Supplementary Figure 3b: Genes with altered expression levels of 2-fold or greater in response to over-expression of CREB in stably-transfected myometrial cell lines: main list (genes known or thought to be linked with myometrial activity).

Gene Fold change Genbank Gene Fold change Genbank Cell adhesion Immunity proteins (complement/MHC/blood coagulation) cont’d SELE selectin E (endothelial adhesion molecule 1) 6.4  NM_000450 C4B complement component 4B 2.0  NM_000592 ICAM4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group 3.0  NM_001544 C9 complement component 9 2.6  K02766.1 C1QA complement component 1, q subcomponent, alpha polypeptide 2.6  NM_015991 ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor 2.1  AA284705 Cytokines, hormones & receptors Cell Death IL18 interleukin 18 (interferon-gamma-inducing factor) 7.2  NM_001562 TNFRSF9 tumor necrosis factor receptor superfamily, member 9 5.2  BC006196.1 IL8 interleukin 8 6.7  AF043337.1 ARTS-1 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator 3.1  BE551138 CCL23 chemokine (C-C motif) ligand 23 4.9  U58913.1 TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.9  U72763.1 PTGFR prostaglandin F receptor (FP) 3.9  NM_000959 TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally 2.6  NM_003326 LHCGR luteinizing hormone/choriogonadotropin receptor 3.4  NM_000233 activated glycoprotein 1, 34kDa) OXTR oxytocin receptor 3.4  NM_000916 TNFAIP2 tumor necrosis factor, alpha-induced protein 2 2.4  AI862445 IL-17RC interleukin 17 receptor C 3.4  BF112057 TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.1  NM_001066 DTR diphtheria toxin receptor (heparin-binding epidermal growth factor-like 3.3  M60278 growth factor) TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an 2.5  AF012536.1 CXCL11 chemokine (C-X-C motif) ligand 11 2.6  AF002985.1 intracellular domain CCL20 chemokine (C-C motif) ligand 20 2.1  NM_004591

Cell growth & maintenance ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.1  U95204.1 FGF18 fibroblast growth factor 18 5.0  AB007422.1 CCL24 chemokine (C-C motif) ligand 24 2.1  NM_002991 FGF17 fibroblast growth factor 17 4.2  NM_003867 CCL3 chemokine (C-C motif) ligand 3 2.1  NM_002983 PTN pleiotrophin (heparin binding growth factor 8, neurite growth-promoting 2.6  BC005916.1 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 2.5  NM_000609 factor 1) CCL15 chemokine (C-C motif) ligand 15 12.5  AF031587.1

IGFBP3 insulin-like growth factor binding protein 3 2.0  NM_000598.1 FGF6 fibroblast growth factor 6 5.0  NM_020996 Transport GAS1 growth arrest-specific 1 33.3  AW611727 SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 5.2  AB014602.1 SLC30A6 likely ortholog of mouse zinc transporter 6 3.9  NM_017964 Cell surface linked signal transduction ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.2  AF225981.1

ITGB8 integrin, beta 8 4.5  NM_002214 SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4 2.0  AF047338.1 RGS10 regulator of G-protein signalling 10 3.1  AI744627 ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.3  NM_000703.1 RGS20 regulator of G-protein signalling 20 2.5  AF074979.1 SLC39A2 solute carrier family 39 (zinc transporter), member 2 3.0  NM_014579 ITGB2 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated 2.4  NM_000211 antigen 1; macrophage antigen 1 (mac-1) beta subunit) G6PT glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1 3.1  AF097831 ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.4  NM_000885 ITGB4 integrin, beta 4 2.0  NM_000213 Non-classified / other LOC64182 similar to rat myomegalin (cAMP-responsive; localizes components 10.2  AB042557.1 KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2 2.5  AB044806.1 of cAMP pathway) SCN11A sodium channel, voltage-gated, type XI, alpha polypeptide 3.3  AF150882.1 AQP4 aquaporin 4 6.3  U63622.1 2+ RGS12 regulator of G-protein signalling 12 3.3  AW170602 CAPN10 calpain 10 (Ca -dependent; cytoskeletal remodeling & signal transduction) 6.1  NM_023089 RGS14 regulator of G-protein signalling 14 3.3  AF037194.1 CALML3 calmodulin-like 3 5.6  M36707.1 CBX7 ESTs, Highly similar to potassium voltage-gated channel, 3.3  AV648364 TRPC4 transient receptor potential cation channel, subfamily C, member 4 4.3  NM_016179 Isk-related subfamily, gene 4; potassium voltage-gated channel-like ADRA1A adrenergic, alpha-1A-, receptor 4.1  D32202.1 protein, Isk-related subfamily [Homo sapiens] [H.sapiens] MEF2D MADS box transcription enhancer factor 2, polypeptide D 3.8  AL530331 KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4 5.0  NM_004700 (myocyte enhancer factor 2D) (involved in muscle-specific and/or growth- factor related transcription) Developmental processes KCNK2 potassium channel, subfamily K, member 2 3.8  AF004711.1 HIST1H2BI H2B histone family, member K 3.6  NM_003525 SOX11 SRY (sex determining region Y)-box 11 2.6  AI360875 H4FN H4 histone, family 2 3.5  NM_003548 SOX4 SRY (sex determining region Y)-box 4 2.9  AI989477 LOC57086 smooth muscle cell-expressed and macrophage conditioned medium- 3.4  NM_020351 induced Intracellular signalling protein smag-64 KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta 3.8  U33428.1 H2BFB H2B histone family, member B 3.3  AL353759 member 1 KCNN2 potassium intermediate/small conductance calcium-activated channel, 2.9  NM_021614 SCN2B sodium channel, voltage-gated, type II, beta polypeptide 2.6  U87555.1 subfamily N, member 2 KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12 2.9  NM_021012 ARHGAP6 Rho GTPase activating protein 6 2.1  NM_006125 HIST1H2BL H2B histone family, member C 2.6  NM_003519 ARHGAP1 Rho GTPase activating protein 1 2.6  U62794.1 AKAP11; clone RP11-215B13 on chromosome 13 Contains the AKAP11 gene 2.5  AL136527 PRKA11; for A kinase (PRKA) anchor protein 11, part of a novel gene, AKAP220; a fumarate hydratase (FH) pseudogene, the 3' end of the DGKH Pregnancy AKAP220; gene for diacylglycerol kinase eta and a CpG Island PSG5 pregnancy specific beta-1-glycoprotein 5 3.6  NM_002781 FLJ11304; PSG3 pregnancy specific beta-1-glycoprotein 3 3.0  NM_021016 KIAA0629 PSG6 pregnancy specific beta-1-glycoprotein 6 2.7  M31125.1 ESR1 estrogen receptor 1 2.5  AF258450.1 CRHR2 corticotropin releasing hormone receptor 2 (may modulate 2.5  AF019381.1 myometrial inflammatory response) Extracellular matrix AKAP7 A kinase (PRKA) anchor protein 7 2.5  AF161075.1 MMP1 matrix metalloproteinase 1 (interstitial collagenase) 42.2  NM_002421 Putative endothelin receptor type B-like protein [Homo sapiens], 2.5  U87460.1 PCLO piccolo (presynaptic cytomatrix protein) 6.3  BC001304.1 mRNA sequence SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of 5.3  NM_014140 HIST1H2BM H2B histone family, member E 2.5  NM_003521 chromatin, CCR6 Chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; 2.4  NM_004367 subfamily a-like 1 G protein-coupled receptor 29; seven-transmembrane receptor, MMP23A matrix metalloproteinase 23A 4.7  NM_004659 lymphocyte, 22; COL13A1 collagen, type XIII, alpha 1 4.0  M33653.1 chemokine receptor-like 3 [Homo sapiens], mRNA sequence COL11A2 collagen, type XI, alpha 2 3.6  AL031228 GPRC5B G protein-coupled receptor, family C, group 5, member B 2.2  NM_016235 FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 2.7  NM_015839 DF D component of complement (adipsin) 2.2  NM_001928 SOCS1 suppressor of cytokine signaling 1 2.2  NM_003745.1 COL5A1 collagen, type V, alpha 1 2.1  AI130969 AQP8 aquaporin 8 2.1  NM_001169 COL6A2 collagen, type VI, alpha 2 2.6  AY029208.1 H2AFC H2A histone family, member C 2.1  NM_003509.1 COL16A1 collagen, type XVI, alpha 1 2.9  NM_001856 HIST1H1E H1 histone family, member 4 2.1  NM_005321 COL4A2 collagen, type IV, alpha 2 2.9  AK025912.1 CAV2 caveolin 2 (functionally regulates G protein alpha subunits) 2.1  AA150110 BGN biglycan 2.9  AA845258 ADRB2 adrenergic, beta-2-, receptor, surface 2.0  NM_000024 COL6A1 collagen, type VI, alpha 1 3.2  BE350145 MATN1 matrilin 1, cartilage matrix protein 3.3  NM_002379 CCR3 chemokine (C-C motif) receptor 3 2.0  NM_001837 COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 5.6  U02520.1 TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.0  NM_012471 COL18A1 collagen, type XVIII, alpha 1 8.3  NM_030582.1 ADRA2A adrenergic, alpha-2A-, receptor 2.1  AF284095.1 GPR86 G protein-coupled receptor 86 2.1  NM_023914 Chromatin H1FX H1 histone family, member X 2.2  NM_006026 OXT oxytocin, prepro- (neurophysin I) 2.2  NM_000915 SMARCF1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,3.6  NM_006015 subfamily f, member 1 H2AFY2 H2A histone family, member Y2 2.3  NM_018649 PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.3  L27489.1 Cytoskeletal proteins PCDHGA8 protocadherin gamma subfamily A, 8 (Ca2+ dependent cell adhesion) 2.4  AB002325.1 SVIL Supervillin (actin binding) 2.4  AW872377 LOC51036 retinoic acid receptor-beta associated open reading frame 2.4  NM_015854 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal 2.2  NM_006079 RARA retinoic acid receptor, alpha 2.5  NM_000964 domain, 2 THBS1 thrombospondin 1 (mediates cell-cell & cell-matrix interactions) 2.5  AI812030 TPM1 tropomyosin 1 (alpha) 2.0  NM_000366 CRHR1 corticotropin releasing hormone receptor 1 2.6  X72304.1 IL4R interleukin 4 receptor 2.7  NM_000418 Protein kinases IL18BP interleukin 18 binding protein 2.8  NM_005699 PRKCA protein kinase C, alpha 8.7  NM_002737 KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 2.9  U39195.1 PRKCB1 protein kinase C, beta 1 5.1  NM_002738 CALCRL calcitonin receptor-like 2.9  U17473.1 PRKCZ protein kinase C, zeta 4.5  NM_002744 CCR5 chemokine (C-C motif) receptor 5 2.9  NM_000579 CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 3.4  AF078803.1 H2AFN H2A histone family, member N 3.2  NM_003514.1 MAPK14 mitogen-activated protein kinase 14 2.3  Z25432.1 RDC1 G protein-coupled receptor 3.4  AI817041 GPR17 G protein-coupled receptor 17 3.8  Z94154.1 PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 2.8  AI814660 GPR3 G protein-coupled receptor 3 4.0  AW024085 PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.8  NM_016223 IL17 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) 4.9  NM_002190 IL4 interleukin 4 5.0  NM_000589 Immunity proteins (complement/MHC/blood coagulation) PTGDR prostaglandin D2 receptor (DP) 6.3  U31099.1 C1QB complement component 1, q subcomponent, beta polypeptide 4.9  NM_000491 GPR107 G protein-coupled receptor 107 8.3  NM_020960 F2RL2 coagulation factor II (thrombin) receptor-like 2 2.5  NM_004101 IL26 interleukin 26 8.3  NM_018402 F2 coagulation factor II (thrombin) 2.3  NM_000506

Supplementary Figure 3c: Genes with altered expression levels of 2-fold or greater in response to over-expression of CREMα in stably-transfected myometrial cell lines.

