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Home , Bemiparin sodium, Certoparin sodium, Dalteparin sodium, Reviparin sodium

Supplementary data

Appendix

Table 1: keywords

NOACs , pradaxa, abigatra, dabagatran, dabegatran, dibagatran, ibegatran, dibigatran, debegatran, debigatran, debagatran, dabigetran, dabegetran, dabagetran, debigetran, debagetran, debegetran, dibigetran, dibagetran, dibegetran, , xarelto, rivarox, aroxab, riveroxaban, rivoroxaban, riviroxaban, revaroxaban, reviroxaban, reveroxaban, revoroxaban, raviroxaban, raveroxaban, ravaroxaban, ravoroxaban, raviroxeban, raveroxeban, ravaroxeban, ravoroxeban, rivaroxeban, riveroxeban, rivoroxeban, riviroxeban, revaroxeban, reviroxeban, reveroxeban, revoroxeban, xaretlo, xaralto, xaratlo, xirelto, , eliquis, apixeban, apixiban, apixoban, apaxiban, apaxeban, apaxaban, apaxoban, apexiban, apexaban, apexoban, apoxaban, apoxeban, apoxiban, apoxoban, eliquies, elicquis, rivarocaban, reberoxeran, rivavonabam

Heparins , monoparin, unihep, calciparine, hepsal, canusal, multiparin, minihep, unfractionated heparin, ufh, heperin, hepirin, haparin, hapirin, hiparin, hiperin, hipirin, monopar, calcipar, multipar, bemiparin, zibor, bemip,mipa bemiprin, bemeparin, bemaparin, bemoparin, bimeparin, bamiparin, bameparin, bemiparine, zibro, certoparin, alphaparin, topari, certoprin, certeparin, certaparin, certiparin, cartoparin, certoparine, cetroparin, alfaparin, alphaprin, alphap, phapa, dalteparin, fragmin, tepari, dalteprin, daltoparin, daltaparin, daltiparin, delteparin, deltiparin, deltoparin,dilteparin, diltaparin, dolteparin, doltaparin, doltiparin, dalteparine, fragmine, fragmi, framgin, enoxaparin, clexane, noxapa, enoxaprin, xapar, enoxiparin, enoxeparin, enaxaparin, enaxeparin, enaxiparin, enaxoparin, enoxaparine, claxane, clexa, lexan, reviparin, clivarine, revipa, reviprin, reveparin, revaparin, raviparin, reviparine, clivarin, clivar, ivari, tinzaparin, innohep, tinza, zapar, tinzaprin, tinzeparin, tinziparin, tinzoparin, tanziparin, tanzeparin, tanzaparin, tanzoparin, tenzoparin, tenzaparin, tenziparin, tinzaparine, inohep, enoxoparin , arixtra, fondap, dapari, parinux, fondaprinux, fondapinux, fondeparinux, fondaparinyx, fondaparinix, fondeparinyx, fondeparinix, arixt, arextra,

Acetylsalicylic acid acetylsalicylic acid, , micropirin, nu-seals, aspro, caprin, angettes, acetyl salicylic acid, acetylsal, acetylsalycilic acid, acetylsalycylic acid, acetylsalycylyc acid, acetylsalycilyc acid, acatylsalicylic acid, acatylsalicylyc acid, acatylsalycylyc acid, acatylsalycylic acid, acetylsalisylic acid, aspirn, asprin, aspirine, asperin, pirin, micropirine, microperin, micropirrin, microperrin, nuseals, nu- saels, nusaels, micropi, ropiri, apsro, asrpo, angett,

Table 2: medical and product codes in CPRD

Total Knee Replacement codes

medcode clinicalevents readterm

5362 35980 TKR -Total prosthetic replacement of knee joint using cement

3414 27645 Total prosthetic replacement of knee joint using cement

673 23071 Other total prosthetic replacement of knee joint NOS

3973 21002 TKR - Other total prosthetic replacement of knee joint

8555 16255 Other total prosthetic replacement of knee joint

28048 8575 Primary total knee replacement NEC

20746 1727 Primary cemented total knee replacement

9877 1450 TKR - Total prosthetic replacement knee joint without cement

17471 1365 Total prosthetic replacement of knee joint not using cement

94310 1300 Unicompartmental knee replacement NOS

10406 1102 Other arthroplasty of knee joint

11225 970 Cemented unicompartmental knee replacement

10372 848 Total prosthetic replacement of knee joint using cement OS

31977 477 Arthroplasty of knee joint using cement

8006 278 Total prosthetic replacement of knee joint using cement NOS

49053 208 Primary uncemented total knee replacement

9817 193 Uncemented unicompartmental knee replacement

36343 192 Primary cemented unicompartmental knee replacement

58612 145 Total prosthetic replacement knee joint not using cement NOS

54343 113 Primary uncemented unicompartmental knee replacement

37979 112 Other total prosthetic replacement of knee joint OS

101346 61 Prosthetic arthroplasty of the patellofemoral joint

47764 53 Arthroplasty of knee joint not using cement 55470 53 Hybrid unicompartmental knee replacement

