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Home , Ellington (crater), Hassan Nasir, Infanta Blanca of Spain, Jacobsen syndrome, Karsh (crater), Marek Sanak

THURSDAY, FEBRUARY 27 AND FRIDAY, FEBRUARY 28

Thursday, February 27 3:45 Air Force Kevin M. White, MD Military Program 4:00 Army 0001 28 th Annual Harold S. Nelson Military Allergy/ Michael R. Nelson, MD PhD FAAAAI Symposium 4:15 Navy 7:20 am to 5:00 pm Michael R. Kaplan, DO FAAAAI Convention Center, Upper Level, Room 3 4:30 Business Meeting and Award Presentations Pre-registration and ticket required. No fee for approved and Upon completion of this session, participants should be able to: Discuss the approach to identifying allergic skin disorders in the military environment and the role of biopsy in the registered military members. $60 fee for non-military members. diagnosis and management; Identify the differential diagnosis of chronic urticaria and Continental breakfast and box lunch included. explain the diagnostic approach; Discuss the application of novel therapy in the treatment Credit: 7.00 CME / 8.00 CE of chronic urticaria. Moderator: Kimberly S. Johnson, MD Kimberly S. Johnson, MD Fellows-In-Training and New Allergist/Immunologist 8:00 Morning Address: Dermatology for the Military Allergist Assembly Joint Reception Timothy Straight, MD PhD 7:00 to 8:00 pm 9:00 Break Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Fellow Original Research Reception is open to current Chrysalis participants, FITs and NAIA 9:30 Safety of Cluster Immunotherapy During Refill Dosing members. Tiffany J. Owens, MD 9:50 Demographics and Retention Patterns for 1999-2011 U.S. Air Friday, February 28 Force Allergy Graduates Fellows-in-Training Program Michelle Bandino, MD 10:10 Serologic Specific IgE (sIgE) Testing in a Closed Healthcare 1011 FIT Symposium System 7:00 am to 2:00 pm Daniel A. Steigelman, MD Marriott North Tower, Lobby Level, San Diego Ballroom Salon B 10:30 Safety and Efficacy of a 12-Week Maintenance Interval in Patients Pre-registration and ticket required. No fee. Continental breakfast and Treated With Imported Fire Ant Immunotherapy box lunch included. Karla E. Adams, MD Credit: No CME / No CE Staff Original Research 7:00 Networking Breakfast 10:50 Vitamin D Supplementation Improve Urticaria Symptoms in Adult 8:00 Introductions Chronic Urticaria Taylor A. Banks, MD Tadech Boonpiyathad, MD Mary Beth Fasano, MD FAAAAI 11:10 Increased Respiratory Illness and Transient Immune Alterations 8:05 Networking Organizations Seen with Multiple Vaccinations Administered in a Stressful 8:15 American Board of Allergy and Immunology Environment Stephen I. Wasserman, MD FAAAAI Rachel Umi Lee, MD FAAAAI 8:20 Allergy Immunotherapy: The Basics 11:30 Lunch and Bruton Lecture: Treatment Options for Refractory Michael R. Nelson, MD PhD FAAAAI Urticaria 8:50 Immunotherapy Extracts A. Khan, MD FAAAAI Robert G. Hamilton, PhD D.ABMLI FAAAAI Fellow Case Reports 9:20 Break 1:00 Selective IgM Deficiency Presenting as Cryptogenic Organizing 9:35 Welcome from the AAAAI President Linda Cox, MD FAAAAI Cory A. Lundberg, DO 9:45 Immunotherapy: New and Emerging Issues 1:20 A Devastating Outcome in Undiagnosed X-Linked Linda Cox, MD FAAAAI Agammaglobulinemia: A Call for Earlier Screening 10:15 Immunomodulation with Immunotherapy Karen Elizabeth Bruner, MD Joann C. Blessing-Moore, MD FAAAAI 1:40 Intractable Burkholderia Vietnamiensis and Hemophagocytic 10:45 Pearls and Pitfalls of Diagnostic Testing Lymphohistiocytosis in Homozygous Interleukin-12 Receptor Michael S. Blaiss, MD FAAAAI Beta-1 Deficiency 11:15 Venom Immunotherapy Ki Lee Milligan, MD David B.K. Golden, MD FAAAAI 2:00 Break 11:45 Difficult AIT Cases 2:30 Vaccine Healthcare Center Update David A. Khan, MD FAAAAI Limone C. Collins Jr., MD 12:15 Networking Lunch 3:00 Military Aeroallergen Extract Laboratory Updates 1:00 AIT Prescription Workshop Susan E. Kosisky, BS MHA Upon completion of this session, participants should be able to: Describe the pathophysi- Consultants to the Surgeons General Updates: ology, initial evaluation and management of patients with to aeroallergens and/or 3:30 VHA Allergy Committee venoms; Identify recent advances in the field of immunotherapy, including mechanisms of immunomodulation; Discuss current and emerging treatment modalities and adjuncts in Joseph S. Yusin, MD FAAAAI the management of aeroallergen and venom allergic patients.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 25 FRIDAY, FEBRUARY 28

Allied Health Course 1101D Di!erentiating From COPD: Why is This So Hard? 1101 Advanced Practice Course Marriott North Tower, Lobby Level, Atlanta & Chicago 8:00 am to 12:30 pm Edward O. Corazalla, MS RPFT Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Karen L. Gregory, DNP APRN-BC RRT AE-C Pre-registration and ticket required. No fee. Upon completion of this session, participants should be able to identify differences and Credit: 4.50 CME / 5.40 CE similarities in patients with asthma vs. COPD. Moderators: Nina A. Zimmermann, MSN RN ANP-BC AE-C Debra A. Sedlak, MSN CPNP Clinical Research Workshop 8:00 Introduction Debra A. Sedlak, MSN CPNP 1102 The Anatomy of the Clinical Trial Agreement 8:15 Patients’ Attitudes and Beliefs About Complementary and 8:00 to 9:15 am Alternative Use for Asthma Self-Management Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Maureen George, PhD RN AE-C FAAN Credit: 1.25 CME / 1.50 CE 9:00 Bronchial Thermoplasty for the Treatment of Severe Asthma Moderator: Christopher Chang, MD PhD FAAAAI Mario Castro, MD MPH The Anatomy of the Clinical Trial Agreement and Negotiating a 9:45 Question & Answer Profitable Budget Cheryl Koff Bernstein, RN BSN CCRC 10:00 Vitamin D: Sunlight at the End of the Tunnel Upon completion of this session, participants should be able to: Identify and discuss the Nicolette De Jong, PhD language used in reciprocal or crossed indemnification and offer alternative indemnifica- 10:45 : New Therapies on the Horizon tion language during contract negotiations; Identify and discuss important sections of the Beth D. Strong, RN CCRC contract such as liability insurance, language used to describe adherence to the protocol, 11:30 Managing Atopic : Itching the Night Away! payment, study termination and offer alternative language; Discuss successful methods and techniques used during contract and budget negotiations with the sponsor. Karol G. Timmons, RN MS CPNP 12:15 Question & Answer Chrysalis Project Upon completion of this session, participants should be able to: Evaluate how patients' health beliefs impact asthma self-management; Identify asthma patients who may 1111 2014 Chrysalis Project Program benefit from alternative treatments such as broncial thermoplasty and Vitamin D therapy; 7:30 am to 2:00 pm Define new and appropriate treatment strategies for common food allergies and atopic dermatitis. Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Pre-registration and ticket required. No fee. Continental breakfast and Allied Health Advanced Practice Course Breakout box lunch included. Credit: No CME / No CE Sessions 7:30 Breakfast 12:30 to 2:00 pm 8:00 Welcome Separate pre-registration, ticket and fee from the 1101 Advanced Thomas A. Fleisher, MD FAAAAI Practice Course. Pre-registration and ticket required. Fee: $20. Kimberly A. Risma, MD PhD FAAAAI Box lunch included. Sessions and meals are limited to registered 8:05 Welcome from the AAAAI President attendees. Linda Cox, MD FAAAAI Credit: 1.50 CME / 1.80 CE 8:15 Food Allergy 1101A Cough/Chronic Cough A. Wesley Burks, MD FAAAAI Marriott North Tower, Lobby Level, Marriott Hall Salon 5 8:45 Eosinophilic Disorders Nina A. Zimmermann, MSN RN ANP-BC AE-C Paneez Khoury, MD Jeanette L. Arnold, MSN RN C-FNP 9:15 Immunodeficiency Upon completion of this session, participants should be able to discuss the diagnostic evaluation and therapeutic options to treat chronic cough. Kathleen E. Sullivan, MD PhD FAAAAI 9:45 Break 1101B Is This ? 10:00 Asthma Marriott North Tower, Lobby Level, Marriott Hall Salon 6 Rohit Katial, MD FAAAAI Gabriel Ortiz, MPAS PA-C DFAAPA 10:30 Atopic Dermatitis Vivian P. Hernandez-Trujillo, MD FAAAAI Donald Y.M. Leung, MD PhD FAAAAI Upon completion of this session, participants should be able to describe anaphylaxis and the initiation of appropriate treatment. 11:00 Academic Career Paths Kimberly A. Risma, MD PhD FAAAAI 1101C Opening Pandora’s Box: Asking the Right 11:20 Industry Career Paths Questions Daniel C. Adelman, MD FAAAAI Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 11:40 Private Practice Career Paths David Wayne Unkle, MSN APN FCCM Adina Kay Knight, MD FAAAAI Anthony J. Ricketti, MD FACAI FCCP 12:00 Chrysalis Project Program Luncheon with FIT Mentors Upon completion of this session, participants should be able to discuss strategies for interpreting information given by our patients.

26 Allied Health Session ticket required fee required included in the Virtual Annual Meeting FRIDAY, FEBRUARY 28

Program Directors Course Course 1112 How to Develop and Maintain Excellence in 1202 NIAID: Epigenetics in Asthma and Allergy: Basic Allergy/Immunology Fellowships: Boot Camp for Concepts and Recent Advances Program Directors and Clinical Faculty 9:00 am to 12:00 pm 8:15 am to 12:00 pm Convention Center, Upper Level, Room 11AB Marriott North Tower, Lobby Level, San Diego Ballroom Salon A Credit: 2.75 CME / 3.30 CE Pre-registration and ticket required. No fee. Continental breakfast Moderator: Alkis Togias, MD FAAAAI included. 9:00 Epigenetics: Basic Concepts Credit: No CME / No CE Bing Ren, PhD Moderator: Asriani M. Chiu, MD FAAAAI 9:25 Asthma and Allergy Epigenetics: What Have We Learned So Far? 8:15 Continental Breakfast David A. Schwartz, MD 8:45 The ABC’s of Post-Graduate Medical Education (AAAAI, ABAI, 9:50 Environmental Influences on the Epigenome ACGME) and Beyond Rachel L. Miller, MD FAAAAI Mary Beth Fasano, MD FAAAAI 10:15 Break 9:15 The Nuts and Bolts of Building an A/I Fellowship Program: 10:30 Epigenetic Regulation of the Immune System in Relation to Program Requirements in the Era of the Next Accreditation Allergy and Asthma System Kari C. Nadeau, MD PhD FAAAAI Jeffrey R. Stokes, MD FAAAAI 10:55 The Epithelial Cell Epigenome and its Relation to Asthma 9:45 Communications and Reference Tools: iPads, iPhones and Carole Ober, PhD PubMed 11:20 Epigenetic Regulation of Arachidonic Acid Metabolism and its Thanai Pongdee, MD FAAAAI Clinical Implications 10:15 Break Benjamin A. Raby, MD MPH 10:30 How to Use the Milestones for Effective Learner Assessment 11:45 Question & Answer Michael R. Nelson, MD PhD FAAAAI Upon completion of this session, participants should be able to: Describe the importance 11:00 Curriculum Design: Tips for Teaching Generation Y of epigenetic changes and their potential impact on our understanding and treatment of Fanny Silviu-Dan, MD FAAAAI allergic diseases and asthma; Identify specific cells and pathways relevant to allergy and asthma where epigenetic changes may influence disease. 11:30 Directing an A/I Fellowship Program: Ask the Expert Panel Discussion Course Mariana C. Castells, MD PhD FAAAAI Lawrence B. Schwartz, MD PhD FAAAAI 1203 Technology in the Clinical Practice Made Elizabeth A. Secord, MD FAAAAI Ridiculously Simple Upon completion of this session, participants should be able to: Enhance the teaching 9:00 am to 12:00 pm skills of upcoming, new and current allergy/immunology fellowship program directors and Convention Center, Mezzanine Level, Room 14AB associate program directors, core A/I fellowship faculty and community volunteer clinical faculty; Provide practical tips for developing and enhancing an A/I fellowship program in Credit: 3.00 CME / 3.40 CE the context of the next accreditation system; Support the development of allergy/immu- Moderator: Tao T. Le, MD MHS FAAAAI nology program directors, fellowship core faculty and community volunteer clinical faculty; 9:00 What Can Technology Do for Your Practice Improve the quality of allergy/immunology fellowship training. Tao T. Le, MD MHS FAAAAI 9:20 EHRs and the Meaningful Use of Life Course A. Sean McKnight, MD FAAAAI 1201 Advanced Course in Identi!cation 9:50 Practice Management Systems and Other Office Automation Tools 9:00 am to 12:00 pm Linda D. Green, MD FAAAAI Marriott North Tower, Lobby Level, Marriott Hall Salon 3 10:20 Break Pre-registration and ticket required. Fee: $125. 10:30 iPhones, iPads, Androids, Oh My! Credit: 3.00 CME / 3.60 CE Melinda M. Rathkopf, MD FAAAAI Moderator: Estelle Levetin, PhD FAAAAI 11:00 Social Media Tools for Marketing and Communications 9:00 Asteraceae Pollen Ves Dimov, MD Peter Van De Water, PhD 11:30 Making the Technology Work and Pay Off 9:30 Hands-On Instruction; Question & Answer David J. Shulan, MD FAAAAI 10:00 Betulaceae Pollen 11:50 Question & Answer Richard W. Weber, MD FAAAAI Upon completion of this session, participants should be able to: Describe EHRs, practice 10:30 Hands-On Instruction; Question & Answer management systems and office automation technologies appropriate for the clinical practice; Explain the role of mobile technologies in the practice; List web and social media 11:00 Other Triporate and Tricolporate Pollen tools for practice marketing and communications. Estelle Levetin, PhD FAAAAI 11:30 Hands-On Instruction; Question & Answer Upon completion of this session, participants should be able to: Differentiate pollen in the family and related tri-porate pollen types; Recognize difficult tricolporate pollen types; Differentiate asteraceae pollen other than .

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 27 FRIDAY, FEBRUARY 28

Course Course 1204 Endoscopic Evaluation and Management of 1206 Primary Immunode"ciency Diseases: What Do I Chronic Rhinosinusitis (Pre- and Post-Surgery) Do with My Patient? From Start to Finish Including Cultures 9:00 am to 12:00 pm 9:00 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Convention Center, Upper Level, Room 3 Credit: 2.75 CME / 3.30 CE Pre-registration and ticket required. No fee. Moderator: Lisa J. Kobrynski, MD MPH FAAAAI Credit: 3.00 CME / 3.40 CE 9:00 Who Needs Evaluation for Immunodeficiency? Moderator: Anju T. Peters, MD FAAAAI M. Teresa De La Morena, MD 9:00 Anatomy of the Sinuses 9:25 Assessing Innate and Adaptive Humoral Immunity Todd T. Kingdom, MD Francisco A. Bonilla, MD PhD FAAAAI 9:20 Radiology of the Sinuses 9:50 Assessing Innate and Adaptive Cellular Immunity S. James Zinreich, MD I. Celine Hanson, MD FAAAAI 10:00 Endoscopic Evaluation of the Sinuses Including Cultures: Video 10:15 Question & Answer and Lecture 10:35 Break Wellington S. Tichenor, MD FAAAAI 10:50 Therapies for Innate and Adaptive Humoral Immunodeficiency 10:20 Break Vincent R. Bonagura, MD FAAAAI 10:30 Surgical Evaluation 11:15 Therapies for Innate and Adaptive Cellular Immunodeficiency Robert C. Kern, MD Mark Ballow, MD FAAAAI 10:50 Endoscopic Evaluation of the Sinuses: Post-Surgical 11:40 Question & Answer Wellington S. Tichenor, MD FAAAAI Upon completion of this session, participants should be able to: Describe a general ap- 11:10 Case Management Studies: Question & Answer proach to a patient with recurrent infections or other presentation consistent with PID; Daniel L. Hamilos, MD Discuss the stepwise approach to the diagnosis of PID and how to apply advanced and specialized tests, possibly in conjunction with guidance from a tertiary provider; List Upon completion of this session, participants should be able to: Describe the anatomy of the different modalities available for therapy, general principles of their application and the and identify pathology on CT scan; Recall indications for surgery resources for guidance in unusual or complex situations. and complications of surgery; Perform endoscopy in patients with CRS as well as cultures of the middle meatus and/or sinuses and review management of complicated . Course Course 1207 1205 Di!cult Cases (Part 1) 9:00 am to 12:00 pm 9:00 am to 12:00 pm Convention Center, Upper Level, Ballroom 6DE Convention Center, Mezzanine Level, Room 15AB Credit: 2.75 CME / 3.30 CE Pre-registration and ticket required. No fee. Moderator: Rebecca S. Gruchalla, MD PhD FAAAAI Credit: 2.75 CME / 3.20 CE 9:00 Symptoms and Skin Testing for Type I Chemotherapy Drug Moderators: David W. Hauswirth, MD FAAAAI Hypersensitivity Joyce E. Yu, MD David E. Sloane, MD 9:00 Hypereosinophilic Disorders (Not EoE) 9:50 Break Amy D. Klion, MD 10:05 Patch Testing in Drug Allergy Princess U. Ogbogu, MD FAAAAI Antonino G. Romano, MD 9:35 Itching Without Rash 10:55 Antibiotic Skin Testing Cem Akin, MD PhD FAAAAI Anahita F. Dioun, MD FAAAAI Gerald B. Lee, MD 11:45 Question & Answer 10:10 Break Upon completion of this session, participants should be able to: List the symptoms of Type 10:30 Peri-Operative Anaphylaxis I drug hypersensitivity reactions; Identify symptoms of Type IV drug hypersensitivity reac- tions; Describe diagnostic tools for Type I and Type IV drug hypersensitivity reactions. Phillip L. Lieberman, MD FAAAAI Joel M. Hartman, MD 11:05 What the Allergist/Immunologist Sees That is Not Allergy Dennis K. Ledford, MD FAAAAI Eugene M. Choo, MD FAAAAI 11:40 Question & Answer Upon completion of this session, participants should be able to discuss diagnostic and clinical management challenges encountered in allergy, asthma and immunology practice.

28 Allied Health Session ticket required fee required included in the Virtual Annual Meeting FRIDAY, FEBRUARY 28

Course 1209A/D Hands-On Workshop: Allergy Skin Testing Convention Center, Upper Level, Room 32AB 1208 Dermatology for the Allergist: Diagnosis and Credit: 1.00 CME / 1.20 CE Therapeutics Boot Camp Peter S. Creticos, MD FAAAAI 9:00 am to 12:00 pm Jay A. Lieberman, MD Convention Center, Mezzanine Level, Room 16AB John Oppenheimer, MD FAAAAI Pre-registration and ticket required. No fee. Anita Trikha, MD Credit: 3.00 CME / 3.40 CE Upon completion of this session, participants should be able to: Compare the different Moderator: Lynda C. Schneider, MD FAAAAI devices and other equipment and their characteristics; Explain the importance of stan- 9:00 Common Dermatologic Diseases with Mimics and Crossovers in dardized allergen extracts for the test result; Demonstrate the importance of standardized testing technique and its control by proficiency testing. Allergy: Overview from a Dermatology Perspective Peter A. Lio, MD 1209B/C Coding and Regulatory Issues Related to 9:30 Therapies for Dermatitis Allergy Diagnosis and Treatment Lawrence F. Eichenfield, MD Convention Center, Upper Level, Room 33AB 10:00 Question & Answer Credit: 1.00 CME / 1.20 CE 10:10 Break Donald W. Aaronson, MD FAAAAI 10:20 Video Demonstration: Biopsies, Scrapings and Patent Testing David A. Brown, MD Lawrence F. Eichenfield, MD Gary N. Gross, MD FAAAAI 11:00 Hands-On Learning Upon completion of this session, participants should be able to apply adequately the cod- ing, documentation and regulatory guidelines for immunotherapy. Lawrence F. Eichenfield, MD Luz S. Fonacier, MD FAAAAI Course Peter A. Lio, MD Upon completion of this session, participants should be able to: Discuss common diag- 1210 Principles of Healthy Homes: What to Look for nostic tests applicable to eczemas; Outline basic skin care for allergic skin diseases and avoidance of pitfalls. and How to Help Your Patients or Evaluation and Mitigation Course 9:00 am to 12:00 pm 1209 : The Nuts and the Bolts Convention Center, Upper Level, Room 33C Pre-registration and ticket required. No fee. (Part 1) Credit: 2.75 CME / 3.30 CE 9:00 to 10:00 am Moderator: Jay M. Portnoy, MD FAAAAI Convention Center, Upper Level, Room 30CDE 9:00 The Indoor Biome and Healthy Housing Pre-registration and ticket required. No fee. Christina E. Ciaccio, MD FAAAAI Credit: 1.00 CME / 1.20 CE 9:30 How to Evaluate a Problem Home: Tools You Can Use Moderator: Matthew A. Rank, MD FAAAAI Kevin Kennedy, MPH CIEC 9:00 Advances in Allergy Diagnostic Testing: Component Resolved 10:00 Break Diagnosis to Identify Specific Joerg R. Kleine-Tebbe, MD FAAAAI 10:15 Working With Patients: Taking an Environmental Healthy History James L. Sublett, MD FAAAAI 9:30 Food Immunotherapy: Baked, Shaken or Stirred: Is it Ready to be Served? 10:45 Remediating and Maintaining a Healthy Home Robert A. Wood, MD FAAAAI Paul J. Dowling, MD FAAAAI Upon completion of this session, participants should be able to: Discuss how diagnosis 11:15 What Works, What Doesn’t and What Needs to be Done might improve with in vitro techniques to come; Discuss clinical readiness of food im- Wanda Phipatanakul, MD MS FAAAAI munotherapy. 11:45 Question & Answer Upon completion of this session, participants should be able to: Identify the principles of

Course Breakout Sessions healthy homes and the relative importance of each; Identify the basic steps in taking an Attendees will rotate between the following two workshops. environmental history about a patient’s home environment; Describe the essential steps to Pre-registration and ticket required. Fee: $25. Sessions are limited to assess home environmental hazards and conditions and mitigation. registered attendees. 10:00 am to 12:00 pm

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 29 FRIDAY, FEBRUARY 28

Allied Health Workshop Allied Health Workshop 1301 Psychosocial Well-Being: Living with Food 1501 Ask the Expert: Roundtable Discussion Allergies 12:30 to 1:30 pm 9:30 to 10:45 am Marriott North Tower, Lobby Level, Presidio Rooms 1 & 2 Marriott North Tower, Lobby Level, Marriott Hall Salon 5 Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 1.25 CME / 1.50 CE Credit: 1.00 CME / 1.20 CE Panelists: Moderator: John D. Milewski, Med. Admin. Jennifer M. Darr, MSW LCSW Joan E. Hawkins Melissa T. Korenblat-Hanin, ACSW LCSW Teresa Thompson, CPC CMSCS CCC Upon completion of this session, participants should be able to: Describe the psychoso- 11:30 Question & Answer cial dynamics of living with food allergies: challenges, emotions and accomplishments; Upon completion of this session, participants should be able to: Identify coding and ICD10 Discuss approaches that build and enhance stability, security and sensibility using chal- challenges in 2014; Discuss best practices for motivating employees; Identify how to lenging case scenarios; Identify successful resources for assisting the food allergic patient assess your clinical practices. and family. Program Directors’ Business Meeting Allied Health Workshop 2:00 to 4:00 pm 1302 The Asthma Action Plan: Use of Simulation to Marriott North Tower, Lobby Level, San Diego Ballroom Salon A Teach and Reinforce All Program Directors and Co-Directors are invited to attend this business meeting. 9:30 to 10:45 am Marriott North Tower, Lobby Level, Atlanta & Chicago Credit: 1.25 CME / 1.50 CE Course Moderator: Maureen George, PhD RN AE-C FAAN 1601 Advanced Course in Fungal Spore Identi!cation Using Simulation to Improve Patient Education About the Asthma 2:00 to 5:00 pm Action Plan Marriott North Tower, Lobby Level, Marriott Hall Salon 3 Anne E. Borgmeyer, MSN RN CPNP AE-C Pre-registration and ticket required. Fee: $125. Upon completion of this session, participants should be able to: Describe principles of Credit: 3.00 CME / 3.60 CE patient and family-focused education; Review the use of simulation to teach patient Moderator: Estelle Levetin, PhD FAAAAI communication strategies to providers; List the key principles of the Asthma Action Plan to improve self-management and asthma control. 2:00 Basidiospore Identification Estelle Levetin, PhD FAAAAI Allied Health Workshop 2:30 Hands-On Instruction; Question & Answer 3:00 Ascospore Identification 1401 Developing and Maintaining a Successful W. Elliott Horner, PhD LEED AP FAAAAI Research Center: Secrets of a Trade 3:30 Hands-On Instruction; Question & Answer 11:00 am to 12:15 pm 4:00 Challenging Spore Types Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 James Scott, PhD Credit: 1.25 CME / 1.50 CE 4:30 Hands-On Instruction; Question & Answer Moderator: Craig F. LaForce, MD FAAAAI Upon completion of this session, participants should be able to: Interpret common basid- Cheryl Koff Bernstein, RN BSN CCRC iospores; Interpret common ascospores; Describe Fusarium, Penicillium/Aspergillus and David I. Bernstein, MD FAAAAI other difficult spore types. Upon completion of this session, participants should be able to: Discuss the infrastruc- ture necessary to establish a successful and productive research center; Discuss the challenges of maintaining a successful research center while competing in global clinical trials; Identify strategies for promoting your research center and enhancing your chances for clinical trial selection.

Allied Health Workshop 1402 The Food Allergy Spectrum: Not Just , Eggs and Milk 11:00 am to 12:15 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Panelists: Pinkus Goldberg, MD FAAAAI Karen S. Rance, DNP RN CPNP AE-C Upon completion of this session, participants should be able to: Identify an evidence- based approach to managing food allergy patients with less common allergens; Discuss how to screen for possible sensitivity to food additives and preservatives; Describe a management approach for patients with multiple food allergies.

30 Allied Health Session ticket required fee required included in the Virtual Annual Meeting FRIDAY, FEBRUARY 28

Course Course 1602 NIAID: Recent Advances in Biomarkers of Allergy 1604 Di!cult Cases (Part 2) and Asthma 2:00 to 5:00 pm 2:00 to 5:00 pm Convention Center, Mezzanine Level, Room 15AB Convention Center, Upper Level, Room 11AB Pre-registration and ticket required. No fee. Credit: 2.75 CME / 3.30 CE Credit: 2.75 CME / 3.20 CE Moderator: Marshall Plaut, MD FAAAAI Moderators: Jason W. Caldwell, DO FAAAAI 2:00 Allergen Challenge as a Biomarker of Disease Severity and of the Michael H. Land, MD FAAAAI Effects of Treatment 2:00 COPD vs. Asthma Stephen R. Durham, MA MD FRCP William W. Busse, MD FAAAAI 2:25 Transcriptomic Changes After Allergen Exposure Matthew C. Bell, MD Sunil K. Ahuja, MD 2:35 Implant Allergy 2:50 Basophil Activation as a Predictor of Food Allergen Severity Luz S. Fonacier, MD FAAAAI Alexandra F. Santos, MD MSc Haejin Kim, MD 3:15 Break 3:10 Break 3:30 Basophil Activation as a Biomarker of Food Allergy and Asthma 3:30 New Immune Deficiencies Wayne G. Shreffler, MD PhD FAAAAI Gulbu Uzel, MD Monica G. Lawrence, MD 3:55 T Regulatory Cells as Markers of Allergen Immunotherapy Andrew D. Luster, MD PhD 4:05 Mystery Rashes Lisa A. Beck, MD FAAAAI 4:20 CD27 Effector Cell Depletion During Allergen Immunotherapy Anne Marie Singh, MD Erik R. Wambre, PhD 4:40 Question & Answer 4:45 Question & Answer Upon completion of this session, participants should be able to discuss diagnostic and Upon completion of this session, participants should be able to: Explain how mediators clinical management challenges encountered in allergy, asthma and immunology practice. produced following allergen challenge predict the status of allergic diseases; Describe the relationship of successful allergen immunotherapy to effects on circulating T cell subsets and responses; Appreciate the value of measuring peripheral blood basophil Course activation in allergic diseases and asthma. 1605 Mast Cell Activation Syndromes: From Course Anaphylaxis to 2:00 to 5:00 pm 1603 Finding a Job and Getting Started in Practice Convention Center, Upper Level, Room 6A 2:00 to 5:00 pm Credit: 2.75 CME / 3.30 CE Convention Center, Upper Level, Room 2 Moderator: Luis Escribano, MD PhD FAAAAI Credit: 3.00 CME / 3.40 CE 2:00 Anaphylaxis to Hymenoptera Venom Moderator: Tao T. Le, MD MHS FAAAAI Patrizia Bonadonna, MD PhD 2:00 Overview and Introductions 2:30 Mastocytosis: Role of Tryptase and C-Kit Tao T. Le, MD MHS FAAAAI Cem Akin, MD PhD FAAAAI 2:05 Finding a Job and Negotiating the Agreement 3:00 Break Tao T. Le, MD MHS FAAAAI 3:15 Non-Clonal Mast Cell Activation Syndrome 2:40 Getting Licensed and Transitioning into Practice Mariana C. Castells, MD PhD FAAAAI Brian A. Smart, MD FAAAAI 3:45 When and How to Perform a Bone Marrow Study in MCAS: 2:55 Break Practical Recommendations 3:05 Secrets of an Efficient Allergy Practice Luis Escribano, MD PhD FAAAAI David L. Patterson, MD MS MBA FAAAAI 4:15 Idiopathic Anaphylaxis 3:40 Practice Finances 101 Paul A. Greenberger, MD FAAAAI Marshall P. Grodofsky, MD FAAAAI 4:45 Question & Answer 4:15 Marketing Your Practice and Referral Development Upon completion of this session, participants should be able to: Discuss the symptoms Stanley M. Fineman, MD MBA FAAAAI and presentation of mast cell activation syndromes (MCAS); Outline the role of tryptase 4:50 Question & Answer and c-kit mutations in MCAS; Describe management options for MCAS. Upon completion of this session, participants should be able to: Outline how to identify and join the right practice opportunity; Discuss the fundamentals of office management; Identify strategies for marketing a practice and building a patient base.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 31 FRIDAY, FEBRUARY 28

Course Upon completion of this session, participants should be able to: Discuss ethnic and geographical differences in PID prevalence and clinical presentation around the world; 1606 Review of Systemic Autoimmune Disease and Discuss international vaccine programs and challenges posed for the PID community; Treatment Review clinical scenarios of PID management in different settings around the world. 2:00 to 5:00 pm Course Convention Center, Upper Level, Ballroom 6B Credit: 3.00 CME / 3.60 CE 1608 NIEHS: Exposure to Indoor Allergens and Moderator: Arnold I. Levinson, MD FAAAAI Endotoxin in Relation to Allergic Disease: Results 2:00 Update on Laboratory Diagnosis of Systemic Autoimmune from NHANES 2005-2006 Disease 2:00 to 5:00 pm David P. Huston, MD FAAAAI Convention Center, Upper Level, Ballroom 6DE 2:30 ACR Updated Recommendations for Disease-Modifying Credit: 2.75 CME / 3.20 CE Antirheumatic and Biologic Agents in the Treatment of RA Moderators: Paivi M. Salo, PhD Arthur Kavanaugh, MD FAAAAI Darryl C. Zeldin, MD 3:00 Question & Answer 2:00 Overview of the NHANES 2005-2006 Allergy Component 3:15 The Spectrum of Vasculitis: New Insights into Pathogenesis and Darryl C. Zeldin, MD Treatment 2:20 Multiplexed Allergen Measurements: New Standards and Richard Keating, MD Performance Parameters 3:45 New Treatment Modalities for Lupus Eva-Maria King, PhD Mary Anne Dooley, MD 2:40 NHANES 2005-2006: Getting to Grips with the Big Data 4:15 Susceptibility to Infections in Autoimmune Disease: Is it the Agustin Calatroni, MA MS Disease or the Treatment? 3:00 Break John J. Cush, MD 3:20 IgE Sensitization and Current Allergen Exposure: Implications for 4:45 Question & Answer Environmental Intervention Upon completion of this session, participants should be able to: Interpret screening and Herman Mitchell, PhD follow-up reflex testing in the diagnosis of autoimmune disease; Review the latest treat- ment guidelines for rheumatoid arthritis; Describe the organ systems lupus can affect and 3:40 Environmental Exposures and Allergy Symptoms the downstream sequelae of complement activation. Paivi M. Salo, PhD 4:00 Which Combinations of IgE Clusters and Exposures Have the Course Greatest Impact on Asthma? Peter J. Gergen, MD MPH 1607 Primary Immune De!ciency: A Global Perspective 4:20 Endotoxin Exposure Assessment and 2:00 to 5:00 pm Peter S. Thorne, PhD Convention Center, Upper Level, Ballroom 6CF Credit: 3.00 CME / 3.40 CE 4:40 Question & Answer Moderator: Motohiro Ebisawa, MD PhD FAAAAI Upon completion of this session, participants should be able to: Interpret the role that allergen/endotoxin exposures and allergic sensitization play in allergic diseases; Apply 2:00 An Overview of Primary Immunodeficiency Diseases Around the new, standardized methods in indoor allergen assessment; Review strategic objectives of World NHANES and the allergy component. Fred Modell 2:25 Vaccine-Associated Paralytic Polio and Other Live Attenuated Course Vaccine-Associated Disease in Immunodeficient Infants Antonio Condino-Neto, MD PhD 1609 Allergen Immunotherapy: The Nuts and the Bolts 2:50 Clinical Cases: Diagnosis and Management of Primary (Part 2) Immunodeficency Around the World 2:00 to 3:00 pm Elham M. Hossny, MD PhD FAAAAI Convention Center, Upper Level, Room 30CDE Pre-registration and ticket required. No fee. 3:15 Question & Answer Credit: 1.00 CME / 1.20 CE 3:25 Break Moderator: Michael R. Nelson, MD PhD FAAAAI Moderators: Elham M. Hossny, MD PhD FAAAAI 2:00 SCIT and SLIT: Optimal Dosing, Regimen and Duration Mona I. Kidon, MD FAAAAI Harold S. Nelson, MD FAAAAI 3:35 Defects of Human Immunity and Mycobacterium Diseases Around 2:30 Allergen Immunotherapy: Practical Considerations, Cost- the World Effectiveness, Adherence and Quality of Life Stephanie Boisson-Dupuis, MD Cheryl S. Hankin, PhD 4:00 Molecular Mechanisms of Hyper IgE Syndromes Upon completion of this session, participants should be able to: Describe how immuno- Speaker to be announced. therapy can easily be dosed and the knowledge gaps we still have in this field; Discuss 4:25 Malnutrition, Vitamin Deficiencies, the Immune System and when doses might need to be adjusted for SCIT and for SLIT. Infections: Time to Revisit Our Knowledge Raz Somech, MD PhD 4:50 Question & Answer

32 Allied Health Session ticket required fee required included in the Virtual Annual Meeting FRIDAY, FEBRUARY 28

Course Breakout Sessions Course Attendees may attend one of the following sessions. 1611 Career Building for the Junior Investigator Pre-registration and ticket required. Fee: $25. Sessions are limited to 2:00 to 5:00 pm registered attendees. Convention Center, Upper Level, Room 1AB 3:00 to 5:00 pm Credit: 2.75 CME / 3.20 CE 1609A/D Hands-On Workshop: Media Fill Test and Moderator: Laura B. Fanning, MD Extract Preparation Management 2:00 Panel Discussion: Career Advice from Established Investigators: Convention Center, Upper Level, Room 32AB Strategies to Establish Scientific/Clinical Expertise Credit: 1.00 CME / 1.20 CE Effective Time Management Donald W. Aaronson, MD FAAAAI Effective Lab Management Michael S. Blaiss, MD FAAAAI Andrea J. Apter, MD MA MSc FAAAAI Susan E. Kosisky, BS MHA Kathleen C. Barnes, PhD FAAAAI Cecilia Mikita, MD MPH FAAAAI Joshua A. Boyce, MD FAAAAI Michael R. Nelson, MD PhD FAAAAI James E. Gern, MD FAAAAI Upon completion of this session, participants should be able to demonstrate the ability to Mitchell H. Grayson, MD FAAAAI make a sterile immunotherapy vial. 3:05 Question & Answer 1609B/C Allergen Immunotherapy Prescription Writing: 3:20 Break Cross-Reactivity, Proteolytic Enzymes, Diluents 3:40 Panel Discussion: Career Advice from Junior Investigators: and Other Factors Time Management Strategies Convention Center, Upper Level, Room 33AB Strategies for Work and Family Life Balance Credit: 1.00 CME / 1.20 CE Data Management Rohit Katial, MD FAAAAI Grant Writing Bryan L. Martin, DO FAAAAI Nora A. Barrett, MD FAAAAI Michael S. Tankersley, MD FAAAAI Patrick J. Brennan, MD PhD Upon completion of this session, participants should be able to demonstrate the proper Taylor A. Doherty, MD FAAAAI method for writing immunotherapy prescriptions for optimal efficacy and safety. Tanya M. Laidlaw, MD FAAAAI Brian P. Vickery, MD FAAAAI Course 4:45 Question & Answer 1610 Personalized Medicine Approaches in Asthma Upon completion of this session, participants should be able to: Discuss how to develop a specific clinical and scientific expertise; Discuss how to manage their time effectively and and Allergy how to choose roles and projects wisely; Describe benchmarks of success. 2:00 to 5:00 pm Convention Center, Upper Level, Room 8 Course Credit: 2.75 CME / 3.20 CE Moderator: Antonella Cianferoni, MD PhD 1612 Hands-On Rhinolaryngoscopy 2:00 CyTOF Flow: The New Frontier 2:00 to 5:00 pm Jonathan M. Irish, PhD Convention Center, Upper Level, Room 30AB Pre-registration and ticket required. Fee: $50. 2:30 Lessons Learned from Genetic Diseases of Allergy Credit: 2.75 CME / 3.30 CE Joshua D. Milner, MD Moderator: Jerald W. Koepke, MD FAAAAI 3:10 Break 2:00 Intro to Rhinolaryngoscopy 3:30 Using Biomarkers and Genomics to Personalize Therapeutics for Jerald W. Koepke, MD FAAAAI Allergy and Asthma 3:15 Break Stanley J. Szefler, MD FAAAAI 3:30 Hands-On Instruction 4:05 Establishing a Personalized Medicine Program: The Harvard Allen D. Adinoff, MD FAAAAI Experience Kevin R. Murphy, MD Scott T. Weiss, MD MS Grant C. Olson, MD 4:40 Question & Answer Donald W. Pulver, MD FAAAAI Upon completion of this session, participants should be able to: Discuss the availability C. Ross Westley, MD FAAAAI for genetic variation in disease risk, progression and therapy; Describe readily available predictive tests (genetic and non-genetic); Describe the use and cost effectiveness of a Upon completion of this session, participants should be able to: Describe the surgical personalized medicine approach in clinical practice. anatomy of the upper airway, including the nasal cavity, and ; Identify examples of normal and abnormal anatomy, as well as disease presentations and post-operative changes found with endoscopic examination of the upper airway; Identify indications for and the use of the fiberoptic rhinoscope in the allergist’s office.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 33 FRIDAY, FEBRUARY 28

Course Problem-Based Learning Workshop 1613 Interpretation of Pulmonary Function Tests (PFTs) 1801 Diagnosis of Patients with Defects in Innate 2:00 to 5:00 pm Immunity Including TLR Pathway Defects Convention Center, Upper Level, Room 33C 5:00 to 6:15 pm Pre-registration and ticket required. No fee. Convention Center, Upper Level, Room 3 Credit: 3.00 CME / 3.50 CE Pre-registration and ticket required. Fee: $50. Moderator: Mark F. Sands, MD FAAAAI Credit: 1.25 CME / 1.50 CE 2:00 Introductory Remarks PBL Facilitator: Richard L. Wasserman, MD PhD FAAAAI 2:05 Pathophysiology and the PFT Content Lecturer: Dinakantha Kumararatne, MD PhD Mark F. Sands, MD FAAAAI Upon completion of this session, participants should be able to: Describe the currently 2:30 Performing PFT: Video Demonstration known causes of defective innate immunity; Describe the clinical presentation of defects John M. Weiler, MD FAAAAI in innate immunity; Discuss the selection and interpretation of laboratory tests to diagnose defects in innate immunity. 2:40 Interpretation of the PFT: Putting it All Together Donald P. Tashkin, MD Q & A Workshop 3:10 Question & Answer 3:25 Break 1802 Di!cult to Manage Asthma: The Very Young, the 3:30 Hands-On Workshop Very Old and the Obese Donald W. Cockcroft, MD FAAAAI 5:00 to 6:15 pm Meredith C. McCormack, MD Convention Center, Mezzanine Level, Room 14AB Riccardo Polosa, MD PhD FAAAAI Credit: 1.25 CME / 1.50 CE Mark F. Sands, MD FAAAAI Moderator: Timothy J. Craig, DO FAAAAI Donald P. Tashkin, MD 5:00 What to Do When Your Patient Can’t Tell You What’s Wrong: John M. Weiler, MD FAAAAI Challenges in the Diagnosis and Management of Asthma in Upon completion of this session, participants should be able to: Describe the components Children Under Age Five of pulmonary function testing; Recognize simple and complex obstructive and restrictive Joseph D. Spahn, MD pulmonary abnormalities; Interpret PFTs from asthma and COPD to fixed and variable obstructive abnormalities, as well as interstitial and other restrictive diseases. 5:15 Pitfalls in the Diagnosis and Management of Asthma in Older Adults: An Evidence-Based Update Tolly Epstein, MD MS Clinical Research Symposium 5:30 New Insights into the Obese Asthma Phenotype: Diagnostic and 1621 Tools of the Trade Therapeutic Challenges in Obese Asthmatics 2:00 to 3:15 pm Juan C. Celedon, MD DrPH FAAAAI Marriott North Tower, Lobby Level, Torrey Pines 3 5:45 Question & Answer Credit: 1.25 CME / 1.50 CE Upon completion of this session, participants should be able to: Identify emerging diag- Moderator: Jaime E. Ross, RN nostic modalities for asthma that may be useful in children under age 5 years; Develop 2:00 What You Need to Know to Prepare for an FDA Audit strategies to distinguish asthma from other potential comorbid conditions in elderly Kim E. Mudd, RN MSN CCRP asthmatics and implement age-appropriate management strategies in older asthmatics; Summarize recent data regarding the obese asthmatic phenotype and critically assess 2:30 Developing Your Monitoring Plan: Improving the Quality of the current management strategies in this subgroup of asthmatics. Research Janet S. Kamilaris, RN Q & A Workshop 3:00 Question & Answer Upon completion of this session, participants should be able to: Describe the components 1803 What are Damp Buildings and How Do They of a monitoring plan; List the methods to keep a clinical trial site ready for an audit; Cause Problems? Identify the proper use of a note to file and describe its limitations. 5:00 to 6:15 pm Convention Center, Upper Level, Room 5AB Allied Health Plenary Credit: 1.25 CME / 1.50 CE 1701 Cybersecurity: Technology in Practice Moderator: Jay M.Portnoy, MD FAAAAI 4:00 to 5:15 pm 5:00 Innate Immunity Factors from Fungi Marriott North Tower, Lobby Level, Marriott Hall Salon 5 Anthony A. Horner, MD FAAAAI Credit: 1.25 CME / 1.50 CE 5:15 Damp Buildings, Respiratory Disease and Asthma Moderator: Sally A. Noone, RN MSN CCRC Kari E. Reijula, MD PhD FAAAAI Larry Thompson 5:30 Allergens from Damp Housing Upon completion of this session, participants should be able to: Identify actions to protect Eva-Maria King, PhD hardware and software; Describe how to implement security measures to protect a 5:45 Question & Answer practice; Identify how to set up emergency plans in case of a breach. Upon completion of this session, participants should be able to: Review the multiple expert panels/reports and Position Statements concluding that there is adequate evidence for respiratory health impacts, including new onset asthma, due to damp buildings; Describe the challenges of quantifying dampness and establishing acceptable moisture levels; Recognize the several plausible mechanisms that underlie the adverse respiratory impacts of the damp building effect.

34 Allied Health Session ticket required fee required included in the Virtual Annual Meeting FRIDAY, FEBRUARY 28

Q & A Workshop Seminars 1804 The Science Behind Complementary and 5:15 to 6:15 pm Alternative Medicine Pre-registration and ticket required. Fee: $40. Refreshments included. Sessions and refreshments are limited to 30 people. 5:00 to 6:15 pm Credit: 1.00 CME / 1.20 CE Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE 1901 Allergen Immunotherapy or Omalizumab in Moderator: William S. Silvers, MD FAAAAI Asthma: When to Use Which? 5:00 Role of Vitamin D in Allergic Inflammation Thomas B. Casale, MD FAAAAI Katrina Jane Allen, MD PhD FAAAAI Jonathan Corren, MD 5:15 Immunomodulation by Chinese Herbal Medicine in Food Allergy Marriott South Tower, Level 3, Balboa Julie Wang, MD FAAAAI Upon completion of this session, participants should be able to: Review efficacy of AIT in 5:30 Probiotics, Prebiotics and Synbiotics For Prevention and asthma and safety of AIT in moderate to severe asthma; Review studies of omalizumab alone and in combination with AIT in asthma; Make recommendations on individual use of Treatment of Allergic Disease these drugs and in combination for asthma. Mimi L.K. Tang, MD PhD FAAAAI 5:45 Question & Answer 1902 When is an Elevated IgE Level a Sign of Upon completion of this session, participants should be able to: Explain the role of vitamin Immunode!ciency? D in allergic inflammation; Discuss the immunomodulatory effects of Chinese herbal Alexandra F. Freeman, MD medicine for food allergy; Describe the role of prebiotics and probiotics in the prevention Hans D. Ochs, MD and treatment of allergy. Marriott South Tower, Level 3, Mission Hills Upon completion of this session, participants should be able to: Review the differential di- Q & A Workshop agnosis of an elevated IgE level; Discuss the work up necessary in patients with elevated IgE levels; Review the Hyper IgE syndromes. 1805 Di"cult Situations in Practice Management 5:00 to 6:15 pm 1903 How to Assess and Manage a Child with Multiple Convention Center, Mezzanine Level, Room 16AB Positive Environmental and Food Allergy Tests Credit: 1.25 CME / 1.50 CE Sami L. Bahna, MD DrPH FAAAAI Moderator: Tao T. Le, MD MHS FAAAAI Anna H. Nowak-Wegrzyn, MD FAAAAI 5:00 Employment Agreements and Partnerships Marriott South Tower, Level 3, Cardiff Adhuna C. Mathuria, MD Upon completion of this session, participants should be able to: Explain the prevalence Robert J. Holzhauer, MD MBA FAAAAI and difference between classic food allergies and pollen-food allergy syndrome; Describe the utility of skin prick, fresh food skin prick, serum specific IgE testing, component 5:15 Hiring and Firing resolved diagnostics and oral food challenge in assessment of complex patients with mul- Vinay Mehta, MD FAAAAI tiple food and environmental sensitizations; Discuss the management of complex patients Weily Soong, MD FAAAAI with multiple food and environmental sensitivities and/or allergies. 5:30 Marketing and Referral Development 1904 So the Patient Has : What Next? Sakina S. Bajowala, MD FAAAAI Amy D. Klion, MD Stanley M. Fineman, MD MBA FAAAAI Catherine R. Weiler, MD PhD FAAAAI 5:45 Question & Answer Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Identify and address Upon completion of this session, participants should be able to: Review diagnosis of difficult situations regarding employment and partnership contracts; Evaluate difficult various hypereosinophilic syndromes; Describe identification of secondary eosinophilia; situations in hiring and firing; Investigate difficult situations in marketing. Discuss therapeutic approaches to hypereosinophilic syndrome. International Reception 1905 Mechanisms and Biomarkers Related to 5:00 to 6:00 pm Sublingual and Subcutaneous Immunotherapy Convention Center, Upper Level, Ballroom 6CF Giovanni Passalacqua, MD All international members and delegates are invited to attend this Mohamed H. Shamji, BSc MSc PhD reception. Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Discuss humoral mecha- Allied Health Wine and Cheese Reception nisms of SCIT and SLIT; Discuss cellular mechanisms of SCIT and SLIT; Discuss novel biomarkers of successful SCIT and SLIT. 5:15 to 6:15 pm Marriott South Tower, Level 4, La Costa All allied health members and their guests are invited to attend this reception for an evening of networking with other allied health Annual Meeting Seminars and Workshops professionals. Programmed by the AAAAI. Annual Meeting Seminars and Workshops funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 35 FRIDAY, FEBRUARY 28

2014 Federation of RSLAAIS Assembly Forum, Business Meeting and Reception 4:45 to 6:30 pm San Diego Convention Center, Upper Level, Room 31AB 4:45 Wine and Cheese Welcome Reception 5:10 RSLAAIS Assembly Business Meeting Moderator: Sharon B. Markovics, MD FAAAAI, RSLAAIS Chair 5:20 ACOs: Will they really be “accountable?” Co-Moderators: Marshall P. Grodofsky, MD FAAAAI, RSL Governor Jody T. Inglefield, MD FAAAAI, RSL Governor Speakers: Jonathan L. Bayuk, DO FAAAAI Hampden County Physician Associates Springfield, MA Warner W. Carr, MD FAAAAI Allergy and Asthma Associates of Southern California 6:10 Joint Council of Allergy, Asthma and Immunology (JCAAI) Update Richard W. Honsinger, MD MACP FAAAAI President, JCAAI 6:15 American Board of Allergy and Immunology (ABAI) Update Stephen I. Wasserman, MD FAAAAI President, ABAI 6:20 What’s Next With RSLs 6:30 Adjourn

36 Allied Health Session ticket required fee required included in the Virtual Annual Meeting

SATURDAY, 1

Seminars or scheduled splenectomy. 7:00 to 8:00 am 2006 An Update on the Diagnosis and Treatment of Pre-registration and ticket required. Fee: $40. Continental breakfast Chronic Granulomatous Disease (CGD) included. Sessions and meals are limited to 30 people. Alexandra F. Freeman, MD Credit: 1.00 CME / 1.20 CE Peter J. Mustillo, MD FAAAAI 2001 Microbiota and Asthma Marriott South Tower, Level 3, Mission Hills Yvonne Huang, MD Upon completion of this session, participants should be able to: Describe current diagnos- Marriott South Tower, Level 3, Marina Ballroom Salon D tic tests for CGD; Review treatment options for patients with CGD including consideration for bone marrow transplant. Upon completion of this session, participants should be able to: Review the importance of the microbiota in asthma and allergic disorders; Discuss the dangers of inappropriate 2007 How to Be a Mold Sleuth antibiotic use on the microbiota; Describe fostering a healthy microbiota. Anupma B. Dixit, PhD 2002 Provocative Testing for Exercise-Induced Asthma: H. James Wedner, MD FAAAAI Methacholine vs. Mannitol vs. Exercise Marriott South Tower, Level 3, Cardiff Donald W. Cockcroft, MD FAAAAI Upon completion of this session, participants should be able to: Discern the quality of building inspection reports regarding water damage and mold colonization in housing; John M. Weiler, MD FAAAAI Describe mold sampling data to assess the significance of occupant exposure to molds Marriott South Tower, Level 3, Marina Ballroom Salon E indoors. Upon completion of this session, participants should be able to: Discuss indications/ contraindications for bronchoprovocation challenges in patients with EIB; Describe the 2008 Pathogenic Bacteria and Viral Illness: Are They strengths and weaknesses of each in the evaluation of hyper-reactivity; Identify metha- Associated? What the Microbiome Tells Us choline and mannitol challenge as potential tests for monitoring asthma treatment. James E. Gern, MD FAAAAI 2003 Monitoring and Managing Non-Infectious Kirsten Kloepfer, MD Complications of Common Variable Immune Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Describe the association De!ciency between pathogenic bacteria and asthma exacerbations; Discuss potential mechanisms Charlotte -Rundles, MD PhD FAAAAI for viral infections to promote infections with pathogenic airway bacteria; Discuss Rima A. Rachid, MD FAAAAI potential treatment implications related to bacterial infections, wheezing illnesses and Marriott South Tower, Level 3, Marina Ballroom Salon F exacerbations of asthma. Upon completion of this session, participants should be able to: Review the non-infectious 2009 Aspirin and Antibiotic Desensitization complications of CVID; Discuss how to monitor and treat these complications. Anahita F. Dioun, MD FAAAAI 2004 There’s an App for That: Using Smart Phones, Catherine R. Weiler, MD PhD FAAAAI Tablets and Web Tools for Clinical Practice Marriott South Tower, Level 3, Miramar Tao T. Le, MD MHS FAAAAI Upon completion of this session, participants should be able to: Describe what is needed Melinda M. Rathkopf, MD FAAAAI to perform a desensitization in the office; Discuss the desensitization of aspirin allergic patients; Describe the desensitization of antibiotic allergic patients. Marriott South Tower, Level 3, Marina Ballroom Salon G Upon completion of this session, participants should be able to: Describe the various 2010 Fifty Shades of : device options and platforms available to the clinician; Discuss the various apps available Identifying the Phenotypes for the various devices and how to maximize their use; Identify web tools useful in the allergy practice. Juan Pablo Abonia, MD Mirna Chehade, MD MPH 2005 Immunizing the Immunode!cient Patient Marriott South Tower, Level 1, Point Loma Francisco A. Bonilla, MD PhD FAAAAI Upon completion of this session, participants should be able to: Demonstrate the ability M. Louise Markert, MD PhD FAAAAI to identify EoE co-morbidities; Recognize when to suspect EoE given the medical history, Marriott South Tower, Level 3, Balboa whenever esophageal eosinophilia is found; Discuss how to investigate for other poten- Upon completion of this session, participants should be able to: Identify laboratory findings tially associated diseases with EoE that require medical attention. that may predict when live viral vaccinations may be administered to patients with cellular 2011 Getting Ready for ICD-10: Cracking the Code immunodeficiency; Describe factors involved in timing of live viral vaccinations after im- munosuppressive medications; Discuss vaccinations and timing for patients with asplenia Priya J. Bansal, MD FAAAAI Marshall P. Grodofsky, MD FAAAAI Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Describe the differences between ICD-10 and ICD-9-CM; Discuss the impact of ICD-10 on billing and coding; Identify strategies for implementing ICD-10 in clinical practice. 2012 Component-Resolved Diagnosis for Inhalant Annual Meeting Seminars Allergies Programmed by the AAAAI. Annual Meeting Seminars funded Reto Crameri, PhD through an educational grant from Merck. Peter Schmid-Grendelmeier, MD PhD Marriott South Tower, Level 1, Santa Rosa Upon completion of this session, participants should be able to: Describe cross-reactivity between various inhalant allergens and food allergens; Define predictive value of CRD for disease outcome; Identify better selection criteria for allergen-specific immunotherapy.

38 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

2013 Cockroach Immunotherapy Allied Health Workshop Luisa Karla P. Arruda, MD PhD FAAAAI 2023 Management of Atopic Dermatitis William W. Busse, MD FAAAAI 6:45 to 8:00 am Marriott South Tower, Level 4, La Costa Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Upon completion of this session, participants should be able to: Discuss epidemiologic studies on cockroach allergy, including outcomes of abatement procedures; Describe Pre-registration and ticket required. No fee. characteristics of cockroach allergens and composition of cockroach extracts currently Credit: 1.25 CME / 1.50 CE available; Discuss ongoing and published studies on cockroach immunotherapy and new Moderator: William R. Blouin, ARNP perspectives for treatment of cockroach allergy. Instructors: 2014 Alternative Pathways of Antigen-Mediated Carla M. Duff, CPNP MSN Sally A. Noone, RN MSN CCRC Anaphylaxis Karol G. Timmons, RN MS CPNP Mary Beth Hogan, MD FAAAAI Upon completion of this session, participants should be able to: Identify and differentiate Wei Zhao, MD PhD FAAAAI atopic dermatitis from other skin conditions; Demonstrate appropriate skin care including Marriott South Tower, Level 4, Catalina wet to dry dressings; Discuss how to teach patients and families about proper skin care. Upon completion of this session, participants should be able to: Review the traditional pathway of anaphylaxis; Discuss the role of basophils and neutrophils in the pathogenesis Allied Health Workshop of anaphylaxis; Distinguish IgE (mast cell) mediated anaphylaxis from IgG/Platelet Activat- ing Factor as an alternative mechanism of anaphylaxis. 2024 Bring Your Own Pediatric Food Challenge 2015 Interpreting Anti-IL5 Trial Data: Implications for Experience Asthma, EoE and HES Pathophysiology 6:45 to 8:00 am Steven J. Ackerman, PhD Marriott North Tower, Lobby Level, Torrey Pines 3 Sameer K. Mathur, MD PhD FAAAAI Credit: 1.25 CME / 1.50 CE Marriott South Tower, Level 4, Coronado Moderator: Suzanne K. Carlisle, RN BSN CCRP Upon completion of this session, participants should be able to: Discuss the different types Elisabeth S. Stieb, RN BSN AE-C of anti-IL-5 therapy in use in clinical trials; Review the outcomes of anti-IL-5 therapy for Anne M. Hiegel, RN CRC asthma, eosinophilic esophagitis and hypereosinophilic syndrome. Upon completion of this session, participants should be able to: Discuss solutions to common problems encountered when conducting oral food challenges; Develop access to Allied Health Workshop a network of health care providers conducting food challenges and interact with them as needed throughout the year. 2021 The Ins and Outs of Management of Chronic Eosinophilic Esophagitis Allied Health Workshop 6:45 to 8:00 am 2025 Exploring the Spectrum of Gluten-Related Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Disorders Moderator: Debra A. Sedlak, MSN CPNP 6:45 to 8:00 am Marriott North Tower, Lobby Level, Atlanta 6:45 Are You Missing the EoE Patient? It Starts with the History Credit: 1.25 CME / 1.50 CE Katie J. Atkinson, RN CFNP Isabel J. Skypala, PhD 7:00 Diagnosis and Treatment Options: Diet or Steroids? Berber Vlieg-Boerstra, PhD RD Seema Sharma Aceves, MD PhD FAAAAI Upon completion of this session, participants should be able to: Discuss the various 7:15 Meeting the Patient’s Needs: Nutrition and Quality of Life gluten-related disorders; Discuss strategies based on the individual patient’s gluten- Marion E. Groetch, MS RD related disorder. 7:30 Question & Answer Upon completion of this session, participants should be able to: List the common symp- Allied Health Workshop toms of esosinophilic esophagitis (EoE) and the history that may trigger suspicion of EoE; Identify appropriate treatment options; Define how to guide patients on elimination diets 2026 Pharmacology of Tobacco Cessation Medications to meet nutritional needs and maintain quality of life. 6:45 to 8:00 am Marriott North Tower, Lobby Level, Chicago Allied Health Workshop Credit: 1.25 CME / 1.50 CE Beth A. Allison, NP 2022 What Allied Health Professionals Need to Know Upon completion of this session, participants should be able to: Describe nicotine About Drug Sensitivity dependence and nicotine withdrawal; Discuss evidence-based use of smoking cessation 6:45 to 8:00 am medications. Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Credit: 1.25 CME / 1.50 CE Moderator: Kim E. Mudd, RN MSN CCRP Miguel A. Park, MD Upon completion of this session, participants should be able to: Define the key compo- nents of the drug allergy history; Discuss diagnostic tests and work-up for drug allergies; Review the treatment options for drug allergies.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 39 SATURDAY, MARCH 1

Plenary Hands-On Workshop 2101 Immunotherapy: Mechanism, 2251 Adolecent Allergy/Asthma Simulation Outcomes and Markers 10:00 am to 2:15 pm 8:15 to 9:45 am Convention Center, Ground Level, Exhibit Hall B Convention Center, Ground Level, Exhibit Hall A Pre-registration and ticket required. No fee. Credit: 1.50 CME / 1.80 CE Credit: 0.50 CME / 0.60 CE Moderator: Linda Cox, MD FAAAAI Participate in a live simulation of treating an adolescent patient experiencing allergies and asthma, working with faculty and 8:15 Tolerance to Allergens: How it Develops and How it Can be standardized patients from the University of San Diego. Induced Upon completion of this session, participants should be able to demonstrate appropriate Cezmi A. Akdis, MD FAAAAI clinical skills to be used when treating an adolescent patient at risk of, or experiencing, 8:45 Biomarker Predictors of Effective Immunotherapy allergies or asthma. Stephen R. Durham, MA MD FRCP 9:15 SIT Outcomes: Examining the Data for Efficacy, Safety, Adherence Hands-On Workshop and Costs Linda Cox, MD FAAAAI 2252 Adult Anaphylaxis Simulation Upon completion of this session, participants should be able to: Discuss the benefits of 10:00 am to 2:15 pm specific immunotherapy; Describe factors affecting safety of specific allergy immunother- Convention Center, Ground Level, Exhibit Hall B apy; Discuss the use of biomarkers to predict the response to immunotherapy to . Pre-registration and ticket required. No fee. Credit: 0.50 CME / 0.60 CE Posters Participate in a live simulation of treating an adolescent patient experiencing allergies and asthma, working with faculty and 7:00 am to 6:00 pm standardized patients from the University of San Diego. Convention Center, Ground Level, Exhibit Hall B Upon completion of this session, participants should be able to demonstrate appropri- Posters on display from 7:00 am to 6:00 pm. Authors present from ate clinical skills to be used when treating an adult patient at risk of, or experiencing 9:45 to 10:45 am. anaphylaxis. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors. Symposium 2201 Asthma Therapeutics: Advances in Biologics and 2301 Oral Immunotherapy (OIT) Drugs 10:45 am to 12:00 pm 2202 Asthma Epidemiology Convention Center, Ground Level, Exhibit Hall A 2203 Primary Antibody De!ciencies Credit: 1.25 CME / 1.50 CE Moderator: J. Andrew Bird, MD FAAAAI 2204 Asthma Epidemiology, Risk Factors, and Public 10:45 Current Protocols for Oral Immunotherapy Health I Kari C. Nadeau, MD PhD FAAAAI 2205 Aerobiology I 11:05 Oral Immunotherapy: Native or Modified Allergen? 2206 Insect Hypersensitivity/Anaphylaxis Hugh A. Sampson, MD FAAAAI 11:25 When Should We Stop Oral Immunotherapy? When Should it be 2207 HAE and Restarted? 2208 Population Health in Asthma Giovanni B. Pajno, MD FAAAAI 2209 Healthcare Delivery in Primary 11:45 Question & Answer Upon completion of this session, participants should be able to: Identify patients with Immunode!ciency IgE-mediated food allergy who represent a target for OIT; Examine different protocols for 2210 Diagnostics different foods; Outline the risk-benefit ratio of OIT. 2211 Oral Immunotherapy 2212 Mechanisms of Cytokines and Chemokines 2213 Role of Granulocytes and Mast Cells in Mechanisms of Allergic Disease 2214 Allied Health Poster Session

40 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Symposium Symposium 2302 World Allergy Forum: Anaphylaxis: 2304 NHLBI’s Clinical Asthma Research Network’s From Mechanisms to Novel (AsthmaNet) Approach to Key Asthma Questions Therapeutics 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6A Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: William W. Busse, MD FAAAAI Moderators: Linda Cox, MD FAAAAI James P. Kiley, PhD Lanny J. Rosenwasser, MD FAAAAI 10:45 What Roles Do Novel and Not-So Novel Medications Have in 10:45 Diagnosis and Prevention of IgE and Non-IgE-Mediated Treating Preschool Wheezers? Anaphylaxis Leonard B. Bacharier, MD FAAAAI Fred D. Finkelman, MD 11:05 Is LABA or Increased Dose of ICS the Best Step-Up Therapy for 11:05 Causes of Anaphylaxis African Americans: Do Children Respond Differently Than Adults? Motohiro Ebisawa, MD PhD FAAAAI Michael E. Wechsler, MD 11:25 Treatment of Anaphylaxis: Recent Advances 11:25 Does Vitamin D Have a Role in Clinical Asthma? F. Estelle R. Simons, MD FAAAAI Mario Castro, MD MPH 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: Outline therapeutic Upon completion of this session, participants should be able to: List the etiology and options to optimize asthma treatment early in life; Describe the unique therapeutic ap- mechanisms of anaphylaxis; Recognize the most common triggers in anaphylaxis; Discuss proaches that produce improved outcomes in African-American patients; Discuss the use the management of anaphylaxis including an action plan for prevention. of Vitamin D as a therapeutic agent for treating asthma.

