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Remedy and Elimination of Tuberculosis” Akanksha Mishra [email protected]
The University of San Francisco USF Scholarship: a digital repository @ Gleeson Library | Geschke Center Master's Theses Theses, Dissertations, Capstones and Projects Winter 12-15-2017 A Novel Model of “Remedy and Elimination of Tuberculosis” Akanksha Mishra [email protected] Follow this and additional works at: https://repository.usfca.edu/thes Part of the Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Diseases Commons, Epidemiology Commons, International Public Health Commons, and the Other Medicine and Health Sciences Commons Recommended Citation Mishra, Akanksha, "A Novel Model of “Remedy and Elimination of Tuberculosis”" (2017). Master's Theses. 1118. https://repository.usfca.edu/thes/1118 This Thesis is brought to you for free and open access by the Theses, Dissertations, Capstones and Projects at USF Scholarship: a digital repository @ Gleeson Library | Geschke Center. It has been accepted for inclusion in Master's Theses by an authorized administrator of USF Scholarship: a digital repository @ Gleeson Library | Geschke Center. For more information, please contact [email protected]. A Novel Model of “Remedy and Elimination of Tuberculosis” By: Akanksha Mishra University of San Francisco November 21, 2017 MASTER OF ARTS in INTERNATIONAL STUDIES 1 ABSTRACT OF THE DISSERTATION A Novel Model of “Remedy and Elimination of Tuberculosis” MASTER OF ARTS in INTERNATIONAL STUDIES By AKANKSHA MISHRA December 18, 2017 UNIVERSITY OF SAN FRANCISCO Under the guidance and approval of the committee, and approval by all the members, this thesis project has been accepted in partial fulfillment of the requirements for the degree. Adviser__________________________________ Date ________________________ Academic Director Date ________________________________________ ______________________ 2 ABSTRACT Tuberculosis (TB), is one of the top ten causes of death worldwide. -
The Rise and Fall of the Tuberculosis Sanitarium in Response to the White Plague a Thesis Submitted to the Graduate School In
THE RISE AND FALL OF THE TUBERCULOSIS SANITARIUM IN RESPONSE TO THE WHITE PLAGUE A THESIS SUBMITTED TO THE GRADUATE SCHOOL IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE MASTER OF SCIENCE HISTORIC PRESERVATION BY ANYA GRAHN (EDWARD WOLNER) BALL STATE UNIVERSITY MUNCIE, INDIANA MAY 2012 Acknowledgements This thesis would not have been possible without the support and encouragement of my thesis committee. I must first thank Architecture Professor Edward Wolner for his patience with me, his guidance, and for sharing his wealth of knowledge about modernist architecture and architects, Johannes Duiker and Alvar Aalto, in particular. Secondly, I am incredibly grateful to History Professor Nina Mjagkij, a former consumptive, for directing my research and organization of this thesis. Finally, I am appreciative of Architecture instructor Cynthia Brubaker’s support of my initial research, eagerness to learn more about tuberculosis sanitariums, and willingness to serve on this committee. I am also thankful to my MSHP colleagues Emily Husted, Kelli Kellerhals, and Chris Allen. The four of us formed a student thesis committee, meeting weekly to set goals for our research and writing, discussing our topics, and keeping one another on task. It is very possible that this thesis would not have been completed without them. I would also like to acknowledge the help provided to me in researching Kneipp Springs Sanitarium. Bridgett Cox at the Hope Springs Library was very helpful, responding to my email requests and introducing me to the Scrapbooks of M.F. Owen: Rome City Area History that played such a pivotal role in my research of this institution. -
Life in the Open Air: the Persistence of Outdoor Air Treatment for Pulmonary
