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EUROPEAN RESPIRATORY Impact factor: journal 5.992 CHIEF EDITORS Anh Tuan Dinh-Xuan Vito Brusasco CONTENTS Dept of Cardiorespiratory Dept of Internal Medicine, Medicine, Medical School, VOLUME 39 / NUMBER 6 / JUNE 2012 Cochin Hospital, University of Genoa, University Paris Descartes, viale Benedetto XV, 6, 27, rue du faubourg 16132 Genoa, Saint-Jacques, Italy IN MEMORIAM 75014 Paris, Tel: 39 0103537690 France Fax: 39 0103537690 1283 Prof. Andrzej Szczeklik, 1938–2012: aspirin-induced Tel: 33 158412341 E-mail: [email protected] asthma and much more Fax: 33 158412345 Sven-Erik Dahlén, Barbro Dahlén and Klaus F. Rabe; E-mail: [email protected] Ewa Nizankowska-Mogilnicka, Jacek Musial, Marek Sanak and Piotr Gajewski ASSISTANT TO THE CHIEF EDITORS Sy Duong-Quy Tel: 33 158411942 Fax: 33 158412345 EDITORIALS E-mail: [email protected] 1287 Bronchoscopic lung volume reduction for emphysema: PUBLICATIONS OFFICE where next? Managing Editors: Elin Reeves and Neil Bullen Pallav L. Shah and Nicholas S. Hopkinson 442 Glossop Road, Sheffi eld, S10 2PX, UK 1290 Multidrug-resistant tuberculosis in Eastern Europe: still Tel: +44 114 267 2860 Fax: +44 114 266 5064 on the increase? E-mail: [email protected]/[email protected] Giovanni Battista Migliori, Masoud Dara, Pierpaolo de Colombani, Hans Kluge and Mario C. Raviglione ASSOCIATE EDITORS N. Ambrosino J. Müller-Quernheim 1292 Pre-implantation genetic testing for hereditary pulmonary Pisa, Italy Freiburg, Germany arterial hypertension: promise and caution I. Annesi-Maesano R. Naeije Rizwan Hamid and James Loyd Paris, France Brussels, Belgium J.L. Black M.I. Polkey 1294 Respiratory critical care HERMES syllabus: defining Sydney, Australia London, UK competencies for respiratory doctors Antonio Artigas, Paolo Pelosi, Dominic Dellweg, Laurent P. Chanez G. Raghu Marseille, France Seattle, USA Brochard, Miguel Ferrer, Jens Geiseler, Anders Larsson, V. Cottin Stefano Nava, Paolo Navalesi, Julie-Lyn Noël, Stylianos Lyon, France M. Saetta Orfanos, Paolo Palange, Bernd Schoenhofer, Theodoros Padova, Italy L.M. Fabbri Vassilakopoulos and Anita Simonds, the ERS Educational Modena, Italy J-P. Sculier Task Force on Respiratory Critical Care HERMES Brussels, Belgium R. Farré Barcelona, Spain F. Sériès PERSPECTIVE U. Frey Quebec City, Canada Basel, Switzerland P.D. Sly 1298 Evasion of COPD in smokers: at what price? J. Gerritsen Brisbane, Australia Manuel G. Cosio and Marina Saetta Groningen, the Netherlands J.B. Soriano P. Hiemstra Bunyola, Spain Leiden, the Netherlands A. Torres ORIGINAL ARTICLES M.M. Hoeper Barcelona, Spain Hanover, Germany P.E. Van Schil Occupational lung disease M. Humbert Edegem, Belgium Clamart, France T. Welte 1304 Temporal patterns of occupational asbestos exposure and S. Kawut Hanover, Germany risk of pleural mesothelioma Philadelphia, USA M.A. Woodhead Aude Lacourt, Karen Leffondré, Céline Gramond, Stéphane P. Lévy Manchester, UK Ducamp, Patrick Rolland, Anabelle Gilg Soit Ilg, Marie Grenoble, France S.G. Zakynthinos Houot, Ellen Imbernon, Joëlle Févotte, Marcel Goldberg G.B. Migliori and Patrick Brochard Tradate, Italy Athens, Greece ADVISORS Telemedicine and spirometry P-Y. Brillet A. Kettaneh S. Suissa Bobigny, France Paris, France Montreal, Canada 1313 Telemedicine enhances quality of forced spirometry in Radiology Statistics Methodology primary care Felip Burgos, Carlos Disdier, Elena Lopez de Santamaria, INTERNATIONAL ADVISORY BOARD Batxi Galdiz, Núria Roger, Maria Luisa Rivera, Ramona M.G. Belvisi C.E. Mapp Hervàs, Enric Durán-Tauleria, Judith Garcia-Aymerich and London, UK Ferrara, Italy Josep Roca, on behalf of e-Spir@p group E. Berglund E. Michelakis Gothenburg, Sweden Edmonton, Canada COPD C. Brambilla B. Nemery Grenoble, France Leuven, Belgium 1319 Multicentre European study for the treatment of advanced P.M.A. Calverley P. Palange emphysema with bronchial valves Liverpool, UK Rome, Italy Vincent Ninane, Christian Geltner, Michela Bezzi, E. Canalis K.F. Rabe Pierfranco Foccoli, Jens Gottlieb, Tobias Welte, Luis Seijo, Barcelona, Spain Kiel, Germany Javier J. Zulueta, Mohammed Munavvar, Antoni Rosell, U. Costabel R. Rodriguez-Roisin Marta Lopez, Paul W. Jones, Harvey O. Coxson, Steven Essen, Germany Barcelona, Spain C. Springmeyer and