Symposium Symposium 2303 The Expanding Universe of Primary 2305 The Indoor Air Exposome in Work, School and Immunode!ciency Home: Taking in the Whole Picture 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: M. Teresa De La Morena, MD Moderator: Jill A. Poole, MD FAAAAI 10:45 The Ever-Expanding Spectrum of PID 10:45 Exposure Assessments and Risk of Disease in Multiple Settings Troy R. Torgerson, MD PhD Wanda Phipatanakul, MD MS FAAAAI 11:05 Diagnosing PID in 2014 11:05 Pesticides, Chemicals and Other Exposures Matter in Allergic Kathleen E. Sullivan, MD PhD FAAAAI Disorders 11:25 Supporting and Reconstituting Immune Function Rachel L. Miller, MD FAAAAI M. Louise Markert, MD PhD FAAAAI 11:25 Evaluation and Management of Patients Presenting with 11:45 Question & Answer Suspected Building-Related Illness Upon completion of this session, participants should be able to: Describe how discovery Karin A. Pacheco, MD MSPH FAAAAI of new immunodeficiencies leads to new insights into immune system biology; Develop a stepwise approach to diagnosing the broad range of immunodeficiencies; Discuss the 11:45 Question & Answer latest developments in the therapy of immunodeficiency. Upon completion of this session, participants should be able to: Describe the most com- mon indoor air quality issues that cause negative health effects; Identify the emerging role of pesticides, chemicals and other exposures in modulating allergic sensitization, epigenetic markers and health outcomes; Outline best practices for clinical assessment of susceptible workers exposed to poor office indoor air quality and remediation strategies to create a healthy office indoor air quality environment.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 41 SATURDAY, MARCH 1

Symposium Symposium 2306 Mechanisms of Virus-Induced Asthma 2308 The Relevance of Microbes and Their Diversity in 10:45 am to 12:00 pm Chronic Rhinosinusitis and Asthma Convention Center, Mezzanine Level, Room 15AB 10:45 am to 12:00 pm Credit: 1.25 CME / 1.50 CE Convention Center, Upper Level, Room 30ABCDE Moderator: Mitchell H. Grayson, MD FAAAAI Credit: 1.25 CME / 1.50 CE 10:45 Local Interactions Betweens Dendritic Cells and T Cells in the Moderator: Martin Wagenmann, MD FAAAAI Antiviral Immune Response 10:45 Asthma and the Relevance of the Microbiome Kevin Legge, PhD Trevor ThomasHansel, MD PhD 11:05 The Neutrophilic Antiviral Response: Is There More Than Meets 11:05 Biofilms in Chronic Rhinosinusitis the Eye? James Palmer, MD Dorothy S. Cheung, MD FAAAAI 11:25 Don’t Underestimate Viruses as Relevant Factors in the 11:25 The Chronic NKT-Macrophage Axis in Asthma Development of Chronic Airway Disease Michael J. Holtzman, MD FAAAAI Daniel J. Jackson, MD 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: Discuss how innate Upon completion of this session, participants should be able to: Discuss the relevance of lymphoid cells contribute to airway inflammation in response to viral infections; Discuss microbial diversity in the development of asthma; Define alterations in resident microbiota new understanding of the neutrophilic response during viral infections; Describe how NKT relevant for chronic rhinosinusitis presentation and treatment; Recognize the importance cells and macrophages drive a chronic post-viral asthma phenotype. of viral infections in the development of chronic lower airway disease.

Symposium Allied Health Workshop 2307 Innovative Methods for Reducing Asthma 2311 Anaphylaxis Recognition and Management: Disparities What People Need to Know 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Mary E. Bollinger, DO Moderator: Debra A. Sedlak, MSN CPNP 10:45 Reaching Kids Where They Are: School-Based Asthma Panelists Interventions William R. Blouin, ARNP Minal R. Patel, PhD MPH Vivian P. Hernandez-Trujillo, MD FAAAAI 11:05 Telemedicine: How Can it be Utilized to Decrease Barriers to Gabriel Ortiz, MPAS PA-C Asthma Healthcare? Upon completion of this session, participants should be able to: Discuss how patients, Tamara T. Perry, MD teachers and members of the lay community can recognize the signs and symptoms of anaphylaxis; Discuss how to plan and use appropriate treatment. 11:25 Can Web-Based and Mobile Applications Improve Asthma Outcomes?

Giselle Mosnaim, MD MS FAAAAI Allied Health Workshop 11:45 Question & Answer 2312 Atopic Dermatitis: Advancing Pro!ciency in Upon completion of this session, participants should be able to: Describe the impact of Management web and mobile-based interventions for asthma healthcare delivery; Discuss the impact and cost-effectiveness of school-based asthma interventions on health outcomes; Discuss 10:45 am to 12:00 pm the impact of asthma subspecialty care via telemedicine on health outcomes. Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Pre-registration and ticket required. No fee. Credit: 1.25 CME / 1.50 CE Moderator: Pooja Varshney, MD 10:45 Atopic Dermatitis: Immune Dysregulation Gregory M. Metz, MD 11:00 Atopic Dermatitis: Management Strategies Karen L. Gregory, DNP APRN-BC RRT AE-C 11:15 Hands-On Instruction Upon completion of this session, participants should be able to: Discuss the complex immune dysregulation that occurs in atopic dermatitis; Describe the general concepts of managing atopic dermatitis; Identify signs and symptoms that warrant further investiga- tion (food allergy, immune deficiency, secondary infections).

42 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Allied Health Workshop Allied Health Workshop 2313 Immune Replacement Therapy: The Route to 2316 Using Technology to Improve Patient Adherence Travel 10:45 am to 12:00 pm 10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Atlanta Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Pre-registration and ticket required. No fee. Moderator: John D. Milewski, Med. Admin. Credit: 1.25 CME / 1.50 CE David R. Stukus, MD FAAAAI Moderator: Ginger S. LaBelle, CPNP 11:30 Question & Answer 10:45 SCIG Upon completion of this session, participants should be able to: Discuss the recognition of Kristin Epland, NP health literacy in patients and its impact on adherence to treatment plans; Review tools available for use in clinical practice; Discuss ways to utilize both social media and mobile 11:00 IVIG devices to improve office and provider efficiency, patient engagement and overall care in M. Elizabeth M. Younger, CRNP PhD the clinical setting. 11:15 Hands-On Instruction Upon completion of this session, participants should be able to: Describe the pros and Allied Health Professional Assembly Forum cons of both IV and SC therapy; Identify the supplies and devices used for SC infusions. 12:30 to 1:30 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 6 Allied Health Symposium All allied health professionals are invited to attend this forum. Box 2314 The Contribution of Aerobiology Towards Asthma lunches included. Morbidity Seminars 10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Torrey Pines 3 12:30 to 1:30 pm Credit: 1.25 CME / 1.50 CE Pre-registration and ticket required. Fee: $40. Box lunch included. Moderator: David L. Rosenstreich, MD FAAAAI Sessions and meals are limited to 30 people. 10:45 Association Between Tree Pollen Counts and Asthma ER Visits in Credit: 1.00 CME / 1.20 CE a High-Density Urban Center 2501 The Evolution of Childhood Wheezing to Asthma Sunit Jariwala, MD Leonard B. Bacharier, MD FAAAAI 11:05 The Impact of Mouse Allergen on Asthma Bradley E. Chipps, MD FAAAAI Susan L. Balcer-Whaley, MPH Marriott South Tower, Level 3, Marina Ballroom Salon D 11:25 Neighborhood Differences in Asthma Prevalence and Persistence Upon completion of this session, participants should be able to: Determine the diagnostic criteria for varied phenotypic expression of childhood asthma; Examine the progression of Matthew S. Perzanowski, PhD immunopathologic events in the development of childhood asthma; Examine the implica- 11:45 Question & Answer tion for treatment given the varied immunopathologic and phenotypic expressions. Upon completion of this session, participants should be able to: Describe the relationship between outdoor air quality components and asthma-related morbidities; Identify the 2502 Performing and Interpreting Spirometry: effect mouse allergen contributes to asthma in an urban environment. Understanding and Implementing the ATS/ERS Guidelines Allied Health Workshop James M. Quinn, MD FAAAAI 2315 Revenue Management with Correct Coding Kevin M. White, MD 10:45 am to 12:00 pm Marriott South Tower, Level 3, Marina Ballroom Salon E Marriott North Tower, Lobby Level, Chicago Upon completion of this session, participants should be able to: Identify the source and relevance of the ATS/ERS guidelines for lung function testing; Discuss the ATS/ERS recom- Credit: 1.25 CME / 1.50 CE mendations for correct performance of spirometry; Identfy ATS/ERS guidelines to interpret Moderator: Joan E. Hawkins spirometry and classify the severity of identified abnormalities. Teresa Thompson, CPC CMSCS CCC 11:30 Question & Answer 2503 Hereditary Angioedema: Diagnosis and Upon completion of this session, participants should be able to: List the current CPT Management guidelines; Describe the current information to code correctly to third party payer guide- Mark S. Dykewicz, MD FAAAAI lines; Discuss the current information regarding reviews from CMS, OIG, RAC and third Andrew J. MacGinnitie, MD PhD party payers. Marriott South Tower, Level 3, Marina Ballroom Salon F Upon completion of this session, participants should be able to: Review the mechanism of HAE; Discuss how and when to use the new therapies for HAE; Describe how to improve outcomes of your patients with HAE.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 43 SATURDAY, MARCH 1

2504 Making the Most of Your EMR: Meeting 2510 Quality Improvement and Patient Safety in Meaningful Use Allergy Practice Priya J. Bansal, MD FAAAAI Brad J. McClimon, MD A. Sean McKnight, MD FAAAAI Matthew A. Rank, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon G Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Discuss tips for optimizing Upon completion of this session, participants should be able to: Discuss the need for your current EMR; Discuss current state of Meaningful Use government incentive pay- allergists to consider, plan and perform quality projects; Discuss fundamental principles ments; Discuss clinical quality measures and PQRI reporting with your EMR. guiding quality improvement of allergic/immunologic diseases in the United States; Discuss potential quality improvement opportunities that could positively influence the 2505 When Should Bone Marrow Transplantation be outcomes of allergy, asthma and immunology education, research and patient care at the Considered in Primary Immunode!ciency? local and national level. Rebecca A. Marsh, MD 2511 Biologics Targeting the Immune Responses in Elena E. Perez, MD PhD FAAAAI Chronic Rhinosinusitis and Nasal Polyps Marriott South Tower, Level 3, Balboa Claus Bachert, MD PhD Upon completion of this session, participants should be able to: Review the primary immu- nodeficiency diseases for which BMT can be a curative treatment; Discuss how soon after Daniel L. Hamilos, MD diagnosis a patient with certain immunodeficiency disorders should be referred to a BMT Marriott South Tower, Level 1, Solana center; Describe any therapies to be avoided prior to a patient going to transplant. Upon completion of this session, participants should be able to describe biologic treat- ments under consideration for treatment of chronic rhinosinusitis. 2506 Viral Infections in the Allergic Host: What Factors May Be Synergistic? 2512 Immunotherapy with Immunomodulator Josh L. Kennedy, MD Therapy: Which Work and Which Do Not? Eva Kathryn Miller, MD Peter S. Creticos, MD FAAAAI Marriott South Tower, Level 3, Mission Hills Mohamed H. Shamji, BSc MSc PhD Upon completion of this session, participants should be able to: Evaluate the innate im- Marriott South Tower, Level 1, Santa Rosa mune response to viral infection in the exacerbating asthmatic, particularly the evidence Upon completion of this session, participants should be able to: Review new data on the of a deficient or overactive response; Discuss the role of the epithelium in asthmatic combination of immunotherapy and certain immunomodulators; Discuss the the possible responses to viral infection; Evaluate the role of allergy by examining the evidence that IgE mechanisms that might account for these findings, analyzing the mechanisms of im- responses are important predictors of asthma exacerbations. munotherapy in a new light. 2507 Biomass Smoke: Alternative Energy or Pollutant 2513 Evaluating Experimental Models of Allergic Source? Patricia Mason Fritz Anne K. Ellis, MD MSc FAAAAI Alisa M. Smith, PhD FAAAAI Martin Wagenmann, MD FAAAAI Marriott South Tower, Level 3, Cardiff Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to: Recognize the emergence Upon completion of this session, participants should be able to: Describe the most com- of a potentially significant source of community (neighborhood) air pollution; Discuss monly used methodologies for experimental nasal allergen challenge in the investigation the continuum and coherence of health effects from exposure to combustion emissions; of ; Describe the commonly used methodologies utilized in environmental Analyze the role of ambient air pollution on the health of non-urban populations. exposure unit-type studies of allergic rhinitis; Describe the advantages and disadvantages of both experimental models pertaining to the study of allergic rhinitis. 2508 The Intricacy of Penicillin Allergy Evaluation Eric M. Macy, MD FAAAAI 2514 Food Allergy and the Mucosal B Cell Miguel A. Park, MD Cathryn R. Nagler, PhD Marriott South Tower, Level 3, Del Mar Duane R. Wesemann, MD PhD Upon completion of this session, participants should be able to: Discuss the different Marriott South Tower, Level 4, Catalina components of the penicillin skin test; Discuss how the different components of the Upon completion of this session, participants should be able to: Discuss how commensal penicillin skin test affect the negative predictive value; Discuss the role of oral challenges organisms and dietary antigens may shape the pre-immune antibody repertoire; Review to penicillin and/or amoxicillin in the evaluation of penicillin allergy. the known mechanisms underlying immune tolerance to gut luminal antigens; Describe the mechanisms regulating antibody affinity maturation and IgH class switch recombina- 2509 Performance of Oral Food Challenges in the tion to IgE. O"ce Setting 2515 : Regulatory Lipid Mediators S. Allan Bock, MD FAAAAI Darryl C. Zeldin, MD Justin M. Skripak, MD Weisong Zhou, PhD Marriott South Tower, Level 3, Miramar Marriott South Tower, Level 4, Coronado Upon completion of this session, participants should be able to: Describe and perform Upon completion of this session, participants should be able to: Define the role of food challenges in their own practices; Review the practical aspects of how to carry out a prostaglandins in vascular remodeling and allergic lung inflammation; Describe the role typical food challenge in the office; Discuss how to select patients for extensively heated of prostaglandins in regulating T cell differentiation and function; Describe the role of milk and egg challenges and how to perform those challenges. prostaglandins on allergen-induced immune tolerance.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

44 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Pro/Con Debate Pro/Con Debate 2521 NHLBI Guideline Adherence Leads to 2524 The Microbiome is Important in Asthma Improvements in Asthma Outcomes in Medical 12:30 to 1:30 pm Center Homes Convention Center, Upper Level, Ballroom 6CF Credit: 1.00 CME / 1.20 CE Programmed by the AAAAI and JCAAI. Honored through an educational Moderator: R. Stokes Peebles, Jr., MD FAAAAI grant from Robert J. Becker, MD, Joint Council of Allergy, Asthma and Immunology Memorial Lectureship Fund. Pro 12:30 to 1:30 pm A. Boushey, MD FAAAAI Convention Center, Mezzanine Level, Room 15AB Con Credit: 1.00 CME / 1.20 CE Thomas A.E. Platts-Mills, MD PhD FAAAAI Moderator: Tao T. Le, MD MHS FAAAAI Upon completion of this session, participants should be able to: Define the human micro- biome; Discuss the relevance of the human microbiome to allergic disease, particularly as Pro it relates to asthma; Discuss possible alterations to the microbiome that might be useful Richard W. Honsinger, MD MACP FAAAAI in asthma therapy. Con Harvey L. Leo, MD FAAAAI Pro/Con Debate Upon completion of this session, participants should be able to: Describe the role of quality measures in the development of ACA parameters; Identify limitations in guideline develop- 2525 Biopsy is Necessary for Follow-up of EoE ments for chronic diseases like asthma; Develop novel ideas to promote the expertise of 12:30 to 1:30 pm allergy/immunology’s role in active population based management of an important chronic Convention Center, Upper Level, Ballroom 6DE disease. Credit: 1.00 CME / 1.20 CE Moderator: Katrina Jane Allen, MD PhD FAAAAI Pro/Con Debate Pro 2522 Bronchial Thermoplasty Has a Role in Severe Jonathan M. Spergel, MD PhD FAAAAI Asthma Management Con 12:30 to 1:30 pm Mirna Chehade, MD MPH Convention Center, Upper Level, Ballroom 6A Upon completion of this session, participants should be able to: List the arguments sup- Credit: 1.00 CME / 1.20 CE porting the assertion that endoscopy is necessary for monitoring EoE; Discuss the argu- ments suggesting that you can follow EoE patients by symptoms; Discuss the relevance of Moderator: Mark F. Sands, MD FAAAAI endoscopies and symptom scores in evaluating and managing patients with esophageal Pro eosinophilia. Mario Castro, MD MPH Con Pro/Con Debate William J. Calhoun, MD FAAAAI 2526 Bone Marrow Biopsy is Indicated in Idiopathic Upon completion of this session, participants should be able to: Recognize the risk and benefit of bronchial thermoplasty (BT) in asthma management; Describe the indications Anaphylaxis and contraindications for BT; Describe the outcomes of major clinical trials for BT. 12:30 to 1:30 pm Convention Center, Upper Level, Room 11AB Pro/Con Debate Credit: 1.00 CME / 1.20 CE 2523 Component Resolved Diagnosis Can Predict Moderator: Phillip L. Lieberman, MD FAAAAI Pro Anaphylactic Reactions to Mariana C. Castells, MD PhD FAAAAI 12:30 to 1:30 pm Con Convention Center, Upper Level, Ballroom 6B Paul A. Greenberger, MD FAAAAI Credit: 1.00 CME / 1.20 CE Upon completion of this session, participants should be able to: Name the current informa- Moderator: Stacie M. Jones, MD tion related to mast cell activation syndrome and idiopathic anaphylaxis; Discuss the Pro primary and secondary triggers of mast cell activation syndrome and anaphylaxis; List the Joerg R. Kleine-Tebbe, MD FAAAAI current treatment guidelines of mast cell activation syndrome and idiopathic anaphylaxis. Con Anna H. Nowak-Wegrzyn, MD FAAAAI Upon completion of this session, participants should be able to: Describe the significance of molecular testing as an indicator for food allergen challenge.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 45 SATURDAY, MARCH 1

Pro/Con Debate Oral Abstract 2527 All Patients with Recurrent Sinus Infections 2602 Mechanisms and Immunotherapy Should be Screened for Immunodeciencies 2:00 to 3:15 pm 12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6CF Convention Center, Upper Level, Room 30ABCDE Credit: 1.25 CME / 1.50 CE Credit: 1.00 CME / 1.20 CE Moderator: Ricardo U. Sorensen, MD Moderator: John M. Routes, MD FAAAAI 2:00 The Utility Of Anti-Pneumococcal Antibody Measurement Pro In Patients With Primary Immunodeficiency Receiving Vincent R. Bonagura, MD FAAAAI Immunoglobulin Con Stephen Jolles Todd T. Kingdom, MD 2:15 Diagnostic Immunization With Bacteriophage ΦX 174 Upon completion of this session, participants should be able to: List the differential In Patients With Common Variable Immunodeficiency/ diagnosis of recurrent or chronic sinusitis in adults; Identify appropriate immunodeficiency Hypogammaglobulinemia screening measures in recurrent/chronic sinusitis and patients that would benefit from Lauren Smith, MD screening. 2:30 Immunochip Study Reveals Regions On 2 and 6 May Contribute To The Spectrum Of CVID Oral Abstract Tracy Hwangpo, MD PhD 2601 Novel Genetic Factors in Asthma 2:45 Rule Of Different Memory Cells In Common Variable 2:00 to 3:15 pm Immunodeficiency and Specific Antibody Deficiency Convention Center, Upper Level, Ballroom 6A Amer M. Khojah, MD Credit: 1.25 CME / 1.50 CE 3:00 Evaluation of a Novel Missense Activation-Induced Deaminase Moderator: Paula L. Busse, MD FAAAAI AID in a Child with Hyper IgM Syndrome: Is it a 2:00 IL-33 and IL1RL1 Single Nucleotide Polymorphisms and Their Pathogenic Mutation? Association With Asthma Among Puerto Ricans Ottavia M. Delmonte, MD Javier A. Mendez, MD Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. 2:15 Genetic Effect Of Single-Nucleotide Polymorphisms In The PPARGC1B Gene On Airway Hyperreactivity In Asthmatic Patients Oral Abstract Jong-Sook Park, MD 2:30 Polymorphisms In IL10, TGFB, TLR4, TLR8 and ADBR2 Genes 2603 Asthma Environmental Risk Factors and Resulted Associated To Asthma In Brazilian Family Trio Study Infections Isabel Ruguê Genov, MD 2:00 to 3:15 pm 2:45 Genetic Variation Along The Histamine Pathway In Children With Convention Center, Mezzanine Level, Room 14AB Allergic Vs. Non-Allergic Asthma Credit: 1.25 CME / 1.50 CE Sara Anvari, MD Moderator: Daniel Elkayam, MD 3:00 Association Of Polymorphism At The CD14 Promoter (CD14- 2:00 Surfactant Protein A (SP-A) Reduces Human Rhinovirus 16 C159T) With Atopic and Non-Atopic Asthma In Adults From (RV16)-Induced Inflammatory Responses In Bronchial Epithelial Crimea, Ukraine Cells and Inhibits Viral Replication In H1-HeLa Cells Yuri Bisyuk Sasipa Tanyaratsrisakul, PhD Upon completion of this session, participants should be able to discuss recent research 2:15 The Home Microbiome and Childhood Asthma developments in the field of allergy/immunology. Christina E. Ciaccio, MD FAAAAI 2:30 Effect Of Prenatal Antioxidant Intake On Infants’ Respiratory Infection Eun Lee 2:45 Epidermal Growth Factor Receptor (EGFR) Mediates Cell Fusion and Infectivity Of Respiratory Syncytial Virus (RSV) Sujin Lee 3:00 Cluster Analysis Of An Inner-City Cohort Of Infant Wheezers Monica B. Reddy, MD Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

46 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Oral Abstract Oral Abstract 2604 Atopic Dermatitis 2606 Local Allergic Rhinitis and Non-Allergic Rhinitis 2:00 to 3:15 pm 2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6B Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: Lisa A. Beck, MD FAAAAI Moderator: Joaquim Mullol, MD PhD FAAAAI Peck G. Ong, MD FAAAAI 2:00 The Nasal NO Response To External Acoustic Energy: A Pilot 2:00 A Randomized, Multi-Center, NIH/NIAID Funded Study To Assess Study The Immunogenicity Of Fluzone® Intradermal and Intramuscular Dennis Shusterman, MD MPH Vaccines In Atopic Dermatitis 2:15 Flagellin/Toll-Like Receptor 5 Induces Interleukin-17C In Human Donald Y.M. Leung, MD PhD FAAAAI Nasal Epithelia 2:15 Which Infants With Eczema Are At Risk Of Food Allergy? Results Hyun Jin Min From A Population Based Study 2:30 Phenotyping Non-Allergic and Local Allergic Rhinitis Jana K. Eckert, PhD Carmen Rondon, MD PhD 2:30 Exome Chip Genotyping Reveals Association With PDE4C and 2:45 Role Of Basophil Activation Test For Identifying Subjects With Atopic Dermatitis In Populations Of European and African Descent Local Allergic Rhinitis Nicholas M. Rafaels Paloma Campo, MD PhD 2:45 Exploring a Role for Laminin Proteins in the Pathogenesis of 3:00 Does Serum Leptin Differ Between Patients With Rhinitis Of Atopic Dermatitis Allergic Vs Nonallergic Aetiology? Erin J. Klaffky, MD PhD Ayse Fusun Kalpaklioglu, MD 3:00 Thymic Stromal Lymphopoietin and Interleukin-33 Promote Skin Upon completion of this session, participants should be able to discuss recent research Inflammation and Containment Of Vaccinia Virus In A Mouse developments in the field of allergy/immunology. Model Of Atopic Dermatitis Michiko K. Oyoshi, PhD MSc Oral Abstract Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. 2607 Mechanisms of Steroid and Arachidonic Acid Pathways in Allergic Disease Oral Abstract 2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 16AB 2605 Health Disparities Credit: 1.25 CME / 1.50 CE 2:00 to 3:15 pm Moderators: Larry Borish, MD FAAAAI Convention Center, Upper Level, Room 1AB Dawn C. Newcomb Baker, PhD Credit: 1.25 CME / 1.50 CE 2:00 LTC4, But Not LTD4 Or LTE4, Activates Platelets Through a Moderators: Melody C. Carter, MD CysLT2R and P2Y12 Receptor-Dependent Pathway Princess U. Ogbogu, MD FAAAAI Joshua A. Boyce, MD FAAAAI 2:00 What Really Happens In The Home: The Medication Environment 2:15 Predictors Of Response To Glucocorticoids In Hypereosinophilic Of Urban, Minority Youth Syndromes Molly Martin, MD MAPP Paneez Khoury, MD 2:15 Young, African American Adults With Asthma: What Matters To 2:30 Differential Proteomic Analysis Of From Patients Them? With Glucocorticoid Responsive Or Resistant Hypereosinophilic Aimee L. Speck, MD Syndrome 2:30 Language Disparities Among Minority Patients with Poor Asthma Konrad Pazdrak, MD PhD Control 2:45 Glucocorticoid Receptor-â Up-Regulation In C57BL/6 Diet- Jose R. -Buxo, MD Induced Obese Mice With House Dust Mite-Mediated Asthma 2:45 Race/Ethnicity and SES Are Predictors Of Allergic Sensitization To Jennifer Diaz, MD Environmental and Food Allergens 3:00 Reduced EP2 Receptor Expression Accounts For E2 Amina Abdeldaim, MD Resistance In Nasal Fibroblasts From Patients With Aspirin 3:00 Unrecognized Allergic Rhinoconjunctivitis and Allergic Exacerbated Respiratory Disease; Possible Role For Histone Sensitization Among Latino Youth (GALA II Study) Acetylation In Control Of EP2 Receptor Expression Ulysses Burley, MPH Katherine N. Cahill, MD Upon completion of this session, participants should be able to discuss recent research Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. developments in the field of allergy/immunology.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 47 SATURDAY, MARCH 1

Symposium Allied Health Workshop 2611 SLIT: Implementation in Your Practice 2623 ICD-10CM: Dispelling the Fear 2:00 to 3:15 pm 2:00 to 3:15 pm Convention Center, Ground Level, Exhibit Hall A Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE A recording of this session will be available online free of charge to Moderator: Joan E. Hawkins registered attendees following the Annual Meeting. Teresa Thompson, CPC CMSCS CCC Moderators: Désirée E.S. Larenas Linnemann, MD FAAAAI 2:45 Question & Answer Michael S. Tankersley, MD FAAAAI Upon completion of this session, participants should be able to: Identify the documentation 2:00 Therapeutic Mechanisms of SLIT requirements for the ICD-10CM system; Review the guidelines for choosing the correct Stephen R. Durham, MA MD FRCP diagnosis code for ICD-10; Discuss the timelines and the effects on the entire allergy 2:20 SLIT Approval Trials in the U.S. practice. Thomas B. Casale, MD FAAAAI Allied Health Symposium 2:40 SLIT in Practice: The Nuts and the Bolts of Using it Linda Cox, MD FAAAAI 2624 Data Management: Taking Your Data from 3:00 Question & Answer Collection to Analysis Upon completion of this session, participants should be able to: Review how SLIT works; 2:00 to 3:15 pm Discuss the results of pivotal SLIT clinical trials; Describe how to use SLIT in practice. Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Allied Health Workshop Moderator: Patrick J. Lenehan, MD 2621 Patient Safety in Allergy Practices: Is it an Issue? 2:00 Data Collection: The First Part of a Long Process 2:00 to 3:15 pm Patrick J. Lenehan, MD Marriott North Tower, Lobby Level, Marriott Hall Salon 1 2:20 Data Cleaning: Reviewing and Reflecting on Study Variables Credit: 1.25 CME / 1.50 CE Charles Aloe, MPH Moderator: John D. Milewski, Med. Admin. 2:40 Data Analysis: Identifying the True Message 2:00 Malpractice: Risk Assessment Jean Curtin-Brosnan, MA Donald W. Aaronson, MD FAAAAI 3:00 Question & Answer 2:30 Question & Answer Upon completion of this session, participants should be able to: Discuss strategies for col- Upon completion of this session, participants should be able to: Identify potential causes of lecting and storing data completely and accurately; Describe the process of cleaning data patient injury due to allergy care; List actions that can prevent patient injury in an allergy and preparing it for analysis; Identify how changes in data can affect analytical results. practice; Discuss the risks of allergy immunotherapy and how to design practices that will reduce medical errors related to allergen immunotherapy that result in patient injury.

Allied Health Symposium 2622 Taking a Food Allergy History for the Advanced Practice Provider: The Key to Diagnosis 2:00 to 3:15 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Credit: 1.25 CME / 1.50 CE Moderator: Pamela H. Steele, MSN CPNP AE-C 2:00 Obtaining a Complete and Concise Food Allergy History from Your Patients Maria G. Crain, CPNP AE-C 2:30 Interpreting the History to Guide Your Use of Diagnostic Testing Katie J. Atkinson, RN CFNP 3:00 Question & Answer Upon completion of this session, participants should be able to: Describe a complete food allergy history; Discuss a concise diet history; Interpret patient information to guide testing.

48 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Allied Health Workshop Keynote 2625 Allied Health Workshop: Travel Scholarship 2701 Genomic and Wireless Digital Innovation: Award Recipients Reshaping the Future of Medicine 2:00 to 3:15 pm 3:30 to 4:30 pm Marriott North Tower, Lobby Level, Atlanta Convention Center, Ground Level, Exhibit Hall A Credit: 1.25 CME / 1.50 CE Credit: 1.00 CME / 1.20 CE Moderator: Stephen J. McGeady, MD FAAAAI Moderator: Stuart L. Abramson, MD PhD FAAAAI 2:00 Case Study of a Successful Asthma Network Eric J. Topol, MD Karen L. Meyerson, MSN FNP-C AE-C Cardiologist, Scripps La Jolla, California; Professor of Genomics at 2:05 AsthmaCare Partners Program the Scripps Research Institute and Chief Academic Officer of Scripps Julie A. Kuhn, MSW Health; and Editor-in-Chief at Medscape 2:10 Patient Satisfaction Surveys (Research) Upon completion of this session, participants should be able to describe how genomics Diane G. Ananos, RN and digital technologies can be utilized in the development and implementation of medical management plans. 2:15 Five Years of FOIT (Food Oral Immunotherapy) in Private Practice Angela Hague, PA-C Q & A Workshop 2:20 Developing Support Groups for Patients with EGID Raquel Z. Durban, MS RD LDN 2801 The In!uence of Bisphenol A and Phthalates 2:25 Bridging the Gap: Gaps in the World of Food Protein Entercolitis (Xenoestrogens) on the Development of Asthma Fallon Schultz, MSW LCSW CAM and Allergy in Children and Adults: What’s Known 2:30 Understanding Barriers and Support in Asthma Management in and What’s Real? School Age Children 4:45 to 6:00 pm Helena Azzi, DNP FNP-BC AE-C Convention Center, Upper Level, Room 1AB 2:35 Indentifying Dietary Interventions in EoE Credit: 1.25 CME / 1.50 CE Anna C. Sprunger, PA-C Moderator: Leslie C. Grammer, MD FAAAAI 2:40 Strengthening Physicians' Ability to Convey Information to 4:45 How Are We Exposed to Bisphenol A and Phthalates in Our Patients Immediate and Regional Environments? Edward M. Horowitz, BA Randall M. Goldblum, MD 2:45 Effietive Program Planning Program Workshop for Asthma 5:00 What Can Basic Research Teach Us About the Effects of Educators Xenoestrogens on Allergy and Asthma? Margaret J. McCormick, MS RN Terumi Midoro-Horiuti, MD PhD FAAAAI 2:50 Surprising Benefits of Omalizumab in a Patient with Mixed 5:15 What Have We Observed About the Effects of Xenoestrogens on Disease Asthma/COPD A Case Study in Knoxville, Tennessee the Development of Childhood and Adult Asthma and Allergy? Laura E. Odom, MSN FNP Rachel L. Miller, MD FAAAAI 2:55 Question & Answer 5:30 Question & Answer Upon completion of this session, participants should be able to: Develop an appreciation Upon completion of this session, participants should be able to: Define the environmen- for the activities of Allied Health members that contribute to the care of patients; Identify tal sources of chemicals with estrogen properties such as bisphenol A and phthalates; effective patient care strategies that can be implemented into the allergy/immunology Summarize the research demonstrating the effects of xenoestrogens on the allergic and practice; Develop professional networks within Allied Health. asthmatic phenotype; Describe the epidemiology that associates xenoestrogen exposures and the development of asthma and allergy in children and adults.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 49 SATURDAY, MARCH 1

Hands-On Workshop Q & A Workshop 2802 EMR Roundtable: What Are Allergists Using? 2804 The Safety of Asthma Medications During 4:45 to 6:00 pm Pregnancy: An Update Convention Center, Upper Level, Room 2 4:45 to 6:00 pm Pre-registration and ticket required. Fee: $50. Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Tao T. Le, MD MHS FAAAAI Moderator: Michael Schatz, MD MS FAAAAI Practice Fusion 4:45 The Safety of Asthma Medications During Pregnancy: VAMPSS Dana V. Wallace, MD FAAAAI Prospective Cohort Data GE Centricity Christina Chambers, PhD MPH A. Sean McKnight, MD FAAAAI 5:00 The Safety of Asthma Medications During Pregnancy: VAMPSS Allscripts Case-Control Data Melinda M. Rathkopf, MD FAAAAI Allen A. Mitchell, MD EPIC 5:15 A Synthesis of Data on the Safety of Asthma Medications During Ves Dimov, MD Pregnancy Meditab-IMS Jennifer A. Namazy, MD FAAAAI Richard L. Wasserman, MD PhD FAAAAI 5:30 Question & Answer NextGen Upon completion of this session, participants should be able to: Evaluate the recent Robert Anolik, MD FAAAAI VAMPSS prospective cohort data on the safety of asthma medications in pregnancy; Review the recent VAMPSS case-control data on the safety of asthma medications in ModuleMD pregnancy; Discuss current information on the gestational safety of asthma medications Instructor to be announced. to the clinical care of pregnant patients with asthma. eClinical Works Reception immediately following the session with the VAMPSS Investigative Hugh H. Windom, MD FAAAAI Team. Rosch Nathaniel D. Hare, MD FAAAAI Q & A Workshop Upon completion of this session, participants should be able to: Discuss the challenges al- lergists face in EMR selection; Discuss tips on EMR selection and implementation specific 2805 AAP: Hot Topics in Pediatric Allergy and to the practicing allergist; Review specific EMRs with allergists using them in practice. Immunology 4:45 to 6:00 pm Problem-Based Learning Workshop Convention Center, Upper Level, Ballroom 6A 2803 A Child with Severe Atopic Dermatitis Credit: 1.25 CME / 1.50 CE Moderator: Todd A. Mahr, MD FAAAAI 4:45 to 6:00 pm 4:45 Allergic Respiratory Disease Convention Center, Upper Level, Room 3 Chitra Dinakar, MD FAAAAI Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE 5:00 Food and Drug Allergies PBL Facilitator: Stanley M. Fineman, MD MBA FAAAAI Brian P. Vickery, MD FAAAAI Content Lecturer: Mark Boguniewicz, MD FAAAAI 5:15 Immunologic Disorders Upon completion of this session, participants should be able to: Discuss the differential Thomas A. Fleisher, MD FAAAAI diagnosis of severe atopic dermatitis; Assess food allergy as a co-morbid condition in this 5:30 Question & Answer patient; Summarize cutting-edge literature on state of the art skin therapy in refractory Upon completion of this session, participants should be able to: Describe the latest devel- atopic dermatitis. opments in pediatric allergy and immunology; Discuss how these might impact the care of pediatric patients with respiratory allergic disease, food and drug allergy and immunologic disorders. Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

50 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Q & A Workshop Q & A Workshop 2806 Who’s on First? Primary Immunode!ciency, 2809 Update in Occupational Allergy: A Focus on the Autoimmune Disease or Immune Modulation Skin, Nose, and the Young Worker 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6B Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Ramsay L. Fuleihan, MD Moderator: Susan M. Tarlo, MBBS FAAAAI 4:45 Autoimmune Disease with Primary and Secondary Failure of 4:45 Skin Prick Testing in the Diagnosis of Occupational Type I Tolerance Allergies Speaker to be announced. Joaquin Sastre, MD PhD FAAAAI 5:00 Infectious Complications of Immune Modulation 5:00 Occupational Rhinitis Christina C. Price, MD Santiago Quirce, MD PhD 5:15 Monitoring and Supporting Immune Function After 5:15 Prevention of Work-Related Respiratory Allergies in Young Immunomodulation Workers Vibeke Strand, MD André Cartier, MD FAAAAI 5:30 Question & Answer 5:30 Question & Answer Upon completion of this session, participants should be able to: Discuss how autoimmu- Upon completion of this session, participants should be able to: Review the pros and nity arises in the setting of primary and secondary immunodeficiency; Review potential cons of skin testing for occupational allergens and recent advances in occupational skin infectious sequelae arising from immunomodulation; Describe how to monitor and support allergy; Identify the range of exposures causing occupational rhinitis and tools for inves- immune function after immune compromise due to immunomodulator therapy. tigation; Discuss how to approach adolescents and young adults at risk of work-related allergic responses. Q & A Workshop Q & A Workshop 2807 Di#cult Drug Allergy Cases: Case-Based Discussions 2810 Molecular Pathogenesis of Aspirin Intolerance 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6CF Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Rebecca S. Gruchalla, MD PhD FAAAAI Moderator: Robert P. Schleimer, PhD FAAAAI 4:45 Management of Patients with Multiple Drug Allergies 4:45 Prostaglandin E2 Resistance: An Explanation for Dysregulation of Roland Solensky, MD FAAAAI in AERD Tanya M. Laidlaw, MD FAAAAI 5:00 Perioperative Anaphylaxis and Advice for Patients Needing Further Surgery 5:00 Chronic Rhinosinusitis and Disturbed Microbial Homeostasis Aleena Banerji, MD Susan V. Lynch, PhD 5:15 Determine When Skin Testing, Test Doses and Desensitization are 5:15 The Surprising Role of Interferon Gamma in AERD Appropriate Larry Borish, MD FAAAAI David A. Khan, MD FAAAAI 5:30 Question & Answer 5:30 Question & Answer Upon completion of this session, participants should be able to: Identify the molecular control mechanisms of the 5-lipoxygenase enzyme; Identify the potential contribution Upon completion of this session, participants should be able to: Explain management of from the perturbed microbiome; Discuss the potential role of inteferon gamma in AERD. patients with multiple drug allergies; Describe perioperative anaphylaxis: diagnosis, evalu- ation and management; Identify the role for skin testing, test dose and desensitization. Panel Discussion Workshop Panel Discussion Workshop 2811 Experimental Models of Allergic Rhinitis: 2808 Thriving and Surviving in the Evolving Healthcare Evaluation and Utilization System: 2014 JCAAI Update 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Room 5AB Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Fuad M. Baroody, MD FAAAAI Moderator: J. Allen Meadows, MD FAAAAI Panelists: Panelists: Anne K. Ellis, MD MSc FAAAAI Donald W. Aaronson, MD FAAAAI Robert M. Naclerio, MD FAAAAI Gary N. Gross, MD FAAAAI Martin Wagenmann, MD FAAAAI Richard W. Honsinger, MD MACP FAAAAI Upon completion of this session, participants should be able to: Describe the commonly used methodologies utilized in environmental exposure unit-type studies of allergic Upon completion of this session, participants should be able to: List strategies for rhinitis; Describe the most commonly used methodologies for experimental nasal allergen positioning their practices for success in the changing healthcare arena; Describe the challenge in the investigation of allergic rhinitis; List the advantages and disadvantages of changing allergy CPT codes, ICD-10 changes and other new coding developments; both experimental models pertaining to the study of allergic rhinitis. Discuss the requirements for compliance with federal regulations, including penalties for non-compliance.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 51 SATURDAY, MARCH 1

Q & A Workshop Q & A Workshop 2812 Safety Challenges with Allergen Immunotherapy 2814 ABAI: Help Me Help You Meet MOC Requirements 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 14AB Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Matthew A. Rank, MD FAAAAI Moderator: Stephen I. Wasserman, MD FAAAAI 4:45 Allergen Immunotherapy in Patients with Other Special Medical 4:45 What’s New and What Do I Have to Do to Meet MOC Conditions Requirements? Désirée E.S. Larenas Linnemann, MD FAAAAI Rayné Harrison 5:00 Immunotherapy and Medication: Lessons Learned from 5:00 Roadblocks to Meeting MOC Requirements Experience on How to Approach these Patients Sarah Johnson Christopher W. Calabria, MD 5:15 How I Survived Meeting MOC Requirements 5:15 Which Factors Might Enhance Safety of Immunotherapy in Your James M. Tracy, DO FAAAAI Clinic? 5:30 Question & Answer David I. Bernstein, MD FAAAAI Upon completion of this session, participants should be able to: Review the MOC require- 5:30 Question & Answer ments and how to successfully complete them; Demonstrate tips and tricks to completing Upon completion of this session, participants should be able to: Discuss safety experience MOC requirements; Reflect upon the personal experience of a peer who completed MOC with allergen immunotherapy given to patients with a history of cancer, HIV positivity, requirements. hypertension and other underlying medical conditions; Describe problems that might arise theoretically and problems that have been reported with AIT in patients taking certain Q & A Workshop medications (beta-blockers, ACE inhibitors, immunosuppressive drugs, etc.); Recognize factors in an allergy clinic associated with a higher rate of adverse events with AIT and 2815 The Next Step After ICS/LABA recommend actions in their clinics that might augment safety of AIT. 4:45 to 6:00 pm Convention Center, Upper Level, Room 30ABCDE Q & A Workshop Credit: 1.25 CME / 1.50 CE 2813 The Epithelium in Control Moderator: Harold S. Nelson, MD FAAAAI 4:45 The Case for Anti-Cholinergics 4:45 to 6:00 pm Brian J. Lipworth, MD Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE 5:00 The Case for Fine Particle ICS Moderator: Angela Haczku, MD PhD FAAAAI Richard J. Martin, MD 4:45 TSLP, Here We Go Again! 5:15 The Case for Omalizumab Steven Ziegler, PhD Thomas B. Casale, MD FAAAAI 5:00 The Importance of IL-25 5:30 Question & Answer Hirohito Kita, MD Upon completion of this session, participants should be able to: List the evidence sup- porting the use of therapy in refractory asthma; Review the evidence 5:15 Epithelial and Dendritic Cell-Derived IL-33 in Control of Allergic supporting the use of a small particle ICS over conventional ICS molecules; Discuss recent Disease evidence supporting the use of omalizumab treatment in difficult asthma. Anne Sperling, PhD 5:30 Question & Answer Problem-Based Learning Workshop Upon completion of this session, participants should be able to: Describe novel mecha- nisms through which epithelial TSLP drives allergic disease; Discuss the mechanism 2816 Controversies in a Patient with Insect Sting through which epithelial derived IL-25 drives allergic disease; Discuss how the epithelium Anaphylaxis through IL-1a is able to drive allergic disease. 4:45 to 6:00 pm Convention Center, Upper Level, Room 31C Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Ray S. Davis, MD FAAAAI Annual Meeting Workshops Content Lecturer: David B.K. Golden, MD FAAAAI Upon completion of this session, participants should be able to: Discuss a case vignette Programmed by the AAAAI. Annual Meeting Workshops funded of a patient with stinging insect anaphylaxis; Apply the latest Practice Parameters in the through an educational grant from Merck. management of a challenging patient with insect venom anaphylaxis; Determine criteria for when to discontinue venom immunotherapy.

52 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SATURDAY, MARCH 1

Allied Health Workshop Allied Health Workshop 2821 Anaphylaxis: Advancing Pro!ciency in 2824 Myth Busters: Using Evidence-Based Medicine Recognition, Management and Risk Reduction to Dispel Your Patient’s Allergy-Related Urban 4:45 to 6:00 pm Myths Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 4:45 to 6:00 pm Pre-registration and ticket required. No fee. Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Dee Mallam, RN AE-C Moderator: Jeanette L. Arnold, MSN RN C-FNP 4:45 Anaphylaxis: Recognition and Treatment David R. Stukus, MD FAAAAI Gregory M. Metz, MD 5:30 Question & Answer 5:00 Anaphylaxis: Risk Reduction Strategies Upon completion of this session, participants should be able to: Discuss commonly held Karen L. Gregory, DNP APRN-BC RRT AE-C misconceptions in the field of allergy/immunology; Analyze the evidence that refutes these 5:15 Hands-On Instruction commonly held misconceptions; Describe information that can be utilized in clinical prac- tice to address frequently asked questions received from referring providers and patients. Upon completion of this session, participants should be able to: Discuss the criteria for anaphylaxis; Identify signs and symptoms of anaphylaxis and understand appropriate treatment; Describe risk factors for anaphylaxis and implement risk reduction strategies. Allied Health Workshop 2825 Managing the Complexities of the Food Protein- Allied Health Workshop Induced Enterocolitis Syndrome Diet 2822 Paths to Empowerment: Motivation and 4:45 to 6:00 pm Cost-E$ective Incentives in an Economically Marriott North Tower, Lobby Level, Atlanta Challenging Environment Credit: 1.25 CME / 1.50 CE Moderator: G. Lynn Christie, MS RD 4:45 to 6:00 pm Kathryn E. Grimshaw, PhD RD Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Carina Venter, PhD RD Credit: 1.25 CME / 1.50 CE Moderator: John D. Milewski, Med. Admin. 5:25 Question & Answer Jeanette Booker Upon completion of this session, participants should be able to: Identify foods commonly associated with FPIES; Describe the typical feeding progression in infancy and how to 5:30 Question & Answer provide appropriate foods to promote feeding skill development with a very limited diet; Upon completion of this session, participants should be able to: Identify how to assess Discuss specific nutritional risks associated with a limited solid foods diet in infancy and level of motivation in current employees; Discuss how to improve motivation and increase how to prevent/correct deficiencies in these diets. productivity; Outline how to change the culture in their practices and look at alternative incentives that are cost effective and reap positive results. New Allergist/Immunologist Assembly Business Meeting Allied Health Workshop and Reception 4:45 to 6:15 pm 2823 Performing a Practice Assessment Convention Center, Upper Level, Room 31AB 4:45 to 6:00 pm The AAAAI invites all new allergy/immunology specialists to attend this Marriott North Tower, Lobby Level, Marriott Hall Salon 1 business meeting and reception. Credit: 1.25 CME / 1.50 CE Moderator: Joan E. Hawkins Chrysalis Project Reception Thomas J. Derrico 6:00 to 7:00 pm 5:30 Question & Answer Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Upon completion of this session, participants should be able to: Discuss the importance Private reception open to Chrysalis project participants, mentors, of a periodic assessment of their practices operational and financial performance; Identify key areas for consideration in performing an assessment; Describe sources of data from faculty, and the Program Directors Assembly. within their practices and how to obtain the data. The Allergy, Asthma & Immunology Education and Research Organization (ARTrust™) “First Class Event”

7:00 to 10:00 pm San Diego Air & Space Museum All AAAAI members, delegates and guests are invited to attend this Saturday evening event. See page 13 for more information.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 53 Save the Date

AAAAI Annual Meeting 2015 February 20-24 Houston Texas American Academy of Allergy, Asthma & Immunology SUNDAY, MARCH 2

Seminars 3007 Environmental Microbiomes 7:00 to 8:00 am Christina E. Ciaccio, MD FAAAAI Pre-registration and ticket required. Fee: $40. Continental breakfast Brett J. Green, PhD included. Sessions and meals are limited to 30 people. Marriott South Tower, Level 3, Cardiff Credit: 1.00 CME / 1.20 CE Upon completion of this session, participants should be able to: Explore the human micro- biome and allergic disease; Discuss the normal indoor microbiome and factors that cause 3001 Treating the Patient with Di#cult to Treat alterations in the typical structure. Exercise-Induced Asthma: Novel Therapies for 3008 Medical Management of Eosinophilic Esophagitis Exercise-Induced Bronchoconstriction in Adults Matteo W. Bonini, MD Mark Holbreich, MD FAAAAI William W. Storms, MD FAAAAI Javed Sheikh, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon D Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Outline current therapies Upon completion of this session, participants should be able to: Show the appropriate use for exercise-induced bronchoconstriction and acknowledge that some patients do not re- of diet in EoE management in adults; Demonstrate the different medications and become spond to them; Describe novel therapies for exercise-induced bronchoconstriction; Explain familiar with dose and delivery; Describe the pros and cons of esophegeal dilation in EoE. why beta agonists do not work for all patients with exercise-induced bronchoconstriction. 3009 Mastocytosis Mimics: Cutting Through the Clutter 3002 Use of Cytokine Inhibitors in Severe Asthma Joseph H. Butterfield, MD FAAAAI Jonathan Corren, MD Melody C. Carter, MD Sally E. Wenzel, MD FAAAAI Marriott South Tower, Level 3, Miramar Marriott South Tower, Level 3, Marina Ballroom Salon E Upon completion of this session, participants should be able to: List the criteria for Upon completion of this session, participants should be able to: Review and understand diagnosing systemic mastocytosis; Recognize the variety of mast cell activation disorders the roles that specific cytokines play in asthma; Review trials of various agents (anti-TNF, and the criteria needed for a true diagnosis of mast cell activation syndrome; Describe the anti-IL4, anti-IL13, anti-IL5, anti-IL17, anti-IL9) in asthma; Explore subtypes of asthma differential diagnostic possibilities when faced with a patient with symptoms suggestive of where these agents might best be used. systemic mastocytosis or mast cell activation syndrome. 3003 How Many Eosinophils are Too Many? 3010 Optimizing the Allergist’s Expertise in Asthma Paneez Khoury, MD Adherence Princess U. Ogbogu, MD FAAAAI Bruce G. Bender, PhD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon F L. Keoki Williams, MD MPH FAAAAI Upon completion of this session, participants should be able to: Review the criteria for eosinophilia; Discuss the differential diagnosis of eosinophilia; Review the work-up for an Marriott South Tower, Level 1, Point Loma increased count. Upon completion of this session, participants should be able to: Discuss an appreciation for the prevalence and implications of suboptimal adherence in asthma; Develop clues 3004 Social Media for Allergy/Immunology Practice: which may suggest suboptimal adherence; Discuss strategies to facilitate optimal control- Let’s Do It! ler use in specific asthmatic patients. Sakina S. Bajowala, MD FAAAAI 3011 Is Immunotherapy Getting Safer? Updated Nathaniel D. Hare, MD FAAAAI Information on Various Forms of Immunotherapy Marriott South Tower, Level 3, Marina Ballroom Salon G and How to Improve Upon completion of this session, participants should be able to: Discuss how to set up a Twitter account and how to use it to connect with patients and colleagues; Discuss how to Tolly Epstein, MD MS set up a Facebook professional page; Describe how to use YouTube to embed and record Michael S. Tankersley, MD FAAAAI videos to maintain an interactive website for your practice. Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Summarize current 3005 Update on Testing for Primary Immunode!ciency evidence regarding the incidence of fatal reactions to SCIT; Critically assess new evidence Diseases characterizing risk factors associated with SCIT anaphylaxis that may be applied to John M. Routes, MD FAAAAI optimize safety protocols; Discuss the necessity of the thirty minute waiting period after Kathleen E. Sullivan, MD PhD FAAAAI SCIT injections. Marriott South Tower, Level 3, Balboa 3012 Clinical Conundrums in Chronic Rhinosinusitis Upon completion of this session, participants should be able to: Review novel testing for Rakesh Chandra, MD recurrent or unusual infections; Discuss genetic testing for primary immunodeficiency Raymond G. Slavin, MD MS FAAAAI diseases; Discuss future testing for primary immunodeficiency. Marriott South Tower, Level 1, Santa Rosa 3006 Let’s Take the Myth-stery Out of Mold Upon completion of this session, participants should be able to: Utilize an evidence-based James J. Anderson, MLT approach to the diagnosis and treatment of chronic rhinosinusitis. Peter J. Pityn, PhD 3013 Understanding How Allergic Responses End: Marriott South Tower, Level 3, Mission Hills The Allergy Resolvome Upon completion of this session, participants should be able to: Provide evidence that the risk of mold is often overstated, misstated or misunderstood; Learn of the true risk Koichiro Asano, MD presented by mold; Explore issues with mold assessments and everyday mold exposure. Ariel Munitz, PhD Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to: Identify factors involved Annual Meeting Seminars in resolution of inflammation; Review lipid mediators’, IL-10 and endocannabinoids’ mechanism of action in the resolution of inflammation. Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 55 SUNDAY, MARCH 2

3014 Inhibitory Receptors on Allergy E$ector Cells: 3044 Tips on Training School Personnel about Food New Therapeutic Targets Allergies and Anaphylaxis Bruce S. Bochner, MD FAAAAI Sonia C. Mancia, RN Francesca Levi-Schaffer, PhD FAAAAI Humaira Robinson, BSN RN Marriott South Tower, Level 4, Catalina Marriott North Tower, Lobby Level, New York & Orlando Upon completion of this session, participants should be able to: Discuss the mechanisms Upon completion of this session, participants should be able to: Discuss tips on how to of three different inhibitory receptors pertinent for asthma; Describe efforts to therapeuti- train school personnel to recognize and treat anaphylaxis; Review evidence regarding the cally target these receptors. content to include training and the efficacy of such training. 3015 Parasites, Allergy and Asthma Plenary Luisa Karla P. Arruda, MD PhD FAAAAI Thomas A.E. Platts-Mills, MD PhD FAAAAI 3101 Integrated Airways Marriott South Tower, Level 4, Coronado 8:15 to 9:45 am Upon completion of this session, participants should be able to: Review outcomes of Convention Center, Ground Level, Exhibit Hall A clinical trials conducted with parasites to treat patients with asthma or rhinitis; Discuss Credit: 1.50 CME / 1.80 CE epidemiologic studies on parasites, allergy and asthma carried out in different areas of the world and with different populations; Discuss mechanisms by which parasite infection Moderator: Steve N. Georas, MD may influence immune responses underlying allergy and asthma and the role of parasite 8:15 Host Defense, Inflammation and Remodeling in the Upper Airway infections in total and specific IgE. Robert P. Schleimer, PhD FAAAAI 8:45 Barrier Dysfunction in the Lower Airway Allied Health Seminars Donna Davies, BSc PhD 7:00 to 8:00 am 9:15 Asthma Endotypes: The Next Step Towards Personalized Asthma Pre-registration and ticket required. Fee: $10. Sessions are limited to Care 30 people. Sally E. Wenzel, MD FAAAAI Credit: 1.00 CME / 1.20 CE Upon completion of this session, participants should be able to: Discuss the immuno- pathogenesis of barrier dysfunction in chronic rhinosinusitis; Describe the relationship be- 3041 PFT Interpretation: Beyond the FVC tween barrier dysfunction and the immunopathogenesis of asthma; Discuss how asthma Edward O. Corazalla, MS RPFT endotypes are influencing the development of personalized asthma therapy. Marriott North Tower, Lobby Level, Rancho Santa Fe 1 & 2 Upon completion of this session, participants should be able to: Review the effect clinical Posters status has on PFT testing; Develop the ability to interpret difficult spirometry tracings; Interpret PFTs and develop options to modify the asthma care plan. 7:00 am to 6:00 pm Convention Center, Ground Level, Exhibit Hall B 3042 Recurrent Infections: When is a “Little Cold” More Posters on display from 7:00 am to 6:00 pm. Authors present from Than a “Little Cold” 9:45 to 10:45 am. Joseph L. Roberts, MD PhD Credit: No CME / No CE Debra A. Sedlak, MSN CPNP Refer to pages 83 – 158 for abstracts and authors. Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 3201 Bronchoprovocation and Asthma Comorbidities Upon completion of this session, participants should be able to: Develop an appreciation of the multiple presentations of the patient with recurrent infections; Discuss the selection 3202 Biomarkers and Asthma Control I of appropriate testing to determine if the patient has or is evolving to a primary im- munodeficiency diagnosis; Review the appropriate screening test for non-PIDD diagnosis 3203 Atopic Disease Basic Science (autoimmune, endocrine). 3204 T Cell Mediated Immunity 3043 Complementary and Alternative Medicine (CAM): 3205 Asthma Epidemiology, Risk Factors and Public What’s New and What We Need to Know: Taking a Health II History and Providing Guidance on Patients’ Use 3206 Aerobiology II of CAM in Allergy and Asthma 3207 Food Allergy I Maureen George, PhD RN AE-C William S. Silvers, MD FAAAAI 3208 Urticaria Marriott North Tower, Lobby Level, Atlanta & Chicago 3209 Pediatric Population Health Upon completion of this session, participants should be able to: Discuss commonly used CAM for seasonal allergies and asthma; Describe the evidence for saline nasal irriga- 3210 Health Information Technology tion, acupuncture, butterbur, and other CAM in a clinical case; Investigate online 3211 Chronic Rhinosinusitis and Polyps resources for reference, e.g. NCCAM (NIH National Center for Complementary and Alterna- tive Medicine), Natural Comprehensive Database, etc. 3212 Rhinitis 3213 Mechanisms of Lymphocyte Function 3214 Role of Structural Cells in Mechanisms in Health and Disease Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

56 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SUNDAY, MARCH 2

Symposium Symposium 3301 EAACI: Novel Developments 3303 Update of the Allergic Contact Dermatitis Practice in Asthma Exacerbations Parameter: What’s New in 2014? 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6A Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: Cezmi A. Akdis, MD FAAAAI Moderator: H. Henry Li, MD PhD Nikolaos G. Papadopoulos, MD FAAAAI 10:45 Clinical Pearls and Clues in the Assessment of the Patient 10:45 Molecular Mechanisms of Asthma Exacerbations Referred for Evaluation of Contact Dermatitis and Patch Testing Evangelos Andreakos, PhD David I. Bernstein, MD FAAAAI 11:05 Immune Response to Rhinoviruses and Their Link to Asthma 11:05 What are the Most Common Chemical Sensitizers at Home and in Exacerbations the Workplace? Mubeccel Akdis, MD PhD Luz S. Fonacier, MD FAAAAI 11:25 Eicosanoids and Asthma Exacerbations 11:25 Metal Allergy and Implantable Devices Marek Sanak, MD Karin A. Pacheco, MD MSPH FAAAAI 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: List mechanisms underly- Upon completion of this session, participants should be able to: Identify key factors in ing asthma exacerbations; Describe the interaction of respiratory viruses with epithelium, clinical history and patch testing in suspected allergic contact dermatitis; Identify the the immune system and how eicosanoids play a role in the pathogenesis of asthma most frequent contact sensitizers encountered at home and in the workplace; Discuss the exacerbations. relationship between metal hypersensitivity and prosthetic joint failure.

