Volume 15: Issue 10 June 30, 2014

NEUROSURGE

MONTHLY INFORMATION FROM THE CHAIRMAN'S OFFICE UNIVERSITY OF TORONTO, DIVISION OF

In This Issue:

From the Chairman's Office Honors, Grants and Awards Publications Visiting Professorships In the Media Faculty Focus PDFs of the Month Upcoming Meetings Residents’ Corner

FROM THE CHAIRMAN’S OFFICE

On June 12-13, we welcomed Dr. Franco De Monte, Professor and Vice Chair of the Department of Surgery at the University of Texas MD Anderson Cancer Center, as our 39th William S. Keith Visiting Professor at Toronto Western Hospital. Dr. De Monte delivered two excellent surgical lectures, the first entitled “Anterolateral Skull Base Surgery” on June 12 and the Royal College of Physicians and Surgeons of Canada Lecture entitled “Malignancy of the Skull Base: Surgical Outcomes and Limitations” on June 13. Dr. De Monte also served on the judging panel for the annual Morley Prize competition for best resident research paper presentations, won by George Ibrahim (PGY4). We thank this year’s Keith Lectureship Program Chair Gelareh Zadeh and Ms. Sandi Amaral for organizing this successful event.

The Keith Dinner combined with a graduation ceremony for the PGY6 residents and for our city- wide fellows was hosted by the Division of Neurosurgery at TWH at Far Niente Restaurant. Opening remarks were provided by TWH Division Head Michael Tymianski. Division Chair Andres Lozano and Residency Program Director Abhaya Kulkarni presented the residents with framed photographs taken with their mentors, while fellows were presented with fellowship completion certificates by Gelareh Zadeh and Andres Lozano. The Alan Hudson Teaching Awards were announced, with Dr. Kulkarni winning the Hudson Faculty Teaching Award and Safraz Mohammed (PGY5) receiving the Hudson Resident Teaching Award. This year’s Warren Ho Humanitarian Award was presented to George Ibhrahim (PGY4).

On June 27, we welcomed Dr. Peter Vajkoczy (Director, Department of Neurosurgery, Charite Universitätsmedizin, Berlin) as the 2014 City-Wide Rounds speaker hosted by Sunnybrook Hospital. Dr. Vajkoczy delivered an engaging lecture entitled “Moyamoya in Europe”, which was followed by case presentations by our residents. We thank Dr. Leo da Costa (Head, Division of Neurosurgery, St. Michael’s Hospital) with assistance from Ms. Laura Vasco for organizing this excellent event.

Julian Spears was appointed as Term Chair, Cerebrovascular and Brain Tumour Surgery at St. Michael's Hospital. The initial term is for five years and is renewable. Congratulations, Julian.

Michael Fehlings was elected to the Canadian Academy of Health Sciences (CAHS). Fellows elected to the Academy are well recognized by their peers nationally and internationally for their contributions to the promotion of health science.

Michael Fehlings was elected as a Fellow of the . Fellows are nominated for exceptional achievements through a body of publications, intellectual endeavours or creative activities exhibiting original contributions in the arts, humanities or sciences, as well as in public life. The distinction will be conferred in the fall.

Andres Lozano was appointed to the rank of University Professor, the most prestigious and distinguished rank at the University of Toronto. He now joins the notable ranks of Tirone David, and Robert Salter as surgeons who have received University Professor status.

Andres Lozano was identified by Thomson Reuters Essential Science Indicators as a Highly Cited Researcher (http://highlycited.com/) and as the most highly cited neurosurgeon in the world for the eleven-year period from 2002 to 2012. He was also included on the Thompson Reuters ScienceWatch 2014 World’s Most Influential Scientific Minds listing. http://sciencewatch.com/sites/sw/files/sw-article/media/worlds-most-influential-scientific-minds-2014.pdf

Todd Mainprize received the Marvin Tile Distinguished Service Award at Sunnybrook Hospital, given to an individual who has contributed significantly in the areas of teaching, research and professional activity within the Department of Surgery.

Karen Davis was awarded the Mel Silverman Mentorship Award by the Institute of Medical Science (IMS) at the University of Toronto. The Award is presented to an IMS graduate faculty member who has served as an outstanding mentor and role model for graduate students, and who has contributed in a significant way to the IMS graduate program

We extend congratulations to our PGY6 residents—Julius Ebinu, Aria Fallah, Carlo Santaguida, Mehdi Shahideh and Sunjay Sharma—who completed the neurosurgical residency programme and passed the Royal College examinations. Julius will pursue a neurooncology fellowship at Toronto Western Hospital. Aria has accepted a pediatric neurosurgery fellowship at the University of Miami. Carlo will begin a spine fellowship with Dr. Michael Fehlings’ group. Mehdi will be launching his career on the staff of Trillium Health Partners in Mississauga. Sunjay will pursue critical care fellowship training at McMaster University. The faculty, fellows and residents convey their congratulations and best wishes to our graduates as they embark on the next stages of their careers.