61687 33 Attenborough total replacement of knee joint using cement

93344 31 Anametric total replacement of knee joint using cement

37950 29 Primary hybrid unicompartmental knee replacement

50829 29 Total prosthetic replacement knee joint not using cement OS

46475 26 Charnley total replacement of knee joint using cement

54860 24 Freeman total replacement of knee joint using cement

44775 19 Denham total replacement of knee joint using cement

63086 13 Uci total replacement of knee joint using cement

83544 12 Primary hybrid total knee replacement NEC

44926 10 Stanmore total replacement of knee joint using cement

55991 10 Sheehan total replacement of knee joint using cement

49813 7 Deane total replacement of knee joint using cement

47301 6 Polycentric total replacement of knee joint using cement

92246 6 Liverpool total replacement of knee joint using cement

49716 3 Swanson total replacement of knee joint using cement

63802 3 Geomedic total replacement of knee joint using cement

101522 3 Ilch total replacement of knee joint using cement

66707 2 Herbert total replacement of knee joint using cement

71456 2 Cavendish total replacement of knee joint using cement

99912 2 Manchester total replacement of knee joint using cement

101810 2 Wallidus hinge arthroplasty of knee joint using cement

70507 1 Shiers total replacement of knee joint using cement

103334 1 Autophor arthroplasty of knee joint using cement

Total Hip Replacement codes

medcode clinicalevents readterm

394 77247 Total prosthetic replacement of hip joint NOS

2224 35745 THR - Total prosthetic replacement of hip joint using cement

5481 18865 Total prosthetic replacement of hip joint using cement

2734 17051 THR - Other total prosthetic replacement of hip joint

9762 15253 Other total prosthetic replacement of hip joint

1092 11748 Hip joint operations

33439 6920 Primary total prosthetic replacement of hip joint NEC

7288 5163 Hemiarthroplasty of head of femur NEC

589 3566 THR - Total prosthetic replacement hip joint without cement

18442 3291 Total prosthetic replacement of hip joint not using cement

9070 3216 Prosthetic hemiarthroplasty of head of femur using cement

10856 2078 Primary cemented total hip replacement

6681 2027 Austin - Moore hemiarthroplasty of hip joint using cement

18004 1769 Thompson hemiarthroplasty of hip joint using cement

10011 1763 Other arthroplasty of hip joint

16671 1687 Charnley total replacement of hip joint using cement

11846 1212 Hip joint operations NOS

28468 1086 Exeter total replacement of hip joint using cement

29573 1028 Other prosthetic hemiarthroplasty of hip

47483 943 Primary uncemented total hip replacement

17860 830 Arthroplasty of hip joint using cement

38001 791 Total prosthetic replacement of hip joint using cement OS

25300 761 Other specified operations on hip joint

2226 760 Prosthetic cemented hemiarthroplasty of hip NOS

12847 713 Prosthetic cemented hemiarthroplasty of hip

12287 371 Austin Moore hemiarthroplasty of hip joint not using cement

10348 359 Primary hybrid total replacement of hip joint NEC

9739 341 Thompson hemiarthroplasty of hip joint not using cement

15049 326 Other specified other prosthetic hemiarthroplasty of hip 28808 298 Primary prosthetic hemiarthroplasty of hip NEC

47812 287 Total prosthetic replacement of hip joint using cement NOS

41116 281 Primary cemented hemiarthroplasty of hip

7171 276 Prosthetic hemiarthroplasty head of femur not using cement

27448 228 Other prosthetic hemiarthroplasty of hip NOS

37631 209 Other specified total prosthetic replacement of hip joint

38347 198 Total prosthetic replacement hip joint not using cement NOS

29977 174 Stanmore total replacement of hip joint using cement

38332 150 Furlong total replacement of hip joint using cement

43460 143 Prosthetic uncemented hemiarthroplasty of hip

52714 106 Charnley cemented total hip replacement

18818 99 Other arthroplasty of head of femur

6013 98 Muller total replacement of hip joint using cement

36590 93 Howse total replacement of hip joint using cement

71351 88 Aufranc total replacement of hip joint using cement

28022 75 Arthroplasty of head of femur using cement

47735 71 Furlong total replacement of hip joint not using cement

47482 70 Primary uncemented hemiarthroplasty of hip

48955 65 Hastings hemiarthroplasty of hip joint using cement

30019 63 Other replacement of head of femur

21366 55 Bateman hemiarthroplasty of hip joint not using cement

34911 53 Prosthetic cemented replacement of head of femur

61099 47 Monk hemiarthroplasty of hip joint using cement

58651 35 Arthroplasty of head of femur not using cement

10341 32 Total prosthetic replacement hip joint not using cement OS

62092 30 Turner total replacement of hip joint using cement

34997 29 McKee total replacement of hip joint using cement

34383 28 Prosthetic uncemented hemiarthroplasty of hip NOS

47715 28 Monk total replacement of hip joint using cement

55207 23 Primary hybrid total replacement of hip joint NEC 50091 14 Austin Moore hemiarthroplasty of hip joint not using cement

18865 13 Prosthetic replacement head of femur - no cement

52901 13 Freeman total replacement of hip joint using cement

62249 10 Monk hemiarthroplasty of hip joint not using cement

66139 9 Farrer total replacement of hip joint using cement

56215 6 Ilch total replacement of hip joint using cement

73951 5 Ring total replacement of hip joint not using cement

62046 4 Other specified prosthetic uncemented hemiarthroplasty hip

51519 3 Monk total replacement of hip joint not using cement

53109 3 Freeman total replacement of hip joint not using cement

94273 3 Pretoria total replacement of hip joint using cement

96435 1 Lord total replacement of hip joint not using cement

96760 1 Brown hemiarthroplasty of hip joint not using cement

NOACs prodcode therapyevents productname drugsubstancename 39444 5217 Dabigatran etexilate 110mg capsules Dabigatran Etexilate Mesilate 47207 3111 Rivaroxaban 20mg tablets Rivaroxaban 46632 2956 Dabigatran etexilate 150mg capsules Dabigatran Etexilate Mesilate 47353 1296 Rivaroxaban 15mg tablets Rivaroxaban 39119 1084 Rivaroxaban 10mg tablets Rivaroxaban 39503 414 Dabigatran etexilate 75mg capsules Dabigatran etexilate mesilate 39755 400 Pradaxa 110mg capsules (Boehringer Dabigatran Etexilate Ingelheim Ltd) Mesilate 46678 165 Pradaxa 150mg capsules (Boehringer Dabigatran etexilate Ingelheim Ltd) mesilate 39639 45 Xarelto 10mg tablets (Bayer Plc) Rivaroxaban 47925 43 Xarelto 20mg tablets (Bayer Plc) Rivaroxaban 48134 40 Xarelto 15mg tablets (Bayer Plc) Rivaroxaban 42474 30 Pradaxa 75mg capsules (Boehringer Dabigatran etexilate Ingelheim Ltd) mesilate