Symposium Symposium 3302 Pathophysiology and Management of Urticaria 3304 Wheezing Episodes in Preschool Children: The and Angioedema Role of Bacterial Pathogens, Treatment of 10:45 am to 12:00 pm Acute Exacerbations and Potential for Asthma Convention Center, Upper Level, Ballroom 6B Prevention Credit: 1.25 CME / 1.50 CE 10:45 am to 12:00 pm Moderator: David R. Weldon, MD FAAAAI Convention Center, Upper Level, Ballroom 6DE 10:45 Pathophysiology of Chronic Urticaria Credit: 1.25 CME / 1.50 CE Thomas B. Casale, MD FAAAAI Moderator: Leonard B. Bacharier, MD FAAAAI 11:05 Diagnostic Evaluation of Patients with Chronic Urticaria/ 10:45 Wheezing Episodes in Preschool Children: Beyond Viral Infections Angioedema: What Does the Evidence Tell Us? Daniel J. Jackson, MD David M. Lang, MD FAAAAI 11:05 Oral as a Treatment of Acute Wheezing Episodes 11:25 Therapy Options for Patients with Anti-Histamine Resistant in Preschool Children: What is the Evidence for the Efficacy of Chronic Urticaria This Treatment? Javed Sheikh, MD FAAAAI Avraham Beigelman, MD MSCI 11:45 Question & Answer 11:25 The Utility of Oral Bacterial Extracts as a Prevention Modality for Upon completion of this session, participants should be able to: Describe updates of Wheezing Episodes and Asthma the pathophysiology of chronic urticaria; Describe cost-effective and evidence-based diagnostic evaluation of patients with chronic urticaria/angioedema; Relate evidence sup- Fernando D. Martinez, MD porting use of therapeutic interventions for patients with -resistant urticaria/ 11:45 Question & Answer angioedema. Upon completion of this session, participants should be able to: Discuss the current evidence of the role of bacterial pathogens in the pathogenesis of wheezing episodes in preschool children; Evaluate whether the current evidence supports the utility of oral corticosteroids as a treatment for acute wheezing episodes in preschool children; Discuss emerging concepts on the utility of immunostimulants for the prevention of wheezing episodes and potentially asthma.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 57 SUNDAY, MARCH 2

Symposium Symposium 3305 Molecular Allergy: From Bench to Bedside 3307 The Emergence of Innate Lymphocyte 10:45 am to 12:00 pm Populations Driving Allergic Disease Convention Center, Upper Level, Room 11AB 10:45 am to 12:00 pm Credit: 1.25 CME / 1.50 CE Convention Center, Mezzanine Level, Room 15AB Moderator: Robert G. Hamilton, PhD D.ABMLI FAAAAI Credit: 1.25 CME / 1.50 CE 10:45 Improved Diagnostics for Food Allergy: Higher Analytical Moderator: Larry Borish, MD FAAAAI Sensitivity and Better Risk Assessment Using Single Molecules 10:45 Innate Properties of IL-5+ “Super-Effector” Th2 Cells Kirsten Beyer, MD Calman Prussin, MD FAAAAI 11:05 Improved Diagnostics for Inhalant Allergy: Addressing Plant 11:05 Type 2 Innate Lymphoid Cell Activation by CysLTs Related Crossreactivity and Multisensitizations with Single Taylor A. Doherty, MD FAAAAI Molecules 11:25 Innate Lymphoid Cells and Invariant Natural Killer T Cells in Joerg R. Kleine-Tebbe, MD FAAAAI Asthma 11:25 Allergenic Molecules in Anaphylactic Reactions: Improved Dale T. Umetsu, MD PhD FAAAAI Differentiation and Analytical Sensitivity 11:45 Question & Answer Markus W. Ollert, MD Upon completion of this session, participants should be able to: Discuss the various innate 11:45 Question & Answer cell populations and their contributions to allergic inflammation and pathogenesis; Identify Upon completion of this session, participants should be able to: Discuss the diagnostic the role of lipid mediators in regulation of adaptive Th2 immunity; Identify the potential value of food components and how they can lead to improved diagnostic answers and roles of innate lymphocytes in allergic disease. advice to the patient; Describe the diagnostic value of inhalant allergen components and how they can lead to improved diagnostic answers and advice to the multi- sensitized Symposium patient; Identify recently identified components from and wasp venom, latex and other protein allergens that facilitate definitive answers in cases of presumed sensitizations and 3308 Closing the Outcome Gap for Women with enhance analytical sensitivity. Asthma : A Tribute to Noreen M. Clark, PhD Symposium 10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB 3306 The Relationship Between Allergies and Credit: 1.25 CME / 1.50 CE Infections Moderator: Georgiana M. Sanders, MD MS FAAAAI 10:45 am to 12:00 pm 10:45 Clinical, Social, and Cultural Factors in Asthma Management Convention Center, Room 14AB by Women and Potential Outcomes from Gender Focused Credit: 1.25 CME / 1.50 CE Interventions Moderator: Dorothy S. Cheung, MD FAAAAI Georgiana M. Sanders, MD MS FAAAAI 10:45 Basophils: Initiators of the Immune Response 11:05 Asthma Management in Women with Multiple Morbidities Caroline L. Sokol, MD PhD Mary Janevic, MPH PhD 11:05 Mast Cells in the Immune Response Against Bacteria 11:25 Special Challenges in Treatment and Self Management for Older Soman N. Abraham, PhD Women with Asthma Alan P. Baptist, MD MPH FAAAAI 11:25 Role of IgE in the Anti-Viral Immune Response Mitchell H. Grayson, MD FAAAAI 11:45 Question & Answer Upon completion of this session, participants should be able to: Describe the range of 11:45 Question & Answer treatment and management challenges and solutions particular to their female asthma Upon completion of this session, participants should be able to: Discuss the ability of patients; Recognize elements of education for female patients that are associated with basophils to present antigen and start an immune response; Describe the data suggesting reduced health care use and symptom burden. that the production of IgE is part of the antiviral immune response; Discuss how mast cells play a role in the clearance of bacterial and viral infections. Allied Health Symposium 3311 Update on Experience Performing Baked Egg and Baked Milk Food Challenges 10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Kim E. Mudd, RN MSN CCRP Teri Holbrook, RN CRNP Hemant P. Sharma, MD MHS FAAAAI Elisabeth S. Stieb, RN BSN AE-C 11:45 Question & Answer Upon completion of this session, participants should be able to: Identify which children can be considered for a food challenge to baked milk and baked egg; Describe the ap- propriate protocol to use in your practice to conduct a baked milk and baked egg food challenge; Discuss how children who pass a baked milk and baked egg food challenge can increase the foods in their diets.

58 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SUNDAY, MARCH 2

Allied Health Workshop Allied Health Oral Abstract Session 3312 Motivational Interviewing Strategies 3520 Allied Health Oral Abstract Luncheon 10:45 am to 12:00 pm 12:15 to 1:30 pm Marriott North Tower, Lobby Level, Rancho Santa Fe 1 & 2 Marriott North Tower, Lobby Level, San Diego Ballroom Salon C Credit: 1.25 CME / 1.50 CE Pre-registration and ticket required. Fee: $40. Box lunch included. Moderator: Michael S. Tankersley, MD FAAAAI Credit: 1.25 CME / 1.50 CE Beth A. Allison, NP Moderator: Debra A. Sedlak, MSN CPNP 11:30 Question & Answer 12:15 Clinical Efficacy Of Subcutaneous and Sublingual Immunotherapy Upon completion of this session, participants should be able to: Discuss the role of In Asthma and Rhinitis Children Sensitized To House Dust Mite ambivalence in behavior change; Describe strategies for dealing with patient resistance; Min-Ju Kim Review brief motivational interviewing strategies to incorporate into practice. 12:30 A Patient-Reported Symptom-Based Predictor Of Objective Sinus Inflammation Allied Health Workshop Alcina K. Lidder, BA 3313 Immunotherapy Guideline Update: Third Edition 12:45 Healthcare Providers’ Perception vs. Reality In Patient Concerns and USP 797 Compliance About Starting Subcutaneous Immunoglobulin 10:45 am to 12:00 pm Carla M. Duff, CPNP MSN Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 1:00 Anaphylaxis During Obstetric Surgery In Latex Allergic Patients Credit: 1.25 CME / 1.50 CE Nana Jinjolava, MD Panelists 1:15 The Impact Of Legislation On Illinois School Nurses Cheryl Koff Bernstein, RN BSN CCRC Christine Szychlinski, APN CPNP Michael R. Nelson, MD PhD FAAAAI Upon completion of this session, participants should be able to discuss the diversity in Upon completion of this session, participants should be able to: Discuss the requirements care provided to the allergy and immunology patient population. and importance of becoming compliant with USP chapter 797; Describe the compliance requirements for allergen extract preparation according to the USP chapter 797 and Interest Section Forum immunotherapy Practice Parameters Guidelines Third Edition Update; Identify practical approaches for implementation of the guidelines. 3521 ADT: Hot Issues in Asthma 12:30 to 2:30 pm Allied Health Workshop Convention Center, Upper Level, Room 5AB Pre-registration and ticket required. No fee. Box lunch included. Bring 3314 Childhood Asthma and Obesity: What Do We your mobile device to participate. Know? What Can We Do? Credit: 1.25 CME / 1.50 CE 10:45 am to 12:00 pm Moderator: Timothy J. Craig, DO FAAAAI Marriott North Tower, Lobby Level, Atlanta & Chicago 12:30 Lunch Credit: 1.25 CME / 1.50 CE 12:35 Business Meeting Moderator: Stephen J. McGeady, MD FAAAAI Timothy J. Craig, DO FAAAAI Anne E. Borgmeyer, MSN RN CPNP AE-C 1:05 Question & Answer Carina Venter, PhD RD 1:15 Why are Microbiomes Important in Asthma? 11:25 Question & Answer Homer A. Boushey, MD FAAAAI Upon completion of this session, participants should be able to: Outline the relationship between asthma and obesity; Review current guidelines for the management of childhood 1:45 Update on Newer Approved Therapies and New Uses of Old Drugs obesity and asthma; Discuss barriers to adherence for obese children with asthma and for Asthma their families. William W. Busse, MD FAAAAI 2:15 Question & Answer Allied Health Workshop Upon completion of this session, participants should be able to: Discuss the importance of microbiomes in asthma; Discuss the introduction of new therapies into the present care of 3315 Team Approach to Providing Interdisciplinary asthma; Describe how biologicals can affect asthma care. Care of Atopic Dermatitis 10:45 am to 12:00 pm Marriott North Tower, Lobby Level, New York & Orlando Credit: 1.25 CME / 1.50 CE Moderator: Jennifer S. LeBovidge, PhD Karol G. Timmons, RN MS CPNP Wendy Elverson, RD LDN 11:15 Question & Answer Upon completion of this session, participants should be able to: Describe the formation of a multidisciplinary team to care for children with atopic dermatitis; Discuss the role of a psychologist/mental health professional in an interdisciplinary clinic for children with atopic dermatitis; Describe the role of a nutritionist in an interdisciplinary clinic to optimize nutritional care for patients with atopic dermatitis.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 59 SUNDAY, MARCH 2

Interest Section Forum Interest Section Forum 3522 BCI: Cutting-Edge Research from Members of the 3524 FADDA: Practice Parameter Updates on Allergic Basic and Clinical Immunology Interest Section Skin Diseases 12:30 to 2:30 pm 12:30 to 2:30 pm Convention Center, Upper Level, Room 11AB Convention Center, Upper Level, Ballroom 6A Pre-registration and ticket required. No fee. Box lunch included. Pre-registration and ticket required. No fee. Box lunch included. Bring Credit: 1.25 CME / 1.50 CE your mobile device to participate. Moderator: Francisco A. Bonilla, MD PhD FAAAAI Credit: 1.25 CME / 1.50 CE 12:30 Lunch Moderator: David A. Khan, MD FAAAAI 12:35 Business Meeting 12:30 Lunch Francisco A. Bonilla, MD PhD FAAAAI 12:35 Business Meeting 1:05 Question & Answer David A. Khan, MD FAAAAI 1:15 Nanotechnology Meets Allergy: The Yin and Yang of Nanoscale 1:05 Question & Answer Toxicity and Therapy 1:15 Atopic Dermatitis: Updates on Evaluation and Management from James R. Baker, Jr., MD FAAAAI the Practice Parameter 1:45 Genome Safari: Navigating the Nucleotides to Find the Origins of Lynda C. Schneider, MD FAAAAI Asthma 1:45 Chronic Urticaria: Updates on Diagnostic Testing and Therapy Kathleen C. Barnes, PhD FAAAAI from the Practice Parameter 2:15 Question & Answer Jonathan A. Bernstein, MD FAAAAI Upon completion of this session, participants should be able to: Discuss nanotechnol- 2:15 Question & Answer ogy applications in medicine generally; Identify nanotechnology applications specific to Upon completion of this session, participants should be able to: Describe recent updates allergy and immunology; Describe the most recent advances in genomic approaches to to the practice parameter on atopic dermatitis focusing on evaluation and management of understanding the origins of asthma and allergy. atopic dermatitis; Discuss recent updates to the practice parameter on urticaria focusing on evaluation and management of chronic urticaria. Interest Section Forum Interest Section Forum 3523 EORD: Metals, Cements and Glues: Assessing the Exposure: Diagnosing the Disease 3525 HEDQ: Bringing Added Value to Accountable 12:30 to 2:30 pm Care Organizations (ACOs) Through Asthma Convention Center, Mezzanine Level, Room 14AB Population Management Pre-registration and ticket required. No fee. Box lunch included. 12:30 to 2:30 pm Credit: 1.25 CME / 1.50 CE Convention Center, Mezzanine Level, Room 15AB Moderator: Jeffrey G. Demain, MD FAAAAI Pre-registration and ticket required. No fee. Box lunch included. Bring 12:30 Lunch your mobile device to participate. 12:35 Business Meeting Credit: 1.25 CME / 1.50 CE Karin A. Pacheco, MD MSPH FAAAAI Moderators: Bruce G. Bender, PhD FAAAAI 1:05 Question & Answer Giselle Mosnaim, MD MS FAAAAI 1:15 Metals: Source Exposures, Disease Outcomes, and Making the 12:30 Lunch Association Between the Two 12:35 Tribute to Dr. Noreen Clark James S. Taylor, MD 12:40 Business Meeting 1:45 Cements and Glues: Common and Overlooked Causes of Allergic Giselle Mosnaim, MD MS FAAAAI Disease 1:05 Question & Answer Karin A. Pacheco, MD MSPH FAAAAI 1:15 Asthma Population Management (Part 1): Identifying Persistent 2:15 Question & Answer Asthma, Defining High Risk Asthma, and Measuring Quality of Upon completion of this session, participants should be able to: Recognize common oc- Asthma Care cupational and procedure-related exposures to metals, cements and glues; Identify which Michael Schatz, MD MS FAAAAI of these to suspect in adverse reactions in the workplace or the surgical suite; Describe how best to establish the diagnosis of sensitization to these agents. 1:45 Asthma Population Management (Part 2): Strategies for Improving Clinical Outcomes and Improving Quality of Care William W. Crawford, MD Robert J. Becker, MD, Memorial Lectureship Recipient 2:15 Question & Answer Upon completion of this session, participants should be able to: Define the administra- tive data elements necessary for effective management of large populations of asthma patients; Describe the barriers to reducing emerengy room asthma visits at the level of a large population of asthma patients; Identify strategies for improving performance on publicly reported asthma quality of care measures.

60 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SUNDAY, MARCH 2

Interest Section Forum Allied Health Course 3526 IRSOC: Make Sublingual Immunotherapy One of 3551 The International Network for Diet and Nutrition Your Tools in Your Practice in Allergy (INDANA): Add Nutrition Management 12:30 to 2:30 pm to Your Practice Toolkit Convention Center, Upper Level, Ballroom 6B 12:30 to 5:00 pm Pre-registration and ticket required. No fee. Box lunch included. Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Credit: 1.25 CME / 1.50 CE Pre-registration and ticket required. Fee: $30. Moderator: Désirée E.S. Larenas Linnemann, MD FAAAAI Credit: 4.25 CME / 5.10 CE 12:30 Lunch Moderator: Marion E. Groetch, MS RD 12:35 Business Meeting 12:30 Diet History: Making the Right Connections Désirée E.S. Larenas Linnemann, MD FAAAAI Isabel J. Skypala, PhD 1:05 Question & Answer 1:10 What’s in a Label? 1:15 How to Select and Administer Grass SLIT Among the Patients of Berber Vlieg-Boerstra, PhD RD Your Practice 1:45 Food Triggers: The Degree of Avoidance Michael S. Blaiss, MD FAAAAI Marion E. Groetch, MS RD 1:45 How to Select and Administer House Dust Mite SLIT Among the 2:20 A Day in the Life Patients of Your Practice in the Future Jamie L. Kabourek, MS RD Giovanni Passalacqua, MD 2:55 Break 2:15 Question & Answer 3:10 Oops...Frequently Made Mistakes in Nutrition and Allergy Upon completion of this session, participants should be able to: Comment on which G. Lynn Christie, MS RD patients would make good and which would make bad candidates for SLIT; Discuss safety issues concerning SLIT with grass pollen extracts, especially focused on practical similari- 3:45 Prevention and Weaning ties and differences in Europe and U.S.; Give an overview of innovative formula of house Carina Venter, PhD RD dust mite SLIT, as are the tablets and use of adjuvants and argue how molecular diagnosis 4:20 What is a Healthy Diet Anyway? might have implications for immunotherapy. Kathryn E. Grimshaw, PhD RD Upon completion of this session, participants should be able to: Recognize how to take Interest Section Forum a dietary history and link symptoms to food ingredients; Identify the implications (social, emotional, financial and nutritional) of allergen elimination diets and how to minimize the 3527 MAAI: Novel Mechanisms in Turning impact on patients and families; Describe the nutritional implications of various avoidance In&ammation On and O$ diets and how to advise patients on substitutes to meet nutrient needs. 12:30 to 2:30 pm Convention Center, Mezzanine Level, Room 16AB Oral Abstract Pre-registration and ticket required. No fee. Box lunch included. 3601 Biomarkers Credit: 1.25 CME / 1.50 CE 2:45 to 4:00 pm Moderator: Mitchell H. Grayson, MD FAAAAI Convention Center, Upper Level, Ballroom 6A 12:30 Lunch Credit: 1.25 CME / 1.50 CE 12:35 Tribute to Dr. Redwan Moqbel Moderators: Faoud T. Ishmael, MD PhD FAAAAI 12:50 Business Meeting Leonard B. Bacharier, MD FAAAAI Mitchell H. Grayson, MD FAAAAI 2:45 Socio-Demographic and Environmental Correlates Of Exhaled 1:10 Question & Answer Nitric Oxide Levels 1:15 Epithelial Cell Apoptosis Protects Against Inflammation Lakiea S. Wright, MD MAT Larry Borish, MD FAAAAI 3:00 Relationships Between The New Biomarkers Induced By 1:45 Eicosanoid Storm: The Role of the Inflammasome Interleukin-13 and Bronchial Hyperresponsiveness In Asthmatic Karsten Gronert, PhD Children: Periostin and Squamous Cell Carcinoma-Related 2:15 Question & Answer Antigens Upon completion of this session, participants should be able to: Describe how epithelial Heysung Baek, MD PhD cells control inflammation through ingestion of apoptotic cells; Describe how the inflam- 3:15 Exhaled Nitric Oxide Performance Compared To Methacholine masome contributes to inflammation through the rapid release of eicosanoids. Challenge In Asthma Andrew Nickels, MD 3:30 Serum Interleukin 13 (IL-13) and Surfactant Protein D (SP-D) Expression Is Differentially Associated With Disease Status In Pediatric Asthma Patients Vasiliki Gemou-Engesaeth, MD PhD 3:45 Correlation Of Exhaled Breath Temperature With Age In Chronic Respiratory Diseases Radoslaw Gawlik, MD Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 61 SUNDAY, MARCH 2

Oral Abstract Oral Abstract 3602 Immune Mechanisms in 3604 Drug Allergy 2:45 to 4:00 pm 2:45 to 4:00 pm Convention Center, Upper Level, Room 1AB Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: Antonella Cianferoni, MD PhD Moderators: Mariana C. Castells, MD PhD FAAAAI Hans C. Oettgen, MD PhD FAAAAI Miguel A. Park, MD 2:45 Peripherally Induced Foxp3+ Regulatory T Cells Mediates The 2:45 Safety Of Propofol Use In Patients With Food Allergies Immunomodulatory Effect Of Intravenous Immunoglobulin In An Harshna Mehta, MD Experimental Model Of Allergic Airway Disease 3:00 Risk Stratification Protocol For Carboplatin and Oxaliplatin Amir Hossein Massoud, PhD Hypersensitivity Reactions With Repeat Skin Testing Improves 3:00 Differential DNA Methylation In Mothers Increases The Prevalence Care Of Atopic Dermatitis In Their Offspring Alberta L. Wang, MD Pia J. Hauk, MD 3:15 Added Value Of Skin Testing In Hypersensitivity Reactions To 3:15 Hypereosinophilia In Children and Adults: A Retrospective Taxanes Comparison Matthieu Picard, MD Kelli Williams, MD MPH 3:30 Risk Stratification For Paclitaxel-Induced Hypersensitivity 3:30 Interleukin 35 Modulates TSLP, IL-25 and IL-33 Primed Dendritic Reactions Improves Quality Of Care Cells and Inhibits Naive T Cell Differentiation and Grass Pollen- Timothy P. Lax, MD Specific T Cell Proliferation 3:45 Healthcare Utilization and Serious Infection Prevalence Natalia C. Couto-Francisco Associated With Penicillin “Allergy” In Hospitalized Patients: A 3:45 Fc-Gamma-Receptor-IIb Is Required For The Immunomodulatory Cohort Study Actions Of Intravenous Immune Globulin In An Antigen-Driven Eric M. Macy, MD FAAAAI Murine Model Of Allergic Airways Disease Upon completion of this session, participants should be able to discuss recent research Gabriel N. Kaufman, MSc developments in the field of allergy/immunology. Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. Oral Abstract Oral Abstract 3605 Oral Immunotherapy for Food Allergy 2:45 to 4:00 pm 3603 I. Leonard Bernstein Session on Occupational Convention Center, Upper Level, Ballroom 6B Allergic Diseases Credit: 1.25 CME / 1.50 CE 2:45 to 4:00 pm Moderators: J. Andrew Bird, MD FAAAAI Convention Center, Upper Level, Room 11AB Amy M. Scurlock, MD Credit: 1.25 CME / 1.50 CE 2:45 Length Of Avoidance Period Following Peanut Oral Moderator: Jonathan A. Bernstein, MD FAAAAI Immunotherapy Influences Effector Cell Suppression and Clinical 2:45 Endotoxin In Size-Specific Airborne Particles Induces Differential Outcomes Nitrative Stress In Human Bronchoepithelial Cells Michael D. Kulis Jr., PhD Umesh Singh 3:00 Basophil Hyporesponsiveness To Peanut Following 3:00 High Rates Of Sensitization To Selected Metals and Bone Immunotherapy May Be Transient and Correlates With Clinical Cement In Joint Replacement Failure Patients and Preoperative Response Evaluations Mark Gorelik, MD Karin A. Pacheco, MD MSPH FAAAAI 3:15 Safety Of Pediatric Peanut Oral Immunotherapy Is Complicated By 3:15 Component Resolved Diagnosis In Baker’s Asthma High Adverse Event Rates Cristina Gómez-Casado Yamini Virkud, MD MA 3:30 Endotoxin Exposure May Protect Against The Development Of 3:30 Course and Outcome Of Patients With Asthma During Oral Rhinoconjunctivitis and Respiratory Symptoms In Non-Atopic Immunotherapy To Cow’s Milk Protein Individuals With Occupational Exposure To Mice Arnon Elizur, MD Sharon K. Ahluwalia, MD 3:45 B-Fahf-2 Pretreatment Reduces OIT Adverse Reactions and 3:45 Sensitization To Occupational Allergens and Allergic Diseases In Improves Outcomes In a Murine Model Of Multiple Allergy Workers Of 5 Havana Bakeries Xiu-Min Li, MD Mirta Alvarez, MD Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

62 Allied Health Session ticket required fee required included in the Virtual Annual Meeting SUNDAY, MARCH 2

Oral Abstract Oral Abstract 3606 Adherence 3608 Mechanisms of Eosinophil-Driven Disease 2:45 to 4:00 pm 2:45 to 4:00 pm Convention Center, Upper Level, Room 2 Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: Eugene M. Choo, MD FAAAAI Moderators: Paige Lacy, PhD FAAAAI Sujani Kakumanu, MD Hans-Uwe Simon, MD PhD FAAAAI 2:45 Adherence Documentation During Asthma Encounters At a 2:45 IL-4 and IL-13 Differentially Regulate TLR-Induced Eosinophil- Pediatric Tertiary Care Referral Center Basophil Differentiation Of Cord Blood CD34+ Progenitor Cells Kara J. Wada, MD Pia Reece, PhD 3:00 High-Risk Asthma Multidisciplinary Care Clinic Adherence Linked 3:00 Basophils Act As a Cellular Switch to Drive Eosinophilic To Asthma Control Test (ACT) Score Improvement Inflammation after IgE Activation Bradley A. Locke, DO Laurence E. Cheng, MD PhD 3:15 Understanding Asthma Medical Nonadherence In Adult and 3:15 The SNARE VAMP-7 Contributes To Eosinophil Degranulation, In Pediatric Populations Vivo Joyce Xiang Wu Lee, MD Paige Lacy, PhD FAAAAI 3:30 Improved Education and Self-Management In Children and 3:30 Microbiota Regulates Eosinophils In The Small Intestine Adolescents With Asthma Using a Personalized Smartphone Rodrigo Jimenez-Saiz, PhD Application 3:45 The Airway Mucins Muc5b and Muc4 Are Endogenous Ligands David R. Stukus, MD FAAAAI For Siglec-F and Induce Mouse Eosinophil Death 3:45 Misuse Of Medical Devices Among Patients In a Tertiary Care Takumi Kiwamoto, MD PhD Allergy/Immunology Practice Upon completion of this session, participants should be able to discuss recent research Rana S. Bonds, MD FAAAAI developments in the field of allergy/immunology. Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. Featured Poster Session and Reception 4:00 to 6:00 pm Oral Abstract Convention Center, Upper Level, Ballroom 6 Lobby 3607 Mechanisms of Immunotherapy All Annnual Meeting delegates and their guests are invited to attend 2:45 to 4:00 pm this event. No fee and no pre-registration required. Convention Center, Upper Level, Ballroom 6DE Credit: No CME / No CE Credit: 1.25 CME / 1.50 CE Featured Posters highlight the highest quality abstracts submitted Moderator: Mark Larché, PhD for presentation at the Annual Meeting. During the Featured Poster Session and Reception on Sunday evening, authors will be present 2:45 B Cells and Plasma Cells Populations Suffer Changes Along with their posters to discuss their research. Take this opportunity to The Time After Dermatophagoides Pteronyssinus Specific talk with these authors and network with other meeting delegates. Immunotherapy Enrique Gómez, PhD 3801 Best of ADT 3:00 A Subset Of Novel Timothy Grass Antigens Is Associated With 3802 Advances in Primary Immunode!ciencies Marked Th1/Th2 Shifts Following Specific Immunotherapy 3803 Best of EORD Veronique M. Schulten 3:15 Interleukin IL-27+ Dendritic Cells Modulate Ex-Vivo Th2 3804 Best of FADDA Responses In a Pdl-1-Dependent Manner and Increase In-Vivo 3805 Best of HEDQ Following Grass Pollen Immunotherapy 3806 Chronic Rhinosinusitis and Polyps Tomokazu Matsuoka 3:30 Local ‘Protective’ IgG4 In Nasal Fluid Are Elevated 3807 The Redwan Moqbel Memorial MAAI Featured Following Grass Pollen Immunotherapy Poster Session Jinjin Zhang 3811 Allied Health Featured Poster 3:45 Grass Pollen Immunotherapy: Impaired Allergen-Induced Nasal and Cutaneous Responses Correlate With Overall Seasonal Second Annual ARTrust™ 5K Run/Walk: Light Up Symptom Scores and Are Associated With Suppressed Local Th2 the Night Cytokines In Nasal Fluid Guy W. Scadding, MD 5:30 pm Upon completion of this session, participants should be able to discuss recent research Embarcadero developments in the field of allergy/immunology. This event is open to everyone: serious runners, casual runners, walkers, families and the general public. Registration required. See page 13 for more information. Sponsored by Teva Respiratory.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 63 MONDAY, MARCH 3

Seminars 4007 : New Agents, New 7:00 to 8:00 am Diseases, Prevention and Epidemiology Pre-registration and ticket required. Fee: $40. Continental breakfast Leslie C. Grammer, MD FAAAAI included. Sessions and meals are limited to 30 people. Santiago Quirce, MD PhD Credit: 1.00 CME / 1.20 CE Marriott South Tower, Level 3, Cardiff 4001 Asthma and the Older Adult Upon completion of this session, participants should be able to: Discuss new and updated knowledge in the areas discussed; Describe updated strategies for diagnosis and treat- Alan P. Baptist, MD MPH FAAAAI ment of occupational diseases. Paula L. Busse, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon D 4008 Diagnosing an Allergy to Galactose Alpha 1,3 Upon completion of this session, participants should be able to: Compare how asthma Galactose symptoms and spirometry may differ in older adults compared to younger populations; Scott P. Commins, MD PhD Identify unique factors associated with poor asthma control and quality of life in older Maya R. Jerath, MD PhD adults; Discuss the optimal pharmacologic and non-pharmacologic management strate- gies for older adults with asthma. Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Describe the clinical 4002 Use of Biomarkers in Severe Asthma presentation of alpha gal food allergy; Discuss how to diagnose and manage alpha gal Jonathan Corren, MD food allergy. Faoud T. Ishmael, MD PhD FAAAAI 4009 Non-IgE-Mediated Food Allergies Marriott South Tower, Level 3, Marina Ballroom Salon E Jean-Christoph Caubet, MD Upon completion of this session, participants should be able to: Review and understand Anna H. Nowak-Wegrzyn, MD FAAAAI specific markers (blood and sputum eosinophils, FeNO, periostin, urine leukotrienes, EBT); Describe the relationship of these markers to specific asthma phenotypes and endotypes; Marriott South Tower, Level 3, Miramar Describe the use of these markers as predictors of efficacies of specific therapies. Upon completion of this session, participants should be able to: Discuss a variety of patient cases posing diagnostic dilemmas in non-IgE food allergy; Describe the utility of 4003 Evaluation of Autoin&ammatory Disorders in feeding history, skin prick, serum specific IgE testing and oral food challenge in diagnos- Children ing complex patients with possible GI food allergies. Ronit Herzog, MD FAAAAI 4010 Outcomes and Quality Measures in Allergy Lu Yao, MD Practice and Research Marriott South Tower, Level 3, Marina Ballroom Salon F Chitra Dinakar, MD FAAAAI Upon completion of this session, participants should be able to: Discuss the clinical Kaiser G. Lim, MD FAAAAI and laboratory presentation of children with auto-inflammatory disorder; Describe the pathophysiology of auto-inflammatory disorder in children; Discuss the workup and Marriott South Tower, Level 1, Point Loma management of children with suspected auto-inflammatory disorder. Upon completion of this session, participants should be able to: Describe the most appro- priate outcomes measures for assessment of quality practice in asthma and other allergic 4004 Selection and Implementation of an Electronic diseases; Discuss how to design an outcomes study for asthma. Medical Record 4011 Proactive Management of Food Allergies in David J. Shulan, MD FAAAAI Schools Richard L. Wasserman, MD PhD FAAAAI Alton Lee Melton, MD Marriott South Tower, Level 3, Marina Ballroom Salon G Michael C. Young, MD FAAAAI Upon completion of this session, participants should be able to: Discuss why one would choose an EHR; Describe how to pick an EHR; Identify the needed procedures in imple- Marriott South Tower, Level 1, Solana menting an EHR. Upon completion of this session, participants should be able to: Identify activities and situ- ations in the school setting that place allergic students at risk for accidental food allergen 4005 The Spectrum of Presentations in Patients with exposures; Discuss recommendations for schools and parents regarding best practices Auto-Immune Lymphoproliferative Syndrome for treating reactions that do occur and proactively reducing the risk for accidental food allergen exposures. (ALPS) Jack J.H. Bleesing, MD PhD 4012 New Aspects of the Involvement of B and T Cells in V. Koneti U. Rao, MD the Mechanisms of Immunotherapy Marriott South Tower, Level 3, Balboa Mubeccel Akdis, MD PhD Upon completion of this session, participants should be able to: Discuss common findings Mark Larche, PhD in patients with ALPS; Review current laboratory testing for the disease; Discuss treat- Marriott South Tower, Level 1, Santa Rosa ment options for ALPS. Upon completion of this session, participants should be able to: Review new data of 4006 How to Get Your K Award Applications by a Mock regulatory T cell involvement in the immunologic reactions documented after immuno- therapy; Review new data of regulatory B cell involvement in the immunologic reactions Study Section documented after immunotherapy; Discuss the interactions between both these systems. Nora A. Barrett, MD FAAAAI Lawrence J. Prograis, MD Joshua A. Boyce, MD FAAAAI Marriott South Tower, Level 3, Mission Hills Annual Meeting Seminars Upon completion of this session, participants should be able to: Describe the peer review process for K award applications; Describe common strengths and weaknesses in K Programmed by the AAAAI. Annual Meeting Seminars funded award applications as identified by reviewers; Apply knowledge of common review through an educational grant from Merck. concerns to the preparation of a competitive K award application.

64 Allied Health Session ticket required fee required included in the Virtual Annual Meeting MONDAY, MARCH 3

4013 Chronic Rhinosinusitis Subtypes and Treatment Plenary Implications 4101 Drug Allergy in the 21 st Century Amber U. Luong, MD PhD 8:15 to 9:45 am Rodney J. Schlosser, MD Convention Center, Ground Level, Exhibit Hall A Marriott South Tower, Level 4, La Costa Credit: 1.50 CME / 1.80 CE Upon completion of this session, participants should be able to: Describe the classification Moderator: David A. Khan, MD FAAAAI of sinusitis; Describe the clinical subtypes of chronic rhinosinusitis; Explain the different non-surgical treatment options for the different chronic rhinosinusitis subtypes. 8:15 HLA and Drug Hypersensitivity David A. Ostrov, PhD 4014 How Do Antigens Become Allergens? 8:45 Exanthematous Drug Eruptions Angela Haczku, MD PhD FAAAAI Werner J. Pichler, MD Anne Sperling, PhD Marriott South Tower, Level 4, Catalina 9:15 New Challenges and Outcomes for Drug Desensitization Upon completion of this session, participants should be able to: Describe how the immune Mariana C. Castells, MD PhD FAAAAI system recognizes innocuous allergens; Discuss dendritic cells, important sentinel cells in Upon completion of this session, participants should be able to: Discuss the genetic allergy; Identify the development of therapeutic agents that could fine tune the dendritic basis for selected drug reactions; Recognize and interpret erythematous drug eruptions; cell response. Develop expertise in the management of hypersensitivity reactions to chemotherapy, monoclonals, new biologicals and antibiotics. 4015 Th17 Cells, Neutrophils and Severe Asthma Dawn C. Newcomb Baker, PhD Posters R. Stokes Peebles, Jr., MD FAAAAI 7:00 am to 6:00 pm Marriott South Tower, Level 4, Coronado Convention Center, Ground Level, Exhibit Hall B Upon completion of this session, participants should be able to: Describe the role of STAT Posters on display from 7:00 am to 6:00 pm. Authors present from signaling in Th17 cell development and cytokine expression; Define the role of gender in Th17 cell differentiation and cytokine expression in patients with severe asthma; Discuss 9:45 to 10:45 am. the role of IL-17A on structural cells in the airway. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors. Allied Health Course 4201 Epidemiology: Asthma Control 4051 Primer on Primary Immune De!ciency (PIDD) 4202 Biomarkers and Asthma Control II 8:00 am to 2:15 pm 4203 IVIG and Other Therapeutics Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Pre-registration and ticket required. Fee: $85. Box lunch included. 4204 Autoin&ammatory Disorders Credit: 5.50 CME / 6.60 CE 4205 Airborne Allergen Exposures Moderator: Debra A. Sedlak, MSN CPNP 4206 Infections, Asthma and Allergies 8:00 Overview of PIDD: Disease Characteristics and Presentation M. Elizabeth M. Younger, CRNP PhD 4207 Immune Mediated Skin Diseases 8:45 Basics of Diagnostic Testing 4208 Food Allergy II William R. Blouin, ARNP 4209 Health Care Delivery 9:30 Non-Immune Replacement Therapies Kristin Epland, NP 4210 Allergen Extracts and Immunotherapy 10:15 Break 4211 Outcome Measures and Challenge Testing with 10:30 Immune Replacement: Is There a Right Way? Immunotherapy Debra A. Sedlak, MSN CPNP 4212 Mechanistic Insight into Pollens and Other 11:15 Transplantation in PIDD Antigens M. Louise Markert, MD PhD FAAAAI 12:00 Lunch Break 12:30 Panel Discussion Moderator: M. Elizabeth M. Younger, CRNP PhD Panelists: M. Elizabeth M. Younger, CRNP PhD William R. Blouin, ARNP Kristin Epland, NP Debra A. Sedlak, MSN CPNP M. Louise Markert, MD PhD FAAAAI 1:30 Hands-On Instruction: SCIG Carla M. Duff, CPNP MSN Kristin Epland, NP Upon completion of this session, participants should be able to: Identify and develop understanding of the multiple presentations of PIDD; Describe the various laboratory tests and appropriate application of these tests in the evaluation for PIDD; Develop an under- standing of the treatments utilized in the management and treatment of PIDD.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 65 MONDAY, MARCH 3

Symposium Symposium 4301 American Lung Association Clinical Trials 4304 How Close are We to Preventing Asthma by Network: Recent Advances Vaccination? 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6B Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Stephen P. Peters, MD PhD FAAAAI Moderator: R. Stokes Peebles, Jr., MD FAAAAI 10:45 Validation Studies of Asthma Outcomes for Clinical Research 10:45 The Role of Rhinovirus and RSV in Asthma Incepton Speaker to be announced. Tina V. Hartert, MD MPH 11:05 Pharmacogenomic Studies of Asthma from the ALA ACRC 11:05 The Current State of Rhinovirus Vaccine Development Network Sebastian L. Johnston, MD PhD John Lima, MD 11:25 The Current State of RSV Vaccine Development 11:25 SOYA: Effect of Soy Isoflavones on Asthma S. Graham, MD PhD Lewis J. Smith, MD 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: Define the data that link Upon completion of this session, participants should be able to: List newly defined asthma severe lower infection with rhinovirus and respiratory syncytial virus in outcome measures; Describe the effect of new therapeutic options in asthma; Discuss infancy and the subsequent development of childhood asthma; Describe the current state new information on pharmacogenomics in asthma. of vaccine development for respiratory syncytial virus; Describe the current state of vac- cine development for rhinovirus. Symposium Symposium 4302 Primary Immunode!ciency at the Molecular 4305 B Cell and Antibody Biology in Upper and Lower Level: The Wave of the Future 10:45 am to 12:00 pm Airways Convention Center, Upper Level, Ballroom 6CF 10:45 am to 12:00 pm Credit: 1.25 CME / 1.50 CE Convention Center, Mezzanine Level, Room 14AB Moderator: Elena E. Perez, MD PhD FAAAAI Credit: 1.25 CME / 1.50 CE Moderator: Patricia A. Takach, MD FAAAAI 10:45 Update on Newborn Screening for PID Jennifer M. Puck, MD 10:45 Epidemiology and Burden of Antibody Deficiency in Chronic Rhinosinusitis 11:05 New Immunodeficiencies Defined by Genomic Methods Anju T. Peters, MD FAAAAI Janet S. Chou, MD 11:05 B Cell Responses in Chronic Rhinosinusitis 11:25 Gene Therapy for PID: Quo Vadis? Kathryn E. Hulse, PhD Fabio Candotti, MD 11:25 Regulation of B Cell Activation and Antibody Production 11:45 Question & Answer Mubeccel Akdis, MD PhD Upon completion of this session, participants should be able to: Discuss what progress has been made in the diagnosis of immunodeficiency at birth via newborn screening; 11:45 Question & Answer Describe how genomic analysis is leading to an explosion in the discovery of new forms Upon completion of this session, participants should be able to: Describe the epidemiol- of immunodeficiency; Identify what advances are being made in gene therapy for im- ogy of antibody deficiency in chronic rhinosinusitis; Discuss the role of B cells in chronic munodeficiency. rhinosinusitis; Identify the role of IgA in mucosal immunity in allergic diseases. Symposium Symposium 4303 Treatment Alternatives for Refractory Severe 4306 Immunosenescence: Implications of an Aging Asthma Immune System 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6DE Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Paula L. Busse, MD FAAAAI Moderator: Sharmilee M. Nyenhuis, MD FAAAAI 10:45 The Role of Anti-Cholinergics, Vitamin D Replacement and Fine 10:45 Effects of Aging on Immune Function Particle ICS Jorg Goronzy, MD PhD Reynold A. Panettieri, MD 11:05 Vaccine Responses in the Elderly 11:05 The Role of Bronchial Thermoplasty John M. Kelso, MD FAAAAI Monica Kraft, MD 11:25 Effect of Aging on Asthma and Allergic Diseases 11:25 Novel Approaches to Steroid Resistance Sameer K. Mathur, MD PhD FAAAAI Stanley J. Szefler, MD FAAAAI 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: Describe changes in im- Upon completion of this session, participants should be able to: Describe the risks and mune function with aging; Describe changes in vaccine response and current recommen- benefits of bronchial thermoplasty in severe asthma; Outline novel approaches to therapy dations for vaccination in the elderly; Discuss the effect of aging on allergic diseases. of steroid resistant asthma; Discuss the evidence supporting the use of vitamin D replace- ment, anti-cholinergics and small particle inhaled corticosteroids.

66 Allied Health Session ticket required fee required included in the Virtual Annual Meeting MONDAY, MARCH 3

Symposium Oral Abstract 4307 Wanted: Eosinophils, Dead or Alive? Eosinophil 4602 Bone Marrow Transplantation in Primary Cell Death Subroutines and Implications for Immunode!ciencies Eosinophil-Targeted Therapy 2:00 to 3:15 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Room 11AB Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator to be announced. Moderator: Gerald J. Gleich, MD FAAAAI 2:00 G Protein-Coupled Receptor Kinase-3 (GRK-3) In Bone Marrow 10:45 Eosinophil Extracellular DNA Trap Cell Death (ETosis) Mediates Niche Interactions and Transplantation Lytic Release of Free Secretion-Competent Eosinophil Granules Jaime M. Brozowski Lisa A. Spencer, PhD FAAAAI 2:15 Allogeneic Hematopoietic Stem Cell Transplantation For Immune 11:05 Siglec-8 Engagement Induces Apoptotic or Lytic Eosinophil Cell Dysregulation, Polyendocrinopathy, X-Linked (IPEX) Syndrome Death, Depending on Cell Activation Status Resolves Enteropathy and Autoimmunity: A Single Institution Nives Zimmermann, MD FAAAAI Experience 11:25 Targeting Eosinophils in Disease Zeynep Yesim Yesim Kucuk, MD Parameswaran K. Nair, MD PhD FRCP 2:30 Natural Killer Cell Immunoglobulin Like Receptor (KIR) Genetic 11:45 Question & Answer Profile Is a Strong Predictor Of Allogeneic Hematopoietic Cell Upon completion of this session, participants should be able to: Identify cell death Transplant Outcomes subroutines; Discuss consequences of eosinophils’ dying by different subroutines; Discuss Rehan M. Faridi, PhD consequences of cell death subroutines on efficacy and safety of eosinophil-targeting 2:45 Transient Lymphopenia Of Infancy: A Previously Unrecognized agents. Entity Robert Sporter, MD AAAAI Business Meeting Upon completion of this session, participants should be able to discuss recent research 12:30 to 1:30 pm developments in the field of allergy/immunology. Convention Center, Upper Level, Ballroom 6A All AAAAI Fellows and members should attend this annual business Oral Abstract meeting. Box lunches included. No fee. No pre-registration required. 4603 Air Pollution/Allergens/Air Quality 2:00 to 3:15 pm Oral Abstract Convention Center, Upper Level, Room 5AB 4601 Adherence Credit: 1.25 CME / 1.50 CE Moderator: Neil Alexis, PhD 2:00 to 3:15 pm 2:00 Associations Among Volatile Organic Compounds, Allergic Convention Center, Upper Level, Ballroom 6B Sensitization, and Respiratory Illness In Children With Asthma Credit: 1.25 CME / 1.50 CE Enrolled In a Study Of Low-Income, Green Eco-Friendly Housing Moderator: Mark F. Sands, MD FAAAAI (The Green Housing Study) 2:00 Poor Asthma Control In Older Adults Is Associated With Reduced Joy Hsu, MD MSCI Adherence To Controller Therapies and Inability To Afford 2:15 A Systematic Analysis Of Pollen Transcriptomes From Plant Medications Allergens Reveals Conserved Targets Of Immune Responses Jessica Tan, MD MPH Bjoern Peters 2:15 Texting Medication Reminders For Better Asthma Control In 2:30 Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Th2 Children and Teens Immunity In Children Humaa M. Bhatta, DO Kinjal M. Hew, PhD 2:30 Adherence To Prescribed Controller Therapy and Effects On 2:45 Impact Of BMI On Ozone-Induced IL-1 In The Airways Of Human Asthma Control In The Hispanic Population Of a Pediatric Disease Volunteers Management Program Michelle L. Hernandez, MD Lyne G. Scott, MD 3:00 Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced 2:45 Correlation Between Emergency Department Visits For Asthma Airway Inflammation and Hyperresponsiveness (AHR) Exacerbation and No Show Visits To Primary Care Provider In a Qi Yang, PhD Pediatric Population Upon completion of this session, participants should be able to discuss recent research Margaret Redmond, MD developments in the field of allergy/immunology. 3:00 Choosing Wisely: Adherence By Allergists To Recommended Use Of Spirometry In The Diagnosis and Management Of Adult Asthma Kristin C. Sokol, MD MPH Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 67 MONDAY, MARCH 3

Oral Abstract Oral Abstract 4604 Food Allergy 4606 Chronic Rhinosinusitis 2:00 to 3:15 pm 2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6CF Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Rima A. Rachid, MD FAAAAI Moderator: Anju T. Peters, MD FAAAAI 2:00 Peanut T Cell Epitope Discovery: Ara h1 and Ara h3 2:00 The Clinical Significance Of Specific Antibody Deficiency (SAD) Manish Ramesh, MD PhD Severity In Chronic Rhinosinusitis (CRS) 2:15 Microparticles Encapsulated With Antigen Protect Against Anjeni Keswani, MD Sensitization and Reduce Anaphylactic Reactivity In a Food 2:15 Meta-Analysis Of Gene Expression Microarrays Reveals Novel Allergy Model Biomarkers Consistent With Altered Functionality Of Mucosal Karen B. Chien, PhD Barrier In Patients With Chronic Rhinosinusitis 2:30 Over-The-Counter Dietary Supplements Genistein and Ipriflavone Sergejs Berdnikovs, PhD Suppress Peanut Allergy Symptoms 2:30 Evidence For Immunoglobulin D In Patients With Chronic Lisa Chang, BS Rhinosinusitis 2:45 Analyzing Casein-Specific IL-4 and IL-13 Secreting T-Cells: A Jin Young Min, MD PhD Reliable Tool For Diagnosis Of Cow’s Milk Allergy 2:45 Oncostatin M Is Elevated In Chronic Rhinosinusitis and Decreases Benedicte Michaud, MD PhD Barrier Function In Human Airway Epithelium 3:00 Growth Of Children Aged 2-17 With Cow’s Milk, Peanut, and Egg Kathryn L. Pothoven Allergy In NHANES 3:00 Immunologic Changes During Chronic Rhinosinusitis Karin Robbins, MD Exacerbations Compared To Controls Upon completion of this session, participants should be able to discuss recent research Shefali Samant, MD developments in the field of allergy/immunology. Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. Oral Abstract Oral Abstract 4605 Epidemiology 2:00 to 3:15 pm 4607 Mechanisms of Asthma and Allergic Disease Convention Center, Upper Level, Room 7AB 2:00 to 3:15 pm Credit: 1.25 CME / 1.50 CE Convention Center, Upper Level, Room 1AB Moderator: Chitra Dinakar, MD FAAAAI Credit: 1.25 CME / 1.50 CE 2:00 Allergic Causes Of Death In The United States Moderator: Nora A. Barrett, MD FAAAAI Susan J. Kim, MD 2:00 Allergen Challenge Increases Peripheral Blood CD84+ ILC2 In 2:15 Death From Anaphylaxis Is a Reassuringly Unusual Outcome Allergic Rhinitis Larry Borish, MD FAAAAI David R. Scott, MD 2:30 Allergic Rhinitis, Asthma and Cardiovascular Disease 2:15 Asthma Susceptibility Due To Environmental Programming Of Angela M. Crans Yoon, MD Innate Immunity In Utero 2:45 Pre-Natal and Early Life Predictors Of Atopy In Canadian Children: Sarah Manners, BS Results Of The Family Study 2:30 Rhinovirus Challenge Augments Allergen Responsiveness In Tahira Batool, MBBS Basophils Of Atopic Asthmatics 3:00 Association Between Antibiotic Treatment In The First Six Months Rachana Agrawal, PhD Of Life and Clinical Allergic Outcomes At Ages 2 To 3 Years 2:45 Der p 3 Allergen Activated Ano-1 Channel On Afferent Airway Kyra Jones, MEd Nerves Regulates Th2 Cell Responses Upon completion of this session, participants should be able to discuss recent research Mayur Patil, MS developments in the field of allergy/immunology. 3:00 Increased Serum Soluble ST2 In Asthmatic Children and Recurrent Early Wheezers Hai Lee Chung, MD PhD Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

68 Allied Health Session ticket required fee required included in the Virtual Annual Meeting MONDAY, MARCH 3

Late Breaking Oral Abstract Session Q & A Workshop 4611 Basic Translational Sciences 4802 Social Media: The Future is Here 2:00 to 3:15 pm 4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 15AB Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderators: Francisco A. Bonilla, MD FAAAAI Moderator: Melinda M. Rathkopf, MD FAAAAI Mitchell H. Grayson, MD FAAAAI 4:45 Using Twitter 2:00 Human TNFR2 Exhibits Bi-Directional Control over Regulatory Nathaniel D. Hare, MD FAAAAI T Cells 5:00 Using Facebook Denise L. Faustman, MD Gerald B. Lee, MD 2:15 Contribution of Sequential and Conformational IgE-Binding 5:15 Creating a Blog/Website Epitopes to the Allergenicity of Major Peanut Allergen Ara h 2 Ves Dimov, MD Stephane Hazebrouck, PhD 5:30 Question & Answer 2:30 Immunocap Cellulose Displays Cross-Reactive Carbohydrate Upon completion of this session, participants should be able to: Discuss how the utilization Epitopes and Can Cause False-Positive Test Results in Patients of social media in allergy and immunology practices can lead to improved patient educa- with Anti-CCD IgE Antibodies tion and satisfaction; Identify a step-wise plan for the implementation and maintenance Wolfgang Hemmer, PhD of a social media strategy; Identify and implement processes designed to protect PHI and prevent HIPAA violations when using healthcare social media. 2:45 The RNA-Binding Protein Hur Is Required to Control Cytokine Expression in CD4+ T Cells Problem-Based Learning Workshop Ulus Atasoy, MD FAAAAI 3:00 Whole-Exome Sequencing Reveals IKBKB As a Cause of 4803 Making the Practice Parameters Work for You: Combined Immunodeficiency Using a Quality Improvement Approach Talal Mousallem, MD 4:45 to 6:00 pm Upon completion of this session, participants should be able to discuss recent research Convention Center, Upper Level, Room 3 developments in the field of allergy/immunology. Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE Cutting-Edge Research Keynote PBL Facilitator: Jay M. Portney, MD FAAAAI 4701 Nanotechnology Applications in Content Lecturer: Marcus S. Shaker, MD MS FAAAAI Upon completion of this session, participants should be able to: Describe how quality im- Immunology and Allergy provement initiatives can be used to implement practice parameters in the clinical setting; 3:30 to 4:30 pm Define fundamentals of quality improvement; Define how quality improvement initiatives Convention Center, Ground Level, Exhibit Hall A can be applied in maintenance of certification requirements. Credit: 1.00 CME / 1.20 CE Moderator: Paul V. Williams, MD FAAAAI Panel Discussion Workshop James R. Baker, Jr., MD FAAAAI Ruth Dow Doan Professor, Director, Michigan Nanotechnology Institute 4804 Use of Gamma Globulin in Clinical Practice: for Medicine and Biological Sciences Indications, Challenges, Adverse Reactions and Upon completion of this session, participants should be able to describe how nanotechnol- Monitoring ogy can be utilized in drug delivery and disease management. 4:45 to 6:00 pm Convention Center, Upper Level, Room 5AB Panel Discussion Workshop Credit: 1.25 CME / 1.50 CE Moderator: Elena E. Perez, MD PhD FAAAAI 4801 Mast Cell Activation Disorders: A Plan of Attack Panelists: 4:45 to 6:00 pm Mark Ballow, MD FAAAAI Convention Center, Upper Level, Room 1AB Vivian P. Hernandez-Trujillo, MD FAAAAI Credit: 1.25 CME / 1.50 CE Rima A. Rachid, MD FAAAAI Moderator: Melody C. Carter, MD Upon completion of this session, participants should be able to: Discuss the relative Panelists: virtues of intravenous and subcutaneous IgG therapy; Review common approaches to Cem Akin, MD PhD FAAAAI reducing the systemic side effects of IGIV and managing adverse reactions; Discuss how Lawrence B. Schwartz, MD PhD FAAAAI to optimize IgG replacement therapy in immunodeficiency patients to minimize infections Catherine R. Weiler, MD PhD FAAAAI and maintain appropriate levels of Ig with maximal benefit. Upon completion of this session, participants should be able to: Differentiate between mast cell activation disorder, monoclonal mast cell activation syndrome and mastocytosis; Determine which objective data is useful in defining the diagnosis of each entity. Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 69 MONDAY, MARCH 3

Q & A Workshop Q & A Workshop 4805 In&uenza and Pneumococcal Vaccines in 4808 FDA: Update from the U.S. Food and Drug Asthmatic Patients Administration 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6B Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Pedro C. Avila, MD FAAAAI Moderator: F. Estelle R. Simons, MD FAAAAI 4:45 Burden of Influenza and Invasive Pneumococcal Disease in 4:45 Year-in-Review: An Update from the U.S. Food and Drug Asthmatic Patients Administration Tina V. Hartert, MD MPH Badrul A. Chowdhury, MD PhD FAAAAI 5:00 Influenza and Pneumococcal Vaccines in Asthmatic Patients: 5:00 Over-the-Counter (OTC) Marketing of Allergy Drug Products Benefits and Risks Sofia A. Chaudhry, MD John M. Kelso, MD FAAAAI 5:15 Eosinophilic Asthma: Considerations for Drug Product 5:15 New Influenza Vaccines for the 21 st Century Development Speaker to be announced. Susan Lee Limb, MD FAAAAI 5:30 Question & Answer 5:30 Question & Answer Upon completion of this session, participants should be able to: Discuss the burden of Upon completion of this session, participants should be able to: Review recent issues of influenza and invasive pneumococcal disease in asthmatic patients; Describe the types, scientific importance at FDA and their regulatory implications; Identify issues related to benefits and risks of influenza and pneumococcal vaccines for asthmatic patients. the over-the-counter (OTC) marketing of allergy drug products; Recognize issues in the clinical development of drug products for eosinophilic asthma. Year-in-Review Workshop Q & A Workshop 4806 Practical Aspects of SCID Newborn Screening 4:45 to 6:00 pm 4809 Innate Immunity Modulators in the Lung Convention Center, Upper Level, Ballroom 6CF 4:45 to 6:00 pm Credit: 1.25 CME / 1.50 CE Convention Center, Upper Level, Room 7AB Moderator: Kathleen E. Sullivan, MD PhD FAAAAI Credit: 1.25 CME / 1.50 CE 4:45 Secondary Evaluation of SCID Screen-Positive Infants Moderator: Harald E. Renz, MD Jolan E. Walter, MD PhD 4:45 Anionic Pulmonary Surfactant Phospholipids Act as a Regulator 5:00 PID Diagnosed Using TRECs for Newborn Screening of Inflammation and Viral Infection in the Lung John M. Routes, MD FAAAAI Dennis R. Voelker, PhD 5:15 PID Cases Missed Using TRECs for Newborn Screening 5:00 Surfactant Protein-A and D in Airway Inflamation Jennifer M. Puck, MD Angela Haczku, MD PhD FAAAAI 5:30 Question & Answer 5:15 Antagonism of Toll-Like Receptor Activation in Lung Disease Upon completion of this session, participants should be able to: Review secondary Anthony A. Horner, MD FAAAAI evaluation of SCID screen positive infants; Identify the cases that are detected via TRECs 5:30 Question & Answer screening; Identify PID that can be potentially missed via TRECs screening. Upon completion of this session, participants should be able to: Recognize the capacity of surfactant phospholipids in suppression of lung inflammation due to aeroallergen, Q & A Workshop bacterial infection and viral infection; Describe how surfactant protein-A suppresses lung inflammation and damage due to bacterial infection; Discuss the specificity and 4807 Standardization of Oral Food Challenges: How mechanisms of immune regulation regulated by pulmonary surfactant phospholipids and Golden is the Gold Standard? Protein-A. 4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Annual Meeting Workshops Moderator: Scott H. Sicherer, MD FAAAAI Programmed by the AAAAI. Annual Meeting Workshops funded 4:45 The Food Challenge PRACTALL Guidelines: What are They and through an educational grant from Merck. When Should they be Used? Hugh A. Sampson, MD FAAAAI 5:00 Why do We Need to Standardize OFC Stopping Criteria: What are the Controversies? David Mark Fleischer, MD FAAAAI 5:15 What is the Role of OFC in Oral Immunotherapy Trials? Kirsten Beyer, MD 5:30 Question & Answer Upon completion of this session, participants should be able to: Discuss the different methodologies for oral food challenges; Describe the controversies around objective stop- ping criteria and the evidence base for this; Describe how and when to use different types of challenge methodologies.

