Import Risk Assessment Report by Stephen Cobb
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African and Classical Swine Fever: Similarities, Differences And
Schulz et al. Vet Res (2017) 48:84 DOI 10.1186/s13567-017-0490-x REVIEW Open Access African and classical swine fever: similarities, diferences and epidemiological consequences Katja Schulz1* , Christoph Staubach1 and Sandra Blome2 Abstract For the global pig industry, classical (CSF) and African swine fever (ASF) outbreaks are a constantly feared threat. Except for Sardinia, ASF was eradicated in Europe in the late 1990s, which led to a research focus on CSF because this disease continued to be present. However, ASF remerged in eastern Europe in 2007 and the interest in the disease, its control and epidemiology increased tremendously. The similar names and the same susceptible species suggest a similarity of the two viral diseases, a related biological behaviour and, correspondingly, similar epidemiological features. However, there are several essential diferences between both diseases, which need to be considered for the design of control or preventive measures. In the present review, we aimed to collate diferences and similarities of the two diseases that impact epidemiology and thus the necessary control actions. Our objective was to discuss criti- cally, if and to which extent the current knowledge can be transferred from one disease to the other and where new fndings should lead to a critical review of measures relating to the prevention, control and surveillance of ASF and CSF. Another intention was to identify research gaps, which need to be closed to increase the chances of a successful eradication of ASF and therefore for a decrease -
Teschen Disease (Teschovirus Encephalomyelitis) Eradication in Czechoslovakia: a Historical Report
Historical Report Veterinarni Medicina, 54, 2009 (11): 550–560 Teschen disease (Teschovirus encephalomyelitis) eradication in Czechoslovakia: a historical report V. Kouba* Prague, Czech Republic ABSTRACT: Teschen disease (previously also known as Klobouk’s disease), actually called Teschovirus encepha- lomyelitis, is a virulent fatal viral disease of swine, characterized by severe neurological disorders of encephalomy- elitis. It was initially discovered in the Teschen district of North-Eastern Moravia. During the 1940s and 1950s it caused serious losses to the pig production industry in Europe. The most critical situation at that time, however, was in the former Czechoslovakia. A nationally organized eradication programme started in 1952. That year the reported number of new cases of Teschen disease reached 137 396, i.e., an incidence rate of 2 794 per 100 000 pigs, in 14 801 villages with 65 597 affected farms, i.e., 4.43 affected farms per village and 2.10 diseased pigs per affected farm. The average territorial density of new cases was 1.07 per km2. For etiological diagnosis histological investigation of the central nervous system, isolation of virus and seroneutralization were used. Preventive meas- ures consisted in feeding pigs with sterilized waste food and in ring vaccination. Eradication measures took the form of the timely detection and reporting of new cases, isolating outbreak areas, and the slaughter of intrafocal pigs followed by sanitation measures. Diseased pigs were usually destroyed in rendering facilities. The carcasses of other intrafocal pigs were treated as conditionally comestible, i.e., only after sterilization. During the years 1952–1965 from a reported 537 480 specifically diseased pigs 36 558 died; i.e., Teschen disease mortality rate was 6.80% while other intrafocal pigs (88.12%) were urgently slaughtered. -
AAVLD Plenary Session Saturday, Oct 20, 2007 Ponderosa B