Gene Fold change Genbank Gene Fold change Genbank Cell growth & maintenance Non-classified cont’d CDC25A cell division cycle 25A 4.9  NM_001789 FBI1 HIV-1 inducer of short transcripts binding protein; 17.9  NM_015898.1 GDF2 growth differentiation factor 2 3.7  NM_016204 lymphoma related factor CDC2L2 cell division cycle 2-like 2 2.0  U04819.1 FANCF Fanconi anemia, complementation group F 7.8  NM_022725 CREM cAMP responsive element modulator 7.4  S68134.1 CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) 2.0  AF064103.1 PRO1966 [Homo sapiens], mRNA sequence 6.6  NM_018611 GAS1 growth arrest-specific 1 33.3  AW611727 CAPN10 calpain 10 6.0  NM_023083 SNRK SNF-1 related kinase 5.1  NM_017719 Ser/Thr & Tyr kinase signalling HIST1H2BI H2B histone family, member K 4.7  NM_003525 EMP1 epithelial membrane protein 1 4.7  NM_001423 STK29 serine/threonine kinase 29 3.8  AJ006701.1 GPR30 G protein-coupled receptor 30 4.3  U63917.1 PTK9L protein tyrosine kinase 9-like (A6-related protein) 2.1  NM_007284 SOCS1 suppressor of cytokine signaling 1 3.6  AB005043.1 NRP1 neuropilin 1 3.3  AF145712.1 Integrin receptor signalling SMT3H2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 3.0  AI971724 ADAM7 a disintegrin and metalloproteinase domain 7 5.6  AF215824.1 DC13 DC13 protein 2.9  NM_020188 ITGB8 integrin, beta 8 2.8  NM_002214 EVA1 epithelial V-like antigen 1 2.7  AF275945.1 NRXN3; neurexin 3 2.6  AF123462 KIAA0743 Developmental processes ZNF364 zinc finger protein 364 2.3  AL530462 D21S2056 DNA segment on chromosome 21 (unique) 2056 expressed 8.1  NM_003683 PAX5 paired box gene 5 (B-cell lineage specific activator protein) 2.2  NM_016734 sequence LOC51668 HSPCO34 protein 2.2  AV702994 GNB5 guanine nucleotide binding protein (G protein), beta 5 2.2  NM_006578 Intracellular signalling LGALS3 lectin, galactoside-binding, soluble, 3 (galectin 3) 2.2  BC001120.1 STEAP six transmembrane epithelial antigen of the prostate 3.4  AW129021 YKT6 SNARE protein Ykt6 2.1  NM_006555 KCNH6 potassium voltage-gated channel, subfamily H (eag-related), 2.3  NM_030779 OSTF1 osteoclast stimulating factor 1 2.1  NM_012383 member 6 LAT linker for activation of T cells 2.1  AF036905.1 Type II AF10 protein [Homo sapiens], mRNA sequence 2.0  AF060938.1 KCNH2 potassium voltage-gated channel, subfamily H (eag-related), 2.8  AB044806.1 ARL1 ADP-ribosylation factor-like 1 2.0  NM_001177.2 member 2 KCNA3 potassium voltage-gated channel, shaker-related subfamily, 4.0  NM_002232 CPZ carboxypeptidase Z 2.0  BC006393.1 member 3 DAB1 disabled homolog 1 (Drosophila) 2.5  NM_021080 SPAG11 sperm associated antigen 11 2.6  AF168617.1 SPHK2 sphingosine kinase 2 2.7  AF245447.1 Pregnancy C10orf1 HUG1 gene 2.8  NM_020527 PSG3 pregnancy specific beta-1-glycoprotein 3 2.5  AB019570.1 E46L; fibulin 1 3.1  Z95331 DKFZP586H22 Intracellular 19 WBSCR14 Williams Beuren syndrome chromosome region 14 3.3  NM_015977 PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 15.8  AI962377 SLIT3 slit homolog 3 (Drosophila) 3.4  NM_003062 EEA1 early endosome antigen 1, 162kD 3.9  AI916242 DACH dachshund homolog (Drosophila) 3.7  NM_004392 PCNP PEST-containing nuclear protein 2.6  BC005903.1 WBSCR5 Williams-Beuren syndrome chromosome region 5 3.8  AF257135.1 NAP1L1 nucleosome assembly protein 1-like 1 2.4  BC002387.1 KRT7 keratin 7 4.0  BC002700.1

HCN3 hyperpolarization activated cyclic nucleotide-gated 4.2  BF110802 NPAT nuclear protein, ataxia-telangiectasia locus 2.0  U58852.1 potassium channel 3 ATIP1 AT2 receptor-interacting protein 1 2.8  AL096842.1 BRDG1 BCR downstream signaling 1 5.9  NM_012108 CYP2A13 cytochrome P450, subfamily IIA (phenobarbital-inducible), 3.6  NM_000766 SERPING1 serine (or cysteine) proteinase inhibitor, clade G 6.3  NM_000062 polypeptide 13 (C1 inhibitor), member 1, (angioedema, hereditary) AVPR2 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) 6.3  NM_000054 Membrane DUX3 double homeobox, 3 7.1  NM_012148 ITM2A; E25A integral membrane protein 2A 2.5  AL021786 PACE4 paired basic amino acid cleaving system 4 7.1  D28514.1 IL26 interleukin 26 9.1  NM_018402 Apoptosis regulation KIAA0987 erythrocyte membrane protein band 4.1-like 3 11.7  NM_012307 CFLAR CASP8 and FADD-like apoptosis regulator 3.2  AF005775.1 Miscellaneous Cancer D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed 8.1  NM_003683 sequence RAB7 RAB7, member RAS oncogene family 5.6  AK024417.1 Unknown (protein for MGC:11120) [Homo sapiens], 5.1  BG334495 mRNA sequence Cell cycle regulation KIAA0450 KIAA0450 gene product 4.8  NM_014638 CDK2 cyclin-dependent kinase 2 3.2  AB012305.1 ESTs, Highly similar to uncharacterized hypothalamus protein 4.3  AF119892.1 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 12.7  D64137 HT010 [Homo sapiens] [H.sapiens] Homo sapiens mRNA; cDNA DKFZp434P2435 (from clone 4.0  AL117520.1 Enzymes DKFZp434P2435), mRNA sequence Homo sapiens mRNA; cDNA DKFZp586L1824 3.0  AL117663.1 DUSP6 dual specificity phosphatase 6 17.8  BC005047.1 (from clone DKFZp586L1824), mRNA sequence PTENP1 phosphatase and tensin homolog (mutated in multiple advanced 11.8  AF023139.1 ESTs, Moderately similar to hypothetical protein FLJ20378 2.9  AV661514 cancers 1) [Homo sapiens] [H.sapiens] , pseudogene 1 MGC2508 hypothetical protein MGC2508 2.9  AA639585 POMT2 putative protein O-mannosyltransferase 6.3  NM_013382 B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, 5.2  Y15014.1 Homo sapiens cDNA: FLJ22209 fis, clone HRC01496, 2.8  AK025862.1 polypeptide 2 mRNA sequence TOP1 topoisomerase (DNA) I 4.8  AW025108 Homo sapiens cDNA FLJ12058 fis, clone HEMBB1002092, 2.7  AK022120.1 SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit 2.2  NM_003849 mRNA sequence FLJ10661 hypothetical protein FLJ10661 2.5  NM_018172 GSTA3 glutathione S-transferase A3 2.1  NM_000847.1 Homo sapiens cDNA FLJ13754 fis, clone PLACE3000362, 2.4  AK023816.1 ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 2.3  NM_020632 mRNA sequence MGC1203 hypothetical protein MGC1203 2.3  AL049795 Complement/MHC/Blood coagulation Unnamed protein product [Homo sapiens], mRNA sequence 2.2  NM_025033 TTID titin immunoglobulin domain protein (myotilin) 2.4  NM_006790 Homo sapiens cDNA: FLJ21533 fis, clone COL06072, 2.1  BE965029 SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, 3.1  NM_004636 mRNA sequence secreted, (semaphorin) 3B KIAA1393 KIAA1393 protein 2.1  AB037814.1 CYP2E1 2.1  AV650427 Nucleic acid binding TFAM transcription factor A, mitochondrial 10.4  NM_012251 FLJ22233 hypothetical protein FLJ22233 2.3  NM_024959 CRSP8 cofactor required for Sp1 transcriptional activation, subunit 8, 8.9  BC002878.1 GRTP1 hypothetical protein FLJ22474 2.3  NM_024719 34kDa DKFZP586I111 DKFZP586I111 protein 2.4  AL050131.1 EIF3S8 eukaryotic translation initiation factor 3, subunit 8, 110kDa 2.4  AA679705 SNRPG small nuclear ribonucleoprotein polypeptide G 2.2  NM_003096 ESTs 2.5  BF229395 KIAA0367 KIAA0367 protein 2.7  AB002365.1 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix 3.6  NM_001546.1 RPS20 2.8  AL576654 protein Homo sapiens mRNA; cDNA DKFZp586M0723 2.8  AW242315 (from clone DKFZp586M0723), mRNA sequence snRNA KIAA0363 KIAA0363 protein 3.1  AB002361.1 LSM7 U6 snRNA-associated Sm-like protein LSm7 2.0  NM_016199 Homo sapiens mRNA; cDNA DKFZp547I147 5.0  AL390133.1 (from clone DKFZp547I147), mRNA sequence PRO0644 [Homo sapiens], mRNA sequence 5.0  NM_014136 Structural proteins 8.7  BE892698 SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of 5.2  NM_014140 MGC10848 hypothetical protein MGC10848 33.3  NM_030569 chromatin, subfamily a-like 1 BFSP1 beaded filament structural protein 1, filensin 4.5  NM_001195

Supplementary Figure 3d: Genes with altered expression levels of 2-fold or greater in response to

over-expression of CREMτ2α in stably-transfected myometrial cell lines.

Gene Fold change Genbank Gene Fold change Genbank Cell adhesion Complement/MHC/Blood coagulation JAM2 junctional adhesion molecule 2 6.8  NM_021219 C1QB complement component 1, q subcomponent, beta polypeptide 4.8  NM_000491 IGHM immunoglobulin heavy constant mu 3.1  X95660.1 Cell growth & maintenance F3 coagulation factor III (thromboplastin, tissue factor) 2.3  NM_001993 FGF17 fibroblast growth factor 17 7.6  NM_003867 MGC4189 complement component 1, q subcomponent binding protein 2.2  AU151801 FGF18 fibroblast growth factor 18 5.4  AB007422.1 SLC16A4 solute carrier family 16 (monocarboxylic acid transporters), member 4 4.1  NM_004696 KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long 2.5  AF262973.1 PGF placental growth factor, vascular endothelial growth factor-related protein 2.9  BC001422.1 cytoplasmic tail, 1

PEX10 peroxisome biogenesis factor 10 2.3  AB013818.1 CDC2L2 cell division cycle 2-like 2 2.3  U04819.1 Nucleic acid binding DDX7 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 7 (RNA helicase, 52kDa) 5.1  NM_004940 SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.1  NM_006516.1 EIF3S6 eukaryotic translation initiation factor 3, subunit 6 48kDa 4.2  N25429

CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 3.5  U38945.1 GAS2 growth arrest-specific 2 3.8  NM_005256 GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.9  BC001771.1 Human insulin-like growth factor 1 receptor mRNA, 3' sequence, 4.0  NM_000875.2 mRNA sequence EIF1A eukaryotic translation initiation factor 1A 2.7  BE542684 GAS1 growth arrest-specific 1 51.1  AW611727 EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.6  NM_004094 TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 2.6  NM_005648 Signal transduction E4F1 E4F transcription factor 1 2.3  NM_004424 CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 5.1  W81196 TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 2.3  NM_007108.1 GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 5.0  M81882.1 GTF3A general transcription factor IIIA 2.2  BE542815 SCN2B sodium channel, voltage-gated, type II, beta polypeptide 4.4  U87555.1 EIF3S4 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa 2.0  BC000733.1 CST1 cystatin SN 4.1  NM_001898 RGS11 regulator of G-protein signalling 11 3.3  AB016929.1 Non-classified TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 2.6  BF217301 GPR30 G protein-coupled receptor 30 10.7  U63917.1 COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 2.5  NM_003653 RAI1 retinoic acid induced 1 6.0  NM_030665 PSG1 pregnancy specific beta-1-glycoprotein 1 2.5  M34715.1 HIST1H2BI H2B histone family, member K 5.3  NM_003525 IGKC immunoglobulin kappa constant 2.3  M63438.1 HAGE DEAD-box protein 5.1  NM_018665 PVR poliovirus receptor 2.0  BE615277 S100A7 S100 calcium binding protein A7 (psoriasin 1) 4.7  NM_002963 AZGP1 alpha-2-glycoprotein 1, zinc 4.1  AC004522 ADAMTS8 a disintegrin-like and metalloprotease (reprolysin type) with 2.1  NM_007037 LAMB3 laminin, beta 3 3.9  L25541.1 thrombospondin type 1 motif, 8 COIL coilin 3.9  BG391060 KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2 2.8  AB044806.1 IL-17RC interleukin 17 receptor C 3.8  BF112057 TACR1 tachykinin receptor 1 3.8  M81797.1 PIWIL1 piwi-like 1 (Drosophila) 3.8  AW189518 KCNC2 potassium voltage-gated channel, Shaw-related subfamily, member 2 5.7  AW149844 GJB3 gap junction protein, beta 3, 31kDa (connexin 31) 3.7  AF099730 CCL15 chemokine (C-C motif) ligand 15 10.1  AF031587.1 FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 3.6  NM_005251.1

SGT small glutamine-rich tetratricopeptide repeat (TPR)-containing 3.5  NM_003021 Extracellular matrix ANXA2P2 annexin A2 pseudogene 2 3.4  M62898.1 COL13A1 collagen, type XIII, alpha 1 7.0  M59217.1 TRIM2 tripartite motif-containing 2 3.4  AA149745 LSR7 lipopolysaccharide specific response-7 protein 3.3  NM_018559 COL4A4 collagen, type IV, alpha 4 4.2  D17391.1 AND-1 AND-1 protein 3.2  AK001538.1 UP uridine phosphorylase 3.2  NM_003364 Chromatin GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.2  NM_002068 SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of 7.6  NM_014140 ALK anaplastic lymphoma kinase (Ki-1) 3.2  U66559.1 chromatin, subfamily a-like 1 PCDH9 protocadherin 9 3.2  AI524125 NAP1L1 nucleosome assembly protein 1-like 1 2.2  BC002387.1 CLDN7 claudin 7 3.1  NM_001307

