International Journal of Older People Nursing, 13 (3), e12198-1-e12198-8. Gillespie, R. J., Harrison, L. & Mullan, J. (2018). Deprescribing medications for older adults in the primary care context: A mixed studies review. Health Houston, L., Probst, Y. & Martin, A. (2018). Assessing data quality and the Science Reports, 1 (7), e45-1-e45-13. variability of source data verification auditing methods in clinical research settings. Journal Of Biomedical Informatics, 83 25-32. Gillespie, R., Mullan, J. & Harrison, L. (2018). Deprescribing for older adults in Australia: Factors influencing GPs. Australian Journal of Primary Health, Houston, L., Probst, Y., Yu, P. & Martin, A. (2018). Exploring Data Quality 24(6) 463-469. Management within Clinical Trials. Applied Clinical Informatics - ACI, 9 (1), 72-81. Gordon, R., Butler, K., Cooper, P., Waitt, G. & Magee, C. (2018). Look before you LIEEP: Practicalities of using ecological systems social marketing to Howard, S. J., Vella, S. A. & Cliff, D. P. (2018). Children's sports improve thermal comfort. Journal of Social Marketing, 8 (1), 99-119. participation and self-regulation: Bi-directional longitudinal associations. Early Childhood Research Quarterly, 42 (1), 140-147. Grundy, L., Chess-Williams, R., Brierley, S. M., Mills, K., Moore, K. H., Mansfield, K., Rose-Meyer, R., Sellers, D. & Grundy, D. (2018). NKA Hu, M., Zheng, P., Xie, Y., Boz, Z., Yu, Y., Tang, R., Jones, A., Zheng, K. & enhances bladder-afferent mechanosensitivity via urothelial and detrusor Huang, X. (2018). Propionate protects haloperidol-induced neurite lesions activation. American Journal of Physiology: Renal Physiology, 315 (4), mediated by neuropeptide Y. Frontiers in Neuroscience, 12 (Oct), 743-1- F1174-F1185. 743-10.
Guan, V. X., Probst, Y. C., Neale, E. P., Batterham, M. J. & Tapsell, L. C. Hunt, T., Wilson, C. J., Caputi, P., Wilson, I. & Woodward, A. (2018). The (2018). Identifying usual food choices at meals in overweight and obese impact of caller gender on telephone crisis-helpline workers' interpretation of study volunteers: implications for dietary advice. The British Journal of suicidality in caller vignettes. International Journal of Environmental Research Nutrition: an international journal of nutritional science, 120 (4), 472-480. and Public Health, 15(4), 831.
Hadian, T., Mirghafourvand, M., Mohammad-Alizadeh- Charandabi, S., Hunt, T., Wilson, C. J., Woodward, A., Caputi, P. & Wilson, I. G. (2018). Ghanbari-Homayi, S., Nahaeii, J. & Meedya, S. (2018). The Effect of Intervention among Suicidal Men: Future Directions for Telephone Crisis Prenatal Home Visiting for Adolescent Mothers on Maternal and Neonatal Support Research. Frontiers in Public Health, 6 (1), 1-7. Outcomes: A Systematic Review and Meta-Analysis. International Journal of Pediatrics, 6 (1), 6945-6962. Hurley, D., Allen, M., Swann, C., Okely, A. & Vella, S. (2018). The Development, Pilot, and Process Evaluation of a Parent Mental Health Literacy Halcomb, E., Antoniou, C., Middleton, R. & Mackay, M. (2018). The Intervention Through Community Sports Clubs. Journal of Child and Family experiences of Australian undergraduate nursing students of a clinical Studies, 27 2149-2160. placement in Cambodia. Collegian: The Australian Journal of Nursing Practice, Scholarship and Research, 25 (3), 313-318. Isaac, L. M., Buggy, E., Sharma, A., Karberis, A., Maddock, K. M. & Weston, K. M. (2018). Enhancing hospital care of patients with cognitive Halcomb, E., Ashley, C., James, S. & Smyth, E. (2018). Employment impairment. International Journal of Health Care Quality Assurance, 31 (2), conditions of Australian primary health care nurses. Collegian: The Australian 173-186. Journal of Nursing Practice, Scholarship and Research, 25 (1), 65-71. Iyengar, M., Oinas-Kukkonen, H. & Win, K. (2018). Persuasive Halcomb, E., Smyth, E. & McInnes, S. (2018). Job satisfaction and career technology in biomedical informatics. Journal of Biomedical Informatics, intentions of registered nurses in primary health care: An integrative review. 85 136-137. BMC Family Practice, 19 136-1-136-14. J. Russell, A. Lechner, Q. Hanich, A. Delisle, B. Campbell & K. Charlton, Halcomb, E., Smyth, E., Moxham, L., Traynor, V. & Fernandez, R. (2018). (2018) 'Assessing food security using household consumption expenditure Bachelor of Nursing Honours Programs in Australia: current trends and key surveys (HCES): a scoping literature review' Public Health Nutrition, 21(12): challenges. Collegian: The Australian Journal of Nursing Practice, Scholarship 2200-2210. and Research, 25 (4), 429-434. Jacobs Jr, D. R., Petersen, K. S., Svendsen, K., Ros, E., Sloan, C. B., Steffen, Hazzard, E., Walton, K., McMahon, A., Milosavljevic, M. & Tapsell, L. L. M., Tapsell, L. C. & Kris-Etherton, P. M. (2018). Considerations to facilitate C. (2018). Nutrition-related hospital presentations and admissions among a US study that replicates PREDIMED. Metabolism: clinical and experimental, radiotherapy outpatients: a systematic literature review. Journal of Human 85 361-367. Nutrition and Dietetics, 31 (3), 357-369. Jelsma, J. G. M., Van Poppel, M. N. M., Smith, B. J., Cinnadaio, N., Henderson, J., Barnett, S., Ghosh, A., Pollack, A. J., Hodgkins, A., Win, Bauman, A., Tapsell, L., Cheung, N. & van der Ploeg, H. P. (2018). K., Miller, G. C. & Bonney, A. (2018). Validation of electronic medical Changing psychosocial determinants of physical activity and diet in women data: Identifying diabetes prevalence in general practice. Health Information with a history of gestational diabetes mellitus. Diabetes/Metabolism Management Journal, Jan; 48 (1): 3-11. Research and Reviews, 34 (1), e2942-1-e2942-9.
44 2018-2019 ANNUAL REPORT Kandasamy, Y., Rudd, D., Smith, R., Lumbers, E. R. & Wright, I. M. R. Li, Y., Wang, L., Feng, X., Zhang, M., Huang, Z., Deng, Q., Zhou, M., Astell- (2018). Extra uterine development of preterm kidneys. Pediatric Nephrology, Burt, T. & Wang, L. (2018). Geographical variations in hypertension prevalence, 33 (6), 1007-1012. awareness, treatment and control in China: Findings from a nationwide and provincially representative survey. Journal of Hypertension, 36 (1), 178-187. Kariippanon, K. E., Cliff, D. P., Lancaster, S. L., Okely, A. D. & Parrish, A. (2018). Perceived interplay between flexible learning spaces and teaching, Liu, B., Chen, X., Li, Y., Liu, H., Guo, S. & Yu, P. (2018). Effect of passive learning and student wellbeing. Learning Environments Research, 21 (3), finger exercises on grip strength and the ability to perform activities of daily 301-20. living for older people with dementia: a 12-week randomized controlled trial. Clinical Interventions in Aging, 2018 (13), 2169-2177. Keane, C., Magee, C. & Kelly, P. (2018). Trajectories of Psychological Distress in Australians Living in Urban Poverty: The Impact of Interpersonal Looman, M., Schoenaker, D. A. J. M., Soedamah-Muthu, S. S., Geelen, Trauma. Journal of Traumatic Stress, 31 (3), 362-372. A., Feskens, E. J. M. & Mishra, G. D. (2018). Pre-pregnancy dietary carbohydrate quantity and quality, and risk of developing gestational Kennedy, S. G., Smith, J. J., Morgan, P. J., Peralta, L. R., Hilland, T. A., diabetes: The Australian Longitudinal Study on Women's Health. British Eather, N., Lonsdale, C., Okely, A. D., Plotnikoff, R. C., Salmon, J., Journal of Nutrition, 120 (4), 435-444. Dewar, D. L., Estabrooks, P. A., Pollock, E., Finn, T. L. & Lubans, D. R. (2018). Implementing Resistance Training in Secondary Schools: A Cluster M. Ghahramani, F. Naghdy, D. Stirling, G. Naghdy, J. Potter & M. Roach, Randomized Controlled Trial. Medicine and Science in Sports and Exercise, “Assessing the Risk of Fall in Older People through Turning Test,” in 2018 50 (1), 62-72. IEEE International Symposium on Medical Measurements and Applications, Proceedings: MeMeA, 2018, pp. 1-6. Kent, K. & Charlton, K. E. (2018). Development, validation and reproducibility of a food frequency questionnaire to measure flavonoid intake Mackay, M., Stephens, M., Wragg, S., Ebejer, S. & Bourgeois, S. (2018). in older Australian adults. Nutrition & Dietetics, 75 (1), 106-116. Empowering clinical supervisors to flourish though critical companionship. Nurse Education in Practice, 28 212-217. Kent, K., Charlton, K. E., Lee, S., Mond, J., Russell, J., Mitchell, P. & Flood, V. M. (2018). Dietary flavonoid intake in older adults: How many days MacMillan, F., George, E. S., Feng, X., Merom, D., Bennie, A., Cook, A., of dietary assessment are required and what is the impact of seasonality?. Sanders, T., Dwyer, G., Pang, B., Guagliano, J. M., Kolt, G. S. & Astell-Burt, T. Nutrition Journal, 17 (1), 1-9. (2018). Do natural experiments of changes in neighborhood built environment impact physical activity and diet? A systematic review. International Journal of Khunkaew, S., Tungpunkom, P., Sim, J. & Fernandez, R. (2018). The Environmental Research and Public Health, 15 (2), 217-1-217-29. Experiences of people in Northern Thailand living with Diabetic Foot Ulcers: A descriptive qualitative study. Pacific Rim International Journal of Nursing Magee, C. A., Robinson, L. D. & McGregor, A. (2018). The Work-Family Research, 22 (4), 304-318. Interface and Sleep Quality. Behavioral Sleep Medicine, 16 (6), 601-610.
L. Phillipson, D. Hall, E. Cridland, R. Fleming, C. Brennan-Horley, N. Mares, M. A., McNally, S. & Fernandez, R. S. (2018). Effectiveness of Guggisberg, D. Frost & H. Hasan, Involvement of people with dementia in nurse-led cardiac rehabilitation programs following coronary artery bypass raising awareness and changing attitudes in a dementia friendly community graft surgery: a systematic review. The JBI Database of Systematic Reviews pilot project. Dementia, 18 (7-8), 2576-2595 and Implementation Reports, 16 (12), 2304-2329.
Lambert, K., Mansfield, K. & Mullan, J. (2018). How do patients and carers Maunder, K., Walton, K., Williams, P., Ferguson, M. & Beck, E. (2018). A make sense of renal dietary advice? A qualitative exploration. Journal of framework for eHealth readiness of dietitians. International Journal of Medical Renal Care, 44 (4), 238-250. Informatics, 115 43-52.