James Madison University JMU Scholarly Commons Masters Theses The Graduate School Spring 2011 Life in the open air: The persistence of outdoor air treatment for pulmonary tuberculosis patients in America from the Industrial Revolution to the 1950s Tara Darlene Mastrangelo James Madison University Follow this and additional works at: https://commons.lib.jmu.edu/master201019 Part of the History Commons Recommended Citation Mastrangelo, Tara Darlene, "Life in the open air: The persistence of outdoor air treatment for pulmonary tuberculosis patients in America from the Industrial Revolution to the 1950s" (2011). Masters Theses. 268. https://commons.lib.jmu.edu/master201019/268 This Thesis is brought to you for free and open access by the The Graduate School at JMU Scholarly Commons. It has been accepted for inclusion in Masters Theses by an authorized administrator of JMU Scholarly Commons. For more information, please contact [email protected]. Life in the Open Air: The Persistence of Outdoor Air Treatment for Pulmonary Tuberculosis Patients in America from the Industrial Revolution to the 1950s Tara Mastrangelo A thesis submitted to the Graduate Faculty of JAMES MADISON UNIVERSITY In Partial Fulfillment of the Requirements for the degree of Master of Arts History May 2011 Acknowledgements First and foremost, I would like to express appreciation for my thesis advisor, Dr. Raymond M. Hyser, for all of his guidance, enthusiasm, and support during the thesis writing process and in general. Despite having many advisees he was always willing to make time to meet, for which I am extremely grateful. He urged me on with patience and humor every step of the way. -
Tuberculosis Transcriptomics
Tuberculosis Transcriptomics: Host Protection and ImmuneTown Evasion Mechanisms Cape of Mumin OZTURK Thesis submitted to the University of Cape Town in fulfillment of the University degree Doctor of Philosophy Cytokines and Disease Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. The copyright of this thesis vests in the author. No quotation from it or information derived from it is to be published without full acknowledgement of the source. The thesis is to be used for private study or non- commercial research purposes only. Published by the University of Cape Town (UCT) in terms of the non-exclusive license granted to UCT by the author. University of Cape Town TABLE OF CONTENTS ACKNOWLEDGEMENTS……………………………………………………………………….4 ABSTRACT……………………………………………………………………………………….5 LIST OF PUBLICATIONS………………………………………………………………………..6 LIST OF ABBREVIATIONS……………………………………………………………………..7 CHAPTER I LITERATURE REVIEW…………………………………………………………...9 1.1 HISTORY of TUBERCULOSIS………………………………………………………9 1.2 TUBERCULOSIS: CURRENT SITUATION and INSIGHTS……………………...15 1.3 TUBERCULOSIS IMMUNOPATHOLOGY……………………………………….16 1.4 MTB AND MACROPHAGE INTERPLAY………………………………………...21 CHAPTER II TRANSCRIPTOMICS OF MTB INFECTED MACROPHAGES………………29 2.1 ROLE OF FUNCTIONAL GENOMICS TO UNDERSTAND IMMUNE RESPONSES ……………………………………………………………………………29 2.2 CAP ANALYSIS GENE EXPRESSION -
Fuelling Drug Discovery Against Mycobacterium Tuberculosis
More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis THÈSE NO 8906 (2018) PRÉSENTÉE LE 5 OCTOBRE 2018 À LA FACULTÉ DES SCIENCES DE LA VIE UNITÉ DU PROF. COLE PROGRAMME DOCTORAL EN BIOTECHNOLOGIE ET GÉNIE BIOLOGIQUE ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE POUR L'OBTENTION DU GRADE DE DOCTEUR ÈS SCIENCES PAR Shi-Yan Caroline FOO acceptée sur proposition du jury: Prof. M. Blokesch, présidente du jury Prof. S. Cole, directeur de thèse Prof. P. Sander, rapporteur Prof. M. Jackson, rapporteuse Prof. K.-H. Altmann, rapporteur Suisse 2018 Summary Tuberculosis (TB), whose etiological agent is Mycobacterium tuberculosis (M. tuberculosis), has plagued humanity since antiquity. Even with chemotherapy available today, TB is the leading cause of death due to an infectious disease. Modern day factors, such as the HIV epidemic and the emergence of drug-resistant TB strains, have redefined the complexities and challenges of tackling the TB pandemic. Current treatments for TB are lengthy, and poor adherence to such prolonged treatment further exacerbates the issue of drug resistance. Moreover, therapies for drug-resistant TB have low cure rates. There is therefore a pressing need for improved therapies that are short and efficacious against all TB strains, which can be achieved through new antimicrobials that are more potent and have novel mechanisms of action, in addition to being affordable, orally bioavailable, and without drug-drug interactions. Such new anti-TB drugs need to be discovered and developed through a long, risky, and costly process, in which attrition rates are high. While there are promising compounds currently being developed, including the benzothiazinones (BTZs), it is necessary to further populate and enhance the Global TB drug pipeline to ensure the availability of new drugs. -