70 Allied Health Session ticket required fee required included in the Virtual Annual Meeting MONDAY, MARCH 3

Q & A Workshop Q & A Workshop 4810 Allergic In&ammation: New Advances in 4813 Stepping Down Asthma Medications: Bene!ts Chemokines and Cell Signaling and Risks 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Room 11AB Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: David H. Broide, MB ChB FAAAAI Moderator: Chitra Dinakar, MD FAAAAI 4:45 The Role of CCL18 in Chronic Allergic Inflammation 4:45 Which Patients May Be Good Candidates for Stepping Down Andrew D. Luster, MD PhD Asthma Medications? 5:00 Eosinophilic Esophagitis: The Role of Eotaxins and Other Fernando D. Martinez, MD Chemokines 5:00 Understanding the Risks and Benefits of Stepping Down Asthma Amal H. Assa’ad, MD FAAAAI Medication 5:15 Mast Cells in Chronic Allergic Inflammation John B. Hagan, MD FAAAAI Stephen J. Galli, MD 5:15 Comparing Asthma Step-Down Strategies: Is “Dynamic Dosing” 5:30 Question & Answer Ready for Prime Time? Upon completion of this session, participants should be able to: Discuss how chemokines Paul M. O’Byrne, MD FAAAAI such as CCL18 are important in allergic inflammation, particularly in atopic dermatitis; 5:30 Question & Answer Identify how cytokines such as eotaxins play an important role in eosinophilic esophagitis; Upon completion of this session, participants should be able to: Identify asthma patients Describe the role of mast cells in chronic allergic inflammation and how innate mediators who may be good candidates for stepping down their asthma medication; Describe the and Th2 inflammation exacerbate allergic disease. risks associated with stepping down asthma medication with the best currently available evidence; Compare and contrast different types of step down strategies. Panel Discussion Workshop 4811 Dilemmas in the Management of Allergic Q & A Workshop Bronchopulmonary Mycosis 4814 Chronic Rhinosinusitis in Children 4:45 to 6:00 pm 4:45 to 6:00 pm Convention Center, Upper Level, Room 8 Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Andrew J. Wardlaw, MD PhD Moderator: Martin Wagenmann, MD FAAAAI Panelists: 4:45 Pathophysiology of Chronic Rhinosinusitis in Children Leslie C. Grammer, MD FAAAAI Daniel L. Hamilos, MD Catherine A. Pashley, PhD 5:00 Medical Workup and Treatment of Chronic Rhinosinusitis in Raymond G. Slavin, MD MS FAAAAI Children Upon completion of this session, participants should be able to: Describe which fungi can David W. Hauswirth, MD FAAAAI cause ABPM and how they might cause lung damage; Review the clinical spectrum of 5:15 Surgical Treatment of Chronic Rhinosinusitis in Children how ABPM presents; Discuss how to optimally manage ABPM. Fuad M. Baroody, MD FAAAAI Q & A Workshop 5:30 Question & Answer Upon completion of this session, participants should be able to: Discuss the pathophysi- 4812 Utility of FeNO in the Diagnosis and Management ology of CRS in children; List the workup and medical treatment of children with CRS; of Asthma: Comparison to Other Measures Review the surgical approach to CRS in children after failure of medical therapy. 4:45 to 6:00 pm

Convention Center, Mezzanine Level, Room 14AB Problem-Based Learning Workshop Credit: 1.25 CME / 1.50 CE 4815 Aspirin Desensitization for Aspirin-Exacerbated Moderator: Harold S. Nelson, MD FAAAAI Respiratory Disease: Indications, Protocols and 4:45 The Use of FeNO in Adult Asthma Pitfalls Miguel J. Lanz, MD FAAAAI 4:45 to 6:00 pm 5:00 The Use of FeNO in Pediatric Asthma Convention Center, Upper Level, Room 31C Stanley J. Szefler, MD FAAAAI Pre-registration and ticket required. Fee: $50. 5:15 Practical Implications of Implementing FeNO in Clinical Practice Credit: 1.25 CME / 1.50 CE Joseph D. Spahn, MD PBL Facilitator: Richard W. Weber, MD FAAAAI 5:30 Question & Answer Content Lecturer: Donald D. Stevenson, MD FAAAAI Upon completion of this session, participants should be able to: Describe the appropriate Upon completion of this session, participants should be able to: Describe indications for uses of FeNO in adults; Review the appropriate uses of FeNO in children; Discuss the aspirin desensitization for aspirin exacerbated respiratory disease; Identify problems that practical implications of implementing FeNO in clinical practice. can occur with aspirin desensitization and develop strategies for how to deal with these problems.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 71 MONDAY, MARCH 3

Seminars 4826 Exercise-Induced Anaphylaxis and Food- 4:45 to 5:45 pm Dependent Exercise-Induced Anaphylaxis Pre-registration and ticket required. Fee: $40. Refreshments included. Anna M. Feldweg, MD Sessions and refreshments are limited to 30 people. Kirsi M. Jarvinen-Seppo, MD PhD Credit: 1.00 CME / 1.20 CE Marriott South Tower, Level 1, Point Loma 4821 From Urticaria to Toxic Epidermal Necrolysis: Upon completion of this session, participants should be able to: Review the most common clinical presentations of EIAn and typical foods that can trigger FD-EIAn; Identify recent Cutaneous Drug Eruptions for the Clinician publications relevant to EIAn and FD-EIAn; Increase understanding of treatment options for Jennifer S. Kim, MD FAAAAI EIAn and FD-EIAn. Peter A. Lio, MD Marriott South Tower, Level 3, Marina Ballroom Salon G 4827 Physical Urticarias Mario Geller, MD FAAAAI Upon completion of this session, participants should be able to: Evaluate cutaneous drug eruptions and render a diagnosis with confidence; Analyze evidence-based medicine to Karen S. Hsu Blatman, MD current therapeutic options for these conditions. Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Identify physical urticarias; 4822 Smoking and Asthma: Not Just Blowing Smoke Evaluate and educate patients with physical uticarias; Manage and treat physical urticarias Riccardo Polosa, MD PhD FAAAAI with the recent data. Mark F. Sands, MD FAAAAI Marriott South Tower, Level 3, Balboa 4828 Advanced Coding for the Allergist Noga Askenazi, MD FAAAAI Upon completion of this session, participants should be able to: Describe the pathophysio- logic consequences of tobacco smoking upon the asthmatic; Discuss the effect of tobacco Gary N. Gross, MD FAAAAI smoke on the lung from fetus through adult life; Describe effective smoking cessation Marriott South Tower, Level 1, Santa Rosa interventions. Upon completion of this session, participants should be able to: Discuss the use of codes pertinent to allergy/immunology practice; Describe details of coding for patients’ allergy 4823 Gene Therapy for Primary Immunode!ciency testing and immunotherapy. Disorders: Where are We in 2014? 4829 Immunode!ciencies Discovered in the Last Five Fabio Candotti, MD Matthew Porteus, MD PhD Years Marriott South Tower, Level 3, Mission Hills Francisco J. Espinosa-Rosales, MD Upon completion of this session, participants should be able to: Review the primary Gulbu Uzel, MD immunodeficiency disorders for which gene therapy is a treatment option; Discuss the Marriott South Tower, Level 4, La Costa mechanism of gene therapy; Discuss limitations and risks associated with gene therapy. Upon completion of this session, participants should be able to: Discuss the new primary immunodeficiency diseases with a focus on those described during the past five years; 4824 Occupational Respiratory Diseases Describe the newer technologies used for discovery of these and future disorders; Identify André Cartier, MD FAAAAI the expanding overlap between immunodeficiency and inflammatory disorders. Susan M. Tarlo, MBBS FAAAAI Marriott South Tower, Level 3, Cardiff 4830 Management of Children and Adult Patients with Upon completion of this session, participants should be able to: Recognize the history Atopic Dermatitis clues pointing to potential work-related asthma; Develop familiarity with the approach Jon M. Hanifin, MD FAAAAI needed to establish the diagnosis of occupational asthma; Compare the strengths and Dagmar Simon, MD weaknesses of the tools available to establish work-relatedness. Marriott South Tower, Level 4, Catalina 4825 Asthma Management Among Minority Upon completion of this session, participants should be able to: Describe the presenta- tion, pathophysiology and complications of atopic dermatitis; Discuss the management of Populations: Practical Insights for Clinicians, these patients, including their education; Discuss possible therapeutic consequences due Researchers and Public Health Planners to new insights into the pathogenesis of atopic dermatitis. Alan P. Baptist, MD MPH FAAAAI Christine L.M. Joseph, PhD Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Identify the healthcare disparities that exist in asthma care; Discuss reasons why these disparities exist; Discuss effective strategies to treat minority populations, thereby decreasing health disparities in asthma.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

72 Allied Health Session ticket required fee required included in the Virtual Annual Meeting TUESDAY, MARCH 4

Seminars 5008 Challenges of Managing Multiple Food Allergies 7:00 to 8:00 am Julie Wang, MD FAAAAI Pre-registration and ticket required. Fee: $40. Continental breakfast Michael C. Young, MD FAAAAI included. Sessions and meals are limited to 30 people. Marriott South Tower, Level 4, Catalina Credit: 1.00 CME / 1.20 CE Upon completion of this session, participants should be able to: Identify the diagnostic and management challenges of multiple food allergies; Recognize the nutritional, feeding and 5001 Resistance in Asthma social risk factors; Develop and implement a feeding plan for adequate nutrition, feeding Elena Goleva, PhD skill and social development of children with multiple food allergies. Faoud T. Ishmael, MD PhD FAAAAI 5009 SLIT vs. SCIT in Children Marriott South Tower, Level 3, Balboa Giovanni Passalacqua, MD Upon completion of this session, participants should be able to: Discuss current ap- proaches for clinical evaluation of potential insensitivity to oral and inhaled CS; Describe David P. Skoner, MD glucocorticoid receptor function and current understanding of the molecular pathways Marriott South Tower, Level 4, Coronado that lead to CS insensitivity; Explain the interaction of the glucocorticoid receptor with Upon completion of this session, participants should be able to: Summarize experience other steroid receptor regulated pathways, i.e. vitamin D, sex , etc.; Discuss with SLIT and compare and contrast its safety/efficacy vs. SCIT; Appreciate recent data management of patients with suspected CS insensitivity and alternative therapeutic describing SLIT; Appreciate methodologic variation in SLIT. strategies for these patients. 5002 Rethinking Allergen Avoidance Q & A Workshop Elizabeth Matsui, MD 5051 Glycobiology and Glycoimmunology: From Euan R. Tovey, PhD Concepts to Clinical Relevance Marriott South Tower, Level 3, Mission Hills 6:45 to 8:00 am Upon completion of this session, participants should be able to: Define current guidelines for allergen avoidance in asthma management; Describe methods of reducing allergen Convention Center, Upper Level, Room 2 exposure and evidence based studies of their effectiveness; Discuss new strategies for Credit: 1.25 CME / 1.50 CE allergen avoidance that take into account the complex interactions between allergens, the Moderator: Nives Zimmermann, MD FAAAAI innate immune system and genetic markers. 6:45 Cell Surface Sialic Acids: The ‘Dark Matter’ of Immune Regulation 5003 Role of Allergy in Atopic Dermatitis Ronald L. Schnaar, PhD Johannes Ring, MD PhD FAAAAI 7:00 Induction of Tolerance by Targeting B Cell Siglecs Marriott South Tower, Level 3, Cardiff James C. Paulson, PhD Upon completion of this session, participants should be able to: Review practical relevance 7:15 Sialic Acid Recognition is Key to Immune Regulation-Role of of aero-food and contact allergic reactions in triggering flairs of AD; List practical tips for Siglecs management with regard to restoring disturbed barrier function in AD. Bruce S. Bochner, MD FAAAAI 5004 Cases of Patients with Chronic Cough 7:30 Question & Answer Mandel R. Sher, MD FAAAAI Upon completion of this session, participants should be able to: Explain sialic acid Gary J. Stadtmauer, MD FAAAAI biosynthesis and its role in human biology; Define the role that glycans play in immune Marriott South Tower, Level 1, Point Loma recognition and regulation. Upon completion of this session, participants should be able to describe various diagnostic and treatment techniques for patients with chronic cough. Problem-Based Learning Workshop 5005 New Insights into IgE Biology 5052 An Allergists' Vision of Ocular Diseases: A Case- Hannah J. Gould, PhD Based Approach Marriott South Tower, Level 1, Solana 6:45 to 8:00 am Upon completion of this session, participants should be able to: Identify the regulation of Convention Center, Upper Level, Room 3 IgE production in B cells; Describe the acquisition of IgE by tissue mast cells; Identify the Pre-registration and ticket required. Fee: $50. effects of IgE activation on tissue mast cells in inflammation. Credit: 1.25 CME / 1.50 CE 5006 Exhaled NO: Time to Clear the Air! PBL Facilitator: Andrew M. Smith, MD FAAAAI Chitra Dinakar, MD FAAAAI Content Lecturer: Neal P. Barney, MD Stanley J. Szefler, MD FAAAAI Upon completion of this session, participants should be able to: Describe the pathophysiol- Marriott South Tower, Level 1, Santa Rosa ogy of ocular conditions commonly encountered in the allergy clinic; Facilitate interaction Upon completion of this session, participants should be able to: Discuss the application of between allergists and ophthalmologists and explain how each plays a complementary eNO in the context of ATS guidelines and AAAAI/ACAAI position statements; Recognize the role in the management of ocular allergy; Discuss allergic diseases which present in relationship between the levels of evidence and practice guidelines for clinical eNO use; different age groups (children, young adults and elderly) and how their diagnoses and Explain potential weaknesses/strengths of eNO for managing asthmatics. management are different. 5007 Perioperative Anaphylaxis: Which Tests and How to Interpret Annual Meeting Workshops Gerald W. Volcheck, MD FAAAAI Marriott South Tower, Level 4, La Costa Programmed by the AAAAI. Annual Meeting Workshops funded Upon completion of this session, participants should be able to explain to patients the through an educational grant from Merck. meaning of allergy tests performed for perioperative anaphylaxis.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 73 TUESDAY, MARCH 4

Q & A Workshop Plenary 5053 Impact of Climate Change on Indoor and Outdoor 5101 Bioaerosols: When Not to Take a Deep Breath at Aeroallergens Work 6:45 to 8:00 am 8:15 to 9:45 am Convention Center, Upper Level, Room 5AB Convention Center, Ground Level, Exhibit Hall A Credit: 1.25 CME / 1.50 CE Credit: 1.50 CME / 1.80 CE Moderator: Estelle Levetin, PhD FAAAAI Moderator: Leslie C. Grammer, MD FAAAAI 6:45 Overview of the Impact of Climate Change 8:15 Office: Building-Related Illness Charles S. Barnes, PhD Jean M. Cox-Ganser, PhD 7:00 Changing Patterns of Aeroallergens and Pollens Around the World 8:45 Agriculture: Respiratory Illness in Large Animal Farming John R. Cohn, MD FAAAAI Environments 7:15 Impacts On the Indoor Environment Jill A. Poole, MD FAAAAI Jonathan A. Bernstein, MD FAAAAI 9:15 Factory: Occupational Illness in the Textile Industry 7:30 Question & Answer David C. Christiani, MD Upon completion of this session, participants should be able to: Identify two recent reports Upon completion of this session, participants should be able to: State the health effects on the impact of climate change on environmental exposures; Describe changes docu- of bioaerosol exposure on health in office building workers; Discuss the immunologic mented to date on indoor and outdoor allergen exposures that have been related to cli- mechanisms of respiratory disease associated with working in large animal confinement mate change adaptation factors; Discuss future factors that might be directly or indirectly feeding operations; Describe bioaerosol sampling methods and exposure risk for health related to climate change and changes in environmental exposures; Discuss appropriate effects in textile manufacturing workers. changes in allergy practice in response to changing environmental exposures. Posters Q & A Workshop 7:00 am to 5:00 pm 5054 Teaching Allergy and Immunology to Residents Convention Center, Ground Level, Exhibit Hall B and Medical Students: An Achievable Goal for the Posters on display from 7:00 am to 5:00 pm. Authors present from 9:45 to 10:45 am. Clinical Allergist Credit: No CME / No CE 6:45 to 8:00 am Refer to pages 83 – 158 for abstracts and authors. Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE 5201 The Impact of Environmental Factors on Asthma Moderator: Mark H. Moss, MD 5202 Diagnostic Modalities of Asthma 6:45 The Six Core Compentencies 5203 Basic and Translational Immunology Asriani M. Chiu, MD FAAAAI 5204 Innate Immunity and Primary 7:00 Designing a Clinical Rotation Lily Pien, MD FAAAAI Immunode!ciencies 7:15 Teaching from a Practitioner’s Perspective: What Works 5205 Epidemiology and Risk Factors of Asthma Stephen A. Tilles, MD FAAAAI 5206 Eosinophilic Gastrointestinal Diseases 7:30 Question & Answer 5207 Drug Allergy Upon completion of this session, participants should be able to: Identify the six core competencies of postgraduate medical training; Describe resources to enhance teaching 5208 Ocular Allergy of trainees in the office setting; Discuss qualities of a clinical rotation that lend value to a medical training program. 5209 Allergen Immunotherapy 5211 Late Breaking Poster Session

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

74 Allied Health Session ticket required fee required included in the Virtual Annual Meeting TUESDAY, MARCH 4

Symposium Symposium 5301 The Road to Allergy: Soluble Instructions to 5304 Angioedema with Negative Family History Dendritic Cells 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Room 11AB Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Michael M. Frank, MD FAAAAI Moderator: Dawn C. Newcomb Baker, PhD 10:45 New Developments in Angioedema Caused by Angiotensin- 10:45 Cysteinyl Leukotrienes are Endogenous Signaling Molecules Converting Enzyme Inhibitors Nora A. Barrett, MD FAAAAI Marco Cicardi, MD PhD 11:05 Inhibition of Th2 Priming by the UDP Receptor P2Y6 11:05 Diagnosis of Idiopathic Angioedema Joshua A. Boyce, MD FAAAAI Marc A. Riedl, MD MS 11:25 Platelets Dictate Th2 Sensitization: The Role of Serotonin 11:25 Management of Idiopathic Angioedema Marco Idzko, MD Aleena Banerji, MD 11:45 Question & Answer 11:45 Question & Answer Upon completion of this session, participants should be able to: Recognize the role cyste- Upon completion of this session, participants should be able to: Discuss mechanisms and inyl leuktrienes play as signaling molecules in dendritic cells; Identify the counterregula- clinical aspects of recurrent angioedema caused by angiotensin-converting enzyme inhibi- tory role of the purinergic 6 receptor; Identify the role of serotonin in Th2 priming. tors; Review the differential diagnosis and management issues of idiopathic angioedema; Describe the management of idiopathic angioedema. Symposium Symposium 5302 What to Do When Everything Fails: Treatment 5305 Innate Cytokines and the Regulation of Allergy Options for Severe Chronic Rhinosinusitis 10:45 am to 12:00 pm 10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 14AB Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Zoulfia Allakhverdi, PhD FAAAAI Moderator: Anju T. Peters, MD FAAAAI 10:45 Role of Epithelial-Derived Cytokines in the Initiation and 10:45 Is More and Longer Better? Long-Term and High-Dose Pathogenesis of Allergy Glucocorticosteroids Clare M. Lloyd, PhD Joaquim Mullol, MD PhD FAAAAI 11:05 Cross-Regulatory Mechanisms of Interferon and Allergic 11:05 Treating With the Cause of Trouble: ASA-Desensitization Stimulation Katharine M. Woessner, MD FAAAAI J. David Farrar, PhD 11:25 The Road to Future: Will Biologics Improve Treatment? 11:25 Modulation of Innate Cytokines by TLR Agonists to Achieve Claus Bachert, MD PhD Tolerance 11:45 Question & Answer Speaker to be announced. Upon completion of this session, participants should be able to: Contrast the limitations 11:45 Question & Answer and possibilities of high-dose or long-lasting glucocorticosteroid treatment in recurrent chronic rhinosinusitis with nasal polyps; Identify suitable patient subgroups, success rates Upon completion of this session, participants should be able to: Identify the key cytokines and limitations of aspirin desensitization; Outline the pathophysiological basis and current secreted by lung epithelial cells in response to infections and the role of these cytokines in knowledge about anti-IgE and anti-IL-5 treatment in nasal polyposis. priming of the allergic condition; Describe the role of type I and III interferons in the sup- pression of Th2 and Th17 responses and the inhibition of interferon secretion by allergic stimulation through the high affinity IgE Fc receptor; Discuss how TLR ligands, such as Symposium CpG oligonucleotides, are being used to mediate allergic suppression through the induc- 5303 Atopic Dermatitis tion of cross-regulatory cytokines. 10:45 am to 12:00 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Lynda C. Schneider, MD FAAAAI 10:45 Barrier Defects in Atopic Dermatitis Anna De Benedetto, MD 11:05 Atopic Dermatitis as a Global Burden Peter Schmid-Grendelmeier, MD PhD 11:25 New Treatment Modalities Mark Boguniewicz, MD FAAAAI 11:45 Question & Answer Upon completion of this session, participants should be able to: Discuss atopic dermatitis; Identify and use appropriate diagnostic tools; Demonstrate efficient, safe and state-of-the- art treatment.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 75 TUESDAY, MARCH 4

Symposium Course 5306 B Cells and Mucosal Immune Responses in Health 5311 Mechanisms of Allergic In&ammation and Disease 10:45 am to 1:45 pm 10:45 am to 12:00 pm Convention Center, Upper Level, Room 4 Convention Center, Mezzanine Level, Room 15AB Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 1.25 CME / 1.50 CE Credit: 2.75 CME / 3.20 CE Moderator: Atsushi Kato, PhD Moderator: Mitchell H. Grayson, MD FAAAAI 10:45 Mucosal Immunity: Balancing Immune Responses at the 10:45 Introduction: Control of Type 2 Immunity Forefront of Microbial Exposure Mitchell H. Grayson, MD FAAAAI Andrea Cerutti, MD 10:50 Transcriptional Cross-Regulation of Th1 and Th2 Cell 11:05 Immunity and B Cells in the Gut: From Immune Exclusion to Food Differentiation Allergy Jinfang Zhu, PhD Cecilia Berin, PhD 11:15 Question & Answer 11:25 B Cells and Respiratory Immunity 11:20 Location, Location, Location: Dendritic Cells, B Cells and Th2 Kathryn E. Hulse, PhD Development 11:45 Question & Answer Frances E. Lund, PhD Upon completion of this session, participants should be able to: Outline how the mucosal 11:45 Question & Answer immune system balances responses to commensal and pathogenic microbes; Describe 11:50 From Friend to Foe: T Regs Acting Th2 the unique role of B cells and their antibodies in maintaining tolerance and homeostasis Prabir Ray, PhD at mucosal sites; Identify how mucosal B cell responses may be dysregulated in allergic disease as a strategy for the development of more targeted therapeutic interventions. 12:15 Question & Answer 12:20 Break Symposium 12:40 Introduction: Novel Concepts in and its 5307 In&ammasome Disorders: Here and Now Receptors Mitchell H. Grayson, MD FAAAAI 10:45 am to 12:00 pm 12:45 Breaking Up is Hard to Do: Disassembly of IgE and FceRI Convention Center, Mezzanine Level, Room 16AB Theodore S. Jardetzky, PhD Credit: 1.25 CME / 1.50 CE Moderator: John W. Steinke, PhD FAAAAI 1:10 Question & Answer 10:45 Nuts and Bolts of Inflammasome Biology 1:15 Exclusivity: IgE Binding to CD23 or FceRI Daniel L. Kastner, MD Hannah J. Gould, PhD Brian Sutton, MA DPhil 11:05 Inflammasome Associated Diseases: The Old and New Monica G. Lawrence, MD 1:40 Question & Answer 11:25 Treatment Options for Inflammasome Disorders Upon completion of this session, participants should be able to: Describe mechanisms through which t-bet is able to suppress Th2 responses and discuss how dendritic cells Hal M. Hoffman, MD FAAAAI and B cells drive Th2 development outside of the T cell zone; Review how a viral respira- 11:45 Question & Answer tory infection can induce Th2 cytokine production from regulatory T cells; Discuss how Upon completion of this session, participants should be able to: Describe the basics of macromolecules can disrupt IgE-FcεRI complexes and how IgE interacts with CD23 and how the inflammasome works; Outline the current state of inflammasome disorders and how this prevents binding to Fc εRI and vice versa. what is new in the field; Discuss novel therapeutic approaches to treating inflammasome disorders.

76 Allied Health Session ticket required fee required included in the Virtual Annual Meeting TUESDAY, MARCH 4

Course Course 5312 Developing Clinical Skills to Promote Adherence 5314 Owning the Bone: How to Minimize and Maximize Asthma Outcomes Glucocorticoid-Induced Osteoporosis Risk 10:45 am to 1:45 pm 10:45 am to 1:45 pm Convention Center, Upper Level, Room 3 Convention Center, Upper Level, Room 8 Pre-registration and ticket required. Fee: $40. Box lunch included. Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 2.75 CME / 3.30 CE Credit: 2.75 CME / 3.30 CE Moderator: Marcus S. Shaker, MD MS FAAAAI Moderator: Joshua A. Steinberg, MD 11:15 Clinical Management Strategies to Promote Adherence of 10:45 Cellular Mechanisms of Glucocorticoid Action in Bone Pediatric Asthma Patients and Families Ernesto Canalis, MD Cynthia S. Rand, PhD 11:15 Bone Biomechanics and Glucocorticoid Effects 11:45 Methods to Diagnose Adherence Status Bjoern Buehring, MD Andrew G. Weinstein, MD FAAAAI 11:45 Break 12:15 Break 12:00 Corticosteroids and Bone Accretion 12:30 Shared Decision Making: A Communication Practice Proven to Kelan Tantisira, MD MPH Enhance Adult Asthma Patients’ Adherence and Outcomes 12:30 Influence of Diet and Lifestyle on Glucocorticoid-Induced Sandra R. Wilson, PhD Osteoporosis 1:00 The Role of Motivational Interviewing to Help Guide Patients to Mary C. Tobin, MD FAAAAI Favorable Asthma Management Actions 1:00 Incorporating Best Bone Health Care into Allergy Practice Belinda Borrelli, PhD Andrea J. Apter, MD MA MSc FAAAAI 1:30 Question & Answer 1:30 Question & Answer Upon completion of this session, participants should be able to: Identify the reasons why Upon completion of this session, participants should be able to: Identify known bone patients are non-adherent with health care providers’ plans; Discuss objective means to health risks of acute and chronic exposure to inhaled and oral glucocorticoids; Recognize diagnose adherence status; Demonstrate motivational interviewing and other patient- differences between GIOP and post-menopausal osteoporosis pathophysiology, risk factors centered techniques to help patients and families follow asthma treatment plans. and screening tools; Discuss present and emerging guidelines and pharmacotherapy in the prevention and management of GIOP. Course Pro/Con Debate 5313 Mechanisms and Treatment of Exacerbations of Asthma 5502 Adaptive Immune Responses are Essential 10:45 am to 1:45 pm 12:30 to 1:30 pm Convention Center, Upper Level, Room 1AB Convention Center, Upper Level, Room 5AB Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 1.00 CME / 1.20 CE Credit: 2.75 CME / 3.30 CE Moderator: Larry Borish, MD FAAAAI Moderators: James E. Gern, MD FAAAAI Pro Daniel J. Jackson, MD Erwin W. Gelfand, MD FAAAAI 10:45 Role of Viruses Con Eva Kathryn Miller, MD Hirohito Kita, MD 11:10 Role of Bacteria Upon completion of this session, participants should be able to discuss the increasingly Hans Bisgaard, MD DMSci important role of ILC2 lymphocytes in generating allergic airway inflammation. 11:35 How Does Allergic Inflammation Alter the Immune Response to Pro/Con Debate Viruses? Peter W. Heymann, MD 5503 Anti-Fungals are E$ective in Treating Allergic 12:00 Break Fungal Airway Disease 12:15 Etiology of Exacerbations in Different Populations 12:30 to 1:30 pm Malcolm R. Sears, MD FAAAAI Convention Center, Upper Level, Room 11AB 12:40 Identifying the Exacerbation-Prone Patient Credit: 1.00 CME / 1.20 CE Ronina A. Covar, MD Moderator: Jeffrey G. Demain, MD FAAAAI 1:05 Approaches to the Prevention and Treatment of Exacerbations Pro Daniel Jackson, MD Daniel L. Hamilos, MD FAAAAI 1:30 Question & Answer Con Upon completion of this session, participants should be able to: List the most common Andrew J. Wardlaw, MD PhD viruses and bacteria associated with asthma exacerbations; Discuss mechanisms of Upon completion of this session, participants should be able to: Identify the clinical trials virus-allergen interactions that promote exacerbations; List major risk factors for exacer- and case series that have described the use of anti-fungals in fungal associated asthma; bations of asthma. List the pros and cons of using anti-fungal agents in ABPA and related conditions.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 77 TUESDAY, MARCH 4

Pro/Con Debate Seminars 5504 The Diagnosis of Asthma vs. COPD Does Not 12:30 to 1:30 pm A$ect Treatment Pre-registration and ticket required. Fee: $40. Box lunch included. Sessions and meals are limited to 30 people. 12:30 to 1:30 pm Credit: 1.00 CME / 1.20 CE Convention Center, Mezzanine Level, Room 14AB Credit: 1.00 CME / 1.20 CE 5521 Approach to the Evaluation of Immunode!ciency Moderator: Michael E. Manning, MD FAAAAI in Adults Pro Adina Kay Knight, MD FAAAAI Stephen P. Peters, MD PhD FAAAAI Joyce E. Yu, MD Con Marriott South Tower, Level 1, Point Loma Nicola A. Hanania, MD Upon completion of this session, participants should be able to: Discuss the workup and Upon completion of this session, participants should be able to: Describe how COPD and management of adults with suspected immunodeficiency; Compare and contrast the dif- asthma can be differentiated; Compare and contrast treatment options and treatment ferential diagnosis for hypogammaglobulinemia in adult patients; List key differences be- expectations in COPD vs. asthma. tween the immunodeficiency diagnostic spectrum in adults vs. adolescents and children. 5522 O#ce Evaluation of Patients with Multiple Pro/Con Debate Antibiotic Allergies 5505 Epinephrine Should be Prescribed to All Allergen Roland Solensky, MD FAAAAI Immunotherapy Patients (SLIT and SCIT) Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to describe how to approach 12:30 to 1:30 pm patients with multiple antibiotic allergies with appropriate diagnostic testing and challenge Convention Center, Mezzanine Level, Room 15AB procedures. Credit: 1.00 CME / 1.20 CE Moderator: Linda Cox, MD FAAAAI 5523 Novel Therapies for Chronic Urticaria and Pro Angioedema Dana V. Wallace, MD FAAAAI David H. Dreyfus, MD PhD FAAAAI Con Marriott South Tower, Level 1, Santa Rosa John Oppenheimer, MD FAAAAI Upon completion of this session, participants should be able to: Discuss novel therapy for chronic urticaria and angioedema; Describe novel diagnostic testing for chronic urticaria Upon completion of this session, participants should be able to: Discuss the safety of SCIT and angioedema; Review practical considerations for application of novel therapy and with emphasis on timing and severity of reactions; Discuss safety of SLIT in the reported diagnosis. studies and surveys. 5524 Tree Nut and Peanut: Complexity in Cross- Pro/Con Debate Reactivity 5506 Androgens are the Best Option for Prophylactic Soheila J. Maleki, PhD Suzanne S. Teuber, MD FAAAAI Treatment of Hereditary Angioedema Marriott South Tower, Level 4, La Costa 12:30 to 1:30 pm Upon completion of this session, participants should be able to: Distinguish between Convention Center, Mezzanine Level, Room 16AB clinical cross-reactivity and in vitro cross-reactivity; List the main seed storage proteins Credit: 1.00 CME / 1.20 CE involved in cross-reactivity; Review the closely related tree nuts that are often clinically Moderator: Bruce L. Zuraw, MD cross-reactive. Pro 5525 Chronic Rhinosinusitis Subtypes and Implications Marco Cicardi, MD PhD for Treatment Con Joseph K. Han, MD Marc A. Riedl, MD MS Amber U. Luong, MD PhD Upon completion of this session, participants should be able to: List the benefits and risks Marriott South Tower, Level 4, Catalina of androgens for prophylaxis in HAE; Discuss the risks and benefits of C1 inhibitor therapy for prophylaxis in HAE; Compare and contrast the use of androgens vs. C1 inhibitor Upon completion of this session, participants should be able to: Describe the classification therapy for prophylaxis in HAE. of sinusitis; Describe the clinical subtypes of chronic rhinosinusitis; Explain the different non-surgical treatment options for the different chronic rhinosinusitis subtypes.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

78 Allied Health Session ticket required fee required included in the Virtual Annual Meeting TUESDAY, MARCH 4

Oral Abstract Oral Abstract 5601 Asthma Epidemiology and Risk Factors 5603 Environmental Risk Factors and Disease 2:00 to 3:15 pm Outcomes Convention Center, Upper Level, Room 5AB 2:00 to 3:15 pm Credit: 1.25 CME / 1.50 CE Convention Center, Upper Level, Room 1AB Moderators: Ronina A. Covar, MD Credit: 1.25 CME / 1.50 CE Timothy J. Craig, DO FAAAAI Jonathan A. Bernstein, MD FAAAAI 2:00 Exposures That Alter The Early Life Microbiome and The Risk Of Moderator: James. L. Sublett, MD FAAAAI Asthma 2:00 Effect Of Prenatal Exposure To Indoor PM2.5 and Environmental Amy S. Feldman, MD Tobacco Smoke Affecting Lower Respiratory Tract Infection Was 2:15 Ethnic Differences Of Reported Asthma Symptoms In Urban Modified By ROS Genes: Cocoa Study School-Based Screening Surveys Song I. Yang, MD Margee Louisias, MD 2:15 IgE Anti-Respiratory Syncytial Virus Antibodies In Older 2:30 Year One Daycare Attendance Predicts Asthma At Age Seven: The Asthmatic Children Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) Mira Mandal Gang Cheng, MD PhD 2:30 Asthma Symptoms and Rhinovirus In A Longitudinal Children’s 2:45 Determining Risk Levels Of The Composite Asthma Severity Index Cohort (CASI) Euan R. Tovey, PhD Rebecca A. Zabel 2:45 Maternal Transfer Of Der p 1 and Blo t 5 Allergens and Their 3:00 BMI and Asthma Severity In An Elementary and Middle School Respective Specific Antibodies Trough Placenta and Colostrum Inner City Population Patricia Macchiaverni Christina G. Kwong, MD 3:00 Rhinovirus Infection Is Associated With Changes In The Airway Upon completion of this session, participants should be able to discuss recent research Microbiome developments in the field of allergy/immunology. Kirsten Kloepfer, MD Upon completion of this session, participants should be able to discuss recent research Oral Abstract developments in the field of allergy/immunology. 5602 Basic and Translational Immunology 2:00 to 3:15 pm Oral Abstract Convention Center, Upper Level, Room 7AB 5604 Eosinophilic Gastrointestinal Diseases Credit: 1.25 CME / 1.50 CE 2:00 to 3:15 pm Moderator: TBA Convention Center, Upper Level, Room 2 2:00 Novel NK Cytotoxicity Assay Enables Drug Discovery For Credit: 1.25 CME / 1.50 CE Hemophagocytic Lymphohistiocytosis Moderator: Antonella Cianferoni, MD PhD Jinzhu Li, MD PhD 2:00 Natural History Of Esophageal Remodeling In Pediatric 2:15 Exploitation Of The Host Ubiquitin System By Respiratory Eosinophilic Esophagitis Treated For Four Years Syncytial Virus Nonstructural Protein 2 Jessica Rajan, MD Jillian N. Whelan 2:15 Diagnostic Inaccuracy Of Biopsy Evaluations In Eosinophilic 2:30 Epigenetic Regulation Of Dendritic Cell Migration Esophagitis Underscores The Value Of a Secondary Review Timothy P. Moran, MD PhD Process 2:45 LRBA Subcellular Localization: Evidence Of The LRBA’s Role Emily Stucke, BA In Vesicle Trafficking From The Golgi To Cell Membrane and 2:30 Development Of Eosinophilic Esophagitis To Food After Endocytosis Development Of IgE Tolerance To The Same Food Michelle A. Reiser, MS Solrun Melkorka Maggadottir, MD 3:00 Differential Role Of Dendritic Cell Subsets In Shaping T-Cell 2:45 Mast Cells, Eosinophils and Eosinophilic Esophagitis Responses To Respiratory Viruses Jay Jin, MD PhD Meera Rani Gupta, MD 3:00 CD3 and CD8 Cells Produce IL-9 In Pediatric Eosinophilic Upon completion of this session, participants should be able to discuss recent research Esophagitis developments in the field of allergy/immunology. Arjun Andrew Anilkumar, BS Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 79 TUESDAY, MARCH 4

Oral Abstract Oral Abstract 5605 Population Health and Food Allergy 5607 Mechanisms of T Cell-Mediated Allergic Disease 2:00 to 3:15 pm 2:00 to 3:15 pm Convention Center, Upper Level, Room 11AB Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Marcus S. Shaker, MD MS FAAAAI Moderator: Taylor A. Doherty, MD FAAAAI 2:00 Longitudinal Effect Of Food Allergy Education On Epinephrine 2:00 TSLP Induces Corticosteroid Resistance In Natural Helper Cells Availability In Public Schools Via STAT5 Pathway Dipika Patel, MD Hiroki Kabata 2:15 Population Response To Change In Infant Feeding Guidelines For 2:15 Impairment Of IL-27’s Differential Effect On CD4+T Cells In Allergy Prevention Asthma Dean Tey, MD Zhihong Chen 2:30 Teasing and Bullying Among Adolescents With Food Allergy 2:30 Profile Of Food Allergen-Specific T Cells In Allergic and Clinically Adora Lin, MD PhD Tolerant Individuals 2:45 Differences In Food Allergy Quality Of Life Between Caregivers In David Chiang, MS a Clinic-Based and a Caregiver-Reported Food Allergic Population 2:45 Follicular Helper T Cells Mediate IgE Antibody Production and Matthew J. Greenhawt, MD MBA MSc Allergic Immune Responses in Mice 3:00 Food Allergy Management In An Urban Pediatric Population Takao Kobayashi, PhD Jennifer M. Camacho, MD 3:00 Analysis Of Circulating Rhinovirus-Specific CD4+ T Cells Using Upon completion of this session, participants should be able to discuss recent research Novel MHC Class II Tetramers Reveals Marked Expansion Of developments in the field of allergy/immunology. Effector Memory Cells In Infected Subjects Lyndsley Muehling Oral Abstract Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology. 5606 New Forms of Immunotherapy 2:00 to 3:15 pm Late Breaking Oral Abstract Session Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE 5611 Clinical Sciences Moderator: Désirée E.S. Larenas Linnemann, MD FAAAAI 2:00 to 3:15 pm 2:00 Persistent Treatment Effect Achieved At One Year After Four Convention Center, Upper Level, Room 8 Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Credit: 1.25 CME / 1.50 CE Epitopes In An Exposure Chamber Model Of House Dust Mite Moderator: Jeffrey G. Demain, MD FAAAAI Allergy Giselle Mosnaim, MD MS FAAAAI Rod Hafner, PhD 2:00 Efficacy and Safety of Lebrikizumab in Severe Uncontrolled 2:15 Treatment With Synthetic Peptide Immuno-Regulatory Epitopes Asthma: Results from the Lute and Verse Phase II Randomized, Derived From Grass Allergens Leads To a Substantial Reduction Double-Blind, Placebo-Controlled Trials In Grass Allergy Symptoms In The Environmental Exposure Unit Nicola A. Hanania, MD Anne K. Ellis, MD MSc FAAAAI 2:15 Dose-Finding Efficacy and Safety Trial of House Dust Mite 2:30 Epicutaneous Immunotherapy Induces Epigenetic Changes In Sublingual Immunotherapy Tablet, MK-8237, Using an Sensitized Mice Environmental Exposure Chamber Lucie Mondoulet, PhD Hendrik Nolte, MD, PhD 2:45 Ultra-Fast Hypoallergenic Birch Pollen Allergy Vaccine Allert Is 2:30 Long-Lasting Egg Consumption in Egg Allergic Children Treated Efficient and Safe: Results Of a Phase IIb Study with Oral Immunotherapy (OIT): Follow-up from the Consortium of Francois Spertini, MD Food Allergy Research (CoFAR) Study 3:00 Stable Conjugates Between A Novel Toll-Like Receptor 7 Ligand Stacie M. Jones, MD and Protein Allergens As Modulators Of Th2 Responses In Vitro 2:45 A Randomized, Double-Blind, Placebo-Controlled Trial of and In Vivo Omalizumab Combined with Oral Immunotherapy (OIT) in the Lucia Fili Treatment of Cow's Milk Allergy (CMA): Safety of Dosing Upon completion of this session, participants should be able to discuss recent research Jennifer S. Kim, MD developments in the field of allergy/immunology. 3:00 Dupilumab Monotherapy in Adults with Moderate-to-Severe Atopic Dermatitis: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study Thomas R.M. Bieber, MD PhD FAAAAI Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

80 Allied Health Session ticket required fee required included in the Virtual Annual Meeting TUESDAY, MARCH 4

Panel Discussion Workshop Q & A Workshop 5801 Improving Inpatient Asthma Outcomes in 5804 Challenges and Interventions to Improve Pediatrics Adherence in Urban Minority Populations with 3:30 to 4:45 pm Asthma Convention Center, Upper Level, Room 5AB 3:30 to 4:45 pm Credit: 1.25 CME / 1.50 CE Convention Center, Upper Level, Room 4 Moderator: Miles M. Weinberger, MD FAAAAI Credit: 1.25 CME / 1.50 CE Panelists: Moderator: Cynthia S. Rand, PhD Amal H. Assa’ad, MD FAAAAI 3:30 Brief-Interval Telephone Surveys of Medication Adherence and Karen M. McDowell, MD Asthma Symptoms In the Chilhood Asthma Management Program Joseph D. Spahn, MD Continuation Study Upon completion of this session, participants should be able to: Utilize questionnaires that Bruce G. Bender, PhD FAAAAI identify need in inpatient asthma care; Identify opportunities to improve outcomes for children with recurrent asthma admissions. 3:45 Problem Solving to Improve Adherence and Asthma Outcomes in Urban Adults with Asthma Panel Discussion Workshop Andrea J. Apter, MD MA MSc FAAAAI 4:00 Use of Mobile Technology to Improve Adherence in Low-Income 5802 The Ins and Outs of Managing Dietary and Minority Adolescents with Asthma Corticosteroid Therapy in Eosinophilic Giselle Mosnaim, MD MS FAAAAI Esophagitis 4:15 Question & Answer 3:30 to 4:45 pm Upon completion of this session, participants should be able to: Discuss barriers to adher- Convention Center, Upper Level, Room 2 ence in urban minority populations with asthma; Discuss the efficacy of a problem solving intervention to improve adherence in urban adults with asthma; Evaluate the efficacy Credit: 1.25 CME / 1.50 CE of an MP3 player and peer support intervention to improve adherence in urban minority Moderator: Dan Atkins, MD FAAAAI adolescents with asthma. Panelists: Juan Pablo Abonia, MD Q & A Workshop Seema Sharma Aceves, MD PhD FAAAAI Katrinia Jane Allen, MD PhD FAAAAI 5805 Allergic In&ammation: New Insights into Key Upon completion of this session, participants should be able to: Identify and discuss is- Innate Mediators sues in the dietary treatment and management of EoE, including the use of an elimination 3:30 to 4:45 pm diet and how to reintroduce foods into the diet; Identify and discuss issues in the use of swallowed topical steroids in the treatment of EoE. Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderator: Steve N. Georas, MD Problem-Based Learning Workshop 3:30 IL33 Dependent Allergic Inflammation via FcgRIII Signalling 5803 Evaluation and Management of Patients with Anne Sperling, PhD Recurrent Infections 3:45 Epithelial Cell-Derived Exosomes in Allergic Airway Inflammation 3:30 to 4:45 pm Nirav Bhakta, MD PhD Convention Center, Upper Level, Room 3 4:00 Innate Type 2 Cytokines and their Receptors in Human Asthma Pre-registration and ticket required. Fee: $50. Morris Ling, MD Credit: 1.25 CME / 1.50 CE 4:15 Question & Answer PBL Facilitator: Vincent R. Bonagura, MD FAAAAI Upon completion of this session, participants should be able to: Explain the importance of Content Lecturer: Mark R. Stein, MD FAAAAI type 2 innate lymphoid cells in mediating the initial steps of allergic inflammation; Review Upon completion of this session, participants should be able to: List the susceptibility the importance of airway epithelial cells and the effect of stress on production of inflam- factors for recurrent infection (immunodeficiency, rhinitis, structural defects, CF); Discuss matory exosomes in allergic airway inflammation; Recognize the importance of innate the role of the diagnostic modalities relevant to the evaluation of patients with recurrent type 2 cytokines and their receptors in human asthma. infection; Outline IgG therapy for immunodeficiency patients.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session ticket required fee required included in the Virtual Annual Meeting 81 TUESDAY, MARCH 4

Year-in-Review Workshop Q & A Workshop 5806 Mechanistic Basis of Food Allergy: New Frontiers 5808 Follicular Helper T Cells in Health and Disease 3:30 to 4:45 pm 3:30 to 4:45 pm Convention Center, Upper Level, Room 11AB Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Credit: 1.25 CME / 1.50 CE Moderator: Kari C. Nadeau, MD PhD FAAAAI Moderator: John W. Steinke, PhD FAAAAI 3:30 Environmental Sanitizers as a Potential Cause of Epidemic Food 3:30 Development of Follicular Helper T Cells Allergy Shane Crotty, PhD Jessica R. , MD 3:45 Vaccines and Follicular Helper T Cells 3:45 Novel iNKT Ligands in Foods: Potential Role in the Development of Michael G. McHeyzer-Williams, PhD Allergy 4:00 The Role of Follicular Helper T Cells in Autoimmunity Patrick J. Brennan, MD PhD Eric Meffre, PhD 4:00 Role of B Cells in Food Allergy Therapy 4:15 Question & Answer Duane R. Wesemann, MD PhD Upon completion of this session, participants should be able to: Discuss how follicular 4:15 Question & Answer helper T cells develop; Describe how vaccines can be used to modulate follicular helper T Upon completion of this session, participants should be able to: Identify the possible role cell function; Describe the mechanisms through which follicular helper T cells participate of sanitizing agents in the pathogenesis of food allergy; Review the importance of innate in the development of autoimmunity. iNKT cell ligands in food allergy; List the principle of B cell receptor editing in the periph- ery and its potential relevance to the control of IgE responses. Problem-Based Learning Workshop Panel Discussion Workshop 5809 A Case of Chronic Severe Urticaria 3:30 to 4:45 pm 5807 Rapid Desensitizations: Protocols and Convention Center, Upper Level, Room 31C Management of Reactions Pre-registration and ticket required. Fee: $50. 3:30 to 4:45 pm Credit: 1.25 CME / 1.50 CE Convention Center, Mezzanine Level, Room 15AB PBL Facilitator: Don A. Bukstein, MD Credit: 1.25 CME / 1.50 CE Content Lecturer: Allen P. Kaplan, MD FAAAAI Moderator: Karen S. Hsu Blatman, MD Upon completion of this session, participants should be able to: Discuss the differential David E. Sloane, MD diagnosis of a patient with chronic severe urticaria; Debate the evaluation of urticaria, including serological, prick skin testing and biopsy interpretation; Discuss novel medical Timothy J. Sullivan, MD and immunomodulatory therapy. Katharine M. Woessner, MD FAAAAI Upon completion of this session, participants should be able to: Identify the safety and efficacy of drug desensitization protocols; Discuss the build up and progression of the available protocols for desensitization; Describe management tools for reactions during drug desensitizations.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

82 Allied Health Session ticket required fee required included in the Virtual Annual Meeting J ALLERGY CLIN IMMUNOL Abstracts AB293 VOLUME 133, NUMBER 2 Scientific Abstract Sessions

Asthma Therapeutics: Advances in Biologics and Patients With Moderate To Severe Asthma With and Without Fixed (FAO) Drugs Randall Brown, MD, MPH , Center for Managing Chronic Disease, University of Michigan School of Public Health, Bradley E. Chipps, 2201 MD, Capitol Allergy and Respiratory Disease Center, Donald P. Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Tashkin, MD, David Geffen School of Medicine at UCLA, Los An- 1 A Rare Presentation Of Surfactant Deficiency In a Term Neo- geles, CA and Frank Trudo, MD, AstraZeneca, Wilmington, DE SATURDAY nate 8 Retrospective Observational Assessment Of Nasal Polyposis In Dr. Nisha N. Shah, MD , LSU Health Sciences Center New Or- Asthmatic Patients Treated With Omalizumab leans, New Orleans, LA, Dr. Heena Shah, MD, Louisiana State Dr. Ana Ant on-Laiseca, MD , Dr. Silvia Mart ınez Blanco, MD, Dr. University, New Orleans, LA and Dr. Kenneth Paris, MD, MPH, Gabriel Gonzalez Salazar, MD, Dr. Maria Carmen Di eguez Pastor, LSU Health Sciences Center, New Orleans, New Orleans, LA MD, Dr. Ruth Mielgo Ballesteros, MD and Dr. Consuelo Fern andez 2 Relapse Of Severe Asthma Exacerbations After Cessation Of Rodrıguez, MD, PhD, Hospital Universitario 12 de Octubre, Omalizumab Treatment – Real Life Data 9 FDA Guidance-Designed Study Of The Effects Of Intranasal Dr. Izabela R. Kuprys-Lipinska, MD, PhD and Prof. Piotr Kuna, Triamcinolone Acetonide Aqueous (TAA-AQ) On Growth Ve- MD, PhD, Dept. of Internal Medicine, Asthma and Allergy, Med- locity (GV) Of Children With Perennial Allergic Rhinitis (PAR) ical University in Lodz, Dr. David P. Skoner, MD , Temple University School of Medicine, 3 Therapeutic Equivalence Of Budesonide/Formoterol (BUD/ Allegheny General Hospital, Pittsburgh, PA; West Penn Allegheny FM) Breath-Actuated Inhaler (BAI) Compared With Bud/FM Health System, Pittsburgh, PA Pressurized Metered-Dose Inhaler (pMDI) In Adults and Ado- 10 Extended Omalizumab Dosage Intervals and Efficacy lescents With Moderate To Severe Asthma Dr. Saraleen Benouni, MD 1, Dr. Lee E. Sheinkopf, MD, Kevin R. Murphy, MD 1, Rajiv Dhand, MD 2, Frank Trudo, MD 3, FAAAAI 2, Dr. LanAnh T. Do, MD, FAAAAI 3, Dr. Asif Rafi, Tom Uryniak, MS 3 and Ajay Aggarwal, MD 3, 1Boys Town Na- MD 2 and Dr. Roger M. Katz, MD, FAAAAI 2, 1UCLA, Los An- tional Research Hospital, Boys Town, NE, 2Department of Medi- geles, CA, 2ucla, los angeles, CA, 3ucla, Los Angeles, CA cine, University of Tennessee Graduate School of Medicine, 11 Effect Of Roflumilast On Asthma Control In Moderate and Se- 3AstraZeneca LP vere Asthma Patients 4 Effects of Budesonide/Formoterol (BUD/FM) Deliverd By Pres- Prof. V.A. Beloglazov 1, Dr. Yuri Popenko 1 and Prof. Lawrence M. surized Metered-Dose Inhaler (pMDI) on Symptoms In African DuBuske, MD, FAAAAI 2, 1Crimean State Medical University, Uk- Americans and Caucasians With Moderate and Severe Asthma raine, 2George Washington University School of Medicine, DC With and Without Fixed Airway Obstruction (FAO) 12 The Potent and Selective CRTH2 Antagonist OC000459 Is Ef- Donald P. Tashkin, MD , David Geffen School of Medicine at fective In The Treatment Of Eosinophilic Asthma When Given UCLA, Los Angeles, CA, Bradley E. Chipps, MD, Capital Allergy Once Daily & Respiratory Disease Center, Sacramento, CA and Frank Trudo, Dr. Roy Pettipher 1, Dr. Michael Perkins 1, Dr. Lisa Pearce Collins 1, MD, AstraZeneca, Wilmington, DE Dr. Mark Baillet 2, Dr. Trevor Lewis 3, Dr. Jan Steiner 4, Prof. John 5 Long-Term Effectiveness Of Omalizumab Treatment In Thai Bell5, Dr. Mark Payton 1 and Dr. Michael Hunter 1, 1Atopix Thera- Severe Asthmatic Patients: A Real-Life Experience peutics, Abingdon, United Kingdom, 2S-Cubed, Abingdon, United Dr. Orapan Poachanukoon, MD , Thammasat University, Pathum- Kingdom, 3TL-Wise Consulting, Cambridge, United Kingdom, tani, Thailand, Dr. Theerasak Kawamatawong, Ramathibodi Hos- 4Oxford Therapeutics Consulting, Brightwell-cum-Sotwell, United paital, Mahidol University, Taiwan, Dr. Atik Saengasapaviriya, Kingdom, 5Medical Sciences Division, Oxford, United Kingdom Phramonkutklao hospital, Thailand, Dr. Chanchai Sittipunt, Chula- 13 Safety and Efficacy Of ARRY-502, a Potent, Selective, Oral longkorn University, Thailand, Dr. Hiroshi Chantaphakul, MD, CRTh2 Antagonist, In Patients With Mild To Moderate Th2- FAAAAI, Chutuchak District, Chulalongkorn University Hospital, Driven Asthma Bangkok, Thailand, Prof. Kittipong Maneechotesuwan, Siriraj hos- Sally E. Wenzel, MD, FAAAAI 1, Robert Hopkins, Director of pital, Mahidol university, Bangkok, Thailand, Dr. Pintip Ngamcha- Clinical Operations2, Dr. Michael Saunders, MD, Senior Director nyaporn, Ramathibodi Hospital, Mahidol University, Thailand, Dr. of Drug Safety 2, David Chantry, Senior Director of Translational Kunchit Piyavechviratana, Pramongkut Hospital, Sathorn, Thai- Medicine and Cell Biology2, Lisa Anderson, Clinical Research land, Dr. Apichart Khanisap, Thammasat University Hospital, Manager2, Roger Aitchison, Senior BioStatistician 2, Christine Thailand, Dr. Siwasak Juthong, Faculty of Medicine, Songklanak- Eberhardt, Research Investigator 2, Stacie Bell, Director of Clinical rin University, Thailand, Dr. Warangkana Rithirak, Songklanakar- Pharmacology2, Dr. Jeremy Cole, MD, Principal Investigator 3, Dr. ind University, Thailand, Dr. Chaicharn Pothirat, Chiangmai James Wolfe, MD, Physician/Research Investigator 4, Dr. Sheldon University, Thailand and Dr. Watchara Boonsawat, Srinagarind L. Spector, MD, FAAAAI 5, Dr. Lawrence D. Sher, MD, FAAAAI 6, Hospital, Thailand Dr. Edward M. Kerwin, MD, FAAAAI 7 and Dr. Larry Burgess, 6 Role Of Monoclonal Antibody In Sickle Cell Disease Patients PhD, Executive Director of Medicinal Chemistry 2, 1University of With Allergic Rhinitis and Asthma Along With Raised IgE Pittsburgh Medical Center NW, Pittsburgh, PA, 2Array BioPharma Level Inc., Boulder, CO, 3IPS Research Company, Oklahoma City, OK, Dr. Abdul Rehman Syed, MD , King Fahad University Hospital 4Allergy & Asthma Associates of Santa Clara County Research Khobar, Dammam, Saudi Arabia Center, San Jose, CA, 5California Allergy & Asthma Medical 7 Effects Of Long-Term Treatment With Budesonide/Formoterol Group, Los Angeles, CA, 6Peninsula Research Associates, Rolling (BUD/FM) Delivered By Pressurized Metered-Dose Inhaler Hills Estates, CA, 7Allergy and Asthma Center of Southern OR, (pMDI) On Symptoms In African-American and Caucasian Medford, OR

83 AB294 Abstracts J ALLERGY CLIN IMMUNOL

SATURDAY FEBRUARY 2014

14 A Phase I Assessment Of Safety and Tolerability Of RNS60, a 19 Test-Retest Reliability Of The ISAAC Questionnaire For a Novel Therapeutic Containing Charge-Stabilized Nanostruc- Web-Based Study tures In Asthma Dr. Koichi Yoshida, MD 1, Dr. Yuichi Adachi, MD, PhD 2, Dr. Mari Supurna Ghosh, PhD , Andreas Kalmes, PhD, Jarrad Mock, Jocelyn Sasaki, MD 1, Dr. Mayumi Furukawa, MD 1, Dr. Toshiko Itazawa, Sutherland and Richard Watson, MD, Revalesio Corporation, WA MD, PhD2, Dr. Koji Hashimoto, MD, PhD 3, Dr. Hiroshi Odajima 4 15 Tiotropium Respimat Ò Add-On To Inhaled Corticosteroids Im- and Dr. Akira Akasawa, MD, PhD 1, 1Division of Allergy, Tokyo proves Lung Function In Patients With Symptomatic Mild Metropolitan Children’s Medical Center, Tokyo, Japan, 2Depart- Asthma: Results From A Phase III Trial ment of Pediatrics, University of Toyama, Toyama, Japan, 3Depart- Pierluigi Paggiaro1, Dr. David M.G. Halpin, MD 2, Roland Buhl 3, ment of Pediatrics and Child Health, Nihon University School of Dr. Michael Engel, MD 4, Valentina Zubek 5, Zuzana Blahova 6, Dr. Medicine, Tokyo, Japan, 4Fukuoka National Hospital, Fukuoka, Petra Moroni-Zentgraf4 and Dr. Emilio Pizzichini 7, 1University of Japan Pisa, Pisa, , 2Royal Devon & Exeter Hospital, Exeter, United 20 Characteristics Of Adolescents With Undiagnosed Asthma In Kingdom, 3Mainz University Hospital, Mainz, Germany, 4Boeh- Rural Counties In Georgia ringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Dr. Poneh Davoodi, MD 1, Dr. Dennis Ownby, M.D. FAAAAI 2, Germany, 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Ms. Suzanne Havstad, M.A. 3, Dr. Jennifer Waller, PhD 4, Dr. Chris- CT, 6Boehringer Ingelheim RCV GmbH & Co. KG, , Aus- tine L.M. Joseph, PhD3 and Dr. Martha Tingen, PhD 4, 1Georgia Re- tria, 7NUPAIVA (Asthma Research Centre), Universidade Federal gents University, 2Division of Allergy-Immunology and de Santa Catarina, Florian opolis, Brazil Rheumatology, Georgia Regents University, Augusta, GA, 3Depart- 16 Tiotropium Respimat Ò Add-On Therapy Reduces Airflow Ob- ment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, struction In Patients With Symptomatic Moderate Asthma, In- 4Georgia Regents University, Augusta, GA

dependent Of T H2 Inflammatory Status 21 Trends In Prevalence Of Asthma and Allergies In 13-14 Year Dr. Thomas B. Casale, MD, FAAAAI 1, Dr. Eric Donn Bateman, Old Children Between Two ISAAC Studies In Birjand City, MD 2, Prof. Ronald Dahl, MD 3, Dr. Emilio Pizzichini 4, Dr. Mark Iran L. Vandewalker, MD 5, Dr. Johann Christian Virchow 6, Dr. Michael Dr. Mohammad Fereidouni, MD, PhD , Asthma, Allergy & Im- Engel, MD 7, Dr. Petra Moroni-Zentgraf 7, Dr. Hendrik Schmidt 8 and munology Research Center,Birjand University of Medical Sciences, Huib A.M. Kerstjens 9, 1Univeristy Of South Florida Morsani Col- Iran and Mrs. Shaghayeghsadat Nourani hassankiadeh, birjand uni- lege Of Medicine, Tampa, FL, 2University of Cape Town Lung In- versity of medical sciences stitute, Cape Town, South Africa, 3Odense University Hospital, 22 An Evaluation Of The Thai-Translated Version Of The Child- Odense, Denmark, 4NUPAIVA (Asthma Research Centre), Univer- hood Asthma Control Questionnaire (C- ACT) and The Com- sidade Federal de Santa Catarina, Florian opolis, Brazil, 5Clinical posite Asthma Severity Index (CASI) Among Thai Asthmatic Research of the Ozarks, Columbia, MO, 6University Clinic Ro- Children stock, Rostock, Germany, 7Boehringer Ingelheim Pharma GmbH Dr. Benjarat Dardaranonda, MD , Department of Pediatrics, Fac- & Co. KG, Ingelheim Am Rhein, Germany, 8Boehringer Ingelheim ulty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Pharma GmbH & Co. KG, Biberach an der Riss, Germany, 9Uni- THAILAND, Bangkok, Thailand versity Medical Center Groningen, University of Groningen, Gro- 23 Impact Of Change In Inhaled Corticosteroids/Long-Acting ningen, Netherlands Beta Agonist Combination (ICS/LABA) Use On The Risk Of 17 Once-Daily Tiotropium Respimat Ò Improves Lung Function In Asthma Exacerbations In Asthma Patients Within a Medical Patients With Severe Symptomatic Asthma Independent Of Group Modifier Use Dr. Richard H. Stanford, PharmD, MS 1, Saurabh Nagar, MS 1, Prof. Ronald Dahl, MD 1, Prof. Dennis E. Doherty 2, Jonathan Cor- Dr. Xiwu Lin, PhD 1 and Dr. Dick O’Connor, MD 2, ren, MD 3, Dr. Jill Karpel 4, Huib A. M. Kerstjens 5, Dr. Michael En- 1GlaxoSmithKline, 2Sharp Rees-Stealy Medical Group, San gel, MD 6, Dr. Petra Moroni-Zentgraf 6, Dr. Hendrik Schmidt 7 and Diego, CA Dr. Shu Hashimoto, MD, PhD 8, 1Odense University Hospital, 24 HLA-DRB1 Alleles, Levels Of Total IgE and IL-13 In Patients Odense, Denmark, 2Lexington VA Medical Center, University of Of Bronchial Asthma From A Local Tertiary Care Hospital In Kentucky, Lexington, KY, 3University of California, Los Angeles, , Mr. Khursheed Javaid, M.Phil. , University of CA, 4North Shore Medical Arts LLP, Great , NY, 5University Health Sciences, Lahore, Pakistan Medical Center Groningen, University of Groningen, Groningen, 25 Infectious Asthma Trigger, Acq Score and Minirqlq Score Cor- Netherlands, 6Boehringer Ingelheim Pharma GmbH & Co. KG, In- relations Support The One Airway Hypothesis gelheim Am Rhein, Germany, 7Boehringer Ingelheim Pharma Dr. Amy Virojanapa, MD 1, Ms. Phoebe Shah 2, Mr. Arthur GmbH & Co. KG, Biberach an der Riss, Germany, 8Nihon Univer- Omondi1 and Dr. Efren L. Rael, MD, FAAAAI 3, 1Penn State, Her- sity School of Medicine, Tokyo, Japan shey Medical Center, Hershey, PA, 2UC San Diego, Vista, CA, 3Al- lergy/Immunology, Penn State University College of Medicine, Hershey, PA

Asthma Epidemiology

2202 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Primary Antibody Deficiencies 18 Close Correlation Between Month Of Birth and The Prevalence Of Bronchial Asthma In Schoolchildren In a Taiwanese Popula- 2203 tion Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Prof. Ho-Chang Kuo , Kaohsiung Chang Gung Memorial Hospital 26 Comprehensive Immunological and Clinical Features Of Com- and Chang Gung University, Kaohsiung, Taiwan, Prof. Wei-Chiao mon Variable Immunodeficiency (CVID) Chang, Taipei Medical University, Prof. Kuender D. Yang, Show Dr. Varaz Bozoghlanian, MD 1, Sudhanshu Agrawal, MS 2 and Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan Sudhir Gupta, MD, PhD, FAAAAI 1, 1University of California, Ir- and Prof. Wei-Pin Chang, Yuanpei University, Taiwan vine, Irvine, CA, 2University of California, Irvine

84 J ALLERGY CLIN IMMUNOL Abstracts AB295 VOLUME 133, NUMBER 2

27 Clinical, Immunological and Genetic Spectrum Of Novel BTK Rubinstein, MD, FAAAAI, Albert Einstein College of Medicine, Gene Mutations In X-Linked Agammaglobulinemia Patients Bronx, NY and Female Carriers 39 Selective IgM Deficiency Presenting As Cryptogenic Organiz- Dr. Regan Pyle, DO 1, Dr. John B. Hagan, MD, FAAAAI 1, Amanda ing Pneumonia Martinez, MS 1, Dr. Avni Y. Joshi, MD 1, Dr. Thomas Boyce, MD 1, Dr. Cory A. Lundberg, DO 1, Dr. Taylor A. Banks, MD 1, Dr. Ce- Dr. Gerald W. Volcheck, MD, FAAAAI 2, Dr. Yesim Yilmaz-Demirdag, cilia Mikita, MD, MPH FAAAAI 2 and Dr. Jeffrey Mikita, MD 1, MD 3, Prof. Sami L. Bahna, MD DrPH FAAAAI 4 and Dr. Roshini S. 1Walter Reed National Military Medical Center, Bethesda, MD, Abraham, PhD FAAAAI 1, 1Mayo Clinic,Rochester, MN, 2Mayo Clinic 2Walter Reed Army Medical Center, Bethesda, MD and Foundation, Rochester, MN, 3Columbia University, New York, NY, 42 High Prevalence Of In Children With Primary 4LA State University Health Sciences Center, Shreveport, LA Immunodeficies 28 CD19 +CD27+CD43+CD70-CD5- B-1b Cells In Children With Dr. Celia Pinto Fernandez 1, Dr. Mar ıa Dolores Gurbindo Guti er- Specific Antibody Deficiency, Specific Antibody Deficiency rez1, Dr. Jose Manuel Zubeldia Ortuno, MD, PhD 2 and Dr. Mar ıa