Lambert, K., Mansfield, K. & Mullan, J. (2018). Qualitative exploration of Maunder, K., Walton, K., Williams, P., Ferguson, M. & Beck, E. (2018). eHealth the experiences of renal dietitians and how they help patients with end stage readiness of dietitians. Journal of Human Nutrition and Dietetics, 31 (4), 573-583. kidney disease to understand the renal diet. Nutrition and Dietetics, 76: 126-134 Maunder, K., Walton, K., Williams, P., Ferguson, M. & Beck, E. (2018). Strategic leadership will be essential for dietitian eHealth readiness: A Lapkin, S. & Fernandez, R. (2018). Confirmatory Factor Analysis and qualitative study exploring dietitian perspectives of eHealth readiness. Psychometric Properties of the Multidimensional Acculturative Stress Scale. Nutrition and Dietetics, 76(4), 373-381 Australian Psychologist, 53 (4), 339-344. Mavilidi, M., Okely, A., Chandler, P., Louise Domazet, S. & Paas, F. Lapkin, S., Levido, D., Palesy, D., Mamo, A., Perez, M., Dutchak, D. & (2018). Immediate and delayed effects of integrating physical activity into Fernandez, R. (2018). What's the plan?: Supporting individualised care for preschool children's learning of numeracy skills. Journal of Experimental Child hospitalised patients with stomas. Journal of Stomal Therapy Australia, 38 (2), Psychology, 166 502-519. 12-18. Mavilidi, M., Ruiter, M., Schmidt, M., Okely, A. D., Loyens, S., Chandler, Larkin, T. A., Ashcroft, E., Hickey, B. A. & Elgellaie, A. (2018). Influence P. & Paas, F. (2018). A narrative review of school-based physical activity of gender, BMI and body shape on theoretical injection outcome at the for enhancing cognition and learning: The importance of relevancy and ventrogluteal and dorsogluteal sites. Journal of Clinical Nursing, 27 (1-2), integration. Frontiers in Psychology, 9 2079-1-2079-17. e242-e250. Mayne, D. J., Morgan, G. G., Jalaludin, B. B. & Bauman, A. E. (2018). Larkin, T. A., Elgellaie, A. & Ashcroft, E. (2018). Comparison of Does walkability contribute to geographic variation in psychosocial distress? the G and V methods for ventrogluteal site identification: Muscle A spatial analysis of 91,142 members of the 45 and up study in Sydney, and subcutaneous fat thicknesses and considerations for successful Australia. International Journal of Environmental Research and Public Health, intramuscular injection. International Journal of Mental Health Nursing, 27 15 (2), 1-24. (2), 631-641. McGhee, D. E., Coltman, K. A., Riddiford-Harland, D. L. & Steele, J. R. Levi, R., Probst, Y., Crino, M. & Dunford, E. (2018). Evaluation of Australian (2018). Upper torso pain and musculoskeletal structure and function in soup manufacturer compliance with national sodium reduction targets. women with and without large breasts: A cross sectional study. Clinical Nutrition and Dietetics, 75 (2), 200-205. Biomechanics, 51 99-104.
Lewis, M. C., Peoples, G. E., Groeller, H. & Brown, M. A. (2018). McGhee, D. E., Ramsay, L. G., Coltman, C. E., Gho, S. A. & Steele, J. Eccentric cycling emphasising a low cardiopulmonary demand increases R. (2018). Bra band size measurements derived from three-dimensional leg strength equivalent to workload matched concentric cycling in middle scans are not accurate in women with large, ptotic breasts. Ergonomics: age sedentary males. Journal of Science and Medicine in Sport, 21 (12), an international journal of research and practice in human factors and 1238-1243. ergonomics, 61 (3), 464-472.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 45 McGregor, A., Ashbury, F., Caputi, P. & Iverson, D. (2018). A Preliminary Okely, A. D. & Hammersley, M. L. (2018). School-home partnerships: Investigation of Health and Work-Environment Factors on Presenteeism in the the missing piece in obesity prevention?. The Lancet Child and Adolescent Workplace. Journal of Occupational and Environmental Medicine, 60 (12), Health, 2 (1), 5-6. e671-e678. Okely, A. D., Batterham, M. J., Hinkley, T., Ekelund, U., Brage, S., Reilly, McGregor, A., Sharma, R., Magee, C., Caputi, P. & Iverson, D. J. J., Trost, S. G., Jones, R. A., Janssen, X., Cliff, D. P. & van Loo, C. Maria (2018). Explaining Variations in the Findings of Presenteeism Research: Theodora. (2018). Wrist Acceleration Cut Points for Moderate-to-Vigorous A Meta-Analytic Investigation Into the Moderating Effects of Construct Physical Activity in Youth. Medicine And Science In Sports And Exercise, 50 Operationalizations and Chronic Health. Journal Of Occupational Health (3), 609-616. Psychology, 23 (4), 584-601. Okely, A. D., Tremblay, M. S., Hammersley, M. & Aubert, S. (2018). McInnes, S., Halcomb, L., Patterson, C. & Moxham, L. (2018). Exploring Targeting Sedentary Behaviour at the Policy Level. In M. F. Leitzmann, C. the General Practice Nurse's Role in Delivering Primary Mental Health Care. Jochem & D. Schmid (Eds.), Sedentary Behaviour Epidemiology (pp. 565- Australian Primary Health Care Nurses Association National Conference 594). Netherlands: Springer International Publishing AG. 2018 ‘Nurseforce for the Future’ Okely, A. D., Tremblay, M. S., Reilly, J. J., Draper, C. E. & Bull, F. (2018). McNeill, J., Howard, S. J., Vella, S. A., Santos, R. & Cliff, D. P. (2018). Physical activity, sedentary behaviour, and sleep: movement behaviours in Physical activity and modified organized sport among preschool children: early life. The Lancet Child and Adolescent Health, 2 (4), 233-235. Associations with cognitive and psychosocial health. Mental Health and Physical Activity, 15 45-52. Olsen, P., Williamson, M., Traynor, V. & Georgiou, C. (2018). The impact of oral probiotics on vaginal Group B Streptococcal colonisation rates in Meyerowitz-Katz, G., Bramwell, S., Jayaballa, R., Bishay, R., Corless, I., pregnant women: A pilot randomised control study. Women and Birth, 31 Ravi, S., Soars, L., Feng, X., Astell-Burt, T., Manoharan, M., McLean, M. (1), 31-37. & Maberly, G. (2018). Effectiveness of joint specialist case conferences for building general practice capacity to enhance diabetes care: A pilot study in Onyiaodike, C. C., Murray, H. M., Zhang, R., Meyer, B. J., Jordan, F., Western Sydney, Australia. Journal Of Integrated Care, 26 (3), 199-210. Brown, E. Ann., Nibbs, R. J. B., Lyall, H., Sattar, N., Nelson, S. M. & Freeman, D. J. (2018). Pre-conception maternal erythrocyte saturated to Middleton, R., Mackay, M., Riley, K. & Stephens, M. (2018). A creation unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen story of leadership development. International Practice Development Journal, embryo transfer. Scientific Reports, 8 (1), 1216-1-1216-8. 8 (1), 1-8. Owen, K. B., Parker, P. D., Astell-Burt, T. & Lonsdale, C. (2018). Effects of Mitchell, H., Lucas, C., Charlton, K. & McMahon, A. (2018). Models of physical activity and breaks on mathematics engagement in adolescents. nutrition-focused continuing education programs for nurses: A systematic review Journal of Science and Medicine in Sport, 21 (1), 63-68. of the evidence. Australian Journal of Primary Health, 24 (2), 101-108. Owen, K. B., Parker, P. D., Astell-Burt, T. & Lonsdale, C. (2018). Regular Monjo, F., Shemmell, J. & Forestier, N. (2018). The sensory origin of the Physical Activity and Educational Outcomes in Youth: A Longitudinal Study. sense of effort is context-dependent. Experimental Brain Research, 236 (7), Journal of Adolescent Health, 62 (3), 334-340. 1997-2008. Pai, N., Westley-Wise, V., Lago, L., Facci, F., Zingel, R., Mullan, J. & Eagar, Montgomery, A., Riley, T., Tranter, S., Manning, V. & Fernandez, R. S. K. (2018). Trends and patterns in unplanned readmissions to ISLHD hospitals (2018). Effect of an evidence based quality improvement framework on following admissions for mental diseases and disorders. Australian and New patient safety. Australian Journal of Advanced Nursing, 35 (4), 6-16. Zealand Journal of Psychiatry, 53 (S1), 103.
Moxham, L. Jane., Fernandez, R., Kim, B., Lapkin, S., ten Ham-Baloyi, Palermo, C., Dart, J., Begley, A., Beck, E. J., Bacon, R., Tweedie, J., W. & Al Mutair, A. (2018). Employment as a predictor of mental health, Mitchell, L., Maher, J., Gallegos, D., Kennedy, M., Kellett, J., Margerison, psychological distress, anxiety and depression in Australian pre-registration C., Crawford, R., Stuart-Smith, W. et al (2018). Dietetics students’ nursing students. Journal of Professional Nursing, 34(6), 502-506. construction of competence through assessment and placement experiences. Nutrition and Dietetics, 75 (3), 307-315. Mullan, J., Burns, P. & Sargeant, D. (2018). Caregivers' knowledge about children's paracetamol. Journal of Pharmacy Practice and Research, 48 (5), Palermo, C., Volders, E., Gibson, S., Kennedy, M., Wray, A., Thomas, J., 454-458. Hannan-Jones, M., Gallegos, D. & Beck, E. (2018). Exploring approaches to dietetic assessment of a common task across different universities through Mullan, J., Burns, P., Weston, K., Crowther, S., Dixon, R. & Moselen, E. assessment moderation. Journal of Human Nutrition and Dietetics, 31 (1), 41-46. (2018). What do Australian & New Zealand caregivers know about children's ibuprofen? The results of an online survey?. BMC Pediatrics, 18 Parker, R., Larkin, T. A. & Cockburn, J. P. “Gender Bias in Medical Images (1), 327-1-327-4. Affects Students’ Implicit but not Explicit Gender Attitudes.” AERA Open 4 .3 (2018): 1-7. Nagy, A., McMahon, A., Tapsell, L., Deane, F. & Arenson, D. (2018). Therapeutic alliance in dietetic practice for weight loss: Insights from health Parrish, A., Trost, S. G., Howard, S. J., Batterham, M., Cliff, D., Salmon, J. & coaching. Nutrition and Dietetics, 75 (3), 250-255. Okely, A. D. (2018). Evaluation of an intervention to reduce adolescent sitting time during the school day: The ‘Stand Up for Health’ randomised controlled Ndanuko, R. N., Tapsell, L. C., Charlton, K. E., Neale, E. P. & Batterham, trial. Journal of Science and Medicine in Sport, 21 (12), 1244-1249. M. J. (2018). Effect of individualised dietary advice for weight loss supplemented with walnuts on blood pressure: the HealthTrack study. Pearson, R., Mullan, J., Ujvary, E., Bonney, A. & Dijkmans-Hadley, European Journal of Clinical Nutrition, 1758 129-138. B. (2018). Australian general practitioner attitudes to residential aged care facility visiting. Health and Social Care in the Community, 26 (4), Ng, S., Swinburn, B., Kelly , B., Vandevijvere, S., Yeatman, H., Ismail, M. e497-e504. Noor. & Karupaiah, T. (2018). Extent of implementation of food environment policies by the Malaysian Government: Gaps and priority recommendations. Peden, M. E., Okely, A. D., Eady, M. J. & Jones, R. A. (2018). What is Public Health Nutrition, 21 (18), 3395-3406. the impact of professional learning on physical activity interventions among preschool children? A systematic review. Clinical Obesity, 8 (4), 285-299. Oei, J., Finer, N. N., Saugstad, O. Didrik., Wright, I. M., Rabi, Y., Tarnow- Mordi, W., Rich, W., Kapadia, V., Rook, D., Smyth, J. P., Lui, K. & Vento, Prangley, T., Pit, S. Winona., Rees, T. & Nealon, J. (2018). Factors M. (2018). Outcomes of oxygen saturation targeting during delivery room influencing early withdrawal from a drug and alcohol treatment program and stabilisation of preterm infants. Archives Of Disease In Childhood-fetal And client perceptions of successful recovery and employment: A qualitative study. Neonatal Edition, 103 (5), F446-F454. BMC Psychiatry, 18 (1), 301-1-301-11.
