Spring 2011 Van Amstel S

Recent Presentations In this Issue Bartges J. Pedigo A Odoi A. Vol. 6, Issue 1 Small animal case studies. , Aldrich T, Neighborhood Veterinary Conference; January 2011; Spring 2011 Van Amstel S. p1–UTCVM Research Office changes, OIT software; p2–Kalck, Newkirk, & Whitlock ITC grants, publications; Presentation at: UTCVM Annual disparities in stroke and heart attack Orlando, FL. Callens A. p3– PubMed Central, CEMPH Research Symposium, open access support, externally funded awards; p4– Conference; February 2011; Knoxville, TN. mortality in East Tennessee. Poster Medical conditions of presented at: Cardiovascular Disease presentations Getting on the right tract: pet pigs; Surgical conditions of pet pigs; Changes for the UTCVM Office of Research by Dr. Michael McEntee Epidemiology and Prevention 2011 Lameness in commercial and pet pigs. Urinary tract issues. Presentation at: Scientific Sessions; March 24, 2011; UTCVM Annual Conference; February Pedigo A Odoi A Invited presentations at: North American Craig L Atlanta, GA. Veterinary Conference; January 16, 2011; 2011; Knoxville, TN. Van Amstel S, , Aldrich T, . Place matters! Orlando, FL. he Greek philosopher Heraclitus said the only thing constant is change. As with everything in life, . . Synovial tumours in dogs. Disparities in ambulance response and this idea holds true for the UTCVM Office of Research and Graduate Studies, as well. In February, Presentation at: New Zealand Society Shearer JK, Cooper transport times for stroke and heart VL Clinical signs, histopathology and Dr. Leon Potgieter, Interim Associate Dean, retired and transferred his interim title onto Dr. Michael for Veterinary & Comparative Pathology attack patients in East Tennessee. Oral McEntee until a search for a non-interim replacement is complete. Annual Conference; February 13, 2011; treatment of atypical digital dermatitis Davis J. presentation at: Cardiovascular Disease The college has set research/discovery and clinical service as priorities in strategic planning for Palmerston North, New Zealand. in cattle. Presented at: International T Epidemiology and Prevention 2011 Ruminant Lameness Symposium; March 3, the next 5 years. With discovery, it is important to examine our strengths and build on them, recognizing Dermatology techniques and Scientific Sessions; March 25, 2011; Van Amstel S, Pluchino L, Wang H-CR. 2011; Rotorua, New Zealand. that we lack the infrastructure and critical mass of larger institutions. While we do have productive, special tips lab. Presentation at: UTCVM Atlanta, GA. well-funded research programs in basic biomedical, translational, and clinical medicine, there has been Annual Conference; February 2011; Shearer JK. Pathogenesis Frank L. The role of relatively little collaboration between groups to provide the synergy necessary to achieve the broader Knoxville, TN. and differentiation of toe lesions in cattle. HSD11B2 in the regulation of cellular Presented at: International Ruminant scope that might attract funding for program or training grants, or significant foundational support. Alopecia–Is it hormonal?; The itchy properties. Poster presented at: The Lameness Symposium; March 3, 2011; As we go forward in building our research enterprise, it will be important to consider how to Wang H-CR cat; Managing canine otitis. Presentations University of Tennessee/Oak Ridge Rotorua, New Zealand. buttress and expand our current areas of strength with strategic hires and development of collaborations at: UTCVM Annual Conference; February National Laboratory Graduate School of Miller DL. across campuses and the state. This will not happen overnight and will require a college-wide discussion 2011; Knoxville, TN. Genome Science & Technology Annual . In vitro progressive cellular Retreat; March 4, 2011; Knoxville, TN. carcinogenesis model. Invited presentation about where our strengths reside and where we might consider focusing in the longer term. Should Gray MJ, Duffus ALJ, Ecology Rathore K, Wang H-CR Abstract 26. at: NIMBioS Investigative Workshop – Solid we direct efforts toward major funding agencies (NIH, USDA, DOD), our clinical strengths, and/or what and pathology of ranaviruses. Workshop Tumor Modeling; January 2011; Knoxville, would arguably benefit