ADRB2 adrenergic, beta-2-, receptor, surface 3.0  NM_000024

Cytochrome HUS1 HUS1 checkpoint homolog (S. pombe) 2.9  AI968626 CYP2C8 cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), 7.1  NM_030878 CD86 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 2.8  L25259.1 polypeptide 8 CYB5-M cytochrome b5 outer mitochondrial membrane precursor 2.4  NM_030579 G1P2 interferon, alpha-inducible protein (clone IFI-15K) 2.8  NM_005101 NJMU-R1 protein kinase Njmu-R1 2.7  NM_022344 PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 2.7  NM_002799 Cytoskeleton NYD-SP15 protein kinase NYD-SP15 2.6  NM_030911 SIP Siah-interacting protein 2.4  AF275803.1 ADK adenosine kinase 2.6  NM_001123 PIN4 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) 2.2  BE674061 DLG3 discs, large (Drosophila) homolog 3 (neuroendocrine-dlg) 2.6  AB033058.1 LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.0  BF965566 EPPB9 B9 protein 2.6  NM_015681

KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.6  BC005978.1 ALP alpha-actinin-2-associated LIM protein 3.8  AF002280.1 MGLL monoglyceride lipase 2.6  BC006230.1 HPIP hematopoietic PBX-interacting protein 6.0  BF344265 F-LAN-1 CGI-101 protein 2.6  NM_016041

EMP3 epithelial membrane protein 3 2.5  NM_001425 Golgi associated PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.5  NM_002810 GOLGIN-67 golgin-67 4.5  AF163441.1 HFL-EDDG1 erythroid differentiation and denucleation factor 1 2.4  NM_006553 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 5.4  AI799984 COQ4 CGI-92 protein 2.4  NM_016035

DBN1 drebrin 1 2.3  NM_004395

Mitochondrial PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.3  AL545523 TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 2.3  NM_006327 OSTF1 osteoclast stimulating factor 1 2.3  NM_012383

SEMA5A sema domain, seven thrombospondin repeats (type 1 and 2.3  NM_003966 Nuclear type 1-like), transmembrane domain (TM) and short cytoplasmic NVL nuclear VCP-like 4.6  NM_002533 domain, (semaphorin) 5A LOC92558 Human clone 295, 5cM region surrounding hepatocyte nuclear 3.7  AA319460 RPL29 ribosomal protein L29 2.2  AW582267 factor-1a/MODY3 mRNA, mRNA sequence BCL7C B-cell CLL/lymphoma 7C 2.2  NM_004765 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 2.5  NM_006938 FNBP1 formin binding protein 1 2.2  AU145053 BAIAP3 BAI1-associated protein 3 2.2  AL031709 NFIB nuclear factor I/B 5.9  U70862.1 ARL3 ADP-ribosylation factor-like 3 2.2  NM_004311 LSM5 U6 snRNA-associated Sm-like protein 2.2  NM_012322 Cancer CUL4A cullin 4A 2.2  NM_003589 TSSC3 tumor suppressing subtransferable candidate 3 6.6  AF001294.1 HT010 uncharacterized hypothalamus protein HT010 2.2  AV716798 ESTs, Moderately similar to RL10_HUMAN 60S Ribosomal protein L10 4.6  BG151284 CTSK cathepsin K (pycnodysostosis) 2.2  NM_000396 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.1  NM_003460 [H.sapiens] PFDN4 prefoldin 4 2.1  NM_002623 KRAS2 v-Ki-ras2 Kirsten rat 2.7  BF673699 sarcoma 2 viral oncogene homolog RPP40 ribonuclease P, 40kD subunit 2.0  NM_006638.1 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation 2.0  NM_003406 protein, zeta polypeptide MAG myelin associated glycoprotein 2.0  X98405.1 Cell cycle regulator PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.0  NM_006503 CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 5.4  AL567411

CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 3.5  U38945.1 CA12 carbonic anhydrase XII 2.0  BC000278.1 HMOX2 heme oxygenase (decycling) 2 2.3  D21243.1 PRPF31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 2.1  AI334332

DLEC1 deleted in lung and esophageal cancer 1 2.2  NM_007337 CDKL5 cyclin-dependent kinase-like 5 2.1  NM_003159 CD1D CD1D antigen, d polypeptide 2.4  NM_001766 CDK10 cyclin-dependent kinase (CDC2-like) 10 2.9  NM_003674 MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.5  BG034972

HLXB9 homeo box HB9 2.5  AI738662

Enzymes (general) MMD monocyte to macrophage differentiation-associated 2.7  NM_012329 ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 5.9  AK026461.1 LOC51279 complement C1r-like proteinase precursor, 2.9  NM_016546 PPP1R7 protein phosphatase 1, regulatory subunit 7 4.7  AI090331 ELA1 elastase 2A 2.9  NM_001971 FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) 3.5  NM_005246 MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 3.0  AL049698 SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit 2.9  NM_003849 Drosophila); translocated to, 4 GLRX glutaredoxin (thioltransferase) 2.7  NM_002064 ZNF215 zinc finger protein 215 3.2  NM_013250 SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast) 2.4  NM_005138 DACT1 heptacellular carcinoma novel gene 3 3.2  NM_016651 AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.1  NM_001628 SBLF stoned B-like factor 3.2  BG434174 DHPS deoxyhypusine synthase 2.0  NM_013407 Skin-specific protein [Homo sapiens], mRNA sequence 3.3  AF005082.1 GAGE2 G antigen 2 3.6  NM_001472 PNKP polynucleotide kinase 3'-phosphatase 2.2  AF038192.1 TOSO regulator of Fas-induced apoptosis 4.3  AF057557.1 CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1) 2.7  S73751.1 NRP2 neuropilin 2 4.5  AF022859.1 KRT7 keratin 7 4.8  AI920979 Dehydrogenases TRG@ T cell receptor gamma locus 4.8  M30894.1 NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 6.0  M33374.1 PRDM9 PR domain containing 9 5.0  NM_020227 NQO1 NAD(P)H dehydrogenase, quinone 1 4.6  NM_000903 RFXAP regulatory factor X-associated protein 5.0  NM_000538 SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 3.1  NM_004168 WSB1 SOCS box-containing WD protein SWiP-1 5.2  NM_015626.1 ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.9  NM_000667 ZNF238 zinc finger protein 238 5.3  NM_006352 NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa 2.6  NM_004553 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 5.6  AF074393.1 (NADH-coenzyme Q reductase) PKD1 polycystic kidney disease 1 (autosomal dominant) 5.7  L39891 AF15Q14 AF15q14 protein 6.3  NM_020380 MAN1C1 mannosidase, alpha, class 1C, member 1 7.1  NM_020379 Gene Fold change Genbank Gene Fold change Genbank Non-classified cont’d Miscellaneous cont’d FMOD fibromodulin 8.8  NM_002023 FLJ11159 hypothetical protein FLJ11159 2.0  NM_018343 E46L; fibulin 1 9.0  Z95331 C20orf24 chromosome 20 open reading frame 24 2.0  NM_018840 DKFZP586H22 LOC57228 hypothetical protein from clone 643 2.0  BC003379.1 19

RARRES1 retinoic acid receptor responder (tazarotene induced) 1 14.7  NM_002888 DKFZP566A15 hypothetical protein DKFZp566A1524 2.1  NM_030797

24 Miscellaneous DKFZP586I111 DKFZP586I111 protein 2.1  AL050131.1 Homo sapiens clone IMAGE:248602, mRNA sequence 49.1  AF339805.1 FKSG44 hypothetical protein FKSG44 2.1  AF334946.1 FLJ20060 hypothetical protein FLJ20060 31.0  NM_017645 ESTs 2.2  BF229395 Human 28S ribosomal RNA gene, complete cds 15.4  M11167 C6orf29 chromosome 6 open reading frame 29 2.6  NM_025257 Homo sapiens cDNA: FLJ20962 fis, clone ADSH00804, mRNA sequence 8.6  AK024615.1 KIAA0440 KIAA0440 protein 2.8  AB007900.1 ESTs, Moderately similar to hypothetical protein FLJ20378 7.2  AW576871 Homo sapiens cDNA FLJ14113 fis, clone MAMMA1001715, 3.0  AK024175.1 [Homo sapiens] [H.sapiens] mRNA sequence C1orf15 chromosome 1 open reading frame 15 6.5  AF288395.1 Homo sapiens cDNA FLJ25677 fis, clone TST04054, mRNA sequence 3.2  AI143879 Homo sapiens cDNA clone IMAGE:3943734 5', MRNA sequence 5.9  BE794962 RPS20 3.3  AL576654 ESTs, Highly similar to uncharacterized hypothalamus protein 5.6  AF119892.1 Orf1, mRNA sequence 3.3  AU134977 HT010 [Homo sapiens] [H.sapiens] Homo sapiens cDNA FLJ12683 fis, clone NT2RM4002457, mRNA 3.4  AA827892 PISD; PSSC; KIAA0542 gene product 5.3  AL096768 sequence Unnamed protein product [Homo sapiens], mRNA sequence 5.0  NM_025089 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 3.7  NM_003107.1 Homo sapiens mRNA; cDNA DKFZp564P116 (from clone 2.9  BF062299 1977059, mRNA sequence DKFZp564P116), mRNA sequence Homo sapiens mRNA; cDNA DKFZp566F1224 (from 4.2  AL050032.1 KIAA0553 KIAA0553 protein 2.6  AB011125.1 clone DKFZp566F1224), mRNA sequence KIAA1026 KIAA1026 protein 2.5  AB015329.1 ESTs 4.5  AW974666 HSPC155 hypothetical protein HSPC155 2.5  NM_016406 Homo sapiens cDNA: FLJ21524 fis, clone COL05921, mRNA sequence 5.0  AK025177.1 DKFZP434G22 hypothetical protein DKFZp434G2226 2.2  NM_031217 Homo sapiens clone 24566 mRNA sequence 5.0  AF070536.1 26 Homo sapiens cDNA FLJ11552 fis, clone HEMBA1003021, 5.2  AK021614.1 FLJ20452 hypothetical protein FLJ20452 2.2  BE313890 mRNA sequence HSPC031 hypothetical protein HSPC031 2.2  NM_016101 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 6.7  AL109674.1 46866, mRNA sequence FLJ13646 hypothetical protein FLJ13646 2.1  NM_024584 FLJ12505 hypothetical protein FLJ12505 8.0  NM_024749 LOC54499 putative membrane protein 2.1  AB020980.1 MGC12262 hypothetical protein MGC12262 8.4  BC005236.1 KIAA0117 KIAA0117 protein 2.1  AA887480 Homo sapiens mRNA; cDNA DKFZp564H1916 (from 8.8  AL110126.1 MGC3180 hypothetical protein MGC3180 2.1  NM_024041 clone DKFZp564H1916), mRNA sequence LOC222070 Homo sapiens cDNA FLJ32004 fis, clone NT2RP7009429, 2.1  AW006953 MGC10848 hypothetical protein MGC10848 34.4  NM_030569 mRNA sequence FLJ10287 hypothetical protein FLJ10287 2.1  NM_019083 Homo sapiens cDNA FLJ30436 fis, clone BRACE2009037, 2.1  AI983043 mRNA sequence

Supplementary Figure 3e: Genes with altered expression levels of 2-fold or greater in response to over-expression of CREB in stably-transfected myometrial cell lines: Supplementary list (non- classified genes/genes not yet linked with myometrial activity).

