The Breast Cancer Research Foundation Winter 2006

A Message fromPINK Evelyn Lauder, PRESS Founder and Chairman You will be delighted to know that The Breast Cancer Research Foundation is truly at the forefront of major news in breast cancer research advances. BCRF grantees are working together, sharing ideas to use resources effectively and maximize results. Having already supported the NCI-directed clinical trials cooperative groups around the U.S. for a number of years, the Medical Advisory Board led us to adopt two new collaborative projects this year:

First, our funds have provided founding support for the Breast Cancer Research Consortium, representing leading researchers from top medical centers across the U.S. to speed clinical trials evalu- ating new cancer treatments. The Consortium will conduct tests of new drugs in all stages of breast cancer, including trials of promising preventive ratt treatments. These tests will emphasize the biology and genetics of breast cancer and will draw ulie Skar connections between the molecular biology of the J tumor and the response to new classes of drugs. Photo:

The Consortium will also design new clinical Evelyn Lauder, Laura Lassman, Myra Biblowit, René Syler trials, emphasizing “pre-operative” testing in women before surgery and trials measuring the growth of tumors, blood vessels and the metabo- BCRF’S SYMPOSIUM AND LUNCHEON lism of cancer cells. This is the first group of its kind sustained without Breast Cancer Now Versus Then government funding and

t we hope BCRF’s From the lipstick prints of a well-wisher visible on Dr. Larry Norton’s right cheek continuing support will pehar attract other donors. to Evelyn Lauder and René Syler’s convivial emcee exchanges, the October 18th Symposium and Awards Luncheon of The Breast Cancer Research Foundation Lucien Ca Secondly, a pilot BCRF (BCRF) had a celebratory feel. grant is bringing together

Photo: two of the world’s largest cooperative organizations And with good reason. First, the Luncheon, attended by more than 1,070 people, for breast cancer clinical trials: The Breast Cancer raised over $1.7 million. The Foundation awarded a record $22 million in grants Intergroup of North America and the Breast International Group. With BCRF funding, to 110 researchers studying the disease at major academic medical centers across members of both groups have begun a truly global the and in seven countries abroad, in what Lauder described as “the collaboration aimed at integrating their respective scientific programs, and cooperative planning of Academy Awards of Medicine” — the BCRF founder’s witty recognition of the clinical trials and treatment. They first met in caliber of breast cancer researchers receiving grants. December 2005, in conjunction with the San Antonio Breast Cancer Symposium. Then there was the status of breast cancer research and treatment itself. Norton, How thrilling it is to be fostering such historic scientific director and chairman of BCRF’s Medical Advisory Board, described it: alliances so we can help advance the frontiers of “We can see a finish line now.” Norton reminded the audience during the opening medical research. We are ever grateful for your contributions to our efforts as we race towards our remarks of BCRF’s morning Symposium at ’s Waldorf=Astoria Hotel goal of prevention and a cure. We’d like to be the that celebration of what we have collectively accomplished is appropriate, as long first at the finish line. as we maintain stamina for completing the race. (Continued on page 2)

symposium and luncheon Waldorf=Astoria Hotel’s Chef Jean-Claude Perennou’s (Breast Cancer Now Versus Then Continued) Low-Fat Mousse Recipe Now in its twelfth year of funding research in breast cancer, BCRF recognized quality-of- life researcher Patricia Ganz, MD, with the 2005 Jill Rose Award. The award, established 1 LB Manjari Chocolate ten years ago, honors outstanding scientific research and the legacy of the late Jill Rose, a 2 OZ Butter 3 OZ Sugar BCRF founding member. Ganz is an oncologist who directs the Division of Cancer 14 Egg Whites Prevention & Control Research at UCLA’s Jonsson Cancer Center where she leads the (Serves 15) Patients and Survivors Research Program. She has pursued quality-of-life research since, Combine the chocolate and butter in a saucepan and melt as she said, “the days when it was really unconventional to do so.” That was 20 years ago. together over low heat; set aside. Because of her research, clinicians may guide their patients into the post-treatment phase with greater support and appropriate expectations. On accepting the award Ganz told the In a separate bowl, combine the sugar and egg whites. Whisk or beat on high speed until the egg whites form stiff peaks to form audience, “it is a privilege to practice medicine,” and that her role as an oncologist has a meringue. helped her better understand life after breast cancer. Fold the meringue mixture quickly into the melted chocolate and refrigerate for several hours. Enjoy! First Lady of State Libby Pataki recognized the renowned artist Chuck Close with BCRF’s Humanitarian Award. Close said modestly upon acceptance of the award Sue-Ann Friedman and that his wife, a breast cancer survivor, and other survivors, are the heroes who are more Roslyn Goldstein deserving of recognition.

At every turn of the day’s events researchers and survivors described how different the prospects are for patients with breast cancer today as a result of research advances over the past decade. In a poignant video produced by Brian Litman and introduced by BCRF president Myra Biblowit, survivors and their families underscored the impact of improved treatments and better outcomes. With the message of accomplishment in the ongoing face of hope, another message was also clear: the strides of research could not have been achieved without the foresight and support of BCRF.

The Symposium and Luncheon were made possible by underwriters Roslyn and Leslie Goldstein and longstanding corporate sponsor, Roche. The Foundation also thanks Benefit Co-Chairs Anne Eisenhower Flöttl, Betsy Green, Ronnie Heyman, Gail Hilson, Evelyn Lauder, Gigi Mortimer, and Elizabeth Rohatyn.