LMWHs prodcode therapyevents productname drugsubstancename 7307 21628 Clexane 40mg/0.4ml solution for injection pre- filled syringes (Sanofi) 7371 12296 Clexane 100mg/1ml solution for injection pre- Enoxaparin sodium filled syringes (Sanofi) 7199 11848 Enoxaparin sodium 40mg/0.4ml solution for Enoxaparin sodium injection pre-filled syringes 7154 9049 Clexane Forte 120mg/0.8ml solution for injection Enoxaparin sodium pre-filled syringes (Sanofi) 10240 8795 14,000units/0.7ml solution for Tinzaparin sodium injection pre-filled syringes 2676 8274 Fragmin 5,000units/0.2ml solution for injection pre-filled syringes (Pfizer Ltd) 2677 7932 Clexane 100mg/ml Injection (Aventis Pharma) Enoxaparin Sodium 20154 7597 Enoxaparin sodium 100mg/1ml solution for Enoxaparin sodium injection pre-filled syringes 13270 6919 Enoxaparin sodium 120mg/0.8ml solution for Enoxaparin sodium injection pre-filled syringes 10004 6907 Clexane 80mg/0.8ml solution for injection pre- Enoxaparin sodium filled syringes (Sanofi) 13097 6492 Clexane 20mg/0.2ml solution for injection pre- Enoxaparin sodium filled syringes (Sanofi) 9605 6068 Dalteparin sodium 5,000units/0.2ml solution for Dalteparin sodium injection pre-filled syringes 16476 5467 Fragmin 18,000units/0.72ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 6860 5104 Fragmin 15,000units/0.6ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 14341 5100 Clexane Forte 150mg/1ml solution for injection Enoxaparin sodium pre-filled syringes (Sanofi) 14308 4723 Tinzaparin sodium 18,000units/0.9ml solution for Tinzaparin sodium injection pre-filled syringes 5046 4424 Hepsal 50units/5ml patency solution ampoules Heparin sodium (Wockhardt UK Ltd) 14891 4343 Dalteparin sodium 18,000units/0.72ml solution Dalteparin sodium for injection pre-filled syringes 16530 4236 Fragmin 12,500units/0.5ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 14110 4169 Tinzaparin sodium 10,000units/0.5ml solution for Tinzaparin sodium injection pre-filled syringes 13210 4141 Enoxaparin sodium 80mg/0.8ml solution for Enoxaparin sodium injection pre-filled syringes 20153 4058 Enoxaparin sodium 150mg/1ml solution for Enoxaparin sodium injection pre-filled syringes 10170 3984 Dalteparin sodium 15,000units/0.6ml solution for Dalteparin sodium injection pre-filled syringes 4995 3964 Enoxaparin 100mg/ml injection Enoxaparin Sodium 3744 3958 Heparin 10 iu/ml Flush solution Heparin Sodium 6478 3654 Enoxaparin sodium 20mg/0.2ml solution for Enoxaparin sodium injection pre-filled syringes 17664 3621 Clexane 60mg/0.6ml solution for injection pre- Enoxaparin sodium filled syringes (Sanofi) 10194 3284 Dalteparin sodium 12,500units/0.5ml solution for Dalteparin sodium injection pre-filled syringes 14851 2507 Tinzaparin sodium 4,500units/0.45ml solution for Tinzaparin sodium injection pre-filled syringes 5526 2482 Fragmin 2,500units/0.2ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 10072 2224 Fragmin 10,000units/0.4ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 14138 2194 Enoxaparin sodium 60mg/0.6ml solution for Enoxaparin sodium injection pre-filled syringes 14212 2055 Tinzaparin sodium 3,500units/0.35ml solution for Tinzaparin sodium injection pre-filled syringes 9610 1945 Tinzaparin 20000 iu/ml Injection Tinzaparin Sodium 6695 1839 Dalteparin sodium 2,500units/0.2ml solution for Dalteparin sodium injection pre-filled syringes 11372 1754 Heparin 100iu/ml Flush solution Heparin Sodium 10044 1677 Dalteparin sodium 10,000units/0.4ml solution for Dalteparin sodium injection pre-filled syringes 46101 1418 Heparin sodium 50units/5ml patency solution Heparin sodium ampoules 18209 1363 Fragmin 7,500units/0.3ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 9640 1344 Tinzaparin 10000 IU/ml Injection Tinzaparin Sodium 19486 1171 Dalteparin sodium 7,500units/0.3ml solution for Dalteparin sodium injection pre-filled syringes 2675 903 Fragmin 