On June 7, the Division of Neurosurgery participated in the 11th Annual Neurosurgery Charity Softball Tournament in New York City. Our team, the sole Canadian group, gave a valiant effort in the face of fierce competition amongst the thirty competing programs from across North America. Practices are already underway for next year, thanks to the efforts of Abhaya Kulkarni and Alireza Mansouri (PGY3).

As we reach the end of 2013-14 academic year, we can reflect on another year of strong accomplishments and growth. We recruited Suneil Kalia as our newest Faculty member at Toronto Western Hospital, and we thanked Paul Muller and Michael Schwartz for their years of dedicated service and leadership following their retirement from stellar careers in neurosurgical practice, research and education. We have again earned some of the most prestigious awards and leadership positions in our discipline. We were delighted by developments in endowed chairs across our city-wide Division, with Michael Taylor and Peter Dirks receiving Garron Family Chairs in Childhood Cancer Research at the Hospital for Sick Children, Fred Gentili taking on the Hudson Chair in Neurooncology at Toronto Western, and Julian Spears being appointed as the Term Chair in Cerebrovascular and Brain Tumour Surgery at St. Michael’s Hospital. We celebrated 90 Years of Neurosurgery at the University of Toronto, welcoming home our alumni from around the world. With sadness we said goodbye to dear mentors and friends, the late Drs. Ross Fleming and William Feindel. To each of our outstanding Faculty, fellows, residents and alumni, I thank you for your dedication and contributions that have made Toronto Neurosurgery the standard to which other programs are held around the world. Please see below for more highlights from 2013-14.

2014 Keith Lectureship Dinner and Graduation Ceremony. Attendees gathered at Far Niente Restaurant for an evening of excellent food and conversations, and presentation of Division awards.

2014 Division of Neurosurgery Softball Team. Back row: Nicolas Phan, Eric Thompson, Suganth Suppiah, Newton Cho, Deep Guha, Christopher Witiw, Alireza Mansouri, Todd Mainprize, James Rutka, David Cadotte, Dennis Izukawa. Front row: Ying Meng, Mehdi Shahideh, Sumit Jhas, Graham Mainprize, Abhaya Kulkarni, Carlo Santaguida.

THE YEAR IN REVIEW: 2013-2014 MAJOR EVENTS AND ACCOMPLISHMENTS

1. We welcomed Suneil Kalia to the Neurosurgical Faculty at Toronto Western Hospital as of September 1, 2013. His wife Lorraine Kalia, a neurodegenerative disease researcher and a movement disorders neurologist, was also recruied to Toronto Western Hospital.

2. On July 1, 2013, Drs. Paul Muller (St. Michael’s Hospital) and Michael Schwartz (Division Head, Sunnybrook Hospital), retired from neurosurgical practice after distinguished careers at their respective hospitals. We thank them for their many years of outstanding leadership service.

3. James Rutka, R.S. McLauglin Chair of the Department of Surgery, University of Toronto, was elected to the Order of Ontario, the Province's highest honour.

4. Michael Fehlings was appointed as Vice Chair Research in the Department of Surgery at the University of Toronto.

5. Andres Lozano received the 2013 Margolese National Prize in Brain Disorders, awarded to a Canadian who has transformed care in heart and brain diseases.

6. Michael Taylor and Peter Dirks at the Hospital for Sick Children received Garron Family Chairs in Childhood Cancer Research. We are proud that are Neurosurgery Faculty can compete successfully with non-surgeon scientists for these highly competitive research chairs.

7. Visiting Professors at the University of Toronto included:

- John Kestle, University of British Columbia, 28th E. Bruce Hendrick Visiting Professorship in Pediatric Neurosurgery, Oct. 8, 2013 - Juan C. Fernandez-Miranda, University of Pittsburgh, 46th Lougheed Microsurgical Course, Oct. 28-Nov. 1, 2013 - Sebastien Froelich, Hôpital Lariboisière, Paris, 47th Lougheed Microsurgical Course, Mar. 31-Apr 3, 2014. - Sebastien Froelich, Hôpital Lariboisière, Paris, City-Wide Rounds at Toronto Western Hospital, Apr. 3, 2014. - Howard Riina, NYU Langone Medical Center, City-Wide Rounds at St. Michael’s Hospital, May. 23, 2014 - Franco De Monte, MD Anderson Cancer Center, 39th William S. Keith Visiting Professorship, Jun. 12-13, 2014 - Peter Vajkoczy, Charite Universitätsmedizin, Berlin, City-Wide Rounds at Sunnybrook Hospital, Jun. 27, 2014

8. On September 13-15, 2013, fourteen Neurosurgery residents along with Andres Lozano and Eric Massicotte took part in a Division cottage weekend near Parry Sound. Attendees took part in boating, swimming, hiking and a pub night—and enjoyed socializing in the great outdoors.