Tennesseeans and their agriculture? What do we have now in people, facilities, presented at: Southeastern Partners in . Green tea Wells J. TN. or location that gives us an edge in addressing problems that are backed by funding sources? Amphibian and Reptile Conservation catechins at non-cytotoxic levels suppress Annual Meeting; February 2011; Louisville, cellular carcinogenesis induced by Acute renal failure. Presentation Just as important is to ensure veterinarians have an increasing role in biomedical research, Hecht S. at: UTCVM Annual Conference; February not only for the health of our profession, but because DVMs can contribute a unique perspective and MS. environmental carcinogens. Poster Whittemore J 2011; Knoxville, TN. knowledge-base highly relevant to a wide range of topics from human and animal Small animal applications of presented at: The University of Tennessee/ health to the environment. How do we in the UTCVM help increase the number magnetic resonance imaging–Update. Oak Ridge National Laboratory Graduate . Presumptive steroid Presentation at: UTCVM Annual School of Genome Science & Technology hepatotoxicity in dogs and cats. Presented of DVMs actively engaged in scientific discovery and contributing to our global Kennedy M. Annual Retreat; March 4, 2011; Knoxville, health? Conference; February 2011; Knoxville, TN. Schumacher J. at: Comparative Gastroenterology Society TN. Abstract 27. Annual Conference; March 2011; Manuel We have a small research footprint compared to many other colleges of Immunology. Lectures Wilson M Antonio, Costa Rica. veterinary medicine, and we lack the engine of a robust local biomedical research presented at: Western States Veterinary There is a snake in room Conference; February 24, 2011; Las Vegas, #!#!: Handling and clinical procedures for . Small animal oncology: The environment often provided by larger medical schools; so we need to build a LeBlanc A NV. snakes; Hypothermia is not appropriate veterinary technician’s role. Presentation strength internally (difficult to imagine more than one or two overlapping) and/

reptile anesthesia: Reptile anesthesia and at: UTCVM Annual Conference; February C oor m develop p a s stronger s i o n collaborative ties with our neighbors, which will happen . PET/CT in veterinary oncology: Wyatt N analgesia; A review of selected surgical 2011; Knoxville, TN. only when they understand what we have to offer. In summary, we can do a Evidence for clinical use. Presentation cases in reptiles; Ultrasound and CT– at: Northern California Oncology Forum; . Small animal behavior rounds– lot to increase research productivity and graduate training within the CVM, and Miller DL Practical uses for the reptile patient; Lions, How the veterinary technician can be the introduction of a fresh perspective in the form of a new Associate Dean for February 4, 2011; Redwood City, CA. tigers and bears – Oh my! Large carnivore involved. Lab presented at: UTCVM Annual Research will no doubt help realign our efforts and strengthen our programs. , Gray MJ. Pathological changes sanctuary medicine; Getting hands-on: Conference; February 2011; Knoxville, TN. OIT’s Analysis System Offers Variety of Research Software for associated with ranaviral disease. Invited Restraint and immobilization of wild presentation at: 36th Annual Eastern Fish animals in your clinic. Presented at: North Little to Nothing Health Workshop; March 28–April 1, 2011; American Veterinary Conference; January Miller DL, Tobias K Mt. Pleasant, SC. 2011; Orlando, Florida. Duffus ALJ, Gray MJ. Disease . Small animal soft tissue he Office of Information Technology (OIT) at UT offers the analysis.utk.edu system, which surveillance and biosecurity techniques. surgery. Lecture presented at: Colonial allows users to run both quantitative and qualitative research analysis software as if it were Workshop presented at: Southeastern Veterinary Conference; December 2010; Tobias K installed on their own computer. The software runs on a server and displays an image of itself on Partners in Amphibian and Reptile Williamsburg, VA. the user’s computer. With it, users may open and save files on their own computer’s disk drive and Conservation Annual Meeting; February . Small animal soft tissue surgery. print to their own printer, and it works from any Windows, Macintosh, Linux, or Solaris computer. 2011; Louisville, MS. Lecture presented at: North American T Students may access these tools using their Net ID and password. Faculty and staff must purchase a client access license through the Bookstore Technology Center for a one-time fee of $17. Software available on Analysis includes Amos, ATLAS.ti; Clementine, EQS; ImageJ, JMP, Maple,

