Case Report iMedPub Journals Journal of Neurology and Neuroscience 2018 www.imedpub.com Vol.9 No.6:275 ISSN 2171-6625 DOI: 10.21767/2171-6625.1000275 Molecular Analysis of PANK2 Gene in Two Thai Classic Pantothenate Kinase- Associated Neurodegeneration (PKAN) Patients Piradee Suwanpakdee1, Napakjira Likasitthananon1, Charcrin Nabangchang1, Yutthana Pansuwan2, Siriporn Pattharathitikul3 and Boonchai Boonyawat4 1Division of Neurology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand 2Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand 3Division of Pediatrics, Prapokklao Hospital, Bangkok, Thailand 4Division of Genetics, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand *Corresponding author: Dr. Piradee Suwanpakdee, MD, Division of Neurology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, 315 Ratchawithi Rd, Thung Phaya Thai, Ratchathewi district, Bangkok 10400, Thailand, Tel: +66814383634; E-mail:
[email protected] Rec Date: October 25, 2018; Acc Date: November 10, 2018, 2018; Pub Date: November 14, 2018 Citation: Suwanpakdee P, Likasitthananon N, Nabangchang C, Pansuwan Y, Pattharathitikul S, et al. (2018) Molecular Analysis of PANK2 Gene in Two Thai Classic Pantothenate Kinase-Associated Neurodegeneration (PKAN) Patients. J Neurol Neurosci Vol.9 No.6:275. Keywords: Molecular analysis; PANK2 gene; Pantothenate Abstract kinase-associated neurodegeneration (PKAN); Thailand Background: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare neurodegenerative Introduction disorder that occurs due to autosomal recessive Pantothenate kinase-associated neurodegeneration (PKAN, mutations in the PANK2 gene. Several of these pathogenic mutations have been identified, and ethnic differences OMIM 234220), previously named Hallervorden-Spatz seem to play an important role in the clinical outcomes of syndrome, is a rare autosomal recessive neurodegeneration this disease.