46 2018-2019 ANNUAL REPORT Probst, Y., Guan, V. & Kent, K. (2018). A systematic review of food Sun, J. & Fleming, R. (2018). Characteristics of the built environment for composition tools used for determining dietary polyphenol intake in estimated people with dementia in East and Southeast Asian nursing homes: a scoping intake studies. Food Chemistry, 238 146-152. review. International Psychogeriatrics, 30 (4), 469-480.
Qian, S., Yu, P., Hailey, D., Wang, N. & Bhattacherjee, A. (2018). Suthers, R., Broom, M. & Beck, E. J. (2018). Key Characteristics of Public Medication administration process in a residential aged care home: An Health Interventions Aimed at Increasing Whole Grain Intake: A Systematic observational study. Journal of Nursing Management, 26 (8), 1033-1043. Review. Journal of Nutrition Education and Behavior, 50 (8), 813-823.
Quinlan, E., Deane, F., Crowe, T. & Caputi, P. (2018). Do attachment Tanywe, A., Matchawe, C., Fernandez, R. & Lapkin, S. (2018). Experiences anxiety and hostility mediate the relationship between experiential avoidance of women living with infertility in Africa: a qualitative systematic review and interpersonal problems in mental health carers?. Journal of Contextual protocol. The JBI Database of Systematic Reviews and Implementation Behavioral Science, 7 63-71. Reports, 16 (9), 1772-1778.
Robinson, K., Lucas, E., van den Dolder, P. & Halcomb, E. (2018). Living Tanywe, A., Matchawe, C., Fernandez, R. & Lapkin, S. (2018). Perceptions with chronic obstructive pulmonary disease: the stories of frequent attenders of blood donation among people in Africa: a qualitative systematic review to the Emergency Department. Journal of Clinical Nursing, 27 (1-2), 48-56. protocol. The JBI Database of Systematic Reviews and Implementation Reports, 16 (3), 648-652. Sattler, K., Deane, F., Tapsell, L. & Kelly, P. (2018). Gender differences in the relationship of weight-based stigmatisation with motivation to exercise and Tartarini, F., Cooper, P. & Fleming, R. (2018). Thermal Comfort for physical activity in overweight individuals. Health Psychology Open, 5 (1), 1-11. Occupants of Nursing Homes: A Field Study. In L. Brotas, S. Roaf, F. Nicol & M. Humphreys (Eds.), Rethinking Comfort: The Tenth Windsor Conference Schoenaker, D., Vergouwe, Y., Soedamah-Muthu, S. S., Callaway, L. (pp. 720-737). Network for Comfort and Energy Use in Buildings. K. & Mishra, G. D. (2018). Preconception risk of gestational diabetes: Development of a prediction model in nulliparous Australian women. Tartarini, F., Cooper, P. & Fleming, R. (2018). Thermal perceptions, Diabetes Research and Clinical Practice, 146 48-57. preferences and adaptive behaviours of occupants of nursing homes. Building and Environment, 132 57-69. Shukla, N., Hagenbuchner, M., Win, K. & Yang, J. (2018). Breast cancer data analysis for survivability studies and prediction. Computer Methods and Thamrin, V., Saugstad, O. D., Tarnow-Mordi, W., Wang, Y., Lui, Programs in Biomedicine, 155 199-208. K., Wright, I. M., de Waal, K., Travadi, J., Smyth, J. P., Craven, P., McMullan, R., Coates, E., Ward, M., Mishra, P., See, K. Ching., Cheah, Sim, J., Crookes, P., Walsh, K. & Halcomb, E. (2018). Measuring the I. G. S., Lim, C. Theam., Choo, Y. Mun., Kamar, A. Ahmad., Cheah, outcomes of nursing practice: A Delphi study. Journal of Clinical Nursing, 27 F. Choe., Masoud, A. & Oei, J. (2018). Preterm Infant Outcomes after (1-2), e368-e378. Randomization to Initial Resuscitation with FiO(2) 0.21 or 1.0. Journal of Pediatrics, 201 55-61.e1. Siraj, I., Melhuish, E., Howard, S., Neilsen-Hewett, C., Kingston, D., de Rosnay, M., Duursma, E., Feng, X. & Luu, B. (2018). Fostering Effective Early Thomas, S. & Larkin, T. (2018). Plasma cortisol and oxytocin levels predict Learning (FEEL) Study: Final Report. Sydney, Australia: NSW Department help-seeking intentions for depressive symptoms. Psychoneuroendocrinology, of Education. https://education.nsw.gov.au/early-childhood-education/ 87 159-165. whats-happening-in-the-early-childhood-education-sector/data-and-research/ feel-study-2018 Trakis, S., Fernandez, R. & Parrish, D. (2018). Demographic predictors of emotional intelligence among radiation therapists. Journal of Medical Sparkes, C., Gibson, R., Sinclair, A., Else, P. L. & Meyer, B. J. (2018). Radiation Sciences, Jun; 65(2): 114-122. Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose-Response Randomized Traynor, V., Veerhuis, N., Johnson, K., Hazelton, J. & Gopalan, S. (2018). Placebo-Controlled Trial. Nutrients, 10 (10), 1460-1-1460-17. Evaluating the effects of a physical activity on agitation and wandering (PAAW) experienced by individuals living with a dementia in care homes. Stanford, L., Bonney, A., Mullan, J. & Dijkmans-Hadley, B. (2018). The role Journal of Research in Nursing, 23 (2-3), 125-138. of chaperones: How involved is too involved?. Australian Journal of General Practice, 47 (3), 87-89. Trost, S. G., Cliff, D. P., Ahmadi, M. N., Tuc, N. Van. & Hagenbuchner, M. (2018). Sensor-enabled Activity Class Recognition in Preschoolers: Hip Stephen, C. M., Hermiz, O. S., Halcomb, E. J., McInnes, S. & Zwar, N. versus Wrist Data. Medicine And Science In Sports And Exercise, 50 (3), (2018). Feasibility and acceptability of a nurse-led hypertension management 634-641. intervention in general practice. Collegian: The Australian Journal of Nursing Practice, Scholarship and Research, 25 (1), 33-38. Tsai, C., Svensen, E., Flood, V. M., Probst, Y., Reilly, K., Corbett, S. & Wu, J. H. Y. (2018). Healthiness of food and beverages for sale at two Stephen, C., McInnes, S. & Halcomb, E. (2018). The feasibility and public hospitals in New South Wales, Australia. Nutrients, 10 (2), 216- acceptability of nurse-led chronic disease management interventions in primary 1-216-13. care: An integrative review. Journal of Advanced Nursing, 74 (2), 279-288. Veldman, S. L. C., Jones, R. A., Santos, R., Sousa- Sa, E., Pereira, J. R., Stephens, M., Halcomb, E. J. & Dewing, J. (2018). Living on: an exploration Zhang, Z. & Okely, A. D. (2018). Associations between gross motor skills of healthful cancer survivorship among grey. The Australian Journal of Cancer and physical activity in Australian toddlers. Journal of Science and Medicine Nursing, 19 (1), 19-24. in Sport, 21 (8), 817-821.
Stephenson, J., Heslehurst, N., Hall, J., Schoenaker, D. A. J. M., Hutchinson, Veldman, S. L.C., Jones, R. A., Santos, R., Sousa-Sá, E. & Okely, A. D. J., Cade, J. E., Poston, L., Barrett, G., Crozier, S. R., Barker, M., Kumaran, (2018). Gross motor skills in toddlers: Prevalence and socio-demographic K., Yajnik, C. S., Baird, J. & Mishra, G. D. (2018). Before the beginning: differences. Journal of Science and Medicine in Sport, 21 (12), 1226- nutrition and lifestyle in the preconception period and its importance for future 1231. health. The Lancet, 391 (10132), 1830-1841. Veldman, S. L.C., Santos, R., Jones, R. A., De Sousa-Sa, E. & Okely, A. D. Strooband, K., Stanley, R., Okely, A. & Jones, R. (2018). Support to (2018). Associations between gross motor skills and cognitive development enhance level of implementation in physical activity interventions: An in Australian toddlers. Journal of Sport and Exercise Psychology, 40 observational study. Australasian Journal of Early Childhood, 43 (1), 25-33. S38-S38.
Stuetzle, K. V., Pavlin, B. I., Smith, N. A. & Weston, K. M. (2018). Survey Vella, S. A. & Cliff, D. P. (2018). Organised sports participation and of occupational fatigue in anaesthetists in Australia and New Zealand. adiposity among a cohort of adolescents over a two year period. PLoS One, Anaesthesia And Intensive Care, 46 (4), 414-423. 13 (12), e0206500-1-e0206500-11.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 47 Vella, S., Swann, C., Batterham, M., Boydell, K., Eckermann, S., Fogarty, Wilson, A., Vento, M., Shah, P., Saugstad, O., Finer, N., Rich, W., Morton, A., Hurley, D., Liddle, S., Lonsdale, C., Miller, A., Noetel, M., Okely, A., R. L., Rabi, Y., Tarnow-Mordi, W., Suzuki, K., Wright, I. M. & Oei, J. L. Sanders, T., Telenta, J. & Deane, F. (2018). Ahead of the game protocol: (2018). A review of international clinical practice guidelines for the use of A multi-component, community sport-based program targeting prevention, oxygen in the delivery room resuscitation of preterm infants. Acta Paediatrica: promotion and early intervention for mental health among adolescent males. promoting child health, 107 (1), 20-27. BMC Public Health, 18 (1), 390-402. Woon, F., Chin, Y., Ismail, I., Chan, Y., Batterham, M., Abdul, A., Gan, W. Veno, S. K., Bork, C. S., Jakobsen, M. U., Lundbye-Christensen, S., Bach, & Appannah, G. (2018). Contribution of early nutrition on the development F. W., McLennan, P. L., Tjonneland, A., Schmidt, E. B. & Overvad, K. of malnutrition and allergic diseases in the first year of life: A study protocol (2018). Substitution of fish for red meat or poultry and risk of ischemic stroke. for the Mother and Infant Cohort Study (MICOS). BMC Pediatrics, 18 (1), Nutrients, 10 (11), 1648-1-1648-11. 233-1-233-9.