AAVLD Plenary Session Saturday, Oct 20, 2007 Ponderosa B “Past, present and future of veterinary laboratory medicine” Moderator: Grant Maxie 07:30 AM Welcome - Grant Maxie, President-Elect, AAVLD David Steffen, Vice-President, AAVLD 07:35 AM The evolution of the AAVLD - Robert Crandell, Larry Morehouse, Vaughn Seaton 08:15 AM Veterinary diagnostic toxicology: from spots to peaks to fragments and beyond (or why does diagnostic toxicology cause economic heartburn for laboratory directors?) - Robert Poppenga, Mike Filigenzi, Elizabeth Tor, Linda Aston, Larry Melton, Birgit Puschner 08:45 AM Microspheres and the evolution of testing platforms - Susan Wong 09:15 AM BREAK 09:45 AM A production management (client’s) perspective on diagnostics - Dale Grotelueschen 10:15 AM AAVLD survey of pet food-induced nephrotoxicity in North America, April to June, 2007 - Wilson Rumbeiha, Dalen Agnew, Grant Maxie, Michael Scott, Brent Hoff, Barbara Powers 10:45 AM Ecosystem health, agriculture, and diagnostic laboratories: challenges and opportunities - Thomas Besser 11:15 AM House of Delegates Virology Scientific Session Saturday, October 20, 2007 Bonanza A Moderators: Kyoung-Jin Yoon, Kristy Lynn Pabilonia 1:00 PM Further improvement and validation of MagMAX-96 AI/ND viral RNA isolation kit for efficient removal of RT-PCR inhibitors from cloacal swabs and tissues for rapid diagnosis of avian influenza virus by real-time reverse transcription PCR - Amaresh Das, Erica Spackman, Mary J. Pantin-Jackwood, David E. Swayne, David Suarez 1:15 PM Development of -
A Field and Laboratory Investigation of Viral Diseases of Swine in the Republic of Haiti
Original research Peer reviewed A field and laboratory investigation of viral diseases of swine in the Republic of Haiti Rodney Jacques-Simon, DVM; Max Millien, DVM; J. Keith Flanagan, DVM; John Shaw, PhD; Paula Morales, MS; Julio Pinto, DVM, PhD; David Pyburn, DVM; Wendy Gonzalez, DVM; Angel Ventura, DVM; Thierry Lefrancois, DVM, PhD; Jennifer Pradel, DVM, MS, PhD; Sabrina Swenson, DVM, PhD; Melinda Jenkins-Moore; Dawn Toms; Matthew Erdman, DVM, PhD; Linda Cox, MS; Alexa J. Bracht; Andrew Fabian; Fawzi M. Mohamed, BVSc, MS, PhD; Karen Moran; Emily O’Hearn; Consuelo Carrillo, DVM, PhD; Gregory Mayr, PhD; William White, BVSc, MPH; Samia Metwally, DVM, PhD; Michael T. McIntosh, PhD; Mingyi Deng, DVM, MS, PhD Summary porcine teschovirus type 1 (PTV-1) and por- PRRSV, and SIV, are present in the Haitian Objective: To confirm the prevalence of cine circovirus type 2 (PCV-2), respectively. swine population. Additionally, 7.3%, 11.9%, and 22.0% of teschovirus encephalomyelitis in multiple Implications: Due to the close proximity sera were positive for antibodies to porcine regions in Haiti and to identify other viral of the Hispaniola to Puerto Rico, a territory reproductive and respiratory syndrome virus agents present in the swine population. of the United States, and the large number (PRRSV) and swine influenza virus (SIV) of direct flights from the Hispaniola to the Materials and methods: A field investiga- H3N2 and H1N1, respectively. Among the United States, the risk of introducing the tion was conducted on 35 swine premises 54 sera positive for antibodies to PTV-1, viral diseases mentioned in this paper into located in 10 regions. -
Classical Swine Fever Standard Operating Procedures: 1. Overview of Etiology and Ecology
CLASSICAL SWINE FEVER STANDARD OPERATING PROCEDURES: 1. OVERVIEW OF ETIOLOGY AND ECOLOGY OCTOBER 2016 File name: CSF_FAD_PReP_E&E_October2016 Lead section: Preparedness and Incident Coordination Version number: 4.0 Effective date: October 2016 Review date: October 2019 The Foreign Animal Disease Preparedness and Response Plan (FAD PReP) Standard Operating Procedures (SOPs) provide operational guidance for responding to an animal health emergency in the United States. These draft SOPs are under ongoing review. This document was last updated in October 2016. Please send questions or comments to: National Preparedness and Incident Coordination Center Veterinary Services Animal and Plant Health Inspection Service U.S. Department of Agriculture 4700 River Road, Unit 41 Riverdale, Maryland 20737 Fax: (301) 734-7817 E-mail: [email protected] While best efforts have been used in developing and preparing the FAD PReP SOPs, the U.S. Government, U.S. Department of Agriculture (USDA), and the Animal and Plant Health Inspection Service and other parties, such as employees and contractors contributing to this document, neither warrant nor assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information or procedure disclosed. The primary purpose of these FAD PReP SOPs is to provide operational guidance to those government officials responding to a foreign animal disease outbreak. It is only posted for public access as a reference. The FAD PReP SOPs may refer to links to various other Federal and State agencies and private organizations. These links are maintained solely for the user’s information and convenience. If you link to such site, please be aware that you are then subject to the policies of that site. -
