JOURNAL OF CLINICAL MICROBIOLOGY

VOLUME 9 * NUMBER 2 0 FEBRUARY 1979 EDITORIAL BOARD ALBERT BALOWS, Editor-in-Chief (1979) HENRY D. ISENBERG, Editor (1979) Centerfor Disease Control, Long Island Jewish-Hillside Medical Center, Atlanta, Ga. New Hyde Park, N. Y LORRAINE FRIEDMAN, Editor (1982) NATHALIE J. SCHMIDT, Editor (1980) Tulane University Medical School, California Department of Health, , La. Berkeley, Calif

Donald G. Ahearn (1981) Norman L. Goodman (1980) Demosthenes Pappagianis (1980) Libero Ajello (1979) Morris A. Gordon (1981) Robert H. Purcell (1980) William L. Albritton (1981) Dieter Groschel (1980) William E. Rawls (1980) Stephen D. Allen (1981) Pekka Halonen (1981) L. Barth Reller (1980) Daniel Amsterdam (1980) James L. Hardy (1981) Glenn D. Roberts (1980) Arthur L. Barry (1981) William J. Hausler, Jr. (1981) Jon E. Rosenblatt (1980) Barry Beaty (1981) Kenneth L. Herrmann (1979) Sally Jo Rubin (1980) John F. Bennett (1979) Harry R. Hill (1980) Julius Schachter (1980) Edward J. Bottone (1980) Lillian V. Holdeman (1979) Alexis Shelokov (1979) Don J. Brenner (1980) Milton Huppert (1981) Marcelino F. Sierra (1981) Sotiros D. Chaparas (1979) S. S. Kalter (1981) Margarita Silva-Hutner (1980) William B. Cherry (1981) Leo Kaufman (1981) Robert M. Smibert 11 (1981) Wallace A. Clyde, Jr. (1979) Douglas S. Kellogg (1981) James W. Smith (1980) B. H. Cooper (1980) George E. Kenny (1979) Peter B. Smith (1979) Richard F. D'Amato (1980) Wesley E. Kloos (1979) Vera L. Sutter (1979) Jules L. Dienstag (1980) George P. Kubica (1979) Patricia E. Taylor (1979) Richard E. Dixon (1981) Laurence R. McCarthy (1980) Welton I. Taylor (1980) Steven D. Douglas (1981) James D. MacLowry (1980) John H. Thompson, Jr. (1980) Walter R. Dowdle (1979) Harold Markowitz (1980) Richard C. Tilton (1981) V. R. Dowell, Jr. (1980) William J. Martin (1980) Alexander von Graevenitz (1980) Bennett L. Elisberg (1979) John M. Matsen (1980) I. Kaye Wachsmuth (1981) Richard W. Emmons (1980) Joseph L. Melnick (1979) Kenneth W. Walls (1980) Richard Facklam (1979) William I. Metzger (1980) Joseph L. Waner (1980) John J. Farmer III (1979) Stephen A. Morse (1980) Lawrence G. Wayne (1980) John C. Feeley (1980) C. Wayne Moss (1980) Tracy D. Wilkins (1981) James D. Fenters (1979) Maurice A. Mufson (1980) Hazel Wilkinson (1980) M. Finegold (1979) Harold C. Neu (1979) Robert P. Williams (1981) Maxwell Finland (1980) Richard A. Ormsbee (1979) Marion E. Wilson (1980) Herman Friedman (1981) Arvind A. Padhye (1981) Kwei-Hay Wong (1980) Thomas L. Gavan (1980) Barbara G. Painter (1980) Robert H. Yolken (1981) Robert C. Good (1979) Robert A. Day, Managing Editor Gisella Pollock, Assistant Managing Editor Bethany J. Brown, Production Editor 1913 I St., NW, Washington, DC 20006 EX OFFICIO Edwin H. Lennette, President (1978-1979) Willis A. Wood, President-Elect (1978-1979) J. Mehsen Joseph, Secretary Brinton M. Miller, Treasurer