Vlahu-Gjorgievska, E., Mulakaparambil Unnikrishnan, S. & Win, K. Than. Wu, Y., Huang, X., Bell, C. & Yu, Y. (2018). Ginsenoside Rb1 improves (2018). mHealth Applications: A Tool for Behaviour Change in Weight leptin sensitivity in the prefrontal cortex in obese mice. CNS Neuroscience Management. Studies in Health Technology and Informatics, 252 158-163. and Therapeutics, 24 (2), 98-107. Sydney, Australia Connecting the System to Enhance the Practitioner and Consumer Experience in Healthcare Yu, P. & Qian, S. (2018). Developing a theoretical model and questionnaire survey instrument to measure the success of electronic health records in Vlahu-Gjorgievska, E., Win, K. & Susilo, W. (2018). A System Model for residential aged care. PLoS One, 13 1-18. Personalized Medication Management (MyMediMan) - The Consumers' Point of View. Information, 9 (4), 1-10. Yu, Y., Patch, C., Weston-Green, K., Zhou, Y., Zheng, K. & Huang, X. (2018). Dietary Galacto-Oligosaccharides and Resistant Starch Protect Wales, K., Salkeld, G., Clemson, L., Lannin, N. A., Gitlin, L., Rubenstein, Against Altered CB1 and 5-HT1A and 2A Receptor Densities in Rat Brain: L., Howard, K., Howell, M. & Cameron, I. D. (2018). A cost minimization Implications for Preventing Cognitive and Appetite Dysfunction During a analysis of occupational therapy discharge planning for older adults: the High-Fat Diet. Molecular Nutrition and Food Research, 62 (21), 1800422- HOME randomized controlled trial. Clinical Rehabilitation, 32 (7), 919-929. 1-1800422-9.
Wales, K., Salkeld, G., Clemson, L., Lannin, N. A., Gitlin, L., Rubenstein, L., Zhang, J., Feng, X., Zhai, Y., Li, W., Lv, Y., Astell-Burt, T. & Shi, X. (2018). Howard, K., Howell, M. & Cameron, I. D. (2018). A trial based economic Clustering of unhealthy lifestyle behaviours and associations with perceived evaluation of occupational therapy discharge planning for older adults: the and actual weight status among primary school children in China: A nationally HOME randomized trial. Clinical Rehabilitation, 32 (7), 919-929. representative cross-sectional study. Preventive Medicine, 112 6-14.
Walsan, R., Bonney, A., Mayne, D. J., Pai, N., Feng, X. & Toms, R. (2018). Zhang, J., Zhai, Y., Feng, X., Li, W., Lyu, Y., Astell-Burt, T., Zhao, P. & Serious Mental Illness, Neighborhood Disadvantage, and Type 2 Diabetes Shi, X. (2018). Gender Differences in the Prevalence of Overweight and Risk: A Systematic Review of the Literature. Journal of Primary Care and Obesity, Associated Behaviors, and Weight-related Perceptions in a National Community Health, 9 1-7. Survey of Primary School Children in China. Biomedical and Environmental Sciences, 31 (1), 1-11. Walter, E., Fernandez, F., Snelling, M. & Barkus, E. (2018). Stress induced cortisol release and schizotypy. Psychoneuroendocrinology, 89 209-215. Zhang, Y., You, D., Lu, N., Duan, D., Feng, X., Astell-Burt, T., Zhu, P., Han, L., Duan, S. & Zou, Z. (2018). Potatoes consumption and risk of type 2 diabetes: Ward, H., Chiavaroli, N., Fraser, J., Mansfield, K., Starmer, D., Surmon, L., A meta-analysis. Iranian Journal of Public Health, 47 (11), 1627-1635. Veysey, M. & O'Mara, D. (2018). Standard setting in Australian medical schools. BMC Medical Education, 18 (1), 80-1-80-20. Zhang, Z., Pereira, J. R., Sousa-Sa, E., Okely, A. D., Feng, X. & Santos, R. (2018). Environmental characteristics of early childhood education and care Waters, E., Gibbs, L., Tadic, M., Ukoumunne, O. C., Magarey, A., centres and young children's weight status: A systematic review. Preventive Okely, A. D., de Silva, A., Armit, C., Green, J., O'Connor, T., Johnson, B., Medicine, 106 13-25. Swinburn, B., Carpenter, L., Moore, G., Littlecott, H. & Gold, L. (2018). Cluster randomised trial of a school-community child health promotion and Zhang, Z., Pereira, J. R., Sousa-Sa, E., Okely, A. D., Feng, X. & Santos, R. obesity prevention intervention: Findings from the evaluation of fun 'n healthy (2018). Environmental characteristics of early childhood education and care, in Moreland!. BMC Public Health, 18 (1), 92-1-92-16. daily movement behaviours and adiposity in toddlers: A multilevel mediation analysis from the GET UP! Study. Health and Place, 54 236-243. Weston, K. M., Garne, D. L., Bushnell, J. A. & Hudson, J. N. (2018). The big city by-pass: Origin is important in medical students' preference for future practice in regional cities and large towns. Focus On Health Professional Education — a Multidisciplinary Journal, 19 (1), 12-24.
Weston, K. M., McCarthy, L. R., Meyering, I. Barrett., Hampton, S. & Mackinnon, T. (2018). Health behind bars: can exploring the history of prison health systems impact future policy?. Journal of Clinical Forensic and Legal Medicine: an international journal of forensic and legal medicine, 54 50-52.
Weston, K., Mullan, J., Rich, W. & McLennan, P. (2018). Medical Student Research during a Longitudinal Community-Based Placement Can Provide Opportunities for Learning about Public Health. Education Sciences, 8 (2), 60-1-60-10.
White, R. L., Olson, R., Parker, P. D., Astell-Burt, T. & Lonsdale, C. (2018). A qualitative investigation of the perceived influence of adolescents' motivation on relationships between domain-specific physical activity and positive and negative affect. Mental Health and Physical Activity, 14 113-120.
White, R. Lee., Parker, P. D., Lubans, D. R., MacMillan, F., Olson, R., Astell-Burt, T. & Lonsdale, C. (2018). Domain-specific physical activity and affective wellbeing among adolescents: an observational study of the moderating roles of autonomous and controlled motivation. International Journal of Behavioral Nutrition and Physical Activity, 15 87-1-87-13.
48 2018-2019 ANNUAL REPORT Diagnostics and therapeutics Belfiore, L., Spenkelink, L. M., Ranson, M., van Oijen, A. M. & Vine, K. L. (2018). Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging. Journal of Controlled A. Vial, D. Stirling, M. Field, M. Ros, C. Ritz, M. Carolan, L. Holloway Release, 278 80-86. & A. A. Miller, "The role of deep learning and radiomic feature extraction in cancer-specific predictive modelling: A review," Translational Cancer Berghuis, B. A., Raducanu, V., Elshenawy, M. M., Jergic, S., Depken, M., Research, vol. 7, (3) pp. 803-816, 2018. Dixon, N. E., Hamdan, S. M. & Dekker, N. H. (2018). What is all this fuss about Tus? Comparison of recent findings from biophysical and biochemical Abbas-Mohammadi, M., Moridi Farimani, M., Salehi, P., Nejad Ebrahimi, experiments. Critical Reviews in Biochemistry and Molecular Biology, 53 (1), S., Sonboli, A., Kelso, C. & Skropeta, D. (2018). Acetylcholinesterase- 49-63. inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the Biasi, G., Davis, J., Petasecca, M., Guatelli, S., Perevertaylo, V., Kron, T. & dereplication of active compounds. Journal of Pharmaceutical and Rosenfeld, A. B. (2018). On monolithic silicon array detectors for small-field Biomedical Analysis, 158 471-479. photon beam dosimetry. IEEE Transactions on Nuclear Science, 65 (9), 2640-2649. Alabd, R., Safavi-Naeini, M., Wilson, K. J., Rosenfeld, A. B. & Franklin, D. R. (2018). A simulation study of BrachyShade, a shadow-based internal Biasi, G., Petasecca, M., Guatelli, S., Ebert, M. A., Grogan, G., Hug, B., source tracking system for HDR prostate brachytherapy. Physics in Medicine Lane, J., Perevertaylo, V., Kron, T. & Rosenfeld, A. B. (2018). CyberKnife® and Biology, 63 (20), 205019-1-205019-15. fixed cone and Iris-defined small radiation fields: Assessment with a high- resolution solid-state detector array. Journal of Applied Clinical Medical Alnaghy, S. J., Begg, J., Causer, T., Alharthi, T., Glaubes, L., Dong, B., Physics, 19 (5), 547-557. George, A., Holloway, L. & Metcalfe, P. (2018). Technical Note: Penumbral width trimming in solid lung dose profiles for 0.9 and 1.5 T MRI-Linac Biasi, G., Petasecca, M., Guatelli, S., Hardcastle, N., Carolan, M., prototypes. Medical Physics, 45 (1), 479-487. Perevertaylo, V., Kron, T. & Rosenfeld, A. B. (2018). A novel high-resolution 2D silicon array detector for small field dosimetry with FFF photon beams. Al-Rahbi, Z. S., Cutajar, D. L., Metcalfe, P. & Rosenfeld, A. B. (2018). Physica Medica: an international journal devoted to the applications of Dosimetric effects of brass mesh bolus on skin dose and dose at depth for physics to medicine and biology, 45 117-126. postmastectomy chest wall irradiation. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 54 84-93. Bogusz, K., Cardillo, D., Tehei, M., Boutard, T., Barker, P. J., Devers, T., Rosenfeld, A., Dou, S. X., Liu, H. K. & Konstantinov, K. (2018). Biocompatible Al Shukaili, K., Corde, S., Petasecca, M., Pereveratylo, V., Lerch, M., Bi(OH)3nanoparticles with reduced photocatalytic activityas possible ultraviolet Jackson, M. & Rosenfeld, A. (2018). "Characterization of ELEKTA SRS cone filter in sunscreens. Materials Research Bulletin, 108 130-141. collimator using high spatial resolution monolithic silicon detector array". Journal of Applied Clinical Medical Physics, 19 (4), 114-124. Bogusz, K., Tehei, M., Cardillo, D., Lerch, M., Rosenfeld, A., Dou, S., Liu, H. & Konstantinov, K. (2018). High toxicity of Bi(OH)3 and a-Bi2O3 Apollo, N. V., Jiang, J., Cheung, W., Baquier, S., Lai, A., Mirebedini, A., nanoparticles towards malignant 9L and MCF-7 cells. Materials Science and Foroughi, J., Wallace, G. G., Shivdasani, M. N., Prawer, S., Chen, S., Engineering C: Materials for Biological Applications, 93 958-967. Williams, R., Cook, M. J., Nayagam, D. A. X. & Garrett, D. J. (2018). Development and Characterization of a Sucrose Microneedle Neural Electrode Bogusz, K., Tehei, M., Lerch, M., Dou, S. X., Liu, H. K. & Konstantinov, Delivery System. Advanced Biosystems, 2 (2), 1700187-1-1700187-11. K. (2018). TiO2/(BiO)2CO3 nanocomposites for ultraviolet filtration with reduced photocatalytic activity. Journal of Materials Chemistry C, 6 (21), Archer, J. & Li, E. (2018). Recent advances in photonic dosimeters for 5639-5650. medical radiation therapy. Frontiers of Optoelectronics, 11 (1), 23-29. Bolst, D., Guatelli, S., Tran, L. T. & Rosenfeld, A. B. (2018). Optimisation Archer, J., Li, E., Petasecca, M., Stevenson, A., Livingstone, J., Dipuglia, A., of the design of SOI microdosimeters for hadron therapy quality assurance. Davis, J., Rosenfeld, A. & Lerch, M. (2018). Synchrotron X-ray microbeam Physics In Medicine And Biology, 63 (21), 215007-1-215007-15. dosimetry with a 20 micrometre resolution scintillator fibre-optic dosimeter. Journal of Synchrotron Radiation, 25 (3), 826-832. Bond, S., Crowther, S. P., Adhikari, S., Yu, P., Chubaty, A. J., Borchard, J., Boutlis, C. S., Yeo, W. W. & Miyakis, S. (2018). Evaluating the effect of Archer, J., Madden, L., Li, E., Carolan, M. & Rozenfeld, A. (2018). A a Web-based e-learning tool for health professional education on clinical comparison of temporal Cherenkov separation techniques in pulsed signal vancomycin use: a comparative study. JMIR Medical Education, 4 (1), 1-9. scintillator dosimetry. Biomedical Physics and Engineering Express, 4 (4), 044003-1-044003-7. Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. (2018). Three-dimensional neural Auranwiwat, C., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., cultures produce networks that mimic native brain activity. Journal of Tissue Pyne, S. G. & Limtharakul, T. (2018). Four new C-benzyl flavonoids from the Engineering and Regenerative Medicine, 12 (2), 490-493. fruit of Uvaria cherrevensis. Fitoterapia, 130 198-202. Breitbarth, A. K., Moller, J. & Jones, A. L. (2018). E-cigarettes: An unintended Aziz, S., Naficy, S., Foroughi, J., Brown, H. R. & Spinks, G. M. (2018). illicit drug delivery system. Drug and Alcohol Dependence, 192 98-111. Twist-coil coupling fibres for high stroke tensile artificial muscles. Sensors and Actuators A: Physical, 283 98-106. Brungs, D., Aghmesheh, M., de Souza, P., Carolan, M., Clingan, P., Rose, J. & Ranson, M. (2018). Safety and Efficacy of Oxaliplatin Doublet Adjuvant Bakr, S., Cohen, D. D., Siegele, R., Incerti, S., Ivanchenko, V., Mantero, A., Chemotherapy in Elderly Patients With Stage III Colon Cancer. Clinical Rosenfeld, A. & Guatelli, S. (2018). Latest Geant4 developments for PIXE Colorectal Cancer, 17 (3), e549-e555. applications. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 436 285-291. Brungs, D., Lynch, D., Luk, A. W. S., Minaei, E., Ranson, M., Aghmesheh, M., Vine, K. L., Carolan, M., Jaber, M., de Souza, P. & Becker, T. M. (2018). Batarseh, A. M., Abbott, S. K., Duchoslav, E., Alqarni, A., Blanksby, S. J. Cryopreservation for delayed circulating tumor cell isolation is a valid strategy & Mitchell, T. W. (2018). Discrimination of isobaric and isomeric lipids in for prognostic association of circulating tumor cells in gastroesophageal cancer. complex mixtures by combining ultra-high pressure liquid chromatography World Journal of Gastroenterology, 24 (7), 810-818. with collision and ozone-induced dissociation. International Journal of Mass Spectrometry, 431 27-36. Buckley, B. J., Aboelela, A., Minaei, E., Jiang, L. X., Xu, Z., Ali, U., Fildes, K., Cheung, C., Cook, S. M., Johnson, D. C., Bachovchin, D. A., Cook, G. Belfiore, L., Saunders, D. N., Ranson, M., Thurecht, K. J., Storm, G. & M., Apte, M., Huang, M., Ranson, M. & Kelso, M. J. (2018). 6-Substituted Perrow, K. L. (2018). Towards clinical translation of ligand-functionalized Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective liposomes in targeted cancer therapy: Challenges and opportunities. Journal Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. of Controlled Release, 277 1-13. Journal of Medicinal Chemistry, 61 (18), 8299-8320.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 49 Buckley, J. G., Wilkinson, D., Malaroda, A. & Metcalfe, P. (2018). Davis, J. A., Paino, J. R., Dipuglia, A., Cameron, M., Siegele, R., Investigation of the radiation dose from cone-beam CT for image-guided Pastuovic, Z., Petasecca, M., Perevertaylo, V. LB., Rosenfeld, A. & Lerch, radiotherapy: A comparison of methodologies. Journal of Applied Clinical M. L. F. (2018). Characterisation and evaluation of a PNP strip detector for Medical Physics, 19 (1), 174-183. synchrotron microbeam radiation therapy. Biomedical Physics & Engineering Express, 4 (4), 044002-1-044002-15. Butler, N. M., Hendra, R., Bremner, J. B., Willis, A. C., Lucantoni, L., Avery, V. M. & Keller, P. A. (2018). Cascade reactions of indigo with Debrot, E., Newall, M., Guatelli, S., Petasecca, M., Matsufuji, N. & Rosenfeld, oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and A. B. (2018). A silicon strip detector array for energy verification and quality spiro-oxazocinodiindoles. Organic and Biomolecular Chemistry, 16 (33), assurance in heavy ion therapy. Medical Physics, 45 (2), 953-962. 6006-6016. Debrot, E., Tran, L., Chartier, L., Bolst, D., Guatelli, S., Vandevoorde, C., Cai, F., Xu, N., Liu, Z., Ding, R., Yu, S., Dong, M., Wang, S., Shen, J., Tae, de Kock, E., Beukes, P., Symons, J., Nieto-Camero, J., Prokopovich, D. H-S., Adams, D.J., Zhang, X. & Dai, Q. (2018). Targeting of N-type calcium A., Chiriotti, S., Parisi, A., De Saint-Hubert, M., Vanhavere, F., Slabbert, channels via GABAB receptor activation by α-conotoxin Vc1.1 variants J. & Rosenfeld, A. B. (2018). SOI microdosimetry and modified MKM for displaying improved analgesic activity. Journal of Medicinal Chemistry, 61, evaluation of relative biological effectiveness for a passive proton therapy 10198-10205. radiation field. Physics in Medicine and Biology, 63 (23), 235007-1- 235007-9. Carrara, M., Cutajar, D., Alnaghy, S., Espinoza, A., Romanyukha, A., Presilla, S., Tenconi, C., Cerrotta, A., Fallai, C., Safavi-Naeini, M., Deshpande, S., Blake, S. J., Xing, A., Metcalfe, P. E., Holloway, L. C. & Petasecca, M., Kejda, A., Lerch, M., Corde, S., Jackson, M., Howie, Vial, P. (2018). A simple model for transit dosimetry based on a water A., Bucci, J. & Rosenfeld, A. B. (2018). Semiconductor real-time quality equivalent EPID. Medical Physics, 45 (3), 1266-1275. assurance dosimetry in brachytherapy. Brachytherapy, 17 (1), 133-145. Di Bella, C., Duchi, S., O'Connell, C. D., Blanchard, R., Augustine, C., Carroll, A. W., Savaspun, K., Willis, A. C., Hoshino, M., Kato, A. & Pyne, Yue, Z., Thompson, F., Richards, C., Beirne, S., Onofrillo, C., Bauquier, S. S. G. (2018). Total Synthesis of Natural Hyacinthacine C5, and six Related H., Ryan, S. D., Pivonka, P., Wallace, G. G. & Choong, P. F. (2018). In situ Hyacinthacine C5 Epimers. Journal of Organic Chemistry, 83 (10), 5558- handheld three-dimensional bioprinting for cartilage regeneration. Journal of 5576. Tissue Engineering and Regenerative Medicine, 12 (3), 611-621.
Castro, J., Grundy, L., Deiteren, A., Harrington, A.M., O’Donnell, T., Dobie, C., Montgomery, A. P., Szabo, R., Skropeta, D. & Yu, H. (2018). Maddern, J., Moore, J., Garcia-Caraballo, S., Yu, R., Kaas, Q., Craik, Computer-aided design of human sialyltransferase inhibitors of hST8Sia III. D.J., Adams, D.J. & Brierley, S.M. (2018). Cyclic analogues of α-conotoxin Journal of Molecular Recognition, 31 (2), e2684-1-e2684-11. Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology 175, 2384- Duncan, M., Newall, M. K., Caillet, V., Booth, J. T., Keall, P. J., Lerch, 2398. M., Perevertaylo, V., Rosenfeld, A. B. & Petasecca, M. (2018). Real-time high spatial resolution dose verification in stereotactic motion adaptive arc Chandna, R., Tae, H-S., Seymour, V.A.L., Chathrath S., Adams, D.J. & Kini, radiotherapy. Journal of Applied Clinical Medical Physics, 19 (4), 173-184. R.M. (2018). Drysdalin, a novel long-chain neurotoxin from the venom of Drysdalia coronoides highlights the importance of functional rather than Dundas, K., Pogson, E., Batumalai, V., Delaney, G., Boxer, M., Yap, M., structural conservation in its activity at nicotinic acetylcholine receptors. FASEB Ahern, V., Chan, C., David, S., Dimigen, M., Harvey, J., Koh, E., Lim, BioAdvances 1(2), 115-131. K., Papadatos, G., Lazarus, E., Descellar, J., Metcalfe, P. & Holloway, L. (2018). The impact of imaging modality (CT vs MRI) and patient position Chartier, L., Tran, L. T., Bolst, D., Guatelli, S., Pogossov, A., Prokopovich, D. (supine vs prone) on tangential whole breast radiation therapy planning. A., Reinhard, M. I., Perevertaylo, V., Anderson, S., Beltran, C., Matsufuji, Practical Radiation Oncology, 8 (3), e87-e97. N., Jackson, M. & Rosenfeld, A. B. (2018). Microdosimetric applications in proton and heavy ion therapy using silicon microdosimeters. Radiation Engels, E., Westlake, M., Li, N., Vogel, S., Gobert, Q., Thorpe, N., Protection Dosimetry, 180 (1-4), 365-371. Rosenfeld, A., Lerch, M., Corde, S. & Tehei, M. (2018). Thulium Oxide Nanoparticles: A new candidate for image-guided radiotherapy. Biomedical Chen, Z., You, J., Liu, X., Cooper, S., Hodge, C., Sutton, G., Crook, J. M. & Physics and Engineering Express, 4 (4), 044001-1-044001-11. Wallace, G. G. (2018). Biomaterials for corneal bioengineering. Biomedical Materials, 13 (3), 032002-1-032002-27. Geraghty, N. J., Adhikary, S. R., Cuthbertson, P., Ly, D., Guy, T. V., Belfiore, L., Fuller, S. J., Alexander, S. I., Watson, D. & Sluyter, R. (2018). Pro- Chilingaryan, Z., Headey, S. J., Lo, A. T. Y., Xu, Z., Otting, G., Dixon, N. inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease E., Scanlon, M. J. & Oakley, A. J. (2018). Fragment-based discovery of in humanised mice. Purinergic Signalling, 14 (Supplement 1), S57-S58. inhibitors of the bacterial DnaG-SSB interaction. Antibiotics, 7 (1), 14-1-14- 12. Fares, M., Abd El Hadi, S. R., Eladwy, R. A., Shoun, A. A., Abdel-Aziz, M. M., Eldehna, W. M., Abdel-Aziz, H. A. & Keller, P. A. (2018). An improved Choi, J. H., Cutajar, D., Metcalfe, P. & Downes, S. (2018). Application synthesis of pyrido[2,3-: d] pyrimidin-4(1 H)-ones and their antimicrobial of MOSkin detector for in vivo dosimetry on total skin electron therapy activity. Organic and Biomolecular Chemistry, 16 (18), 3389-3395. (TSET). Biomedical Physics and Engineering Express, 4 (2), 024002-1- 024002-9. Francis, S. L., Di Bella, C., Wallace, G. G. & Choong, P. F. M. (2018). Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology- Chung, J. H. Y., Kade, J., Jeiranikhameneh, M., Yue, Z., Mukherjee, Barriers to Clinical Translation. Frontiers in Surgery, 5 70-1-70-12. P. & Wallace, G. G. (2018). A bioprinting printing approach to regenerate cartilage for microtia treatment. Bioprinting, 12 e00031- Frost, H. R., Sanderson-Smith, M., Walker, M., Botteaux, A. & Smeesters, 1-e00031-11. P. R. (2018). Group A streptococcal M-like proteins: From pathogenesis to vaccine potential. FEMS Microbiology Reviews, 42 (2), 193-204. Cuny, H., Yu, R., Tae, H-S., Kompella, S.N. & Adams, D.J. (2018). α-Conotoxins active at α3-containing nicotinic acetylcholine receptors Fu, Y., Han, D., Wang, Y., Di, X., Yu, H. & Mu, T. (2018). Remodeling and their molecular determinants for selective inhibition. British Journal of the endoplasmic reticulum proteostasis network restores proteostasis Pharmacology 175, 1855-1868. of pathogenic GABA A receptors. PLoS One, 13 (11), e0207948- 1-e0207948-23. Davis, K. J., Assadawi, N. M. O., Pham, S. Q. T., Birrento, M. L., Richardson, C., Beck, J. L., Willis, A. C. & Ralph, S. F. (2018). Effect of Gargett, M., Oborn, B., Alnaghy, S. J., Causer, T., Petasecca, M., structure variations on the quadruplex DNA binding ability of nickel Schiff Rosenfeld, A. B. & Metcalfe, P. (2018). A high resolution 2D array detector base complexes. Dalton Transactions: an international journal of inorganic system for small-field MRI-linac applications. Biomedical Physics and chemistry, 47 (38), 13573-13591. Engineering Express, 4 (3), 035041-1-035041-11
50 2018-2019 ANNUAL REPORT Ghodke, H., Ho, H. & van Oijen, A. M. (2018). Single-molecule live-cell Incerti, S., Kyriakou, I., Bernal, M. A., Bordage, M. C., Francis, Z., Guatelli, imaging of bacterial DNA repair and damage tolerance. Biochemical S., Ivanchenko, V., Karamitros, M., Lampe, N., Lee, S. B., Meylan, S., Min, Society Transactions, 46 23-35. C. H., Shin, W. G., Nieminen, P., Sakata, D., Tang, N., Villagrasa, C., Tran, H. N. & Brown, J. M. C. (2018). Geant4-DNA example applications Gordon, C. P., Dalton, N., Vandegraaff, N., Deadman, J., Rhodes, D. I., for track structure simulations in liquid water: A report from the Geant4-DNA Coates, J. A., Pyne, S. G., Griffith, R., Bremner, J. B. & Keller, P. A. (2018). Project. Medical Physics, 45 (8), e722-e739. A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors. Tetrahedron, 74 (12), 1253-1268. Jaidee, W., Maneerat, W., Andersen, R. J., Patrick, B. O., Pyne, S. G. & Laphookhieo, S. (2018). Antioxidant neolignans from the twigs and leaves of Gu, Q., Tomaskovic-Crook, E., Wallace, G. & Crook, J. (2018). Mitrephora wangii HU. Fitoterapia, 130 219-224. Engineering human neural tissue by 3D bioprinting. Biomaterials for tissue engineering: methods and protocols (pp. 129-138). United States: Humana Jarrett, L., Georgiou, H., Lerch, M., Takacs, G. & Zealey, W. (2018). Press, Inc. Supporting Physics Teachers to Deliver the New High School Certificate Syllabus: What are the Priorities?. 2018 IEEE International Conference on Hai, F. I., Yang, S., Asif, M. B., Sencadas, V., Shawkat, S., Sanderson- Teaching, Assessment, and Learning for Engineering (TALE) (pp. 798-801). Smith, M., Gorman, J., Xu, Z. & Yamamoto, K. (2018). Carbamazepine United States: IEEE. as a Possible Anthropogenic Marker in Water: Occurrences, Toxicological Effects, Regulations and Removal by Wastewater Treatment Technologies. Javadi, M., Gu, Q., Naficy, S., Farajikhah, S., Crook, J. M., Wallace, G. G., Water, 10 (2), 107-1-107-32. Beirne, S. & Moulton, S. (2018). Conductive Tough Hydrogel for Bioapplications. Macromolecular Bioscience, 18 (2), 1700270-1-1700270-11. Harris, A. R. & Wallace, G. G. (2018). Organic Electrodes and Communications with Excitable Cells. Advanced Functional Materials, 28 Jin, D., Xi, P., Wang, B., Zhang, L., Enderlein, J. & van Oijen, A. M. (2018). (12), 1700587-1-1700587-23. Nanoparticles for super-resolution microscopy and single-molecule tracking. Nature Methods, 15 415-423. Harris, A. R., Newbold, C., Carter, P., Cowan, R. & Wallace, G. G. (2018). Charge Injection from Chronoamperometry of Platinum Electrodes Johnston, T., Van Tyne, D., Chen, R. F., Fawzi, N. L., Kwon, B., Kelso, M. for Bionic Devices. Journal Of The Electrochemical Society, 165 (12), J., Gilmore, M. S. & Mylonakis, E. (2018). Propyl-5-hydroxy-3-methyl-1- G3033-G3041. phenyl-1H-pyrazole-4-carbodithioate (HMPC): A new bacteriostatic agent against methicillin - Resistant Staphylococcus aureus. Scientific Reports, 8 (1), Harris, A. R., Newbold, C., Carter, P., Cowan, R. & Wallace, G. G. 7062-7062. (2018). Measuring the effective area and charge density of platinum electrodes for bionic devices. Journal of Neural Engineering, 15 (4), Jones, A. (2018). Poisoning and overdose. In D. Provan (Ed.), Oxford 046015-1-046015-12. Handbook of Clinical and Laboratory Investigation (pp. 699-740). Oxford, United Kingdom: Oxford University Press. Harris, P.N.A., Tambyah, P.A., Lye, D.C., Mo, Y., Lee, T.H., Yilmaz, M., Alenazi, T.H., Arabi, Y., Falcone, M., Bassetti, M., Righi, E., Rogers, B. Jong, W. L., Ung, N. M., Tiong, A. H.L., Rosenfeld, A. B. & Wong, J. H.D. A., Kanj, S., Bhally, H., Iredell, J., Mendelson, M., Boyles, T. H., Looke, (2018). Characterisation of a MOSFET-based detector for dose measurement D., Miyakis, S., Walls, G., Al Khamis, M., Zikri, A., Crowe, A., Ingram, under megavoltage electron beam radiotherapy. Radiation Physics and P., Daneman, N., Griffin, P., Athan, E., Lorenc, P., Baker, P., Roberts, L., Chemistry: the journal for radiation physics, radiation chemistry and radiation Beatson, S. A., Peleg, A. Y., Harris-Brown, T. & Paterson, D. (2018). Effect processing, 144 76-84. of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with e coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone Kang, L., Liu, X., Yue, Z., Chen, Z., Baker, C., Winberg, P. C. & Wallace, resistance. JAMA: Journal of the American Medical Association, 320 (10), G. G. (2018). Fabrication and in vitro characterization of electrochemically 984-994. compacted collagen/sulfated xylorhamnoglycuronan matrix for wound healing applications. Polymers, 10 (4), 1-13. Harvey, P.J., Kurniawan, N.D., Finol-Urdaneta, R.K., McArthur, J.R., Van Lysebetten, D., Dash, T.S., Hill, J.M., Adams, D.J., Durek, T. & Craik, D.J. Lazarakis, P., Incerti, S., Ivanchenko, V., Kyriakou, I., Emfietzoglou, D., (2018). NMR structure of μ-conotoxin GIIIC: Leucine 18 induces local Corde, S., Rosenfeld, A. B., Lerch, M., Tehei, M. & Guatelli, S. (2018). repacking of the N-terminus resulting in reduced NaV channel potency. Investigation of track structure and condensed history physics models for Biomolecules 23(10), 2715. applications in radiation dosimetry on a micro and nano scale in Geant4. Biomedical Physics and Engineering Express, 4 (2), 024001-1-024001-11. Hayes, A. R., Brungs, D. & Pavlakis, N. (2018). Osteoclast inhibitors to prevent bone metastases in men with high-risk, nonmetastatic prostate cancer: Liu, Z., Bartels, P., Sadeghi, M., Du, T., Dai, Q., Zhu, C., Yu, S., Wang, S., A systematic review and meta-Analysis. PLoS One, 13 (1), e0191455- Dong, M., Sun, T., Guo, J., Peng, S., Jiang, L., Adams, D. J. & Dai, Q. (2018). 1-e0191455-14. A novel a-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. Scientific Reports, 8 1004-1-1004-13. Henrikus, S. S., van Oijen, A. M. & Robinson, A. (2018). Specialised DNA polymerases in Escherichia coli: roles within multiple pathways. Current Liu, J., Ebrahimi, A., Low, T., Gao, K., Palme, C. E., Sydney, C., Ashford, Genetics: lower eukaryotes and organelles, 64 (6), 1189-1196. B. G., Iyer, N., Clark, J. R. & Gupta, R. (2018). Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for Henrikus, S. S., Wood, E. A., Mcdonald, J. P., Cox, M. M., Woodgate, patients with cutaneous squamous cell carcinoma of the head and neck. R., Goodman, M. F., van Oijen, A. M. & Robinson, A. (2018). DNA Journal of Surgical Oncology, 117 (4), 765-772. polymerase IV primarily operates outside of DNA replication forks in Escherichia coli. PLoS Genetics, 14 (1), e1007161-1-e1007161-29. Machado, R., da Costa, A., Silva, D. M., Gomes, A. C., Casal, M. & Sencadas, V. (2018). Antibacterial and Antifungal Activity of Poly(Lactic Hill, F. R., van Oijen, A. M. & Duderstadt, K. E. (2018). Detection of Acid)-Bovine Lactoferrin Nanofiber Membranes. Macromolecular Bioscience, kinetic change points in piece-wise linear single molecule motion. Journal of 18 (3), 1700324-1-1700324-10. Chemical Physics, 148 (12), 123317-1-123317-9. Madden, L., Archer, J., Li, E., Wilkinson, D. & Rosenfeld, A. (2018). Temporal Ho, H. N., van Oijen, A. M. & Ghodke, H. (2018). The transcription-repair separation of Cerenkov radiation and scintillation using artificial neural coupling factor Mfd associates with RNA polymerase in the absence of networks in Clinical LINACs. Physica Medica: an international journal devoted exogenous damage. Nature Communications, 9 1570-1-1570-12. to the applications of physics to medicine and biology, 54 131-136.