K n o w l e dMathematica, g e MATLAB, Mestrenova, Mplus, N6/NUD*IST, Origin, QDA Miner, R, SAS, SAS Enterprise Guide, SAS [email protected] Miner, SAS Text Miner, Scientific Notebook, SigmaPlot, SigmaScan, Simstat, Discovery is published four times each year by the UTCVM Office of Research and Graduate Programs. Comments and suggestions may SPSS, Stata, and SUDAAN. be forwarded to the office in care of Misty Bailey: [email protected] or 865-974-7446. Photos copyright University ofTennessee. E-mail if problems are encountered in accessing the system. UT is an EEO/AA/Title IX/Section 504/ADA/ADEA Institution Research at the University of Tennessee College of Veterinary Medicine PA# E181703-00-001-10 Kalck, Newkirk, Whitlock Recipients of ITC Faculty First Grants Discovery: Research at the University of Tennessee College of Veterinary Medicine (2011) 6.1 3

he Innovative Technology Consulting division at UT accepts Newkirk’s award will allow easy Web-based access to Research Resource Spotlight proposals each year forDr. projects Karen involving Kalck technologyDr. Brian in gross pathology images for faculty to use in teaching. A self-quiz Whitlockteaching. Two recipients of this year’sDr. Kimgrants Newkirk are Large Animal feature will allow veterinary students to enhance their classroom PMID to PMCID Converter Clinical Sciences faculty and learning of pathology. Her project title is “Development of a Web- ll NIH-funded research articles are now required to be sults for up T and Pathobiology faculty . based searchable archive for pathology images.” Adeposited into PubMed Central. Most journals pro- to 2,000 PMIDs in either PMCIDs or NIHMS IDs, if they Kalck’s project, entitled “Choose your own adventure Whitlock's plan, "Mobile teaching and learning module vide this service free to authors; others require the authors exist. PubMed users may perform a search of their pub- in equine medicine,” will allow veterinary students to for VM893 (Field Services)," is to develop a clinical, case-based to pay if they wish to use the service; and still others re- lished articles and produce a PMID list to copy and paste encounter cases through Web-based modules developed from learning module with interactive comprehension assessments quire the authors to submit the articles to PubMed Central to the converter by choosing “PMID List” from the “For- previous hospital cases. The format will include rewards and that can be used in a mobile (truck) environment like the one themselves. mat” options in the “Display Settings” drop-down arrow consequences for procedure, diagnosis, and treatment choices, in field services, when students spend a considerable amount of These PubMed Central identification numbers located at the top of the search results page. time driving from farm to farm. The assessment portion of the and the program will increase student opportunities to learn  (PMCIDs) must then be included in NIH grant applica- The PMID: PMCID Converter is located at http:// about equine medicine at a time when economic uncertainty is project will allow Whitlock to evaluate student comprehension  slowing the incoming caseload. in the field and in theJ classroom, as well. tions and progress reports when an author references his or www.ncbi.nlm.nih.gov/sites/pmctopmid. Recent Publications her own NIH-funded publications, both in the references Chromatogr B Depositing a Manuscript performance liquid chromatography. to microcystin-LREnviron and Sci microcystis Technol section and in the biosketch. Anis E, O’Neill S, Newkirk K, Brahmbhatt Flatland B, Fry MM, LeBlanc CJ, Rohrbach 2011;879:205–208. reveals endocrine disrupting effects The National Center for Biotechnology Informa- into PubMed Central R, Abd-Eldaim M, Frank L, Kania S. BW. of cyanobacteria. Hands-on Workshop Souza MJ, Cox S. tion (NCBI) offers a PubMed ID (PMID) to PMCID con- 2011;45:1962–1969. Leukocyte and platelet changes Vet Clin N Am Exot Anim Pract verter for easier reporting. This converter will return re- Thursday, April 14, 1–2 pm Molecular characterization of human and following Res low-dose Vet Sci lipopolysaccharide Tramadol use in zoologic A335 Vet Med Bldg feline papillomavirusAm L1 genesJ Vet fromRes cats administration in five dogs. medicine. Led by Misty Bailey Souza MJ, Martin-Jimenez T, Jones MP, with premalignant and malignant 2011;90:89–94. 