9. On October 6, 2013, we began a celebration of 90 Years of Neurosurgery at the University of Toronto with a three-day event attended by over 250 participants, including special guests Mr. Leslie and Anna Dan, Dr. Michael and Amira Dan, Dr. Catharine Whiteside (Dean, Faculty of Medicine, University of Toronto), Dr. Barry McLellan (CEO, Sunnybrook Hospital), Dr. Mary Jo Haddad (CEO, Hospital for Sick Children), Dr. Shaf Keshavjee (Surgeon-in-Chief, University Health Network), Dr. Michael Julius (VP Research, St. Michael’s Hospital) and Dr. Christopher Paige (VP Research, University Health Network). Two days of excellent scientific talks were given at the Telus Centre for Performance and Learning by over 30 speakers in sessions on History (Chair, Dr. Andres Lozano), Cerebrovascular (Co-Chairs, Drs. Loch Macdonald and Michael Tymianski), Functional (Chair, Dr. Andres Lozano), Spine (Chair, Dr. Michael Fehlings), Neurooncology (Co- Chairs, Drs. Mark Bernstein and Todd Mainprize) and Pediatrics (Chair, Dr. James Drake). Attendees and alumni enjoyed reconnecting at a welcome reception, gala dinner at the Liberty Grand and a lunch at Hart House and were treated to splendid written accounts of the recollections of training by our Emeritus and distinguished senior Faculty, many of whom were in attendance. The full set of event photos can be accessed at: https://drive.google.com/folderview?id=0B__z8-AL2W4bjgwNFVoNDNMWDg&usp=sharing

10. We were saddened by the passing of Dr. J.F. Ross Fleming, MD, MSc, FRCSC, FACS, past Professor Emeritus in our Division, on December 1, 2013 and of Dr. William Feindel, O.C., G.O.Q., MDCM, D. Phil., one of Canada's most distinguished neurosurgeons and third Director of the Neurological Institute, on January 12, 2014. Their made enduring contributions to Canadian neurosurgery and will be deeply missed.

11. January 10, 2014 marked the first Skype broadcast by the University of Toronto Brain School to the Neurosurgery Program in Kijabe, Kenya, as part of International Surgery Rounds. We thank Alireza Mansouri (PGY3) for his efforts in this initiative.

12. Fred Gentili was appointed as the Alan and Susan Hudson Chair in Neuro-Oncology at University Health Network.

13. On February 24, 2014, our Division held its first Cerebrovascular Neurosurgery Soiree with Faculty participation from each of our four hospitals. Attendees presented developments in clinical, research and teaching work at their sites, and discussed opportunites for new synergies across the University-wide program. The event was followed by Soirees for Neurooncology (March 3), Spine (April 14) and Gamme Knife Surgery (May 26).

14. Gelareh Zadeh was appointed to the new role of Director of Academic Affairs for the University of Toronto Division of Neurosurgery effective March 1, 2014.

15. George Ibrahim (PGY4) and Shobhan Vachrajani (PGY5) won the 2013 K.G.McKenzie Prizes in Clinical Neuroscience Research, the most prestigious resident awards in our discipline in Canada. Toronto Neurosurgery continued its historically strong performance in this competition, having won 22 of the 37 McKenzie Prizes (59.5%) awarded since 2000.

16. delivered the inaugural Charles Tator Honorary Lectureship on Spinal Trauma at the Annual Scientific meeting of the American Association of Neurological Surgeons (AANS) in San Franciso.

17. Michael Cusimano led the development of a new research opportunity in Quality and Best Practices in Neurosurgery, including knowledge translation and implementation science, for our city-wide Division. We thank Dr. Cusimano for spearheading this initiative.

18. The Weston Brain Institute was launched on May 15, 2014 with Andres Lozano serving as the Chair of the Scientific Advisory Committee. Created by the W. Garfield Weston Foundation, $50 milllion Institute is believed to be the largest privately financed initiative targeting brain disease in Canada.

19. The Marion and Gerald Soloway Chair in Brain Injury and Concussion Research at Toronto Western Hospital/University Health Network was announced by Charles Tator at a special event on May 28, 2014. The Soloways contributed $2 million to create the endowed Chair in honour of their lifelong friend, Dr. Tator—who with the Toronto General & Western Hospital Foundation have committed to raise an additional $2 million via fundraising.

20. Gelareh Zadeh won 2014 Surgeon-Scientist Award, presented annually to an outstanding graduate of the Surgeon-Scientist Training Program in the Department of Surgery at University of Toronto who shows the greatest promise for a career in academic surgery.

21. David Cadotte (PGY4) received the Gallie Bateman Award, 1st Place, for the top paper presented by a Surgeon-Scientist Program trainee in the Department of Surgery.

22. On May 27, 2014, a dinner was hosted in appreciation of Dr. Michael and Amira Dan, whose generosity led to the establishment of the Dan Fellows in Neurosurgery program at the University of Toronto, now in its second year. Our 2013-14 Dan Fellows (Menno Germans, St. Michael’s Hospital and Amancio Maldonado, Toronto Western Hospital) were invited to have an opportunity to discuss how the Fellowships have impacted their training goals and career aspirations. We are extremely grateful to the Dan Family for their strong ongoing commitment to neurosurgical education and excellence in Toronto.