Xavier Gonzalez M. Decramer A.M.W.J. Schols Leuven, Belgium Maastricht, the Netherlands 1326 Bronchoscopic thermal vapour ablation therapy in the R. Djukanovic N. Siafakas management of heterogeneous emphysema Southampton, UK Heraklion, Greece Gregory Snell, Felix J.F. Herth, Peter Hopkins, Kimberley O. Eickelberg A.K. Simonds M. Baker, Christian Witt, Mark H. Gotfried, Arschang Munich, Germany London, UK Valipour, Manfred Wagner, Franz Stanzel, Jim J. Egan, S. Ewig P.J. Sterk Steven Kesten and Armin Ernst Bochum, Germany Amsterdam, the Netherlands P.N. Le Souëf N.S. Zhong Perth, Australia Guangzhou, China ORIGINAL ARTICLES (CONT.) EUROPEAN 1334 Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort Felix J.F. Herth, Marc Noppen, Arschang Valipour, Sylvie RESPIRATORY Leroy, Jean-Michel Vergnon, Joachim H. Ficker, Jim J. Egan, Stefano Gasparini, Carlos Agusti, Debby Holmes- Higgin and Armin Ernst, on behalf of the International journal VENT Study Group AIMS & SCOPE 1343 Risk factors for COPD spirometrically defined from the The European Respiratory Journal (ERJ), the offi cial Journal lower limit of normal in the BOLD project of the European Respiratory Society, publishes, in the Richard Hooper, Peter Burney, William M. Vollmer, Mary English language, clinical and experimental work Anne McBurnie, Thorarinn Gislason, Wan C. Tan, Anamika dealing with all aspects of respiratory medicine. In addition Jithoo, Ali Kocabas, Tobias Welte and A. Sonia Buist to original material, the ERJ prints Editorials and Reviews, as well as Letters and Correspondence. 1354 Sputum colour and bacteria in chronic bronchitis exacerbations: a pooled analysis This Journal is abstracted/indexed in: Ad Referendum, Marc Miravitlles, Frank Kruesmann, Daniel Haverstock, ADONIS, Biological Abstracts/BIOSIS, Chemical Abstracts, Renee Perroncel, Shurjeel H. Choudhri and Pierre Arvis Current Contents: Life Sciences, Current Contents: Clinical Medicine, Elsevier BIOBASE/Current Awareness in 1361 Mast cells in COPD airways: relationship to bronchodilator Biological Sciences, EMBASE/Excerpta Medica, Index responsiveness and angiogenesis Medicus/MEDLINE, Medical Documentation Service, Amir Soltani, Yean Pin Ewe, Zhen Sheng Lim, Sukhwinder Research Alert, Science Citation Index, SciSearch, SIIC S. Sohal, David Reid, Steve Weston, Richard Wood-Baker Data Base and CABI Global Health. and E. Haydn Walters 1368 DNA damage as a molecular link in the pathogenesis of SUBSCRIPTIONS COPD in smokers Kazutestu Aoshiba, Fang Zhou, Takao Tsuji and Atsushi ERJ is published monthly by the European Respiratory Nagai Society (ERS). Twelve issues are published annually in two volumes of six issues each. The volumes for 2012 are 1377 Effect of fruit and vegetable intake on oxidative stress Volumes 39 and 40. and inflammation in COPD: a randomised controlled trial Francina R. Baldrick, J. Stuart Elborn, Jayne V. Woodside, Subscription rates for institutions (Volumes 39 & 40, 2012): Katherine Treacy, Judy M. Bradley, Chris C. Patterson, £673.00 online only, £794.00 print and online; US$1,278.00 Bettina C. Schock, Madeleine Ennis, Ian S. Young and online only, US$1,508.00 print and online in North America. Michelle C. McKinley Subscription rates include air ecomomy postage. Subscriptions are payable in advance. 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All orders, payments, and claims for missing issues continuous positive airway pressure therapy should be sent to Maney Publishing or to any subscription Angela L. Denotti, Keith K.H. Wong, George C. Dungan II, agent. John W. Gilholme, Nathaniel S. Marshall and Ronald R. Grunstein ONLINE ACCESS Press 1398 Effect of Mediterranean diet versus prudent diet combined All subscribers have online access to the full text of each release with physical activity on OSAS: a randomised trial issue as part of their subscription. The online version is Christopher Papandreou, Sophia E. Schiza, Izolde available to members via www.ersnet.org. Institutional Bouloukaki, Christos M. Hatzis, Anthony G. Kafatos, subscribers can access online through HighWire at Nikolaos M. Siafakas and Nikolaos E. Tzanakis www.erj.ersjournals.com Pulmonary vascular disease Members of the ERS receive the ERJ as part of their membership. 1405 Targets of anti-endothelial cell antibodies in