Jane Lauder, Jamee Gregory, Dr. Funmi Olopade and Jo Carole Lauder Dr. Laura Esserman Evelyn Lauder and William Lauder Molly Wallace and Cynthia Shipper Gail Hilson ratt ulie Skar J Patrick McMullan (Jimi Celeste) Patrick McMullan (Jimi Celeste) Marshall Rose, Dr. Patricia Ganz, Myra Biblowit, Evelyn Lauder, Dr. Larry Norton. Front row: Dr. Patricia Ganz, Dr. Pamela Goodwin, Dr.Annette Stanton, Unless otherwise noted all photos: Wendi Rose Photo: Libby Pataki and Chuck Close Photo: Leonard Lauder Susan Rudin Dr. Electra Paskett, Dr. Edith Perez Linda Lindenbaum and Renée Belfer

2 The Breast Cancer Research Foundation Winter Newsletter 2006 3

about us scientific retreat BOARD OF DIRECTORS LETTER FROM OUR PRESIDENT Evelyn H. Lauder, Chairman Dear Friends: Myra J. Biblowit, President Jeanette S.Wagner, Vice President In October we awarded $22 million to 110 researchers, our largest Deborah Krulewitch, grant-making program ever. We now fund investigators at renowned Secretary and Treasurer medical centers in the United States, Canada, Europe, Israel and Latin Carolee Friedlander America. The Breast Cancer Research Foundation’s mission of preven- CHANGE THE DISEASE, CHANGE THE SURVIVAL Carlyn S. McCaffrey, Esq. tion and a cure for breast cancer in our lifetime has truly become a worldwide effort. Josie Robertson Quality of life research center stage at public symposium, scientific retreat Just as the research we fund is critical, spreading the word about the importance of ADVISORY BOARD research is vital to BCRF’s growth. One of the most effective ways we can impact the health of men and women across the globe is to enlighten people about the Foundation’s Roberta M. Amon “We’ve changed the natural history of breast cancer through better detection and Andrea Bronfman work. This fall the BCRF staff spoke to employees at Coach, Movado, Song, and Karen Neuburger, encouraging them to join us in our mission. We have reached out to the next treatment,” said Pamela Goodwin, MD, Professor of Medicine, Mt. Sinai Hospital, Mary Bryant University of Toronto. Her remark as a panelist at the scientific Symposium that Susan Payson Burke generation with college fundraising programs and held our first Junior event, attracting Rena Rowan Damone over 300 young New Yorkers eager to support a cause that touches so many. This fall the preceded the annual BCRF Luncheon in October underscored the changes that Ute Dugan, MD, PhD Foundation was honored with inaugural events in Lexington, Kentucky, and in Boston, research has brought to breast cancer and complemented Jill Rose Suzanne Elson and Toronto. Through Play for P.I.N.K. tournaments and Danskin Triathlons Awardee Dr. Patricia Ganz’s explanation of what question drives a new Janet Fisher we reach over 100,000 people nationwide. Our network of BCRF ambassadors contin- generation of research: “What is the impact of primary breast cancer Anne Eisenhower Flöttl ues to grow. Wherever we go, I am moved by how people are impacted by this disease treatments on women’s health?” Kim Garner and what motivates them to give back. Amy P.Goldman, PhD This year’s public Symposium panel consisted of five top, female breast Marjorie Reed Gordon Our donors around the world, so generous in spirit and deed, truly are the engine that Lorna Hyde Graev fuels The Breast Cancer Research Foundation. At this moment in time, when research is cancer researchers including Ganz, an oncologist who heads the Division Betsy S. Green advancing at an unprecedented pace, when there is a renaissance of biomedical science, of Cancer Prevention & Control at UCLA’s Jonsson Cancer Center; Bette-Ann Gwathmey the investments that BCRF makes are having an enormous impact on every continent. Goodwin; Annette Stanton, PhD, Professor of Psychology and Lori Hall To all of you who have helped us tell our story to new audiences, thank you for being Psychiatry/Behavioral Sciences at UCLA; Electra Paskett, PhD, Ronnie Heyman our ambassadors. Your enthusiasm, your commitment and your support translate into a Professor of Cancer Research in the School of Public Health at Ohio Paul Schneck Gail Hilson brighter future for women everywhere.