23. Todd Mainprize received the Marvin Tile Distinguished Service Award at Sunnybrook Hospital.

24. Gelareh Zadeh won the 2014 Wightman-Berris Academy Postgraduate Education Teaching Excellence Award.

25. Karen Davis was awarded the Institute of Medical Science Mel Silverman Mentorship Award.

26. Michael Fehlings was elected to the Canadian Academy of Health Sciences.

27. Julian Spears was appointed as Term Chair, Cerebrovascular and Brain Tumour Surgery at St. Michael's Hospital.

28. Andres Lozano was appointed to the rank of University Professor at the University of Toronto.

29. Michael Fehlings was elected to the Royal Society of Canada.

30. Number of publications by neurosurgery faculty and residents = 328

31. Number of New Grant Awards, Faculty = 19

32. Nubmer of New Fellowship Awards, Residents = 5

33. Number of Visiting Professorships by Faculty = 145

34. New Fellows of the Royal College of Surgeons of Canada = 5

HONOURS, GRANTS AND AWARDS – JUNE 2014

David Cadotte (Supervisor: Michael Fehlings) successfully defended his PhD Oral Examination on May 26, 2014 for his thesis “Development of novel magnetic resonance imaging techniques to evaluate plasticity in the injured human cervical spinal cord.”

Karen Davis was awarded the Institute of Medical Science Mel Silverman Mentorship Award.

Karen Davis's TED-Ed education video went online on June 2 and has been viewed more than 400,000 times on YouTube entitled: "How does your brain respond to pain"

Michael Fehlings has been elected as a Fellow of the Canadian Academy of Health Sciences.

Michael Fehlings was elected as a Fellow of the Royal Society of Canada.

Michael Fehlings has been awarded a grant from the Wings for Life Spinal Cord Research Foundation for 2014-15 in the amount of 77,340€ for his project entitled “An examination of the therapeutic impact of human induced pluripotent stem cell derived neural precursor cells in cervical spinal cord injury.

Michael Fehlings has been awarded a 2014-15 Spine Section – Post-Residency Clinical Fellowship Grant in the amount of US$67,937.50 from the American Association of Neurological Surgeons / Neurosurgery Research & Education Foundation.

Mojgan Hodaie is the Canadian lead of the Genetics of Trigeminal Neuralgia, a multicenter study spearheaded by OHSU, Oregon Health and Science University.

Andres Lozano was appointed to the rank of University Professor at the University of Toronto.

Andres Lozano received the 2014 Canadian College of Neuropsychopharmacology (CCNP) Innovations Award, in recognition of outstanding and innovative research in the basic or clinical fields of neuropsychopharmacology.

Todd Mainprize received the Marvin Tile Distinguished Service Award from Sunnybrook Hospital.

PUBLICATIONS – JUNE 2014

Ahmed N, Devitt KS, Keshet I, Spicer J, Imrie K, Feldman L, Cools-Lartigue J, Kayssi A, Lipsman N, Elmi M, Kulkarni AV, Parshuram C, Mainprize T, Warren RJ, Fata P,Gorman MS, Feinberg S, Rutka J. A systematic review of the effects of resident duty hour restrictions in surgery: impact on resident wellness, training, and patient outcomes. Ann Surg. 2014 Jun;259(6):1041-53.

Asbridge M, Mann R, Cusimano MD, Tallon JM, Pauley C, Rehm J. Cycling-related crash risk and the role of cannabis and alcohol: a case-crossover study. Prev Med. 2014 Jun 16.

Bhandari M, Guyatt GH, Kulkarni AV, Devereaux PJ, Leece P, Bajammal S,Heels-Ansdell D, Busse JW. Perceptions of authors' contributions are influenced by both byline order and designation of corresponding author. J Clin Epidemiol. 2014 Jun 25.

Cruz JP, Sahgal A, Whyne C, Fehlings MG, Smith R. Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease. J Neurosurg Spine. 2014 Jun 6:1-6.

DeSouza DD, Hodaie M, Davis KD. Response to Letter to the Editor. Pain. 2014 May 28.

Di Ieva A, Bruner E, Haider T, Rodella LF, Lee JM, Cusimano MD, Tschabitscher M. Skull base embryology: a multidisciplinary review. Childs Nerv Syst. 2014 Jun;30(6):991-1000.

Etminan N, Macdonald RL. Medical Complications after Aneurysmal Subarachnoid Hemorrhage - An Emerging Contributor to Poor Outcome. World Neurosurg. 2014 Jun 17.

Furlan JC, Chui MH, Croul SE, Kongkham P. Mystery Case: Tanycytic ependymoma of the conus medullaris: A rare cause of low back pain. Neurology. 2014 Jun 17;82(24):e212-3.