The Journal of Clinical Microbiology (ISSN 0095-1137), a publication ofthe American Society for Microbiology, 1913 I St., Second-class postage paid at Washington, DC 20006, and at NW, Washington, DC 20006, is devoted to the dissemination additional mailing offices. ofnew knowledge concerning the applied microbiological aspects Made in the United States of America. of human and animal infections and infestations, particularly Copyright © 1979, American Society for Microbiology. regarding their etiologic agents, diagnosis, and epidemiology. All Rights Reserved. Papers dealing with antibiotics and antimicrobial agents and chemotherapy, with fundamental aspects of infection and im- munity, and with food or dairy microbiology fall within the scope The code at the top of the first page of an article in this journal ofother ASM publications. Instructions to Authors are published indicates the copyright owner's consent that copies of the article in the January issue each year. The Journal is published monthly, may be made for personal use, or for personal use of specific and the twelve numbers are divided into two volumes per year. clients. This consent is given on the condition, however, that the The nonmember subscription price is $60 per year. The member copier pay the stated per-copy fee through the Copyright Clear- subscription price is $16 per year. Single copies are $6. Corre- ance Center, Inc., P.O. Box 765, Schenectady, New York 12301, spondence relating to subscriptions, reprints, defective copies, for copying beyond that permitted by Sections 107 or 108 of the availability of back issues, lost or late proofs, disposition of U.S. Copyright Law. This consent does not extend to other kinds submitted manuscripts, and general editorial matters should be of copying, such as copying for general distribution, for advertis- directed to the ASM Publications Office, 1913 1 St., NW, Wash- ing or promotional purposes, for creating new collective works, ington, DC, 20006 (area 202 833-9680). or for resale. Author Index Abe, Yoshifumi, 284 Harrington, Rube, Jr., 194 Price, P., 170 Abshire, Robert L., 274 Hartman, Ella, 227 Pyndiah, N., 170 Adams, Mary R., 163 Hechemy, Karim E., 292 Aff, C., 294 Himes, Elmer M., 194 Randall, Eileen L., 248 Albrecht, Paul, 259 Holten, Eirik, 186 Raymundo, L., Jr., 205 Almeida, Regina G., 288 Hunter, Elizabeth F., 163 Reis, M. Henriqueta L., 288 Arnon, S. S., 282 Richardson, Neville J., 227 Ayers, Leona W., 239 Inouye, Sakae, 284 Rosen, Clifford, 299 Roux, Daniel J., 227 Barnishan, Jean, 239 Jarnagin, Jerald L., 194 Rubin, Sally Jo, 208 Barr, Judith, 180 Katz, D. Sue, 301 Bartlett, Raymond C., 236 Kohler, Richard B., 253 Salventi, John F., 248 Bergdoll, Merlin S., 266 Koornhof, Hendrik J., 227 Sasowski, Sandra, 292 Bokkenheuser, Victor D., 227 Krech, U., 170 Sato, Hiroshi, 259 Bryant, J. David, 175 Krugman, Saul, 259 Schlossberg, David, 297 Bryner, John H., 227 Kurzynski, Terrence A., 189 Schutte, Awie B., 227 Buck, Larry L., 299 Schwan, Olof, 157 Larsen, Sandra A., 163 Smith, Thomas F., 197 Casper, Elizabeth A., 292 Lombard, George L., 274 Snowden, S., 282 Chappelka, A. R., 294 Sobieski, Rodney J., 301 Citron, Diane, 214 McIntosh, Kenneth, 269 Sourek, Jiri, 266 McLaughlin, James C., 236 Stevens, Roy W., 292 D'Amato, Richard F., 244 Massanari, R. Michael, 280 Sutter, Vera L., 214 Davies, Terri A., 248 Matejovska, Vra, 266 Dickman, M. D., 294 Meguro, Hidenori, 175 Tenney, James H., 197 Douglas, George W., 299 Meiklejohn, Gordon, 269 Thoen, Charles O., 194 Dowell, V. R., Jr., 274 Meise, Cheryll K., 189 Toledo, M. Regina F., 288 Drew, W. L., 205 Mertens, A., 233 Tomfohrde, Karla M., 244 Dykstra, Mark A., 236 Michaelson, Edith E., 292 Torrence, Anne E., 175 Midura, T. F., 282 Trabulsi, Luiz R., 288 Ennis, Francis A., 259 Montgomery, K., 205 Trojanova, Marie, 266 Murcia, Alejandro, 208 Fenton, Lawrence J., 167 Murray, Patrick R., 290 Viner, John P., 280 Finegold, Sydney M., 214 Vymola, Frantisek, 266 Fishaut, Mark, 269 Nadler, Harriette, 180 Freiman, Ida, 227 Nagler, J., 233 Washington, John A. II, 197 Waters, John R., 248 George, Harvey, 180 Oberhofer, Thomas R., 220 Wheat, L. Joseph, 253 George, W. Lance, 214 Orcutt, R. P., 294 Whitaker, Susan, 248 Gepts-Friedenreich, E., 233 Orrison, Leta H., 163 White, Arthur, 253 Gerhard, J., 294 Overman, Timothy L., 244 Wilhelm, J., 170 Greenwood, J. R., 200 Wood, R. M., 282 Pender, Barbara J., 163 Wright, Peter F., 175 Hansen, W., 233 Philip, Robert N., 292 Harper, Marilyn H., 167 Pickett, M. J., 200 Zelenkova, Ludmila, 266 The most up-to-date survey of microbial pathogenesis -

M IClOf IOLOCKf Editor: David Schlessinger //D/ Publication Date: February 1979 ...

Contents by Section: Microbial Membranes 0 Mechanisms of Microbial Virulence 0 Biochemical Genetics of Pathogenicity 0 Antibiotic- Associated Colitis 0 Resistant Gram-Positive Cocci 0 Mutasynthesis of Antibiotics 0 Ontogeny of the Immune System

Clothbound. 356 pages. ISBN: 0-914826-20-4. $22.00. (Members of ASM may purchase this title, for personal use only, at the special price of $12.00. All member orders must be accompanied by payment, and overseas orders must be prepaid before the order is shipped). Send all orders and 1913 Street, NW inquiries to the publisher: Washington, DC 20006 merican Society for Microbiology INDEX TO ADVERTISERS Page * Analytab Products ...... Cover 2 Biotrol Co ,..... 11 Charles C. Thomas Publishers ...... 14 * Clinical Sciences, Inc...... Cover 4 * Difco Laboratories ...... 16 General Diagnostics ...... 5 * Heinicke Instruments ...... 9 * Johnston Laboratories ...... 12 * Marion Scientific .15 * McDonnell Douglas ...... 13 Micro-Media Systems ...... Cover 3 C.V. Mosby Co ... 8 Pharmacia Diagnostics ...... 7...... 7

* Sustaining Member, American Society for Microbiology.

Advertising in this journal is limited to products and services believed to be of interest to the readers. However, ASM does not test nor examine advertised products nor claims related thereto. Therefore, ASM endorsement or approval of advertised products should not be inferred.