This Form Is for Use in Documenting Multiple Property Groups Relating to One Or Several Historic Contexts
r r ua . 1024-0018 NATIONAL OF HISTORIC PLACES This form is for use in documenting multiple property groups relating to one or several historic contexts. See instructions in Guidelines for Completing National Register Forms (National Register Bulletin 16) . Complete each item by marking "x" in the appropriate box or by entering the requested information. For additional space use continuation sheets (Form 10-900-a) . Type all entries. A Mame of Maltipi** Piryertv Idli and Franklin. OO», NY B. Associated Historic Gnnbexts lake, MY 1873 - 1940 iphical Data Generally, the boundaries of the incorporated village of Saranac Lake, Essex and Franklin Counties, New York. [ ] See continuation sheet D. As the designated authority under the National Historic Preservation Act of 1966, as amended, I hereby certify that this documentation form meets the National Register documentation standards and sets forth requirements for listing of related properties consistent with the National Register criteria. This submission meets the procedural and professional requirements set forth in 36 CFR Part 60 and the Secretary of the :iorf s Standards for banning and Evaluation. Commissioner for Historic Preservation Si of certifying official New York State Office of Parks, Recreation and Historic Preservation State or Federal agency and bureau I, hereby, certify that this multiple property documentation form has been approved by the National Register as. a basis for evaluating related properties for listing in the of the^^ational Register Date Discuss each historic context listed in section B. The dense urban streetscape of the village of Saranac Lake, New York, is a marked contrast to the vast stretches of unpopulated forest and tiny isolated hamlets which exist in the Adirondack region. -
The Never-Ending Story of the Fight Against Tuberculosis: from Koch's
J PREV MED HYG 2018; 59: E120-E126 ORIGINAL ARTICLE The never-ending story of the fight against tuberculosis: from Koch’s bacillus to global control programs M. MARTINI1 2, G. BESOZZI3 4, I. BARBERIS1 1 University of Genoa, Department of Health Sciences, Section of Medical History and Ethics, Genoa, Italy; 2 UNESCO CHAIR Anthropology of Health - Biosphere and Healing System, University of Genoa, Genoa, Italy, 3 Centro di Formazione TB Italia Onlus; 4 Istituto Villa Marelli, Milano Keywords History of tuberculosis • Bacille Calmette Guerìn • Mycobacterium tuberculosis • Tuberculosis control strategy Summary Tuberculosis (TB) is one of the oldest diseases known to affect sanatorium, which proved to be one of the first useful measures humanity, and is still a major public health problem. It is against TB. Subsequently, Albert Calmette and Camille Gué- caused by the bacillus Mycobacterium tuberculosis (MT), iso- rin used a non-virulent MT strain to produce a live attenuated lated in 1882 by Robert Koch. Until the 1950s, X rays were vaccine. In the 1980s and 1990s, the incidence of tuberculosis used as a cheap method of diagnostic screening together with surged as a major opportunistic infection in people with HIV the tuberculin skin sensitivity test. In the diagnosis and treat- infection and AIDS; for this reason, a combined strategy based ment of TB, an important role was also played by surgery. The on improving drug treatment, diagnostic instruments and pre- late Nineteenth century saw the introduction of the tuberculosis vention was needed. Introduction and historical approach disease transmitted by an infectious agent, Mycobacte- rium tuberculosis [7]. -
Well Built in Albuquerque: the Architecture of the Healthseeker Era, 1900-1940 Kristen Reynolds