Forget A, Bihannic L, Cigna SM, Lefevre C, Remke M, Barnat M, Dodier S,Shirvani H, Mercier A, Mensah A, Garcia M, Humbert S, Taylor MD, Lasorella A, Ayrault O. Shh signaling protects atoh1 from degradation mediated by the e3 ubiquitin ligase huwe1 in neural precursors. Dev Cell. 2014 Jun 23;29(6):649-61.

Forgione N, Karadimas SK, Foltz WD, Satkunendrarajah K, Lip A, Fehlings M. Bilateral Contusion-Compression Model of Incomplete Traumatic Cervical Spinal Cord Injury (SCI). J Neurotrauma. 2014 Jun 20.

Hawryluk GW, Furlan JC, Austin JW, Fehlings MG. Individual characteristics and management decisions affect outcome of anticoagulated patients with intracranial hemorrhage. World Neurosug. 2014 May-June;81(5-6):742-751.

Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26;510(7506):537-41.

Ibrahim GM, Rutka JT, Snead OC. Epilepsy surgery in childhood: no longer the treatment of last resort. CMAJ. 2014 Jun 9.

Jalali S, Chung C, Foltz W, Burrell K, Singh S, Hill R, Zadeh G. MRI biomarkers identify the differential response of glioblastoma multiforme to anti-angiogenic therapy. Neuro Oncol. 2014 Jun;16(6):868-79.

Khan OH, Krischek B, Holliman D, Klironomos G, Kucharczyk W, Vescan A, Gentili F, Zadeh G. Pure endoscopic expanded endonasal approach for olfactory groove and tuberculum sellae meningiomas. J Clin Neurosci. 2014 Jun;21(6):927-33.

Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL, Consortium M, Abeyruwan SW, Beattie MS, Bethea J, Bradke F, Bresnahan JC, Bunge MB, Callahan A, David S, Dunlop SA, Fawcett J, Fehlings M, Fischer I, Giger RJ, Goshima Y, Grimpe B, Hagg T, Hall ED, Harrison BJ, Harvey AR, He C, He Z, Hirata T, Hoke A, Hulsebosch CE, Hurtado A, Jain A, Kadoya K, Kamiguchi H, Kengaku M, Kocsis JD Ph D, Kwon BK, Lee JK, Liebl DJ PhD, Liu SJ, Lowery LA, Mandrekar-Colucci S, Martin JH, Mason CA, McTigue DM, Mokarram N, Moon LD, Muller HW, Nakamura T, Namba T, Nishibe M, Oinuma I, Oudega M, Pleasure DE, Raisman G, Rasband MN, Reier PJ, Santiago-Medina M, Schwab JM, Schwab ME, Shinmyo Y, Silver J, Smith GM, So KF, Sofroniew MV Md PhD, Strittmatter SM, Tuszynski MH, Twiss JL, Visser U, Watkins TA, Wu W, Yoon SO, Yuzaki M, Zheng B, Zhou F, Zou Y. Minimum Information About a Spinal Cord Injury Experiment (MIASCI) - a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 2014 May 28.

Macdonald RL. Editorial: See one, simulate fifty, then do one? J Neurosurg. 2014 Jun 20:1-2.

Moxon-Emre I, Bouffet E, Taylor MD, Laperriere N, Scantlebury N, Law N, Spiegler BJ, Malkin D, Janzen L, Mabbott D. Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma. J Clin Oncol. 2014 Jun 10;32(17):1760-8.

Nishimura Y, Natsume A, Ginsberg HJ. Spinal dural arteriovenous fistula associated with L-4 isthmic spondylolisthesis. J Neurosurg Spine. 2014 Jun;20(6):670-4.

Ravishankar N, Bernstein M. Religion Benefiting Brain Tumour Patients: A Qualitative Study. J Relig Health. 2014 Jun 7.

Samuel N, Remke M, Rutka JT, Raught B, Malkin D. Proteomic analyses of CSF aimed at biomarker development for pediatric brain tumors. J Neurooncol. 2014 Jun;118(2):225-38.

Tzekou A, Fehlings MG. Treatment of spinal cord injury with intravenous immunoglobulin G: Preliminary evidence and future perspectives. J Clin Immunol. 2014 Jul;34 (Suppl 1):S132-S138.

Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Taylor MD, Dirks PB. Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma. Cancer Cell. 2014 Jun 17.

Whitehead WE, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Browd S, Limbrick D, Rozzelle C, Tamber MS, Simon TD, Shannon CN, Holubkov R, Oakes WJ, Luerssen TG, Walker ML, Drake JM, Kestle JR; for the Hydrocephalus Clinical Research Network. Factors associated with ventricular catheter movement and inaccurate catheter location: post hoc analysis of the Hydrocephalus Clinical Research Network Ultrasound-Guided Shunt Placement study. 2014 Jun 13:1-6.

Zadeh G, Aldape K. ACVR1 mutations and the genomic landscape of pediatric diffuse glioma. Nat Genet. 2014 May;46(5):421-2.

VISITING PROFESSORSHIPS – JUNE 2014

Soha Al-Omar (supervisor: Andres Lozano) was an Invited Speaker at the Canadian Neurological Sciences Federation Meeting. “Supraspinal Changes and Functional Neuroimaging of Neuropathic Pain.” Banff, Alberta. June 3-6, 2014.