2011;14:117–130. Cox SK CEMPH Research Symposium June 20 & 21 epithelial lesions. [A summary of this article Hecht S Buteo jamaicensis J 2010;71:1457–1461. appeared in VerticalNews Vet Pharmacol. Pharmacokinetics Ther of oral tramadol his year’s Comparative & Experimental Medicine and Public Health Atkins RM, , Westermeyer Veterinary. Available at: in red-tailed hawks ( ). Research Symposium will take place on June 20 & 21 in the Veterinary Open Access Publishing Tobias KM T HD, McLean NJ. WhatJ Am Vetis your Med http://veterinary.verticalnews. 2011;34:86–88. com/articles/4877942.html. Clinical Veterinary Advisor: Dogs Medicine Building. Support Available Assocdiagnosis? – Zygomatic salivary Haines D, Newkirk K. mucocele in a dog. Accessed on March 17, 2011.] and Cats . Nasopharyngeal polyps. In: Once again, we expect around 100 new investigator presentations re- Baek SJ, Whitlock NC. 2010;237:1375–1376. Cote E, ed. lated to human and animal health, with presenters from four different UT cam- . 2nd ed. St. Louis, MO: Mosby puses. The format for these talks will be 10-minute Analyzing histologyJ Biocommun images Tobias KM. ublishing in an open-access (2011) Elsevier;2011:751–752. oral presentations, followed by 5 minutes for ques- MolecularEvidence-based targets of Anticancer resveratrol Herbal with Photoshop Extended Clinical Veterinary Advisor: Dogs journal is easier than ever thanks CS3 and CS4. . Hypoplastic trachea. In: Cote tions. Medicinein carcinogenesis. In: Cho WCS, Hecht S. and Cats to the UTK Office of Research and ed. 2010;36:E52–E56. E, ed. Of the four featured speakers, we are espe- University Libraries. They are . Dordrecht, Netherlands: . 2nd ed. St. Louis, MO: Mosby cially excited to welcome Dr. Franziska Grieder, Di- continuing to offer up to $3,000 per Hecht S, MRI diagnosis: Ventral intraspinal Tobias KM. Springer;313–340. Elsevier;2011:581–582. Particle toward article-processing fees Mankin JM, Novak JM, Donnell RL. cyst in a dog. American College of Veterinary Clinical Veterinary rector of the Division of Comparative Medicine at Baron ML, Westermeyer HD, Radiology CT/MRI Society Case of the Advisor: Dogs andForeign Cats body, respiratory the National Center for Research Resources (NIH). for open-access publishing. Blastomyces dermatitidis month-February 2011. Available at: http:// tract. In: Cote E, ed. Dr. Grieder will present “One health, one medicine: Applications are funded on mirc.veterinaryradiology.net/cases/ . 2nd ed. St. Louis, a first-come, first-served basis, and IntracranialVet Ophthalmol extension of retrobulbar Tobias KM. Veterinary research scientists for the 21st century” documents/20110121223237788/1/ MO: Mosby Elsevier;2011:411–413. authors must request a waiver or blastomycosis ( ) Clinical Veterinary Advisor: Dogs on Monday morning. Choudhary S, Rathore K, Wang H-CR MIRCdocument.xml. Accessed March 17, reduction of fees from the publisher in a dog. 2011;14:137–141. Hecht S, Lawson SM, Lane IF, and Cats Laryngeal paralysis. In: Cote Information about other speakers, as well as 2011. before applying for this internal . Sharp DE E, ed. the call for abstracts, may be found at http://www. . 2nd ed. St. Louis, MO: Mosby Dr. Franziska Grieder of award. Differential induction of reactive oxygen Westermeyer HD, Hendrix DV, Ward DA. vet.utk.edu/research/symposium/. We will continue http://www.lib.utk.edu/openpub/More information, as well as species through Erk1/2 and Nox-1 by , Daniel GB. 99mTc-DTPACan Vet J Elsevier;2011:635–637. NCRR will give Monday’s to update the Web site with more information as it keynote address. theprogram.html application form, may be found FK228 for selectiveJ apoptosis Cancer Res of Clinoncogenic Oncol diuretic renal scintigraphy in dogs with nephroureterolithiasis. becomes available.  