University of New Mexico UNM Digital Repository History ETDs Electronic Theses and Dissertations 2-8-2011 Well Built in Albuquerque: The Architecture of the Healthseeker Era, 1900-1940 Kristen Reynolds Follow this and additional works at: https://digitalrepository.unm.edu/hist_etds Recommended Citation Reynolds, Kristen. "Well Built in Albuquerque: The Architecture of the Healthseeker Era, 1900-1940." (2011). https://digitalrepository.unm.edu/hist_etds/67 This Thesis is brought to you for free and open access by the Electronic Theses and Dissertations at UNM Digital Repository. It has been accepted for inclusion in History ETDs by an authorized administrator of UNM Digital Repository. For more information, please contact [email protected]. WELL BUILT IN ALBUQUERQUE: THE ARCHITECTURE OF THE HEALTHSEEKER ERA, 1900-1940 BY KRISTEN REYNOLDS B.A., English, Boston College, 1993 THESIS Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts History The University of New Mexico Albuquerque, New Mexico December, 2010 ii ACKNOWLEDGMENTS I extend heartfelt thanks to my advisor, Dr. Cathleen Cahill, for sheperding me through this transformative process. Dr. Cahill has been a wonderful teacher, and I am grateful to have benefited from her immense skills as both a scholar and an editor. I also extend gratitude to my other thesis committee members: Dr. Andrew Sandoval-Strausz and Dr. Chris Wilson. Drs. Sandoval-Strausz and Wilson—both masters in the fields of vernacular architecture and cultural landscape studies—offered valuable insights, comments, and suggestions that strengthened this work. In addition, I would like to thank Dr. Durwood Ball, under whose tutelage at the New Mexico Historical Review I gained valuable writing and editing skills. -
Discovery, Characterization and Structural Studies of Inhibitors Against Mycobacterium Tuberculosis Adenosine Kinase and Biotin
DISCOVERY, CHARACTERIZATION AND STRUCTURAL STUDIES OF INHIBITORS AGAINST MYCOBACTERIUM TUBERCULOSIS ADENOSINE KINASE AND BIOTIN PROTEIN LIGASE A Dissertation by ROBERTO A. CRESPO MORALES Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Chair of Committee, James C. Sacchettini Committee Members, Jean-Philippe Pellois David Peterson Tadhg Begley Head of Department, Gregory Reinhart December 2017 Major Subject: Biochemistry Copyright 2017 Roberto A. Crespo Morales ABSTRACT The rapid emergence of drug-resistant Mycobacterium tuberculosis (Mtb) coupled to the high incidence of HIV-Mtb coinfection is of global concern. Consequently, there is a worldwide necessity to develop new drugs with novel mechanisms of action and new molecular targets. In this dissertation, we describe a crystallographic and high-throughput screening (HTS) approach towards the identification and structural characterization of inhibitors against Mycobacterium tuberculosis adenosine kinase (MtbAdoK) and biotin protein ligase (MtbBpL). Parallel studies were also performed to evaluate the in vitro potency and antimycobacterial profile of the compounds. Finally, X-ray crystallography was employed to investigate the structural basis of inhibition and to perform structure- guided drug design. In the first study, we focused on the biochemical, chemical synthesis and structural characterization of adenosine analogs as inhibitors of MtbAdoK. Here, we adopted a bottom-up structural approach towards the discovery, design, and synthesis of a series of compounds that displayed inhibitory constants ranging from 4.3-121.0 nM against the enzyme. Two of these compounds exhibited low micromolar activity against Mtb with 50.0 % minimum inhibitory concentrations of 1.7 and 4.0 µM. -
Tuberculosis and Cancer in European and North American Literature
Writing Illness: Tuberculosis and Cancer in European and North American Literature DISSERTATION Presented in Partial Fulfillment for the Degree of Doctor of Philosophy in the Graduate School of The Ohio State University By Kristen M. Hetrick, B.A., M.A. Graduate Program in Germanic Languages and Literatures The Ohio State University 2012 Committee Members: Helen Fehervary, Advisor Barbara Becker-Cantarino Gregor Hens Copyright by Kristen M. Hetrick 2012 Abstract This dissertation addresses the use of two of the great scourges in world history, tuberculosis and cancer, in the literary texts of North America and Europe. The focus of this work is on these two diseases due to their prominent status in the western world over the last several