Leo da Costa was an Invited Speaker at the Innovation and TBI conference. “Mild Head injury and normal imaging: are we seeing it right?” Toronto, Ontario. June 12, 2014.

Leo da Costa delivered one of the CNSS Chair’s Select Abstracts at the CNSF: “Correlation of concussion symptoms and BOLD MRI CO2 challenge.” Banff, Alberta. June 3-6, 2014.

Michael Cusimano was an Invited Lecturer at the 49th Canadian Neurological Sciences Federation Congress. 1.“The impact of bodychecking rule changes on concussion rates from youth to the national hockey league” 2. "Normal Pressure Hydrocephalus". Banff, Alberta. June 3-6, 2014.

Karen Davis chaired a workshop at the 20th Annual Meeting of the Organization for Human Brain Mapping. “A Brave New World? Ethical considerations for individual assessments.” Hamburg, Germany. June 2014.

Karen Davis was a Guest Speaker at the 20th Annual Meeting of the Organization for Human Brain Mapping. “A need for an ethical framework in which to consider biological, neurophysiological and technical factors that impact sensitivity and specificity of neuroimaging in individual subjects.” Hamburg, Germany. June 2014.

Karen Davis was a Guest Speaker at the Keystone Symposia: The Brain: Adaptation and Maladaptation in Chronic Pain. “Pain-Attention Brain Circuitry Phenotypes: Potential for Personalized Therapeutics?” Keystone, Colorado. June 2014.

Mojgan Hodaie was an Invited Moderator at Leksell Gamma Knife Society. New York, NY. May 2014.

Antonio Di Ieva (supervisor: Loch Macdonald) was invited as Faculty Member at the XVII Italian Course of Microneurosurgery, L’Aquila, Italy. June 30-July 2, 2014.

Michael Fehlings was an Invited Speaker at the ACVIM Forum, American College of Veterinary Internal Medicine. 1) “Emerging mechanisms and therapies for acute traumatic spinal cord injury” and 2) “Cervical spondylotic myelopathy: Current pathobiology and therapies.” Nashville, TN. June 4-7, 2014.

Michael Fehlings was an Invited Speaker at NSA Annual Meeting, Neurosurgical Society of America. “Repair and regeneration of the injured spinal cord – From molecule to man.” St. Andrews by the Sea, NB. June 8-11, 2014.

Michael Fehlings was an Invited Speaker at the 39th Annual William S. Keith Professorship in Neurosurgery, Division of Neurosurgery, University Health Network. “Reconstruction of the craniocervical junction and subaxial cervical spine for oncologic indications.” Toronto, ON. June 12-13, 2014.

Michael Fehlings was a Co-Chairman at SpineFEST Visiting Professorship, University of Toronto Spine Program. “Results of ScoliRisk-1 Study.” Toronto, ON. June 23, 2014.

Andres Lozano was an Honored Guest Lecturer at the American Society for Stereotactic and Functional Neurosurgery (ASSFN) 2014 Biennial Meeting. 1) The neurosurgery of memory;” 2) Advances in surgery for movement disorders.” Washington DC. June 2-3, 2014.

Andres Lozano was an Invited Speaker and delivered a public address at the University of Washington’s First Annual NeuroFutures Summit: Closing the Loop between brain mapping, neuromodulation, and brain computer interface. 1) “The brain on circuit training: Finding and fixing misfiring neural circuitry”; 2) “Clinical applications of deep brain stimulation.” Seattle, Washington. June 16-17, 2014.

Andres Lozano delivered the 2014 Innovations Award Lecture at the Canadian College of Neuropsychopharmacology (CCNP) 2014 Annual meeting. “Deep brain stimulation for treatment-resistant depression and Alzheimer’s.” Banff, Alberta. June 20, 2014

Ivan Radovanovic was an Invited Speaker at the 11th European Skull Base Society Congress. 1. “Quantitative assessment of operative fields of minimally invasive approaches to the anterior fossa.” 2. “Special considerations in petrosal dural arteriovenous fistulae assessement and management.” 3. “(Panelist) Vascular Issues in Skull Base Surgery.” Paris, France. June 26-28, 2014.

James Rutka was an Honored Guest at the Rocky Mountain Neurosurgical Society Meeting. 1. “Neurosurgical Leadership: lessons learned.” 2. “Neurosurgical Oncology: What neurosurgeons should know.” Victoria, BC. June 14-18, 2014.

Mohammed Shamji served as an Invited Moderator at the Canadian Neurological Sciences Federation Meeting. “Supraspinal Changes and Functional Neuroimaging of Neuropathic Pain.” June 3, 2014.

Michael Tymianski was an Invited Speaker at the BC Resuscitation Outcomes Consortium Educational Conference. “FRONTIER pre-hospital neuroprotector/placebo: what it is and why it is important.” Vancouver, BC. June 24, 2014.