10,000units/4ml solution for injection Dalteparin sodium ampoules (Pfizer Ltd) 5747 862 Fragmin 25,000iu/ml Solution for injection (Pfizer Dalteparin Sodium Ltd) 13663 847 Innohep 20000 iu/ml Injection (LEO Pharma) Tinzaparin Sodium 19280 798 Innohep 14,000units/0.7ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 10533 785 Calciparine 25,000iu/ml Injection (Sanofi- Heparin Calcium Synthelabo Ltd) 10002 771 Dalteparin 10000iu/1ml injection solution Dalteparin Sodium 5998 755 Fragmin 10,000 iu/ml Solution for injection Dalteparin Sodium (Pfizer Ltd) 14099 730 Clexane forte 150mg/ml Injection (Aventis Enoxaparin Sodium Pharma) 11117 717 Hep-flush 100iu/ml Oral solution (LEO Pharma) Heparin Sodium 10469 710 Canusal 200units/2ml patency solution ampoules Heparin sodium (Wockhardt UK Ltd) 17004 649 Tinzaparin sodium 20,000units/2ml solution for Tinzaparin sodium injection vials 13058 570 Enoxaparin 150mg/ml injection Enoxaparin Sodium 9593 560 Dalteparin 25000iu/ml injection solution Dalteparin Sodium 8664 474 Heparin sodium 5000iu/ml Injection Heparin Sodium 14788 474 Innohep 10,000units/0.5ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 17049 434 Innohep 18,000units/0.9ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 10532 406 Minihep calcium 5000iu/0.2ml Injection (LEO Heparin Calcium Pharma) 9140 384 Dalteparin sodium 10,000units/4ml solution for Dalteparin sodium injection ampoules 19989 377 Tinzaparin sodium 40,000units/2ml solution for Tinzaparin sodium injection vials 46278 346 Heparin sodium 200units/2ml patency solution Heparin sodium ampoules 3895 311 Heparin sodium 1000iu/ml Injection Heparin Sodium 17007 288 Tinzaparin sodium 2,500units/0.25ml solution for Tinzaparin sodium injection pre-filled syringes 17592 285 Innohep 4,500units/0.45ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 36989 249 Fragmin 10,000units/1ml solution for injection Dalteparin sodium pre-filled syringes (Pfizer Ltd) 12974 244 Clexane 150mg/ml Injection (Aventis Pharma) Enoxaparin Sodium 17484 233 Innohep 10,000 IU/ml Injection (LEO Pharma) Tinzaparin Sodium 25155 214 Fragmin 100,000units/4ml solution for injection Dalteparin sodium vials (Pfizer Ltd) 16061 199 Innohep 3,500units/0.35ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 36911 185 Fragmin 10,000units/1ml solution for injection Dalteparin sodium ampoules (Pfizer Ltd) 12681 178 Heparin calcium 25,000iu/ml Injection Heparin Calcium 4888 162 Heplok 10 iu/ml Oral solution (LEO Pharma) Heparin Sodium 21233 157 Innohep 20,000units/2ml solution for injection Tinzaparin sodium vials (LEO Pharma) 13568 124 Heparin sodium 25,000iu/ml Subcutaneous Heparin Sodium injection 36172 115 Clexane 300mg/3ml solution for injection Enoxaparin sodium multidose vials (Sanofi) 35033 112 Heparin sodium 5,000units/5ml solution for Heparin sodium injection vials 20029 104 Multiparin 25,000units/5ml solution for injection Heparin sodium vials (Wockhardt UK Ltd) 17791 89 Innohep 5000iu/5ml Sterile solution (LEO Tinzaparin Sodium Pharma) 20024 82 Uniparin forte 10,000 iu/0.4ml Subcutaneous Heparin Sodium injection (C P Pharmaceuticals Ltd) 14794 76 Monoparin 1000iu/ml Injection (C P Heparin Sodium Pharmaceuticals Ltd) 18732 76 Innohep 3500 iu/0.3ml Sterile solution (LEO Tinzaparin Sodium Pharma) 20028 71 Multiparin 5,000units/5ml solution for injection Heparin sodium vials (Wockhardt UK Ltd) 12813 70 3,000units/0.3ml solution for Certoparin sodium injection pre-filled syringes 19337 61 Multiparin 125,000units/5ml solution for Heparin sodium injection vials (Wockhardt UK Ltd) 22428 58 Dalteparin sodium 100,000units/4ml solution for Dalteparin sodium injection vials 21365 53 Uniparin 5000iu/0.2ml Injection (C P Heparin Sodium Pharmaceuticals Ltd) 21490 52 Monoparin 5000iu/ml Injection (C P Heparin Sodium Pharmaceuticals Ltd) 21518 52 Monoparin 25,000iu/ml Injection (C P Heparin Sodium Pharmaceuticals