Hu, N., Uchida, R., Tran, L. T., Rosenfeld, A. & Sakurai, Y. (2018). Madden, L., Archer, J., Li, E., Wilkinson, D. & Rosenfeld, A. (2018). Feasibility study on the use of 3D silicon microdosimeter detectors for Temporal separation of Cerenkov radiation and scintillation using a clinical microdosimetric analysis in boron neutron capture therapy. Applied Radiation LINAC and artificial intelligence. Physics in Medicine and Biology, 63 (22), and Isotopes, 140 109-114. 225004-1-225004-11.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 51 Majed, H., Johnston, T., Kelso, C., Monachino, E., Jergic, S., Dixon, N. Nguyen, P. T. V., Yu, H. & Keller, P. A. (2018). Molecular docking studies E., Mylonakis, E. & Kelso, M. J. (2018). Structure-activity relationships of to explore potential binding pockets and inhibitors for chikungunya virus pyrazole-4-carbodithioates as antibacterials against methicillin-resistant envelope glycoproteins. Interdisciplinary Sciences: Computational Life Staphylococcus aureus. Bioorganic and Medicinal Chemistry Letters, 28 Sciences, 10 (3), 515-524. (22), 3526-3528. Onofrillo, C., Duchi, S., O'Connell, C. D., Blanchard, R., Scott, M., McArthur, J.R., Motin, L., Gleeson, E.G., Graham, J.E., Lewis, R.J., Duggan, O'Connor, A. J., Wallace, G. G., Choong, P. F. M. & Di Bella, C. P.J., Tuck, K.L. & Adams, D.J. (2018). Inhibition of human N- and T-type (2018). Biofabrication of human articular cartilage: a path towards the calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British development of a clinical treatment. Biofabrication, 10 (4), 045006-1- Journal of Pharmacology 175, 2284-2295. 045006-19.
McCaul, M., Porter, A., Barrett, R., White, P., Stroiescu, F., Wallace, G. & Park, J., Jergic, S., Jeon, Y., Cho, W., Lee, R., Dixon, N. E. & Lee, J. (2018). Diamond, D. (2018). Wearable Platform for Real-time Monitoring of Sodium Dynamics of Proofreading by the E. coli Pol III Replicase. Cell Chemical in Sweat. ChemPhysChem: a European journal of chemical physics and Biology, 25 (1), 57-66. physical chemistry, 19 (12), 1531-1536. Paull, O. H. C., Pan, A. V., Causer, G. L., Fedoseev, S. A., Jones, A., Liu, X., McCauley, J. I., Winberg, P. C., Meyer, B. J. & Skropeta, D. (2018). Effects Rosenfeld, A. & Klose, F. (2018). Field dependence of the ferromagnetic/ of nutrients and processing on the nutritionally important metabolites of Ulva superconducting proximity effect in a YBCO/STO/LCMO multilayer. sp. (Chlorophyta). Algal Research, 35 586-594. Nanoscale, 10 (40), 18995-19003.
McDonald, M., Corde, S., Lerch, M., Rosenfeld, A., Jackson, M. & Tehei, M. Poad, B. L. J., Maccarone, A. T., Yu, H., Mitchell, T. W., Saied, E. M., (2018). First in vitro evidence of modulated electro-hyperthermia treatment Arenz, C., Hornemann, T., Bull, J. N., Bieske, E. J. & Blanksby, S. J. (2018). performance in combination with megavoltage radiation by clonogenic Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New assay. Scientific Reports, 8 16608-1-16608-13. Insights into the Gas Phase Structures of Ionized Lipids. Analytical Chemistry, 90 (8), 5343-5351. McDonald, M., Oktaria, S., Konstantinov, K., Rosenfeld, A., Lerch, M., Corde, S. & Tehei, M. (2018). Radiosensitisation enhancement effect of Poad, B. L. J., Zheng, X., Mitchell, T. W., Smith, R. D., Baker, E. S. & BrUdR and Ta2O5 NSPs in combination with 5-Fluorouracil antimetabolite in Blanksby, S. J. (2018). Online Ozonolysis Combined with Ion Mobility-Mass kilovoltage and megavoltage radiation. Biomedical Physics and Engineering Spectrometry Provides a New Platform for Lipid Isomer Analyses. Analytical Express, 4 (3), 034001-1-034001-14. Chemistry, 90 (2), 1292-1300.
McGrath, A. E., Martyn, A. P., Whittell, L. R., Dawes, F. E., Beck, J. L., Poder, J., Cutajar, D., Guatelli, S., Petasecca, M., Howie, A., Bucci, J. & Dixon, N. E., Kelso, M. J. & Oakley, A. J. (2018). Crystal structures and Rozenfeld, A. (2018). HDR brachytherapy in vivo source position verification biochemical characterization of DNA sliding clamps from three Gram- using a 2D diode array: A Monte Carlo study. Journal of Applied Clinical negative bacterial pathogens. Journal of Structural Biology, 204 (3), 396- Medical Physics, 19 (4), 163-172. 405. Pogson, E. M., Arumugam, S., Hansen, C. R., Currie, M., Blake, S. J., Michael, K. (2018). Brain Pacemakers in Consumer Medical Electronics Roberts, N., Carolan, M., Vial, P., Alharthi, T., Holloway, L. & Thwaites, Improve Quality of Life: Benefits, Risks, and Challenges. IEEE Consumer D. I. (2018). Comparison of multi-institutional pre-treatment verification Electronics Magazine, 7 (4), 82-85. for VMAT of nasopharynx with delivery errors. Physica Medica: an international journal devoted to the applications of physics to medicine and Michael, K. (2018). Brain Pacemakers in Consumer Medical Electronics biology, 53 25-31. Improve Quality of Life-Part II: The Need for Patient Feedback in the Product Lifecycle Management. IEEE Consumer Electronics Magazine, 7 Promchai, T., Saesong, T., Ingkaninan, K., Laphookhieo, S., Pyne, S. G. & (6), 51-54. Limtharakul, T. (2018). Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii. Phytochemistry Letters, 23 33-37. Minaei, E., Brungs, D., Engels, E., Vine, K. L., Tehei, M. L., Corde, S. & Ranson, M. (2018). Drug and radio sensitivity profile of a primary CTC cell Raksat, A., Maneerat, W., Andersen, R. J., Pyne, S. G. & Laphookhieo, S. line derived from a patient with metastatic neuroendocrine tumour of the (2018). Antibacterial Prenylated Isoflavonoids from the Stems of Millettia distal oesophagus. ESMO Open (pp. A402-A403). United Kingdom: B M J extensa. Journal of Natural Products, 81 (8), 1835-1840. Group. Rashad, A. A., Neyts, J., Leyssen, P. & Keller, P. A. (2018). A reassessment Moeckelmann, N., Ebrahimi, A., Dirven, R., Liu, J., Low, T., Gupta, R., of mycophenolic acid as a lead compound for the development of inhibitors Ashford, B., Ch'ng, S., Palme, C. & Clark, J. R. (2018). Analysis and of chikungunya virus replication. Tetrahedron, 74 (12), 1294-1306. Comparison of the 8th Edition American Joint Committee on Cancer (AJCC) Nodal Staging System in Cutaneous and Oral Squamous Cell Ren, W., Wen, S., Tawfik, S. Abdulkader., Su, Q. P., Lin, G., Ju, L. A., Cancer of the Head and Neck. Annals of Surgical Oncology, 25 (6), Ford, M. J., Ghodke, H., van Oijen, A. M. & Jin, D. (2018). Anisotropic 1730-1736. functionalization of upconversion nanoparticles. Chemical Science, 9 (18), 4352-4358. Moeckelmann, N., Ebrahimi, A., Tou, Y. K., Gupta, R., Low, T., Ashford, B. G., Ch'ng, S., Palme, C. E. & Clark, J. R. (2018). Prognostic implications of Rineh, A., Bremner, J. B., Hamblin, M. R., Ball, A. R., Tegos, G. P. & Kelso, the 8th edition American Joint Committee on Cancer (AJCC) staging system in M. J. (2018). Attaching NorA efflux pump inhibitors to methylene blue oral cavity squamous cell carcinoma. Oral Oncology, 85 82-86. enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo. Bioorganic and Medicinal Molino, P. J., Garcia, L., Stewart, E. M., Lamaze, M., Zhang, B., Harris, Chemistry Letters, 28 (16), 2736-2740. A. R., Winberg, P. & Wallace, G. G. (2018). PEDOT doped with algal, mammalian and synthetic dopants: polymer properties, protein and S. Ameli, F. Naghdy, D. Stirling, G. Naghdy, M. Aghmesheh, R. Anthony, cell interactions, and influence of electrical stimulation on neuronal cell P. McLennan & G. Peoples, "Measurement and validation of exercise induced differentiation. Biomaterials Science, 6 (5), 1250-1261. fatigue through inertial motion analysis," ASME Journal of Engineering and Science in Medical Diagnostics and Therapy, vol. 1, pp. 021007-1- Monachino, E., Ghodke, H., Spinks, R. R., Hoatson, B. S., Jergic, S., 021007-11, 2018. Xu, Z., Dixon, N. E. & van Oijen, A. M. (2018). Design of DNA rolling- circle templates with controlled fork topology to study mechanisms of DNA Sakata, D., Kyriakou, I., Okada, S., Tran, H. N., Lampe, N., Guatelli, replication. Analytical Biochemistry, 557 42-45. S., Bordage, M., Ivanchenko, V., Murakami, K., Sasaki, T., Emfietzoglou, D. & Incerti, S. (2018). Geant4-DNA track-structure simulations for gold Morgan, J. & Jones, A. L. (2018). The role of naloxone in the opioid crisis. nanoparticles: The importance of electron discrete models in nanometer Toxicology Communications, 2 (1), 15-18. volumes. Medical Physics, 45 (5), 2230-2242.