State University, and Edith Perez, MD, Professor of Medicine at Mayo Photo: Susan B. Hirschhorn Robin J. Kemper Sincerely, College of Medicine in Rochester, Minnesota. Dr.Arnold Levine, Patricia Quick de Visscher, Francois de Visscher, Peg Mastrianni Kitty Kempner Rochelle Kivell In their nearly two-hour discussion followed by a Q & A session, the five scientists, led Sandra Krakoff Myra J. Biblowit by Ganz’s opening summary of the field of quality of life research, revealed important Sheila C. Labrecque President insights: Amy Langer Laura Lassman Ellen Levine Nancy Novogrod I Treatment for breast cancer has been shortened to 2-9 months over the Ellen Odoner, Esq. CONGRATULATIONS TO BCRF RESEARCHERS… past 20 years, but recovery often takes 2 years or more. BCRF MEDICAL Mary Alice Pappas ADVISORY BOARD Alexandra Penney José Baselga, MD, Chairman of Medical Oncology and Professor of Medicine at Vall I Women are primarily concerned with the risk of death due to breast cancer, Winifred Gorlin Phillips d'Hebron University Hospital in Barcelona, Spain, was named President-Elect of the making them willing to undergo difficulties associated with long courses of Chairman and Scientific Director Jane Pontarelli European Society of Medical Oncology (ESMO). Dr. Baselga also received the 2005 ESMO Award for his "outstanding contribution in the field of medical oncology." chemotherapy. Larry Norton, MD Lynda Resnick Memorial Sloan-Kettering Wendi Rose Cancer Center Pat Rosenwald H. Shelton Earp III, MD, Director of the Lineberger Comprehensive Cancer Center and I Breast cancer patients are resilient women. However, high-risk groups include: Valerie Salembier Professor of Medicine and Pharmacology at the University of North Carolina, was named young women whose fertility is jeopardized by treatment and women who lack President of the Association of American Cancer Institutes. Members Suzanne Santry family or social support while undergoing treatment. Judith P.Schlager Nancy Davidson, MD Gabriel N. Hortobagyi, MD, FACP, Chairman of the Department of Breast Medical Johns Hopkins University Muriel Siebert Oncology and Professor of Medicine at the University of Texas, MD Anderson Cancer I Anne Sitrick Remarkably, many patients experience measurable personal growth as a result Center, was named President-Elect of the American Society of Clinical Oncology (ASCO). of their cancer, reframing life priorities. Peter Greenwald, MD, Dr. PH Ruth Spear National Institutes of Health Linda Stein Olufunmilayo (Funmi) Olopade, MB, BS, FACP, founding director of the Center for Erana Stennett I Incremental return to pre-cancer activities is vital in the early survivorship Clinical Cancer Genetics and Professor of Medicine and Human Genetics at the University Gabriel N. Hortobagyi, MD Arlene Taub of Chicago Medical Center, was awarded a MacArthur Foundation Fellowship, a prestigious stage. University of Texas Missie R.Taylor five-year grant presented to 25 "individuals who show exceptional merit and promise for MD Anderson Cancer Center Wendy Wasserstein continued and enhanced creative work." Karen Webster Cathy Weinroth Geoffrey M. Wahl, PhD, Professor at the Salk Institute, was named President-Elect of the Harriet Weintraub American Association for Cancer Research (AACR). Sara Wolfensohn 4 The Breast Cancer Research Foundation Winter Newsletter 2006 5

scientific retreat

Goodwin explained that women’s weight is an indicator of recurrence. “Overweight and obesity have proven to be adverse qualities in breast cancer,” she said. Her studies have revealed that “insulin resistance syndrome” is a possible indicator that breast cancer risk and recurrence have increased. Goodwin advocates greater awareness about weight as a risk factor and changing lifestyle through food and exercise to reduce the risk. Paul Schneck

Edith Perez, MD, described her project of tracking women Anne Eisenhower Flöttl, Myra Biblowit, Evelyn Lauder,Wolfgang Flöttl, All Photos: taking the drug Herceptin for evidence of risk factors for cardiac Dr. Patrick Borgen Dr. Eduardo Cazap, Dr. Carlos Arteaga, Dr. Gabriel Hortobagyi disease. “There is a small but real risk,” says Perez, “and now we know how to carefully monitor and redirect those who will not respond well to the drug.” Kent Osborne, MD, of Baylor College of Medicine Perez and her colleagues made news in 2005, when the National Cancer Institute released presented research findings describing the evolving under- the results of two large clinical trials showing that Herceptin given with chemotherapy standing of estrogen and progesterone receptors in reduced recurrence of breast cancer in women with HER-2 positive breast cancer by 52 helping doctors decide which drugs to use for breast percent. Perez was the principal investigator for one of those trials. cancer treatment. “Measuring the level of progesterone receptors along with HER2 receptors may help to select Stanton has helped identify “islands of disruption” that breast cancer survivors experi- which type of endocrine therapy to use in individualizing treatment,” he noted. ence. Her research extends Ganz’s findings in determining risk groups among survivors. Dr.Albert Deisseroth, Betsy Green, Linda Stein Treatment for breast “Breast cancer is not the same experience for all women,” said Stanton. “Women who adopt an active approach to their experience fare particularly well, while others are at Also at the Retreat, Kathy Miller, MD, of Indiana School of Medicine, outlined her bioinformatics approach to under- cancer has been risk for depression.” She and her colleagues focus on strategies for supporting survivors standing how an individual’s genetic makeup predisposes her to success or failure with targeted drugs used to treat breast with different psychological needs. cancer — such as trastuzumab and bevacizumab. She suggested that this new information may help doctors prescribe the shortened to 2-9 best possible drug for treating breast cancer as well as form the basis for developing new targeted drugs. months over the By sifting through the Young Breast Cancer Survivor Cohort Study to determine overlooked factors in breast cancer survival, Paskett has learned that nearly 30 percent BCRF’s Symposium and Retreat engaged scientific and non-scientific attendees alike in vigorous discussion about breast past 20 years, but suffer chronic lymphedema—post-surgical swelling in the arms, due to removal of the cancer as a collection of diseases with increasingly manageable outcomes. Dr. Norton observed that breast cancer lymph nodes in many breast cancer surgeries. Now, using data from the historic research is revealing new insights in other areas of women’s health, such as heart disease, obesity, menopause and post- recovery often takes Women’s Health Initiative Study, she is striving to understand how lymphedema might menopause. As quite a few attendees pointed out, the research gains of scientists in the U.S. and other developed nations be prevented or reduced. “With such a supported by BCRF must be translated across the globe. Breast cancer is international and its improved treatments 2 years or more. high incidence of lymphedema in survivors, should be too. we must work on improving this chronic condition,” she told the audience. BCRF LEADERS COUNCIL Gail Hilson Anne Eisenhower Flöttl Nicole Limbocker Beverly Sills Perez, Goodwin and Ganz were also among Chairman Lorna Hyde Graev Carol Mack Nancy Silverman the five panelists at BCRF’s October 17th Roberta M. Amon Jamee Gregory Hillie Mahoney Anne Sitrick scientific Retreat. Now in its fourth year, the Jessie Araskog Audrey Gruss Ketty Maisonrouge Daisy Soros Retreat provides an opportunity for all Muffie Potter Aston Joanne de Guardiola Grace T. Meigher Louise M. Sunshine current BCRF grantees to learn about the Anne H. Bass Mai Hallingby Harrison Liz Mezzacappa Felicia Taylor research of their colleagues the day prior to Candice Bergen Dina Merrill Hartley Muffy Miller Joan H.Tisch Arlene Taub, Dr. Larry Norton, Muriel Siebert Magda Bleier Gale Hayman-Haseltine Nancy Missett Patricia Quick de Visscher the annual Luncheon and public Melinda Blinken Veronica Hearst Gigi Mortimer Adrienne Vittadini Symposium. Held at Memorial Sloan-Kettering Cancer Center, the Retreat has been Katherine Bryan Marlene Hess Deborah Norville Barbara Walters made possible each year since inception by support from BCRF Advisory Board member Susan Payson Burke Karen M. Karp Libby Pataki Patricia G.Warner Muriel Siebert. In closing this year’s program, Larry Norton, MD, emphasized that, “this Catherine Cahill Kitty Kempner Jean H. Pearman Thorunn Wathne annual gathering actually spawns new research collaborations.” Patty Cisneros Eleanora Kennedy Carroll Petrie Harriet Weintraub Norma Dana Coco Kopelman Pauline Pitt Saundra Whitney Beth Rudin DeWoody Jo Carole Lauder Annette de la Renta Vivien Wyser-Pratte Barbaralee Diamonstein- Karen Lauder Josie Robertson Paula Zahn Spielvogel Karen LeFrak Pat Rosenwald Robin Chandler Duke Wendy Vanderbilt Lehman Hilary Geary Ross HRH Princess Firyal Memrie M. Lewis Christine Hearst Schwarzman