With Decreased IgG, and Common Variable Immunodeficiency Elena Seoane Reula1, 1Gregorio Maran~on Universitary Hospital, SATURDAY Dr. Kathryn D. Convers, MD 1,2, Barbara Kariuki, MPH 1 and Dr. Madrid, Spain, 2Hospital Gregorio Maranon, Madrid, Spain Alan Knutsen, MD, FAAAAI 1,2, 1Saint Louis University School of 43 Three Cases Of Good’s Syndrome Medicine, Saint Louis, MO, 2Cardinal Glennon Children’s Medical Dr. Whitney M. Rassbach, MD , Mount Sinai School of Medicine, Center, Saint Louis, MO New York, NY and Dr. Charlotte Cunningham-Rundles, MD, PhD, 29 A Devastating Outcome In Undiagnosed X-Linked Agamma- FAAAAI, Mt. Sinai Medical Center, New York, NY globulinemia— A Call For Earlier Screening 44 Immunological Analysis Of Primary Selective IgM Deficiency Dr. Karen Elizaeth Bruner, MD , Wilford Hall Ambulatory Surgi- In Adults cal Center, Lackland AFB, TX and Dr. Anthony , MD, PhD, Ankmalika Louis, MD , UNIVERSITY OF CALIFORNIA, IR- UT Health Science Center San Antonio, San Antonio, TX VINE, CA, Sudhanshu Agrawal, MS, University of California, Ir- 30 Genetic Basis Of CVID-Like Disease vine and Sudhir Gupta, MD, UNIVERSITY OF CALIFORNIA, Dr. Kate Welch, MD , Mt. Sinai Medical Center, Dr. Elena Re- IRVINE snick, MD, Mount Sinai School of Medicine, New York, NY and 45 A Rare Case Of Helicobacter Cellulitis In a Patient With X- Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI, Mt. Sinai Linked Agammaglobulinemia Medical Center, New York, NY Dr. Nina Lakhani, MD 1, Dr. Linda R. Taggart 2, Dr. Henry Jaku- 31 A Case Of A CVID Patient and Rabies Exposure bovic3, Dr. Stephen D. Betschel, MD 1 and Dr. Zafir Hussain 4, Dr. Hassan Nasir, DO , Nova Southeastern University College of 1University of Toronto, Division of Clinical Immunology and Al- Osteopathic Medicine, Davie, FL; Larkin Community Hospital, lergy, Toronto, ON, Canada, 2University of Toronto, Divison of In- Miami, FL and Dr. Shahnaz Fatteh, Larkin Community Hospital, fectious Diseases, Toronto, 3University of Toronto, Division South Miami, FL of Laboratory Medicine and Pathology, Toronto, ON, Canada, 32 Common Variable Immunodeficiency In The Very Old 4University of Toronto, Division of Microbiology, Toronto, ON, Dr. Katherine E. Gundling, MD , UCSF, San Francisco, CA Canada 33 Clinical Predictors Of Granulomatous Disease In Common 46 Neuropathy In Patients With Underlying Immunodeficiency Variable Immunodeficiency Syndrome Dr. Anna R. Wolfson and Dr. Anna Kovalszki, Beth Israel Deacon- Dr. Robyn Kreiner, MD and Dr. Arye Rubinstein, MD, FAAAAI, ess Medical Center, Boston, MA Albert Einstein College of Medicine, Bronx, NY 34 Jacobsen Syndrome With Combined Variable Immunoddefi- ciency (CIVD) Dr. Arnaldo C. Porto Neto, MD, PhD, FAAAAI , Dr. Julio Mella Pierezan, Student, Dr. Joao Paulo Bordin, Student, Dr. Julia Noschang, Dr. Juliana Gotardo, Student, Dr. Juliana Moro, Student, Dr. Jorge Asthma Epidemiology, Risk Factors, and Public Luigi Orso, Student, Dr. Jamile Pedroni, Student and Dr. Jessica Zan- dona, Student, School of Medicine UPF, PASSO FUNDO, Brazil Health I 35 Factors Predicting Long-Term Hypogammaglobulinemia In Survivors 2204 Dr. Huifang Lu, MD, PhD , UT MD Anderson Cancer Center, Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Houston, TX and Dr. Xerxes Pundole, UT MD Anderson Cancer 47 Allergic Sensitization and Enviromental Exposures In Amish Center and Hutterite Children 36 Assessment Of Benefits Of Scig Valued By Healthcare Pro- Dr. Mark Holbreich, MD, FAAAAI 1, Ms. Michelle Stein, MS 2, viders and Patients: Survey Results Ms. Rebecca Anderson, MS 3, Dr. Nervana Metwali, PhD 4, Dr. Ms. Annette R. Zampelli, NP 1, Ms. Carla M. Duff, CPNP MSN 2 Peter S. Thorne, PhD 4, Dr. Donata Vercelli, MD 5, Dr. Erika and Dr. Ann Bullinger, PharmD 1, 1CSL Behring, LLC, King of Von Mutius, MD, MSc 6 and Dr. Carole Ober, PhD 3, 1Allergy Prussia, PA, 2University of South Florida, Tampa, FL and Asthma Consultants, Indianapolis, IN, 2The University of 37 Pneumococcal Titer Levels: Comparison Of Patients Receiving Chicago, Chicago, IL, 3University of Chicago, Chicago, IL, Intravenous Immunoglobulin Vs. Subcutaneous Immunoglobulin 4University of Iowa, Iowa City, IA, 5The University of Dr. Pamella Abghari, MD 1,2 , Dr. Elizabeth A. Secord, MD, Arizona, Tucson, AZ, 6University Children’s Hospital, Munich, FAAAAI 1,2 and Dr. Pavadee Poowuttikul, MD 1,3 , 1Children’s Hospital Germany of Michigan Department of Allergy Immunology, Detroit, 48 Association Between Asthma-Related Emergency Department MI, 2Wayne State University, Detroit, MI, 3Pediatrics- Allergy/Immu- Visits, Tree Pollen, Pollution and Humidity In The Bronx, nology Division, Wayne State University School of Medicine, Detroit, 2001 - 2008 MI Dr. Jennifer Toh, MD 1, Dr. Mili Shum, MD 2,3, Dr. Gabriele De 38 Hypogammaglobulinemia, Multiple Sclerosis, and Treatment Vos, MD 4, Tulsi Desai 4, Priyank Patel 4, Dr. Sunit Jariwala, MD 1 With Intravenous Gammaglobulin and Dr. David L. Rosenstreich, MD, FAAAAI 5, 1Albert Einstein/ Dr. Tiffany Dy, MD , Montefiore Medical Center at Albert Montefiore Medical Center, New York, NY, 2Montefiore Medical Einstein College of Medicine, Bronx, NY and Dr. Arye Center, Bronx, NY, 3Weill Cornell Medical College, New York,

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NY, 4Albert Einstein College of Medicine, Bronx, NY, 5Albert Ein- MD, 6AAIB\DAIT\NIH, Bethesda, MD, 7University of Wisconsin stein/Montefiore Medical Center, Bronx, NY School of Medicine and Public Health, Madison, WI 49 Association Of Wheezing Illness With Respiratory Viruses In 56 Genetic Determinants Of Allergic Sensitization To Cockroach Hospitalized Jordanian Children Allergen In Children Olajumoke Fadugba, MD 1, Eva Kathryn Miller, MD 2, Najwa Priya Tripathi, PhD 1, Xiumei Hong, PhD 2, Deanna , MS 2, Khuri-Bulos, MD, FIDSA, CIC3, Samir Faouri, MD 3, Asem She- Peisong Gao, MD, PhD1 and Dr. Xiaobin Wang, MD, MPH ScD 2, habi, PhD4, Christopher Fonnesbeck, PhD 1, Li Wang, MS 1, John 1Division of Allergy & Clinical Immunology, Johns Hopkins Uni- V. Williams, MD 1 and Natasha Halasa, MD, MPH1, 1Vanderbilt versity School of Medicine, Baltimore, MD, 2Johns Hopkins Uni- University Medical Center, Nashville, TN, 2Pediatric Allergy, Im- versity School of Public Health, Baltimore, MD munology, and Pulmonary Medicine, Vanderbilt University Medi- 57 Exhaled Nitric Oxide (FeNO) and Dust Mite (Der p1) Exposure cal Center, Nashville, TN, 3Jordan University Hospital, Jordan, Are Significantly Higher In Asthmatic Children Living In Hu- 4University of Jordan, Jordan mid Environments 50 The Effect Of Obesity On Asthma Control As Measured By Dr. Miguel J. Lanz, MD, FAAAAI 1, Benjamin Efaw 2, Mirna Gon- The Asthma Control Test zalez1 and Dr. Ronald J. Harbeck, PhD 2, 1AAADRS Clinical Re- Dr. Aerik A. Williams, MD, MPH 1, Dr. Mark S. Dykewicz, MD, search Center, Coral Gables, FL, 2National Jewish Health, FAAAAI 2 and Dr. Jason W. Caldwell, DO, FAAAAI 1, 1Wake For- Denver, CO est University Baptist Medical Center, Winston Salem, NC, 2Saint Louis University School of Medicine, St. Louis, MO 51 Perception Of Asthma Control Is Not Consistent With Re- ported Symptom Frequency In Urban Adolescents Emily C. Ledford , Johns Hopkins School of Medicine, Ms. Jean Aerobiology I Curtin-Brosnan, MA, Johns Hopkins University, Baltimore, MD, Dr. Meredith C. McCormack, MD, The Johns Hopkins Pulmonary, 2205 Baltimore, MD and Dr. Elizabeth Matsui, MD, The Johns Hopkins Saturday, March 1st, 2014, 9:45 AM - 10:45 AM University School of Medicine, Baltimore, MD 58 Extraordinary Alternaria Mold Counts During a Severe 52 Urban Residence Modifies The Association Between Atopy and Drought Wheeze Mr. James J. Anderson, MLT , Environmental Allergy/Oshtech, Dr. Pablo F. Endara 1, Dr. Phil J. Cooper 2,3, Thomas A.E. Platts- London, ON, Canada and Dr. Linda B. Ford, MD, FAAAAI, The Mills, MD, PhD, FAAAAI 4, Lisa J. Workman, BA 4, Maritza Asthma & Allergy Center, P.C., Bellevue, NE Vaca 5, Dr. Martha Chico 6, Mauricio L Barreto, PhD 7 and Prof. 59 Culture Of The House Dust Mite Euroglyphus Maynei To Pro- Laura Rodrigues8, 1Universidad San Francisco de Quito, 2St. duce Allergen Material George’s University, London, United Kingdom, 3Pontificia Univer- Dr. Larry G. Arlian, PhD FAAAAI , DiAnn L. Vyszenski-Moher, sidad Catolica del Ecuador, 4Division of Asthma, Allergy & Immu- MS, Dr. Marjorie S. Morgan, PhD and Jacqueline Neal, MS, Wright nology, University of Virginia Health System, Charlottesville, VA, State University, Dayton, OH 5Laboratorio de FEPIS, Quinind e, Esmeraldas Province, Ecuador, 60 Emergency Department Visits For Asthma As a Function Of 6Laboratorio de Investigacion FEPIS, 7Instituto de Sa ude Coletiva, Pollen and Mold Spore Counts UFBa, Salvador, BA, Brazil, 8London School of Hygiene and Trop- Dr. Stacey Galowitz, DO 1,2, Dr. Christopher Chang, MD, PhD, ical Medicine FAAAAI 1 and Mr. Michael R. McDowell 3, 1Alfred I duPont Hospital 53 Allergic Inflammation and Health Outcomes Of Comorbid for Children, Wilmington, DE, 2Thomas Jefferson University Hospi- Asthma and Obesity In Inner-City Black and Hispanic School- tal, Philadelphia, PA, 3Air Quality Management, New Castle, DE children 61 Daily Ragweed Pollen Forecasting Dr. Perdita Permaul, MD 1,2, Dr. William J. Sheehan, MD 2,3, Mr. Estelle Levetin, PhD FAAAAI 1 and Lauren Howard, B.S. 1,2, 1Uni- Carter Petty, MA 3, Dr. Sachin N. Baxi, MD 2,3, Dr. Jonathan M. versity of Tulsa, Tulsa, OK, 2University of Oklahoma, Oklahoma Gaffin, MD, MMSc2,3, Dr. Lianne S. Kopel, MD 2,3, Dr. Watcharoot City, OK Kanchongkittiphon, MD, PhD3, Mrs. Chunxia Fu, MS 4, Dr. Diane 62 Conditions Affect Dust Mite Infestation Of Flour Samples In R. Gold, MD, MPH 2,4 and Dr. Wanda Phipatanakul, MD, MS, Tropical Area FAAAAI 2,3, 1Division of Pediatric Allergy/Immunology, Massa- Dr. Theerapan Songnuy , Allergy and Immunology Division, Chu- chusetts General Hospital, Boston, MA, 2Harvard Medical School, lalongkorn University Medical School, Bangkok, Thailand Boston, MA, 3Boston Children’s Hospital, Boston, MA, 4Channing 63 Airborne Alternaria Spore Levels In Kansas City Is Associated Laboratory, Brigham and Women’s Hospital, Boston, MA With Climatic Changes 54 Targeted Education Of Adult Patients From An Inner City Dr. David A. Jara, MD 1, Dr. Charles Barnes, PhD 2, Dr. Jay M. Population At Risk For Non-Adherence With Asthma Therapy Portnoy, MD, FAAAAI 2 and Dr. Minati Dhar, Ph.D 3, 1Childrens Dr. Edan Sarid, MD , SUNY Downstate Medical Center, Center Mercy Hospital, 2Children’s Mercy Hospital, Kansas City, MO, for Allergy and Asthma Research, Brooklyn, NY and Dr. Rauno 3Children’s Mercy Hospital & Clinics, Kansas City, MO Joks, MD, Center for Allergy and Asthma Research at SUNY 64 Influence Of Meteorological Conditions On Mountain Cedar Downstate, Brooklyn, NY Pollen 55 Maternal Allergy and Asthma and Their Association With Landon Bunderson, PhD1,2, Peter Van De Water, PhD 3, Jeffrey Breastfeeding In Inner-City Mothers In a Birth Cohort Study Luvall, PhD4 and Estelle Levetin, PhD FAAAAI 2, 1Iowa State Uni- (URECA) versity, Ames, IA, 2University of Tulsa, Tulsa, OK, 3California Katy F. Jaffee, MS 1, Dr. Cynthia Visness, PhD 1, Dr. George T. State University, Fresno, Fresno, CA, 4NASA Marshall Space O’Connor, MD 2, Dr. Gordon R. Bloomberg, MD, FAAAAI 3, Dr. Flight Center, Huntsville, AL Meyer Kattan, MD 4, Robert A. Wood, MD, FAAAAI 5, Dr. Peter 65 A Post-Hoc Qualitative Analysis Of Real Time Heads-Up Pollen J. Gergen, MD, MPH 6 and Dr. James E. Gern, MD, FAAAAI 7, Counting Versus Traditional Microscopic Counting In The En- 1Rho, Inc., Chapel Hill, NC, 2Boston University School of Medi- vironmental Exposure Unit (EEU) cine, Boston, MA, 3Campus Box 8116, St. Louis Children’s Hospi- Ms. Lisa Steacy, BSc 1, Mr. Terry Walker, BA 1, Mr. Barnaby Hobs- tal, Saint Louis, MO, 4NewYork-Presbyterian/Columbia, New bawn 1, Mrs. Jenny Thiele, MSc 2 and Dr. Anne K. Ellis, MD, MSc York, NY, 5Johns Hopkins University Medical Center, Baltimore, FAAAAI 1,3, 1Allergy Research Unit, Kingston General Hospital,

86 J ALLERGY CLIN IMMUNOL Abstracts AB297 VOLUME 133, NUMBER 2

Kingston, ON, Canada, 2Queens University, Kingston, ON, Canada, 2Cornell University, 3Icahn School of Medicine at Mount Sinai, 3Departments of Medicine and Biomedical & Molecular Science, New York, NY Queen’s University, Kingston, ON, Canada 73 Factors Associated With Increased Risk Of Anaphylaxis 66 Real-Time PCR Quantification Of Virginia Live Oak (Quercus Aylin Altan Riedel, PhD 1, Erin Buysman, MS 1, Dr. Ray A. Wolf, virginiana) Pollen PharmD2, Paul Cavanaugh, Jr, PhD 3, Jerald Seare, MD 1 and Tim Dr. Mark C. Glaum, MD, PhD, FAAAAI 1,2, Ms. Eileen Rifkin 1, Bancroft, PhD1, 1OPTUM, Prairie Eden, MN, 2Mylan Specialty Dr. Jia-Wang Wang, PhD 1, Dr. Richard F. Lockey, MD 1,2 and Dr. L.P., New Hope, PA, 3Mylan Specialty, Basking Ridge, NJ Dennis K. Ledford, MD, FAAAAI 1,2, 1Division of Allergy and Im- 74 A Face-To-Face Educational Program By Allergists Can Im- munology, Department of Internal Medicine, University of South prove Knowledge, Attitudes, and Behaviors (KAB) Of Internal Florida, Morsani College of Medicine, Tampa, FL, 2James A. Haley Medicine, Pediatric, and Emergency Medicine Residents Veterans’ Affairs Hospital, Tampa, FL Dr. Artemio M. Jongco III, MD, PhD MPH , Feinstein Institute 67 Unusual Timing For The Ragweed Ambrosia Pollen Peak In for Medical Research, Manhasset, NY; Cohen Children’s Medical

Vinnitsa, Ukraine Center of New York, Great Neck, NY, Dr. Sheila Bina, MD, Stony SATURDAY Ms. Viktoria Rodinkova 1, Ms. I Motruk 1, Ms. L. Slobodianiuk 1, Brook University Hospital, Stony Brook, NY, Dr. Robert Sporter, Ms. O. Mazur 1, Ms. O. Palamarchuk 1 and Prof. Lawrence M. Du- MD, Division of Allergy/Immunology, Departments of Medicine Buske, MD, FAAAAI 2, 1Vinnitsa National Pirogov Memorial Med- and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Dr. ical University, Ukraine, 2George Washington University School of Marie A. Cavuoto Petrizzo, MD, FAAAAI, ProHealth Care Asso- Medicine, DC ciates LLP, Lake Success, NY, Dr. Blanka M. Kaplan, MD, FAAAAI, Department of Pediatrics, Division of Allergy & Im- munology, Hofstra-North Shore-LIJ School of Medicine, Great Neck, NY and Dr. Susan Schuval, MD, FAAAAI, Stony Brook U Medical Cente, Stony Brook University Medical Center, Stony Insect Hypersensitivity/Anaphylaxis Brook, NY 75 Anaphylaxis Management Before and After Implementation Of 2206 Guidelines In The Pediatric Emergency Department Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Dr. Shilpa Desai 1, Dr. Rhett Lieberman 1, Stephen Wisniewski, 68 Safety and Efficacy Of a 12-Week Maintenance Interval In Pa- PhD2 and Dr. Todd David Green, MD, FAAAAI 1, 1Children’s Hos- tients Treated With Imported Fire Ant Immunotherapy pital of Pittsburgh of UPMC, Pittsburgh, PA, 2University of Dr. Karla E. Adams, MD 1, Dr. Shayne Stokes, MD 2, Dr. Kevin M. Pittsburgh White, MD 1, Dr. Kirk H. Waibel, MD, FAAAAI 3 and Dr. 76 Managing Anaphylaxis In Adults: A Review Of All Cases Pre- Michael S. Tankersley, MD, FAAAAI 4, 1Wilford Hall Ambulatory senting In A Single Year At An Emergency Department Surgical Center, Joint Base San Antonio, Lackland AFB, TX, Dr. Yarden Yanishevsky, MD 1, Dr. Ann Elaine Clarke, MD, MSc 2,3, 2Luke AFB, Glendale, AZ, 3Landstuhl RMC, 4Wilford Dr. Sebastian La Vieille, MD 4, Dr. Scott Delaney, MD 5, Dr. Reza Ali- Hall Ambulatory Surgical Center, Joint Base San Antonio, San zadehfar, MD 1, Mr. Christopher Mill, BSc 3, Dr. Lawrence Joseph, Antonio, TX PhD3, Dr. Judy Morris, MD, MSc 6, Dr. Yuka Asai, MD 3,7 and Dr. 69 Epidemiology and Clinical Predictors Of Biphasic Reactions In Moshe Ben-Shoshan, MD, MSc1, 1Division of Paediatric Allergy Children With Anaphylaxis Waleed and Clinical Immunology, Department of Paediatrics, McGill Uni- D. Alqurashi 1, Ian Stiell 2, Kevin Chan 3, Gina Neto 1 and George versity Health Center, Montreal, QC, Canada, 2Division of Allergy Wells 4, 1Children’s Hospital of Eastern Ontario, Ottawa, ON, Can- and Clinical Immunology, Department of Medicine, McGill Univer- ada, 2Ottawa Hospital Research Institute, Ottawa, ON, Canada, sity Health Centre, Montreal, QC, Canada, 3Division of Clinical Ep- 3Hospital for Sick Children, Toronto, ON, Canada, 4University of idemiology, Department of Medicine, McGill University Health Ottawa Heart Institute, Ottawa, ON, Canada Centre, Montreal, QC, Canada, 4Food Directorate, Health Canada, 70 Age As a Risk Factor For Fatal Food-Induced Anaphylaxis: An Ottawa, ON, Canada, 5Department of Emergency Medicine, McGill Analysis Of UK and Australian Fatal Food Anaphylaxis Data University Health Center, Montreal, QC, Canada, 6Department of Dr. Paul J. Turner, FRACP PhD 1,2, Dr. Vibha Sharma, FRCPCH 3, Emergency Medicine, H opital^ du Sacr e-Cœur, Montreal, QC, Can- Prof. Mimi L. K. Tang, MD, PhD, FAAAAI 4, Ms. M. Hazel Gow- ada, 7Division of Dermatology, Department of Medicine, McGill land, BA 5, Dr. Nigel Harper, MBChB FRCA 3, Dr. Tomaz Garcez, University Health Centre, Montreal, QC, Canada MRCP FRCPath3, Dr. Richard Pumphrey, FRCPath 3 and Dr. Robert 77 Anaphylaxis Cases Presenting To Primary Care Paramedics In J. Boyle, MBChB PhD 1, 1Imperial College London, United King- Quebec dom, 2University of Sydney, Australia, 3Central Manchester Uni- Ms. Nofar Kimchi1, Dr. Ann Elaine Clarke, MD, MSc 2,3, Jocelyn versity Hospitals NHS Foundation Trust, United Kingdom, 4The Moisan4, Colette Lachaine 5, Dr. Sebastian La Vieille, MD 6, Dr. University of Melbourne, Melbourne, Australia, 5Allergy Action, Yuka Asai, MD 3,7, Dr. Lawrence Joseph, PhD 3,8, Mr. Christopher United Kingdom Mill, BSc3 and Dr. Moshe Ben-Shoshan, MD, MSc 9,10, 1Technion 71 Dying From Allergies: A Profile Of Fatal Anaphylaxis In The American Medical Students Program, Israel, 2McGill University United States: 1999-2010 Health Centre, Montreal, Canada, 3Division of Clinical Epidemiol- Dr. Elina Jerschow, MD, M.Sc. 1, Dr. Robert Yao-Wen Lin, ogy, Department of Medicine, McGill University Health Centre, FAAAAI 2,3, Ms. Moira Scaperotti, Medical Student 4 and Dr. Montreal, QC, Canada, 4Services pr ehospitaliers d’urgence de Aileen McGinn, PhD4, 1Albert Einstein College of Medicine/Mon- l’Outaouais, Quebec, Canada, QC, Canada, 5Direction adjointe tefiore Medical Center, Bronx, NY, 2New York Downtown Hospi- de services pr ehospitaliers d’urgence, MSSS, Quebec, Canada, tal, New York, NY, 3New York Medical College, Valhalla, NY, QC, Canada, 6Food Directorate, Health Canada, Ottawa, ON, Can- 4Albert Einstein College of Medicine, Bronx, NY ada, 7Division of Dermatology, Department of Medicine, McGill 72 Prospective Study To Determine Risk Factors and Severity Of University Health Centre, Montreal, QC, Canada, 8Departments Food-Induced Allergic Reactions In Children of Epidemiology and Biostatistics, McGill University, Montreal, Dr. Angela Tsuang, MD 1, Mr. Nikhil Menon, Medical student 1, Canada, 9Division of Paediatric Allergy and Clinical Immunology, Ms. Natasha Setia, Medical student1, Mr. Larry Geyman, Medical Department of Paediatrics, McGill University Health Center, Mon- student1, Ms. Christina Cherny 2 and Dr. Anna H. Nowak-Wegrzyn, treal, QC, Canada, 10 Montreal Children’s Hospital, Montreal, MD, FAAAAI 3, 1Mount Sinai School of Medicine, New York, NY, Canada

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78 Anaphylaxis Management In A Pediatric Emergency Depart- 86 Ten Years’ Experience Of Anaphylaxis In a Single University ment Hospital In Korea Natasha Sidhu, MD 1,2, Stacie M. Jones, MD 3,4, Elizabeth Storm, Dr. Cheol-Woo Kim , Inha University Hospital, Incheon, South Ko- MD 1,2, Maria Melguizo castro 1,5, Todd Nick 1,2 and Tonya Thomp- rea and Jae Hwa Cho, Inha University Hospital, South Korea son, MD 1,2, 1University of Arkansas for Medical Sciences, Little 87 Incidence Of Anaphylaxis In a Vilnius Lithuania Hospital Ap- Rock, AR, 2Arkansas Children’s Hospital, 3University of Arkansas plying WAO Criteria for Medical Sciences and Arkansas Children’s Hospital, Little Prof. Audra Blaziene 1, Dr. Neringa Buterleviciute 1, Viktorija Pal- Rock, AR, 4Arkansas Children’s Hospital Research Institute, Little tarackiene2 and Prof. Lawrence M. DuBuske, MD, FAAAAI 3, 1Vil- Rock, AR, 5Arkansas Children’s Hospital, Little Rock, AR nius University Medical School, Lithuania, 2Vilnius university 79 Characteristics Of Anaphylaxis In a Pediatric Emergency Unit Medical School, Lithuania, 3George Washington University School Beatriz Ameiro, M.D. 1, Blanca Noguerado, M.D. 1, Gabriela Zam- of Medicine, Washington, DC brano, M.D.1, Cristina Morales, M.D. 1, Miguel Guzm an, M.D.1, 88 Factors Associated With a Lower Probability Of Refilling An Marıa L. Baeza, MD, PhD 2 and Alberto Alvarez-Perea, MD 3, Epipen Auto-Injector In a Timely Manner 1Hospital General Universitario Gregorio Maran~on, Allergy De- Erin Buysman, MS 1, Dr. Ray A. Wolf, PharmD 2, Paul Cavanaugh, partmen, Madrid, Spain, 2Hospital General Universitario Gregorio Jr, PhD 3, Aylin Altan Riedel, PhD 1 and Tim Bancroft, PhD 1, 1OP- Maran~on, Allergy Department, Madrid, Spain, 3Hospital Materno TUM, Prairie Eden, MN, 2Mylan Specialty L.P., New Hope, PA, Infantil Gregorio Maran~on, Pediatric Allergy Department, Madrid, 3Mylan Specialty, Basking Ridge, NJ Spain 89 Food-Induced Anaphylaxis: Recognition and Response In Ohio 80 Characteristics Of Anaphylaxis and Angioedema In Pediatric Schools Emergency Center Dr. Erica Glancy, MD 1, Dr. Peter J. Mustillo, MD, FAAAAI 2, Dr. Dr. Jung Hyun Kwon , Departments of Pediatrics Ewha Womans Christine B. Cho, MD 3, Dr. Rekha Raveendran, MD 4 and Dr. Dan- University School of Medicine, Korea, Seoul, South Korea and iel Scherzer, MD 2, 1Cleveland Clinic, Cleveland, OH, 2Nationwide Dr. Hyun Sup Keum, Departments of Pediatrics Ewha Womans Children’s Hospital, Columbus, OH, 3National Jewish Health, Den- University School of Medicine, Korea, South Korea ver, CO, 4Asthma and Allergy Center LLC, Washington, DC 81 Anaphylaxis: Epidemiology and Treatment In The Emergency 90 Availability and Utilization Of Epinephrine In Utah Schools Department For The Management Of Anaphylaxis Dr. Judy Morris, MD, MSc 1,2 , Dr. Julie Lapointe 1, Dr. Sebastien Benjamin L. Wright, MD 1, Michelle Fogg, BS 2, Catherine La Vieille, MD 3, Dr. Harley Eisman, MD 4,5 , Dr. Reza Alizadeh- Sparks, MSN, RN, NCSN3, Brian P. Vickery, MD, FAAAAI 4, Dr. far, MD 6, Ms. Emma Perkins, BSc 7, Mr. Christopher Mill, BSc 7, Joseph L. Roberts, MD, PhD 5, Yamini Virkud, MD, MA 1 and Dr. Lawrence Joseph, PhD 5,7 , Dr. Ann Elaine Clarke, MD, MSc 7,8 Mandy Allison, MD, MSPH, M.Ed.6, 1Duke University, Durham, and Dr. Moshe Ben-Shoshan, MD, MSc 5,6 , 1Department of Emer- NC, 2Utah Food Allergy Network, Salt Lake City, UT, 3Utah De- gency Medicine, H opital^ du Sacr e-Cœur, Montreal, QC, Canada, partment of Health, Salt Lake City, UT, 4University of North Car- 2University of Montreal, Montreal, QC, Canada, 3Food Director- olina, Chapel Hill, NC, 5Duke University Medical Center, Durham, ate, Health Canada, Ottawa, ON, Canada, 4Montreal Children’s NC, 6University of Colorado Denver, Denver, CO Hospital, Montreal, QC, Canada, 5McGill University, Montreal, 91 Induction Of Remission Of Frequent Idiopathic Anaphylaxis QC, Canada, 6Division of Paediatric Allergy and Clinical Immu- With Rituximab nology, Department of Paediatrics, McGill University Health Dr. Arturo Borzutzky, MD , Division of Pediatrics, School of Med- Center, Montreal, QC, Canada, 7Division of Clinical Epidemiol- icine, Pontificia Universidad Catolica de Chile, Santiago, Chile, Dr. ogy, Department of Medicine, McGill University Health Centre, Pamela S. Morales, MD, Pediatric Rheumatology, Allergy and Im- Montreal, QC, Canada, 8Division of Allergy and Clinical Immu- munology Unit, Division of Pediatrics, School of Medicine, Pontifi- nology, Department of Medicine, McGill University Health Cen- cia Universidad Cat olica de Chile, Santiago, Chile, Dr. Veronica tre, Montreal, QC, Canada Mezzano, MD, Department of Rheumatology and 82 Anaphylaxis In An Upstate New York Emergency Department: Clinical Immunology, School of Medicine, Pontificia Universidad Triggers and Treatments Catolica de Chile, Santiago, Chile, Ms. Sofia Nussbaum, Dr. Britta Sundquist , Dr. Jaison Jose, Dr. John Paige, Keith Swee- Universidad de San Sebastian, Santiago, Chile and A. Wesley Burks, ney, Michael Lavelle, Dr. Daniel Pauze, Dr. Denis Pauze and Dr. MD, FAAAAI, University of North Carolina, Chapel Hill, NC Kirsi M. Jarvinen, Albany Medical College, Albany, NY 92 Evaluation Of a Diagnostic Protocol For Perioperative Anaphy- 83 The Clinical Characteristics Of Children and Adolescents With laxis Due To Isosulfan Blue Dye Allergy Anaphylaxis Who Visited 139 ERs In Korea In 2012 Ms. Mary Grace Baker, University of Virginia School of Medicine, Dr. Mi-Hee Lee , Department of Pediatrics, Seoul Women’s Hospi- Charlottesville, VA,Julia A. Cronin, MD, University of Virginia, Di- tal, Incheon, South Korea, Dr. Eun-Hee Chung, Department of Pe- vision of Asthma, Allergy and Immunology, Charlottesville, VA, Dr. diatrics,National Medical Center, Seoul, South Korea and Dr. Larry Borish, MD, FAAAAI, Asthma and Allergic Diseases Center, Young-Shil Lim, Division of Chronic Disease Surveillance, Korea Carter Center for Immunology Research, University of Virginia, Centers for Disease Control and Prevention, Osong, South Korea Charlottesville, VA and Dr. Monica G. Lawrence, MD, University 84 Pattern Of Epinephrine Use and Referral Of Emergency De- of Virginia Department of Medicine, Division of Asthma, Allergy partment Personnel In A Korean Hospital and Immunology, Charlottesville, VA Dr. Jae Won Jeong , Inje University Ilsan PAIK Hospital, Goyang- 93 Acute Serum Tryptase Elevation In ALTE - An Atypical Man- si, South Korea, Dr. Chansun PARK, Haeunda PAIK Hospital, ifestation Of Bullous Mastocytosis South Korea and Mi Young KIM, Busan PAIK Hospital, South Dr. Alexander Alvarez, MD , Virginia Commonwealth University, Korea Dr. Anne-Marie A. Irani, MD, FAAAAI, Virginia Commonwealth 85 Characterisation Of Anaphylaxis In a Large UK City With An University Health Systems, Richmond, VA and Dr. Lawrence B. Ethnically Diverse Population Schwartz, MD, PhD, FAAAAI, Virginia Commonwealth Univer- Richard J. Buka 1, Richard J. Crossman 2, Cathryn Derbridge 1, sity, Richmond, VA Aarnoud P. Huissoon 1, Scott Hackett 1, Matthew W. Cooke 1,2, Susan 94 Methodology For Identifying Patients Presenting With Anaphy- Dorrian1 and Mamidipudi T. Krishna 1, 1Birmingham Heartlands laxis Using Administrative Claims Data Hospital, Birmingham, United Kingdom, 2University of Warwick, Jerald Seare, MD 1, Erin Buysman, MS 1, Dr. Ray A. Wolf, United Kingdom PharmD2, Paul Cavanaugh, Jr, PhD 3, Aylin Altan Riedel, PhD 1

88 J ALLERGY CLIN IMMUNOL Abstracts AB299 VOLUME 133, NUMBER 2

and Tim Bancroft, PhD 1, 1OPTUM, Prairie Eden, MN, 2Mylan Spe- National Institutes of Health, Bethesda, MD, 2Unitat d’Al.lergia. Ser- cialty L.P., New Hope, PA, 3Mylan Specialty, Basking Ridge, NJ vei de Neumologia i Al.lergia Respiratoria. Hospital Clinic. Barce- 95 Epicare (Epinephrine Pen Investigation: Compliance and Rec- lona. Institut d’Investigacions Biom ediques August Pi i Sunyer ommendations) (IDIBAPS)., , Spain, 3Servei d’Immunologia, Centre de Di- Dr. Nisha S. Patel, MD , Thomas Jefferson University, Philadel- agnostic Biomedic. Hospital Clinic., Barcelona, Spain phia, PA, Dr. Christopher Chang, MD, PhD, FAAAAI, Alfred I du- 106 Recurrence Rates Of Anaphylaxis In Children Pont Hospital for Children, Wilmington, DE and Dr. Gang Ye, PhD, Dr. Andrew O’Keefe, MD 1,2, Dr. Yuka Asai, MD 3,4, Mr. Christo- Nemours, Orlando, FL pher Mill, BSc3, Dr. Harley Eisman, MD 5, Dr. Sebastian La Vieille, 96 Confusion With Substituting Epinephrine Auto-Injectors: A MD 6, Dr. Reza Alizadehfar, MD 5,7, Ms. Emma Perkins, BSc 3, Dr. Focus On Medication Counseling, Dispensing, and Patient Ed- Lawrence Joseph, PhD3, Dr. Ann Elaine Clarke, MD, MSc 3,8 and ucation Dr. Moshe Ben-Shoshan, MD, MSc 5,9, 1McGill University, Mon- Sonia Dhanjal, PharmD and Stacie Lampkin, PharmD, BCACP, treal, Canada, QC, Canada, 2Division of Pediatric Allergy and Clin-

AE-C, D’Youville College School of Pharmacy, Buffalo, NY ical Immunology, Montreal Children’s Hospital, Canada, 3Division SATURDAY 97 Omalizumab For a Case Of Monoclonal Mast Cell Activation of Clinical Epidemiology, Department of Medicine, McGill Univer- Syndrome With Recurrent Anaphylaxis sity Health Centre, Montreal, QC, Canada, 4Division of Dermatol- Dr. Amanda Jagdis , University of Toronto, Faculty of Medicine, ogy, Department of Medicine, McGill University Health Centre, Toronto, ON, Canada and Dr. Peter Vadas, MD, PhD, St. Michael’s Montreal, QC, Canada, 5McGill University, Montreal, QC, Canada, Hospital, Toronto, ON, Canada 6Food Directorate, Health Canada, Ottawa, ON, Canada, 7Division 98 Chlorhexidine Impregnated Central Venous Lines: A Poten- of Paediatric Allergy and Clinical Immunology, Department of Pae- tially Avoidable Cause Of Severe Perioperative Anaphylaxis diatrics, McGill University Health Center, Montreal, QC, Canada, Dr. Aisha Ahmed, MD and Dr. Katherine E. Gundling, MD, 8Montreal General Hospital, 9Montreal Children’s Hospital, Mon- UCSF, San Francisco, CA treal, Canada 99 Food Dependent Exercise Induced Anaphylaxis Treatment 107 Sensitization To Recombinant Allergens Of Hevea Brasilensis With Specific Oral Tolerance Induction Using IFN-Gamma In Patients With Latex Anaphylaxis Dr. Jae Ho Lee, MD, PhD , Department of Pediatrics, Chungnam Dr. J.M. Escobar Montalvo, MD 1, Ms. A. G omez Infante, MD 1, National University, Taejeon, South Korea, Dr. Sun Young Dr. Silvia Mart ınez Blanco, MD 2 and Dr. R. Vives Conesa, MD 1, You, MD, Department of Pediatrics, Taejeon, South Korea 1Hospital Universitario 12 de Octubre, Madrid, Spain, 2Hospital and Dr. Hye Young Han, MD, Department of Pediatrics, Universitario 12 de Octubre, Spain School of Medicine, Chungnam National University, Taejeon, 108 Patients Monosensitised To Hev b 8 Performs Surgery Without South Korea Avoidance The Latex and Without Complications 100 Food Associated Exercise Induced Anaphylaxis Associated Dr. Adriano Sa, MD , Federal University of S ~ao Paulo, S ~ao Paulo, With Late Phase Skin Test Reactivity To Shrimp Brazil, Dr. Leila Borges, MD, UNIFESP, Brazil, Dr. Nathalia Bar- Dr. Marisol Nardi , New York Downtown Hospital, New York and roso, Federal University of Sao Paulo, Dr. Luis Felipe C. Ensina, Dr. Robert Yao-Wen Lin, FAAAAI, New York Downtown Hospital, MD, Universidade Federal de S ~ao Paulo, S ~ao Paulo, Brazil, Ines New York, NY; Weill Cornell Medical College, New York, NY Nunes, Federal University of S ~ao P ~aulo and Prof. Dirceu Sole, 101 Idiopathic Capillary Leak Syndrome MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil Dr. Carl B. Lauter, MD, FAAAAI , William Beaumont Hospital 102 Comprehensive Metabolomic Analysis Identifies Uric Acid As a Critical Mediator Of Peanut Sensitization Mr. Joshua Kong 1, Dr. Kenneth Chalcraft, PhD 2, Dr. Rodrigo Ji- menez-Saiz, PhD1, Mrs. Tina Walker-Fattouh 2, Dr. Susanna Gon- HAE and Angioedema charova, MD, PhD 2, Dr. Brian McCarry, PhD 2 and Dr. Manel Jordana, MD, PhD1, 1McMaster Immunology Research Centre 2207 (MIRC), McMaster University, Hamilton, ON, Canada, 2McMaster Saturday, March 1st, 2014, 9:45 AM - 10:45 AM University, Hamilton, ON, Canada 109 Home Treatment With Conestat Alfa In Attacks Of Hereditary 103 Pharmacokinetics Of Berberine, a Bioactive Compound In Bu- Angioedema Due To C1-Inhibitor Deficiency tanol Purified Food Allergy Herbal Formula-2 Henriette Farkas, MD, PhD DSc 1, Dr. Erika Szabo 1, Dr. Dorottya Dr. Nan Yang, PhD, MS 1, Dr. Ying Song, MD 1, Dr. Changda Liu, Csuka, PhD2, Dr. Kinga, Vikt oria Kohalmi 1, Dr. Zsuzsanna Zotter 1 PhD1, Sool Yeon Cho, PhD 2 and Dr. Xiu-Min Li, MD 1, 1Pediatrics, and Dr. Lilian Varga, PhD 1, 1Semmelweis University, Budapest, Icahn School of Medicine at Mount Sinai, New York, NY, 2Hema- Hungary, 2Hungarian HAE Center, 3rd Department of Internal tology, Icahn School of Medicine at Mount Sinai, New York Medicine, Semmelweis University, Budapest, Hungary City, NY 110 Comparison Of Plasma Kallikrein Inhibition By The Monoclo- 104 Anaphylaxis After Bitten By Domestic Hamster: A Case Report nal Antibody Inhibitor DX-2930 To Endogenous C1-INH Dr. Leila Borges, MD 1, Dr. Danielle Bichueti Silva, MD 2, Dr. Tessa Daniel Sexton, Jon Kenniston, Ryan Faucette, Andrew Nixon, Rachel Tranquilini Gonc¸alves, MD 3, Dr. Rafael Rota, MD 3, Camila Christopher TenHoor, Yung H. Chyung and Burt Adelman, Dyax Gonzaga da Silva 4, Dr. Danieli Hirari, MD 4, Dr. Marcia Mallozi, Corp. MD 5 and Prof. Dirceu Sole, MD, PhD3, 1UNIFESP, Brazil, 2Univer- 111 The Prophylactic Use Of C1 Esterase Inhibitor (Berinert Ò) In sidade Federal de S ~ao Paulo, S ~ao Paulo, Brazil, 3Federal University HAE Patients Undergoing Invasive Procedures of Sao Paulo, Sao Paulo, Brazil, 4Federal University of S ~ao Paulo, Rachel Harrison, BSc 1, Stephanie Santucci, RN 1, Genevieve Gav- S~ao Paulo, Brazil, 5Federal University of S ~ao Paulo, Brazil igan, MASc, MD 2 and William H. Yang, MD 1,2, 1Allergy and 105 Gene Expression Profiling Of Food-Induced Anaphylaxis Asso- Asthma Research Corp., Ottawa, ON, Canada, 2University of Ot- ciated With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) tawa Medical School, Ottawa, ON, Canada Dr. Rosa M. Munoz-Cano, MD, PhD 1,2 , Dr. Joan Bartra, MD, PhD 2, 112 Self-Administration Of a Novel Subcutaneous Bradykinin B2 Re- Dr. Jorg Scheffel, PhD 1, Dr. Mariona Pascal, PhD 3, Dr. Barbara Dema, ceptor Antagonist, Icatibant (Firazyr Ò), As An Effective Treat- PhD 1, Dr. Antonio Valero, MD, PhD 2, Dr. Ana Olivera, PhD 1, Prof. ment Option In Patients With Hereditary Angioedema (HAE) Cesar Picado, MD, PhD 2 and Dr. Juan , PhD 1, 1National Insti- Stephanie Santucci, RN 1, Hoang Pham, MD 2016, BSc, BA 2, Ra- tute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), chel Harrison, BSc1 and William H. Yang, MD 1,2, 1Allergy and

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Asthma Research Corp., Ottawa, ON, Canada, 2University of Ottawa Vesna Grivcheva- Panovska, MD, PhD 13 , Dr. Marcel Levi, MD 14 , Medical School, Ottawa, ON, Canada Dr. Hilary Longhurst, MD 15 , Dr. Alejandro Malbran, MD 16 , Dr. 113 Current Medical Management Of Hereditary Angioedema Dumitru Moldovan, MD, PhD17 , Dr. Gregor Porebski, MD 18 , Dr. (HAE): Follow-Up To a Large Survey Of US Physicians Avner Reshef, MD 19 , Dr. Petra Staubach, MD 20 , Dr. Andrea Zani- Dr. Marc A. Riedl, MD, MS , University of California, San Diego, chelli, MD 21 , Dr. Yu-xiang Zhi, MD 22 and Dr. Teresa Caballero, La Jolla, CA, Dr. Richard G. Gower, MD, FAAAAI, Marycliff Al- MD, PhD4,23, 1Hospital Universitario Severo Ochoa, Madrid, lergy Specialists, Spokane, WA and Dr. Aleena Banerji, MD, Divi- Spain, 2Psychology Faculty, Universidad Autonoma, Madrid, sion of Rheumatology, Allergy, and Immunology, Department of Spain, 3Hospital Universitario Fundacion Alcorc on, Madrid, Spain, Medicine, Massachusetts General Hospital, Harvard Medical 4Allergy Department, Hospital La Paz Institute for Health Research School, Boston, MA (IdiPaz), Madrid, Spain, 5Research Unit, Hospital La Paz Institute 114 HAE In a Southern Louisiana Kindred: Novel Gene Mutations for Health Research (IdiPaz), Madrid, Spain, 6Department of Der- Dr. Adrian Casillas, MD, FAAAAI , Baylor College of Medicine, matology and Venereology, Medical University of , Graz, Aus- Houston, TX tria, 7Institute of Pneumology and Allergy. San Fernando’s 115 Hereditary Angioedema Without C1 Inhibitor Deficiency: Ob- Hospital, Panama City, Panama, 8University of Toronto, Division servation Of Patients Homozygous For FXII GENE Mutation of Clinical Immunology and Allergy, Toronto, ON, Canada, 9Na- Christiane Stieber1, Camila Veronez 2, Nathalia Cagini 2, Elisabete tional Reference Centre for Angioedema, Internal Medicine De- Cordeiro3, Dr. Anete S. Grumach 3, Rosemeire Constantino-Silva 3, partment, Grenoble University Hospital, Grenoble, , Joao Bosco Pesquero2 and Sven Cichon4, 1Life & Brain Center 10 Denmark HAE Centre, Department of Dermatology and Allergy and Institute of Human Genetics, University of Bonn, Germany, Centre, Odense University Hospital, Odense, Denmark, 11 Hungar- 2Federal University of S ~ao Paulo, Brazil, 3Faculty of Medicine ian HAE Center, 3rd Department of Internal Medicine, Semmel- ABC, Brazil, 4Division of , Department of Bio- weis University, Budapest, Hungary, 12 Department of medicine, University of Basel, Dermatology, School of Medicine, University of Sao Paulo, Sao 116 Hereditary Angioedema Without C1 Inhibitor Deficiency: Clin- Paulo, Brazil, 13 Unit of Allergology and Clinical Immunology. De- ical Evaluation Of 67 Brazilian Patients partment of Dermatology. Medicine School University Sts Cyril Elisabete Cordeiro1, Camila Veronez 2, Christiane Stieber 3, Natha- and Methodius, Skopje, Macedonia, 14 Department of Internal Med- lia Cagini2, Rosemeire Constantino-Silva 1, Rozana Gonc¸alves 4, icine,Academic Medical Center,University of Amsterdam., Amster- Gustavo Fusaro 4, Neusa Wandalsen 1, Sven Cichon 5, Joao Bosco dam, Netherlands, 15 Barts Health NHS Trust, London, United Pesquero2 and Dr. Anete S. Grumach 1, 1Faculty of Medicine Kingdom, 16 British Hospital of Buenos Aires, Buenos Aires, Ar- ABC, Brazil, 2Federal University of S ~ao Paulo, Brazil, 3Life & gentina, 17 Department of Allergology–Immunology, Mures County Brain Center and Institute of Human Genetics, University of Hospital, Tirgu-Mures, Romania, 18 Department of Clinical and En- Bonn, Germany, 4Federal University of Minas Gerais, Brazil, 5Di- vironmental Allergology, ,, Krakow, Poland, vision of Medical Genetics, Department of Biomedicine, University 19 Allergy, Clinical Immunology & Angioedema Unit, Chaim Sheba of Basel, Switzerland Medical Center, Tel Hashomer, Israel, 20 Department of Dermatol- 117 Circulating Extracellular Micrornas In Hereditary Angioe- ogy, University Medical Center, University of Mainz, Mainz, Ger- dema many, 21 Internal Medicine Department, Luigi Sacco Hospital, Peisong Gao, MD, PhD 1, Kenneth Witwer, PhD 2, Melissa McA- Milan, Italy, 22 Peking Union Medical College Hospital, Beijing, lexander 2, Priya Tripathi, PhD 1, Tamara Johnson 3 and Dr. Huamin China, 23 Biomedical Research Network on Rare Diseases (CI- Henry Li, MD, PhD, FAAAAI 3, 1Division of Allergy & Clinical BERER, U754), Madrid, Spain Immunology, Johns Hopkins University School of Medicine, 122 Relationship Between Angioedema Attacks and Health-Related Baltimore, MD, 2Johns Hopkins Institute for NanoBioTechnol- Quality Of Life Outcomes In Patients With Hereditary Angio- ogy, Baltimore, MD, 3Institute for Asthma and Allergy, Chevy (HAE) Chase, MD Dr. Jeff Dayno, MD 1, Dave P. Miller 2, Ms. Emily Hautamaki, 118 Hereditary Angioedema In The Pediatric Patient MPH3, Scott Newcomer 1, David Fitts 1 and Dr. William R. Lumry, Dr. Gregory H. Bennett, DO , Penn State Children’s Hospital, Her- MD, FAAAAI 4,5, 1ViroPharma Incorporated, 2ICON Clinical Re- shey, PA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State Uni- search, 3Oxford Outcomes, an ICON plc company, 4AARA Re- versity College of Medicine, Hershey, PA search Center, Dallas, TX, 5Allergy and Asthma Specialists, 119 Clinical Features Of Pediatric Hereditary Angioedema Dallas, TX Shelby N. Elenburg, MD 1, Amal H. Assa’ad, MD, FAAAAI 2, Dr. 123 Health-Related Quality Of Life (HRQoL) In Adult Patients Jonathan A. Bernstein, MD, FAAAAI 3 and Maya Nanda, MD 2, With Hereditary Angioedema Due To C1 Inhibitor Deficiency 1University of Tennessee Health Science Center, Memphis, TN, (HAE-C1-INH) Assessed By SF-36v2 2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, Dr. Teresa Caballero, MD, PhD 1,2 , Dr. Magdalena Julia Cami- 3Division of Immunology Allergy & Rheumatology, University of noa, MD 1, Elia P erez-Fern andez, MSc 3, Dr. Carmen G omez-Tra- Cincinnati Medical Center, Cincinnati, OH seira, MD 1, Dr. Anne Aabom, MD 4, Prof. Werner Aberer, MD 5, 120 A Case Series Of Seven Pediatric Patients Successfully Treated Dr. Stephen D. Betschel, MD 6, Prof. Anette Bygum, MD 4, Dr. With Ecallantide and Icatibant For Hereditary Angioedema Dorottya Csuka, PhD 7, Henriette Farkas, MD, PhD DSc 7, Dr. Ma- Heather Minto, MD 1,2 and Kelly M. Maples, MD 1,2, 1Eastern Vir- ria Gomide, MD 8, Dr. Adriane Groffik, MD 9, Dr. Anete S. Grum- ginia Medical School, Norfolk, VA, 2Children’s Hospital of The ach 8, Mrs. Iris Leivobich 10 , Dr. Alejandro Malbran, MD 11 , Dr. King’s Daughters, Norfolk, VA Eniko Mihaly, MD 12 , Dr. Dumitru Moldovan, MD, PhD 13 , Dr. 121 IHAE-Qol: Specific Health-Related Quality Of Life (HRQoL) Krystyna Obtulowicz, MD 14 , Dr. Gregor Porebski, MD 15 , Mrs. Questionnaire In Hereditary Angioedema Due To C1 Inhibitor Celina Rayonne 16 , Dr. Avner Reshef, MD 10 , Dr. Petra Staubach, Deficiency (HAE-C1INH) MD 9, Dr. Michaela Wiednig, MD 5, Maria Joao Forjaz 17,18 and Dr. Nieves Prior, MD 1, Prof. Eduardo Remor 2, Elia P erez-Fernan- Dr. Nieves Prior, MD 19 , 1Allergy Department, Hospital La Paz In- dez, MSc3, Dr. Carmen G omez-Traseira, MD 4, Dr. Magdalena Julia stitute for Health Research (IdiPaz), Madrid, Spain, 2Biomedical Caminoa, MD 4, Francisco Gay a5, Prof. Werner Aberer, MD 6, Dr. Research Network on Rare Diseases (CIBERER, U754), Madrid, Olga Melcina Barrera, MD 7, Dr. Stephen D. Betschel, MD 8, Spain, 3Hospital Universitario Fundaci on Alcorc on, Madrid, Prof. Laurence Bouillet, MD, PhD9, Prof. Anette Bygum, MD 10 , Spain, 4Denmark HAE Centre, Department of Dermatology and Henriette Farkas, MD, PhD DSc11 , Dr. Anete S. Grumach 12 , Dr. Allergy Centre, Odense University Hospital, Odense, Denmark,

90 J ALLERGY CLIN IMMUNOL Abstracts AB301 VOLUME 133, NUMBER 2

5Department of Dermatology and Venereology, Medical Univer- Milan, Italy, 8Allergy Department, Hospital La Paz Institute for sity of Graz, Graz, , 6University of Toronto, Division of Health Research (IdiPaz), Madrid, Spain Clinical Immunology and Allergy, Toronto, ON, Canada, 7Hun- 127 Most Hereditary Angioedema (HAE) Attacks Resolved After garian HAE Center, 3rd Department of Internal Medicine, Sem- One Icatibant Injection: Analysis Of FAST-3 Open-Label Ex- melweis University, Budapest, Hungary, 8Department of tension Study Dermatology, School of Medicine, University of Sao Paulo, Sao Dr. William R. Lumry, MD, FAAAAI , Allergy and Asthma Spe- Paulo, Brazil, 9Department of Dermatology, University Medical cialists, Dallas, TX, Jovanna Baptista, MS, Shire, Lexington, MA, Center, University of Mainz, Mainz, Germany, 10 Allergy, Clinical Dr. Marc A. Riedl, MD, MS, University of California, San Diego, Immunology & Angioedema Unit, Chaim Sheba Medical Center, La Jolla, CA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State Tel Hashomer, Israel, 11 British Hospital of Buenos Aires, Buenos University College of Medicine, Hershey, PA Aires, Argentina, 12 Department of Allergology–Immunology, 128 Evaluation Of Icatibant Reinjection Of Laryngeal Hereditary Mures County Hospital, T ırgu-Mures, Romania, 13 Department Angioedema Attacks: A Pooled Analysis Of Three Phase III

of Allergology–Immunology, Mures County Hospital, Tirgu- Open-Label Extension Studies SATURDAY Mures, Romania, Tirgu-Mures, Romania, 14 Department of Clini- Jovanna Baptista, MS , Shire, Lexington, MA, Dr. Jonathan A. cal and Enviromental Medicine, Jagiellonian University, Krakow, Bernstein, MD, FAAAAI, Division of Immunology Allergy & Poland, 15 Department of Clinical and Environmental Allergology, Rheumatology, University of Cincinnati Medical Center, Cincin- Jagiellonian University, Krakow, Poland, 16 ReSolve Research So- nati, OH, Dr. William R. Lumry, MD, FAAAAI, Allergy and lutions Inc., Whitby, Ontario, Canada, 17 National School of Pub- Asthma Specialists, Dallas, TX and Dr. Marc A. Riedl, MD, MS, lic Health, Carlos III Institute of Public Health, Madrid, Spain, University of California, San Diego, La Jolla, CA 18 REDISSEC, Madrid, Spain, 19 Hospital Universitario Severo 129 Successful and Safe Use Of Icatibant For Life-Threatening An- Ochoa, Madrid, Spain gioedema Attack During Pregnancy In a Patient With Heredi- 124 The Icatibant Outcome Survey: Characteristics Of Patients tary Angioedema Type I With Hereditary Angioedema Requiring Reinjection Dr. Karine Boufleur, MD 1, Ms. Luana Delcaro 1, Dr. Daniel L. Dr. Hilary Longhurst, MD , Barts Health NHS Trust, London, Cordeiro, MD 1, Dr. Priscila B. Botelho Palhas, MD 1, Dr. Janaina United Kingdom, Prof. Marcus Maurer, MD, Department of Der- Fernandes de Melo Sousa, MD 1, Dr. Tha ıs Mendonc¸a, MD 1, Dr. Ja- matology and Allergy, Charit e – Universit €atsmedizin, Berlin, Ger- naina Michele de Lima Melo, MD 1, Dr. Gustavo Neppelenbroek, many, Dr. Vincent Fabien, PhD, Shire, Eysins, Switzerland, Prof. MD 1, Prof. Wlly Sarti 1, Dr. Adriana S. Moreno, PhD 1 and Dr. Luisa Werner Aberer, MD, Department of Dermatology and Venereology, Karla P. Arruda, MD, PhD, FAAAAI 2, 1Ribeirao Preto Medical Medical University of Graz, Graz, Austria, Prof. Laurence Bouillet, School, University of Sao Paulo, Ribeirao Preto, Brazil, 2School MD, PhD, National Reference Centre for Angioedema, Internal of Medicine of Ribeirao Preto, Ribeirao Preto, Brazil Medicine Department, Grenoble University Hospital, Grenoble, 130 Recombinant Human C1 Inhibitor Treatment Does Not Affect France, Dr. Andrea Zanichelli, MD, Dipartimento di Scienze Bio- D-Dimer Levels and Is Not Associated With Thromboembolic mediche e Cliniche, Ospedale Luigi Sacco, Universit a degli Studi Events In HAE Patients di Milano, Milan, Italy and Dr. Teresa Caballero, MD, PhD, Allergy Dr. Avner Reshef, MD , Allergy, Clinical Immunology & Angioe- Department, Hospital La Paz Institute for Health Research (IdiPaz), dema Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dr. Madrid, Spain Andrea Zanichelli, MD, Dipartimento di Scienze Biomediche e 125 The Icatibant Outcome Survey: Characterizing Breakthrough Cliniche, Ospedale Luigi Sacco, Universit a degli Studi di Milano, Hereditary Angioedema Attacks In Patients Receiving Long- Milan, Italy, Dr. Hilary Longhurst, MD, Barts Health NHS Trust, Term Prophylaxis London, United Kingdom, Yun Hardiman, MS, Santarus Inc., San Prof. Werner Aberer, MD , Department of Dermatology and Vene- Diego, CA, Anurag Relan, MD, Pharming Technologies BV, Lei- reology, Medical University of Graz, Graz, Austria, Prof. Marcus den, Netherlands and C. Erik Hack, MD, University Medical Center Maurer, MD, Department of Dermatology and Allergy, Charit e – Utrecht, Utrecht, Netherlands Universit €atsmedizin, Berlin, Germany, Prof. Laurence Bouillet, 131 C1-Esterase Inhibitor Concentrate For Acute Attacks Of La- MD, PhD, National Reference Centre for Angioedema, Internal ryngeal Edema In Hereditary Angioedema (HAE): Fixed Dos- Medicine Department, Grenoble University Hospital, Grenoble, ing Vs Body Weight-Adjusted Dosing France, Amandine Perrin, Shire, Eysins, Switzerland, Dr. Andrea Konrad Bork, MD 1, Dr. Jonathan A. Bernstein, MD, FAAAAI 2, Zanichelli, MD, Dipartimento di Scienze Biomediche e Cliniche, Henrike Feuersenger3, Thomas Machnig 3 and Dr. Timothy J. Craig, Ospedale Luigi Sacco, Universit a degli Studi di Milano, Milan, DO, FAAAAI 4, 1University of Mainz, Mainz, Germany, 2Division Italy, Dr. Teresa Caballero, MD, PhD, Allergy Department, Hospi- of Immunology Allergy & Rheumatology, University of Cincinnati tal La Paz Institute for Health Research (IdiPaz), Madrid, Spain and Medical Center, Cincinnati, OH, 3CSL Behring GmbH, Marburg, Dr. Hilary Longhurst, MD, Barts Health NHS Trust, London, Germany, 4Penn State University College of Medicine, Hershey, PA United Kingdom 132 Sustained Response Following Acute Treatment Of Hereditary 126 The Icatibant Outcome Survey: Rate and Impact Of Treatment Angioedema Attacks With Recombinant Human C1 Esterase By Self-Administration Inhibitor Dr. Dolores Hern andez Fern andez de Rojas, MD 1, Dr. Ethel H.Henry Li, MD, PhD, Institute for Asthma and Allergy, Chevy Ib anez,~ MD 1, Dr. Hilary Longhurst, MD 2, Prof. Marcus Maurer, Chase, MD, Dr. Marc A. Riedl, MD, MS, University of California, MD 3, Dr. Vincent Fabien, PhD 4, Prof. Werner Aberer, MD 5, Prof. San Diego, La Jolla, CA, Dr. Jonathan A. Bernstein, MD, FAAAAI, Laurence Bouillet, MD, PhD6, Dr. Andrea Zanichelli, MD 7 and Division of Immunology Allergy & Rheumatology, University of Dr. Teresa Caballero, MD, PhD 8, 1IIS Hospital Universitario La Cincinnati Medical Center, Cincinnati, OH, Dr. William R. Lumry, Fe, Valencia, Spain, 2Barts Health NHS Trust, London, United MD, FAAAAI, AARA Research Center, Dallas, TX, Dr. Avner Re- Kingdom, 3Department of Dermatology and Allergy, Charit e – Uni- shef, MD, Allergy, Clinical Immunology & Angioedema Unit, versit€atsmedizin, Berlin, Germany, 4Shire, Eysins, Switzerland, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dr. Dumitru 5Department of Dermatology and Venereology, Medical University Moldovan, MD, PhD, Department of Allergology–Immunology, of Graz, Graz, Austria, 6National Reference Centre for Angioe- Mures County Hospital, Tirgu-Mures, Romania, Tirgu-Mures, Ro- dema, Internal Medicine Department, Grenoble University Hospi- mania, Henriette Farkas, MD, PhD DSc, Semmelweis University, tal, Grenoble, France, 7Dipartimento di Scienze Biomediche e Budapest, Hungary, Dr. Gregor Porebski, MD, Department of Clin- Cliniche, Ospedale Luigi Sacco, Universit a degli Studi di Milano, ical and Environmental Allergology, Jagiellonian University,