52 2018-2019 ANNUAL REPORT Sadeghi, M., Carstens, B. B., Callaghan, B. P., Daniel, J. T., Tae, H., Tharmalingam, N., Rajmuthiah, R., Kim, W., Fuchs, B. Burgwyn., Jeyamani, O'Donnell, T., Castro, J., Brierley, S. M., Adams, D. J., Craik, D. J. & E., Kelso, M. J. & Mylonakis, E. (2018). Antibacterial Properties of Four Clark, R. J. (2018). Structure-Activity Studies Reveal the Molecular Basis for Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus- GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Caenorhabditis elegans High-Throughput Screen. Microbial Drug Resistance, Channels by a-Conotoxin Vc1.1. ACS Chemical Biology, 13 (6), 1577- 24 (5), 666-674. 1587. Tran, L. T., Bolst, D., Guatelli, S., Biasi, G., Fazzi, A., Sagia, E., Sadeghi, M., Erickson, A., Castro, J., Deiteren, A., Harrington, A. M., Prokopovich, D. A., Reinhard, M. I., Keat, Y. C., Petasecca, M., Lerch, M. Grundy, L., Adams, D. J. & Brierley, S. M. (2018). Contribution of L. F., Pola, A., Agosteo, S., Matsufuji, N., Jackson, M. & Rosenfeld, A. B. membrane receptor signalling to chronic visceral pain. The International (2018). High spatial resolution microdosimetry with monolithic Delta E-E Journal of Biochemistry and Cell Biology, 98 10-23. detector on C-12 beam: Monte Carlo simulations and experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Safavi-Naeini, M., Chacon, A., Guatelli, S., Franklin, D. R., Bambery, K., Spectrometers, Detectors, and Associated Equipment, 887 70-80. Gregoire, M. & Rosenfeld, A. (2018). Opportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal Tran, L. T., Bolst, D., Guatelli, S., Pogossov, A., Petasecca, M., Lerch, M. neutrons. Scientific Reports, 8 (1), 16257-1-16257-13. L. F., Chartier, L., Prokopovich, D. A., Reinhard, M. I., Povoli, M., Kok, A., Perevertaylo, V., Matsufuji, N., Kanai, T., Jackson, M. & Rosenfeld, A. Scales, N., Chen, J., Aughterson, R. D., Karatchevtseva, I., Stopic, A., B. (2018). The relative biological effectiveness for carbon, nitrogen, and Lumpkin, G. R. & Luca, V. (2018). Porous ZrC-carbon microspheres as oxygen ion beams using passive and scanning techniques evaluated with potential insoluble target matrices for production of 188W/188Re. Journal fully 3D silicon microdosimeters. Medical Physics, 45 (5), 2299-2308. of Radioanalytical and Nuclear Chemistry: an International Journal dealing with all Aspectsand Applications of Nuclear Chemistry, 318 (2), Tran, L. T., Chartier, L., Bolst, D., Davis, J., Prokopovich, D. A., Pogossov, 835-847. A., Guatelli, S., Reinhard, M. I., Petasecca, M., Lerch, M. L. F., Matsufuji, N., Povoli, M., Summanwar, A., Kok, A., Jackson, M. & Rosenfeld, A. B. Seng, J., Nealon, J. R., Blanksby, S. J. & Mitchell, T. W. (2018). Distribution (2018). In-field and out-of-file application in 12C ion therapy using fully 3D of Glycerophospholipids in the Adult Human Lens. Biomolecules, 8 (4), 156- silicon microdosimeters. Radiation Measurements, 115 55-59. 1-156-6. Tran, L. T., Chartier, L., Prokopovich, D. A., Bolst, D., Povoli, M., Shin, W. G., Bordage, M. C., Emfietzoglou, D., Kyriakou, I., Sakata, D., Summanwar, A., Kok, A., Pogossov, A., Petasecca, M., Guatelli, S., Min, C. H., Lee, S. B., Guatelli, S. & Incerti, S. (2018). Development of a Reinhard, M. I., Lerch, M., Nancarrow, M., Matsufuji, N., Jackson, M. & new Geant4-DNA electron elastic scattering model for liquid-phase water Rosenfeld, A. B. (2018). Thin Silicon Microdosimeter utilizing 3D MEMS using the ELSEPA code. Journal of Applied Physics, 124 (22), 224901-1- Fabrication Technology: Charge Collection Study and its application in mixed 224901-15. radiation fields. IEEE Transactions on Nuclear Science, 65 (1), 467-472.
Silva, D. M., Paleco, R., Traini, D. & Sencadas, V. (2018). Development Trautman, J., Gore, S., Potter, M., Clark, J., Hyam, D., Tan, N. C., Ngo, Q. of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung & Ashford, B. (2018). Supraclavicular flap repair in the free flap era. ANZ delivery. International Journal of Pharmaceutics, 547 (1-2), 114-121. Journal of Surgery, 88 (6), 540-546.
Silva, D. M., Vyas, H., Sanderson-Smith, M. L. & Sencadas, V. (2018). Umsumarng, S., Mapoung, S., Yodkeeree, S., Pyne, S. G. & Limtrakul Development and optimization of ciprofloxacin-loaded gelatin microparticles Dejkriengkraikul, P. (2018). A pharmacological strategy using stemofoline by single-step spray-drying technique. Powder Technology, 330 201-209. for more efficacious chemotherapeutic treatments against human multidrug resistant leukemic cells. Asian Pacific Journal of Cancer Prevention (APJCP), Sousa, S.R., McArthur, J.R., Brust, A., Bhola, R.F., Rosengren, J., 19 (12), 3533-3543. Ragnarsson, L., Dutertre, S., Alewood, P.F., Christie, M.J., Adams, D.J., Vetter, I. & Lewis, R.J. (2018). Novel analgesic ω-conotoxins from the van der Borg, G., Braddock, S., Blijleven, J. S., van Oijen, A. M. & Roos, vermivorous cone snail Conus moncuri provide new insights into the evolution W. H. (2018). Single-particle fusion of influenza viruses reveals complex of conopeptides. Scientific Reports 8, 13397. interactions with target membranes. Journal of Physics Condensed Matter, 30 (20), 204005-1-204005-7. Sriyatep, T., Tantapakul, C., Andersen, R. J., Patrick, B. O., Pyne, S. G., Muanprasat, C., Seemakhan, S., Borwornpinyo, S. & Laphookhieo, S. van Kogelenberg, S., Yue, Z., Dinoro, J. N., Baker, C. S. & Wallace, G. (2018). Resolution and identification of scalemic caged xanthones from the G. (2018). Three-Dimensional Printing and Cell Therapy for Wound Repair. leaf extract of Garcinia propinqua having potent cytotoxicities against colon Advances in Wound Care, 7 (5), 145-155. cancer cells. Fitoterapia, 124 34-41. van Oijen, A. M. (2018). Special Issue on Cell Biophysics. Biophysical Steele, J. R., Gho, S. A., Campbell, T. E., Richardson, C. J., Beirne, Journal, 115 (2), E01-E02. S., Spinks, G. M. & Wallace, G. G. (2018). The Bionic Bra: Using electromaterials to sense and modify breast support to enhance active van Tienderen, G. Sebastiaan., Berthel, M., Yue, Z., Cook, M., Liu, X., living. Journal Of Rehabilitation And Assistive Technologies Engineering, Beirne, S. & Wallace, G. G. (2018). Advanced fabrication approaches to 5 1-9. controlled delivery systems for epilepsy treatment. Expert Opinion on Drug Delivery, 15 (9), 915-925. Stephens-Fripp, B., Sencadas, V., Mutlu, R. & Alici, G. (2018). Reusable Flexible Concentric Electrodes Coated With a Conductive Graphene Ink for Vasan, K., Low, T. (Hubert)., Gupta, R., Ashford, B., Asher, R., Gao, K., Electrotactile Stimulation. Frontiers In Bioengineering And Biotechnology, 6 Ch'ng, S., Palme, C. E. & Clark, J. R. (2018). Lymph node ratio as a 179-1-179-9. prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma. Head and Neck: journal for the sciences and specialities of the Ta, H. T. T., Tieu, A. K., Zhu, H., Yu, H., Ta, T. D., Wan, S., Tran, N. V. head and neck, 40 (5), 993-999. & Le, H. M. (2018). Chemical Origin of Sodium Phosphate Interactions on Iron and Iron Oxide Surfaces by First Principle Calculations. The Journal Wang, X. & Yu, H. (2018). The effect of DNA backbone on the triplet of Physical Chemistry C: Energy Conversion and Storage, Optical and mechanism of UV-induced thymine-thymine (6—4) dimer formation. Journal of Electronic Devices, Interfaces, Nanomaterials, and Hard Matter, 122 (1), Molecular Modeling, 24 (11), 319-1-319-9. 635-647. Wang, X., Yu, L., Inakollu, V., Pan, X., Ma, J. & Yu, H. (2018). Molecular Talebian, S., Foroughi, J., Wade, S. J., Vine, K. L., Dolatshahi-Pirouz, A., Quantum Dot Cellular Automata Based on Diboryl Monoradical Anions. The Mehrali, M., Conde, J. & Wallace, G. G. (2018). Biopolymers for Antitumor Journal of Physical Chemistry C: Energy Conversion and Storage, Optical Implantable Drug Delivery Systems: Recent Advances and Future Outlook. and Electronic Devices, Interfaces, Nanomaterials, and Hard Matter, 122 Advanced Materials, 30 (31), 1706665-2-1706665-31. (4), 2454-2460.
ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE 53 Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D. & Bruning, J. B. (2018). Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp. Chemistry - A European Journal, 24 (44), 11325-11331.
Wongsomboon, P., Maneerat, W., Pyne, S. G., Vittaya, L. & Limtharakul, T. (2018). 12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea. Natural Product Communications: an international journal for communications and reviews, 13 (10), 1327-1328.
Wu, X., Tae, H-S., Huang, Y-H., Adams, D.J., Craik, D.J. & Kaas, Q. (2018). Stoichiometry-dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by ribbon α-conotoxin AuIB. Biochemical Pharmacology 155, 288-297.
Xu, C., Zhang Molino, B., Wang, X., Cheng, F., Xu, W., Molino, P., Bacher, M., Su, D., Rosenau, T., Willfor, S. & Wallace, G. (2018). 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application. Journal of Materials Chemistry B, 6 (43), 7066- 7075.
Yan, S., Tan, S. H., Li, Y., Tang, S., Teo, A. J. T., Zhang, J., Zhao, Q., Yuan, D., Sluyter, R., Nguyen, N. T. & Li, W. (2018). A portable, hand-powered microfluidic device for sorting of biological particles. Microfluidics and Nanofluidics, 22 (8), 1-10.
Xie, Y., Dahlin, J. L., Oakley, A. J., Casarotto, M. G., Board, P. G. & Baell, J. (2018). Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. Journal of Medicinal Chemistry, 61 (17), 7448-7470.
Xu, Z. & Dixon, N. E. (2018). Bacterial replisomes. Current Opinion in Structural Biology, 53 159-168.
Yan, Y., Potts, M., Jiang, Z. & Sencadas, V. (2018). Synthesis of highly- stretchable graphene - poly(glycerol sebacate) elastomeric nanocomposites piezoresistive sensors for human motion detection applications. Composites Science and Technology, 162 14-22.
Yu, R., Tae, H-S., Tabassum, N., Shi, J., Jiang, T. & Adams, D.J. (2018). Molecular determinants conferring the stoichiometric-dependent activity of α-conotoxins at the human α9α10 nicotinic acetylcholine receptor subtype. Journal of Medicinal Chemistry, 61, 4628-4634.
Zhang, H., Gu, Q., Wallace, G. G. & Higgins, M. J. (2018). Effect of electrochemical oxidation and reduction on cell de-adhesion at the conducting polymer-live cell interface as revealed by single cell force spectroscopy. Biointerphases: an open access journal for the biomaterials interface community, 13 (4), 041004-1-041004-13.
Zhang, Q., Beirne, S., Shu, K., Esrafilzadeh, D., Huang, X. & Wallace, G. G. (2018). Electrical Stimulation with a Conductive Polymer Promotes Neurite Outgrowth and Synaptogenesis in Primary Cortical Neurons in 3D. Scientific Reports, 8 (1), 9855-1-9855-10.
Zhao, J., Ru, C., Bai, Y., Wang, X., Chen, W., Wang, X., Pan, X. & Wu, J. (2018). Synthesis of Bis-Cycloborate Olefin and Butatriene Derivatives through the Reduction of Alkynyl-Bridged Diboryl Compounds. Inorganic Chemistry, 57 (20), 12552-12561.
Zilberg, C., Lee, M. Weicai., Yu, B., Ashford, B., Kraitsek, S., Ranson, M., Shannon, K., Cowley, M., Iyer, N., Palme, C. E., Ch'ng, S., Low, T. (Hubert)., O'Toole, S., Clark, J. R. & Gupta, R. (2018). Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma. Modern Pathology, 31 275-287.
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