Gene Fold change Genbank Gene Fold change Genbank Cell adhesion Cancer SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.0  L13779.1 PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), 9.3  AF023139.1 pseudogene 1 KIAA0951 RAB1A, member RAS oncogene family 6.5  NM_014893 AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) 3.4  NM_003734 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 3.9  NM_005248 JAM2 junctional adhesion molecule 2 4.5  NM_021219 TSSC3 tumor suppressing subtransferable candidate 3 3.3  AF001294.1 CHL1 cell adhesion molecule with homology to L1CAM (close homolog of L1) 5.0  NM_006614 KRAS2 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog 2.6  BF673699 REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 2.5  NM_002908.1 Cell Death PVT1 Pvt1 oncogene homolog, MYC activator (mouse) 2.5  M34428.1 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase 5.5  NM_004402 ST7L suppression of tumorigenicity 7 like 2.5  NM_017744 activated DNase) FAT2 FAT tumor suppressor homolog 2 (Drosophila) 2.4  NM_001447 LRDD leucine-rich and death domain containing 5.9  AF274972.1 SSPN sarcospan (Kras oncogene-associated gene) 2.4  NM_005086 RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.4  NM_005402.1 Cell growth & maintenance RELB v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of 2.2  NM_006509 kappa light polypeptide gene enhancer in B-cells 3 (avian) GDF2 growth differentiation factor 2 4.9  NM_016204 PEX16 peroxisomal biogenesis factor 16 2.1  BC000467.1 NPR2L homologous to yeast nitrogen permease (candidate tumor suppressor) 2.0  AF040708.1 MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 2.1  NM_005360 GAS2L1 growth arrest-specific 2 like 1 2.0  NM_006478 PIM1 pim-1 oncogene 2.2  M24779.1 GDF1 growth differentiation factor 1 3.3  NM_001492 MPL myeloproliferative leukemia virus oncogene 2.5  NM_005373 P450RAI-2 cytochrome P450 retinoid metabolizing protein 5.0  NM_019885 THPO thrombopoietin (myeloproliferative leukemia virus oncogene ligand, 5.0  U59495.1 megakaryocyte growth and development factor) Cell cycle CDC25C cell division cycle 25C 5.0  AF277724.1 CCND2 cyclin D2 5.3  NM_001759.1 HMOX2 heme oxygenase (decycling) 2 4.2  NM_002134 Cell surface linked signal transduction CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 2.9  U38945.1 PTPRB protein tyrosine phosphatase, receptor type, B 27.7  NM_002837 CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) 2.6  BC000076.1 ADAM3A a disintegrin and metalloproteinase domain 3a (cyritestin 1) 16.6  X89657.1 D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence 8.1  NM_003683 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 3.6  NM_000076 SCAP2 src family associated phosphoprotein 2 6.4  AB014486.1 HTR2B 5-hydroxytryptamine (serotonin) receptor 2B 5.0  NM_000867 Protein kinases RGS7 regulator of G-protein signalling 7 3.8  AF090117.1 KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 8.8  NM_002253 GRM1 glutamate receptor, metabotropic 1 3.7  NM_000838 SNRK SNF-1 related kinase 7.3  NM_017719 WNT7A wingless-type MMTV integration site family, member 7A 3.1  D83175.1 CDK6 cyclin-dependent kinase 6 5.5  AI738463 GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.1  AF015730.1 CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 5.3  AL567411 PSG3 pregnancy specific beta-1-glycoprotein 3 3.0  NM_021016 TYROBP TYRO protein tyrosine kinase binding protein 5.1  NM_003332 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.0  AF021834.1 ESTs, Highly similar to LIM protein (similar to rat protein kinase C-binding 5.1  AF116705.1 HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 2.5  NM_000872 enigma) FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) 3.1  NM_005246 EDG4 endothelial differentiation, lysophosphatidic acid G-protein-coupled 2.4  AF011466.1 receptor, 4 Protein-serine/threonine kinase [Homo sapiens], mRNA sequence 2.2  Z25429.1 TAX1BP2 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.0  U25801.1 GK glycerol kinase 2.1  X68285.1

ADAMTS2 a disintegrin-like and metalloprotease (reprolysin type) with 2.0  NM_021599.1 ROR2 receptor tyrosine kinase-like orphan receptor 2 2.3  NM_004560 thrombospondin type 1 motif, 2 FLT3LG fms-related tyrosine kinase 3 ligand 4.5  NM_001459 TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) 2.0  M99436 CDK10 cyclin-dependent kinase (CDC2-like) 10 4.5  NM_003674 HTR3B 5-hydroxytryptamine (serotonin) receptor 3B 2.0  NM_006028 GIOT-2 GIOT-2 for gonadotropin inducible transcription repressor-2 2.0  NM_016264 Immunity proteins (complement/MHC/blood coagulation) TACR3 tachykinin receptor 3 2.0  NM_001059 IGKC immunoglobulin kappa constant 4.0  BG540628 TNIP3 TNFAIP3 interacting protein 3 2.5  NM_024873 KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic 2.9  AF276292.1 HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 2.5  NM_000524 tail, 4 HIRIP3 HIRA interacting protein 3 2.5  NM_003609 F3 coagulation factor III (thromboplastin, tissue factor) 2.7  NM_001993 GNGT1 guanine nucleotide binding protein (G protein), gamma transducing 2.5  NM_021955 IGL@ immunoglobulin lambda locus 2.5  X93006.1 activity polypeptide 1 IGHM immunoglobulin heavy constant mu 2.4  BG340670 PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide 2.5  BE501428 IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and 2.0  AV733266 (PTPRF), interacting protein (liprin), alpha 3 mu polypeptides ACHE acetylcholinesterase (YT blood group) 3.3  M55040.1 GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.3  X69936.1 SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) 2.1  NM_017893 D4S234E DNA segment on chromosome 4 (unique) 234 expressed sequence 3.3  BC001745.1 and short cytoplasmic domain, (semaphorin) 4G NFKB2 nuclear factor of kappa light polypeptide gene enhancer in 5.0  BC002844.1 SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 2.2  NM_004636.1 B-cells 2 (p49/p100) (semaphorin) 3B PTPRC protein tyrosine phosphatase, receptor type, C 5.0  AI809341 IGSF1 immunoglobulin superfamily, member 1 2.4  NM_001555 GABRP gamma-aminobutyric acid (GABA) A receptor, pi 5.0  NM_014211 CAMP cathelicidin antimicrobial peptide 2.5  U19970.1 STATH statherin 5.0  NM_003154 IgH VH immunoglobulin heavy constant mu 4.0  AB035175 PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 10.0  NM_012411 Microtubular dynamics Developmental processes MAP1A microtubule-associated protein 1A 5.3  AF095910.1 YBX2 germ cell specific Y-box binding protein 3.7  NM_015982 MAP1B microtubule-associated protein 1B 4.2  BG164365 MAP2 microtubule-associated protein 2 2.8  U89330.1 Intracellular signalling TGM4 transglutaminase 4 (prostate) 3.1  BF222018 KIF1C kinesin family member 1C 2.3  AB014606.1 PIASY protein inhibitor of activated STAT protein PIASy 3.1  NM_015897.1 Nucleic acid binding SSTR4 somatostatin receptor 4 2.1  NM_001052.1 ELF5 E74-like factor 5 (ets domain transcription factor) 6.9  AF115403.1 OPRK1 opioid receptor, kappa 1 2.6  NM_000912 EIF3S5 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa 5.8  AI001896 IF2 translation initiation factor IF2 5.3  BE138647 Pregnancy TFAM transcription factor A, mitochondrial 5.1  NM_012251 FEZL likely ortholog of mouse and zebrafish forebrain embryonic zinc 3.6  NM_018008 FOXM1 forkhead box M1 4.6  NM_021953 finger-like TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors 3.8  X52078.1 PSG9 pregnancy specific beta-1-glycoprotein 9 2.4  NM_002784 E12/E47) RBM5 RNA binding motif protein 5 3.8  AF107493.1 ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 6.7  NM_004432 NFYA nuclear transcription factor Y, alpha 3.6  AL031778 (Hu antigen B) LOC94431 similar to RNA polymerase I transcription factor RRN3 3.2  BC006441.1 MYH3 myosin, heavy polypeptide 3, skeletal muscle, embryonic 14.3  NM_002470 LW-1 LW-1 3.0  NM_016153 POU4F1 POU domain, class 4, transcription factor 1 2.9  L20433.1 Chromatin CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa 2.9  BC005250.1 HMGN1 high-mobility group nucleosome binding domain 1 2.9  NM_004965 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 2.7  NM_006938 ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.5  AF017307.1 Cytoskeletal proteins HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 2.3  NM_021644 BPAG1 bullous pemphigoid antigen 1, 230/240kDa 3.4  BG253119 EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.3  NM_004094 NPIP nuclear pore complex interacting protein 3.1  AC002544 PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.2  AL545523 CNTN5 contactin 5 2.8  NM_014361 CHD3 chromodomain helicase DNA binding protein 3 2.2  NM_001272 UBCE7IP5 likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting 2.6  AL121891 CHD5 chromodomain helicase DNA binding protein 5 2.0  AL035406 protein 5 GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.0  AI569458 ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.2  NM_005731

KCNIP2 Kv channel interacting protein 2 2.1  NM_014591 GATA1 GATA binding protein 1 (globin transcription factor 1) 2.0  M30601.1

NKX6-1 NK6 transcription factor related, locus 1 (Drosophila) 2.0  NM_006168 PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.0  AI692180 CDX4 caudal type homeo box transcription factor 4 2.1  NM_005193 BCoR BCL-6 interacting corepressor 2.1  NM_017745 Similar to RNA binding motif protein 4 [Homo sapiens], mRNA sequence 2.4  BE222257 CYFIP2 cytoplasmic FMR1 interacting protein 2 2.2  AL161999.1 HNRNPG-T testes-specific heterogenous nuclear ribonucleoprotein G-T 2.4  NM_014469 MYO1F myosin IF 2.3  BF740152 ZF HCF-binding transcription factor Zhangfei 2.6  AI762013 HRK harakiri, BCL2 interacting protein (contains only BH3 domain) 2.4  U76376.1 POU3F4 POU domain, class 3, transcription factor 4 2.6  NM_000307 MYO7A myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) 2.6  U55209.1 NFX1 nuclear transcription factor, X-box binding 1 2.6  AF332009.1 CASKIN2 cask-interacting protein 2 2.9  AK025262.1 NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 3.2  NM_004387 TRIP TRAF interacting protein 3.1  NM_005879 CUGBP2 CUG triplet repeat, RNA binding protein 2 4.5  U69546.1 RIPX rap2 interacting protein x 3.2  AA861784 ACTN2 actinin, alpha 2 4.2  NM_001103.1 Cytokines, hormones & receptors CNTNAP2 contactin associated protein-like 2 4.8  NM_014141.1 NPY2R neuropeptide Y receptor Y2 11.1  U32500.1 TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 6.7  AF082559.1 PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 7.0  NM_002573 PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 7.1  AI962377 29kDa HPIP hematopoietic PBX-interacting protein 10.0  BF344265 ELTD1 EGF-TM7-latrophilin-related protein 3.3  NM_022159 CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte- 3.2  BC002635.1 Protein modification macrophage) PCSK2 proprotein convertase subtilisin/kexin type 2 (protein activation) 8.5  NM_002594 TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V) 2.6  NM_030984 FKBP11 FK506 binding protein 11, 19 kDa 5.2  NM_016594 GH1 growth hormone 1 2.1  AF185611.1 LIPA lipase A, lysosomal acid, cholesterol esterase (Wolman disease) 2.1  NM_000235 SHBG sex hormone-binding globulin 2.1  AI056852 MSH6 mutS homolog 6 (E. coli) 2.1  D89646.1 LAPTM5 Lysosomal-associated multispanning membrane protein-5 3.1  AI589086 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 3.8  AI799984 TSHB thyroid stimulating hormone, beta 2.0  NM_000549.1 CEGF3 CUB and EGF containing protein 3 2.5  BF511678 Apoptosis EGFL3 EGF-like-domain, multiple 3 2.9  AL134303 GHRHR growth hormone releasing hormone receptor 2.9  NM_000823 CFLAR CASP8 and FADD-like apoptosis regulator 3.3  U97075.1 BMPR1B bone morphogenetic protein receptor, type IB 6.7  D89675.1 CASP7 caspase 7, apoptosis-related cysteine protease 2.1  NM_001227 PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 8.3  R64130

CASP10 caspase 10, apoptosis-related cysteine protease 5.0  NM_001230 Transport SKD3 suppressor of potassium transport defect 3 11.9  AI655698 TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 5.6  NM_018833 Gene Fold change Genbank Gene Fold change Genbank Transport cont’d Non-classified cont’d SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 5.1  NM_017585 TAS2R13 taste receptor, type 2, member 13 3.0  NM_023920 SLC21A6 solute carrier family 21 (organic anion transporter), member 6 4.5  AB026257.1 NRG1 neuregulin 1 3.0  L12260.1 UGTREL7 UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter 4.3  AB044343.1 DACH dachshund homolog (Drosophila) 3.0  AW772082 SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 2.8  AF142501.1 SGT small glutamine-rich tetratricopeptide repeat (TPR)-containing 3.0  NM_003021 SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), 2.8  NM_003046 RPS14 ribosomal protein S14 2.9  AF116710.1 member 2 KLF12 Kruppel-like factor 12 (Transcription factor) 2.9  NM_007249 SLC16A4 solute carrier family 16 (monocarboxylic acid transporters), member 4 2.6  NM_004696 DVS27 DVS27-related protein 2.8  AB024518.1 SLC21A15 organic anion transporter polypeptide-related protein 4 2.5  NM_030958 XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.8  NM_003399 SLC21A9 solute carrier family 21 (organic anion transporter), member 9 2.5  AB026256.1 OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 2.8  NM_016816 SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 2.0  U16120.1 TBR1 T-box, brain, 1 2.8  NM_006593