Ltd) 36196 51 Heparin sodium 1,000units/1ml solution for Heparin sodium injection ampoules 37086 49 Enoxaparin sodium 300mg/3ml solution for Enoxaparin Sodium injection vials 13716 48 Heparin sodium 25,000iu/ml Injection Heparin Sodium 21316 43 Innohep 40,000units/2ml solution for injection Tinzaparin sodium vials (LEO Pharma) 33307 43 Heparin sodium 5,000units/1ml solution for Heparin sodium injection ampoules 30108 42 Heparin calcium 5000iu/0.2ml Injection Heparin Calcium 37616 41 Heparin sodium 10 unit/ml Solution Heparin Sodium 37678 35 Heparin sodium 5,000units/0.2ml solution for Heparin sodium injection ampoules 18771 33 Alphaparin 3,000units/0.3ml solution for Certoparin sodium injection pre-filled syringes (Grifols UK Ltd) 20010 28 Uniparin calcium 25,000iu/ml Subcutaneous Heparin Calcium injection (C P Pharmaceuticals Ltd) 15709 27 Tinzaparin 3500 IU/0.3ml Sterile solution Tinzaparin Sodium 36142 23 Heparin sodium 25,000units/1ml solution for Heparin sodium injection ampoules 45597 20 50mg powder for solution for injection Lepirudin vials 35941 19 Heparin sodium 5,000units/5ml solution for Heparin sodium injection ampoules 30396 17 Unihep leo 5000iu/ml Injection (LEO Pharma) Heparin Sodium 27325 15 Innohep 2,500units/0.25ml solution for injection Tinzaparin sodium pre-filled syringes (LEO Pharma) 29317 15 Tinzaparin 5000 i.u./0.5ml Sterile solution Tinzaparin Sodium 32577 15 2,500units/0.2ml solution for Bemiparin sodium injection pre-filled syringes 37613 15 Heparin sodium 10,000units/10ml solution for Heparin sodium injection ampoules 25287 14 Unihep leo 1000unit/ml Injection (LEO Pharma) Heparin Sodium 37131 14 Heparin sodium 25,000units/5ml solution for Heparin sodium injection vials 15293 9 Heparin sodium 5000iu/ml pre-filled Injection Heparin Sodium 26023 9 Bemiparin sodium 3,500units/0.2ml solution for Bemiparin sodium injection pre-filled syringes 35955 9 Calciparine 5,000units/0.2ml solution for Heparin calcium injection pre-filled syringes (Sanofi-Synthelabo Ltd) 25691 7 Clivarine 1,432units/0.25ml solution for injection pre-filled syringes (Valeant Pharmaceuticals Ltd) 37704 7 Minihep 25,000iu/ml Subcutaneous preparation Heparin Sodium (LEO Pharma) 28593 5 Heparin sodium 1000iu/ml pre-filled Injection Heparin Sodium 29318 5 Heparin low molecular weight 2500 iu/ml Sterile Dalteparin Sodium solution 29207 3 Innohep 5000iu/0.5ml Sterile solution (LEO Tinzaparin Sodium Pharma) 31541 3 Heparin calcium 12,500units/0.5ml solution for Heparin calcium injection pre-filled syringes 42106 3 Unihep leo 25,000iu/ml Injection (LEO Pharma) Heparin Sodium 24896 2 Heparin low molecular weight 2500 iu/0.2ml Dalteparin Sodium Sterile solution 25195 2 Heparin sodium 25,000iu/ml pre-filled Injection Heparin Sodium 27035 2 Pump-hep 1000unit/ml Infusion (LEO Pharma) Heparin Sodium 42853 2 Heparin calcium 25,000iu/ml Injection Heparin Calcium 20411 1 Alphaparin 3000iu/0.5ml Injection (Grifols UK Certoparin Sodium Ltd) 26146 1 Heparin low molecular weight 10,000 iu/ml Dalteparin Sodium Sterile solution 28506 1 Heparin low molecular weight 3500 iu/0.3ml Tinzaparin Sodium Sterile solution 32511 1 Tinzaparin 5000 i.u./5ml Sterile solution Tinzaparin Sodium 32575 1 Bemiparin sodium 7,500units/0.3ml solution for Bemiparin sodium injection pre-filled syringes 32645 1 Heparin sodium 25,000iu/ml Injection Heparin Sodium 33558 1 Monoparin calcium 5,000units/0.2ml solution for Heparin calcium injection ampoules (Wockhardt UK Ltd) 40715 1 Heparin 100iu/ml Oral solution (LEO Pharma) Heparin Sodium 44238 1 Heparin 50 iu/5ml Flush solution (Wockhardt UK Heparin Sodium Ltd) 33309 0 Reviparin sodium 1,432units/0.25ml solution for Reviparin sodium injection pre-filled syringes 36617 0 Angiox 250mg powder for solution for injection vials (The Medicines Company UK Ltd) 44491 0 Heparin sodium 125,000units/5ml solution for Heparin sodium injection vials