6 The Breast Cancer Research Foundation Winter Newsletter 2006 7

2005 - 2006 grantees Stuart A. Aaronson, MD Graham A. Colditz, MD, Harold P. Freeman, MD Mien-Chie Hung, PhD Richard R. Love, MD, MS Electra D. Paskett, PhD Ruby T. Senie, PhD Mary Beth Terry, PhD Mount Sinai School of Medicine Dr.PH Ralph Lauren Center for Cancer University of Texas International Breast Cancer The Ohio State University Mailman School of Public Mailman School of Public New York, NY Brigham & Women’s Hospital Care and Prevention MD Anderson Cancer Center Research Foundation The Play for P.I.N.K. Award Health Health Harvard Medical School New York, NY Houston, TX Ohio State University Columbus, OH Columbia University Columbia University D. Craig Allred, MD Boston, MA Columbus, OH New York, NY New York, NY Baylor College of Medicine Patricia A. Ganz, MD Stephen D. Hursting, PhD, MPH Edith A. Perez, MD Houston, TX Robert L. Comis, MD University of California, The University of Texas at Joan H. Marks, MS Mayo Clinic - Jacksonville, FL Vandana Sharma, MD, PhD Ilan Tsarfaty, PhD Eastern Cooperative Oncology Los Angeles Austin New York Breast Cancer Study Made possible by Roche Stanford University Sackler School of Medicine Carlos L. Arteaga, MD Group Los Angeles, CA Austin, TX Sarah Lawrence College Jacksonville, FL American Society of Clinical Tel Aviv University Vanderbilt University School of Coalition of Cancer Cooperative Bronxville, NY Oncology Tel Aviv, Israel Medicine Groups Judy E. Garber, MD, MPH J. Dirk Iglehart, MD Charles Perou, PhD Stanford, CA The First Step Award Philadelphia, PA Dana-Farber Cancer Institute Brigham and Women's Hospital John Mendelsohn, MD University of North Carolina George F. Vande Woude, PhD Nashville,2005-2006 TN Boston, MA Dana-Farber Cancer Institute GRANTEESUniversity of Texas Chapel Hill, NC Moshe Shike, MD Van Andel Research Institute Andrew J. Dannenberg, MD The Arthur and Rochelle Belfer MD Anderson Cancer Center Memorial Sloan-Kettering Grand Rapids, MI Jill Bargonetti, PhD Weill Medical College Teresa Gilewski, MD Foundation Award Houston, TX Hunter College Martine J. Piccart, MD, PhD Cancer Center Cornell University Memorial Sloan-Kettering Boston, MA Breast International Group New York, NY Kala Visvanathan, MBBS, City University of New York New York, NY Cancer Center Sofia D. Merajver, MD, PhD New York, NY Tan A. Ince, MD, PhD University of Michigan Institut Jules Bordet FRACP, MHS The Play for P.I.N.K. Award Brussels, Belgium George W. Sledge, MD Johns Hopkins Bloomberg School New York, NY Whitehead Institute for Comprehensive Cancer Center José Baselga, MD Nancy E. Davidson, MD Indiana University School of of Public Health Johns Hopkins University School Biomedical Research Ann Arbor, MI Vall d’Hebron University Pamela J. Goodwin, MD, Cambridge, MA Lori J. Pierce, MD Medicine Made possible by Roche Hospital of Medicine MSc, FRCPC Kathy D. Miller, MD University of Michigan Indianapolis, IN Baltimore, MD Barcelona, Spain Breast Cancer Clinical Trials Mount Sinai Hospital James N. Ingle, MD Indiana University School of Ann Arbor, MI Consortium University of Toronto Mayo Clinic - Rochester, MN Medicine Benjamin Smith, MD Geoffrey M. Wahl, PhD Robert Benezra, PhD Baltimore, MD Toronto, Ontario, Canada Rochester, MN Made possible by Genentech Peggy L. Porter, MD Yale University School of Salk Institute for Biological Memorial Sloan-Kettering Indianapolis, IN Fred Hutchinson Cancer Medicine Studies Cancer Center Albert B. Deisseroth, MD, Julie R. Gralow, MD Benita S. Katzenellenbogen, Research Center American Society of Clinical La Jolla, CA The Play for P.I.N.K. Award PhD University of PhD Hyman B. Muss, MD Southwest Oncology Group Oncology New York, NY Sidney Kimmel Cancer Center Southwest Oncology Group University of at Urbana- University of Vermont Made possible by Macy’s The Hirschhorn Award Shaomeng Wang, PhD San Diego, CA Made possible by Macy’s Champaign Made possible by Roche , WA New Haven, CT University of Michigan Jean-Yves Blay, MD, PhD Seattle, WA Urbana, IL Burlington, VT Ann Arbor, MI Cancéropôle Lyon Rhône-Alpes Centre Léon Bérard Wei Wang, MD, PhD Lyon, France Fred Hutchinson Cancer Research Center Patrick I. Borgen, MD American Society of Clinical Memorial Sloan-Kettering Oncology