WHSC1 Wolf-Hirschhorn syndrome candidate 1 2.8  AF083389.1 SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.0  AF210455.1 PCNT2 pericentrin 2 (kendrin) (cytoskeleton structure & organization) 2.8  NM_006031 SLC23A1 solute carrier family 23 (nucleobase transporters), member 1 2.1  AL389886 KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention 2.7  NM_006855 SLC19A1 solute carrier family 19 (folate transporter), member 1 2.5  AF004354.1 receptor 3 SLC16A5 solute carrier family 16 (monocarboxylic acid transporters), member 5 3.2  NM_004695 UNG2 uracil-DNA glycosylase 2 2.7  BC004877.1 ATP8A1 ATPase, aminophospholipid transporter (APLT), Class I, type 8A, 3.7  AB013452.1 TIM50L homolog of yeast Tim50 2.7  BE378994 member 1 CA1 carbonic anhydrase I 2.6  NM_001738 FLG filaggrin 2.6  AL356504 Non-classified / other MLANA melan-A 2.6  NM_005511 RAG2 recombination activating gene 2 50.2  AW058148 PSPN persephin 2.6  NM_004158 GREB1 GREB1 protein; estrogen responsive 25.3  NM_014668 RPL5 ribosomal protein L5 2.6  U66589.1 Human 18s ribosomal RNA 18.7  M10098 CLK2 CDC-like kinase 2 ( involved in control of splicing) 2.6  NM_003993 FBXO24 F-box only protein 24 (ubiquitination) 13.3  NM_012172 PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.6  NM_002818 TA-LRRP T-cell activation leucine repeat-rich protein 12.7  D86984.1 KIR-023GB NK-receptor 2.6  AF022048.1 DPP4 dipeptidylpeptidase IV (CD26, adenosine deaminase complexing 10.3  M80536.1 TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum) 2.6  BC005374.1 protein 2) (collagen degradation) APM2 adipose specific 2 10.2  NM_006829 PRG1 proteoglycan 1, secretory granule 2.6  J03223.1 BRCA1 breast cancer 1, early onset (poss. transcriptional regulator; growth inhibitor)9.2  NM_007295 SYN3 synapsin III 2.5  NM_003490 STXBP6 syntaxin binding protein 6 (amisyn) 8.9  NM_014178 RHCE Rhesus blood group, CcEe antigens 2.5  N53959 MGC4809 serologically defined breast cancer antigen NY-BR-20 8.2  AW025529 FOXD2 forkhead box D2 2.5  NM_004474 SFRS6 splicing factor, arginine/serine-rich 6 8.2  NM_006275 SMT3H2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 2.5  AI971724 P70 ribosomal S6 kinase alpha-II, mRNA sequence 7.8  M60725.1 UNC5C unc-5 homolog B (C. elegans) 2.5  NM_003728 RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) 7.7  AI567462 TRY6 trypsinogen C 2.4  U66061 (transcription factor) KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.4  U96845.1 OR2J2 olfactory receptor, family 2, subfamily J, member 2 7.5  NM_030905 ICA1 islet cell autoantigen 1, 69kDa 2.4  NM_004968 APOF apolipoprotein F 7.4  NM_001638 Similar to uterine protein [Homo sapiens], mRNA sequence 2.4  BC002640.1 ANXA10 annexin A10 7.3  AF196478.1 ALS2CR3 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 2.4  AV705253 CDA cytidine deaminase 7.0  NM_001785 MRF-1 modulator recognition factor I (ATP-responsive inflammatory protein) 2.4  M62324.1 KLRF1 killer cell lectin-like receptor subfamily F, member 1 6.8  NM_016523 Similar to splicing factor, arginine/serine-rich 2 (SC-35) [Homo sapiens], 2.4  BC006181.1 SCEL sciellin 6.5  NM_003843 mRNA sequence ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 6.0  NM_001973 FSHPRH1 FSH primary response (LRPR1 homolog, rat) 1 2.4  NM_006733 (MAPK 1 & 8 substrate; regulates c-fos) UREB1 upstream regulatory element binding protein 1 2.4  AU140931 NRXN3 neurexin 3 5.8  NM_004796 MBD2 methyl-CpG binding domain protein 2 (transcriptional repressor) 2.4  AI827820 HOXA1 homeo box A1 5.8  S79910.1 MICA MHC class I polypeptide-related sequence A (stress/immune response) 2.4  NM_000247 RPL39L ribosomal protein L39-like 5.8  L05096.1 RPL29 ribosomal protein L29 2.4  AW582267 FANCF Fanconi anemia, complementation group F 5.8  NM_022725 APOA2 apolipoprotein A-II 2.4  NM_001643 HOXA1 homeo box A1 5.8  S79910.1 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 2.4  AU156551 Human 28S ribosomal RNA gene 5.6  M11167 (cell cycle control) AP1M2 adaptor-related protein complex 1, mu 2 subunit 5.6  NM_005498 SERPINF2 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, 2.4  NM_000934 pigment epithelium derived factor), member 2 MAGEA5 melanoma antigen, family A, 5 5.4  AI200443 NQO1 NAD(P)H dehydrogenase, quinone 1 2.4  NM_000903 HRASLS2 HRAS-like suppressor 2 5.3  NM_017878 ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.4  NM_000667 T1A-2 lung type-I cell membrane-associated glycoprotein 5.3  NM_013317 SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.4  NM_004168 ZNF258 zinc finger protein 258 5.3  NM_007167 PP35 protein similar to E.coli yhdg and R. capsulatus nifR3 2.4  NM_007016 PLAT plasminogen activator, tissue 5.3  NM_000930 RPS21 ribosomal protein S21 2.3  AW024383 COIL Coilin (affects snRNP function in splicing) 5.1  BG391060 VSX1 visual system homeobox 1 homolog, CHX10-like (zebrafish) 2.3  NM_014588 SURF2 surfeit 2 5.1  NM_017503 MTAP methylthioadenosine phosphorylase 2.3  AF109294.1 RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 5.0  D14134.1 ANXA2P2 annexin A2 pseudogene 2 2.3  M62898.1 RHEB2 Ras homolog enriched in brain 2 5.0  D78132.1 ZNF202 zinc finger protein 202 2.3  N91520 MMRN multimerin 5.0  NM_007351 HUS1 HUS1 checkpoint homolog (S. pombe) 2.3  AI968626 PLAG1 pleiomorphic adenoma gene 1 4.9  NM_002655 CSPG4 chondroitin sulfate proteoglycan 4 (melanoma-associated) 2.3  BE857703 POMT2 putative protein O-mannosyltransferase 4.9  NM_013382 S100A7 S100 calcium binding protein A7 (psoriasin 1) 2.3  NM_002963 B1 PTH-responsive osteosarcoma B1 protein 4.7  U85995 ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.3  NM_003742 FCGR2A Fc fragment of IgG, low affinity IIa, receptor for (CD32) 4.7  NM_021642 RNF6 ring finger protein (C3H2C3 type) 6 2.3  AF293342.1 KA6 induced upon T-cell activation 4.7  BF508948 AND-1 AND-1 protein 2.3  NM_007086 MSLN mesothelin 4.6  NM_005823 SH3BP1 SH3-domain binding protein 1 2.3  NM_018957.1 LSR7 lipopolysaccharide specific response-7 protein 4.6  NM_018559 TRPC4 transient receptor potential cation channel, subfamily C, 2.3  NM_016179 Siglec8 sialic acid binding Ig-like lectin 8 4.6  AF287892 member 4 (activated by Ca2+ depletion and/or G protein coupled receptors) ZNF334 zinc finger protein 334 4.5  NM_018102 TRA1 tumor rejection antigen (gp96) 1 (Ca2+ binding chaperone) 2.3  NM_003299 PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 4.5  AB044555.1 DDX26 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (involved in 2.3  NM_012141 LOC148229 similar to Glt-P1 4.5  AC004755 RNA translation & splicing, & cell growth & division) HRH4 histamine receptor H4 (may be involved in eliciting uterine relaxation) 2.3  AF312230.1 PNLIP pancreatic lipase 4.4  NM_000936 PCDHA10 protocadherin alpha 10 4.2  AF152475.1 SIM2 single-minded homolog 2 (Drosophila) (transcription factor) 2.3  NM_009586 JTV1 heme-regulated initiation factor 2-alpha kinase 4.2  AW007368 SEC23B Sec23 homolog B (S. cerevisiae) (actin binding; involved in mediation 2.3  BC005032.1 of protein transport) SFTP3 surfactant, pulmonary-associated protein B 4.2  J02761 PPP1R7 protein phosphatase 1, regulatory subunit 7 2.3  AI090331 GLE1L GLE1 RNA export mediator-like (yeast) 4.1  NM_001499 GLRX glutaredoxin (thioltransferase) 2.3  NM_002064 CDH22 cadherin-like 22 4.1  AF035300.1 SPAG6 sperm associated antigen 6 2.2  AI651156 AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 4.1  AB030653.1 TBX1 T-box 1 2.2  NM_005992 MGC1314 Human DNA sequence from clone RP1-20N2 on chromosome 4.3  AL031320 RPS26 ribosomal protein S26 2.2  NM_001029 6q24 Contains the gene for a novel protein similar to yeast and bacterial cytosine deaminase, a novel protein similar to tubulin KIAA1449 WD repeat endosomal protein 2.2  AI806628 beta polypeptide 4 member Q (TUBB4Q) (probably a pseudogene), RSHL1 radial spokehead-like 1 2.2  NM_030785 the PEX3 gene for peroxisomal biogenesis factor 3 (peroxin 3), a IGVH1 Homo sapiens partial IGVH1 gene for immunoglobulin heavy chain V region 2.2  AJ275397 VDAC1 (voltage-dependent anion channel 1 (Plasmalemmal F-LAN-1 CGI-101 protein 2.2  NM_016041 porin)) pseudogene, the gene for a novel protein similar to tissue SGP28 specific granule protein (28 kDa) 2.2  NM_006061 fucosidase alpha-L-1, a novel gene and two CpG islands, complete sequence cig5 vipirin 2.2  AI337069 MTP microsomal triglyceride transfer protein (large polypeptide, 88kDa) 4.1  AI623321 H.sapiens clathrin light chain a gene, mRNA sequence 2.2  X81636.1 ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) 4.1  NM_022436 SPTB spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) 2.2  NM_000347 GIF gastric intrinsic factor (vitamin B synthesis) 4.0  NM_005142 SPRR2C small proline-rich protein 2C 2.2  NM_006518 EVA1 epithelial V-like antigen 1 4.0  AF275945.1 TMEM5 transmembrane protein 5 2.2  BF224146 HBA1 hemoglobin, alpha 1 4.0  NM_000558 ARL1 ADP-ribosylation factor-like 1 2.2  NM_001177 EMP1 epithelial membrane protein 1 3.9  NM_001423 BAZ1B bromodomain adjacent to zinc finger domain, 1B (transcriptional regulator) 2.2  AI826454 HEMK HEMK homolog 7kb 3.8  NM_016173 YKT6 SNARE protein Ykt6 2.2  NM_006555 HSAJ1454 testican 3 3.7  BC000460.1 TDG thymine-DNA glycosylase 2.2  BF674842 PLAC3 placenta-specific 3 3.7  BF435151 NRXN2 neurexin 2 2.2  AA608820 LAMB3 laminin, beta 3 3.6  L25541.1 HCLS1 hematopoietic cell-specific Lyn substrate 1 (transcription factor) 2.2  NM_005335 CHEK1 CHK1 checkpoint homolog (S. pombe) 3.6  NM_001274 ARVCF armadillo repeat gene deletes in velocardiofacial syndrome 2.2  BG149428 NPR1 natriuretic peptide receptor A/guanylate cyclase A 3.6  NM_000906 (cell adhesion/cytoskeleton) (atrionatriuretic peptide receptor A) INE2 inactivation escape 2 2.1  AW003516 CNGB1 cyclic nucleotide gated channel beta 1 3.6  U58837.1 PROSC proline synthetase co-transcribed homolog (bacterial) 2.1  NM_007198.1 MBD4 methyl-CpG binding domain protein 4 3.6  AI913365 MGEA6 meningioma expressed antigen 6 (coiled-coil proline-rich) 2.1  U73682.1 PNMA3 paraneoplastic antigen MA3 3.5  NM_013364 LOC51145 erythrocyte transmembrane protein 2.1  NM_016158 Human 28S ribosomal RNA gene, complete cds 3.5  M11167 HFL-EDDG1 erythroid differentiation and denucleation factor 1 2.1  NM_006553 HSPC048 HSPC048 protein (expressed in muscle) 3.5  NM_014148 LY96 MD-2 protein 2.1  NM_015364 LIMK1 LIM domain kinase 1 3.5  NM_002314 PQBP1 polyglutamine binding protein 1 (transcriptional regulator) 2.1  AB041834.1 ELOVL2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, 3.5  NM_017770 CD59 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 2.1  NM_000611 yeast)-like 2 16.3A5, TAPBP-R TAP binding protein related 3.4  NM_018009 EJ16, EJ30, EL32 and G344) U5-100K prp28, U5 snRNP 100 kd protein 3.4  NM_004818 TC10 ras-like protein TC10 2.1  NM_012249.1 DTNA dystrobrevin, alpha 3.4  U46746.1 CLDN3 claudin 3 2.1  BE791251 ALOX5 arachidonate 5-lipoxygenase 3.4  NM_000698 CLIC4 chloride intracellular channel 4 2.1  AI638420 DKC1 dyskeratosis congenita 1, dyskerin 3.4  AJ010395 RIL LIM domain protein 2.1  AF153882.1 SPRY4 Homo sapiens sprouty homolog 4 (Drosophila) (SPRY4), mRNA 3.4  NM_030964 SHARP SMART/HDAC1 associated repressor protein 2.1  AL524033 (MAPK inhibitor) TMEM4 transmembrane protein 4 2.1  BC001027.1 CD86 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 3.3  L25259.1 ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 2.1  NM_000443 DLEU2 deleted in lymphocytic leukemia, 2 3.2  AF264787.1 HES2 hairy and enhancer of split (Drosophila) homolog 2 2.1  NM_019089.1 ALK anaplastic lymphoma kinase (Ki-1) 3.2  U66559.1 (transcriptional regulator) PHLDA1 pleckstrin homology-like domain, family A, member 1 3.2  AA576961 LAMB1 laminin, beta 1 2.1  NM_002291 SYCP1 synaptonemal complex protein 1 3.2  X95654.1 CARD9 caspase recruitment domain family, member 9 (apoptosis regulator) 2.1  NM_022352 ZNF10 zinc finger protein 10 (KOX 1) 3.2  X52332.1 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), 2.1  NM_003966 transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) SLC35E3 bladder cancer overexpressed protein 3.1  NM_018656 5A (cell adhesion & cell-cell signaling) HBS1L HBS1-like (S. cerevisiae) 3.1  AK024258.1 SH3BGR SH3 domain binding glutamic acid-rich protein 2.1  NM_007341 CLCA2 chloride channel, calcium activated, family member 2 3.1  AF043977.1 PFDN4 prefoldin 4 (tubulin-specific chaperone) 2.1  AI718295 GJB3 gap junction protein, beta 3, 31kDa (connexin 31) 3.1  AF099730 CGI-26 CGI-26 protein 2.1  NM_015954 BIKE BMP-2 inducible