at H-Ras-expressing human urinary bladder O’Neill SH, Frank LA, Reynolds LM Long-term evaluation of the use of AhmedJ Am cancer J82 cells. 2010;51:1360–1366. . Choudhary S Wang H-CR Vetgonioimplants Med Assoc in dogs with primary 2011;137:471–480. . glaucoma: Nine cases (2000-2008). UTCVM Investigators Bring in $860,664 for Recent Sponsored Projects Westermeyer HD, Hendrix DV, Ward Effect of an anti-inflammatory doseVet 2011;238:610–617. , Wang K-KA, . DA, Cox SK. Title PI Agency Start Type $ Amount Oncogenic H-Ras, FK228, and exogenous ofDermatol prednisone on thyroid hormone 2 2 monitoring in hypothyroid dogs. H O cooperatively activated the ERKMol O’Neill SH, Newkirk KM, Anis EA, 2011;22:202–205. Tear, cornea, and aqueous Carcinogenesispathway in selective induction of human Brahmbhatt R, Frank LA, Kania SA humor concentrations of ciprofloxacin Investigation of a novel approach to forensic analysis using urinary bladder cancer J82 cell death. and moxifloxacin after topical ocular M Cekanova UT-Battelle/ORNL 1/28/11 Yr 1/1 147,213 Am J Vet Res neutron imaging techniques 2011;50:215–219, . application in ophthalmologically normal Legendre AM. Whitlock NC, Bahn JH, Lee S-H Detection of human papillomavirusVet Dermatol horses. 2011;72:398–403. AKC Canine Health Clemans JM, Deitz KL, Riedsel EA, Yaeger Baek SJ Genomic resources for the control of canine pyoderma S Kania 1/1/11 1/1 42,466 MJ, Retroperitoneal DNA in feline premalignant and invasive Foundation squamous cell carcinoma. , Eling TE, pyogranulomatous J andAm Vet Med fibrosing Assoc Gouffon . Resveratrol-induced apoptosis 2011;22:68–74. Mechanisms in herpetic keratitis B Rouse NIH 1/1/11 4/5 314,449 inflammation secondary to fungal JS, is mediated by early growthCancer response-1, Prev Res infections in two dogs. Rogers ED, Henry TB, Twiner MJ, Cox S, Yarbrough J Krüppel-like factor 4, and activating 2011:238:213–219. McPherson JT, Boyer GL, Sayler GS, transcription factor 3. T-regulatory cells in HSV immunity and immunopathology B Rouse NIH 2/1/11 4/5 356,536 . Determination of Wilhelm SW. Global gene expression 2011;4:116–127. firocoxib in equine plasma using high profiling in larval zebrafish exposed Recent Presentations In this Issue Bartges J. Pedigo A Odoi A. Vol. 6, Issue 1 Small animal case studies. , Aldrich T, Neighborhood Veterinary Conference; January 2011; Spring 2011 Van Amstel S. p1–UTCVM Research Office changes, OIT software; p2–Kalck, Newkirk, & Whitlock ITC grants, publications; Presentation at: UTCVM Annual disparities in stroke and heart attack Orlando, FL. Callens A. p3– PubMed Central, CEMPH Research Symposium, open access support, externally funded awards; p4– Conference; February 2011; Knoxville, TN. mortality in East Tennessee. Poster Medical conditions of presented at: Cardiovascular Disease presentations Getting on the right tract: pet pigs; Surgical conditions of pet pigs; Changes for the UTCVM Office of Research by Dr. Michael McEntee Epidemiology and Prevention 2011 Lameness in commercial and pet pigs. Urinary tract issues. Presentation at: Scientific Sessions; March 24, 2011; UTCVM Annual Conference; February Pedigo A Odoi A Invited presentations at: North American Craig L Atlanta, GA. Veterinary Conference; January 16, 2011; 2011; Knoxville, TN. Van Amstel S, , Aldrich T, . Place matters! Orlando, FL. he Greek philosopher Heraclitus said the only thing constant is change. As with everything in life, . . Synovial tumours in dogs. Disparities in ambulance response and this idea holds true for the UTCVM Office of Research and Graduate Studies, as well. In February, Presentation at: New Zealand Society Shearer JK, Cooper transport times for stroke and heart VL Clinical signs, histopathology and Dr. Leon Potgieter, Interim Associate Dean, retired and transferred his interim title onto Dr. Michael for Veterinary & Comparative Pathology attack patients in East Tennessee. Oral McEntee until a search for a non-interim replacement is complete. Annual Conference; February 13, 2011; treatment of atypical digital dermatitis Davis J. presentation at: Cardiovascular Disease The college has set research/discovery and clinical service as priorities in strategic planning for Palmerston North, New Zealand. in cattle. Presented