Cancer Center ratt Seattle, WA New York, NY

ulie Skar Robert A. Weinberg, PhD Jeffrey Boyd, PhD J Memorial Sloan-Kettering Whitehead Institute for Biomedical Research Cancer Center Photo: New York, NY Cambridge, MA Michael P. DiGiovanna, MD, Lyndsay N. Harris, MD Mary-Claire King, PhD Katherine L. Nathanson, MD Michael F. Press, MD, PhD Ian E. Smith, MD, FRCP Powel H. Brown, MD, PhD PhD Dana-Farber Cancer Institute New York Breast Cancer Study University of Pennsylvania Norris Comprehensive Cancer Royal Marsden Hospital and Ralph Weissleder, MD, PhD Baylor College of Medicine Yale University School of Cancer and Leukemia Group B University of Washington The Arthur and Rochelle Belfer Center Institute of Cancer Research General Hospital Houston, TX Medicine Boston, MA Seattle, WA Foundation Award University of Southern Made possible by AstraZeneca Harvard Medical School Made possible by Roche Philadelphia, PA California London, UK Boston, MA Joan S. Brugge, PhD New Haven, CT Sandra L. Harris, PhD Joshua LaBaer, MD, PhD Los Angeles, CA Harvard Medical School Cancer Institute of New Jersey Harvard Medical School Larry Norton, MD Lawrence J. Solin, MD Michael Wigler, PhD The Arthur and Rochelle Belfer H. Shelton Earp, MD University of Medicine & The Arthur and Rochelle Belfer Memorial Sloan-Kettering Lajos Pusztai, MD, D. Phil University of Pennsylvania Cold Spring Harbor Laboratory Foundation Award University of North Carolina Dentistry of New Jersey Foundation Award Cancer Center University of Texas Philadelphia, PA The Play for P.I.N.K. Award Boston, MA Chapel Hill, NC The Regina Quick Award Boston, MA The Peter Jay Sharp Foundation MD Anderson Cancer Center Cold Spring, NY Matthew J. Ellis, MD, PhD New Brunswick, NJ Award Houston, TX Christos Sotiriou, MD, PhD Christophe Caux, PhD Titia de Lange, PhD New York, NY Institut Jules Bordet Walter C. Willett, MD, Dr. PH Cancéropôle Lyon Rhône-Alpes Washington University School of Medicine Gabriel N. Hortobagyi, MD, The Rockefeller University Andrew A. Quong, PhD Brussels, Belgium Harvard School of Public Health Centre Léon Bérard FACP New York, NY Paul M. Nurse, PhD Georgetown University Made possible by Roche Lyon, France Cancer and Leukemia Group B St. Louis, MO University of Texas The Rockefeller University Washington, DC Annette L. Stanton, PhD Boston, MA Eduardo Cazap, MD MD Anderson Cancer Center Eva Y.-H P. Lee, PhD New York, NY University of California, Los SLACOM Laura J. Esserman, MD, MBA Houston, TX University of California, Irvine Neal Rosen, MD, PhD Angeles Eric P. Winer, MD Latin American-Caribbean University of California, San Irvine, CA Kenneth Offit, MD, MPH Memorial Sloan-Kettering Los Angeles, CA Dana-Farber Cancer Institute Society of Medical Oncology Francisco Kathryn B. Horwitz, PhD Memorial Sloan-Kettering Cancer Center Boston, MA Buenos Aires, Argentina , CA University of Colorado School of Arnold J. Levine, PhD Cancer Center The Joseph and Arlene Taub Vered Stearns, MD Medicine Cancer Institute of New Jersey New York, NY Foundation Award Johns Hopkins University School William C. Wood, MD Jenny Chang, MD Zhen Fan, MD Denver, CO University of Medicine & New York, NY of Medicine Emory University on behalf of Baylor College of Medicine University of Texas Dentistry of New Jersey Funmi I. Olopade, MB, BS, Baltimore, MD The Breast Cancer Intergroup Houston, TX MD Anderson Cancer Center Alan N. Houghton, MD The Regina Quick Award FACP Regina M. Santella, PhD & Breast International Group Houston, TX Memorial Sloan-Kettering New Brunswick, NJ Medical Mailman School of Public W. Fraser Symmans, MD Lewis A. Chodosh, MD, PhD Cancer Center Center Health University of Texas Richard C. Zellars, MD Abramson Family Cancer Judah Folkman, MD The Peter Jay Sharp Foundation Ephrat Levy-Lahad, MD Made possible by Roche Columbia University MD Anderson Cancer Center Johns Hopkins University Research Institute Children’s Hospital & Harvard Award Shaare Zedek Medical Center Chicago, IL New York, NY Houston, TX School of Medicine University of Pennsylvania Medical School New York, NY Jerusalem, Israel Baltimore, MD Philadelphia, PA Boston, MA C. Kent Osborne, MD Richard L. Schilsky, MD Antoinette R. Tan, MD, Michael F. Clarke, MD Hedvig Hricak, MD, PhD Marc E. Lippman, MD Baylor College of Medicine University of Chicago MHSc Stanford University School of James M. Ford, MD Memorial Sloan-Kettering University of Michigan Houston, TX Cancer and Leukemia Group B Cancer Institute of New Jersey Medicine Stanford University School of Cancer Center Ann Arbor, MI Chicago, IL University of Medicine & Stanford, CA Medicine New York, NY Barbara A. Parker, MD Dentistry of New Jersey Stanford, CA Philip O. Livingston, MD Moores Cancer Center Robert J. Schneider, PhD American Society of Clinical Margot P. Cleary, PhD Clifford Hudis, MD Memorial Sloan-Kettering University of California, NYU School of Medicine Oncology Hormel Institute Silvia Formenti, MD Memorial Sloan-Kettering Cancer Center San Diego New York, NY New Brunswick, NJ University of Minnesota NYU School of Medicine Cancer Center The Play for P.I.N.K. Award San Diego, CA Austin, MN New York, NY New York, NY New York, NY 8 The Breast Cancer Research Foundation Winter Newsletter 2006 9