centuries. They also possess several significant commonalities: each has held the distinction of being one of the most feared diseases, each has been responsible for the deaths of countless people, and each has had a significant literary presence in Europe and North America. I first provide a chapter on each disease detailing its biological, medical, and social histories. Each chapter on the literary texts then includes discussions of noteworthy examples from a wide range of cultures in this investigation of each disease’s three primary manifestations in literature. The longer focused analyses of each paradigm concentrate on works from Germany and North America, as these literary traditions have produced particularly compelling works concerning tuberculosis and cancer. These focused analyses concern use of tuberculosis in the texts of Erich Maria Remarque, Eugene O’Neill, and Thomas Mann, and the use of cancer in the works of Brigitte Reimann, Maxie Wander, Audre Lorde, Reynolds Price, Thomas Mann, Margaret Atwood, Margaret Edson, and Christa Wolf. -
Mycobacterial Cell Wall: a Source of Successful Targets for Old and New Drugs
applied sciences Review Mycobacterial Cell Wall: A Source of Successful Targets for Old and New Drugs Catherine Vilchèze Einstein College of Medicine, 1301 Morris Park Avenue, the Bronx, New York, NY 10461, USA; [email protected] Received: 27 February 2020; Accepted: 19 March 2020; Published: 27 March 2020 Abstract: Eighty years after the introduction of the first antituberculosis (TB) drug, the treatment of drug-susceptible TB remains very cumbersome, requiring the use of four drugs (isoniazid, rifampicin, ethambutol and pyrazinamide) for two months followed by four months on isoniazid and rifampicin. Two of the drugs used in this “short”-course, six-month chemotherapy, isoniazid and ethambutol, target the mycobacterial cell wall. Disruption of the cell wall structure can enhance the entry of other TB drugs, resulting in a more potent chemotherapy. More importantly, inhibition of cell wall components can lead to mycobacterial cell death. The complexity of the mycobacterial cell wall offers numerous opportunities to develop drugs to eradicate Mycobacterium tuberculosis, the causative agent of TB. In the past 20 years, researchers from industrial and academic laboratories have tested new molecules to find the best candidates that will change the face of TB treatment: drugs that will shorten TB treatment and be efficacious against active and latent, as well as drug-resistant TB. Two of these new TB drugs block components of the mycobacterial cell wall and have reached phase 3 clinical trial. This article reviews TB drugs targeting the mycobacterial cell wall in use clinically and those in clinical development. Keywords: tuberculosis; discovery; mode of action; drug resistance; toxicity; target 1. -
Tuberculosis Tuberculosis (TB) Is an Infectious Disease Usually Caused by Mycobacterium Tuberculosis (MTB) Bacteria
Tuberculosis Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body.[1] Most infections do not have symptoms, in which case it is known as latent tuberculosis. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those affected.[1] The classic symptoms of active TB are a chronic cough with blood- containing sputum, fever, night sweats, and weight loss.[1] It was historically called "consumption" due to the weight loss. Infection of other organs can cause a wide range of symptoms. Tuberculosis is spread through the air when people who have active TB in their lungs cough, spit, speak, or sneeze. People with latent TB do not spread the disease.[1] Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis of active TB is based on chest X- rays, as well as microscopic examination and culture of body fluids.[11]Diagnosis of latent TB relies on the tuberculin skin test (TST) or blood tests.[ Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin (BCG) vaccine. Those at high risk include household, workplace, and social contacts of people with active TB.[ Treatment requires the use of multiple antibiotics over a long period of time.[1] Antibiotic resistance is a growing problem with increasing rates of multiple drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).