kinase 3.0  AI735391 EXO70 likely ortholog of mouse exocyst component protein 70 kDa homolog 2.1  AK023832.1 HRB2 HIV-1 rev binding protein 2 3.0  AI912583 (S. cerevisiae) Exo70: exocyst component protein 70 kDa homolog (S. cerevisiae) Gene Fold change Genbank Gene Fold change Genbank Non-classified cont’d Non-classified cont’d SSB Sjogren syndrome antigen B (autoantigen La) (probable 2.1  BG532929 RYR1 ryanodine receptor 1 (skeletal) (muscle contraction) 3.3  NM_000540 transcription termination factor) ZNF75 zinc finger protein 75 (D8C6) 3.3  AA209420 IBTK inhibitor of Bruton's tyrsoine kinase (may affect PKC activity) 2.1  AB037838.1 ANGPTL2 angiopoietin-like 2 3.3  NM_012098 TM4SF5 transmembrane 4 superfamily member 5 2.0  NM_003963 clathrin light chain b 3.4  X81637.1 HT010 uncharacterized hypothalamus protein HT010 2.0  AV716798 CRYGA crystallin, gamma A 3.4  NM_014617 SPANXA1 sperm protein associated with the nucleus, X chromosome, family 2.0  NM_013453 LENEP lens epithelial protein 3.4  NM_018655 member A1 BTF3 butyrophilin, subfamily 3, member A3 (transcriptional regulator) 2.0  U90548 HPCA hippocalcin 3.6  BC001777.1 CLCN2 chloride channel 2 2.0  NM_004366.2 SORBS1 sorbin and SH3 domain containing 1 (actin binding; cell matrix adhesion) 3.6  NM_015385 NEK1 NIMA (never in mitosis gene a)-related kinase 1 (cAMP dependent) 2.0  AL050385.1 HRH2 histamine receptor H2 3.6  NM_022304 DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.0  NM_014395 PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 3.7  AU144309 KOC1 IGF-II mRNA-binding protein 3 2.0  NM_006547 NACA nascent-polypeptide-associated complex alpha polypeptide 3.7  AI992187 CNK1 connector enhancer of KSR-like (Drosophila kinase suppressor 3.7  NM_006314 of ras) (intracellular signaling; regulates raf in MAPK pathway) EMCN endomucin 2.0  NM_016242 ITIH1 inter-alpha (globulin) inhibitor, H1 polypeptide 3.8  AF116713.1 TCL1 T-cell leukemia/lymphoma 1A 2.0  X82240 STOM Stomatin (regulates cation conductance) 3.8  AF130103.1 CAT56 CAT56 protein 2.0  NM_025263 DUSP4 dual specificity phosphatase 4 4.1  NM_001394 XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.0  AK022829.1 GAA glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) 4.1  NM_000152 ZNF318 endocrine regulator 2.0  NM_014345 UMOD uromodulin (uromucoid, Tamm-Horsfall glycoprotein) 4.2  NM_003361 PCSK5 proprotein convertase subtilisin/kexin type 5 2.0  NM_006200 CYP1A2 cytochrome P450, subfamily I (aromatic compound-inducible), 4.2  AF182274.1 Soluble interleukin-6 receptor; sIL-6R [Homo sapiens], mRNA sequence 2.0  S72848.1 polypeptide 2 GMEB1 glucocorticoid modulatory element binding protein 1 2.0  NM_006582 NPHP1 nephronophthisis 1 (juvenile) 4.2  NM_000272 (transcriptional co-activator; binds CBP) GSCL goosecoid-like 4.2  NM_005315 LRP16 LRP16 protein (up-regulated through estrogen receptor alpha) 2.0  NM_014067 BRDG1 BCR downstream signaling 1 4.2  NM_012108 ALOXE3 arachidonate lipoxygenase 3 2.0  AW003512 PLG plasminogen 4.2  M74220.1 SPTBN1 Beta II spectrin (Ca2+ dependent actin-binding cytoskeletal component) 2.0  BF434424 CD6 CD6 antigen 4.2  U66145.1 APOB48R apolipoprotein B48 receptor 2.0  NM_018690 CLDN11 claudin 11 (oligodendrocyte transmembrane protein) 4.2  AF068863.1 HBG1 hemoglobin, gamma A 2.0  NM_000559 FMO1 flavin containing monooxygenase 1 4.3  NM_002021 UTY ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome 2.1  NM_007125 FOXO1A forkhead box O1A (rhabdomyosarcoma) (transcriptional regulation) 4.3  AW117498 GAGE6 G antigen 6 2.1  NM_001476 IRS3L insulin receptor substrate 3-like 4.3  H07885 MAN1B1 mannosidase, alpha, class 1B, member 1 2.1  NM_016219 MPPE1 metallo phosphoesterase 4.4  AI082827 POP2 popeye protein 2 (upregulated in mouse pregnant myometrium) 2.1  NM_022135 MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1, 4.4  NM_002409 GAS6 nucleolar autoantigen (55kD) similar to rat synaptonemal complex protein 2.1  NM_000820 4-N-acetylglucosaminyltransferase TRA@ T cell receptor alpha locus 2.1  AE000659 LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 4.5  AI123251 CLSTN1 calsyntenin 1 (Ca2+ binding cell adhesion molecule) 2.1  NM_014944 76kDa) PALM paralemmin 4.8  NM_002579 LDLR low density lipoprotein receptor (familial hypercholesterolemia) 2.1  NM_000527 KLRB1 killer cell lectin-like receptor subfamily B, member 1 4.8  NM_002258.1 HEXA hexosaminidase A (alpha polypeptide) 2.2  AL523158 EZH1 enhancer of zeste homolog 1 (Drosophila) (transcriptional & 4.8  AB002386.1 ODF1 outer dense fiber of sperm tails 1 2.2  NM_024410.1 chromatin regulator) CLDN16 claudin 16 2.2  NM_006580 ACOX1 acyl-Coenzyme A oxidase 1, palmitoyl 4.8  S69189.1 HR hairless 2.2  NM_018411 EPB41L3 erythrocyte membrane protein band 4.1-like 3 5.0  BC006141.1 PTTG2 pituitary tumor-transforming 2 2.2  NM_006607.1 ANKRD3 ankyrin repeat domain 3 (Tyr & Ser/Thr kinase) 5.0  NM_020639 CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 2.2  BG327863 6H9A pre-T/NK cell associated protein 5.3  NM_004908 SPBPBP DNA-binding protein amplifying expression of surfactant protein B 2.2  NM_006692 ZNF42 zinc finger protein 42 (myeloid-specific retinoic acid- responsive) 5.3  AI762174 Homo sapiens A4 differentiation-dependent protein (A4), triple 2.2  U93305 PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce 5.5  NM_002600 LIM domain protein (LMO6), and synaptophysin (SYP) genes, homolog, Drosophila) complete cds; and calcium channel alpha-1 subunit (CACNA1F) gene SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 5.6  NM_003357 GIPC2 PDZ domain protein GIPC2 (modulates growth factor signaling 2.2  NM_017655 DBP D site of albumin promoter (albumin D-box) binding protein 5.6  D28468.1 & cell adhesion) MME membrane metallo-endopeptidase 2.2  AI433463 EYA2 eyes absent homolog 2 (Drosophila) 5.6  U71207.1 (neutral endopeptidase, enkephalinase, CALLA, CD10) SIRPB1 signal-regulatory protein beta 1 (negative regulator of receptor 5.6  NM_006065 SSX3 synovial sarcoma, X breakpoint 3 (transcriptional modulator) 2.2  NM_021014 tyrosine kinase-coupled signaling processes) TUBD1 likely ortholog of mouse tubulin, delta 1 2.2  NM_016261 TRG@ T cell receptor gamma locus 5.6  M30894.1 Glycogenin-2 gamma [Homo sapiens], mRNA sequence 2.3  U94364.1 ORM1 orosomucoid 1 (increased in inflammatory response) 5.6  NM_000607 FLJ20499 testis specific ankyrin-like protein 1 2.3  AL136618.1 CA2 carbonic anhydrase II 5.9  M36532.1 TPD52 tumor protein D52 2.3  BE974098 FMOD Fibromodulin (extracellular matrix; TGFbeta receptor complex assembly) 5.9  NM_002023 RREB1 ras responsive element binding protein 1 (may be involved in 2.3  AF072826.1 PYY peptide YY 6.3  NM_004160 ras/raf mediated cell differentiation) GPC5 glypican 5 6.7  NM_004466 ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.3  NM_020349 EPB41L4A erythrocyte membrane protein band 4.1 like 4A 6.7  NM_022140 CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 2.3  BE676642 MAG malignancy-associated protein 6.7  AF041410.1 BDG-29 BDG-29 proten 2.3  AB011151.1 DUX1 double homeobox, 1 7.1  NM_012146 BRAP BRCA1 associated protein (nuclear targeting) 2.3  AL042733 FOXO3A forkhead box O3A 7.7  AF041336.1 RYR2 ryanodine receptor 2 (cardiac) (involved in myometrial contraction) 2.3  NM_001035 CD1D CD1D antigen, d polypeptide 7.7  NM_001766 NTN2L netrin 2-like (chicken) (extracellular matrix) 2.3  NM_006181 PACE4 paired basic amino acid cleaving system 4 (Ca2+ dependent 7.7  D28514.1 OSR2 odd-skipped-related 2A protein (electron transporter) 2.3  AI811298 protein activation) PHF2 PHD finger protein 2 (transcriptional regulation) 2.3  AB014562.1 CYP2C8 cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), 7.7  NM_000770.2 polypeptide 8 OR1F2 olfactory receptor, family 1, subfamily F, member 2 2.4  AJ003145.1 MPZ myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) 8.3  D10537.1 WBSCR5 Williams-Beuren syndrome chromosome region 5 2.4  AF257135.1 RAI2 retinoic acid induced 2 8.3  NM_021785 PCDH16 protocadherin 16 dachsous-like (Drosophila) (Ca2+ dependent cell adhesion) 2.4  BF222893 E46L; fibulin 1 9.1  Z95331 SPHK2 sphingosine kinase 2 2.4  AF245447.1 DKFZP586H22 PRX periaxin 2.4  AB046840.1 19 A2M alpha-2-macroglobulin 2.4  NM_000014 CLMN calmin (calponin-like, transmembrane) 9.1  NM_024734 WIT-1 Wilms tumor associated protein 2.4  NM_015855 NLGN neuroligin 11.1  AI338338 AEBP1 AE binding protein 1 (transcriptional regulation; muscle development) 2.5  NM_001129 MAN1A2 mannosidase, alpha, class 1A, member 2 12.5  AK001970.1 2+ CRYM crystallin, mu 2.5  NM_001888 PLXNB1 plexin B1 (Ca dependent cell adhesion molecule) 12.5  AV693216 X102 Small evolutionarily conserved RNA, resembling C/D box small nucleolar 2.5  NM_030879 PLA2R1 Phospholipase A2 receptor 1, 180 kDa 12.9  NM_007366 DDX4 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 2.5  AY004154.1 PEX5R Pex5p-related protein 2.6  NM_016559 Supplementary: unnamed, hypothetical genes, ESTs, ORFs etc. UNC84A unc-84 homolog A (C. elegans) 2.6  NM_025154 Homo sapiens clone IMAGE:248602, mRNA sequence 66.2  AF339805.1 IDS iduronate 2-sulfatase (Hunter syndrome) 2.6  AI819115 FLJ20060 hypothetical protein FLJ20060 39.7  NM_017645 KRTAP9-9 keratin associated protein 9-9 2.6  NM_030975 MGC3731 hypothetical protein MGC3731 11.1  NM_024313 CD84 CD84 antigen (leukocyte antigen) 2.6  U96627.1 PRO2796 [Homo sapiens], mRNA sequence 10.4  NM_018633 ZNF257 zinc finger protein 257 2.6  AF070651.1 FLJ21159 hypothetical protein FLJ21159 10.0  NM_024826 EPOR erythropoietin receptor 2.6  H16758 FLJ23516 hypothetical protein FLJ23516 8.8  NM_024539 PSAP prosaposin (variant Gaucher disease and variant 2.6  NM_002778 ESTs, Moderately similar to hypothetical protein FLJ20378 [H.sapiens] 8.2  AW576871 metachromatic leukodystrophy) Homo sapiens mRNA; cDNA DKFZp566C0224 (from 7.6  AL050026.1 ANGPT2 angiopoietin 2 2.6  AF187858.1 clone DKFZp566C0224), LMOD1 leiomodin 1 (smooth muscle contractile apparatus) 2.6  NM_012134 mRNA sequence EPHB3 EphB3 (signal transduction) 2.6  NM_004443 OK/SW-CL.4 [Homo sapiens], mRNA sequence 4.4  BF056534 GATA3 GATA binding protein 3 (transcriptional regulation) 2.6  AI796169 FLJ34917 hypothetical protein FLJ34917 5.9  AC003682 LALBA lactalbumin, alpha- 2.7  NM_002289 Homo sapiens cDNA clone IMAGE:3943734 5', MRNA sequence 5.7  BE794962 RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.7  NM_002888 Human DNA sequence from clone CTA-390C10 on chromosome 5.6  AL008721 2+ 22q11.21-12.1, complete sequence NUCB1 nucleobindin 1 (Golgi Ca binding protein) 2.7  NM_006184 FLJ21135 hypothetical protein FLJ21135 5.5  NM_024866 HPSE Heparanase (inflammatory response) 2.7  NM_006665 Human DNA sequence from clone RP6-232G24 on chromosome 5.5  AL022152 KRT4 keratin 4 (cytoskeleton organization) 2.7  BE612352 Xq27.1-27.3 Contains the gene for tha melanoma antigen gene CENTB1 centaurin, beta 1 (regulates cytoskeletal & membrane trafficking events) 2.8  NM_014716 family protein, MAGEC3 and the MAGEC1 gene for melanoma PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 2.8  AL031680 antigen, family C,1, complete sequence (intracellular signaling) Homo sapiens cDNA FLJ12247 fis, clone MAMMA1001397 5.5  AK022309.1 ZMYND10 BLu protein 2.8  NM_015896 PRO3073 [Homo sapiens], mRNA sequence 5.4  NM_018549 ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.9  AI817942 Homo sapiens cDNA: FLJ21373 fis, clone COL03214, mRNA sequence 5.4  AK025026.1 KIAA0279 cadherin, EGF LAG seven-pass G-type receptor 2 2.9  D87469 Homo sapiens mRNA; cDNA DKFZp434C0814 (from 5.1  AL137654.1 (flamingo homolog, Drosophila) clone DKFZp434C0814), acid sphingomyelinase (SMPD1) 2.9  M81780 mRNA sequence KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 2.9  U39195.1 Homo sapiens mRNA; cDNA DKFZp434F1011 (from 5.1  AL157490.1 clone DKFZp434F1011), LAMA3 laminin, alpha 3 2.9  NM_000227 mRNA sequence BTBD2 BTB (POZ) domain containing 2 2.9  NM_017797 FLJ20130 hypothetical protein FLJ20130 5.1  NM_017681 RANBP3 RAN binding protein 3 2.9  NM_007321 FLJ13262 hypothetical protein FLJ13262 4.9  NM_024914 SARM sterile alpha and HEAT/Armadillo motif protein, ortholog of 3.0  AJ290445.1 Homo sapiens mRNA; cDNA DKFZp434E082 (from clone DKFZp434E082), 4.9  BF508639 Drosophila (signal transduction) mRNA sequence TNXB tenascin XB (extracellular matrix) 3.0  X71923.1 ESTs, Weakly similar to plakophilin 2 [Homo sapiens] [H.sapiens] 4.6  AA923707 DICER1 Dicer1, Dcr-1 homolog (Drosophila) (RNA processing) 3.0  AK001827.1 