events 14th ANNUAL ESTÉE LAUDER COMPANIES BREAST CANCER Target Pink Continues AWARENESS CAMPAIGN GIVES BREAST CANCER THE PINK SLIP Target kicked off Breast Cancer Awareness Month in with a free The Estée Lauder Companies Breast Cancer Awareness Campaign made October 2005 the most memorable Breast concert by the artist “Pink” who donated $50,000 to BCRF. Target also handed out Cancer Awareness month yet. Millions of pink ribbons were distributed and Aveda, Bobbi Brown, Donna Karan, Estée free coffee, doughnuts and MetroCards as part of a “Random Acts of Kindness Day.” Lauder, Jo Malone, La Mer, Origins, Prescriptives, Stila and Tommy Hilfiger created pink products, including Estée Target definitely hit the bull’s-eye again, raising $300,000 with their second Lauder Pure Color Crystal Gloss in Evelyn Pink. On September 14th, Evelyn Lauder, Elizabeth Hurley, spokesmodel for consecutive exclusive pink product collection. There were over 20 items this year, Estée Lauder and its Breast Cancer Awareness Campaign, Sean “Diddy” Combs and Bloomingdale’s Chairman and including pink polo shirts, a men’s tie, and cashmere flip-flops. A remarkable CEO Michael Gould, hosted “Give Breast Cancer the Pink Slip!,” a cocktail party in NYC to launch Mr. Combs’ “Pink 100 percent of the net profits benefit BCRF. Slip” camisole sold exclusively at select Bloomingdale’s to benefit BCRF. Continuing their awareness-boosting activities, on October 6th Evelyn Lauder and Elizabeth Hurley traveled to Saks Fifth Avenue in Boston and illuminated the Random Acts of Kindness in NYC Prudential Center. As always, the Estée Lauder Companies employees actively supported BCRF with their annual Sale-a-bration, on-line silent auction, Aramis bake sale, raffles, and La Mer sales as well as walks, golf, soccer and other sports outings.

Myra Biblowit accepts $50,000 check from Pink Buying Target pink products at the free “Pink” concert at the South Street Seaport, NYC

Pink Slip Lounge Evelyn Lauder announcing the kick-off of The Estée Lauder Companies’ 2005 Breast Cancer Awareness Campaign and thanking Sean “Diddy” Combs for designing the fabulous pink camisole she is wearing. Elizabeth Hurley and Michael Gould (far right). Dines Allen E. Photos: Larry Schlager, Judie Schlager, Dr. Larry Norton, Jean Sharf, Fred Sharf Stacey Lucchino, Lawrence Lucchino, Karen Webster, Evelyn Lauder, Elizabeth Hurley Honoring New England Researchers After painting Boston pink, Evelyn Lauder and Elizabeth Hurley joined Dr. Larry Norton as Honorary Chairmen of the Hot Pink Dinner at The Four Seasons. The event, co-chaired by Sandy Krakoff and Karen Webster, honored the Foundation’s fourteen New England researchers.

