TACC2 Antibody

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Product Datasheet TACC2 Antibody Catalog No: #AB43154 Orders: [email protected] Description Support: [email protected] Product Name TACC2 Antibody Host Species Rabbit Clonality Polyclonal Purification Antigen affinity purification. Applications WB IHC Species Reactivity Hu Ms Specificity The antibody detects endogenous levels of total TACC2 protein. Immunogen Type peptide Immunogen Description Synthetic peptide of human TACC2 Target Name TACC2 Other Names AZU-1; ECTACC Accession No. Swiss-Prot#: O95359Gene ID: 10579 Calculated MW 310kd Concentration 2mg/ml Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage Store at -20°C Application Details Western blotting: 1:200-1:1000 Immunohistochemistry: 1:25-1:100 Images Gel: 6%SDS-PAGE Lysate: 40 µg Lane: Mouse muscle tissue Primary antibody: 1/300 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 minutes Address: 8400 Baltimore Ave. Suite 302 College Park MD 20740 USA http://www.abscitech.com 1 Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #43154 at dilution 1/30. Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #43154 at dilution 1/30. Background Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.? Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave. Suite 302 College Park MD 20740 USA http://www.abscitech.com 2.

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TACC1–Chtog–Aurora a Protein Complex in Breast Cancer
Oncogene (2003) 22, 8102–8116 & 2003 Nature Publishing Group All rights reserved 0950-9232/03 $25.00 www.nature.com/onc TACC1–chTOG–Aurora A protein complex in breast cancer Nathalie Conte1,Be´ ne´ dicte Delaval1, Christophe Ginestier1, Alexia Ferrand1, Daniel Isnardon2, Christian Larroque3, Claude Prigent4, Bertrand Se´ raphin5, Jocelyne Jacquemier1 and Daniel Birnbaum*,1 1Department of Molecular Oncology, U119 Inserm, Institut Paoli-Calmettes, IFR57, Marseille, France; 2Imaging Core Facility, Institut Paoli-Calmettes, Marseille, France; 3E229 Inserm, CRLC Val d’Aurelle/Paul Lamarque, Montpellier, France; 4Laboratoire du cycle cellulaire, UMR 6061 CNRS, IFR 97, Faculte´ de Me´decine, Rennes, France; 5Centre de Geńe´tique Molećulaire, Gif-sur-Yvette, France The three human TACC (transforming acidic coiled-coil) metabolism, including mitosis and intracellular trans- genes encode a family of proteins with poorly defined port of molecules, is progressing but many components functions that are suspected to play a role in oncogenesis. remain to be discovered and characterized. We describe A Xenopus TACC homolog called Maskin is involved in here the interaction of the TACC1 protein with several translational control, while Drosophila D-TACC interacts protein partners that makes it a good candidate to with the microtubule-associated protein MSPS (Mini participate in microtubule-associated processes in nor- SPindleS) to ensure proper dynamics of spindle pole mal and tumoral cells. microtubules during cell division. We have delineated here In
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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Review TACC1 (transforming, acidic coiled-coil containing protein 1) Ivan Still, Melissa R Eslinger, Brenda Lauffart Department of Biological Sciences, Arkansas Tech University, 1701 N Boulder Ave Russellville, AR 72801, USA (IS), Department of Chemistry and Life Science Bartlett Hall, United States Military Academy, West Point, New York 10996, USA (MRE), Department of Physical Sciences Arkansas Tech University, 1701 N Boulder Ave Russellville, AR 72801, USA (BL) Published in Atlas Database: December 2008 Online updated version : http://AtlasGeneticsOncology.org/Genes/TACC1ID42456ch8p11.html DOI: 10.4267/2042/44620 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2009 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Note: - AK304507 and AK303596 sequences may be suspect Other names: Ga55; DKFZp686K18126; KIAA1103 (see UCSC Genome Bioinformatics Site HGNC (Hugo): TACC1 (http://genome.ucsc.edu) for more details. - Transcript/isoform nomenclature as per Line et al, Location: 8p11.23 2002 and Lauffart et al., 2006. TACC1F transcript Note: This gene has three proposed transcription start includes exon 1, 2 and 3 (correction to Fig 6 of Lauffart sites beginning at 38763938 bp, 38733914 bp, et al., 2006). 38705165 bp from pter. Pseudogene DNA/RNA Partially processed pseudogene: - 91% identity corresponding to base 596 to 2157 of Description AF049910. The gene is composed of 19 exons spanning 124.5 kb. Location: 10p11.21. Location base pair: starts at 37851943 and ends at Transcription 37873633 from pter (according to hg18-March_2006).
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TACC2 Polyclonal Antibody Catalog Number:11407-1-AP 2 Publications
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