at: International T Epidemiology and Prevention 2011 Ruminant Lameness Symposium; March 3, the next 5 years. With discovery, it is important to examine our strengths and build on them, recognizing Dermatology techniques and Scientific Sessions; March 25, 2011; Van Amstel S, Pluchino L, Wang H-CR. 2011; Rotorua, New Zealand. that we lack the infrastructure and critical mass of larger institutions. While we do have productive, special tips lab. Presentation at: UTCVM Atlanta, GA. well-funded research programs in basic biomedical, translational, and clinical medicine, there has been Annual Conference; February 2011; Shearer JK. Pathogenesis Frank L. The role of relatively little collaboration between groups to provide the synergy necessary to achieve the broader Knoxville, TN. and differentiation of toe lesions in cattle. HSD11B2 in the regulation of cellular Presented at: International Ruminant scope that might attract funding for program or training grants, or significant foundational support. Alopecia–Is it hormonal?; The itchy properties. Poster presented at: The Lameness Symposium; March 3, 2011; As we go forward in building our research enterprise, it will be important to consider how to Wang H-CR cat; Managing canine otitis. Presentations University of Tennessee/Oak Ridge Rotorua, New Zealand. buttress and expand our current areas of strength with strategic hires and development of collaborations at: UTCVM Annual Conference; February National Laboratory Graduate School of Miller DL. across campuses and the state. This will not happen overnight and will require a college-wide discussion 2011; Knoxville, TN. Genome Science & Technology Annual . In vitro progressive cellular Retreat; March 4, 2011; Knoxville, TN. carcinogenesis model. Invited presentation about where our strengths reside and where we might consider focusing in the longer term. Should Gray MJ, Duffus ALJ, Ecology Rathore K, Wang H-CR Abstract 26. at: NIMBioS Investigative Workshop – Solid we direct efforts toward major funding agencies (NIH, USDA, DOD), our clinical strengths, and/or what and pathology of ranaviruses. Workshop Tumor Modeling; January 2011; Knoxville, would arguably benefit Tennesseeans and their agriculture? What do we have now in people, facilities, presented at: Southeastern Partners in . Green tea Wells J. TN. or location that gives us an edge in addressing problems that are backed by funding sources? Amphibian and Reptile Conservation catechins at non-cytotoxic levels suppress Annual Meeting; February 2011; Louisville, cellular carcinogenesis induced by Acute renal failure. Presentation Just as important is to ensure veterinarians have an increasing role in biomedical research, Hecht S. at: UTCVM Annual Conference; February not only for the health of our profession, but because DVMs can contribute a unique perspective and MS. environmental carcinogens. Poster Whittemore J 2011; Knoxville, TN. knowledge-base highly relevant to a wide range of topics from human and animal Small animal applications of presented at: The University of Tennessee/ health to the environment. How do we in the UTCVM help increase the number magnetic resonance imaging–Update. Oak Ridge National Laboratory Graduate . Presumptive steroid Presentation at: UTCVM Annual School of Genome Science & Technology hepatotoxicity in dogs and cats. Presented of DVMs actively engaged in scientific discovery and contributing to our global Kennedy M. Annual Retreat; March 4, 2011; Knoxville, health? Conference; February 2011; Knoxville, TN. Schumacher J. at: Comparative Gastroenterology Society TN. Abstract 27. Annual Conference; March 2011; Manuel We have a small research footprint compared to many other colleges of Immunology. Lectures Wilson M Antonio, Costa Rica. veterinary medicine, and we lack the engine of a robust local biomedical research presented at: Western States Veterinary There is a snake in room Conference; February 24, 2011; Las Vegas, #!#!: Handling and clinical procedures for . Small animal oncology: The environment often provided by larger medical schools; so we need to build a LeBlanc A NV. snakes; Hypothermia is not appropriate veterinary technician’s role. Presentation strength internally (difficult to imagine more than one or two overlapping) and/