Emerging Porcine Adenovirus Padv-SVN1 and Other Enteric Viruses in Samples of Industrialized Meat By-Products
Ciência Rural,Emerging Santa Porcine Maria, adenovirus v.50:12, PAdV-SVN1 e20180931, and other2020 enteric viruses in samples of http://doi.org/10.1590/0103-8478cr20180931industrialized meat by-products. 1 ISSNe 1678-4596 MICROBIOLOGY Emerging Porcine adenovirus PAdV-SVN1 and other enteric viruses in samples of industrialized meat by-products Fernanda Gil de Souza1* Artur Fogaça Lima1 Viviane Girardi1 Thalles Guillem Machado1 Victória Brandalise1 Micheli Filippi1 Andréia Henzel1 Paula Rodrigues de Almeida1 Caroline Rigotto1 Fernando Rosado Spilki1 1Laboratório de Microbiologia Molecular, Instituto de Ciências da Saúde, Universidade Feevale, 93352-000, Novo Hamburgo, RS, Brasil. E-mail: [email protected]. *Corresponding author. ABSTRACT: Foodborne diseases are often related to consumption of contaminated food or water. Viral agents are important sources of contamination and frequently reported in food of animal origin. The goal of this study was to detect emerging enteric viruses in samples of industrialized foods of animal origin collected in establishments from southern of Brazil. In the analyzed samples, no Hepatitis E virus (HEV) genome was detected. However, 21.8% (21/96) of the samples were positive for Rotavirus (RVA) and 61.4% (59/96) for Adenovirus (AdV), including Human adenovirus-C (HAdV-C), Porcine adenovirus-3 (PAdV-3) and new type of porcine adenovirus PAdV-SVN1. In the present research, PAdV-SVN1 was detected in foods for the first time. The presence of these viruses may be related to poor hygiene in sites of food preparation, production or during handling. Key words: PAdV-SVN1, RV, gastroenteritis. Detecção de adenovírus suíno PAdV-SVN1 emergente e outros vírus entéricos em amostras de subprodutos de carne industrializados RESUMO: As doenças transmitidas por alimentos são frequentemente descritas e relacionadas ao consumo de alimentos ou água contaminados, sendo alguns agentes virais importantes fontes de contaminação e frequentemente encontrados em alimentos de origem animal. -
Arenaviridae Astroviridae Filoviridae Flaviviridae Hantaviridae
Hantaviridae 0.7 Filoviridae 0.6 Picornaviridae 0.3 Wenling red spikefish hantavirus Rhinovirus C Ahab virus * Possum enterovirus * Aronnax virus * * Wenling minipizza batfish hantavirus Wenling filefish filovirus Norway rat hunnivirus * Wenling yellow goosefish hantavirus Starbuck virus * * Porcine teschovirus European mole nova virus Human Marburg marburgvirus Mosavirus Asturias virus * * * Tortoise picornavirus Egyptian fruit bat Marburg marburgvirus Banded bullfrog picornavirus * Spanish mole uluguru virus Human Sudan ebolavirus * Black spectacled toad picornavirus * Kilimanjaro virus * * * Crab-eating macaque reston ebolavirus Equine rhinitis A virus Imjin virus * Foot and mouth disease virus Dode virus * Angolan free-tailed bat bombali ebolavirus * * Human cosavirus E Seoul orthohantavirus Little free-tailed bat bombali ebolavirus * African bat icavirus A Tigray hantavirus Human Zaire ebolavirus * Saffold virus * Human choclo virus *Little collared fruit bat ebolavirus Peleg virus * Eastern red scorpionfish picornavirus * Reed vole hantavirus Human bundibugyo ebolavirus * * Isla vista hantavirus * Seal picornavirus Human Tai forest ebolavirus Chicken orivirus Paramyxoviridae 0.4 * Duck picornavirus Hepadnaviridae 0.4 Bildad virus Ned virus Tiger rockfish hepatitis B virus Western African lungfish picornavirus * Pacific spadenose shark paramyxovirus * European eel hepatitis B virus Bluegill picornavirus Nemo virus * Carp picornavirus * African cichlid hepatitis B virus Triplecross lizardfish paramyxovirus * * Fathead minnow picornavirus -
Immunopathogenesis of Postnatal Persistent Infection Generated by Classical Swine Fever Virus and Its Implication in the Superinfection Exclusion Phenomenon