ESTs, Weakly similar to neuronal thread protein [Homo sapiens] 4.6  AW974481 RPL3L ribosomal protein L3-like 3.0  NM_005061 C20orf172 chromosome 20 open reading frame 172 4.6  NM_024918 KIAA0332 U2-associated SR140 protein 3.0  AB002330.1 Homo sapiens cDNA FLJ30367 fis, clone BRACE2007798, mRNA 4.5  BF348061 ZNFB7 tripartite motif-containing 15 3.0  U34249 FLJ13798 hypothetical protein FLJ13798 4.2  NM_024773 FRK fyn-related kinase 3.0  NM_002031 LOC90141 similar to CG11165 gene product 4.1  BC001787.1 TOX thymus high mobility group box protein TOX 3.1  AI961231 ESTs, Highly similar to uncharacterized hypothalamus protein HT010 4.1  AF119892.1 A2LP ataxin 2 related protein 3.1  NM_017492 [H.sapiens] PNAS-20 NB4 apoptosis related protein 3.1  AF274945.1 C1orf15 chromosome 1 open reading frame 15 3.9  AF288395.1 HSPG2 heparan sulfate proteoglycan 2 (perlecan) 3.1  M85289.1 NCF1 Homo sapiens cDNA clone IMAGE:2567625 3' similar to 3.9  AW072388 NUP210 nucleoporin 210 3.1  NM_024923 gb:M55067 NEUTROPHIL CYTOSOL FACTOR 1 (HUMAN);, MRNA sequence ZFP36L2 zinc finger protein 36, C3H type-like 2 (regulation of response to 3.1  AI356398 Homo sapiens mRNA; cDNA DKFZp434P2435 (from 3.9  AL117520.1 growth factors) clone DKFZp434P2435), mRNA sequence TPS1 tryptase, alpha 3.2  AF206666.1 Homo sapiens cDNA FLJ10586 fis, clone NT2RP2003986, mRNA 3.7  AK001448.1 TNS Tensin (signal transduction, actin x-linking, extracellular matrix attachment) 3.2  AF116610.1 Homo sapiens mRNA; cDNA DKFZp586L1824 (from clone 3.6  AL117663.1 FKHRL1P1 forkhead box O3A 3.3  AF032887 DKFZp586L1824), mRNA sequence PAX8 paired box gene 8 3.3  NM_013952 FLJ12571 hypothetical protein FLJ12571 3.5  NM_024926 NAGLU N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) 3.3  AI364950 FLJ12547 hypothetical protein FLJ12547 3.5  NM_024992 SCA1 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, 3.3  AW235612 Homo sapiens chromosome 19, CIT-HSP-146e8 3.4  AC005255 autosomal dominant, ataxin 1) Gene Fold change Genbank Gene Fold change Genbank Supplementary: unnamed, hypothetical genes, ESTs, ORFs etc. cont’d Supplementary: unnamed, hypothetical genes, ESTs, ORFs etc. cont’d AF038169 hypothetical protein AF038169 3.4  NM_013310 KIAA0169 KIAA0169 protein 2.3  BC005407.1 FLJ23550 hypothetical protein FLJ23550 3.3  NM_025063 Homo sapiens cDNA: FLJ21710 fis, clone COL10087, mRNA sequence 2.3  AK025363.1 FLJ20344 hypothetical protein FLJ20344 3.3  BG429154 Homo sapiens mRNA; cDNA DKFZp434N199 (from clone DKFZp434N199), 2.3  AL162040.1 Human DNA sequence from clone RP3-359N14 on chromosome 6q16.3-21 3.3  Z97206 mRNA sequence NDUFB3P5 Human DNA sequence from clone GS1-164F24 on chromosome 2.3  AL050308 Homo sapiens cDNA: FLJ22209 fis, clone HRC01496, mRNA sequence 3.3  AK025862.1 Xq26.3-27.3 Human DNA sequence from clone RP1-18C9 on chromosome 20 3.2  AL049709 Homo sapiens cDNA FLJ12192 fis, clone MAMMA1000851, 2.3  AK022254.1 Contains part of a novel gene similar to acetyl-coenzyme A synthetase, mRNA sequence a novel gene similar to Gamma-glutamyltranspeptidase, a gene similar FLJ22160 hypothetical protein FLJ22160 2.3  NM_024585 to HMG2a (high mobility group protein 2A), the 5' end of the AIB3 gene MGC5528 hypothetical protein MGC5528 2.3  NM_024094 for thyroid hormone receptor binding protein (KIAA0181), ESTs, STSs, GSSs, CpG Islands and the D20S101 marker Homo sapiens cDNA: FLJ23067 fis, clone LNG04993, mRNA sequence 2.3  AK026720.1 KIAA1660 KIAA1660 protein 3.2  AB051447.1 C20orf149 chromosome 20 open reading frame 149 2.3  NM_024299 FLJ21511 hypothetical protein FLJ21511 3.2  NM_025087 Homo sapiens, clone IMAGE:4711494, mRNA, mRNA sequence 2.4  BF575213 EIF3S7; Human DNA sequence from clone RP5-1119A7 on chromosome 3.2  AL022313 Homo sapiens cDNA FLJ36630 fis, clone TRACH2018278, mRNA 2.4  U21915.1 MGC17258; 22q12.2-12.3 DKFZp762C18 hypothetical protein DKFZp762C186 2.4  BG334196 eIF3-p66; eIF3- 6 zeta Homo sapiens cDNA FLJ14067 fis, clone HEMBB1001315 2.4  AK024129.1 FLJ10035 hypothetical protein FLJ10035 3.2  NM_017974 Homo sapiens cDNA FLJ12325 fis, clone MAMMA1002125, 2.4  AK022387.1 Homo sapiens clone 23705 mRNA sequence 3.1  Z39557 mRNA sequence glutamine synthetase pseudogene 3.1  U08626 Homo sapiens cDNA FLJ11552 fis, clone HEMBA1003021, 2.4  AK021614.1 Human DNA sequence from clone RP1-179E13 on chromosome 3.1  AL035603 mRNA sequence 6q22.1-22.33 Homo sapiens cDNA FLJ11819 fis, clone HEMBA1006426, 2.4  AK021881.1 C20orf27 chromosome 20 open reading frame 27 3.1  NM_017874 mRNA sequence KIAA0239 KIAA0239 protein 2.4  NM_015288 DKFZP434G22 hypothetical protein DKFZp434G2226 3.0  NM_031217 26 HCGIV-6 HCGIV-6 protein 2.4  AF036973 KIAA1473 KIAA1473 protein 2.9  AB040906.1 FLJ14298 hypothetical protein FLJ14298 2.5  NM_024764 KIAA0451 KIAA0451 gene product 2.9  AK027000.1 C20orf103 chromosome 20 open reading frame 103 2.6  NM_012261 MGC20727 hypothetical protein MGC20727 2.9  BF509069 Human clone 23932 mRNA sequence 2.6  U79257.1 FLJ11117 hypothetical protein FLJ11117 2.9  NM_018329 WINS1 hypothetical protein FLJ10583 2.6  NM_018148 Homo sapiens clone 24421 mRNA sequence 2.9  AF070641.1 KIAA1102 KIAA1102 protein 2.6  AK027231.1 FLJ11183 hypothetical protein FLJ11183 2.9  NM_018351 KIAA0561 KIAA0561 protein 2.6  AB011133.1 Homo sapiens cDNA FLJ13754 fis, clone PLACE3000362,mRNA 2.8  AK023816.1 KIAA0963 KIAA0963 protein 2.6  NM_014963 Homo sapiens mRNA; cDNA DKFZp434E2028 (from clone 2.8  AL133089.1 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 46866, 2.7  AL109674.1 DKFZp434E2028), mRNA sequence mRNA sequence ESTs, Weakly similar to PRPP_HUMAN SALIVARY PROLINE-RICH 2.7  AI907083 MGC14258 hypothetical protein MGC14258 2.8  U79256 PROTEIN Homo sapiens cDNA: FLJ21735 fis, clone COLF3350, mRNA sequence 2.8  AK025388.1 II-1 [H.sapiens] Homo sapiens cDNA FLJ12683 fis, clone NT2RM4002457, mRNA 2.7  AA827892 PRO0899 hypothetical protein PRO0899 2.8  NM_018565 MDS028 uncharacterized hematopoietic stem/progenitor cells protein MDS028 2.7  NM_018463 Homo sapiens mRNA; cDNA DKFZp564A023 (from clone DKFZp564A023), 2.7  AL049233.1 mRNA sequence HSPC072 HSPC072 protein 2.7  NM_014162 an31a09.x1 Gessler Wilms tumor Homo sapiens cDNA 2.7  AI050036 Homo sapiens mRNA; cDNA DKFZp564I066 (from clone DKFZp564I066), 2.9  AL049331.1 clone IMAGE:1700248 3' mRNA sequence C20orf40 chromosome 20 open reading frame 40 2.7  NM_014054 FLJ12616 hypothetical protein FLJ12616 2.9  NM_024995 PHF3 cDNA clone IMAGE:2675443 3' similar to TR:Q92576 2.7  AW189430 FLJ10619 hypothetical protein FLJ10619 2.9  NM_018156 Q92576 MYELOBLAST KIAA0244 ESTs 2.9  AW974666 MGC2508 hypothetical protein MGC2508 2.7  AA639585 KIAA0542 KIAA0542 gene product 3.0  AB011114.2 FLJ20014 hypothetical protein FLJ20014 2.7  NM_017622 FLJ13852 hypothetical protein FLJ13852 3.1  NM_023078 FANCA hypothetical protein MGC45417 2.7  AW083279 C14orf58 chromosome 14 open reading frame 58 3.1  NM_017791 FLJ10210 hypothetical protein FLJ10210 2.6  NM_018027 PRO1097 [Homo sapiens], mRNA sequence 3.1  NM_018499 Homo sapiens cDNA FLJ13833 fis, clone THYRO1000676, 2.6  AK023895.1 ESTs, Weakly similar to hypothetical protein FLJ20489 [H.sapiens] 3.1  AF113018.1 mRNA sequence FLJ11101 hypothetical protein FLJ11101 2.6  NM_018322 3.1  BE892698 DKFZP564C19 DKFZP564C196 protein 2.6  AA417256 RPS20 Homo sapiens cDNA clone CS0DI080YN02 3-PRIME 3.2  AL576654 6 Homo sapiens cDNA FLJ34019 fis, clone FCBBF2002898, mRNA 3.2  AA995925 TNRC9 trinucleotide repeat containing 9 2.6  U80736.1 HSPC049 HSPC049 protein 3.2  NM_014149 FLJ32069 hypothetical protein FLJ32069 2.6  AW451711 FLJ00001 hypothetical protein FLJ00001 3.3  BC000122.1 FLJ12921 hypothetical protein FLJ12921 2.5  NM_024875 Homo sapiens clones 24714 and 24715 mRNA sequence 3.3  AF070541.1 HSPC134 HSPC134 protein 2.5  NM_014169 Homo sapiens mRNA; cDNA DKFZp586E121 (from clone DKFZp586E121), 3.3  AL050122.1 KIAA1096 KIAA1096 protein 2.5  AL096857.1 mRNA sequence Homo sapiens clone DT1P1A11 mRNA, CAG repeat region, 2.5  U92992.1 FLJ23231 hypothetical protein FLJ23231 3.3  NM_025079 mRNA sequence FLJ39639 Unnamed protein product [Homo sapiens], mRNA sequence 3.3  AI732770 LOC55954 hypothetical protein LOC55954 2.5  NM_019103 FLJ23022 hypothetical protein FLJ23022 3.4  NM_025051 PRO0131 [Homo sapiens], mRNA sequence 2.5  AF090896.1 ESTs, Weakly similar to hypothetical protein FLJ20378 [H.sapiens] 3.4  AF116715.1 6M1-4P*01 Homo sapiens 6M1-4P*01 pseudogene, cell line LG2 2.4  AJ302559 Homo sapiens clone 24566 mRNA sequence 3.4  AF070536.1 KIAA0527 KIAA0527 protein 2.4  BF977837 Homo sapiens cDNA clone IMAGE:1967179 3' similar to contains 3.4  AI246331 FLJ23033 hypothetical protein FLJ23033 2.4  NM_024686 Alu repetitive element Homo sapiens cDNA: FLJ21690 fis, clone COL09538, mRNA sequence 2.4  AK025343.1 FLJ20721 hypothetical protein FLJ20721 3.4  NM_017941 Homo sapiens cDNA: FLJ21533 fis, clone COL06072, mRNA sequence 2.4  BE965029 RPL34P2 clone RP1-181J22 on chromosome 11p13 3.6  AL049714 FLJ13105 hypothetical protein FLJ13105 2.4  NM_025001 Unnamed protein product [Homo sapiens], mRNA sequence 3.6  NM_025050 KIAA0874 KIAA0874 protein 2.4  X80821.1 Homo sapiens cDNA FLJ14113 fis, clone MAMMA1001715, 3.7  AK024175.1 mRNA sequence NKTR Homo sapiens, Similar to natural killer tumor recognition sequence, 2.3  AI688640 Homo sapiens, clone IMAGE:4291354, mRNA, mRNA sequence 3.7  AW974823 clone IMAGE:5550348, mRNA, mRNA sequence HYA22 HYA22 protein 2.3  BF031714 KIAA0237 KIAA0237 gene product 3.7  NM_014747 LOC57090 HRPAP20 short form 2.3  NM_020355 KIAA0363 KIAA0363 protein 3.7  AB002361.1 Homo sapiens cDNA FLJ11022 fis, clone PLACE1003771, mRNA sequence 2.3  R33964 Homo sapiens cDNA FLJ13856 fis, clone THYRO1000988, mRNA 3.7  AK023918.1 RLP49 hypothetical protein LOC57333 2.3  NM_020650 Homo sapiens mRNA; cDNA DKFZp564E193 (from clone DKFZp564E193), 3.8  AL049259.1 mRNA sequence MGC12458 hypothetical protein MGC12458 2.3  BC002836.1 Homo sapiens cDNA FLJ13453 fis, clone PLACE1003205, mRNA 4.0  AK023515.1 FLJ23548 hypothetical protein FLJ23548 2.3  NM_024590 FLJ12089 hypothetical protein FLJ12089 4.0  NM_024552 DKFZP564F01 hypothetical protein DKFZp564F013 2.3  AL136883.1 MGC33190 hypothetical protein MGC33190 4.0  AI017382 3 MGC10986 hypothetical protein MGC10986 2.2  NM_030576 H.sapiens GENX-5624 mRNA, 3' UTR, mRNA sequence 4.2  X81895.1 PRO1575 PRO1575 protein 2.2  NM_014092 ESTs, Highly similar to hypothetical protein PRO2266 [H.sapiens] 4.2  NM_018519 MGC11061 hypothetical protein MGC11061 2.2  BE999993 PRO0456 PRO0456 protein 4.2  NM_014127 FLJ21369 hypothetical protein FLJ21369 2.1  NM_024802 ESTs, Weakly similar to hypothetical protein FLJ20489 H.sapiens] 4.2  AW574933 Homo sapiens cDNA: FLJ21618 fis, clone COL07487, mRNA sequence 2.1  AK025271.1 KIAA0841 KIAA0841 protein 4.2  AW189966 VDAC1 gene Homo sapiens VDAC1 pseudogene 2.1  AJ002428 Homo sapiens mRNA; cDNA DKFZp586E1120 (from clone 4.2  AL049437.1 DKFZp586E1120), KIAA0152 KIAA0152 gene product 2.1  BC000371.1 mRNA sequence FLJ10661 hypothetical protein FLJ10661 2.1  NM_018172 HSU79303 protein predicted by clone 23882 4.2  NM_013301 FLJ12076 hypothetical protein FLJ12076 2.1  NM_025187 FLJ22419 hypothetical protein FLJ22419 4.2  NM_024697 FLJ12584 hypothetical protein FLJ23510 2.1  NM_025139 Unknown (protein for IMAGE:3354344) [Homo sapiens], mRNA sequence 4.2  BG403790 FLJ10377 hypothetical protein FLJ10377 2.1  NM_018077 ESTs, Weakly similar to hypothetical protein FLJ20489 [H.sapiens] 5.0  AF113683.1 Human DNA sequence from clone RP1-115K14 on chromosome Xq22.3-23 2.0  AL034450 Homo sapiens cDNA: FLJ21920 fis, clone HEP04049, mRNA sequence 5.0  AK025573.1 Similar to hypothetical protein PRO2831 [Homo sapiens], mRNA sequence 2.0  BE671816 EST380405 MAGE resequences, MAGJ Homo sapiens cDNA, MRNA 5.0  AW968210 Human DNA sequence from clone RP4-581F12 on chromosome Xq21 2.0  AL031313 sequence C5orf5 chromosome 5 open reading frame 5 2.0  NM_016603 MGC12904 hypothetical protein MGC12904 5.3  NM_031219 FLJ23469 hypothetical protein FLJ23469 2.0  NM_024710 Homo sapiens cDNA FLJ35653 fis, clone SPLEN2013690, mRNA sequence 5.3  AI161338 FLJ12056 hypothetical protein FLJ12056 2.0  AK022118.1 KIAA0708 KIAA0708 protein 5.3  AB014608.1 FLJ20047 hypothetical protein FLJ20047 2.0  NM_017639 Homo sapiens cDNA FLJ14111 fis, clone MAMMA1001630, mRNA 5.3  AK024173.1 sequence KIAA1009 KIAA1009 protein 2.0  AK023613.1 GRTP1 hypothetical protein FLJ22474 5.6  NM_024719 KIAA0916 KIAA0916 protein 2.0  AA488899 TSLL2 TSLC1-like 2 5.6  AC005525