Aspirin

prodcod therapyevent productname drugsubstancename e s 3 27506575 Aspirin 75mg dispersible tablets Aspirin 34 6222675 Aspirin 75mg gastro-resistant tablets Aspirin 16 5986117 Aspirin 75mg tablets Aspirin 434 880853 Aspirin 300mg gastro-resistant tablets Aspirin 377 632283 Aspirin 300mg dispersible tablets Aspirin 254 427415 Aspirin 300mg tablets Aspirin 1137 151898 Nu-seals aspirin ec 300mg Gastro- Aspirin resistant tablet (Eli Lilly and Company Ltd) 6666 126117 200mg modified-release / Dipyridamole/Aspirin Aspirin 25mg capsules 2628 92124 Nu-seals aspirin ec 75mg Gastro- Aspirin resistant tablet (Eli Lilly and Company Ltd) 31953 20681 Aspirin 75mg dispersible tablets (IVAX Aspirin Pharmaceuticals UK Ltd) 32036 18747 Aspirin 75mg dispersible tablets (Actavis Aspirin UK Ltd) 2924 10637 ASPIRIN 150 MG TAB 9301 5009 Aspirin 100mg modified-release tablets Aspirin 21380 4655 Aspirin 75mg / Isosorbide mononitrate Isosorbide 60mg modified-release tablets mononitrate/Aspirin 9939 4295 Aspirin 500mg effervescent tablets sugar Aspirin free 41512 4134 Aspirin 75mg gastro-resistant tablets Aspirin (Teva UK Ltd) 1486 3907 ASPIRIN 75 MG SUP 10031 3473 Aspirin 25mg with Dipyridamole 200mg Dipyridamole modified-release capsules 395 3166 Aspirin mixture Aspirin 12976 2889 Aspirin 900mg / Metoclopramide 10mg Lysine oral powder sachets sugar free acetylsalicylate/Metocloprami de hydrochloride 216 2810 ASPIRIN 70 MG TAB 657 2648 Aspirin 500mg granules sachets sugar Aspirin free 1049 2618 Nu-seals aspirin 600mg Tablet (Eli Lilly Aspirin and Company Ltd) 7516 2138 Aspirin 300mg effervescent tablets sugar Aspirin free 33656 1516 Aspirin 75mg dispersible tablets (A A H Aspirin Pharmaceuticals Ltd) 8424 1496 ASPIRIN PAED 81 MG TAB 10310 1466 Aspirin powder Aspirin 306 1460 Aspirin with codeine phosphate and Caffeine caffeine tablets 32210 1356 Aspirin 300mg dispersible tablets Aspirin (Actavis UK Ltd) 15364 1209 Aspirin 150mg suppositories Aspirin 111 1145 ASPIRIN 40 MG CAP 31938 1109 Aspirin 75mg gastro-resistant tablets Aspirin (Sandoz Ltd) 12992 951 Aspirin 500mg / Codeine 8mg dispersible Aspirin/Codeine phosphate tablets sugar free 17180 934 Metoclopramide with aspirin 5mg + 450mg Effervescent tablet 4557 900 ASPIRIN & PAPAVERUTUM 10 MG TAB 3726 885 Metoclopramide with aspirin 5mg + Citric Acid 325mg Effervescent tablet 6226 821 Aspirin 500mg / Papaveretum 7.71mg Aspirin/Papaveretum dispersible tablets sugar free 7915 750 ASPIRIN SR 100 MG TAB 8186 741 Aspirin 300mg modified-release tablets Aspirin 7665 733 ASPIRIN SR 300 MG TAB 17926 686 Aspirin 400mg with Codeine 8mg tablets Codeine Phosphate 2754 668 ASPIRIN SOLUBLE 150 MG TAB 39738 657 Aspirin 162.5mg modified-release Aspirin capsules 7518 581 Aspirin 400mg with Codeine 8mg Codeine Phosphate dispersible tablets 34385 578 Aspirin 75mg Soluble tablet (Co- Aspirin operative) 34485 521 Aspirin 75mg gastro-resistant tablets Aspirin (IVAX Pharmaceuticals UK Ltd) 21382 502 Aspirin 150mg / Isosorbide mononitrate Aspirin/Isosorbide 60mg modified-release tablets mononitrate 645 488 Aspirin 300mg suppositories Aspirin 9432 486 Aspirin 500mg / Codeine 8mg soluble Codeine Phosphate tablets 12102 426 ASPIRIN SOLUBLE 100 MG TAB 18217 404 Aspirin 300mg orodispersible tablets Aspirin sugar free 9027 403 ASPIRIN disp 150 MG TAB 8645 400 Aspirin 300mg effervescent tablets Aspirin 31954 363 Aspirin 75mg dispersible tablets (Teva Aspirin UK Ltd) 4271 353 ASPIRIN SOLUBLE 200 MG TAB 8920 342 ASPIRIN SOLUBLE 500 MG TAB 10305 278 Aspirin 162.5mg capsules Aspirin 7989 198 DIHYDROCODEINE TARTRATE/ASPIRIN 300 MG TAB 383 197 ASPIRIN 60 MG TAB 4523 189 ASPIRIN 50 MG CAP 34434 169 Aspirin 75mg dispersible tablets Aspirin (Thornton & Ross Ltd) 3309 153 Aspirin 325mg / Caffeine 15mg tablets Aspirin/Caffeine 8734 152 ASPIRIN disp 37.5 MG TAB 18261 143 Aspirin 500mg with Papaveretum Aspirin 7.71mg dispersible tablets 21770 140 Paracetamol 200mg with aspirin 300mg Paracetamol dispersible tablet 9129 123 Paracetamol 250mg with aspirin 250mg Codeine Phosphate & codeine 6.8mg tablet 15447 123 ASPIRIN SOLUBLE 600 MG TAB 7769 122 ASPIRIN/PARACETAMOL TAB 8381 119 ASPIRIN /CAMPHOR /MENTHOL /METHYL SALICY 1.2 % LIN 15044 119 ASPIRIN disp 500 MG TAB 8733 118 JUNIOR ASPIRIN 37.5 MG TAB 34797 116 Aspirin 75mg