91 AB302 Abstracts J ALLERGY CLIN IMMUNOL

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Krakow, Poland, Marcin Stobiecki, MD, Jagiellonian University 1BioCryst Pharmaceuticals, Inc, Birmingham, AL, 2BioCryst Phar- College, Krakow, Poland, Yun Hardiman, MS, Santarus Inc., San maceuticals, Durham, NC Diego, CA, Anurag Relan, MD, Pharming Technologies BV, Lei- 144 Incidence and Treatment Of Angioedema In a Third Level den, Netherlands and Prof. Marco Cicardi, MD, PhD, Department Spanish Hospital of Internal Medicine, Luigi Sacco Hospital, Milan, Italy, Milan, Marta Seoane, MD , Maria Elisa Caralli, MD, Sarah Micozzi, MD, Italy Marta Elena Rodriguez-Mazariego, MD and Mar ıa L. Baeza, MD, 133 Efficacy Of C1Inhibitor Concentrate (Berinert) For Severe An- PhD, Hospital General Universitario Gregorio Mara n~on, Allergy gioedema Attacks Induced By Drugs Targeting The Renin-An- Department, Madrid, Spain giotensin Aldosterone System 145 Seasonal Increase In Angioedema In An Inner City Hospital Prof. Laurence Bouillet , Grenoble university hospital, Grenoble, Center France, Dr. Bernard Floccard, Lyon university hospital, Lyon, Helen Zhou, BS , Dr. Ashlei Mathew, MD and Dr. Rauno Joks, MD, France, Dr. Isabelle Boccon-Gibod, Grenoble University Hospital, Center for Allergy and Asthma Research, State University of New Grenoble, France, Dr. Sebastien Trouiller, Centre hospitalierd York Downstate Medical Center, Brooklyn, NY ’Aurillac, Aurillac, France, Dr. Anne Du-Than, Montpellier univer- 146 Seeming Tongue Swelling Responding To Nebulized Ipratro- sity hospital, Montpellier, France and Prof. Olivier Fain, Jean Ver- pium In An Individual With A Diagnosis Of Type III HAE (He- dier universty hospital, Bondy, France reditary Angioedema) 134 Professional Administration Costs In The US For On-Demand Ms. Jennifer Vegh 1, Dr. Arthur B. Vegh, MD, FAAAAI 2 and Ms. Therapy Of Hereditary Angioedema Nicholette Butler1, 1none, Tacoma, WA, 2University of Washington, Thomas Machnig, CSL Behring GmbH, Marburg, Germany and Tacoma, WA Mr. Art Zbrozek, RPh, MSc, MBA, CSL Behring LLC, King of 147 Cytokine Expression In a Case Of Cutaneous Mastocytosis Prussia, PA With An Unusual Presentation 135 Successful Administration Of C1Esterase Inhibitor (C1inh) In Prof. Young Min Ahn, MD , Department of Pediatrics, South Ko- An Individual Anaphylactic To It rea, Prof. sang-Hoon Kim, Department of Internal Medicine, South Dr. Arthur B. Vegh, MD, FAAAAI 1, Ms. Marni Sellers 2, Ms. Korea, Prof. Ho-jung Lee, Department of Pathology,Eulji Univer- Nancy Boyden 2 and Ms. Jennifer Vegh 2, 1University of Washing- sity School of Medicine, South Korea and Prof. Jai Youl Ro, ton, Tacoma, WA, 2none, Tacoma, WA PhD, Sungkyunkwan University School of Medicine, South 136 Evaluation Of DX-88 (Ecallantide) For Treatment Of Angioten- Korea sin Enzyme Inhibitor Induced Angioedema In The Emergency Department Dr. Joseph Moellman, MD 1, Dr. Jonathan A. Bernstein, MD, FAAAAI 2, Ms. Kimberly Hart 1, Dr. Sean Collins 3 and Dr. Christo- pher Lindsell1, 1University of Cincinnati, Cincinnati, OH, 2Division of Immunology Allergy & Rheumatology, University of Cincinnati Population, Health in Asthma Medical Center, Cincinnati, OH, 3Vanderbilt University, Nashville, TN 2208 137 Ecallantide In Treatment Of Type III Hereditary Angioedema Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Dr. Anil Nanda, MD , Asthma and Allergy Center, Lewisville, TX; 148 Aerochambers and Asthmatics: Do No Harm? UT Southwestern Medical Center, Dallas, TX and Dr. Anita N. Wa- Dr. Jack Leon-Max Mutnick, MD , Stevens Community Medical san, MD, Allergy and Asthma Center, Lansdowne, VA Center, Morris, MN 138 BCX4161, An Oral Kallikrein Inhibitor: Safety and Pharmaco- 149 Characterizing The Severe Asthma Population In The United kinetic Results Of a Phase 1 Study In Healthy Volunteers States: Claims-Based Analysis Of Three Treatment Cohorts Dr. Phil Collis 1, Dr. Melanie Cornpropst 1, Dr. Jo Collier 2 and Dr. In The Year Prior To Treatment Escalation William Sheridan 1, 1BioCryst Pharmaceuticals, Durham, NC, Dr. Patrick W. Sullivan, PhD 1, Dr. Jon Campbell, PhD 2, Dr. Vah- 2Quotient Clinical, Nottingham, United Kingdom ram Ghushchyan, PhD2, Dr. Gary Globe, PhD 3, Dr. Jeff , 139 Treatment Of Hereditary Angioedema At The Time Of Prodro- PhD3 and Dr. J Michael Woolley, PhD 3, 1Regis University, 2Univer- mal Symptoms: International Survey Of Physicians sity of Colorado Denver, 3Amgen, Inc., Thousand Oaks, CA Dr. Neelu Kalra, MD , Penn State Hershey Medical Center, Her- 150 Impact Of Asthma On Child and Family Activities Among a shey, PA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State Uni- Rural Cohort versity College of Medicine, Hershey, PA Dr. Allison J. Burbank 1,2, Mallikarjuna Rettiganti, PhD 1,2, Paige 141 Structural and Molecular Changes Caused By Mutations Fisher, BA 3 and Tamara T. Perry, MD 1,2, 1University of Arkansas Thr328Lys and Thr328Arg In FXII Associated With Hereditary for Medical Sciences, Little Rock, AR, 2Arkansas Children’s Hos- Angioedema With Normal C1 Inhibitor pital, Little Rock, AR, 3Drexel University School of Public Health, Dr. Adriana S. Moreno, PhD , Ribeirao Preto Medical School, Philadelphia, PA University of Sao Paulo, Ribeirao Preto, Brazil, Dr. Helen Arcuri, 151 Inhaled Asthma Medications: Highlighting The Differences In PhD, Institute of Investigation in Immunology iii, School of Medi- Formulations and Use cine of the University of Sao Paulo, S ~ao Paulo, Brazil, Prof. Mario Dr. Lachara Lvingston Livingston , University of South Florida Palma, PhD, Biosciences Institute, State University of S ~ao Paulo, Morsoni College of Medicine, Dr. Gregory Michael Cowan, MD, Rio Claro, Brazil and Dr. Luisa Karla P. Arruda, MD, PhD, University of South Florida Morsani College of Medicine and Dr. FAAAAI, School of Medicine of Ribeirao Preto, Ribeirao Preto, Richard F. Lockey, MD, Division of Allergy and Immunology, De- Brazil partment of Internal Medicine, University of South Florida Morsani 142 Ludwig’s Angina Masquerading As Angioedema College of Medicine and James A. Haley Veterans’ Affairs Hospi- Dr. Lynn A. Wiens, MD, FAAAAI , Warren Clinic, Tulsa, OK tal, Tampa, FL 143 A Simple, Sensitive and Selective Fluorogenic Assay To Monitor 152 Rhinitis and Asthma Exacerbation Revealing Large Pulmonary Plasma Kallikrein Inhibitory Activity Of BCX4161 In Activated Effusion and Pelvic Mass Plasma Dr. Jennifer Olivier, MD , Tulane University School of Medicine, Dr. YS Babu 1, Ms. Ramanda Wilson 1, Dr. Jianwen Zhang 1, Dr. New Orleans, LA and Dr. Laurianne G. Wild, MD, FAAAAI, Tu- Melanie Cornpropst2, Dr. Phil Collis 2 and Dr. William Sheridan 2, lane University, New Orleans, LA

92 J ALLERGY CLIN IMMUNOL Abstracts AB303 VOLUME 133, NUMBER 2

153 Deprivation Is Longitudinally Associated With Incident Child- Diagnostics hood Asthma Dr. Elinor Simons, MD, MS, FAAAAI 1,2, Dr. Sharon Dell, MD 2,3, 4,5 1,5 1 2210 Dr. Rahim Moineddin, PhD and Dr. Teresa To, PhD , Child Saturday, March 1st, 2014, 9:45 AM - 10:45 AM Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada, 2Clinical Epidemiology, Department of Health Policy, 160 Phadiatop - An Atopy Test With Optimal Allergen Composition Relevant For Most Geographical Regions Management and Evaluation, University of Toronto, Toronto, ON, 1 1 2 3 Kerstin M. Wall , Monica Nor en and Dr. Cathy Van Rooyen , Canada, Respiratory Medicine and Child Health Evaluative Sci- 1 4 Thermo Fisher Scientific, ImmunoDiagnostics, Uppsala, Sweden, ences, Hospital for Sick Children, Toronto, ON, Canada, Depart- 2 ment of Family and Community Medicine, University of Toronto, Ampath National Reference Laboratory, Immunology, Pretoria, Toronto, ON, Canada, 5Institute for Clinical Evaluative Sciences, South Africa Toronto, ON, Canada 161 Histamine Skin Reactivity Increased With Body Mass Index In

154 Use Of Asthma Control Indicators In Measuring Efficacy Of In- Korean Children SATURDAY haled Corticosteroids In Asthmatic Smokers: A Systematic Re- Dr. Jeon Mi Lee , Dr. Ju Wan Kang and Dr. Hyung Ju Cho, Yonsei view University College of Medicine Ms. Claire E. Hayes, MPH, CHES, AE-C and Mr. Henry Nuss, 162 The Impact Of Component Resolved Diagnosis On Allergen- PhD, Louisiana State University Health Sciences Center School Specific Immunotherapy Prescription In Children With Pol- of Public Health, New Orleans, LA len-Related Allergic Rhinitis Dr. Paolo Matricardi, MD 1, Dr. Giovanna Stringari 2, Prof. Carlo 155 Evaluation Of a Medication Adherence Estimator Survey Com- 2 3 4 pared To Exhaled Nitric Oxide (FeNO) Levels and Asthma Con- Caffarelli , Dr. Riccardo Asero, MD , Dr. Arianna Dondi , Dr. Sal- vatore Tripodi 5 and The Italian Pediatric Allergy Network 6, trol Test In Difficult-To-Treat/Severe Pediatric Asthma Patients 1 2 1 2 2 Charite, Berlin, Germany, Pediatric Department, University of Jigar Patel , Vanessa Y. Cavero, MD , Amy Perkins, MS , 3 2 2 Parma, Parma, Italy, Clinica San Carlo, Paderno Dugnano, Italy, Heather Minto, MD and Maripaz B. Morales, MD , 4 1 Department of Pediatrics, University of Bologna, Bologna, Italy, Department of Pediatrics, Eastern Virginia Medical School, 5 6 Norfolk, VA, 2Children’s Hospital of The King’s Daughters, Pediatric Department, Ospedale Sandro Pertini, Roma, Italy, . Norfolk, VA 163 Randomized Evaluation Of Ten Allergy Skin Prick Test Devices Dr. Yohalakshmi Chelladurai, MD, MPH 1, Prof. Robert G. Ham- ilton, PhD D.ABMLI FAAAAI 2 and Dr. Jody R. Tversky, MD 2, 1Johns Hopkins University Bloomberg School of Public Health, 2Johns Hopkins University School of Medicine, Baltimore, MD Healthcare Delivery in Primary 164 Phenotypic Classification Of Allergen Polysensitization In Ger- iatric Adults Immunodeficiency Dr. Rohit Divekar, MBBS, PhD 1, Dr. John B. Hagan, MD, FAAAAI 2 and Hirohito Kita, MD 2, 1Division of Allergic Diseases, 2209 Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 165 Analysis Of The Discordance Between Immunocap and Skin 156 An Assessment Of Infection Rates and Health Resource Use Prick Test For Common Allergens In Patients With Allergic Among Primary Immunodeficiency Disorder (PIDD) Patients Rhinitis Symptoms Prior To Diagnosis Dr. Do Yang Park 1, Prof. Hyun Jun Kim 1, Dr. Ju Wan Kang 2, Prof. Dr. Chris Rabbat, PhD , Ms. Diane Ito, MA, Ms. Yan Xiong, MS Yoo Suk Kim 1 and Prof. Chang-Hoon Kim 3, 1Ajou University and Dr. Josephine Li-McLeod, PhD, Baxter Healthcare Corpora- School of Medicine, 2Yonsei University College of Medicine, 3De- tion, Westlake Village, CA partment of , Yonsei University College of 157 A Comparison Of Costs Between Outpatient Hospital, Clinic and Medicine, Seoul, South Korea Home Settings For Intravenous Immunoglobulin (IVIG) Infusions 166 Role Of House Dust Mites In Allergic and Non Allergic Nasal Dr. Xiaolan Ye,PhD , Ms. Diane Ito, MA, Ms. YanXiong, MS and Dr. Diseases Josephine Li-McLeod, PhD, Baxter Healthcare Corporation, Westlake Prof. Maged Refaat, MD 1, Prof. Tarek Mansour 1, Prof. Talaat Village, CA Samny 2, Prof. Ahmed Zaki 3, Prof. Eman Osman 1, Dr. Eman Ez- 158 Differences In Infection Rates Between Outpatient Hospital, zat 1 and Dr. Eman Ahmed 1, 1Department of Allergy and Clinic and Home Infusion Settings For Patients With Primary Clinical immunology,Ain Shams university, Cairo, Egypt, 2De- Immunodeficiency Disorder (PIDD) partment of ear,nose and throat diseases,Ain Shams university, Ms. Diane Ito, MA , Ms. Yan Xiong, MS, Dr. Xiaolan Ye, PhD and Cairo, Egypt, 3Department of pathology,Ain Shams university, Dr. Josephine Li-McLeod, PhD, Baxter Healthcare Corporation, Cairo, Egypt Westlake Village, CA 167 Immunogenicity and IgE Blocking Capacity Of a Mixture Of 159 Assessment Of The Quality Of Life and Health Resource Utili- Depigmented and Chemically Modified Allergens From Differ- zation Burden Among Patients With Primary Immunodefi- ent Homologous Groups ciency Disorder (PIDD) Prior To Treatment Dr. Victor Miguel Iraola , Mr. Jos e Ram on Leonor, Dr. Mar ıa Mo- Dr. John M. Routes, MD, FAAAAI 1, Dr. Beatriz Tavares Costa- rales, Dr. Raquel Moya, Dr. M. Angeles L opez Matas, Dr. M a Ter- Carvalho, MD 2, Prof. Bodo Grimbacher, MD 3, Dr. Kenneth Paris, esa Gallego and Dr. Jer onimo Carnes, Laboratorios LETI, Tres MD, MPH 4, Dr. Hans D. Ochs, MD 5, Ms. Diane Ito, MA 6, Ms. Cantos, Spain Yan Xiong, MS 6, Dr. Josephine Li-McLeod, PhD 6 and Dr. Ri- 168 Modified Shuffled Blo t 5 Recombinant Allergen From Blomia chard I. Schiff, MD, PhD 7, 1Medical College of Wisconsin, Mil- Tropicalis Produces a Shift Of Antigenicity For Binding To waukee, WI, 2Federal University of Sao Paulo, Brazil, 3Royal IgG4 Isotype 1  1 Free Hospital & University College, London, United Kingdom, Dr. Ernesto Taketomi, MD, PhD , Mrs. B arbara Avila, MSc , 4LSU Health Sciences Center, New Orleans, New Orleans, LA, Mrs. Karine Almeida, PhD1, Mrs. Deise Silva, PhD 1, Prof. Odon ırio 5University of Washington, Seattle, WA, 6Baxter Healthcare Cor- Abrah~ao J unior, PhD 2 and Prof. Jair Cunha-Junior, PhD 1, 1Federal poration, Westlake Village, CA, 7Baxter BioScience, Westlake University of Uberl ^andia, Uberlandia, Brazil, 2Federal University of Village, CA Triangulo Mineiro, Uberaba, Brazil

93 AB304 Abstracts J ALLERGY CLIN IMMUNOL

SATURDAY FEBRUARY 2014

Oral Immunotherapy Fernandez-Rivas, MD, PhD 5 and Javier Mart ınez-Botas, PhD1,6, 1Hospital Universitario Ramon y Cajal. Instituto Ram on y Cajal  2 2211 para la Investigaci on Sanitaria, Madrid, Spain, Hospital del Sure- 3  Saturday, March 1st, 2014, 9:45 AM - 10:45 AM ste, Arganda del Rey, Spain, Hospital Cl ınico San Carlos, Spain, 4Hospital Universitario 12 de Octubre, Spain, 5Hospital Cl ınico 169 Induction Of Arah2-Specific Memory B Cells Identified Using a San Carlos, Madrid, Spain, 6CIBER de Fisiopatolog ıa de la Obesi- Novel Tetramer-Based Approach Occurs Early and Transiently dad y Nutrici on (CIBEROBN), Instituto de Salud Carlos III, Ma- During Peanut Oral Immunotherapy drid, Spain Dr. Sarita U. Patil, MD 1,2, Dr. Adebola Ogunniyi, PhD 3, Mr. Alex Ma 4, Ms. Alisa K. Brennan, B.S. 5, Ms. Theadora Swenson, BA 6, Mr. Agustin Calatroni, MA MS 7, Dr. James Moon, PhD 8, Dr. J.Christopher Love, PhD 3 and Wayne G. Shreffler, MD, PhD, Mechanisms of Cytokines and Chemokines FAAAAI 1,6, 1Harvard Medical School, Boston, MA, 2Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 3Mas- 2212 sachusetts Institute of Technology, Cambridge, MA, 4Massachusetts Saturday, March 1st, 2014, 9:45 AM - 10:45 AM General Hospital, Charlestown, MA, 5Rush Medical College, Chi- 176 IL-33 and TSLP Mediate Chronic Eosinophilic Airway Inflam- cago, IL, 6Massachusetts General Hospital, Boston, MA, 7Rho, mation and IgE Antibody Production Induced by Multiple Air- Inc., Chapel Hill, NC, 8Harvard Medical School, Charlestown, MA borne Allergens 170 De Novo Generation Of Gastrointestinal Regulatory T Cells In Koji Iijima, PhD 1, Takao Kobayashi, PhD 1, Kenichiro Hara, Response To OIT and EPIT MD 1,2, Gail Kephart 1 and Hirohito Kita, MD 1, 1Mayo Clinic, Ro- Leticia Tordesillas, PhD 1, Lucie Mondoulet, PhD 2, Pierre Henri chester, MN, 2Gunma University Graduate School of Medicine, Benhamou, MD 2, Hugh A. Sampson, MD, FAAAAI 3 and M. Ceci- Maebashi, Gunma, Japan lia Berin, PhD1, 1Icahn School of Medicine at Mount Sinai, New 177 IL-17 Enhances TNF-a-Induced, But Not IL-1b-Induced, Ex- York, NY, 2DBV Technologies, Bagneux, France, 3Pediatrics, Icahn pression Of Neutrophil-Associated Cytokines By Human Lung School of Medicine at Mount Sinai, New York, NY Tissue Cells 171 Long Term Protection Against New Sensitization After Milk- Dr. Akio Matsuda, PhD , Dr. Kenichiro Motomura, MD, Dr. Tetsuo Epit In Mice Sensitized To Milk Is Mediated By Tregs Shoda, MD, Dr. Kyoko Futamura, MD, PhD, Dr. Hirohisa Saito, Pierre Henri Benhamou, MD 1, Dr. Vincent Dioszeghy, PhD 1, MD., PhD. and Dr. Kenji Matsumoto, MD, PhD, Department of Al- Mrs. Emilie Puteaux1, Mrs. M elanie Ligouis1, Mrs. V eronique lergy and Immunology, National Research Institute for Child Dhelft1, Mrs. Camille Plaquet 1, Prof. Christophe Dupont, MD, Health and Development, Tokyo, Japan PhD2 and Lucie Mondoulet, PhD1, 1DBV Technologies, Bagneux, 178 Prostaglandin I Receptor (IP) Signaling Inhibits Alternaria-In- France, 2Hopital Necker Enfants Malades, Paris, France 2 duced IL-5 and IL-13 Expression Through Group 2 Innate 172 Epicutaneous Immunotherapy-Induced Regulatory T Cells Lymphoid Cells (ILC2) Could Migrate To More Various Sites Of Allergen Exposure Dr. Shinji Toki, PhD , Kasia Goleniewska, Sara Reiss, MS, Dr. Compared To Sublingual Or Subcutaneous Immunotherapy Weisong Zhou, PhD and Dr. R. Stokes Peebles Jr., MD, FAAAAI, In Mice Sensitized To Peanut Vanderbilt University School of Medicine, Nashville, TN Dr. Vincent Dioszeghy, PhD 1, Lucie Mondoulet, PhD 1, Mrs. 179 Local Administration Of CCL28 Is Sufficient To Drive Airway Veronique Dhelft1, Mrs. M elanie Ligouis1, Mrs. Emilie Puteaux 1, Hyper-Responsiveness and Mucous Cell Metaplasia Mrs. Camille Plaquet1, Prof. Christophe Dupont, MD, PhD 2 and Dr.Becky Buelow, MD , Mrs. Desire Hunter and Dr. Mitchell H. Gray- Pierre Henri Benhamou, MD 1, 1DBV Technologies, Bagneux, son, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI France, 2Hopital Necker Enfants Malades, Paris, France 180 Mucosal Uric Acid Induces Interleukin 33 and Initiates Type 2 173 Anaphylactic Reactions After Peanut Oral Immunotherapy Immune Responses To Inhaled Protease Allergens Noam Berlin1, Dr. Amanda Jagdis 1, Carly Barron 2, Sean Macla- Kenichiro Hara, MD 1, Koji Iijima, PhD 2, Takao Kobayashi, PhD 2, chlan3, Mohana Giruparajah 2, Nathan Leader 4, Dennis Penn 5 and Dr. Satoshi Seno 3, Dr. Ichiro Tojima 3, Gail Kephart 2, Dr. Manabu Dr. Gordon L. Sussman, FAAAAI 1, 1University of Toronto, Faculty Ueno1, Dr. Toshitaka Maeno 1, Dr. Masahiko Kurabayashi 1 and Hir- of Medicine, Toronto, ON, Canada, 2Gordon Sussman Clinical Re- ohito Kita, MD 2, 1Gunma University Graduate School of Medicine, search Inc., Toronto, ON, Canada, 3University of Ottawa, Faculty of Maebashi, Gunma, Japan, 2Mayo Clinic, Rochester, MN, 3Shiga Medicine, Ottawa, ON, Canada, 4University of Melbourne, Faculty University of Medical Science, Otsu, Shiga, Japan of Medicine, Melbourne, Australia, 5MastCell Pharmaceuticals, 181 Surrogate Biomarkers Of Eosinophilic Airway Inflammation In Inc., Raleigh, NC Asthma: Quantitation Of Major Basic Protein-1 and Charcot- 174 Evaluation Of The Immunological Mechanisms Involved In The Leyden Crystal Protein/Galectin-10 In Induced Sputum Efficacy Of Sublingual Immunotherapy With Ltp (Pru p 3) In Dr. Sharmilee M. Nyenhuis, MD, FAAAAI 1,2, Mr. Preeth Alum- Allergic Patients Sensitized To Food By Ltps kal, BS 3, Dr. Jian Du, MD 3, Brian Maybruck, PhD 3, Mr. Mark Vin- Dr. Francisca Gomez, MD, PhD 1, Dr. Enrique Gomez, MD, PhD 2, icky, BS 3, Ms. Melissa Morales-Perez, BS 3, Dr. Jerry A. Krishnan, Dr. Maria J Torres, MD, PhD 3, Mrs. Luisa Galindo, RN 3, Ms. Maria MD, PhD4 and Dr. Steven J. Ackerman, PhD 3, 1Jesse Brown VA Dolores Ruiz3, Dr. Inmaculada Do na,~ MD, PhD3, Mrs. Gador Bo- Medical Center, Chicago, IL, 2MC 719, University of Illinois at gas1, Dr. Paloma Campo, MD, PhD 3, Dr. Teresa Posadas 3, Dr. Mi- Chicago, Chicago, IL, 3University of Illinois at Chicago, Chicago, guel Blanca, MD, PhD3 and Dr. Cristobalina Mayorga, PhD 4, IL, 4University of Illinois at Chicag, Chicago, IL 1Allergy Service, Carlos Haya Hospital, Spain, 2Research Labora- 182 IL-35-Producing T Cells (iTR35) Inhibit Th2 Effector Function, tory, Carlos Haya Hospital-FIMABIS, Spain, 3Allergy Service, Car- Induce Infectious Tolerance and Are Elevated Following Grass los Haya Hospital, Malaga, Spain, 4Research Laboratory, Carlos Pollen Sublingual Immunotherapy Haya Hospital-FIMABIS, Malaga, Spain Dr. Mohamed H. Shamji, BSc MSc PhD 1, Ms. Janice Layhadi, 175 Changes In IgE and IgG4 Epitopes After Milk Oral Immuno- BSc( Hons)2, Mr. Alan Perera-web, BSc( Hons) 2,3, Ms. Rachel therapy (OIT) Yan, RN 4 and Prof. Stephen R. Durham, MA MD FRCP 5, 1Imperial Belen de la Hoz Caballer, MD, PhD 1, Mrs. Cristina Vlaicu 1, In- College London, South Kensington, United Kingdom, 2Imperial maculada Cerecedo Carballo, MD, PhD2, M onica Rodrıguez- College London, 3Medical Research Council and Asthma UK Cen- Alvarez, MD 3, Dr. Maria Carmen Di eguez Pastor, MD 4, Montserrat

94 J ALLERGY CLIN IMMUNOL Abstracts AB305 VOLUME 133, NUMBER 2

tre for Allergic Mechanisms of Asthma, UK, 4Imperial College 192 Differential Promoter Usage and Regulation Of The Human In- London, United Kingdom, 5Imperial College London, London, terleukin-5 Receptor a (IL-5Ra) Gene In Developing Eosino- United Kingdom phil Progenitors 183 Th2 Cytokines Inhibit Toll-Like Receptor 2 Mediated Epider- Kimberly G. Laffey, BSc , Dr. Jian Du, MD and Dr. Steven J. Ac- mal Barrier Repair kerman, PhD, University of Illinois at Chicago, Chicago, IL Takeshi Yoshida, PhD 1, I-Hsin Kuo, PhD 1, Anna De Benedetto, 193 Multiplex Cytokine Analysis Of Cord Blood Non-Adherent MD, FAAAAI 1, Donald Y.M. Leung, MD, PhD, FAAAAI 2 and Mononuclear Cells From Infants With Attributable Atopic Lisa A. Beck, MD, FAAAAI 1, 1University of Rochester Medical Risk Following Il-5 Stimulation Center, Rochester, NY, 2National Jewish Health, Denver, CO Mrs. Jenny Thiele, MSc , Queens University, Kingston, ON, Can- 184 Epicutaneous Sensitization To Food Allergens Induce IL-4-Pro- ada, Ms. Vanessa N. Omana, MSc, Queen’s University, ON, Canada ducing Cells and T Follicular Helper (Tfh) Cells In An IL-6 and and Dr. Anne K. Ellis, MD, MSc FAAAAI, Allergy Research Unit, IL-1-Dependent Manner Kingston General Hospital, Kingston, ON, Canada; Departments of

Ritobrata Goswami, PhD, Leticia Tordesillas, PhD and M. Cecilia Medicine and Biomedical & Molecular Science, Queen’s Univer- SATURDAY Berin, PhD, Icahn School of Medicine at Mount Sinai, New York,NY sity, Kingston, ON, Canada 185 Enhanced Thymic Stromal Lymphopoietin-Induced Eosinophil- 194 Association Of IL-33 With Atherogenic Cytokines: A Link Be- Basophil Lineage Commitment In Atopic Individuals tween Allergic Disease and Atherosclerosis Claudia C.K. Hui, MSc1, Sina Rusta-Sallehy, BSc 1, Dr. Ilan Dr. Misu Paul, MD 1, Dr. Allison B. Reiss, MD 2, Dr. Steven Carsons, Asher, MD 1, Delia Heroux, BSC 1 and Judah Aryeh Denburg, MD 3, Dr. Luz S. Fonacier, MD, FAAAAI 4 and Dr. Iryna Voloshyna, MD, FRCPC, FAAAAI 2, 1McMaster University, Hamilton, ON, PhD 2, 1Section of Allergy and Clinical Immunology, Department of Canada, 2Division of Clinical Immunology and Allergy, Depart- Medicine, Winthrop University Hospital, mineola, NY, 2Winthrop Re- ment of Medicine, McMaster University, ON, Canada search Institute, Department of Medicine, Winthrop University Hospi- 186 CMRF35-Like Molecule 1 (CLM-1) Is Required For IL-33-In- tal, Mineola, NY, 3Division of Rheumatology, Allergy and duced Eosinophil Activation Immunology, Department of Medicine, Winthrop University Hospital, Dr. Ariel Munitz, PhD 1, Mrs. Dana Shik 1, Mr. Itay Moshkovits 2 Mineola, NY, 4Section of Allergy and Clinical Immunology, Depart- and Mrs. Danielle Karo-Atar1, 1Department of Clinical Microbiol- ment of Medicine, Winthrop University Hospital, Mineola, NY ogy and Immunology, The Sackler School of Medicine, Tel-Aviv 195 Modulation Of Human Basophil Degranulation By Geranylger- University, Tel Aviv, Israel, 2Tel-Aviv University, Israel anyl Compounds 187 Role Of Interleukine-33 In Rhinovirus-Induced Allergic Dr. Yuko Nakase 1, Dr. Masao Yamaguchi 1, Dr. Naoya Sugimoto 1, Asthma Exacerbation Dr. Maho Suzukawa, MD 2, Dr. Hiroyuki Tamiya 1, Dr. Yasuhiro Ko- Dr. Marie Toussaint, DMV, PhD , Dr. Aran Singanayagam, MD, jima1, Dr. Hisanao Yoshihara 1, Dr. Michio Kuramochi 1, Dr. Hide- Prof. Sebastian L. Johnston, MD, PhD and Dr. Nathan Bartlett, nori Arai1, Dr. Hiroyuki Nagase 1 and Dr. Ken Ohta 1,2, 1Teikyo PhD, Imperial College London, London, United Kingdom University School of Medicine, Tokyo, Japan, 2National Hospital 188 TGF-beta1 Mobilizes Mesenchymal Stem Cells In Allergic Organization Tokyo National Hospital, Tokyo, Japan Asthma 196 Variation In mRNA Expresion Of GATA1 and PRG2 In Umbil- Ting Xu, MD 1,2, Ling-Ling Xian, MD, PhD 3, Yufeng Zhou, MD, ical Cord Blood Following IL-5 Stimulation PhD1, Beverly Plunkett, MS 1, Xu Cao, PhD 3, Mei Wan, MD, Ms. Vanessa N. Omana, MSc , Queen’s University, ON, Canada, PhD3 and Peisong Gao, MD, PhD1, 1Division of Allergy & Clinical Mrs. Jenny Thiele, MSc, Queens University, Kingston, ON, Canada Immunology, Johns Hopkins University School of Medicine, Balti- and Dr. Anne K. Ellis, MD, MSc FAAAAI, Departments of Medi- more, MD, 2Department of Respiratory Medicine, Southern Medi- cine and Biomedical & Molecular Science, Queen’s University, cal University, Guangzhou, China, 3Department of Orthopedics Kingston, ON, Canada Surgery, Johns Hopkins University School of Medicine, Baltimore, 197 Mast Cells Drive Tissue Inflammation By Producing IL-33 That MD Orchestrates a Unique Basophil Phenotype 189 IL-10-Producing B Cells Are Increased After Grass Pollen Im- Dr. Chia-Lin Hsu, PhD and Dr. Paul Bryce, PhD, Division of Al- munotherapy Compared To Untreated Grass Pollen Allergic lergy-Immunology, Department of Medicine, Feinberg School of Controls: A Blinded Cross-Sectional Study Medicine, Northwestern University, Chicago, IL Mr. James E G Charlesworth 1,2 , Dr. Guy W Scadding, MD 1,2 , Dr. 198 Differential Regulation Of Pro-Inflammatory Cytokine Expres- Aarif Eifan, MD 2, Ms. Rachel Yan, RN 2, Ms. Andrea Goldstone, sion Of Airway Smooth Muscle Cells (ASM) By Insulin, Glu- RN 2, Dr. Moises A. Calderon, MD, PhD 1,2 , Prof. Stephen R. Durham, cose, and Rosiglitazone MA MD FRCP 3,4 and Dr. Mohamed H. Shamji, BSc MSc PhD 5, Dr. Qura-Tul-Ain Rashid, MD , Allergy and Immunology, Univer- 1Medical Research Council and Asthma UK Centre for Allergic Mech- sity of Texas Medical Branch, Dr. Lata Kaphalia, PhD, University anisms of Asthma, United Kingdom, 2Imperial College London, of Texas Medical Branch, Galveston and Dr. William J. Calhoun, United Kingdom, 3Imperial College London, London, United King- MD, FAAAAI, Allergy And Immunology, University of Texas dom, 4Medical Research Council and Asthma UK Centre for Allergic Medical Branch, Galveston, TX Mechanisms of Asthma, London, United Kingdom, 5Imperial College London, South Kensington, United Kingdom 190 Respiratory Syncytial Virus Induces IL-25 and IL-33 Produc- tion In The Lungs Role of Granulocytes and Mast Cells in Matthew T. Stier 1, Kasia Goleniewska 2 and R. Stokes Peebles 1,2, 1Department of Pathology, Microbiology, and Immunology, Van- Mechanisms of Allergic Disease derbilt University School of Medicine, Nashville, TN, 2Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, 2213 Vanderbilt University School of Medicine, Nashville, TN Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 191 Small-Molecule Inhibition Of Stat3 Prevents House-Dust-Mite 199 An Association Between Disease Severity and Levels Of Low- (HDM)-Induced Airway Inflammation By Blocking Lung Pro- Density Granulocytes In The Peripheral Blood Mononuclear duction Of Th17 and Th2 Cytokines Cell Fraction Of Asthma Subjects Dr. Aries C. Gavino, MD and Dr. David J. Tweardy, MD, Baylor Dr. Mary C. Tobin, M.D. 1,2, Dr. Jun Fu, PhD 1, Ms. Paige Adeli, College of Medicine, Houston, TX RN 1 and Dr. Larry L. Thomas, PhD 1, 1Rush University Medical

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Center, Chicago, IL, 2University Consultants in Asthma and Al- 209 Regulation Of Reactive Oxygen Species Production Involving lergy, Chicago, IL Src Family Kinase In Siglec-8 Induced Eosinophil Cell Death 200 Asthma Severity and Expression Of CLC3 On Human Periph- Dr. Gen Kano, MD, PhD , Kyoto Prefectural University of Medi- eral Blood and Nasal Lavage Eosinophils cine, Kyoto, Japan, Bruce S. Bochner, MD, FAAAAI, Division of Devendra K. Agrawal , Rohit Gaurav and Againdra K. Bewtra, De- Allergy and Clinical Immunology, Northwestern University School partments of Biomedical Sciences and Internal Medicine, and Cen- of Medicine, Chicago, IL and Dr. Nives Zimmermann, MD, ter for Clinical and Translational Science, Creighton University FAAAAI, Children’s Hospital Medical Center, Cincinnati, OH School of Medicine, Omaha, NE 210 Ragweed Pollen Extract (RWPE)-Induces TLR4-Dependent 201 The Interaction Of Bifidobacteria With Human Blood Leuko- Neutrophil Recruitment That Augments Allergic Airway In- cytes flammation Dr. Leonid P. Titov, MD, PhD 1, Dr. A.S. Murashko 2, Dr. Andrei Dr. Koa Hosoki, MD, PhD , Dr. Leopoldo Aguilera-Aguirre, PhD, Y. Hancharou 3, Dr. N.A. Golovnyova 3, Dr. E.I. Kolomiets 3 and Prof. Istvan Boldogh, PhD, Dr. Qian Sun, PhD and Prof. Sanjiv Sur, Prof. Lawrence M. DuBuske, MD, FAAAAI 4, 1Republican Scien- MD, University of Texas Medical Branch, Galveston, TX tific and Practical Center for Epidemiology and Microbiology, 211 LAMP1 and CD63 Expression In Mouse Mast Cells and Human Minsk, Belarus, 2Republican Scientific And Practical Center for Basophils Rendered Hyporesponsive By Antigen/IgE-Mediated Epidemiology and Microbiology, Minsk, Belarus, 3Republican Sci- Activation and Desensitization entific and Practical Center for Epidemiology and Microbiology,- Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI 1, Dr. Matthieu Minsk, Belarus, 4George Washington University School of Picard, MD 2, Dr. Joana Caiado, MD 2, Dr. Veronica Mezzano, MD 2 Medicine, DC and Dr. Mariana C. Castells, MD, PhD, FAAAAI 2, 1Clinical Imun- 202 Worldwide Impact Of LAD2 Mast Cell Line On Mast Cell Bi- nology and Allergy Division, University of Sao Paulo, Boston, MA, ology Research 2Division of Rheumatology, Allergy and Immunology, Department Arnold S. Kirshenbaum, MD, FAAAAI 1, Amy Petrik, PhD 2, of Medicine, Brigham and Women’s Hospital, Harvard Medical Rosemary Walsh, PhD 2, Sury Vepa, PhD JD 3 and Dean D. Met- School, Boston, MA calfe, MD, FAAAAI 1, 1Laboratory of Allergic Diseases, NIAID, 212 Vectorial Exposure and Fusion Of Secretory Granule Content NIH, Bethesda, MD, 2Technology Transfer and Intellectual Prop- At The Mast Cell Degranulatory Synapse erty Office, NIAID, NIH, Bethesda, MD, 3Office of Technology Dr. Nicolas Gaudenzio 1, Mr. Regis Joulia 2, Prof. Salvatore Vali- Transfer, NIH, Rockville, MD tutti2 and Dr. Eric Espinosa 2, 1Stanford University, Stanford, CA, 203 Non c-Kit Tyrosine Kinase Expression In Mast Cell 2INSERM U1043, Toulouse, France Dr. Joseph H. Butterfield, MD, FAAAAI , Mayo Clinic, Roches- 213 Airway Tissue, But Not Luminal, Eosinophilia Is Related To ter, MN The Magnitude Of Airway Hyperresponsiveness In a Trans- 204 Characterization Of Systemic Mastocytosis Patients Based genic Murine Model Of Cat Allergy Solely On The Minor Criteria Mr. Daniel M. Moldaver 1, Dr. Mantej S. Bharhani 1, Ms. Jennifer Dr. Anupama Ravi, MD and Dr. Joseph H. Butterfield, MD, Wattie 1, Ms. Tarandeep Singh 1, Ms. Melissa Babra 1, Dr. Marianne FAAAAI, Mayo Clinic, Rochester, MN van Hage, MD 2, Dr. Mark D. Inman, MD, PhD 1 and Dr. Mark 205 Basophil Activation Is a Reliable Biomarker Of Allergic Bron- Larche, PhD 1, 1McMaster University, Hamilton, ON, Canada, 2Kar- chopulmonary Aspergillosis (ABPA) In CF: One Year Results olinska Institutet, Department of Medicina Solna, Clinical Immu- Of a Longitudinal Cohort Study nology and Allergy Unit, Stockholm, Sweden Dr. Yael Gernez, MD, PhD 1,2, Mr. Jeffrey 2, Mrs. Colleen 214 IgE–Mediated Mast Cell Responses Are Inhibited By Thymol- Dunn2, Zoe Davies 2, Dr. Rabindra Tirouvanziam 3, Mrs. Cassie Mediated Activation-Induced Cell Death Everson2, Dr. John Tamaresis 2, Prof. Leonore Herzenberg 4 and Dr. Joshua B. Wechsler, MD 1, Dr. Chia-Lin Hsu, PhD 2 and Dr. Dr. Richard B. Moss, MD 5, 1Highland Hospital, San Francisco, Paul Bryce, PhD2, 1Ann & Robert H. Lurie Children’s Hospital 2Stanford University School of Medicine, Stanford, CA, 3Emory of Chicago, Chicago, IL, 2Division of Allergy-Immunology, De- University School of Medicine, Department of Pediatrics, Atlanta, partment of Medicine, Feinberg School of Medicine, Northwestern GA, 4stanford, School of Medicine, stanford, 5Stanford University University, Chicago, IL School of Medicine, Palo Alto, CA 215 Mechanisms Of Non-IgE-Mediated Uptake Of Antigen By Hu- 206 Exosomes Secretion By Eosinophils: A Possible Role In Asthma man Mast Cells Pathogenesis Dr. Brant Ward, MD, PhD , Ms. Sahar Lotfi-Emran and Dr. Law- Victoria Del Pozo, PhD 1, Carla Mazzeo 1, Ainara Rodriguez rence B. Schwartz, MD, PhD, FAAAAI, Virginia Commonwealth Marco2, Mar Del Mar fERNANDEZ-NIETO 3, Maria Paz Zafra 4, University, Richmond, VA Veronica Sanz 1 and Prof. Joaquin Sastre, MD, PhD, FAAAAI 3, 216 Human EMR1, An Eosinophil-Specific Surface Receptor Of 1IIS-FJD and CIBERES, 2IIS-FJD, 3Fundacion Jimenez Diaz, Ma- Unknown Function, Is Modulated In Vivo and In Vitro drid, Spain, 4IIS-Fundacion Jim enez Dıaz Dr. Fanny Legrand 1, Dr. Nenad Tomasevic 2, Mrs. Michelle Ma- 207 CD49d-Expressing Neutrophils Are Found In The Nasal Lavage kiya1, Dr. Christopher Bebbington 2 and Dr. Amy D. Klion, MD 1, During An Acute Upper Respiratory Illness 1National Institutes of Health, Bethesda, MD, 2Allakos Dr. Jerome Sigua, MD , Dr. Mitchell H. Grayson, MD, FAAAAI, 217 Cyclo-Oxygenase Inhibition Increases The Frequency Of Dr. Pippa Simpson, PhD, Ms. Erika Buell, Mrs. Desire Hunter CD49d+ Neutrophils In The Bronchoalveolar Lavage (BAL) and Dr. Dorothy S. Cheung, MD, FAAAAI, Medical College of During a Respiratory Viral Infection Wisconsin, Milwaukee, WI Ms. Jennifer A. Hass , Ms. Erika Buell, Mrs. Desire Hunter, Dr. 208 Estradiol Has a Negative Impact On The Anaphylactic Re- Dorothy S. Cheung, MD, FAAAAI and Dr. Mitchell H. Grayson, sponse In Mice, Independent From Mast Cell Degranulation MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI Valerie Hox, MD, PhD 1,2, Avanti Desai 1, Geethani Bandara, PhD 1, 218 High Blood Eosinophils Predict Reductions In Sputum Mast Alasdair M. Gilfillan, PhD 1, Dr. Michael Beaven, PhD 3, Dr. Ana Cells and Lung Function In Response To Triamcinolone In Olivera, PhD 1 and Dean D. Metcalfe, MD, FAAAAI 1, 1Laboratory Asthma of Allergic Diseases, NIAID, NIH, Bethesda, MD, 2Laboratory of Dr. Merritt L. Fajt, MD 1, Ms. Crystal Uvalle, BS 1, Mr. John Tru- Clinical Immunology, Department of Microbiology and Immunol- deau, BA 1 and Sally E. Wenzel, MD, FAAAAI 2, 1The University of ogy, KULeuven, Leuven, Belgium, 3Laboratory of Molecular Im- Pittsburgh Asthma Institute at UPMC and the University of Pitts- munology, NHLBI, NIH, Bethesda, MD burgh School of Medicine, Department of Pulmonary, Allergy

96 J ALLERGY CLIN IMMUNOL Abstracts AB307 VOLUME 133, NUMBER 2

and Critical Care Medicine, 2The University of Pittsburgh Asthma Hospital of Chicago, Chicago, IL; Division of Allergy & Immunol- Institute at UPMC and the University of Pittsburgh School of Med- ogy, Department of Pediatrics, Northwestern University Feinberg icine, Department of Pulmonary, Allergy and Critical Care Medi- School of Medicine, Chicago, IL cine, Pittsburgh, PA 227 Epinephrine Use In Positive Oral Food Challenges Performed 219 Analyses Of IL-33-Producing Cells During Multiple Antigen As Screening For Food Allergy Therapeutic Trials Challenges In Murine Asthma Ms. Sally A. Noone, RN MSN CCRC 1, Jaime Ross, RN 2, Hugh A. Dr.Takeshi Nabe 1, Mr. Hiroki Wakamori 1, Ms. Anna Takiguchi 1, Mrs. Sampson, MD, FAAAAI 3 and Dr. Julie Wang, MD, FAAAAI 2, Haruka Kida 1, Prof. Susumu Ohya 1, Dr. Nobuaki Mizutani 2, Prof. Shin 1Icahn School of Medicine at Mount Sinai, New York, NY, 2The Yoshino 2 and Prof. David Chaplin 3, 1Kyoto Pharmaceutical University, Icahn School of Medicine at Mount Sinai, New York, NY, 3Pediat- Kyoto, Japan, 2Kobe Pharmaceutical University, Kobe, Japan, 3Univer- rics, Icahn School of Medicine at Mount Sinai, New York, NY sity of Alabama at Birmingham, Birmingham, AL 228 School Experience With Food Allergy Reactions Highlight The 220 Repeat Lipopolysaccharide Exposure Is Sufficient To Impair Need For Training and Availability Of Epinephrine

Viral Induced Pro-Atopic, CD49d Expressing Neutrophil Re- Mrs. Katherine A. Schmeissing, MS, R.N. 1, Christine Szychlin- SATURDAY cruitment To The Lung ski, APN, CPNP2, Dr. Jacqueline Pongracic, MD, FAAAAI 1,3 and Dr. Wei An, MD 1,2, Ms. Jennifer A. Hass 2, Ms. Erika Buell 2, Mrs. Dr. Anne Marie Singh, MD 4, 1Ann & Robert H. Lurie Children’s Desire Hunter2, Dr. Dorothy S. Cheung, MD, FAAAAI 2 and Dr. Hospital of Chicago, Chicago, IL, 2Division of Allergy & Immunol- Mitchell H. Grayson, MD, FAAAAI 2, 1Froedtert Hospital, Milwau- ogy, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chi- kee, WI, 2Medical College of Wisconsin, Milwaukee, WI cago, IL, 3Division of Allergy & Immunology, Department of 221 Important Role For Mast Cells But Not Basophils In An Adju- Pediatrics,Northwestern University Feinberg School of Medicine, vant-Free Model Of Active Anaphylaxis In Mice 4Division of Allergy & Immunology, Department of Pediatrics, Dr. Laurent L. Reber, PhD 1, Dr. Hajime Karasuyama, MD, PhD 2, Northwestern University Feinberg School of Medicine, Ann & Rob- Dr. Mindy Tsai, DMSc 1 and Dr. Stephen J. Galli, MD 1, 1Stanford ert H. Lurie Children’s Hospital of Chicago, Chicago, IL University School of Medicine, Stanford, CA, 2Tokyo Medical 229 Early and Significant Improvement In The Intensity Of Allergic and Dentistry Graduate School, Tokyo, Japan Rhinitis Symptoms After Treatment With Intranasal Cicleso- 222 Functional Phenotype Of CD49d-Expressing Neutrophils Dif- nide 200 Mcg Qd: Open Trial In Mexican Population fers Between Viral Infection and TLR Stimulation Francisco Javier Saynes-Marin 1, Araceli Arellano-Plancarte 2, Dr. Dorothy S. Cheung, MD, FAAAAI , Erika Buell, Mrs. Desire Jazmin Chiu-Ugalde2, Estefania Torres-Medina 2, Jose Antonio Var- Hunter and Dr. Mitchell H. Grayson, MD, FAAAAI, Medical Col- gas-Romero2 and Juan Carlos Lopez-Alvarenga 2,3, 1Hospital An- lege of Wisconsin, Milwaukee, WI geles Metropolitano, Mexico City, Mexico, 2Medical Department, 223 Mast Cells Preferentially Migrate To Denatured Collagens Takeda M exico S.A. de C.V., Edo. de M ex., Mexico, 3Direccion Compared To Native Collagens de Investigaci on, Hospital General de M exico ‘‘Eduardo Liceaga’’, Thomas Kaido1, Robert T. Reid 1, Anthony Montgomery 2 and Ri- Mexico City, Mexico chard Reid1, 1The Banck Center, San Diego, CA, 2University of 230 Viral Induced Ibuprofen Sensitivity Leading To Anaphylaxis In California San Diego, San Diego, CA Preschool Aged Children 224 Expression Of The Transcription Factor E4BP4 In Human Ba- Mrs. Jodi A. Shroba, RN MSN CPNP and Ms. Kathryn Choj- sophils nacki, Children’s Mercy Hospital Dr. Bettina M. Jensen , Mrs. Maria Gohr and Prof. Lars K. Poulsen, 231 Anthropomorphic Variations According To Clinical Pattern In PhD FAAAAI, Allergy Clinic, Copenhagen University Hospital - Cow’s Milk Allergic Children Gentofte, Hellerup, Denmark Ms. Diana Colson1, Prof. Nicolas Kalach, MD, Ph D 2, Ms. Pascale 225 Cross-Talk Between Human Mast Cells and Bronchial Epithe- Soulaines3 and Prof. Christophe Dupont, MD, PhD3,4, 1Nutricia lial Cells In The Production Of Plasminogen Activator Inhibi- Nutrition Clinique, Saint Ouen, France, 2Hopital^ Saint Vincent de tor-1 Via TGF- b1 Paul, Groupement des Hospitaux de l’Institut Catholique de Lille Dr. Seong Ho Cho, MD 1, Dr. Sun Hye Lee, PhD 1, Dr. Atsushi (GH-ICL), Lille, France, 3Hopital Necker Enfants Malades, Paris, Kato, PhD2, Dr. Tetsuji Takabayashi, MD 1, Dr. Soon Shin 1 and France, 4DBV Technologies, Paris, France Dr. Robert P. Schleimer, PhD FAAAAI 1, 1Division of Allergy-Im- 232 Development and Piloting Of a Food Allergy Education Pro- munology, Department of Medicine, Northwestern University Fein- gram For Parents Of Young Children berg School of Medicine, Chicago, IL, 2Department of Medicine, Ms. Catherine Gillespie, RN MN CAE 1, Ms. Nancy Ross, RN Division of Allergy-Immunology, Northwestern University Fein- CAE1, Dr. Nestor F. Cisneros, MD FRCPC 2 and Dr. Allan Becker, berg School of Medicine, Chicago, IL MD FRCPC 3, 1Children’s Hospital, Winnipeg, MB, Canada, 2Uni- versity of Manitoba, Winnipeg, MB, Canada, 3University Of Man- itoba, Winnipeg, MB, Canada 233 The Proficiency Status In The Use Of Inhaler and The Effect Of Education On Inhaler Technique Allied Health Saturday Poster Session Eun-Jung Jo, MD 1, Jung-Ha Mok, MD 1, Seung-Eun Lee, MD 2, Mi-Hyun Kim, MD 1, Kwangha Lee, MD, PhD 1, Ki-Uk Kim, 2214 MD, PhD1, Min-Ki Lee, MD, PhD 1 and Hye-Kyung Park, MD, Saturday, March 1st, 2014, 9:45 AM - 10:45 AM PhD1, 1Department of Internal Medicine, Pusan National University 226 Tolerability Of Two Different Immunoglobulin Intravenous School of Medicine, Busan, South Korea, 2Department of Internal Product In Patients With Primary Immunodeficiency Disease Medicine, Pusan National University Yangsan Hospital, Yangsan, Amanda Skoskiewicz, MSN, CPNP , Ann & Robert H. Lurie Chil- South Korea dren’s Hospital of Chicago, Chicago, IL, Melanie M. Makhija, MD, 234 The Natural History Of Hypersensitivity In Thai Chil- Division of Allergy & Immunology, Department of Pediatrics,- dren Northwestern University Feinberg School of Medicine, Chicago, Dr. Nunthana Siripipattanamongkol, MD , Mahidol university, IL; Ann and Robert H. Lurie Children’s Hospital of Chicago, Chi- Bangkok, Thailand cago, IL and Ramsay L. Fuleihan, MD, Division of Allergy & Im- 235 Development Of a Multidisciplinary Clinic To Improve Care Of munology, Department of Pediatrics, Northwestern University Adolescent Asthmatic Patients Ms. Lila C. Kertz, MSN RN Feinberg School of Medicine, Ann & Robert H. Lurie Children’s CPNP AE-C, Washington University, St. Louis, MO

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236 Food Allergy Herbal Formula-2 (FAHF-2) – Adherence To L.K. Znamenska1 and Prof. Lawrence M. DuBuske, MD, Treatment FAAAAI 2, 1Crimean State Medical University, Ukraine, 2George Jaime Ross, RN 1, Suzanne K. Carlisle, RN BSN CCRP 2, Maripaz Washington University School of Medicine, DC Vazquez, RN, BSN, CDE 3, Stacie M. Jones, MD 4, Dr. Jacqueline Pon- gracic, MD, FAAAAI 5 and Dr. Julie Wang, MD, FAAAAI 1, 1The Icahn School of Medicine at Mount Sinai, New York, NY, 2University of Arkansas for Medical Sciences, Little Rock, AR, 3Division of Al- Mechanisms and Immunotherapy lergy and Immunology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, Chicago, IL, 4Slot 512-13, University of Ar- 2602 kansas for Medical Sciences, Little Rock, AR, 5Ann & Robert H. Lurie Saturday, March 1st, 2014, 2:00 PM - 3:15 PM Children’s Hospital of Chicago, Chicago, IL 244 The Utility Of Anti-Pneumococcal Antibody Measurement In Pa- 237 Adapting Waiting-List For Allergy By Health Care On-Line: Co- tientsWith Primary Immunodeficiency Receiving Immunoglobulin ordination Between Providers and Allergist In The Public System Dr. Stephen Jolles , Dr. Adrian Heaps, Dr. Mo and Dr. Rachel   1 2 Dr. Inmaculada S anchez-Mach ın, MD , Dr. Paloma Poza Guedes , Jones, University Hospital of Wales, Cardiff, United Kingdom 1 3 Dr. Ruperto gonzalez Perez , Dr. Yvelise Barrios, MD, PhD and Dr. 245 Diagnostic Immunization With Bacteriophage FX 174 In Pa- 1 1  Victor Matheu, MD , Hospital del T orax-Ofra, Sta Cruz de Tenerife, tients With Common Variable Immunodeficiency/Hypogamma- 2  3 Spain, Hospital Ofra-T orax, santa cruz de tenerife, Spain, Hospital globulinemia Universitario de Canarias, Tenerife, Spain Dr. Lauren Smith, MD 1, Dr. Rebecca H. Buckley, MD, FAAAAI 1 238 Aerobiology Of Texas Panhandle and Efficiency Of AHPCO and Dr. Patricia L. Lugar, MD, MS 2, 1Department of Pediatrics, Technology As Air Purifier, Surface Sterilizer In Food Processing Duke University Medical Center, Durham, NC, 2Duke University 1 Dr. Nabarun K. Ghosh, PhD , Dr. Constantine K. Saadeh, MD, Medical Center, Durham, NC 2 3 FAAAAI , Dr. Jeff Bennert, PhD CTN and Ms. Griselda Estrada, 246 Immunochip Study Reveals Regions On Chromosomes 2 and 6 1 1 2 BS , West Texas A&M University, Canyon, TX, Allergy ARTS May Contribute To The Spectrum Of CVID 3 ACCR, Amarillo, TX, AIR OASIS, Amarillo, TX Dr. Tracy Hwangpo, MD/PhD 1, Ewa Szymanksa, PhD 1, Mrs. Marsha Brand 1, Dr. Peter Gregerson, MD 2, Dr. Peter Burrows, PhD 3, Dr. Elizabeth Brown, PhD 4, Dr. Richard Reynolds, PhD 5 and Dr. Harry Schroeder, MD/PhD 6, 1UAB, 2The Feinstein Institute for Medical Re- Novel Genetic Factors in Asthma search, 3UAB, Department of Microbiology, 4UAB,Department of Ep- idemiology, 5UAB, Department of Medicine, 6UAB, Department of Medicine and Department of Microbiology, AL 2601 247 Rule Of Different Memory Cells In Common Variable Immuno- Saturday, March 1st, 2014, 2:00 PM - 3:15 PM deficiency and Specific Antibody Deficiency 239 IL-33 and IL1RL1 Single Nucleotide Polymorphisms and Their Amer M. Khojah, MD , Umm Al Qura Univirsity, Makkah, Saudi Association With Asthma Among Puerto Ricans Arabia; Inova Fairfax Hospital for children, Fall Church, VA, Oral Dr. Javier A. Mendez, MD , Dr. Sylvette Nazario, MD, Dr. Angel Alpan, MD, Amerimmune, LLC, VA; O&O ALPAN, LLC and Laureano, MD, Dr. Adriana Baez, PhD and Ms. Bianca Rivera, Ameera Bukhari, MS, Taif University, Saudi Arabia PhDc, University of Puerto Rico School of Medicine, San Juan, PR 248 Evaluation of a Novel Missense Activation-Induced Deaminase 240 Genetic Effect Of Single-Nucleotide Polymorphisms In The AID Mutation in a Child with Hyper IgM Syndrome: Is it a PPARGC1B Gene On Airway Hyperreactivity In Asthmatic Pa- Pathogenic Mutation? tients Dr.Ottavia M. Delmonte, M.D. , Pediatric Residency Program, Boston Dr. Jong-Sook Park, MD , Dr. Myung-Sin Kim, Dr. Sung-Woo Children’s Hospital, Harvard Medical School, Boston, MA, Dr. Feilong Park, Dr. An-Soo Jang and Dr. Choon-Sik Park, MD, Soonchun- Meng, PhD, Howard Hughes Medical Institute, Program in Cellular and hyang University Bucheon Hospital, Bucheon, South Korea Molecular Medicine and Immune Disease Institute, Boston Children’s 241 Polymorphisms In IL10, TGFB, TLR4, TLR8 and ADBR2 Genes Hospital, Department of Genetcis, Harvard Medical School, Boston, Resulted Associated To Asthma In Brazilian Family Trio Study MA, Dr. Frederick Alt, PhD, Howard Hughes Medical Institute, Pro- Mrs. Isabel Rugu^e Genov, MD , Federal University of S ~ao Paulo, gram in Cellular and Molecular Medicine and Immune Disease Insti- S~ao Paulo, Brazil, Mrs. Angela Falcai, PhD, ICB USP, S ~ao Paulo, tute, Boston Children’s Hospital, Department of Genetics, Harvard Brazil, Dr. Lucila Camargo, MD, UNIFESP, S ~ao Paulo, Brazil, Dr. Medical School, Boston, MA, Dr. Luigi D. Notarangelo, MD, Division Marcia Mallozi, MD, Federal University of S ~ao Paulo, Brazil, Dr. of Immunology, Boston Children’s Hospital, Harvard Medical School, Virginia Ferriani, MD, PhD, School of Medicine of Ribeirao Preto- Boston, MA; The Manton Center for Orphan Disease Research, Boston University of Sao Paulo, Brazil, Prof. Alessandra Pontillo, PhD, Uni- Children’s Hospital, Boston, MA and Dr. Jolan E. Walter, MD, PhD, Di- versity of S ~ao Paulo, Brazil, Prof. Antonio Condino-Neto, MD, PhD, vision of Allergy/Immunology, Massachusetts General Hospital for Institute of Biomedical Sciences, Department of Immunology, Uni- Children, Harvard Medical School, Boston, MA versity of S ~ao Paulo, Sao Paulo, Brazil and Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil 242 Genetic Variation Along The Histamine Pathway In Children With Allergic Vs. Non-Allergic Asthma Asthma Environmental Risk Factors and Dr. Sara Anvari, MD 1, Dr. Carrie A. Vyhlidal, PhD 2, Mo Rezaie- khaligh, MS 2, Dr. Hongying Dai, PhD 2 and Dr. Bridgette L. Jones, Infections MD, FAAAAI 1,2, 1Children’s Mercy Hospital & Clinics, Division of Allergy, Asthma and Immunology, Kansas City, MO, 2Children’s 2603 Mercy Hospital & Clinics, Division of Pediatric Clinical Pharma- Saturday, March 1st, 2014, 2:00 PM - 3:15 PM cology, Kansas City, MO 249 Surfactant Protein A (SP-A) Reduces Human Rhinovirus 16 243 Association Of Polymorphism At The CD14 Promoter (CD14- (RV16)-Induced Inflammatory Responses In Bronchial Epithe- C159T) With Atopic and Non-Atopic Asthma In Adults From lial Cells and Inhibits Viral Replication In H1-HeLa Cells Crimea, Ukraine Sasipa Tanyaratsrisakul, PhD 1, Ying Wang, MD 2, Monica Kraft, Dr. Yuri Bisyuk 1, Prof. V.A. Beloglazov 1, Dr. A.I. Dubovyi 1, Dr. MD 2, Mari Nakamura, MD 1 and Prof. Dennis R. Voelker, PhD 1,