KIAA1069 KIAA1069 protein 5.6  AK022610.1 KIAA0182 KIAA0182 protein 2.0  D80004.1 ESTs, Moderately similar to TBB2_HUMAN Tubulin beta-2 chain [H.sapiens] 5.6  AI433261 FLJ10346 hypothetical protein FLJ10346 2.0  NM_018065 FLJ13188 hypothetical protein FLJ13188 5.8  NM_022063 Homo sapiens cDNA: FLJ21284 fis, clone COL01911, mRNA sequence 2.0  AK024937.1 PP1200 [Homo sapiens], mRNA sequence 5.9  AF202635.1 Homo sapiens mRNA; cDNA DKFZp547N074 (from clone DKFZp547N074), 2.1  AL390143.1 Homo sapiens mRNA; cDNA DKFZp434M1812 (from clone 5.9  AL137624.1 mRNA sequence DKFZp434M1812), FLJ10038 hypothetical protein FLJ10038 2.1  NM_017976 mRNA sequence FLJ11743 hypothetical protein FLJ11743 2.1  NM_024527 FLJ21195 hypothetical protein FLJ21195 similar to protein related to DAC and 5.9  NM_022469 Homo sapiens clone IMAGE 23915, mRNA sequence 2.1  AF090100.1 cerberus LOC282997 Unnamed protein product [Homo sapiens], mRNA sequence 2.1  AI695595 Homo sapiens mRNA; cDNA DKFZp564I153 (from clone DKFZp564I153), 6.3  AL049278.1 Homo sapiens cDNA FLJ30991 fis, clone HLUNG1000041, mRNA 2.1  AL033538 mRNA sequence Homo sapiens mRNA; cDNA DKFZp564H1916 (from clone 6.3  AL110126.1 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 21920, 2.1  AL109696.1 DKFZp564H1916), mRNA sequence mRNA sequence C20orf67 chromosome 20 open reading frame 67 2.1  AI199589 Homo sapiens mRNA; cDNA DKFZp586F1024 (from clone 6.3  BF574664 FLJ21269 hypothetical protein FLJ21269 2.1  NM_025107 DKFZp586F1024), Homo sapiens cDNA clone IMAGE:2716145 3' 2.1  AW138374 mRNA sequence Homo sapiens cDNA FLJ13776 fis, clone PLACE4000387 2.2  AK023838.1 Homo sapiens mRNA; cDNA DKFZp566F1224 (from clone 6.3  AL050032.1 DKFZp566F1224), Homo sapiens cDNA FLJ38835 fis, clone MESAN2002424, 2.2  N21364 mRNA sequence mRNA sequence Similar to hemopexin [Homo sapiens], mRNA sequence 7.1  BC005395.1 R32184_3 hypothetical protein MGC4022 2.2  AC004528 KIAA1305 KIAA1305 protein 7.1  NM_025081 Homo sapiens cDNA FLJ11505 fis, clone HEMBA1002139, 2.2  R78299 mRNA sequence KIAA0729 protein [Homo sapiens], mRNA sequence 7.1  AK023845.1 Homo sapiens mRNA; cDNA DKFZp434K052 (from clone 2.2  AL137398.1 p64 chloride channel protein (p64) pseudogene 7.7  U85978 DKFZp434K052), mRNA sequence FLJ23047 hypothetical protein FLJ23047 7.7  NM_024548 Homo sapiens mRNA; cDNA DKFZp564J2116 (from clone 2.2  AL110190.1 SIM1 clone RP3-399E4 on chromosome 6. Contains the 3' end of the SIM1 8.3  AL121948 DKFZp564J2116), gene for single-minded (Drosophila) homolog 1, ESTs, STSs and GSSs mRNA sequence PRO1853 hypothetical protein PRO1853 9.1  NM_018607 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1977059, 2.2  NM_003107.1 mRNA sequence FLJ12294 hypothetical protein FLJ12294 10.0  NM_025100 Homo sapiens clone case06H1 immunoglobulin heavy chain 2.2  AF168811 PP1665 hypothetical protein PP1665 10.0  AL041124 variable region gene Gene Fold change Genbank Supplementary: unnamed, hypothetical genes, ESTs, ORFs etc. cont’d Homo sapiens cDNA FLJ14096 fis, clone MAMMA1000752, 12.5  AK024158.1 mRNA sequence KIAA0987 erythrocyte membrane protein band 4.1-like 3 14.3  NM_012307 AF15Q14 AF15q14 protein 16.7  NM_020380 MGC10848 hypothetical protein MGC10848 25.0  NM_030569