gastro-resistant tablets Aspirin (Actavis UK Ltd) 15397 112 ASPIRIN SOLUBLE 50 MG TAB 11326 111 Meprobamate with ethoheptazine Aspirin/ethoheptazine citrate and aspirin Tablet Citrate/meprobamate 20127 100 Codeine phosphate 8mg with aspirin Codeine Phosphate 400mg with caffeine dispersible tablets 32992 97 Aspirin 75mg gastro-resistant tablets Aspirin (Generics (UK) Ltd) 7944 94 ASPIRIN SOLUBLE 40 MG CAP 22138 82 Aspirin 324mg modified-release tablets Aspirin 430 81 Aspirin 500mg / Caffeine 32mg capsules Caffeine 15779 78 Codeine 8mg with aspirin 500mg soluble Codeine Phosphate tablets 26582 72 ASPIRIN PAED 100 MG SUP 19724 71 ASPIRIN & CODEINE paed 75 MG TAB 20650 70 Aspirin 300mg / Paracetamol 200mg Aspirin/Paracetamol dispersible tablets sugar free 7462 61 ASPIRIN 325 MG CAP 34309 59 Aspirin 300mg dispersible tablets (A A H Aspirin Pharmaceuticals Ltd) 31210 56 Aspirin 300mg Tablet (Co-operative) Aspirin 22864 53 ASPIRIN PAED MIX 24622 48 Aspirin 325mg / Caffeine 22mg tablets Aspirin/Caffeine 40381 46 Aspirin 75mg Soluble tablet (C P Aspirin Pharmaceuticals Ltd) 34611 45 Aspirin 75mg gastro-resistant tablets (C Aspirin P Pharmaceuticals Ltd) 11941 44 ASPIRIN SACHETS 30 MG 12964 42 Aspirin 600mg / Caffeine 50mg oral Aspirin/Caffeine powder sachets sugar free 34666 42 Aspirin ec 300mg Gastro-resistant tablet Aspirin (A A H Pharmaceuticals Ltd) 43434 41 Aspirin 300mg gastro-resistant tablets (A Aspirin A H Pharmaceuticals Ltd) 7486 40 ASPIRIN 37.5 MG TAB 22450 40 ASPIRIN & CODEINE 75 MG TAB 22824 39 ASPIRIN disp 600 MG TAB 8843 37 ASPIRIN 325 MG TAB 19577 34 NU-SEALS ASPIRIN 45643 33 Aspirin 75mg Soluble tablet (Celltech Aspirin Pharma Europe Ltd) 33676 31 Aspirin 75mg dispersible tablets (Kent Aspirin Pharmaceuticals Ltd) 22253 28 ASPIRIN paed 150 MG SUP 33668 26 Aspirin 300mg Dispersible tablet (Rusco Aspirin Ltd) 44311 25 DEXTROPROPOXYPHENE NAPSYLATE/ASPIRIN 100 MG TAB 31211 23 Aspirin 75mg Dispersible tablet (A A H Aspirin Pharmaceuticals Ltd) 19674 20 ASPIRIN DISPERSIBLE 26424 20 ASPIRIN 200 MG SUP 27467 20 ASPIRIN SOLUBLE 400 MG TAB 12605 18 ASPIRIN & CAFFEINE disp 300 MG TAB 13598 18 ASPIRIN & CODEINE 500 MG TAB 28238 18 ASPIRIN 300MG/LYSINE 245MG 300 MG TAB 31870 18 Aspirin 320mg tablets Aspirin 34942 18 Aspirin 75mg Dispersible tablet (Nucare Aspirin Plc) 36543 18 Aspirin 100mg effervescent tablets Aspirin 34762 16 Aspirin 300mg Gastro-resistant tablet Aspirin (Galen Ltd) 28810 15 Aspirin 300mg with Glycine 133mg Aspirin soluble tablets 45851 15 Aspirin 300mg Soluble tablet (Ranbaxy Aspirin (UK) Ltd) 15517 14 ASPIRIN 100 MG SUP 24857 14 ASPIRIN 250 MG SUP 30920 14 Aspirin 300mg Dispersible tablet (M & A Aspirin Pharmachem Ltd) 7770 13 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 250 MG TAB 29054 13 Methocarbamol with aspirin Tablet Methocarbamol 28606 12 ASPIRIN/CAFFEINE/CODEINE PHOSPHATE 300 MG TAB 22107 11 ASPIRIN disp 200 MG TAB 36521 11 Aspirin 500mg modified-release tablets Aspirin 24427 9 ANHYDROUS CITRIC ACID /ASPIRIN /CALCIUM 8 MG TAB 45840 9 Aspirin 300mg Dispersible tablet Aspirin (Numark Management Ltd) 7417 8 ASPIRIN 40 MG TAB 15352 8 ASPIRIN & PARACETAMOL TAB 23250 7 ASPIRIN /ETHOHEPTAZINE CITRATE /MEPROBAM 250 MG TAB 31956 7 Aspirin 75mg gastro-resistant tablets Aspirin (Kent Pharmaceuticals Ltd) 42061 7 ASPIRIN 65 MG SUP 43709 7 Aspirin 75mg gastro-resistant tablets Aspirin (Almus Pharmaceuticals Ltd) 19255 6 Paracetamol 200mg with aspirin 300mg Caffeine & caffeine 45mg tablet 24498 6 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 300 MG TAB 26099 6 ASPIRIN 175 MG SUP 28707 6 ASPIRIN M/F 324 MG TAB 41594 6 Aspirin 300mg Dispersible tablet (Teva Aspirin UK Ltd) 21932 5 ETHOHEPTALINE CITRATE/ASPIRIN MG TAB 28784 5 Codeine phosphate 8mg with aspirin Codeine Phosphate 400mg tablets 34796 5 Aspirin 75mg Gastro-resistant tablet Aspirin (Galen Ltd) 53178 5 Aspirin 75mg gastro-resistant tablets Aspirin (Wockhardt UK Ltd) 29848 4 Aspirin 300mg with Glycine 150mg Aspirin chewable tablets 33075 4 ASPIRIN 600MG/GLYCINE 300MG 600 MG TAB 43806 4 Aspirin 300mg gastro-resistant tablets Aspirin (Sandoz Ltd) 11951 3 Original Phensic Aspirin tablets (Merck Aspirin/Caffeine Consumer Health Products) 19813 3 ASPIRIN SOLUBLE 22776 3 Aspirin 500mg with Cyclizine 25mg Cyclizine Hydrochloride