98 J ALLERGY CLIN IMMUNOL Abstracts AB309 VOLUME 133, NUMBER 2

1Department of medicine, National Jewish Health, Denver, CO, 2De- PhD, FAAAAI 4, Prof. Anne-Louise Ponsonby, PhD 1, Dr. Melanie partment of Medicine, Duke University Medical Center, Durham, NC Matheson, PhD 3, Dr. David Hill, MBBD, FRACP 1 and Prof. Katrina 250 The Home Microbiome and Childhood Asthma Jane Allen, MD, PhD, FAAAAI 1,5 , 1Murdoch Childrens Research Dr. Christina E. Ciaccio, MD, FAAAAI , Mr. Kevin Kennedy, Institute, Victoria, Australia, 3University of Melbourne, Victoria, Aus- MPH CIEC, Prof. Charles S. Barnes, PhD, Dr. Jay M. Portnoy, tralia, 4The University of Melbourne, Melbourne, Australia, 5Royal MD, FAAAAI and Dr. Lanny J. Rosenwasser, MD, FAAAAI, Chil- Children’s Hospital, Victoria, Australia dren’s Mercy Hospital, Kansas City, MO 256 Exome Chip Genotyping Reveals Association With PDE4C and 251 Effect Of Prenatal Antioxidant Intake On Infants’ Respiratory Atopic Dermatitis In Populations Of European and African De- Infection scent Dr. Eun Lee 1, Seo Ah Hong 2, Dr. Song I Yang, MD 1, Prof. Kyung Nicholas M. Rafaels 1, Lili Huang, MPH 1, Donald Y.M. Leung, MD, Won Kim, MD, PhD 3, Prof. Youn Ho Shin 4, Kang Mo Ahn 5, Dr. PhD, FAAAAI 2, Lisa A. Beck, MD, FAAAAI 3, Dr. Candelaria I. Ver- Soo-Jong Hong, MD, PhD1 and And the COCOA study group, 1De- gara, MD, PhD1, Dr. Mark Boguniewicz, MD, FAAAAI 2, Dr. Tissa

partment of Pediatrics, Childhood Asthma Atopy Center, Research Hata, MD 4, Dr. Lynda C. Schneider, MD, FAAAAI 5, Dr. Jon M. Ha- SATURDAY Center for Standization of Allergic Diseases, Asan Medical Center, nifin, MD, FAAAAI 6, Dr. Richard Gallo, MD, PhD 7, Dr. Li Gao, MD, University of Ulsan College of Medicine, Seoul, Korea, 2Asan Insti- PhD1, Dr. Ingo Ruczinski, PhD 8, Dr. Rasika A. Mathias, ScD 1 and Dr. tute for Life Sciences, University of Ulsan College of Medicine, Kathleen C. Barnes, PhD FAAAAI 1, 1Division of Allergy and Clini- Seoul, Korea, 3Department of Pediatrics, Severance Children’s Hos- cal Immunology, Department of Medicine, Johns Hopkins Univer- pital, College of Medicine, Yonsei University, Seoul, Korea, Seoul, sity, Baltimore, MD, 2National Jewish Health, Denver, CO, South Korea, 4Department of Pediatrics, CHA Medical Center, 3University of Rochester Medical Center, Rochester, NY, 4University CHA University School of Medicine, Seoul, Korea, South Korea, of California, San Diego, San Diego, CA, 5Boston Children’s Hospi- 5Department of Pediatrics, Samsung Medical Center, Sungkyunkwan tal, Boston, MA, 6Oregon Health & Science University, Portland, University School of Medicine, Seoul, Korea, South Korea OR, 7Division of Dermatology, University of California, San Diego, 252 Epidermal Growth Factor Receptor (EGFR) Mediates Cell Fu- San Diego, CA, 8Johns Hopkins University School of Public Health, sion and Infectivity Of Respiratory Syncytial Virus (RSV) Baltimore, MD Sujin Lee1,2, Michael G. Currier 1,2, Anne L. Hotard 1,2, Jia Meng 1,2, 257 Exploring a Role for Laminin Proteins in the Pathogenesis of Carla Pretto1,2, Ultan F. Power 3, Remi Villenave 3, Michael D. Atopic Dermatitis Shields3,4, Michael H. Chi 5, R. Stokes Peebles 6 and Martin L. Erin J. Klaffky, MD, PhD , Rachana Agrawal, PhD and Judith A. Moore1,2, 1Department of Pediatrics, Emory University, GA, 2Chil- Woodfolk, MBChB, PhD, FAAAAI, University of Virginia, Char- dren’s Healthcare of Atlanta, GA, 3Centre for Infection and Immu- lottesville, VA nity, School of Medicine, Dentistry and Biomedical Science, 258 Thymic Stromal Lymphopoietin and Interleukin-33 Promote Queens University Belfast, Northern Ireland, 4The Royal Belfast Skin Inflammation and Containment Of Vaccinia Virus In A Hospital for Sick Children, Northern Ireland, 5Allergy, Pulmonary, Mouse Model Of Atopic Dermatitis and Critical Care Medicine; Department of Medicine; Vanderbilt Dr.Michiko K.Oyoshi,PhD, MSc , Ms. Jacqueline Beaupr e, Mr. Nich- University School of Medicine, TN, 6Allergy, Pulmonary, and Crit- olas Venturelli and Raif S. Geha, MD, Division of Immunology, Boston ical Care Medicine, Department of Medicine, Vanderbilt University Children’s Hospital, Harvard Medical School, Boston, MA School of Medicine, Nashville, TN 253 Cluster Analysis Of An Inner-City Cohort Of Infant Wheezers Dr. Monica B. Reddy, MD 1, Andrew H. Liu, MD 2, Allison Schiltz1,2, Mrs. Anna Forssen, MS 2 and Dr. Mary D. Klinnert, PhD1,2, 1University of Colorado School of Medicine, 2National Health Disparities Jewish Health, Denver, CO 2605 Saturday, March 1st, 2014, 2:00 PM - 3:15 PM 259 What Really Happens In The Home: The Medication Environ- ment Of Urban, Minority Youth Atopic Dermatitis Dr. Molly Martin, MD, MAPP and Andrea A Pappalardo, MD, Rush University Medical Center, Chicago, IL 2604 260 Young, African American Adults With Asthma: What Matters Saturday, March 1st, 2014, 2:00 PM - 3:15 PM To Them? 254 A Randomized, Multi-Center, NIH/NIAID Funded Study To As- Dr.Aimee L. Speck, M.D. 1, Dr. Belinda Nelson, PhD 2, Mrs. S. Olivia sess The Immunogenicity Of Fluzone Ò Intradermal and Intra- Jefferson, MSW3 and Dr. Alan P.Baptist, MD, MPH FAAAAI 1, 1Uni- muscular Vaccines In Atopic Dermatitis versity of Michigan, Division of Allergy and Clinical Immunology, Donald Y.M. Leung, MD, PhD, FAAAAI 1, Lisa A. Beck, MD, Ann Arbor, MI, 2University of Michigan, Health Behavior and Health FAAAAI 2, Dr. Jon M. Hanifin, MD, FAAAAI 3, Dr. Lynda C. Education, School of Public Health, Ann Arbor, MI, 3University of Schneider, MD, FAAAAI 4, Dr. Amy Paller, MD 5, Dr. Gloria David, Michigan, Department of Health Behavior and Health Education, PhD6, Ms. Katherine Monti 6, Mr. Brett Jepson 6 and Dr. Adriana School of Public Health, Ann Arbor, MI Weinberg, MD 7, 1National Jewish Health, Denver, CO, 2University 261 Language Disparities Among Minority Patients with Poor of Rochester Medical Center, Rochester, NY, 3Oregon Health & Asthma Control Science University, Portland, OR, 4Boston Children’s Hospital, Dr. Jose R. Zaragoza-Buxo, MD , Penn State University College of Boston, MA, 5Northwestern University Feinberg School of Medi- Medicine, Hershey, PA and Dr. Efren L. Rael, MD, FAAAAI, Al- cine, Chicago, IL, 6Rho, Inc., Chapel Hill, NC, 7University of Col- lergy/Immunology, Penn State University College of Medicine, orado Heath Sci Ctr., Denver, CO Hershey, PA 255 Which Infants With Eczema Are At Risk Of Food Allergy? Re- 262 Race/Ethnicity and SES Are Predictors Of Allergic Sensitiza- sults From A Population Based Study tion To Environmental and Food Allergens Dr. Jana K. Eckert, PhD 1, Dr. Pamela Martin, PhD 1, Dr. Adrian Dr. Amina Abdeldaim, MD 1, Dr. Supinda Bunyavanich, MD, Lowe, PhD 1,3 , Dr. Jennifer Koplin, PhD 1, Prof. Shyamali Dharmage, MPH2, Ms. Sheryl Rifas-Shiman, MPH 3, Thomas A.E. Platts-Mills, MD, PhD 1,3 , Prof. Lyle Gurrin, PhD 1,3 , Prof. Mimi L. K. Tang, MD, MD, PhD, FAAAAI 4, Dr. Diane R. Gold, MD, MPH 5, Dr. Carlos

99 AB310 Abstracts J ALLERGY CLIN IMMUNOL

SATURDAY FEBRUARY 2014

Camargo Jr., MD, DrPH 6, Dr. Emily Oken, MD 7, Dr. Matthew Gill- 267 Role Of Basophil Activation Test For Identifying Subjects With man, MD, SM 3 and Dr. Augusto A. Litonjua, MD, MPH 8, 1Channing Local Allergic Rhinitis Division of Network Medicine, Brigham and Women’s Hospital, Dr. Paloma Campo, MD, PhD 1, Dr. Carmen Rondon, MD, PhD 1, MA, 2Division of Pediatric Allergy & Immunology, Department of Dr. Enrique G omez, PhD2, Dr. Esther Barrionuevo Sanchez 1, Mrs. Pediatrics, Icahn School of Medicine at Mount Sinai, New York, Luisa Galindo, RN 1, Mr. JA Huertas 1, Dr. Cristobalina Mayorga, NY, 3Harvard Medical School, Boston, MA, 4Division of Asthma, Al- PhD2 and Dr. Miguel Blanca, MD, PhD 1, 1Allergy Service, Carlos lergy & Immunology, University of Virginia Health System, Charlot- Haya Hospital, Malaga, Spain, 2Research Laboratory for Allergic tesville, VA, 5Channing Laboratory, Brigham and Women’s Hospital, Diseases, Hospital Regional Universitario de Malaga - IBIMA, Boston, MA, 6Department of Emergency Medicine, Massachusetts Malaga, Spain General Hospital, Harvard Medical School, Boston, MA, 7Harvard 268 Does Serum Leptin Differ Between Patients With Rhinitis Of Medical School, 8Channing Division of Network Medicine, Brigham Allergic Vs Nonallergic Aetiology? and Women’s Hospital, Boston, MA Prof. Ayse Fusun Kalpaklioglu, MD and Dr. Ayse Baccioglu, MD, 263 Unrecognized Allergic Rhinoconjunctivitis and Allergic Sensiti- Kirikkale University Faculty of Medicine Department of Allergic zation Among Latino Youth (GALA II Study) Diseases Ulysses Burley, MPH 1, Dr. Joy Hsu, MD, MSCI 2, Duanny Alva, MD-IMG, MPH1, Ms. Elizabeth Nguyen, BS 3, Ms. Lindsey Roth, MA 4, Dr. Joshua Galanter, MD 4, Dr. Sam Oh, PhD, MPH 4, Ms. Ce- leste Eng, BS 4, Mr. Fred Lurmann, MS 5, Dr. Rajesh Kumar, MD, Mechanisms of Steroid and Arachidonic Acid MS, FAAAAI 6, Dr. Harold J. Farber, MD, MSPH 7, Dr. Denise Ser- ebrisky, MD 8, Dr. Luisa Borrell, DDS, PhD 9, Dr. Saunak Sen, Pathways in Allergic Disease PhD10 , Dr. William Rodriguez-Cintron, MD 11 , Dr. Jose Rodriguez- Santana, MD 12 , Dr. Esteban Gonza Burchard, MD, MPH 4 and Prof. 2607 Pedro C. Avila, MD, FAAAAI 1, 1Feinberg School of Medicine, Saturday, March 1st, 2014, 2:00 PM - 3:15 PM Northwestern University, Chicago, IL, 2Department of Medicine, Di- 269 LTC4, But Not LTD4 Or LTE4, Activates Platelets Through a vision of Allergy-Immunology, Northwestern University Feinberg CysLT2R and P2Y12 Receptor-Dependent Pathway School of Medicine, Chicago, IL, 3Department of Medicine, Univer- Dr. Joshua A. Boyce, MD, FAAAAI 1,2, Dr. Tao Liu, PhD 1,2 and sity of California, San Francisco, California, San Francisco, CA, 4De- Dr. Hannah Cummings, PhD 1,2, 1Harvard Medical School, Boston, partment of Medicine, University of California, San Francisco, San MA, 2Brigham and Women’s Hospital, Division of Rheumatology, Francisco, CA, 5Sonoma Technology, Inc., Petaluma, CA, 6Pediatric Immunology and Allergy, Boston, MA allergy, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chi- 270 Predictors Of Response To Glucocorticoids In Hypereosino- cago, IL, 7Baylor College of Medicine and Texas Children’s Hospital, philic Syndromes Houston, TX, 8Pediatric Pulmonary Division, Jacobi Medical Center, Paneez Khoury, MD 1, Annalise Abiodun, RN 1, Kelli Williams, Bronx, NY, 9Department of Health Sciences, Graduate Program in MD, M.P.H.1, JeanAnne Ware, CRNP 1, Nicole Holland-Thomas, Public Health, Lehman College, City University of New York,Bronx, MSN, RN 2 and Dr. Amy D. Klion, MD 1, 1National Institutes of NY, 10 Department of Epidemiology and Biostatistics, University of Health, Bethesda, MD, 2SAIC-Frederick Inc., Bethesda, MD California, San Francisco, San Francisco, CA, 11 Veterans Caribbean 271 Differential Proteomic Analysis Of Eosinophils From Patients Health Care System, San Juan, PR, 12 Centro de Neumologia Pedia- With Glucocorticoid Responsive Or Resistant Hypereosino- trica, San Juan, PR philic Syndrome Konrad Pazdrak, MD, PhD 1, Paneez Khoury, MD 2, Kizhake V. Soman, PhD1, Nicole Holland-Thomas, MSN, RN 3, Mrs. Michelle Makiya2, Christof Straub, PhD 1, Zheng Wu, PhD 1, Dr. Amy D. Klion, MD 2 and Alexander Kurosky, PhD 1, 1University of Texas Local Allergic Rhinitis and Non-Allergic Rhinitis Medical Branch, Galveston, TX, 2National Institutes of Health, Be- thesda, MD, 3SAIC-Frederick Inc., Bethesda, MD 2606 272 Glucocorticoid Receptor- a^ Up-Regulation In C57BL/6 Diet-In- Saturday, March 1st, 2014, 2:00 PM - 3:15 PM duced Obese Mice With House Dust Mite-Mediated Asthma 264 The Nasal NO Response To External Acoustic Energy: A Pilot Dr. Jennifer Diaz, MD 1,2, Dr. Malvika Solanki, MBBS, MPH 3, Dr. Study Xiangying Xue, MD 3, Prodyot Chatterjee, PhD 3, Dr. Madhu Gupta, Dennis Shusterman, MD, MPH , University of California, San MBBS3, Dr. Vincent R. Bonagura, MD, FAAAAI 4 and Christine Francisco, Richmond, CA Metz, PhD3, 1Feinstein Institute for Medical Research, Manhasset, 265 Flagellin/Toll-Like Receptor 5 Induces Interleukin-17C In Hu- NY, 2Allergy and Immunology, North Shore-LIJ Health System, man Nasal Epithelia Great Neck, NY, 3Feinstein Institute for Medical Research, NY, Dr. Hyun Jin Min 1, Dr. Tae-Hoon Kim 2, Su-Yeon Choi 2, Prof. Joo- 4Division of Allergy/Immunology, Departments of Medicine and Heon Yoon 1,2 and Prof. Chang-Hoon Kim1,3, 1Department of Oto- Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great rhinolaryngology, Yonsei University College of Medicine, Seoul, Neck, NY South Korea, 2Research Center for Human Natural Defense System, 273 Reduced EP2 Receptor Expression Accounts For Prostaglandin Yonsei University College of Medicine, Seoul, South Korea, 3The E2 Resistance In Fibroblasts From Patients With Airway Mucus Institute, Yonsei University College of Medicine, Aspirin Exacerbated Respiratory Disease; Possible Role For Seoul, South Korea Histone Acetylation In Control Of EP2 Receptor Expression 266 Phenotyping Non-Allergic and Local Allergic Rhinitis Dr. Katherine N. Cahill, MD 1,2, Mr. Derek Thibault 3, Dr. Benja- Dr. Carmen Rondon, MD, PhD 1, Dr. Paloma Campo, MD, PhD 1, min A. Raby, MD, MPH 3, Dr. Andrea Baccarelli, MD, MPH Dr. Esther Barrionuevo Sanchez, MD 1, Ms. Cristina De Leiva Mo- PhD4, Dr. Neil Bhattacharyya, MD 2,3, Dr. Joshua A. Boyce, MD, lina1, Dr. Leticia Herrero Lifona, MD, PhD 1, Ms. Maria Auxiliadora FAAAAI 1,2 and Dr. Tanya M. Laidlaw, MD, FAAAAI 1,2, 1Brigham Guerrero1, Dr. Francisca G omez, MD, PhD1, Dr. Natalia Blanca- and Women’s Hospital, Division of Rheumatology, Immunology Lopez, MD, PhD2, Dr. Gabriela Canto, MD, PhD 2 and Dr. Miguel and Allergy, Boston, MA, 2Harvard Medical School, Boston, MA, Blanca, MD, PhD1, 1Allergy Service, Carlos Haya Hospital, M alaga, 3Brigham and Women’s Hospital, Boston, MA, 4Harvard School Spain, 2Allergy Service, Infanta Leonor Hospital, Madrid, Spain of Public Health, Boston, MA

100 J ALLERGY CLIN IMMUNOL Abstracts AB311 VOLUME 133, NUMBER 2

Bronchoprovocation and Asthma Comorbidities 284 Exercise-Induced Bronchospasm In Adolescents: Characteris- tics Of Lung Function and Accuracy Of Symptoms 3201 Mr. Daniel Andrade Hygidio 1, Ms. Beatriz Schwinden 1, Dr. Paulo Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Freitas1 and Dr. Jane Da Silva 1,2, 1University of Southern Santa ~ 2  274 Association Between Body Mass Index (BMI) and Fraction Of Catarina - UNISUL, Tubar ao - SC, Brazil, Hospital Universitario ~  Exhaled Nitric Oxide (FeNO) Levels In The National Health Polydoro Ernani de S ao Thiago - HU/UFSC, Florian opolis - SC, and Nutrition Examination Survey (NHANES) 2007-2010 Brazil Dr. Sindhura Gogineni, MD , Dr. Joseph Espiritu and Dr. Aditya 285 Variation Of Bronchial Hyperresponsiveness According To Age Uppalapati, MD, St. Louis University, St. Louis, MO 275 Daily and Gender In Pediatric Population 1 2 Global Stress Is Associated With Nocturnal Awakenings Due Dr. Young Ho Kim, MD , Dr. Eun Lee, MD , Dr. Song I Yang, 2 2 3 To Asthma In School-Age Children MD , Dr. Young Ho Jung, MD , Dr. Hyung Young Kim, MD , 4 5 Dr. Caroline C. Horner, MD, FAAAAI 1, Courtney Dula, MS 1, Dr. Dr. Ju-Hee Seo, MD , Dr. Byoung-Ju Kim, MD, PhD , Dr. Hyo- 6 7 Leonard B. Bacharier, MD, FAAAAI 2, Dr. Jane Garbutt, MBChB 1, Bin Kim, MD, PhD , Prof. So Yeon Lee, MD, PhD , Prof. Dae 8 9 Dr. Robert C. Strunk IV, MD, FAAAAI 1, Mr. Carlos Gonzalez, Jin Song, MD, PhD , Prof. Woo Kyung Kim, MD, PhD , Dr. 10 MS 1, Ms. Elena Deych, MS 1 and Dr. William Shannon, PhD 1, Gwang Cheon Jang, MD, PhD , Prof. Jung Yeon Shim, MD, 11 2 1Washington University School of Medicine, Saint Louis, MO, 2De- PhD , Prof. Jinho Yu, MD, PhD , Prof. Soo-Jong Hong, MD. 12 13 1 partment of Pediatrics, Washington University School of Medicine PhD and Dr. Ji-Won Kwon, MD , Department of Pediatrics, and St. Louis Children’s Hospital, Saint Louis, MO Seoul National University Bundang Hospital, Seongnam, South Ko- 2 276 A Seven Minute High Intensity Workout Is Well Tolerated In rea, South Korea, Childhood Asthma Atopy Center, Department of Adults With Asthma and Results In Decreased Salivary Leuko- Pediatrics, Asan Medical Center, University of Ulsan College of 3 trienes Medicine, Seoul, South Korea, Department of Pediatrics, Kosin Dr. Katherine G. Conner, MD 1, Dr. Meaghan Misiasz, M.D. 1, Dr. University Gospel Hospital, Kosin University College of Medicine, 4 Maria Talamo 2, Ms. Caitlin Campion 1, Julie McDaniel 1, Dr. Jun Fu, Seoul, South Korea, Department of Pediatrics, Korea Cancer Cen- 5 PhD 1 and James N Moy, MD 1,2 , 1Rush University Medical Center, Chi- ter Hospital, Seoul, South Korea, Department of Pediatrics, Hae- cago, IL, 2John H. Stroger Hospital of Cook County, Chicago, IL undae Paik Hospital, Inje University College of Medicine, Busan, 6 277 Obesity and Depression Affecting Asthma Morbidity: An Anal- South Korea, Department of Pediatrics,Inje University Sanggye 7 ysis Of Montefiore Asthma Center’s Poorly Controlled Asth- Paik Hospital, Seoul, South Korea, Department of Pediatrics, Hal- 8 matics lym University College of Medicine, Seoul, South Korea, Depart- 1 1 ment of Pediatrics, Korea University Guro Hospital, Seoul, South Dr. Sunit Jariwala, MD , Dr. Jennifer Toh, MD and Dr. Sumita Si- SUNDAY 9 nha, MD 2, 1Albert Einstein/Montefiore Medical Center, New York, Korea, Department of Pediatrics, Seoul Paik Hospital, Inje Univer- 10 NY, 2Albert Einstein/Montefiore Medical Center, Bronx, NY sity College of Medicine, Seoul, South Korea, Department of Pe- 278 Psycho Social Stresses and Asthma Morbidity In Children diatrics, National Health Insurance Corporation Ilsan Hospital, 11 Dr. Ejaz Yousef, MD FAAAI , Marshfield Clinic, Marshfield, WI; Seoul, South Korea, Department of Pediatrics, Kangbuk Samsung Marshfield Clinic, Marshfield, WI Hospital, Sungkyunkwan University College of Medicine, Seoul, 12 279 Does The Sinusitis Affect Bronchial Hyperresponsiveness In South Korea, Research Center for Standardization of Allergic Asthmatic Children ? Disease, University of Ulsan College of Medicine, Seoul, Korea, 13 Chikako Motomura , Dr. Hiroshi Odajima, Yuko Amimoto, Rin- Department of Pediatrics, Seoul National University Bundang taro Ono, Keisuke Watanuki, Yoko Murakami, Naohiko Taba, Sa- Hospital, Seoul National University College of Medicine, Seong- toshi Honjho and Sankei Nishima, Fukuoka National Hospital, nam, South Korea Fukuoka, Japan 286 Nasal Provocation Test In The Diagnosis Of Mite Allergic Rhi- 280 Allergic Bronchopulmonary Mycosis. Are We Overdiagnosing nitis : Standard Or Rapid ? In Cape Town, South Africa? Prof. Frederic de BLAY , Dr. Celine Lutz, Dr. Mael Bellier, Prof. Dr. Tamara Kerbelker, MBChB , Red Cross War Memorial Chil- Jean Jacques Braun and Mrs. Brigitte Sbinne, CHRU Strasbourg, dren’s Hospital, Cape Town, South Africa France 281 Risk Factors For Postoperative Pulmonary Complications After 287 Nocturnal Asthma In Latino Children Is Associated With Se- Noncardiothoracic Surgery In Adult Asthma Patients vere Disease and Allergenic Triggers (GALA II Study) 1 1 Seung-Eun Lee, MD 1,2 , Eun-Jung Jo, MD 2, Hye-Kyung Park, MD 2, Dr. Geeta Bhargave, MD , Dr. Joy Hsu, MD, MSCI , Ms. Eliza- 2 3 Woo-Hyeon Cho, MD 1,2 , Doo-Soo Jeon, MD 1,2 and Prof. Yun-Seong beth Nguyen, BS , Ms. Lindsey Roth, MA , Dr. Joshua Galanter, 3 3 3 Kim,MD 1,2 , 1Respiratory and allergyclinic, Pusan National University MD , Dr. Sam Oh, PhD, MPH , Ms. Celeste Eng, BS , Mr. Fred 4 5 Yangsan Hospital, South Korea, 2Department of Internal Medicine, Pu- Lurmann, MS , Dr. Harold J. Farber, MD, MSPH , Dr. Denise Ser- 6 7 san National University School of Medicine, South Korea ebrisky, MD , Dr. Luisa Borrell, DDS, PhD , Dr. Saunak Sen, 8 9 282 Rates Of Comorbidities Are Related To Level Of Asthma Con- PhD , Dr. William Rodriguez-Cintron, MD , Dr. Jose Rodriguez- 10 3 trol Santana, MD , Dr. Esteban Gonza Burchard, MD, MPH and 1 1 Dr. Mark Stevens, MD 1, Dr. Jeffrey R. Stokes, MD, FAAAAI 1, Prof. Pedro C. Avila, MD, FAAAAI , Feinberg School of Medi- 2 Ryan Walters, M.S. 2, Dr. Michael Schatz, MD, MS, FAAAAI 3 cine, Northwestern University, Chicago, IL, Department of Medi- and Dr. Thomas B. Casale, MD, FAAAAI 4, 1Creighton University cine, University of California, San Francisco, California, San 3 Medical Center, Omaha, NE, 2Creighton University, 3Kaiser Perma- Francisco, CA, Department of Medicine, University of California, 4 nente Southern California, San Diego, CA, 4Univeristy Of South San Francisco, San Francisco, CA, Sonoma Technology, Inc., Pet- 5 Florida Morsani College Of Medicine, Tampa, FL aluma, CA, Baylor College of Medicine and Texas Children’s Hos- 6 283 Rates Of Co-Morbidities Are Related To Asthma Severity pital, Houston, TX, Pediatric Pulmonary Division, Jacobi Medical 7 Dr. Jeffrey R. Stokes, MD, FAAAAI 1, Dr. Mark Stevens, MD 1, Center, Bronx, NY, Department of Health Sciences, Graduate Pro- Ryan Walters, M.S. 2, Dr. Michael Schatz, MD, MS, FAAAAI 3 gram in Public Health, Lehman College, City University of New 8 and Dr. Thomas B. Casale, MD, FAAAAI 4, 1Creighton University York, Bronx, NY, Department of Epidemiology and Biostatistics, 9 Medical Center, Omaha, NE, 2Creighton University, 3Kaiser Perma- University of California, San Francisco, San Francisco, CA, Vet- 10 nente Southern California, San Diego, CA, 4Univeristy Of South erans Caribbean Health Care System, San Juan, PR, Centro de Florida Morsani College Of Medicine, Tampa, FL Neumologia Pediatrica, San Juan, PR

101 AB312 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Biomarkers and Asthma Control I 8Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seong- nam, South Korea, 9Department of Pediatrics, Hae-undae Paik Hos- 3202 pital, Inje University College of Medicine, Busan, South Korea, Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM 10 Department of Pediatrics, Hae-undae Paik Hospital, Inje Univer- 288 Nasal Challenge With 50mgs Of L-Aspirin For Diagnosis Of sity College of Medicine, 11 Department of Pediatrics,Inje Univer- ASA Exacerbated Respiratory Disease sity Sanggye Paik Hospital, Seoul, South Korea, 12 Research Dr. Jose Manuel Reyna Guerra, MD , National Institute Of Respi- Center for Standardization of Allergic Diseases, Seoul, South Ko- ratory Diseases, Distrito Federal, Mexico rea, South Korea, 13 Department of Pediatrics, Hallym University 289 Clinical Usefulness Of Bronchial Mannitol Provocation Test In College of Medicine, Seoul, South Korea, 14 Department of Pediat- Children With Asthma Symptoms rics, Korea University Guro Hospital, Seoul, South Korea, 15 Depart- Dr. Young A. Park, MD 1, Hyun Bin Park, MD 1, Dr. Yoon Hee Kim, ment of Pediatrics, Seoul Paik Hospital, Inje University College of MD 1, Dr. Hee Seon Lee, MD 1, Dr. Yoon Ki Han, MD 1, Dr. Min Jung Medicine, Seoul, South Korea, 16 Department of Pediatrics, National Kim, MD 1, Hye Mi Jee, MD 2, Prof. Kyung Won Kim, MD, PhD 1, Health Insurance Corporation Ilsan Hospital, Seoul, South Korea, Prof. Myung Hyun Sohn, MD, PhD1 and Prof. Kyu-Earn Kim, MD, 17 Department of Pediatrics, Kangbuk Samsung Hospital, Sung- PhD1, 1Department of Pediatrics, Severance Children s Hospital, kyunkwan University College of Medicine, Seoul, South Korea College of Medicine, Yonsei University, Seoul, Korea, Seoul, South 293 Metabolomic Profiles Of Exhaled Breath Condensate In Asth- SUNDAY Korea, 2Department of Pediatrics, CHA University School of Medi- matics cine, Seongnam, Korea, South Korea Dr. Sandra Ho, MD 1, Dr. Bruce Luxon, PhD 1, Dr. Wendy Baker, 290 Salivary Alpha Amylase Activity Is a Potential Surrogate Bio- PhD1, Dr. Heidi Spratt, PhD 1, Dr. Rohit Divekar, MBBS, PhD 2, marker For Inhaled Beta-2 Agonist Responsiveness Emily Aaron1 and Dr. William J. Calhoun, MD, FAAAAI 1, 1Insti- Andrea A Pappalardo, MD 1,2, Jamie H Kiehm, MD 1, Caitlin M tute of Translational Sciences, University of Texas Medical Branch, Campion1, Dr. Larry L. Thomas, PhD 1 and James N Moy, MD 1,2, Galveston, TX, 2Division of Allergic Diseases, Mayo Clinic, Ro- 1Rush University Medical Center, Chicago, IL, 2John H. Stroger chester, MN Hospital of Cook County, Chicago, IL 294 Extended Nitric Oxide Analysis and Bronchial Hyperrespon- 291 Feno Decreases Significantly During Improved Symptom Con- siveness In Children With Asthma According To Atopy trol In Pediatric Patients After Acute Asthma Exacerbations Dr. Yoon Hee Kim, MD , Dr. Min Jung Kim, MD, Dr. Hee Seon Necessitating Emergency Department Care Lee, MD, Dr. Yoon Ki Han, MD, Dr. Young A. Park, MD, Prof. Dr. Eric M. Karlin, MD , Division of Allergy, Pulmonary, and Crit- Kyu-Earn Kim, MD, PhD, Prof. Kyung Won Kim, MD, PhD and ical Care Medicine, Department of Medicine, Vanderbilt University Prof. Myung Hyun Sohn, MD, PhD, Department of Pediatrics, Sev- School of Medicine, Nashville, TN, Tebeb Gebretsadik, MPH, De- erance Children’s Hospital, College of Medicine, Yonsei University, partment of Biostatistics, Vanderbilt University School of Medi- Seoul, Korea, Seoul, South Korea cine, Nashville, TN; Division of Allergy, Pulmonary, and Critical 295 Reference Values and Determinants Of Fractional Concentra- Care Medicine, Department of Medicine, and Center for Asthma tion Of Exhaled Nitric Oxide (FeNO) In Healthy Children and Environmental Sciences Research, Vanderbilt University Dr. Young Ho Jung, MD 1,2, Dr. Hyun Ju Cho, MD 1, Dr. Ji-Won School of Medicine, Nashville, TN, Dr. Emily W. Langley, MD, Di- Kwon, MD 2,3, Dr. Song I Yang, MD 1,2, Dr. Eun Lee, MD 1,4, Dr. vision of Allergy, Pulmonary, and Critical Care Medicine, Depart- Hyung Young Kim, MD 2,5, Dr. Ju-Hee Seo, MD 6,7, Dr. Byoung- ment of Medicine, Vanderbilt University School of Medicine, Ju Kim, MD, PhD 8,9, Dr. Hyo-Bin Kim, MD, PhD 9,10, Prof. So Nashville, Tennessee, Dr. Tina V. Hartert, MD, MPH, Vanderbilt Yeon Lee, MD, PhD 9,11, Prof. Dae Jin Song, MD, PhD 2,12, Prof. University School of Medicine, Nashville, TN, Dr. R. Stokes Pee- Woo Kyung Kim, MD, PhD 2,13, Dr. Gwang Cheon Jang, MD, bles Jr., MD, FAAAAI, Division of Allergy, Pulmonary and Critical PhD2,14, Prof. Jung Yeon Shim, MD, PhD 2,15 and Prof. Soo-Jong Care Medicine, Vanderbilt University School of Medicine, Nash- Hong, MD. PhD2,16, 1Childhood Asthma Atopy Center, Department ville, TN and Dr. Donald H. Arnold, MD, MPH, Center for Asthma of Pediatrics, Asan Medical Center, University of Ulsan College of and Environmental Health Sciences Research, Vanderbilt Univer- Medicine, Seoul, South Korea, 2Research Center for Standardiza- sity School of Medicine, Nashville, TN; Departments of Pediatrics tion of Allergic Diseases, Seoul, South Korea, 3Seoul National Uni- and Emergency Medicine, Vanderbilt University School of Medi- versity Bundang Hospital, Seoul National University College of cine, Nashville, Tennessee Medicine, 4childhood Asthma atopy center , asan medical center, 292 Risk Factors Of High Feno Levels & Cut-Off Value Of Feno In University of Ulsan College of Medicine, South Korea, 5Depart- Elementary School Children With Asthma ment of Pediatrics, Kosin University Gospel Hospital, Kosin Uni- Dr. Hyun Ju Cho, MD 1, Dr. Young-Ho Ho Jung, MD 1,2, Dr. Eun versity College of Medicine, Seoul, South Korea, 6Department of Lee, MD 1,3, Dr. Song I Yang, MD 1,4, Dr. Hyung Young Kim, Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea, 7De- MD 4,5, Dr. Ju-Hee Seo, MD 6,7, Dr. Ji-Won Kwon, MD 4,8, Dr. By- partment of pediatrics, Korea Cancer Center Hospital, South Korea, oung-Ju Kim, MD, PhD9,10, Dr. Hyo-Bin Kim, MD, PhD 11,12, 8Department of Pediatrics, Hae-undae Paik Hospital, Inje Univer- Prof. So Yeon Lee, MD, PhD 12,13, Prof. Dae Jin Song, MD, sity College of Medicine, Busan, South Korea, 9Research Center PhD4,14, Prof. Woo-Kyung Kim, MD, PhD 2,15, Dr. Gwang Cheon for Standardization of Allergic Diseases, Seoul, South Korea, South Jang, MD, PhD4,16, Prof. Jung Yeon Shim, MD, PhD 4,17 and Dr. Korea, 10 Department of Pediatrics,Inje University Sanggye Paik Soo-Jong Hong, MD, PhD1,2, 1Childhood Asthma Atopy Center, Hospital, Seoul, South Korea, 11 Department of Pediatrics, Hallym Department of Pediatrics, Asan Medical Center, University of Ul- University College of Medicine, Seoul, South Korea, 12 Department san College of Medicine, Seoul, South Korea, 2Research Center of Pediatrics, Korea University Guro Hospital, Seoul, South Korea, for Standardization of Allergic Disease, Seoul, South Korea, 3child- 13 Department of Pediatrics, Seoul Paik Hospital, Inje University hood Asthma atopy center , asan medical center, University of Ul- College of Medicine, Seoul, South Korea, 14 Department of Pediat- san College of Medicine, South Korea, 4Research Center for rics, National Health Insurance Corporation Ilsan Hospital, Seoul, Standardization of Allergic Diseases, Seoul, South Korea, 5Depart- South Korea, 15 Department of Pediatrics, Kangbuk Samsung Hospi- ment of Pediatrics, Kosin University Gospel Hospital, Kosin Uni- tal, Sungkyunkwan University College of Medicine, Seoul, South versity College of Medicine, Seoul, South Korea, 6Department of Korea, 16 Childhood Asthma Atopy Center, Department of Pediat- Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea, 7De- rics, Asan Medical Center, University of Ulsan College of Medi- partment of pediatrics, Korea Cancer Center Hospital, South Korea, cine, South Korea

102 J ALLERGY CLIN IMMUNOL Abstracts AB313 VOLUME 133, NUMBER 2

296 Improvement Of FENO In Youth With Asthma After Attending MD 1 and Dr. Osamu Kaminuma, PhD 2, 1National Hospital Organi- An Asthma Summer Camp zation, Sagamihara National Hospital, Sagamihara, Japan, 2Tokyo Dr. Jonathan A. Olsen, DO 1, Dr. Mark Stevens, MD 1, Mr. Patrick Metropolitan Institute of Medical Science, Tokyo, Japan Foster, B.S. 2 and Dr. Russell Hopp, DO, FAAAAI 3, 1Creighton 303 CD4+ T Cells From Nasal Polyp Explants Contain Abundant University Medical Center, Omaha, NE, 2American Lung Associa- Th2 Cells Expressing Functional Interleukin-25 Receptors To- tion, Omaha, NE, 3Creighton University School Medicine, Omaha, gether With Th17 Cells NE Mrs. Emily Lam, MSc1, Dr. Harsha H. Kariyawasam, MD, PhD 2, 297 Exhaled Nitric Oxide (FeNO) and T-Helper 2 Cell Biomarkers: Prof. Stephen R. Durham, MA MD FRCP 3, Ms. Joanne Rimmer, Can They Predict Treatment Response To Dupilumab, An IL- FRCS(ORL-HNS) 2, Dr. Valerie J. Lund, MD 2, Dr. David Cousins, 4R a Antibody, In An Eosinophilic Asthma Population? PhD1 and Dr. Stephen Till, MD, PhD 1, 1King’s College London, Brian N. Swanson, PhD 1, Lin Wang, PhD 1, Jeffrey Ming, MD 1, London, United Kingdom, 2Royal National Throat, Nose & Ear Jennifer D. Hamilton, PhD 2, Ariel Teper, MD 1, Thomas Dicioccio, Hospital London, University College London, London, United PhD2, Yongtao Li, PhD 1, Dr. Neil Graham, MD 2, Dr. Gianluca Pir- Kingdom, 3Imperial College London, London, United Kingdom ozzi, MD, PhD1 and Sally E. Wenzel, MD, FAAAAI 3, 1Sanofi, 304 Successful Desensitization To Paclitaxel For Stage 4 Ovarian Bridgewater, NJ, 2Regeneron Pharmaceuticals, Inc., Tarrytown, Cancer NY, 3University of Pittsburgh Medical Center NW, Pittsburgh, PA Dr. Erica T. Gastelum, MD , UCSF Fresno, Madera, CA, Kush 298 Asthma Management Costs With Feno In Addition To Standard Das, Baz Allergy, Asthma & Sinus Center, Fresno, CA, Dr. Praveen Guidelines Buddiga, MD, FAAAAI, University of California San Francisco- Dr. Glenn Crater, MD 1, Dr. Craig F. LaForce, MD, FAAAAI 2, Ms. Fresno, Fresno, CA; Baz Allergy Asthma & Sinus Center, Fresno, Nancy Herje, BSN, RN, MBA 1, Dr. Elizabeth , PhD 3 and Dr. CA and Dr. Malik N. Baz, MD, UCSF-Fresno, Fresno, CA; Baz Al- Kathy Rickard, M.D.1, 1Aerocrine, Inc., Morrisville, NC, 2North lergy Asthma and Sinus Center, Fresno, CA Carolina Clinical Research, Raleigh, NC, 3Reimbursement Princi- 305 IL-17 Plays a Major Role In Driving The Recruitment Of B ples, Highlands Ranch, CO Cells Into Bronchial Tissue Of Asthmatic Patients 299 Developmental Assessment Of Serum Periostin As An Asthma Dr. S Al-Muhsen, MD , King Saud University, College of Medi- Biomarker In Children cine, Riyadh, Saudi Arabia, Mrs. Mary -Angeline Pureza, King Dr. Halie M. Anderson 1, Dr. Robert F. Lemanske Jr., MD, Saud University, Riyadh, Saudi Arabia, Dr. Qutayba Hamid, MD, FAAAAI 2, Joseph R. Arron 3, Cecile Holweg 4, Ms. Victoria Raja- PhD, FAAAAI, McGill University Health Centre, Montreal, QC, manickam5, Dr. James E. Gern, MD, FAAAAI 2 and Dr. Daniel J. Canada and Dr. Rabih Halwani, PhD, King Saud University, college Jackson, MD 6, 1University of Wisconsin, Madison, WI, 2University of Medicine, Riyadh, Saudi Arabia SUNDAY of Wisconsin School of Medicine and Public Health, Madison, WI, 306 A Comparison Of Asthma Prevalence and Severity Among Ur- 3Genentech, Inc., South San Francisco, CA, 4Genentech, Inc, South ban and Rural African American Teenage Youth San Francisco, CA, 5University of Wisconsin Hospitals and Clinics, Dr. Dennis Ownby, M.D. FAAAAI 1, Dr. Martha Tingen, PhD 2, 6Pediatrics, University of Wisconsin School of Medicine and Public Ms. Suzanne Havstad, M.A. 3, Dr. Jennifer Waller, PhD 2, Dr. Chris- Health, Madison, WI tine Cole Johnson, PhD MPH FAAAAI 3 and Dr. Christine L.M. Jo- seph, PhD3, 1Division of Allergy-Immunology and Rheumatology, Georgia Health Sciences University, Augusta, GA, 2Georgia Re- gents University, Augusta, GA, 3Department of Public Health Sci- ences, Henry Ford Hospital, Detroit, MI Atopic Disease Basic Science 307 Interleukin-4 and Transforming Growth Factor-Beta Single Nu- cleotide Genes Polymorphisms Confer Susceptibility To Atopic 3203 Dermatitis Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Dr. Nima Rezaei, MD, PhD 1,2, Ms. Zahra Aryan 2,3, Dr. Nasrin 300 T-Cell Profiles In Bronchoalveolar Lavage (BAL) Of Wheezing Behniafard, MD 4, Ms. Elham Farhadi, MSc 5, Dr. Soheila Sotoudeh, Children With and Without A History Of Respiratory Syncytial MD 4, Dr. Mojdeh Khaledi, MD 6, Dr. Maryam Mahmoudi, MD 7, Virus (RSV) Lower Respiratory Tract Infection Prof. Asghar Aghamohammadi8, Prof. Ali Akbar Amirzargar, Dr. Chang-Kuen Kim, MD, FAAAAI , Asthma & Allergy Center, PhD2 and Dr. Mohammad Gharagozlou, MD 4, 1Research Center Inje University Sanggye Paik Hospital, Seoul, South Korea, Dr. Jin- for Immunodeficiencies, Children’s Medical Center, Tehran Univer- Tack Kim, MD, PhD, Department of Pediatrics, Uijeongbu St. sity of Medical Sciences, Tehran, Tehran, Iran, 2Molecular Immu- Mary’s Hospital, The Catholic University of Korea, College of nology Research Center; and Department of Immunology, School Medicine, Uijeongbu, Gyeonggi-Do, South Korea, Sally E. Wenzel, of Medicine, Tehran University of Medical Sciences, Tehran, MD, FAAAAI, University of Pittsburgh Medical Center NW, Pitts- Iran, 3Student Scientific Research Center (SSRC), School of Med- burgh, PA and Dr. Marzena E. Krawiec, MD, National Jewish Med- icine, Tehran University of Medical Sciences, Tehran, Iran, 4Chil- ical and Research Center, Denver, CO dren’s Medical Center, Tehran University of Medical Sciences, 301 Increased Blood Th2-Like Invariant Natural Killer T Cells In Tehran, Tehran, Iran, 5Hematology Department, School of Allied Patients With Asthma Medical Science, Tehran University of Medical Sciences, Tehran, Prof. Young-Il Koh, MD and Jae-Uoong Shim, Chonnam National Tehran, Iran, 6Growth and Development Research Center, Tehran University Medical School University of Medical Sciences, Tehran, Tehran, Iran, 7School of 302 Establishment and Treatment Of a Steroid Resistant Asthma Nutrition and Dietetics, Tehran University of Medical Sciences, Model By Adoptive Transfer Of Helper T Cell Clones Tehran, Tehran, Iran, 8Research Center for Immunodeficiencies, Dr. Akio Mori, MD, PhD 1, Mr. Satoshi Kouyama, MSc 1, Ms. Children’s Medical Center, Tehran University of Medical Sciences, Miyako Yamaguchi 1, Ms. Yo Iijima 1, Dr. Jun Itoh, MD 1, Dr. Hir- Tehran, Iran oaki Hayashi, MD 1, Dr. Takafumi Minami, MD 1, Dr. Kentaro Wa- 308 A Comparison Of Regulatory T-Cell Receptor V b (3,5) Expres- tarai, MD 1, Dr. Chihiro Mitsui, MD 1, Dr. Chiyako Oshikata, MD 1, sion In Patients With Food Allergy and Atopic Dermatitis Dr. Hidenori Tanimoto, MD 1, Dr. Yuma Fukutomi, MD 1, Dr. Benjamin Prince, MD 1,2, Kristin A. Erickson 1, Christine Szychlin- Kiyoshi Sekiya, MD 1, Dr. Takahiro Tsuburai, MD, PhD 1, Dr. Ma- ski, APN, CPNP2, Miao Cai, MS 2 and Dr. Anne Marie Singh, sami Taniguchi, MD, PhD 1, Dr. Yuji Maeda, MD 1, Dr. Mamoru Oh- MD 1,3, 1Northwestern University Feinberg School of Medicine, tomo, MD 1, Dr. Maki Hasegawa, MD, PhD 1, Dr. Kazuo Akiyama, Chicago, IL, 2Division of Allergy & Immunology, Ann & Robert

103 AB314 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Division of 317 17 b-Estradiol Increases IL-17A Protein Expression From Allergy & Immunology, Department of Pediatrics, Northwestern Mouse CD4+ Th17 Differentiated Cells University Feinberg School of Medicine, Ann & Robert H. Lurie Jacqueline-Yvonne Cephus, BS 1, Dr. Dawn C. Newcomb Baker, Children’s Hospital of Chicago, Chicago, IL PhD2, Madison Boswell 1, Kasia Goleniewska 3 and Dr. Ray Peebles, 309 Correlation Between Fractional Exhaled Nitric Oxide and MD 1, 1Allergy, Pulmonary, and Critical Care Medicine; Depart- Asthma Exacerbation ment of Medicine; Vanderbilt University School of Medicine, Nash- Dr. Nawinda Mahawichit, MD , Mahidol University, Bangkok, ville, TN, 2Division of Allergy, Pulmonary and Critical Care Thailand Medicine, Vanderbilt University School of Medicine, Nashville, 310 IL17RB+ Granulocytes In Asthma Patients TN, Nashville, TN, 3Allergy, Pulmonary, and Critical Care Medi- Dr. Lin Li, MD 1, Dr. Matthew A. Schaller, PhD 2, Dr. Alan P. Bap- cine, Department of Medicine, Vanderbilt University School of tist, MD, MPH FAAAAI 1 and Dr. Nicholas W. Lukacs, PhD 3, 1Uni- Medicine, Nashville, TN versity of Michigan, Division of Allergy and Clinical Immunology, 318 17-b Estradiol Positively Correlates With IL-17A+ CCR6+ Ann Arbor, MI, 2University of Michigan, Department of Pathology, Memory CD4+ T Cells In Patients With Severe Asthma Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI Dr. Dawn C. Newcomb Baker, PhD 1,2, Jacqueline-Yvonne Ce- 311 Pollen From Genetically Modified Bt Maize Does Not Promote phus, BS 3, Dr. Emily W. Langley, MD 4, Amy S. Feldman, MD 5, Allergic Responses In Mice Mrs. Nanalene Frey6, Ms. Kristen Cooper 6, Dr. John M. Fahren- Mrs. Monica Andreassen1,2, Dr. Elena Rocca 3, Dr. Thomas holz, MD, FAAAAI 7 and R. Stokes Peebles 8, 1Vanderbilt Univer- SUNDAY Bøhn3,4, Dr. Odd-Gunnar Wikmark 3, Prof. Johnnie Van den sity School of Medicine, Nashville, TN, 2Medicine, Vanderbilt Berg5, Prof. Martinus Lovik 2, Prof. Terje Traavik 3,4 and Dr. Unni University Medical Center, Nashville, TN, 3Allergy, Pulmonary, C. Nygaard 2, 1GenØk - Centre for Biosafety, Tromso, Norway, and Critical Care Medicine; Department of Medicine; Vanderbilt 2Norwegian Institute of Public Health, Oslo, Norway, 3GenØk - University School of Medicine, Nashville, TN, 4Division of Al- Centre for Biosafety, Norway, 4University of Tromsø, Norway, lergy, Pulmonary, and Critical Care Medicine, Department of Med- 5North-West University, Potchefstroom, South Africa icine, Vanderbilt University School of Medicine, Nashville, 312 Effects Of rs3744262 On DNA Methylation and Symptoms In Tennessee, 5Division of Allergy, Pulmonary, and Critical Care Med- Participants With Allergic Rhinitis During Grass Pollen Expo- icine, Department of Medicine, and Center for Asthma and Envi- sure In The Environmental Exposure Unit (EEU) ronmental Sciences Research, Vanderbilt University School of Dr. Michelle North, PhD 1, Ms. Sarah Mah, BSc. 2, Mr. Andrew G. Medicine, Nashville, TN, 6Vanderbilt University Medical Center, Day, MSc 3, Dr. Michael Kobor, PhD 2,4 and Dr. Anne K. Ellis, MD, 7Vanderbilt University Medical Center, Nashville, TN, 8Allergy, MSc FAAAAI 1,5, 1Departments of Medicine and Biomedical & Pulmonary, and Critical Care Medicine, Department of Medicine, Molecular Science, Queen’s University, Kingston, ON, Canada, Vanderbilt University School of Medicine, Nashville, TN 2Centre for Molecular Medicine & Therapeutics, Child & Family 319 Allergic Sensitization and Determination Of Serum Eosinophil Research Institute, Vancouver, BC, Canada, 3Clinical Research Cationic Protein and Triptase In Preschool Population In Her- Centre, Kingston General Hospital, Kingston, ON, Canada, 4Uni- mosillo, Sonora, Mexico versity of British Columbia, Vancouver, BC, Canada, 5Allergy Re- Dr. Claudia Gallego-Corella 1, Dr. Guadalupe Corella 2, Ms. An- search Unit, Kingston General Hospital, Kingston, ON, Canada drea Romo3, Prof. Antonio Rasc on 4 and Mr. Pablo Mart ınez3, 313 Chronic Spontaneous Urticaria – An Evaluation Of An Indirect 1Medicine Faculty, Xochicalco University, Tijuana, Mexico, Immunofluorescence Method For Detecting Anti-Mast Cell IgG 2Health, Nutrition and Environment, Department of Chemical and Antibodies Biological Sciences, University of Sonora, Mexico, Hermosillo, Bahar Bahrani, Natasha Gattey and Peter Hull, University of Sas- Mexico, 3Department of Chemical and Biological Sciences, Univer- katchewan, Canada sity of Sonora, Mexico, Hermosillo, Mexico, 4Health, Nutrition and 314 Protease Activity Of Per a 10 Causes CD 40 Cleavage On Den- Environment, Department of Chemical and Biological Sciences,U- dritic Cells and Th2 Polarization niversity of Sonora, Mexico, Hermosillo, Mexico Ms. Komal Agrawal, MSc , CSIR-IGIB, DELHI, and Dr. 320 Fungal Cross-Allergenicity In Specific Ige Testing Naveen Arora, Ph.D, CSIR Institute of Genomics and Integrative Dr. Mercedes C. Amado, MD, FAAAAI 1, Dr. Jay M. Portnoy, Biology, New Delhi, India MD, FAAAAI 2 and Dr. Charles Barnes, PhD 2, 1Children’s Mercy 315 Type 2 Immunity Can Have a Protective Role In Host Defense Hospital, Shawnee Mission, KS, 2Children’s Mercy Hospital, Kan- Against Venoms In Mice sas City, MO Dr. Thomas Marichal, DVM PhD 1, Dr. Philipp Starkl, PhD 1, Dr. 321 Monocytes From Peanut-Allergic Patients Express Higher Laurent Reber, PhD 1, Dr. Janet Kalesnikoff, PhD 1, Dr. Hans C. Levels Of RALDH2 In Response To Peanut Protein Than Mon- Oettgen, MD, PhD, FAAAAI 2, Dr. Mindy Tsai, DMSc 1, Dr. Martin ocytes From Tolerant Subjects Metz, MD, PhD3 and Dr. Stephen J. Galli, MD 1, 1Stanford Univer- Elizabeth Fleming, BS 1, Bert Ruiter, PhD 1, Barry K. Hurlburt, sity School of Medicine, Stanford, CA, 2Boston Children’s Hospi- PhD2, Soheila J. Maleki, PhD 2 and Wayne G. Shreffler, MD, tal, Boston, MA, 3Charite Campus Mitte, Berlin, Germany PhD, FAAAAI 1, 1Massachusetts General Hospital, Boston, MA, 316 CD4+ and CD8+ T Cells Bearing Na €ıve and Memory Markers 2USDA-ARS-SRRC, New Orleans, LA In Blood Of Immigrants To Brooklyn Who Develop Asthma and 322 Peanut Protein Induces Expression Of RALDH2 In Human Allergic Disease Dendritic Cells In a TLR2-Dependent Manner Dr. Ashlei Mathew, MD 1,2, Dr. Irina Katayeva, MD 1,3, Seto Chice, Bert Ruiter, PhD 1, Elizabeth Fleming, BS 1, Barry K. Hurlburt, MS 1,4, Dr. Stephan Kohlhoff, MD 1,5, Dr. Rauno O. Joks, MD, PhD2, Soheila J. Maleki, PhD 2 and Wayne G. Shreffler, MD, FAAAAI 1,2, Dr. Helen G. Durkin, PhD 1,4 and Dr. Maria-Anna Vast- PhD, FAAAAI 1, 1Massachusetts General Hospital, Boston, MA, ardi, MD 1,3, 1Center for Allergy and Asthma Research, State Uni- 2USDA-ARS-SRRC, New Orleans, LA versity of New York Downstate Medical Center, Brooklyn, NY, 323 IL-4 Receptor Alpha and STAT6 Single Nucleotide Polymor- 2Department of Medicine, State University of New York Downstate phisms Are Associated With Increased Risk Of Asthma In a Medical Center, Brooklyn, NY, 3Lutheran Medical Center, Brook- Saudi Arabian Population lyn, NY, 4Department of Pathology, State University of New York Dr. Rabih Halwani, PhD 1, Dr. Alejandro Vazquez-Tello 2, Mr. Amer Downstate Medical Center, Brooklyn, NY, 5Department of Pediat- Jamhawi 2, Dr. Hamdan Jahdali 3 and Dr. Saleh Al-Muhsen, MD 4, rics, State University of New York Downstate Medical Center, 1King Saud University, college of Medicine, Riyadh, Saudi Arabia, Brooklyn, NY 2King Saud University, Riyadh, Saudi Arabia, 3King Saud University

104 J ALLERGY CLIN IMMUNOL Abstracts AB315 VOLUME 133, NUMBER 2

for Health Sciences, Riyadh, Saudi Arabia, 4King Saud University, Immunology, Department of Pediatrics, David Geffen School of College of Medicine, Riyadh, Saudi Arabia Medicine at UCLA, Los Angeles, CA, 3UCLA, CA 332 Studies On Cohort Of Infants With Di-George Syndrome De- tected By New York State Newborn Screening For Severe Com- bined Immunodeficiency (SCID) Dr. Doerthe A. Andreae, MD 1, Dr. Stephanie Albin, MD 1, Dr. T Cell Mediated Immunity Harshna Mehta, MD 1 and Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI 2, 1The Icahn School of Medicine at Mount Si- 3204 nai, New York, NY, 2Mt. Sinai Medical Center, New York, NY Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM 333 Immunologic Profile Of Single Ventricle Survivorship Partici- 324 Infants With Idiopathic T Cell Lymphopenia Identified On New pants: Risk Factors For Clinically Significant Immunologic York State Newborn Screen: A Follow Up Report Dysfunction Dr. Stephanie Albin, MD 1, Dr. Harshna Mehta, MD 1 and Dr. Char- Dr. Megan Morsheimer, MD, MPH , Dr. Jack Rychik, MD, FACC, lotte Cunningham-Rundles, MD, PhD, FAAAAI 2, 1The Icahn Ms. Katie Dodds, RN, MSN, CRNP and Dr. Jennifer Heimall, MD, School of Medicine at Mount Sinai, New York, NY, 2Mt. Sinai Children’s Hospital of Philadelphia, Philadelphia, PA Medical Center, New York, NY 334 Chronic Non-Iatrogenic Lymphatic Loss Syndromes Identified 325 Frequency Of Cellular and Humoral Immunodeficiencies In Di- Though Abnormal TREC Analysis From The Texas Newborn george Syndrome Patients Seen At New York Presbyterian Co- Screening Program (NBS) lumbia Between 2006-2012 Dr. Qurat U. Kamili, MD 1, Niti Y. Chokshi, MD 2, Dr. Jordan Or- Dr. Collette Spalding, MD 1, Dr. Kyung Hwa Jung, PhD 1, Dr. Ra- ange, MD, PhD, FAAAAI 3, Dr. I. Celine Hanson, MD, FAAAAI 4 chel L. Miller, MD, FAAAAI 1 and Dr. Yesim Demirdag, MD 2, 1Di- and Dr. Lisa R. Forbes, MD 4, 1Baylor College of Medicine and Texas vision of Pulmonary, Allergy and Critical Care Medicine, Columbia Children’s Hospital, Section of Immunology, Allergy and Rheuma- University, New York, NY, 2Department of Pediatric Allergy/Im- tology, Houston, TX, 2Baylor College of Medicine and Texas Chil- munology, Columbia University, New York, NY dren’s Hospital, Section of Immunology, Allergy and 326 A Novel ORAI1 Mutation Resulting In T +B+NK + SCID With Rheumatology, Houston, TX, 3Baylor College of Medicine and Texas Normal Lymphocyte Proliferation Children’s Hospital, Section of Immunology, Allergy and Rheuma- Janet S. Chou, MD 1, Christina S.K. Yee, MD, PhD 1, Mr. Wayne tology, 4Baylor College of Medicine-Texas Children’s Hospital, Sec- Bainter, BS 1, Dr. Luigi D. Notarangelo, M.D. 2, Dr. Suleiman M. tion of Immunology, Allergy, and Rheumatology, Houston, TX 3 1 1 335 An Adult With Disseminated Herpes Zoster Infection Found To S. E. Al-Hammadi, MD, FAAAAI and Raif S. Geha, MD , Divi- SUNDAY sion of Immunology, Boston Children’s Hospital, Harvard Medical Have Rare Combined CD4, CD8 T-Cell and NK-Cell Deficiency School, Boston, MA, 2Stem Cell Institute, Boston, MA, 3FMHS, Neil Parikh, MD , UCLA-VA Greater Los Angeles Healthcare Sys- UAE University, Al-Ain, United Arab Emirates tem, Los Angeles, CA and Joseph S. Yusin, MD, FAAAAI, VA 327 Coronin-1A Oligomerization Is Critical For Host Defense Greater Los Angeles Health Care System, Los Angeles, CA Against Viral Pathogens 336 Clinical and Virological Characteristics Of HIV-Associated Christina S.K. Yee, MD, PhD 1, Ozden Sanal, MD 2, Janet S. Chou, In Patients With Perinatally-Acquired HIV In MD 1, Raif S. Geha, MD 1, Deniz Ayvaz, MD 3, Caner Aytekin, MD 3 The Era Of Antiretroviral Therapy and A. Nurten Akarsu, MD, PhD 4, 1Division of Immunology, Boston Dr. Jasmeen S. Dara, MD , Montefiore Medical Center/Albert Ein- Children’s Hospital, Harvard Medical School, Boston, MA, 2Depart- stein College of Medicine, Dr. Stefan Barta, Montefiore Medical ment of Pediatrics, Hacettepe University Ihsan Dogramaci Children’s Center and Dr. Jenny Shliozberg, MD, FAAAAI, Montefiore Med- Hospital, Ankara, Turkey, 3Department of Pediatric Immunology, Dr ical Center, Bronx, NY Sami Ulus Maternity and Children’s Research and Educational Hos- pital, Ankara, Turkey, 4Department of Medical Genetics, Hacettepe University Ihsan Dogramaci Children’s Hospital, Ankara, Turkey 328 Newborn Screening For Severe Combined Immunodeficiency In Asthma Epidemiology, Risk Factors and Public Iowa: TREC Assay Results and Characteristics Of SCID and T- Cell Lymphopenic Patients Health II Farheen Mirza, MD 1, Emily Phillips, RN BSN CCRC 1, Travis Henry, PhD 1 and Dr. Mary Beth Fasano, MD, FAAAAI 2, 1Univer- 3205 sity of Iowa, 2C42-E6 GH, University of Iowa College Medicine, Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Iowa City, IA 337 Study On Air Pollution and Respiratory Health Of Children In 329 Thymus Graft Factors Critical For Negative Selection Of Direct Delhi, India Allospecific T Cells Ms. Jincy Mathew, M.Tech , CSIR- Institute of Genomics and In- Dr. Ivan K. Chinn, MD , Dr. Ivo D. Shterev, PhD, Kristina J. Riebe tegrative Biology, Delhi, India, Dr. Radha Goyal, Ph.D, CSIR- Na- and Dr. Douglas C. Rouse, DVM, Duke University Medical Center, tional Environmental Engineering Research Institute, Delhi, India, Durham, NC Dr. Krinshna K Taneja, Ph.D, CSIR- Istitute of Genomics and Inte- 330 Successful Hematopoietic Stem Cell Transplant For CD40 Defi- grative Biology,, Delhi, India and Dr. Naveen Arora, Ph.D, CSIR ciency Manifesting As Hyper-IgM Syndrome With Absent Institute of Genomics and Integrative Biology, New Delhi, India CD40 Expression and Marked Lymphocytosis 338 Trans-Generational Transmission Of Ozone – Induced Airway Dr. Joyce Hsu, MD , Medicine, Boston Children’s Hospital, Boston, Dysfunction MA, Dr. Michel Massaad, PhD, Boston Children’s Hospital and Dr. Prof. Park Choon Sik , Mr. Bae Da-Jeong, Dr. Park Jong-Sook and Luigi D. Notarangelo, MD, Stem Cell Institute, Boston, MA Dr. Jang An Soo, Soonchunhyang University Bucheon Hospital, 331 IL-2 Receptor Gamma-Chain(IL2RG) Defect Can Present With Gyeonggi-Do, South Korea Features Other Than Increased Susceptibility To Infection 339 Dust Mite Allergen In Bed Dust Predicts Rhinitis Symptom Per- Dr. Bob Geng, MD 1, Dr. Maria Garcia-Lloret, MD, FAAAAI 2, Dr. sistence In Urban Pre-Adolescent Children With Higher Ele- Yen Tun Wang, MD 3, Dr. Ki-Young Yoo, MD 3, Dr. Raymond Barn- mental Carbon Particulate Matter Exposure hill, MD 3, Dr. Derek Wong, MD 3 and Dr. E. Richard Stiehm, MD, Dr. Young Yoo, MD, PhD 1,2, Dr. Luis M. Acosta, MD 1, Prof. Inge FAAAAI 2, 1UCLA, Los Angeles, CA, 2Division of Allergy and Goldstein, DrPH3, Prof. Andrew Rundle, DrPH 4, Omar Olmedo 1,