Gelareh Zadeh was a Course Organizer on Brain Tumor Biology at the Congress of Neurological Sciences Federation. Banff, Alberta. June 2-6, 2014.

Gelareh Zadeh was an Invited Speaker at the Brain Tumor Biology in Congress of Neurological Sciences Federation. “Update of Anti-angiogenesis in Brain Tumors.” Banff, Alberta. June 2-6, 2014.

Gelareh Zadeh was an Invited Speaker at the University of Alberta Neuroscience Rounds. Edmonton. Alberta. June 26-27, 2014.

Gelerah Zadeh presented at Canadian Neuro-oncology Meeting. Halifax, NS. June 2014

Gelareh Zadeh served as Program Chair for the 39th Keith Visiting Professorship at Toronto Western Hospital. June 12-13, 2014.

IN THE MEDIA

Victor Yang’s work on the 7D Surgical Navigation system was features by CBC News online. The piece can be accessed at: http://www.cbc.ca/news/world/scanner-gives-surgeons-real-time- road-map-of-human-body-1.2669579

Charles Tator was featured by The Globe and Mail online in a debate on children and contact sports. The piece can be accessed at: http://www.theglobeandmail.com/globe-debate/should- children-be-banned-from-contact-sports/article19071456/

Andres Lozano’s work on deep brain stimulation for depression, Alzheimer’s disease and epilepsy was featured by the Mayfield Clinic. The piece can be accessed at: http://www.mayfieldclinicblog.com/mayfield-lecturer-dr-andres-lozano-looks-to-dbs-for-new- solutions-to-depression-alzheimers-and-epilepsy/

PDFs OF THE MONTH

Ahmed N, Devitt KS, Keshet I, Spicer J, Imrie K, Feldman L, Cools-Lartigue J, Kayssi A, Lipsman N, Elmi M, Kulkarni AV, Parshuram C, Mainprize T, Warren RJ, Fata P, Gorman MS, Feinberg S, Rutka J. A systematic review of the effects of resident duty hour restrictions in surgery: impact on resident wellness, training, and patient outcomes. Ann Surg. 2014 Jun;259(6):1041-53.

Furlan JC, Chui MH, Croul SE, Kongkham P. Mystery Case: Tanycytic ependymoma of the conus medullaris: A rare cause of low back pain. Neurology. 2014 Jun 17;82(24):e212-3.

Zadeh G, Aldape K. ACVR1 mutations and the genomic landscape of pediatric diffuse glioma. Nat Genet. 2014 May;46(5):421-2.

FACULTY FOCUS

Tom Schweizer, MASc, PhD

Dr. Tom A. Schweizer is an alumnus of the University of Waterloo, where he obtained both an MASc. (2000) and Ph.D. (2004) in Behavioral Neuroscience. Following the completion of his Ph.D. in 2004, Dr. Schweizer undertook a three-year postdoctoral research fellowship in Cognitive Neuroscience with Dr. Donald T. Stuss at the Rotman Research Institute: Baycrest Hospital. During this time, Dr. Schweizer became an Associate Scientist at the Center for Stroke Recovery: Ontario Heart and Stroke Foundation, a position he continues to hold to this day. In 2007, Dr. Schweizer joined the staff of St. Michael’s Hospital as a research scientist working within the Division of Neurosurgery, and, five years later (2012), he was appointed as Director of the Neuroscience Research Program at the same institution. Dr. Schweizer's research has primarily focused on cognitive neuroscience and neuroimaging, especially in terms of how neurocognitive systems dysfunction following brain damage, and how such deficits can be detected using various imaging protocols. In addition to his research pursuits, Dr. Schweizer is an Assistant Professor for the Division of Neurosurgery at the University of Toronto and an adjunct assistant professor for the Faculty of Applied Health Sciences at the University of Waterloo.

Current Appointments

• Assistant Professor (primary appointment), Division of Neurosurgery, Department of Surgery, University of Toronto • Assistant Professor (cross-appointment), Institute of Biomaterials and Biomedical Engineering, University of Toronto • Adjunct Professor, Faculty of Applied Health Sciences, University of Waterloo • Director, Neuroscience Research Program, St. Michael’s Hospital • Scientist, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital • Associate Scientist, Centre for Stroke Recovery, Ontario Heart and Stroke Foundation • Full Member, Institute of Medical Science, University of Toronto Selected Distinctions

• Early Researcher Award, Ontario Ministry of Research and Innovation, 2011-16 • New Investigator Award, Heart and Stroke Foundation of Canada, 2011-16 • The Cynthia Lynn Sherwin Chair of Research Award, The Brain Aneurysm Foundation USA, 2009-10