ADVERTIMENT. Lʼaccés als continguts dʼaquesta tesi queda condicionat a lʼacceptació de les condicions dʼús establertes per la següent llicència Creative Commons: http://cat.creativecommons.org/?page_id=184 ADVERTENCIA. El acceso a los contenidos de esta tesis queda condicionado a la aceptación de las condiciones de uso establecidas por la siguiente licencia Creative Commons: http://es.creativecommons.org/blog/licencias/ WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en Immunopathogenesis of postnatal persistent infection generated by classical swine fever virus and its implication in the superinfection exclusion phenomenon Sara Muñoz González PhD Thesis Bellaterra, 2017 Immunopathogenesis of postnatal persistent infection generated by classical swine fever virus and its implication in the superinfection exclusion phenomenon Tesis doctoral presentada por Sara Muñoz González para acceder al grado de doctor en el marco del programa de Doctorado en Medicina y Sanidad Animal de la Facultat de Veterinaria de la Universitat Autònoma de Barcelona, bajo la dirección de la Dra. Llilianne Ganges Espinosa y del Dr. Mariano Domingo Álvarez. Bellaterra, 2017 This work has been financially supported by grant AGL2012-38343 from Spanish government Sara Muñoz-González received predoctoral fellowship FI-DGR 2014 from AGAUR, Generalitat de Catalunya. La Dra Llilianne Ganges Espinosa, investigadora del -
Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis
Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis, Weakness, and Paralysis among Weaned Pigs, Hungary Ákos Boros, Mihály Albert, Péter Pankovics, Hunor Bíró, Patricia A. Pesavento, Tung Gia Phan, Eric Delwart, Gábor Reuter A large, highly prolific swine farm in Hungary had a 2-year nervous system (CNS) involvement were reported re- history of neurologic disease among newly weaned (25- to cently in mink, human, bovine, ovine, and swine hosts 35-day-old) pigs, with clinical signs of posterior paraplegia (the latter in certain cases of AII type congenital tremors) and a high mortality rate. Affected pigs that were necropsied (5,6,12–14). Most neuroinvasive astroviruses belong to had encephalomyelitis and neural necrosis. Porcine astrovi- the Virginia/Human-Mink-Ovine (VA/HMO) phyloge- rus type 3 was identified by reverse transcription PCR and in netic clade and cluster with enteric astroviruses identi- situ hybridization in brain and spinal cord samples in 6 ani- mals from this farm. Among tissues tested by quantitative RT- fied from asymptomatic or diarrheic humans and animals PCR, the highest viral loads were detected in brain stem and (15,16). Recent research shows that pigs harbor one of the spinal cord. Similar porcine astrovirus type 3 was also detect- highest astrovirus diversities among mammals examined ed in archived brain and spinal cord samples from another 2 (3,15,20). Porcine astroviruses (PoAstVs) were identified geographically distant farms. Viral RNA was predominantly mainly from diarrheic fecal specimens, less commonly restricted to neurons, particularly in the brain stem, cerebel- from respiratory specimens, although the etiologic role of lum (Purkinje cells), and cervical spinal cord. -
Effectors of Mycoplasmal Virulence 1 2 Virulence Effectors of Pathogenic Mycoplasmas 3 4 Meghan A. May1 And
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 27 September 2018 doi:10.20944/preprints201809.0533.v1 1 Running title: Effectors of mycoplasmal virulence 2 3 Virulence Effectors of Pathogenic Mycoplasmas 4 5 Meghan A. May1 and Daniel R. Brown2 6 7 1Department of Biomedical Sciences, College of Osteopathic Medicine, University of New 8 England, Biddeford ME, USA; 2Department of Infectious Diseases and Immunology, College 9 of Veterinary Medicine, University of Florida, Gainesville FL, USA 10 11 Corresponding author: 12 Daniel R. Brown 13 Department of Infectious Diseases and Immunology, College of Veterinary Medicine, 14 University of Florida, Gainesville FL, USA 15 Tel: +1 352 294 4004 16 Email: [email protected] 1 © 2018 by the author(s). Distributed under a Creative Commons CC BY license. Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 27 September 2018 doi:10.20944/preprints201809.0533.v1 17 Abstract 18 Members of the genus Mycoplasma and related organisms impose a substantial burden of 19 infectious diseases on humans and animals, but the last comprehensive review of 20 mycoplasmal pathogenicity was published 20 years ago. Post-genomic analyses have now 21 begun to support the discovery and detailed molecular biological characterization of a 22 number of specific mycoplasmal virulence factors. This review covers three categories of 23 defined mycoplasmal virulence effectors: 1) specific macromolecules including the 24 superantigen MAM, the ADP-ribosylating CARDS toxin, sialidase, cytotoxic nucleases, cell- 25 activating diacylated lipopeptides, and phosphocholine-containing glycoglycerolipids; 2) 26 the small molecule effectors hydrogen peroxide, hydrogen sulfide, and ammonia; and 3) 27 several putative mycoplasmal orthologs of virulence effectors documented in other 28 bacteria. -
Preliminary Investigations Into Ostrich Mycoplasmas : Indentification Of
PRELIMINARY INVESTIGATIONS INTO OSTRICH MYCOPLASMAS: IDENTIFICATION OF VACCINE CANDIDATE GENES AND IMMUNITY ELICITED BY POULTRY MYCOPLASMA VACCINES Elizabeth Frances van der Merwe Thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at the University of Stellenbosch. Study leader: Prof D.U. Bellstedt December 2006 Declaration I, the undersigned, hereby declare that the work contained in this thesis is my own original work and has not previously in its entirety or in part been submitted at any university for a degree. Signature: Date: i Summary Ostrich farming is of significant economical importance in South Africa. Three ostrich mycoplasmas, Ms01, Ms02 and Ms03 have been identified previously, and were provisionally named ‘Mycoplasma struthiolus’ (Ms) after their host Struthio camelus. Ostrich mycoplasmas are the major causative organisms of respiratory diseases, and they cause stock losses, reduced production and hatchability, and downgrading of carcasses and therefore lead to large economic losses to the industry. In order to be pathogenic to their host, they need to attach through an attachment organelle, the so-called tip structure. This structure has been identified in the poultry mycoplasma, M. gallisepticum, and is made up of the adhesin GapA and adhesin-related CrmA. Currently, no ostrich mycoplasma vaccine is commercially available and for this reason the need to develop one has arisen. Therefore the first part of this study was dedicated to the identification and isolation of vaccine candidate genes in the three ostrich mycoplasmas. Four primer approaches for polymerase chain reactions (PCR’s), cloning and sequencing, were used for the identification of adhesin or adhesin-related genes from Ms01, Ms02 and Ms03. -
Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China During 2016–2018
viruses Article Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China during 2016–2018 Madiha Fatima 1,† , Yuzi Luo 1,†, Li Zhang 1, Peng-Ying Wang 2, Hao Song 1, Yanhui Fu 1, Yongfeng Li 1, Yuan Sun 1, Su Li 1, Yun-Juan Bao 2,* and Hua-Ji Qiu 1,* 1 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Road, Harbin 150069, China; [email protected] (M.F.); [email protected] (Y.L.); [email protected] (L.Z.); [email protected] (H.S.); [email protected] (Y.F.); [email protected] (Y.L.); [email protected] (Y.S.); [email protected] (S.L.) 2 State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430062, China; [email protected] * Correspondence: [email protected] (Y.-J.B.); [email protected] (H.-J.Q.); Tel.: +86-18630800480 (Y.-J.B.); +86-13019011305 (H.-J.Q.) † These authors contributed equally to this work. Abstract: Classical swine fever (CSF) is a highly contagious disease of swine caused by classical swine fever virus (CSFV). For decades the disease has been controlled in China by a modified live vaccine (C-strain) of genotype 1. The emergent genotype 2 strains have become predominant in China in the past years that are genetically distant from the vaccine strain. Here, we aimed to evaluate the current Citation: Fatima, M.; Luo, Y.; Zhang, infectious status of CSF, and for this purpose 24 isolates of CSFV were identified from different L.; Wang, P.-Y.; Song, H.; Fu, Y.; Li, Y.; areas of China during 2016–2018.