effervescent tablets 23491 3 ASPIRIN 500 MG SUP 25959 3 ASPIRIN/CAFFEINE/DEXTROPROPOXYPH ENE NAPS PUL 30022 3 Fynnon calcium aspirin 500mg Soluble Calcium Carbonate tablet (SSL International Plc) 33320 3 Aspirin 75mg Dispersible tablet Aspirin (Sovereign Medical Ltd) 33662 3 Aspirin 300mg Dispersible tablet (A A H Aspirin Pharmaceuticals Ltd) 34233 3 Aspirin with and caffeine Caffeine capsules 40191 3 ASPIRIN /CAFFEINE /QUININE SULPHATE 325 MG TAB 20206 2 ASPIRIN 50 MG SUP 24309 2 Paracetamol 120mg with aspirin Caffeine 165.3mg & caffeine 60mg powder 26792 2 ASPIRIN 125 MG SUP 30432 2 ASPIRIN & DOVER'S pwdr TAB 31498 2 ASPIRIN / CAFFEINE CIT./ CODEINE PHOS./ 200 MG TAB 40144 2 Aspirin 300mg Dispersible tablet Aspirin (Thornton & Ross Ltd) 52044 2 Aspirin 300mg caplets (The Boots Aspirin Company Plc) 19797 1 NU-SEALS ASPIRIN 22863 1 ASPIRIN S/R 500 MG TAB 23495 1 ASPIRIN 27435 1 Paracetamol 200mg with aspirin 300mg Caffeine & caffeine 45mg soluble tablet 30695 1 ASPIRIN 120 MG SUP 31499 1 Paracetamol with aspirin tablet Paracetamol 32178 1 Paracetamol 133mg with aspirin 267mg Caffeine & caffeine 40mg effervescent tablet 33293 1 Aspirin 75mg gastro-resistant tablets Aspirin (Sterwin Medicines) 33317 1 Aspirin with Sodium bicarbonate with Citric Acid Citric acid effervescent tablets 34386 1 Aspirin 300mg tablets (Actavis UK Ltd) Aspirin 41569 1 Aspirin 300mg tablets (A A H Aspirin Pharmaceuticals Ltd) 43060 1 Aspirin 300mg Soluble tablet (Celltech Aspirin Pharma Europe Ltd) 44639 1 Aspirin 300mg Dispersible tablet (Nucare Aspirin Plc) 48974 1 Aspirin 75mg tablets (Phoenix Aspirin Healthcare Distribution Ltd) 50555 1 Aspirin 300mg dispersible tablets Aspirin (Doncaster Pharmaceuticals Ltd) 24960 0 Aspirin 300mg tablets (Vantage) Aspirin 32314 0 Aspirin with aloxiprin and caffeine Caffeine powder 37541 0 Aspirin 227mg medicated chewing-gum Aspirin 47937 0 Aspirin 75mg dispersible tablets Aspirin (Wockhardt UK Ltd) 47992 0 Aspirin 75mg gastro-resistant tablets (A Aspirin A H Pharmaceuticals Ltd) 48000 0 Aspirin 300mg tablets (Sigma Aspirin Pharmaceuticals Plc) 48021 0 Aspirin 75mg Tablet (Hillcross Aspirin Pharmaceuticals Ltd) 48165 0 Aspirin 300mg tablets (Aspar Aspirin Pharmaceuticals Ltd) 49060 0 Aspirin 75mg dispersible tablets (Alliance Aspirin Healthcare (Distribution) Ltd) 49220 0 Aspirin 300mg tablets (Kent Aspirin Pharmaceuticals Ltd) 49685 0 Aspirin 75mg dispersible tablets (Sigma Aspirin Pharmaceuticals Plc) 49799 0 Aspirin 150mg suppositories (A A H Aspirin Pharmaceuticals Ltd) 50926 0 Aspirin 75mg dispersible tablets (The Aspirin Boots Company Plc) 50949 0 Aspirin 75mg tablets (A A H Aspirin Pharmaceuticals Ltd) 51474 0 Aspirin 150mg suppositories (Martindale Aspirin Pharmaceuticals Ltd) 51561 0 Aspirin 75mg gastro-resistant tablets Aspirin (Zanza Laboratories Ltd) 52280 0 Aspirin 300mg Tablet (Wockhardt UK Aspirin Ltd) 52618 0 Aspirin 75mg dispersible tablets (Bristol Aspirin Laboratories Ltd) 52905 0 Aspirin 300mg tablets (Lloyds Pharmacy Aspirin Ltd) 53622 0 Aspirin 300mg Tablet (M & A Aspirin Pharmachem Ltd) 53711 0 Aspirin 300mg Tablet (Nucare Plc) Aspirin 53791 0 Aspirin 150mg suppositories (Alliance Aspirin Healthcare (Distribution) Ltd) 53804 0 Aspirin 300mg gastro-resistant tablets Aspirin (Alliance Healthcare (Distribution) Ltd) 53816 0 Aspirin 300mg dispersible tablets Aspirin (Alliance Healthcare (Distribution) Ltd) 54284 0 Aspirin 75mg dispersible tablets (Almus Aspirin Pharmaceuticals Ltd) 54430 0 Aspirin 75mg tablets (Alliance Aspirin Healthcare (Distribution) Ltd) 54526 0 Aspirin 300mg tablets (Alliance Aspirin Healthcare (Distribution) Ltd) 54565 0 Aspirin 75mg dispersible tablets (Lloyds Aspirin Pharmacy Ltd) 54734 0 Aspirin 300mg tablets (Wockhardt UK Aspirin Ltd) 54997 0 Aspirin 75mg dispersible tablets Aspirin (Dowelhurst Ltd) 55230 0 Aspirin 300mg dispersible tablets (Kent Aspirin Pharmaceuticals Ltd) 55579 0 Aspirin 300mg tablets (Almus Aspirin Pharmaceuticals Ltd)

Table 3: Drug use according to identification method

Drug use TKR THR

Free tekst Product codes Free tekst Product codes

(%) (%) (%) (%)

All 36 64 36 64

NOAC 81 19 82 18

LMWH 70 30 66 34

Aspirin 12 88 12 88

TKR = Total Knee Replacement, THR = Total Hip Replacement, NOAC = New Oral , LMWH = Low Molecular Weight