The Hot Pink Dinner raised over $140,000 for BCRF. An auction prize, featuring a fabulous Red Sox package for four, donated by Red Sox President Larry Lucchino and his wife Stacey, along wth baseball gloves from Nokona and a $1,000 shopping spree at Saks, was so popu- Kensington Palace Prudential Center lar that it sold twice, raising a total of $16,000. In 2005, the Foundation The Estée Lauder Companies illumination initiative is in its sixth year. Prudential Center in Boston turned pink in October. awarded $3.2 million in grants to New England researchers. Kensington Palace, London Jeanette Wagner, Dr. Judah Folkman, Myra Biblowit

10 The Breast Cancer Research Foundation Winter Newsletter 2006 11

events PLAY FOR P.I.N.K. 2005: A YEAR IN THE PINK What do you get when you cross a gleaming new record with the color pink? Play for P.I.N.K.’s 2005 season! As the 2006 season is launching in Florida, we are thrilled to announce an unsurpassed number of participants, an expansion to over 100 tournaments in twelve states and a record-breaking amount of funds raised. ratt

On November 1st, Play for P.I.N.K.’s (PFP) board proudly presented The Breast Cancer ulie Skar J Research Foundation with a $1,700,000 check, bringing its total contributions to $8 mil-

lion! All of the clubs that held their first PFP events were met with resounding success. Photos: Kevin Lawler,Tisa Rabun, Cherri Divin, Evelyn Lauder, Heidi Sirota, Peter MacGill and Glenn Lowry Celso Gonzalez-Falla,Adam Weinberg Some examples: Colleton River Plantation, which raised over $40,000, while Stanton Joleen Speight, Jack Sharry Ridge brought in almost $20,000. The inaugural “Paint the Town Pink” walk in North Play for P.I.N.K.at Alpine Country Arlington, NJ contributed over $6,000. The next walk will be September 30, 2006. Photo exhibition by Evelyn Lauder Club in Alpine, NJ Contact Patty at www.pinkribbonwalk.com for information. Beauties and other New Work PFP’s contribution to BCRF funds five of the nation’s leading breast cancer researchers: Evelyn Lauder kicked off her newest photography exhibition Visit www.playforpink.org Robert Benezra, PhD, Teresa Gilewski, MD, Philip O. Livingston, MD, tour at the Pace/MacGill Gallery in NYC in November. The to find out about ongoing Electra D. Paskett, PhD and Michael Wigler, PhD. exhibition tour, made possible with generous underwriting by The Phoenix Companies, Inc., was a resounding success, with achievements, happenings, Upcoming Tournaments in Florida: how to get involved or to January 13 Boca Woods Tennis, January 14 Bear’s Paw, January 19 Terravita, January 23 Bear’s Paw, over $73,000 raised through exhibition sales. The tour January 24 The Polo Club, January 25 The Loxahatchee Club, February 2 Eastpointe; Palmira, February 6 Boca continues: Arthur Ross Gallery, University of Pennsylvania, make a donation. West, February 7 Gleneagles; Aberdeen, February 9 Ballen Isles, February 9 Boca West, February 14 Turnberry Golf & Tennis; Ballen Isles, February 16 Broken Sound, February 19 Shadow Wood, February 21 Atlantis, Philadelphia, from June 15 - July 2006; the Baldwin Gallery in February 22 Trump International, February 28 Boca Woods Golf, February 28 St. Andrews, March 9 Sailfish Point, Aspen, Colorado in summer 2006; and the John Berggruen March 11 Dressage Challenge, April 1 The Links at Boynton Beach, April 2 Bocaire, April 4 Delaire, April 6 CC of Naples, April 18 Sea Pines Gallery in San Francisco, California in 2006. Leonard Lauder and Ingrid Sischy Bobbi Brown

PARTY IN PINK

BCRF's Junior Host Committee held the “Party In Pink” in November at Loft 11 in New York City. Over 300 young professionals showed up to dance to music by DJ Vibe and Fabiola Beracasa and Patricia Sorenson raise awareness among the group, which will Play for PINK at Bocaire Country Club in Boca Raton, FL The Play for P.I.N.K.board presented a $1.7 million check to Evelyn Lauder benefit from all of the current advances in breast cancer research. Support from Cambria, Coach, Future Brands LLC, Glamour, Goldman

Sachs, and Mr. and Mrs. Saratoga Randall King made the Elizabeth Valando, Carol Farmer, Debby Oxley

w event a success, raising On August 19th, 160 guests gathered under the tent at more than $30,000. The Reading Room for the 3rd annual luncheon in

yson Sudo Saratoga Springs, NY. Lunch was followed by an Al information discussion with Dr. Larry Norton entitled

Photo: “Rapid Advances in Our Understanding and Management Play for P.I.N.K. participants at the Shore and Country Club, East Norwalk, CT Junior Committee Chairman Funa Maduka of Breast Cancer.” The event raised over $114,000.

12 The Breast Cancer Research Foundation Winter Newsletter 2006 13

thank you What could be sweeter than a cure? 's limited edition pink ® people helping people Mints is raising more than $100,000 for BCRF. Pictured: Miranda Moss, a breast cancer survivor who created the Frango art work, Elizabeth Hurley, Myra Biblowit, Evelyn Lauder, Frank Guzzetta, Dr. Funmi Olopade.

Barbara Zinn Moore hands Myra Biblowit a check for $25,000 from Lord & Taylor’s 1 Mother’s Day 2005 promotion.