Selected Publications

• Schweizer TA , Macdonald RL. The Behavioural Consequences of Stroke. Springer, USA. 2014. • Jaja BN, Attalla D, Macdonald RL, Schweizer TA , Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MD, Wong GK. The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage. Neurocrit Care. 2014 May 28. • Hird MA, Vetivelu A, Saposnik G, Schweizer TA. Cognitive, on-road, and simulator-based driving assessment after stroke. The Journal of Stroke and Cerebrovascular Diseases. 2014. In Press. • Ladowski D, Qian W, Kapadia AN, Macdonald RL, Schweizer TA. Effect of aneurysmal subarachnoid hemorrhage on word generation. Behav Neurol. 2014;2014:610868. • Hutchison MG, Schweizer TA Tam F, Graham SJ, Comper P. FMRI and brain activation after sport concussion: a tale of two cases. Front Neurol. 2014 Apr; 14(5):46. • Fischer CE, Schweizer TA. How does speaking another language reduce the risk of dementia? Expert Rev Neurother. 2014 May;14(5):469-71. • Bahrami P, Graham SJ, Grantcharov TP, Cusimano MD, Rotstein OD, Mansur A, Schweizer TA Neuroanatomical correlates of laparoscopic surgery training. Surg Endosc. 2014 Feb 26. • Maher ME, Hutchison M, Cusimano M, Comper P, Schweizer TA. Concussions and heading in soccer: a review of the evidence of incidence, mechanisms, biomarkers and neurocognitive outcomes. Brain Inj. 2014;28(3):271-85. • Al-Khindi T, Macdonald RL, Schweizer TA. Decision-making deficits persist after aneurysmal subarachnoid hemorrhage. Neuropsychology. 2014 Jan;28(1):68-74. • Schweizer TA, Li Z, Fischer C, Alexander M, Smith S, Graham S, Fornazzari L. From the Thalamus with Love: A Rare Window into the Locus of Emotional Synesthesia. Neurology. 2013 Jul 30;81(5):509-10. • Sheldon S, Macdonald RL, Cusimano M, Spears J, Schweizer TA. Long-term consequences of subarachnoid hemorrhage: examining working memory. J Neurol Sci. 2013 Sep 15;332(1- 2):145-7. • Schweizer TA, Kan K, Hung Y, Tam F, Naglie G, Graham SJ. Brain activity during driving with distraction: an immersive fMRI study. Front Hum Neurosci. 2013 Feb 28;7:53. • Schweizer TA, Macdonald RL. Assessing outcome after subarachnoid hemorrhage. Nature Reviews Neurology. 2010 Aug;6(8):427-428. • Cantelmi D, Schweizer TA, Cusimano M. Role of the cerebellum in the neurocognitive sequelae of treatment of tumours of the posterior fossa: An update. Lancet Oncology. 2008; 9(6), 569-576. Selected Professional Appointments

• Co-Chair, Neuroscience Research Rounds, St. Michael’s Hospital (2013 - present). • Member, Executive Committee, Neuroscience and Brain Health Network, University of Toronto (January 2014 - present). • Member, 3T Research MRI Organizational Committee, St. Michael’s Hospital (April 2014 - present). • Member, Publication Committee, Ontario Brain Institute-Ontario Neurodegenerative Disease Research Initiative (April 2014 - present)

UPCOMING NEUROSURGICAL MEETINGS, EVENTS, AND ANNOUNCEMENTS

Academic Career Opportunity

The McGill University Department of Neurology and Neurosurgery and the Department of Neurosurgery of the McGill University Health Centre, Montreal, are currently inviting applications for a full time position as an academic neurovascular surgeon. Please see attached advertisement for full details.

July 2014

Welcome dinner for PGY1 residents in the Department of Surgery. Hosted at the Department Chairman Dr. James Rutka’s home. Sat., Jul. 5, 2014. 6 pm.

Welcome BBQ for incoming Neurosurgery residents and fellows. At the Division Chair Dr. Andres Lozano’s home. Sun., Jul. 6, 2014. More information to follow.

September 2014

American Academy of Neurological Surgery (AAcNS) Annual Meeting. WaterColor Inn and Resort. Santa Rosa Beach, FL. Sep. 16-21, 2014.

October 2014

Congress of Neurological Surgeons (CNS) Annual Meeting. Boston, MA. Oct. 18-22, 2014.

Research Update in Neuroscience for Neurosurgeons (RUNN) Course. Woods Hole, Massachusetts. Oct. 25-Nov. 1, 2014. More information is available at: https://www.societyns.org/runn/index.asp

November 2014

12th Annual Charles Tator-Barbara Turnbull Lectureship Series in Spinal Cord Injury. Keynote Speaker: Dr. Ole Kiehn, Karolinska Institute. More information to follow. Fri., Nov. 7, 2014.

“TB or not to be-spondylodiscitis and beyond.” Visiting Professor Robert Dunn from Capetown, South Africa. Hosted by Sunnybrook Health Sciences Centre. Friday November 21st, 2014. Sunnybrook M6502 Lecture Theatre at 7:30am.

RESIDENTS CORNER

Brain School Schedule & Events - thebrainschool.net

The new schedule will be included in the next issue of Neurosurge.

RESIDENCY PROGRAM COMMITTEE MEETING September 2014 (details t.b.d.)

NEUROSURGERY CABINET MEETING September 2014 (details t.b.d.)