Danskin Women’s Triathlon For the 2nd year, BCRF was the official charity of Danskin Women's Triathlon Series. Over 20,000 women participated, raising over $146,000 for BCRF. The series celebrated its 100th race this year. 2

BCRF salutes all individuals and companies large and Barbara Livingston small, who commit timeless hours to generate money for research. There are many people to thank - every- one who bought a pink product, or a Love Cures card, the brave men and women of our Survivor Circle The first ever pink plane: During October, Song‚ Delta Air Partnership program, friends at Wilson, D'Arrigo Lines’ low-fare service, raised $75,000 for BCRF through Brothers, Boscov's, Bon-Ton, Fortunoff', Prides Corner on-board donations from passengers, proceeds from non- Farms, Ouidad, Burberry, For Eyes, Coach, Ann Taylor, alcoholic “pink beverages” sold on-board and proceeds from Aveda and Carolee, the Dashing Divas, all the Bunco the sale of “pink products” in local Song markets. From for Breast Cancer players, quilters from Quilters At January through Sea. Many are included in this newsletter, yet the list March, you can 3 goes on and on. Every dollar is one dollar closer to a donate your cure. Here are snapshots of various efforts. Delta SkyMiles to BCRF by logging onto 6 delta.com/sky- wish. See page Fauchon’s October 16 for details. windows on Park Ave. in NYC

Carmen Marc Valvo donated $10,000 from the trunk show at Bergdorf Goodman, NYC. Pictured: Carmen Marc Valvo, Deborah Krulewitch, Jeanette Wagner. 5 4 Holt Renfrew hosted the launch of BCRF’s first Canadian effort including selling the exclusive pink cash- 1: Rich Lehrer, Dan Brestle,William Lauder, Roger Caracappa at the Estée Lauder Third Annual "Play for Pink" Long Island Golf Classic. Through the generosity and mere T-shirt that support of many, this year turned out to be the most successful yet, raising over $74,000. 2: “Call Me Larry” from Find a Cure Stable is named for Dr. Larry Norton. Elizabeth Hurley is This horse, owned by Suzie and Doc O’Cain, will be running for BCRF. 3: Beth Carr, Erin McGraw and Elizabeth White of Georgetown Visitation Preparatory School in wearing. Holt The international hit show MAMMA Washington, DC raised money by creating and selling "exam goodie bags" to parents before exam week. This is one example of the “Think Pink” club’s efforts. The Renfrew donated $50,000.00 (CAN) and MIA! has been supporting BCRF for students donated $10,000, doubling previous years. 4: On October 5th, the Estée Lauder Northeast Sales Team held its fifth annual walk to benefit BCRF. The 80 American Express donated $15.00 for years by selling the Rock Chick member Sales Team made their way along Boston’s historic waterfront and raised over $22,000. 5: Lehigh Valley Miata Owners Club’s first Drive to Survive tour every cashmere tee purchased on an Supremo T-shirt throughout the topped $8,000 and they only had half the cars they wanted. Pictured: Louis DePaul, Pat Rizzotto, Rich Young, Bob Young, Jean Rymon, Brent Rymon, Sharon DePaul. Amex Card. world. To date the sales have 6: For the 3rd year, Debbie Adelman-Snyder arranged a “Pink Ribbon Walk” in Holmdel, NJ, and hosted a party in NYC in celebration of two years of her continued good generated over $300,000. health. Debbie has raised over $40,000 for BCRF.

14 The Breast Cancer Research Foundation Winter Newsletter 2006 15

your pink calendar... February 13th The Hot Pink Symposium and Luncheon, March 11th Flagler Museum, Palm Beach, FL International Quadrille Team Challenge, Wellington, FL February 14th Evelyn Lauder keynote speaker at the Jewish Federation of Dallas Women's March 13th Luncheon, Dallas, TX 9th Annual Housewares Charity Foundation Dinner, February 26th Sheraton Hotel, Chicago, IL Polo and Think Pink” Luncheon, Windsor, Vero Beach, FL

BCRF STAFF President Mary Briggs Kathleen Hirdt Myra Biblowit Executive Assistant/Office Associate, Special Events [email protected] Manager [email protected] April 10th 646.497.2601 [email protected] 646.497.2606 646.497.2613 The Very Hot Pink Party, Deputy Director Anne MacGillivray Margaret Mastrianni Anna DeLuca Director, Special Events The Waldorf=Astoria, NYC [email protected] Consultant for Public Relations [email protected] 646.497.2604 [email protected] 646.497.2602 This year Sir Elton John is bringing 646.497.2609 Bibi Ali Kara Oppenheim Tony Bennett. Receptionist Carol Edwards Associate, Marketing [email protected] Database Administrator [email protected] 646.497.2600 [email protected] 646.497.2616 646.497.2607 Patricia Altman Jamie Rice Senior Manager, PSA and Robbie Finke Coordinator, Special Events Internet Director, Marketing and [email protected] [email protected] Corporate Sponsorships 646.497.2622 646.497.2603 [email protected] 646.497.2614 Claire Spoors Marci Brenholz Intern Assistant Manager, Stephanie Hamburger [email protected] Development Activities Director, Play for P.I.N.K. 646.497.2608 [email protected] Assistant Director, 646.497.2612 Special Events [email protected] 646.497.2605

The Breast Cancer Research Foundation NON-PROFIT ORG. 60 East 56th Street, 8th Floor New York, New York 10022 US POSTAGE PAID NEW YORK, NY SkyMiles Members Donate your Delta miles to BCRF PERMIT NO. 2405 BCRF has been named Delta's Charity of First Quarter 2006.There is a 5,000-mile minimum and Delta will add one mile for every 5 miles you donate. Information can be found at delta.com/skywish. Every mile helps. The Breast BCRF Contact Info: Cancer Phone: 646.497.2600 Research

Toll-Free: 866.FIND.A.CURE Foundation TM email: [email protected] www.bcrfcure.org ADDRESS SERVICE REQUESTED