105 AB316 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Adnan Divjan 1, Dr. Beihzhan Yan 5, Prof. Judith Jacobson, DrPH 4, 347 IgE Antibodies To Cat and Cat Components In Relation To Dr. Rachel L. Miller, MD, FAAAAI 6, Dr. Steven Chillrud 5 and Asthma In a Population Study Of 963 18 Year Olds From Six Prof. Matthew S. Perzanowski, PhD 1, 1Department of Environmen- Schools In Northern Sweden tal Health Sciences, Mailman School of Public Health, Columbia Ms. Hayley James, BS 1, Prof. Matthew S. Perzanowski, PhD 2, Eva University, New York, NY, 2Department of Pediatrics, College of Ronmark, PhD3, Bo Lundback, MD, PhD 3, Jillian Roper 1 and Medicine, Korea University, Seoul, South Korea, 3Department of Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 4, 1University of Vir- Epidemiology, Mailman School of Public Health, Columbia Uni- ginia, Charlottesville, VA, 2Department of Environmental Health versity, New York, NY, 4Department of Epidemiology, Mailman Sciences, Mailman School of Public Health, Columbia University, School of Public Health, Columbia University, New York, NY, 5La- New York, NY, 3Karolinska Institutet, Stockholm, Sweden, 4Divi- mont-Doherty Earth Observatory, Columbia University, Palisades, sion of Asthma, Allergy & Immunology, University of Virginia NY, 6Division of Pulmonary, Allergy and Critical Care Medicine, Health System, Charlottesville, VA Columbia University, New York, NY 348 Epitope Mapping Of An Anti-Bla g 1 ScFv Used For Cockroach 340 Associations Between Outdoor Of PM2.5 With Cough and Allergen Quantitation Wheeze Symptoms In Asthmatic Children In Korea Dr. Geoffrey Mueller, PhD 1, Mr. John Ankney 2, Dr. Lars Peder- Prof. Woo Kyung Kim, MD, PhD 1,2, Mrs. Young Wook Lee 1 and sen1, Dr. Taruna Khurana, PhD 3, Dr. Jay E. Slater, MD 4, Ms. Jill Dr. Hae-Sun Yoon 1, 1Allergy & respiratory research laboratory, Inje Glesner5, Dr. Anna Pomes, PhD FAAAAI 5 and Dr. Robert London 1, University College of Medicine, Seoul, South Korea, 2Department 1National Institute of Environmental Health Sciences, NIH, Re- SUNDAY of Pediatrics, Seoul Paik Hospital, Inje University College of Med- search Triangle Park, NC, 2National Intstitute of Environmental icine, Seoul, South Korea Health Sciences, NIH, 3FDA Center for Biologics Evaluation and 341 Effect Of Duration Of Residence In Brooklyn On IgE Re- Research, 4FDA/CBER/OVRR/DBPAP, Rockville, MD, 5Indoor Bi- sponses Of Immigrants otechnologies, Inc., Charlottesville, VA Dr. Edward Kleiman, MD 1, Dr. Maria-Anna Vastardi, MD 2,3, Dr. 349 Antigenic Analysis Of The Major Cockroach Allergen Bla g 5 Irina Katayeva, MD 2,3, Dr. Helen G. Durkin, PhD 2 and Dr. Rauno and Its Dust Mite Homolog Der p 8 O. Joks, MD, FAAAAI 1, 1SUNY Downstate Medical Center, Center Ms. Jill Glesner1, Dr. Geoffrey Mueller, PhD 2, Dr. Lars Pedersen 2, for Allergy and Asthma Research, Brooklyn, NY, 2Center for Allergy Dr. Martin D. Chapman, PhD FAAAAI 1 and Dr. Anna Pomes, PhD and Asthma Research, State University of New YorkDownstate Med- FAAAAI 1, 1Indoor Biotechnologies, Inc., Charlottesville, VA, 2Na- ical Center, Brooklyn, NY, 3Lutheran Medical Center, Brooklyn, NY tional Institute of Environmental Health Sciences, NIH, Research 342 Impact Of Energy Expenditure On Ozone-Induced Inflamma- Triangle Park, NC tion 350 Immunomodulatory Effects Of Rye Grass Pollen Allergen Lol p 1 1 Dr. Krista Todoric, MD , Dr. Michelle L. Hernandez, MD , Dr. 5 On The Prostaglandin E 2 Pathway and Kallikrein-Kinin Sys- Haibo Zhou, PhD2 and Dr. David B. Peden, MD, MS, FAAAAI 1, tem Of Respiratory Epithelial Cells 1University of North Carolina at Chapel Hill School of Medicine, Cecilia Tong , Alice Vrielink, Martha Ludwig and Geoffrey Stew- Chapel Hill, NC, 2University of North Carolina at Chapel Hill, art, University of Western Australia School of Public Health 351 Development and Characterization Of a Murine Model Of Re- 343 Exposure Of Mice To Silica Crystals and Poly I:C Synergisti- peated Dry Exposure To Aerosolized Fungal Conidia cally Enhances Neutrophil Infiltration and Epithelial Damage Dr. Ajay Nayak, PhD 1, Dr. Amanda Buskirk, PhD 1,2, Mr. W.Travis In The Airway Goldsmith3, Ms. Angela Lemons 1, Dr. Justin Hettick, PhD 1, Dr. Mi- Dr. Hirotoshi Unno, M.D. , Dr. Hideaki Morita, MD., PhD., Dr. Hir- chael Kashon, PhD 4, Ms. Amy Cumpston 3, Mr. Jared Cumpston 3, ohisa Saito, MD., PhD., Dr. Kenji Matsumoto, MD, PhD and Dr. Akio Mr. Howard Leonard 3, Mr. Walter McKinney 3, Dr. David Frazer, Matsuda, PhD, Department of Allergy and Immunology, National PhD3, Dr. Donald H. Beezhold, PhD FAAAAI 1 and Dr. Brett J. Research Institute for Child Health and Development, Tokyo, Japan Green, PhD1, 1CDC/NIOSH/ACIB, Morgantown, WV, 2West Vir- 344 Modest Effects Of Bisphenol A Exposure In Mouse Models Of ginia University, Morgantown, WV, 3CDC/NIOSH/PPRB, Morgan- Respiratory Allergy and Food Allergy town, WV, 4CDC/NIOSH/BEB, Morgantown, WV Dr. Unni C. Nygaard 1, Dr. Mari Samuelsen 1, Dr. Nina Vinje 1, Mrs. 352 Cross-Reactivity Between Recombinant Tropomyosin From Monica Andreassen1,2, Prof. Martinus Lovik 1 and Dr. Johanna Chortoglyphus and Natural Tropomyosin Of Other Extracts Bodin1, 1Norwegian Institute of Public Health, Oslo, Norway, Dr. Jer onimo Carn es 1, Dr. M. Angeles L opez Matas1, Dr. Manuel 2GenØk - Centre for Biosafety, Tromso, Norway Boquete, MD 2, Dr. Raquel Moya 1 and Dr. Victor Miguel Iraola 1, 1Laboratorios LETI, Tres Cantos, Spain, 2Hospital Xeral de Calde, Lugo, Spain 353 Identification Of The Cysteine Protease Amb a x As A Novel Major Allergen From Short Ragweed Pollen (Ambrosia artemi- Aerobiology II siifolia) Dr. Philippe Moingeon, PhD 1, Julien Bouley, PhD 2, Maxime Le 3206 Mignon, PhD 2, V eronique Baron-Bodo, PhD 2, V eronique Bordas, Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM PhD 2, Laetitia Bussi eres 2, Marie-No €elle Couret 3, Aur elie Lautr- 345 In Vitro Allergy Testing: Relationship Patterns Between Aller- ette, PhD 2, Thierry Batard, PhD 4, Rachel Groeme 2, Henri Chabre, gen Pairs PhD 2 and Emmanuel Nony 2, 1Stallergenes SA, Antony, France, Dr. John S. Kaptein, PhD 1, C.K. Lin, PhD 1 and Dr. Bruce J. Gold- 2Stallergenes, France, 3Stallergenes, 4Stallergenes, Antony, berg, MD, PhD, FAAAAI 2, 1Southern California Permanente France Medical Group, Los Angeles, CA, 2Kaiser Permanente, Los An- 354 Characterization Of The Allergenic Activity Of Tropomyosin geles, CA From Aedes Aegypti 346 Comparison Of Total Protein Profile Of Alternaria Alternata Mr. Jose F. Cantillo , Complutense University of Madrid, Spain; In- Extract Obtained From Various U.S. Allergenic Extract Manu- munotek S.L., Alcala de Henares, Spain, Prof. Leonardo Puerta, In- facturers stitute for Immunological Research/University of Cartagena, Dr. Jay E. Slater, MD 1, Ms. Allison Zoch 2, Ms. Shoshana New- Cartagena, Colombia, Dr. Enrique Fernandez-Caldas, Inmunotek, man-Gerhardt2 and Dr. Taruna Khurana, PhD 3, 1FDA/CBER/ S.L, Spain and Dr. Sylvie Lafosse-Marin, Cabinet de Inmunoaller- OVRR/DBPAP, Rockville, MD, 2FDA/CBER, 3CBER FDA gology, Fort de France, Martinique

106 J ALLERGY CLIN IMMUNOL Abstracts AB317 VOLUME 133, NUMBER 2

355 Allergy To Ferret Kamilaris, RN 3, Michael D. Kulis Jr., PhD 1, Jelena Berglund, PhD, Mr. Ignacio Esteban Gorgojo 1, Javier Cuesta Herranz 1, Carlos RAC 2 and A. Wesley Burks, MD, FAAAAI 1, 1University of North Pastor2, Aroa Sanz Maroto 2, Mr. David Gonzalez 3 and Dr. Manuel Carolina, Chapel Hill, NC, 2Duke University, Durham, NC, 3Caro- De Las Heras 1, 1Department of Allergy, Fundaci on Jim enez Dıaz, linas Health Care System, Charlotte, NC Madrid, Spain, 2Department of Immunology, Fundaci on Jim enez 364 Single Practice Five-Year Experience Treating Food Allergy Dıaz, Spain, 3Allergy unit, Hospital de Fuenlabrada, Spain With Oral Immunotherapy: Efficacy and Epinephrine Treated 356 Do Residual Wheal Skin Prick Test Responses To Perennial and Reactions Seasonal Allergens Correlate With Their Specific IgE Levels In Mrs. Angela R. Hague, PA-C , Dr. Richard L. Wasserman, MD, Allergic Subjects? PhD, FAAAAI, Dr. Stacy K. Silvers, MD and Dr. Robert W. Suger- Dr. AnneMarie Salapatek, PhD , Victoria Nelson, M.Sc and Dr. man, MD, FAAAAI, DallasAllergyImmunology, Dallas, TX Piyush Patel, MD, FRCP, Inflamax Research, Mississauga, ON, 365 Single Practice, Five-Year Experience Treating Food Allergy Canada With Oral Immunotherapy (FOIT): Successes and Failures Ms. Dena M. Pence, RT , Mrs. Angela R. Hague, PA-C, Dr. Ri- chard L. Wasserman, MD, PhD, FAAAAI, Dr. Robert W. Suger- Food Allergy I man, MD, FAAAAI and Dr. Stacy K. Silvers, MD, DallasAllergyImmunology, Dallas, TX 3207 366 Single Practice Five Year Experience Treating Food Allergy Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM With Oral Immunotherapy (FOIT): Effect On Antigen Specific 357 Peanut Epicutaneous Immunotherapy (EPIT) In Peanut-Aller- IgE (asIgE) gic Children: 18 Months Treatment In The Arachild Study Dr. Stacy K. Silvers, MD , Mrs. Angela R. Hague, PA-C, Ms. Dena Prof. Christophe Dupont, MD, PhD 1, Dr. Thierry Bourrier 2, Prof. M. Pence, RT, Dr. Robert W. Sugerman, MD, FAAAAI and Dr. Ri- Frederic de BLAY 3, Dr. Lydie Gu enard-Bilbault3, Dr. Christine chard L. Wasserman, MD, PhD, FAAAAI, DallasAllergyImmunol- Sauvage4, Dr. Marie-Odile Cousin 4, Dr. Gis ele Kanny, MD, ogy, Dallas, TX PhD5, Dr. Sophie Jarlot 5 and Dr. Chantal Karila, MD 6, 1Hopital 367 Secondary Eosinophilic Reactions During ORAL Immunother- Necker Enfants Malades, Paris, France, 2Lenval Hospital, Nice, apy France, 3CHRU Strasbourg, France, 4Saint Vincent de Paul Hospi- Prof. Yitzhak Katz, MD, FAAAAI 1,2, Dr. Michael Goldberg, MD, tal, Lille, France, 5CHU Nancy Hopital Central, Nancy, France, PhD2, Dr. Liat Nachshon, MD 2, Dr. Marc E. Rothenberg, MD, 6Hopital Necker, Paris, France PhD, FAAAAI 3,4, Dr. Miguel Leon Stein, MD, FAAAAI 5, Dr. Efrat Broide6,7, Dr. Gratiana Hermann 6, Dr. Arnon Elizur, MD 1,2 and Dr. 358 Predictors For Allergic Symptoms During Build-Up and Main- SUNDAY tenance Phases Of Oral Immunotherapy To Peanut Michael B. Levy, MD, FAAAAI 2, 1Tel Aviv University, Tel Aviv, Is- Dr. Marie M. de Alwis, MD 1,2 , Dr. Jason Lee, MD, FAAAAI 1, Dr. rael, 2Assaf Harofeh, Zerifin, Israel, 3Cincinnati Children’s Hospital Mitchell R. Lester, MD, FAAAAI 1, Dr. Louis M. Mendelson, MD, Medical Center, Cincinnati, OH, 4Children’s Hospital Medical Cen- FAAAAI 1, Dr. Glenda Nouman, MD 1 and Dr. Jeffrey M. Factor, ter, Cincinnati, OH, 5Assaf Harofeh Medical Center, Rehovot, Israel, FAAAAI 1, 1New England Food Allergy Treatment Center, West Hart- 6Assaf Hrofeh Meducal center, Israel, 7Tel-Aviv university ford, CT, 2Connecticut Children’s Medical Center, Hartford, CT 368 Rate Of Anaphylaxis Caused By Oral Immunotherapy In Chil- 359 Quality Of Life With Sublingual Immunotherapy For Peanut dren With Cow’s Milk Allergy Nicole Leung 1, Yamini Virkud, MD, MA 2, Pamela H. Steele, MSN Prof. Giovanni B. Pajno, MD, FAAAAI 1, Dr. Giuseppe Crisa- CPNP AE-C 3, Janet S. Kamilaris, RN 4, Edwin Kim, MD, MS 5, Brian fulli1,2, Dr. Giuseppina Salzano 1,2, Dr. Roberta Vadal a1,2, Dr. Stefa- P. Vickery, MD, FAAAAI 3, Dr. Audrey Dunn Galvin 6 and A. Wesley nia Arasi1,2, Dr. Salvatore Barberi 3 and Dr. Lucia Caminiti 1,2, Burks, MD, FAAAAI 3, 1Duke University, 2Duke University, Durham, 1University of Messina, Messina, Italy, 2Dept of Pediatrics, Allergy NC, 3University of North Carolina, Chapel Hill, NC, 4Carolinas Health Unit, University of Messina, 3Pediatric Clinic, San Paolo Hospital, Care System, Charlotte, NC, 5University of North Carolina at Chapel University of Milan, Milan, Italy Hill, Chapel Hill, NC, 6University College Cork, Cork, Ireland 369 Long-Term Follow Up In Cow’s Milk Anaphylaxis After Suc- 360 Low Dose Maintenance Peanut Oral Immunotherapy Can Pro- cessful Rush Oral Immunotherapy duce Sustained Unresponsiveness Mrs. Paloma Poza-Guedes , Dr. Ruperto Gonz alez-Perez, Dr. In- Julia A. Cronin, MD , University of Virginia, Division of Asthma, maculada Sanchez-Machın, MD and Dr. Victor Matheu, MD, Hos- Allergy and Immunology, Charlottesville, VA, Julia Wisniewski, pital del Torax-Ofra, Sta Cruz de Tenerife, Spain MD, University of Virginia, Division of Pediatric Respiratory Med- 370 Milk Oral Immunotherapy. Standard Versus Personalized Pro- icine and Allergy, Charlottesville, VA and Scott P. Commins, MD, tocols: Efficiency and Safety PhD, University of Virginia Health System, Charlottesville, VA Alberto Alvarez-Perea, MD , Dr. Elena Alonso-Lebrero, PhD, Fer- 361 Increases In Peanut-Specific IgA1 and IgA2 During Peanut Im- nanda Freire, MD, Dr. Sonsoles Infante, MD, Victoria Fuentes- munotherapy Do Not Correlate With Clinical Tolerance Aparicio, MD and Lydia Zapatero, MD, Hospital Materno Infantil Adrienne L. Yancey 1, Michael D. Kulis Jr., PhD 1, Pamela H. Gregorio Maran~on, Pediatric Allergy Department, Madrid, Spain Steele, MSN CPNP AE-C1, Edwin Kim, MD, MS 1, Brian P. Vick- 371 Cross-Desensitization To Goat and Sheep Milk Protein In Cow’s ery, MD, FAAAAI 2 and A. Wesley Burks, MD, FAAAAI 1, 1Univer- Milk Protein Desensitized Patients sity of North Carolina School of Medicine, Chapel Hill, NC, Dr. Michael Levy, MD, FAAAAI 1, Dr. Liat Nachshon, MD 1, Dr. 2University of North Carolina, Chapel Hill, NC Michael Goldberg, MD, PhD 1, Dr. Arnon Elizur, MD 1,2 and Prof. 362 Peanut OIT-Induced IgG Suppresses Ex Vivo Activation Of Al- Yitzhak Katz, MD, FAAAAI 1,2, 1Assaf Harofeh, Zerifin, Israel, lergic Donor Basophils Via a Combination Of Antigen Intercep- 2Tel Aviv University, Tel Aviv, Israel tion and Receptor-Bound Inhibition 372 Long Term Follow Up Of Children Who Incorporated Exten- Caitlin Burk, Michael D. Kulis Jr., PhD, Edwin Kim, MD, MS, Brian sively Heated (baked milk) In The Diet P. Vickery, MD, FAAAAI and A. Wesley Burks, MD, FAAAAI, Uni- Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI 1, Mrs. Beth D. versity of North Carolina at Chapel Hill, Chapel Hill, NC Strong, RN CCRC 2, Ms. Diane Ananos 1 and Hugh A. Sampson, 363 Omalizumab Pretreatment Does Not Protect Against Peanut MD, FAAAAI 3, 1Icahn School of Medicine at Mount Sinai, New Oral Immunotherapy-Related Adverse Gastrointestinal Events York, NY, 2Icahn School of medicine at Mount Sinia, New York, Uyenphuong Le, MD 1, Yamini Virkud, MD, MA 2, Brian P. Vick- NY, 3Pediatrics, Icahn School of Medicine at Mount Sinai, New ery, MD, FAAAAI 1, Pamela H. Steele, MSN CPNP AE-C 1, Janet S. York, NY

107 AB318 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

373 Baked Milk Oral Immunotherapy For Severe IgE-Mediated 383 The Use Of The ISAC Mircroarray Platform In Food Allergic Cow’s Milk Protein (CMP) Allergic Patients: Interim Results Patients Dr. Michael Goldberg, MD, PhD 1, Dr. Liat Nachshon, MD 1, Dr. Jacob Daniel Kattan, MD 1, Gustavo Gimenez, BA 1, Jay A. Lie- Arnon Elizur, MD 2, Dr. Moshe Appel 3, Dr. Michael B. Levy, berman, MD 2 and Hugh A. Sampson, MD, FAAAAI 3, 1Icahn MD, FAAAAI 1 and Prof. Yitzhak Katz, MD, FAAAAI 1,2, 1Assaf School of Medicine at Mount Sinai, New York, NY, 2University Harofeh, Zerifin, Israel, 2Department of Pediatrics, Sackler School of Tennessee, Memphis, TN, 3Pediatrics, Icahn School of Medicine of Medicine, Tel Aviv, Israel, 3Assaf Harofeh, Israel at Mount Sinai, New York, NY 374 Progression Towards Increasing Tolerance To Less Extensively 384 IgE Antibodies To Ara h 2 and Ara h 6 By Immunocap ISAC Heat-Denatured Milk Products Distinguish Peanut Anaphylaxis Children From Asymptomatic Hugh A. Sampson, MD, FAAAAI 1, Dr. George N. Konstantinou, Peanut Sensitization MD, PhD, MSc2,3, Jacob Daniel Kattan, MD 4, Madhan Masilamani, Dr. Rumiko Shibata, MD, PhD 1, Dr. Youko Murakami, MD 1 and PhD4, Mrs. Beth D. Strong, RN CCRC 5, Mr. Tee Bahnson, BS, Dr. Hiroshi Odajima 2, 1Department of Pediatrics, Fukuoka National MPH6, Ms. Kaitie Fernandez 7 and Dr. Anna H. Nowak-Wegrzyn, Hospital, Fukuoka, Japan, 2Fukuoka National Hospital, Fukuoka, MD, FAAAAI 4, 1Pediatrics, Icahn School of Medicine at Mount Si- Japan nai, New York, NY, 2424 General Military Training Hospital, The- 385 Molecular Component Testing For Peanut Allergy Reactivity ssaloniki, Greece, 3First Pediatric Department, Aristotle University Differs Based On Age of Thessaloniki, Hippokration General Hospital, Thessaloniki, Dr. Michelle L. Altrich, PhD , Viracor-IBT Laboratories, Lee’s SUNDAY Greece, 4Icahn School of Medicine at Mount Sinai, New York, Summitt, MO NY, 5Icahn School of medicine at Mount Sinia, New York, NY, 386 CD-Sens and Component Resolved Diagnostics In Diagnosing 6Rho Federal Systems Division, Inc., Chapel Hill, NC, 7Rho Fed- Hazelnut Allergy eral Systems Division, Inc., Chapel Hill, NC, Chapel Hill, NC Dr. Josef Brandstr om,€ MD 1, Prof. Magnus Borres, Md, Phd, 375 Cow’s Milk Allergen Specific CD4+ T Cell Responses In Pa- FAAAAI 2, Prof. S. G. O. Johansson, MD, PhD, FAAAAI 3, Ms. Ag- tients With Persistent Cow’s Milk Allergy neta Jansson Roth1, Ms. Ann-Charlotte Sundqvist 1, Dr. Gunnar Dr. Fatima S. Khan, MD , Altru, Grand Forks, ND, Nupur Bhatna- Lilja, MD, PhD1, Dr. Anna Nopp, PhD 3 and Dr. Caroline Nilsson, gar, PhD, Benaroya Research Institute, Seattle, WA, Dr. David Rob- MD, PhD1, 1Department of Clinical Science and Education, inson, Virginia Mason Medical Center and William W. Kwok, PhD, Sodersjukhuset,€ Karolinska Institutet and SachsChildrens Hospital, Benaroya Research Institute at Virginia Mason, Seattle, WA Sodersjukhuset,€ Stockholm, Sweden, 2Department of Women s and 376 The Role Of Skin Prick Testing and Specific IgE To Boiled Ver- Childrens Health, Uppsala Univerisity, and Thermo Fisher Scien- sus Unheated Cow Milk In Cow Milk Allergic Children tific, Uppsala, Sweden, 3Department of Medicine, Clinical Immu- Dr. Anilkumar Katta, MD , Saint Louis University, Saint Louis, nology and Allergy Unit, Karolinska Institutet, Stockholm, Sweden MO, Dr. Julie Hong, MD, St. Louis University, Portland, OR and 387 Effect Of Oleic Acid On The Allergenic Properties Of Peanut Dr. Alan Knutsen, MD, FAAAAI, Saint Louis University School and Cashew Allergens of Medicine, Saint Louis, MO Si-Yin Chung, PhD 1, Christopher P. Mattison, PhD 1, Shawndrika 378 Comparing The Utility Of Skin Prick Testing Using Commer- Reed1, Dr. Richard L. Wasserman, MD, PhD, FAAAAI 2 and Wendy cial Extracts and Fresh Food In Diagnosing Peanut Allergy A. Desormeaux 1, 1USDA-ARS-SRRC, New Orleans, LA, 2Allergy/ Dr. Carah Santos, MD , Dr. Matthew Strand, PhD, Pearlanne Zelar- Immunology Research Center of North Texas, Dallas, TX ney, MS and David Mark Fleischer, MD, FAAAAI, National Jewish 388 Identification Of Conformational IgE Epitopes Of Ara h 2 and Health, Denver, CO Ara h 6 379 Variability Of Major Allergens In Commercially Available Pea- Dr. Xueni Chen , University of Colorado, Aurora, CO and Dr. Ste- nut Extracts For Skin Prick Testing phen C. Dreskin, MD, PhD, FAAAAI, University of Colorado Den- Dr. Yong Luo, MD, PhD , Dr. Vincent R. Bonagura, MD, FAAAAI ver, Aurora, CO and Dr. David Rosenthal, DO, Division of Allergy/Immunology, 389 Basophil Response To Storage Proteins and Oleosins From Sun- Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ flower Seed School of Medicine, Great Neck, NY Maria Luisa Macias1, Dr. Francisca G omez, MD, PhD2, Araceli 380 Ara h 2 and The Relative Risk Of Other Sensitizations Diaz3, Dr. Cristobalina Mayorga, PhD 1, Dr. Ana Aranda, PhD 1, Mi- Dr. James Thompson, Fellow-In-Training , ., Evans, GA, Dr. Dan- guel Gonzalez1, Dr. Natalia Blanca-L opez, MD, PhD4, Dr. Gabriela iel Duquette, PhD, UW La Crosse, La Crosse, WI and Dr. Brock Canto, MD, PhD4, Ms. Miriam Osorio 1, Dr. Maria Garrido, PhD 3, Williams, PhD, U. of Missouri Medical School, Olathe, KS Dr. Maria J Torres, MD, PhD 2 and Dr. Miguel Blanca, MD, 381 Variability Of Repeat Peanut Serum IgE Levels PhD2, 1Research Laboratory, Carlos Haya Hospital-FIMABIS, Tricia D. Lee, MD , Icahn School of Medicine at Mount Sinai, Ja- Malaga, Spain, 2Allergy Service, Carlos Haya Hospital, M alaga, cob Daniel Kattan, MD, Icahn School of Medicine at Mount Sinai, Spain, 3Plant Biotechnology Institute (UPM-INIA), Madrid, Spain, New York, NY, Dr. Manish Ramesh, MD, PhD, Mount Sinai School 4Allergy Service, Infanta Leonor Hospital, Madrid, Spain of Medicine, New York, NY and Dr. Julie Wang, MD, FAAAAI, 390 Utility Of Ovomucoid Specific IgE In Predicting Unheated Egg The Icahn School of Medicine at Mount Sinai, New York, NY Food Challenge Outcomes 382 Does Peanut Allergen Conjunctival Provocation Test Reflect Dr. Katherine S. Larabee, MD 1, Dr. William J. Sheehan, MD 2,3, Specific IgE Levels To Peanut? Dr. Lisa M. Bartnikas, MD 2,3, Mr. Carter Petty, MA 3, Dr. Lynda Helene Lindvik, MD 1, Petter Mowinckel, M.Sc. 2, Jesintha Navar- C. Schneider, MD, FAAAAI 2,3 and Dr. Wanda Phipatanakul, MD, atnam, MD 3, Prof. Karin Cecilie Lødrup Carlsen, MD, PhD 1,4, Prof. MS, FAAAAI 2,3, 1Massachusetts General Hospital for Children, Magnus Borres, Md, Phd, FAAAAI 5, Dr. Bente Kvenshagen, MD 2 Boston, MA, 2Harvard Medical School, Boston, MA, 3Boston Chil- and Prof. Kai Hakon Carlsen, MD, PhD1,4, 1Department of Paedi- dren’s Hospital, Boston, MA atrics, Oslo University Hospital, Oslo, Norway, 2Oslo University 391 Allergy Testing In Childhood: Agreement Between Skin Prick Hospital, Oslo, Norway, 3Department of Ophthalmology, Oslo Uni- Test and Specific IgE In Preschool Children versity Hospital, Oslo, Norway, 4The Faculty of Medicine, Univer- Ann-Marie M. Schoos, MD , Bo Chawes, MD, Nilofar Følsgaard, sity of Oslo, Oslo, Norway, 5Department of Women s and Children s MD, Nasim Samandari, MD, Klaus Bønnelykke, MD and Dr. Hans Health, Uppsala Univerisity, and Thermo Fisher Scientific, Uppsala, Bisgaard, MD DMSci, Danish Pediatric Asthma Center, Gentofte, Sweden Denmark

108 J ALLERGY CLIN IMMUNOL Abstracts AB319 VOLUME 133, NUMBER 2

392 Measurement Of Allergenic Components For Predicting Clin- 400 The Relationship Between Mitochondrial Haplogroups Variant ically Relevant Shrimp Allergy In House Dust Mite Sensitized on Children with Cow Milk Allergy Expressed As Atopic Der- Children Prof. Man-Yong Han, MD, PhD , Department of Pedi- matitis and Gastrointestinal Disease atrics, CHA University School of Medicine, Seongnam, Dr. Juan Carlos Muino, MD, PhD, FAAAAI 1, Dr. Raul Boudet 1, South Korea, Prof. Heysung Baek, MD, PhD, Department of Pe- Dr. Maria Chaig 1, Dr. Roberto Chaig 1, Prof. Nelida Gerez 2 and diatrics, Hallym University College of Medicine, Seoul, South Prof. Juan Carlos Copioli1, 1FAC CS MED UNC, Cordoba, Argen- Korea and Prof. Ha-Baik Lee, MD, PhD, Department of tina, 2FAC CS MED UNC, C ordoba, Argentina Pediatrics, Hanyang University School of Medicine, Seoul, South 401 Detection Of Peanut Allergens In Breast Milk and Saliva Korea Dr. Kelli M. Rose, MD 1, Christian Plaisance 2, Casey C. Grimm, 393 Cross Reactivity Of Alpha Gal Allergy With An Extended Red PhD2, Hsiaopo Cheng, M.S. 2, Tysheena Charles, MS 2, Saeed A. Meat Panel Jortani3 and Soheila J. Maleki, PhD 2, 1Tulane University, New Or- Dr. Linda Flebbe-Rehwaldt, PhD , Viracor-IBT Laboratories, leans, LA, 2USDA-ARS-SRRC, New Orleans, LA, 3University of Lee’s Summit, MO and Dr. Michelle L. Altrich, PhD, Viracor- Louisville, Louisville, KY IBT Laboratories, Lee’s Summitt, MO 402 Importance Of High Molecular Weight Proteins In Walnut Al- 394 Prediction Of Tolerance To Food Allergens By The Allergen- lergy Specific IgE/Total IgE Ratio Melanie L. Downs, M.S. 1,2, Dr. Aida Semic-Jusufagic, MD 2, Dr. Ms. Claudia Lau1, Dr. Ruchi Gupta, MD, MPH 1,2, Dr. Aaron Don- Angela Simpson, MD 2, Prof. Adnan Custovic, MD, PhD, nell, MD 3, Prof. Robert G. Hamilton, PhD D.ABMLI FAAAAI 4 FAAAAI 2, Dr. Savas Savatianos, MD 3, Dr. Nikolaos G. Papadopou- and Dr. Kelly Newhall, MD 3, 1Ann and Robert H. Lurie Children’s los, MD, FAAAAI 3, Dr. Joan Bartra, MD, PhD 4, Dr. Montserrat Hospital of Chicago, Chicago, IL, 2Northwestern University Fein- Fernandez-Rivas 5, Joe L. Baumert 1, Steve L. Taylor, PhD 1 and berg School of Medicine, Chicago, IL, 3Chicago Family Asthma Prof. E.N. Clare Mills, BSc PhD2, 1Food Allergy Research and Re- & Allergy, Chicago, IL, 4Johns Hopkins University School of Med- source Program, University of Nebraska-Lincoln, Lincoln, NE, 2In- icine, Baltimore, MD stitute of Inflammation and Repair, University of Manchester, 395 T Regulatory Cells and Food Specific Responses In Peanut and Manchester, United Kingdom, 3Allergy Department, 2nd Pediatric Egg Allergic Children Clinic, University of Athens, Athens, Greece, 4Allergy Unit, Ser- Nashmia Qamar, DO , Anna B. Fishbein, Kristin A. Erickson, vice of Pneumology and Respiratory Allergy, Hospital Clinic Miao Cai, MS, Christine Szychlinski, MS, APN, CPNP, Ramsay (ICT), Barcelona, Spain, 5Allergy Department, Hospital Clinico L. Fuleihan, MD and Dr. Anne Marie Singh, MD, Division of Al- San Carlos, IdISSC, Madrid, Spain lergy & Immunology, Department of Pediatrics, Northwestern Uni- 403 Characterizing The Effect Of Sodium Sulfite On Cashew Aller- SUNDAY versity Feinberg School of Medicine, Ann & Robert H. Lurie gens Children’s Hospital of Chicago, Chicago, IL Christopher P. Mattison, PhD 1, Wendy A. Desormeaux 1, Dr. Ri- 396 Surveillance Of Persistent Nut Allergy Including The Use Of chard L. Wasserman, MD, PhD, FAAAAI 2 and Casey C. Grimm, Basophil Activation Test In Pediatric Patients PhD1, 1USDA-ARS-SRRC, New Orleans, LA, 2Allergy/Immunol- Dr. Ashleigh A. Olson, MD 1, Kristin A. Erickson 2, Miao Cai, MS 2, ogy Research Center of North Texas, Dallas, TX Ms. Christine Szychlinski, APN, CPNP3 and Dr. Anne Marie Singh, 404 Cross-Sensitization To Rosaceae and Their Molecular MD 2, 1Department of Pediatrics, Northwestern University Feinberg Components In Japanese School Children School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Dr. Junya Hirayama 1, Dr. Atsushi Yamashita 1, Dr. Mizuho Nagao, Chicago, Chicago, IL, 2Division of Allergy & Immunology, Depart- MD 1, Dr. Reiko Tokuda 1,2, Dr. Keigo Kainuma, MD 1 and Dr. Takao ment of Pediatrics, Northwestern University Feinberg School of Fujisawa, MD, FAAAAI 1, 1Institute for Clinical Research, Mie Na- Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, tional Hospital, 2Tokuda Family Clinic Chicago, IL, 3Northwestern University Feinberg School of Medi- 405 Food-Specific IgE Panel Testing Commonly Results In Misdiag- cine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chi- nosis and Inappropriate Dietary Exclusion cago, IL Dr. Maryam Saifi, MD , University of Texas Southwestern Medical 397 Assessment Of a Modified Basophil Activation Test In The Di- Center, Dallas, Mrs. Maria G. Crain, CPNPAE-C, Children’s Medical agnosis Of Peanut Allergy Center Dallas, Dallas, TX, Dr. Pooja Varshney, MD, Dell Children’s Dr. Monika Saeedian, MD , University of California, Los Angeles Medical Center,’Specially for Children, Austin, TX and Dr. J. Andrew and Dr. Maria Garcia-Lloret, MD, UCLA Bird, MD, FAAAAI, UT Southwestern Medical Center, Dallas, TX 398 Utility Of Probability Curves Using 3gAllergy For Diagnosis Of 406 Epitope Mapping The Peanut Panallergen Ara h 8 Wheat Allergy Barry K. Hurlburt, PhD 1, Hsiaopo Cheng, M.S. 1, Dr. Lesa Offer- Sakura Sato1, Kiyotake Ogura 1, Yasunori Sato 2 and Motohiro Ebi- mann2, Dr. Maksymilian Chruszcz, PhD 3, Dr. Alexandra F. Santos, sawa, MD, PhD, FAAAAI 1, 1Clinical Research Center for Allergy MD, MSc4, Prof. Gideon Lack, MD FRCPCH 5 and Soheila J. Mal- and Rheumatology, Sagamihara National Hospital, Kanagawa, Ja- eki, PhD1, 1USDA-ARS-SRRC, New Orleans, LA, 2university of pan, 2Department of Biostatistics, Clinical Research Center Chiba south carolina, columbia, SC, 3University of South Carolina, Co- University lumbia, SC, 4King’s College London, London, United Kingdom, 399 Skin Prick Test and Specific IgE To Purified Peanut Allergens 5St Thomas’ Hospital, St Thomas’ Hospital, London, United Are Related To The Age Of Onset Of Sympstons Kingdom Dr. Maria Salas, MD, PhD 1, Dr. Francisca Gomez, MD, PhD 2, Dr. 407 Simulated Roasting Affects Patient IgE Binding To Ara h 2 Ana Aranda, PhD3, Dr. Carmen Rondon, MD, PhD 1, Dr. Natalia Tysheena Charles, MS 1,2, Casey C. Grimm, PhD 2, Jane McBride 2, Blanca-Lopez, MD, PhD4, Dr. Gabriela Canto, MD, PhD 4, Dr. Ma- Samuel Landry, PhD 1 and Soheila J. Maleki, PhD 2, 1Tulane Univer- ria J Torres, MD, PhD 1, Dr. Cristobalina Mayorga, PhD 3, Dr. Mi- sity Health Sciences Center, New Orleans, LA, 2USDA-ARS- guel Blanca, MD, PhD1 and Maria Isabel Sanchez Rivas 5, SRRC, New Orleans, LA 1Allergy Service, Carlos Haya Hospital, M alaga, Spain, 2Allergy 408 Transfer Of Peanut IgE Sensitization Following Kidney and Service, Carlos Haya Hospital, Spain, 3Research Laboratory, Carlos Pancreas Transplant Haya Hospital-FIMABIS, Malaga, Spain, 4Allergy Service, Infanta Alalia , M.D. , University of Utah, Department of Medicine, Leonor Hospital, Madrid, Spain, 5Allergy Service Carlos Haya Salt Lake City, UT, Dr. Rafael Firszt, MD, MBA, Pediatrics, Uni- Hospital, Malaga, Spain versity of Utah, Salt Lake City, UT, Dr. Fuad Shihab, MD,

109 AB320 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

University of Utah,Division of Nephrology, Salt Lake City, UT, Dr. 2Neuropsychiatric Research Institute, Fargo, 3Genentech, Inc., Jeffrey Campsen, M.D. FACS, University of Utah, Division of South San Francisco, CA Transplant Surgery, Salt Lake City, UT and Craig Myrick, R.N., In- 415 Treatment With Off-Label Omalizumab In Chronic Idiopathic termountain Donor Services, Salt Lake City, UT Histaminergic Urticaria - Angioedema Resistant To Conven- tional Treatment Dr. Y. V. Rijo, MD 1, Dr. P. Palao, MD 1, Dr. N. Prior, MD 2, Dr. A. Fiandor, MD 1, Dr. M.C. Lopez-serrano, MD, PhD 1, Dr. S. Olalde, Urticaria MD 1, Mrs. M.C. Torres 1, Dr. S. Quirce, MD, PhD 1 and Dr. T. Ca- ballero, MD, PhD1, 1Hospital La Paz Institute for Health Research 3208 (IdiPaz), Allergy department., Madrid, Spain, 2Hospital Severo Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Ochoa, Madrid, Spain 409 Outcome Measures Of Challenge Testing In Patients With 416 Real-Life Experiences With Omalizumab For The Treatment Physically Induced-Urticaria Of Severe Refractory Chronic Urticaria (SRCIU) Dr. Dean D. Metcalfe, MD 1, Sarah Arceo, RN 1, Michael L. Young, Carly Barron1, Dr. Gordon L. Sussman, FAAAAI 1,2, Dr. Jacques RN MPH 2, Celeste Nelson, NP 1 and Dr. Hirsh D. Komarow, MD 3, Hebert, MD 3,4, Jiayi Bian 1, Rose-Marie Caron-Guay 4, Stephanie 1NIH/NIAID/Laboratory of Allergic Diseases, Bethesda, MD, Laflamme4 and Simon Stern1, 1Gordon Sussman Clinical Research 22Clinical Research Directorate/CMRP, SAIC-Frederick Inc, Fred- Inc., Toronto, ON, Canada, 2University of Toronto, Faculty of Med- SUNDAY erick National Laboratory for Clinic Research, Frederick, MD, icine, Toronto, ON, Canada, 3University Laval Center Hospital, 3Laboratory of Allergic Diseases, NIAID/NIH, Bethesda, MD Quebec City, QC, Canada, 4Centre de Recherche Appliqu ee en Al- 410 Whole Blood Histamine Concentration Response To Omalizu- lergie de Qu ebec, Qu ebec City, QC, Canada mab In Patients With Chronic Idiopathic/Spontaneous Urti- 417 Outcomes Of Chronic Urticaria Patients Treated With Hydrox- caria: Post Hoc Analysis Of Asteria I, Asteria II and Glacial ychloroquine Studies Dr. Jacqueline , Dr. Nicole Wilde and Dr. Maya R. Jerath, Dr. Sarbjit S. Saini, MD, FAAAAI 1, Dr. Karin Rosen, MD, PhD 2, MD, PhD, University of North Carolina, Chapel Hill, NC Dr. Hsin-Ju Hsieh, PhD 2, Ms. Patricia M. Sterba, MS 1, Mr. John- 418 Polymorphisms Of Genes Encoding Interleukin-4 and Its Re- Paul Courneya, MS 1, Dr. Henry Hulter 2 and Dr. Hubert Chen 2, ceptor Are Associated With Chronic Idiopathic Urticaria 1Johns Hopkins University, Baltimore, MD, 2Genentech, Inc., South Ms. Zahra Aryan1,2, Dr. Marzieh Tavakol 3,4, Prof. Ali Akbar San Francisco, CA Amirzargar, PhD 1, Prof. Masoud Movahedi 3, Dr. Alireza Zare bi- 411 Efficacy Of Omalizumab In Patients With Chronic Idiopathic/ doki3, Dr. Mohammad Gharagozlou, MD 3, Prof. Asghar Aghamo- Spontaneous Urticaria With Different Background Therapy: hammadi5, Dr. Mohammad Nabavi 6, Mr. Alireza Ahmadvand 3, Post Hoc Analysis Of Asteria I, Asteria II, and Glacial Studies Dr. Nasrin Behniafard, MD 3, Ms. Kimia Heidari 3, Ms. Samaneh Dr. Jonathan A. Bernstein, MD, FAAAAI 1, Dr. Sarbjit S. Saini, Soltani3 and Dr. Nima Rezaei, MD, PhD 1, 1Molecular Immunology MD, FAAAAI 2, Prof. Marcus Maurer, MD 3, Dr. Hsin-Ju Hsieh, Research Center; and Department of Immunology, School of Med- PhD4, Dr. Hubert Chen 4, Dr. Janice Canvin, MD, FRCPC 5, Dr. icine, Tehran University of Medical Sciences, Tehran, Iran, 2Na- Thomas B. Casale, MD, FAAAAI 6, Dr. Allen P. Kaplan, MD, tional elites foundation, Iran., 3Molecular Immunology Research FAAAAI 7 and Dr. Karin Rosen, MD, PhD 4, 1Division of Immunol- Center; and Department of Immunology, School of Medicine, Teh- ogy Allergy & Rheumatology, University of Cincinnati Medical ran University of Medical Sciences, Tehran, Iran, Iran, 4Student Center, Cincinnati, OH, 2Johns Hopkins University, Baltimore, Scientific Research Center (SSRC), School of Medicine, Tehran MD, 3Department of Dermatology and Allergy, Charit e – Univer- University of Medical Sciences, Tehran, Iran, 5Research Center sit€atsmedizin, Berlin, Germany, 4Genentech, Inc., South San Fran- for Immunodeficiencies, Children’s Medical Center, Tehran Univer- cisco, CA, 5Novartis Pharmaceuticals UK Limited, Horsham, West sity of Medical Sciences, Tehran, Iran, 6Department of Allergy and Sussex, United Kingdom, 6Univeristy Of South Florida Morsani Immunology, Rasool-e-Akram Hospital, Tehran University of Med- College Of Medicine, Tampa, FL, 7Medical University of South ical Sciences, Tehran, Iran, Iran Carolina, Charleston, SC 419 Chronic Idiopathic Urticaria Index (CIUI) As a Tool For Pre- 412 Angioedema and Angioedema Management From Asteria I and dicting Response To Cyclosporine In Pediatric Patients With Asteria II: Phase III Studies To Evaluate The Efficacy and Refractory Autoimmune Urticaria Safety Of Omalizumab In Patients With Chronic Idiopathic/ Dr. Moira E. Breslin, MD, MSc , Pediatrics, UCLA Medical Cen- Spontaneous Urticaria Who Remain Symptomatic Despite H1 ter, Los Angeles, CA, Dr. Bob Geng, MD, UCLA, Los Angeles, CA Antihistamine Treatment and Dr. Robert Roberts, MD, PhD, UCLA Dr. James Zazzali, PhD , Dr. Karin Rosen, MD, PhD, Mary S. 420 Cholinergic Urticaria: Case Report Of Urticaria Induced By Bradley, MS and Karina Raimundo, BPharm, MS, Genentech, Acquired Seasonal Hypohidrosis Inc., South San Francisco, CA Dr. Yuriy Zgherea, MD , Dr. Muhammad Imran, MD, Dr. Jaron T. 413 Improvements In Health-Related Quality Of Life From Asteria Abbott, MD, Dr. Aaron K. Pinion, DO, Dr. Selina Gierer, DO and I & II: Phase III Studies To Evaluate The Efficacy and Safety Dr. John D. Martinez, MD, University of Kansas Medical Center Of Omalizumab In Patients With Chronic Idiopathic/Spontane- 421 Relation Between Environmental Allergen Exposure and ous Urticaria Who Remain Symptomatic Despite H1 Antihista- Chronic Urticaria mine Treatment Dr. Denisa Ferastraoaru, MD, MSc , Allergy - Immunology, Al- Karina Raimundo, BPharm, MS , Dr. James Zazzali, PhD, Benja- bert Einstein College of Medicine / Montefiore Medical Center, min Trzaskoma and Dr. Karin Rosen, MD, PhD, Genentech, Inc., Bronx, NY, Dr. Sunit Jariwala, MD, Albert Einstein/Montefiore South San Francisco, CA Medical Center, New York, NY, Dr. Golda Hudes, MD, PhD, Albert 414 Estimating The Minimal Important Difference (MID) Of The Einstein/ Montefiore Medical Center, New York, NY and Dr. David Measures In The Urticaria Patient Daily Diary (UPDD): Up- L. Rosenstreich, MD, FAAAAI, Albert Einstein/Montefiore Medi- dated Findings Using Data From The Asteria I, Asteria II, cal Center, Bronx, NY and Glacial Studies Of Omalizumab In Chronic Idiopathic/ 422 Relationship Of Clinical Characteristics Of Chronic Urticaria Spontaneous Urticaria In Children To Treatment Outcome Susan Mathias1, Dr. Ross D. Crosby 2, Dr. Karin Rosen, MD, PhD 3 Lisa Neverman, B.S. and Prof. Miles M. Weinberger, MD, and Dr. James Zazzali, PhD 3, 1Health Outcomes Solutions, FAAAAI, University of Iowa, Iowa City, IA

110 J ALLERGY CLIN IMMUNOL Abstracts AB321 VOLUME 133, NUMBER 2

423 Clinical Characteristics Of Elderly Chronic Urticaria 434 Acute Urticaria Caused By Infection In 72 Chinese Patients Dr. Ga Young Ban, MD 1, Ji Hye Kim, MD 2, Mi-Yea Kim, MD 1, Prof. Ting Xiao , The First Affiliated Hospital, China Medical Uni- Dr. Hye-Soo Yoo, MD 1, Dong-Ho Nahm, MD, PhD 1, Dr. Young versity, Shenyang, China and Dr. Lin Zhu, The First Affiliated Hos- Min Min Ye, MD 1, Yoo Seob Shin, MD, PhD 1 and Prof. Hae- pital, China Medical University Sim Park, MD, PhD 1, 1Department of Allergy & Clinical Immunol- 435 Assessment Of Acute Urticaria In Pediatric Emergency Depart- ogy, Ajou University School of Medicine, Suwon, South Korea, ment 2Department of Internal medicine, Konyang University College of Dr. Raquel Reis Pitchon, Clinical Research 1, Mr. Daniel Reis, Medicine, Daejeon, South Korea Medical Student2, Ms. Adriana Reis, Medical Student 3, Mr. Andr e 424 Decreased Serum Vitamin D Level In Patients With Chronic Chuster, Medical Student 3, Prof. Teresa Mohallen, Professor 2, Dr. Spontaneous Urticaria Jose Ribeiro, Pediatrician 4, Dr. N ıvea Claret, Pediatrician4, Dr. Dr. Tadech Boonpiyathad, MD , Dr. Panitan Pradappongsa and Dr. Giane Chaves, Pediatrician4, Dr. Virgilio Aleixo, Pediatrician 4, Atik Sangasapaviriya, Phramonkutklao Hospital, Bangkok, Thailand Dr. Maria do Socorro Fernandes, Pediatrician 4 and Dr. Fausto Pa- 425 Supplementation With Vitamin D In a Cohort Of Patients With checo, Pediatrician4, 1Mater Dei Hospital, BELO HORIZONTE, Chronic Urticaria Results In Clinical Improvement Brazil, 2Universidade Federal de Minas Gerais, BELO HORI- Dr. Anastasiya Kleva, MD , Dr. Sherry Farzan, MD and Dr. Blanka ZONTE, Brazil, 3Faculdade de Ciencias M edicas, BELO HORI- M. Kaplan, MD, FAAAAI, Department of Pediatrics, Division of ZONTE, Brazil, 4Hospital Mater Dei, BELO HORIZONTE, Brazil Allergy & Immunology, Hofstra-North Shore-LIJ School of Medi- 436 OTC Pills and Severe Urticaria cine, Great Neck, NY Ivan Cherrez 1, Enrique Loayza 2, Leonardo Greiding 3, Jose M. Vi- 426 Clinical and Laboratory Features Of Chronic Urticaria lema4, Juan Calderon 4, Erick Calero 4 and Gabriela Martinetti4, Dr. Koji Masuda , Kyoto Prefectural University of Medicine, 1Respiralab - Hospital Kennedy, Guayaquil, Ecuador, 2Respiralab Kyoto, Japan - Hospital Luis Vernaza, Guayaquil, Ecuador, 3Instituto Argentino 427 Serum Specific IgE Response To Thyroid Autoantigens In Aspi- de Alergia e Inmunologia, Buenos Aires, Argentina, 4Respiralab, rin Intolerant Urticaria Patients Guayaquil, Ecuador Dr. Yoo Seob Seob Shin, MD, PhD , Dr. Hye-Soo Yoo, MD, Dr. 437 Hypocomplementemic Urticarial Vasculitis With Elevated Im- Ga Young Ban, MD, Dr. Young Min Min Ye, MD and Prof. Hae- mune Complexes and Nasal Polyposis Sim Park, MD, PhD, Department of Allergy & Clinical Immu- Dr. Khrystyna Lishchuk-Yakymovych, MD , Medical University, nology, Ajou University School of Medicine, Suwon, South , Ukraine, Dr. Roman Pukalyak, Danylo Halytskyy Lviv Na- Korea tional Medical University, Ukraine and Prof. Lawrence M. Du- 428 Basophil Receptor Profiles In Chronic Idiopathic Urticaria Buske, MD, FAAAAI, George Washington University School of SUNDAY Dr. Eric Oliver, MD , Ms. Patricia M. Sterba, MS and Dr. Sarbjit S. Medicine, DC Saini, MD, FAAAAI, Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 429 Altered Systemic Adipokine Levels In Patients With Chronic Pediatric Population Health Idiopathic Urticaria Dr. Young Min Ye, MD , Dr. Ga Young Ban, MD, Eun-Mi Yang, 3209 Dr. Hye-Soo Yoo, MD, Yoo Seob Shin, MD, PhD and Prof. Hae- Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Sim Park, MD, PhD, Department of Allergy & Clinical Immu- 438 Nannies Knowledge, Attitude and Management Of Food Aller- nology, Ajou University School of Medicine, Suwon, South gies In Children; An Online Survey Korea Dr. Justin C. Greiwe, MD 1, Dr. Lisanne P. Newton, MD 2, Dr. Fou- 430 Predicting Clinical Responsiveness To Dapsone In The Treat- seena Pazheri, MD 3 and Dr. Brian C. Schroer, MD 2, 1Cleveland ment Of Chronic Idiopathic Urticaria (CIU) Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, Dr. Ryan A. Steele, DO, MS 1, Dr. Janelle Sher, MD 2, Dr. Mark OH, 3Cleveland Clinic Davis-Lorton, MD, FAAAAI 2, Dr. Marcella R. Aquino, MD, 439 Does Omega-3 Fatty Acid Supplementation During Pregnancy FAAAAI 2 and Dr. Luz S. Fonacier, MD, FAAAAI 3, 1Allergy & Im- Prevent Childhood Atopic Disease? munology, Winthrop University Hospital, Mineola, NY, 2Winthrop Dr. Manika Girdhar, DO , Children’s Mercy Hospital & Clinics, University Hospital, Allergy & Immunology, Mineola, NY, 3Section Kansas City, MO and Dr. Christina E. Ciaccio, MD, FAAAAI, Chil- of Allergy and Clinical Immunology, Department of Medicine, dren’s Mercy Hospital, Kansas City, MO Winthrop University Hospital, Mineola, NY 440 Helping Children Cope With Discomfort Associated With Skin 431 Chronic Urticaria/Angioedema and Auto-Immunity: Diagnostic Prick Testing In a Pediatric Setting: A Quality Improvement Profile Among Patients Attending a Reference Clinic In Brazil Report Dr. Daniel L. Cordeiro, MD 1, Dr. Janaina Fernandes de Melo Ms. Amanda Troger, BSN, RN 1, Ms. Humaira Robinson, BSN Sousa, MD 1, Dr. Karine Boufleur, MD 1, Dr. Priscila Botelho Palhas, RN 1, Ms. Sonia C. Mancia, RN 2, Dr. Hemant P. Sharma, MD MD 1, Dr. Tha ıs Mendonc¸a, MD 1, Dr. Janaina Michele de Lima MHS FAAAAI 3 and Dr. Katherine Kelly, PhD, RN 1, 1Children’s Melo, MD 1 and Dr. Luisa Karla P. Arruda, MD, PhD, FAAAAI 2, National Medical Center, Washington, DC, 2Children’s National 1Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Medical Center, Fairfax, VA, 3Children’s National Medical Center Preto, Brazil, 2School of Medicine of Ribeirao Preto, Ribeirao 441 Are Total Serum IgE Levels Good Predictors Of Allergies In Preto, Brazil Children? 432 Chronic Spontaneous Urticaria-The Saskatchewan Experience Dr. Stephanie Barnes-Mercado 1, Dr. Vylma Velazquez, MD 2 and and Questionnaire Survey Dr. Annette Pietri-Ramirez 1, 1Hospital Episcopal San Lucas-Ponce, Ms. Natasha Gattey, University of Saskatchewan, Saskatoon, SK, 2Hospital Episcopal San Lucas, Ponce, PR Canada 442 Relationship Between Maternal Fat During Pregnancy and 433 A Case Of Incontinentia Pigmenti Masquerading As Urticaria Risks Of Allergic and Respiratory Diseases In Early Childhood: Pigmentosa The Mothers and Children’s Environmental Health Study Dr. Erin C. Donahue, MD and Dr. Sonal R. Patel, MD, White Me- Prof. Ja Hyeong Kim, MD 1, Prof. Eun-Hee Ha, MD 2, Prof. Hye morial Medical Center, Los Angeles, CA sook Park, MD 2, Prof. Mina Ha, MD 3, Prof. Yun-Chul Hong,

111 AB322 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

MD 4, Prof. Yangho Kim, MD 5, Mr. Min-ho Kim, PhD 6, Prof. Jin-A 450 Experience In The Development Of a Mobile Diagnosis Support Jung, MD 7 and Prof. NamSoo Chang, PhD8, 1Ulsan University System For Asthma: Intelimed Hospital, Ulsan, South Korea, 2Department of Preventive Medicine, Prof. Silvia Wanick Sarinho Sr., Prof.Dr. 1, Prof. J ulio Ven ^ancio School of Medicine, Ewha Womans University, South Korea, 3De- Menezes Junior 1, Prof. Cristine Gusm ~ao 1 and Nilza R S Lyra, partment of Preventive Medicine, Dankook University College of MD 2, 1Universidade Federal de Pernambuco, 2Universidade Federal Medicine, 4Department of Preventive Medicine, Seoul National de Pernambuco, Recife PE, Brazil University College of Medicine, South Korea, 5Department of Oc- 451 An Assessment Of Food Allergy Knowledge Among Parents Of cupational and Environmental Medicine, University of Ulsan, Col- Children With Food Allergy and The Role Of An Educational lage of Medicine, Ulsan University Hospital, South Korea, 6Ulsan Website University Hospital, South Korea, 7Dong-A University College of Jamee Castillo, MD 1, Neha Mehrotra, MD 1, Raoul L. Wolf, MD, Medicine, Busan, 8Department of Nutritional Science and Food FAAAAI 2 and Ves Dimov, MD 3, 1Internal Medicine Residency Pro- Management, Ewha Womans University, Seoul, Korea, South gram, Department of Medicine, University of Chicago, Chicago, IL, Korea 2Section of Allergy, Asthma and Immunology, Department of Pedi- 443 The Efficacy Of Training School and Nursery Personnel On Ep- atrics, Department of Medicine, University of Chicago, Chicago, inephrine Autoinjector Use IL, 3University of Chicago Medicine, Chicago, IL Dr. Mari Sasaki, MD , Dr. Mayumi Furukawa, MD, Dr. Koichi Yoshida, MD and Dr. Akira Akasawa, MD, PhD, Division of Al- SUNDAY lergy, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 444 Referral Patterns To An Outpatient Allergy/Immunology Clinic At a Tertiary Care Pediatric Academic Center Chronic Rhinosinusitis and Polyps Kasey Strothman, MD 1,2, David R. Stukus, MD, FAAAAI 1 and Rebecca Scherzer, MD, FAAAAI 1, 1Nationwide Children’s Hospi- 3211 tal, Columbus, OH, 2Wexner Medical Center at The Ohio State Uni- Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM versity, Columbus, OH 452 The Differences Of TNF- a, Rantes, Interleukin-5 Levels In Na- 445 Food Allergy Education Significantly Improves School Person- sal Polyps With Allergic, Local Allergic, and Non-Allergic Rhi- nel Food Allergy Knowledge and Bullying Attitudes nitis Niti Y. Chokshi, MD 1, Kristin H. Dillard, MD 1, Danielle Guffey, Prof. Jae-Won Oh, MD, PhD, FAAAAI , Hanyang University Guri MS 2, Charles Minard, PhD 2 and Carla M. Davis, MD 1, 1Baylor Hospital, Seoul, Dr. Joo-Hwa Kim, MD, Hanyang University Guri College of Medicine and Texas Children’s Hospital, Section of Im- Hospital, Seoul, South Korea and Dr. JIn-Hyuk Cheong, Hanygang munology, Allergy and Rheumatology, Houston, TX, 2Baylor Col- University Guri Hospital, Guri, South Korea lege of Medicine, Houston, TX 453 Cigarette Smoke Promotes Eosinophilic Inflammation, Airway Remodeling and Nasal Polyps In a Murine Polyp Model Dr. Ji-Hun Mo , Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, South Korea and Ki-Il Lee, Dankook university, South Korea Health Information Technology 454 Evaluation Of Oral Antibiotics Versus Placebo For The Treat- ment Of Rhinosinusitits With Neutrophilia On Nasal Cytology 3210 Manar Abdalgani, MD 1, Dr. Joud Hajjar, MD 2, Krista Edelman, Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM MD 1 and Dr. Lawrence B. Schwartz, MD, PhD, FAAAAI 1, 1Vir- 446 How Patients Rate Their Allergists Online: Analysis Of Physi- ginia Commonwealth University, Richmond, VA, 2Baylor Colleage cian-Review Websites of Medicine, Houston, TX Xiao C. Wan, M.D. , University of Chicago, Department of Internal 455 Pediatric Allergic Fungal Otomastoiditis Improved With Anti- Medicine, Chicago, IL and Ves Dimov, MD, Section of Allergy, IgE Therapy Asthma and Immunology, Department of Pediatrics, Department Dr. Diana K. Bayer, DO 1, Dr. Ankhi Dutta, MD, MPH 2,3, Dr. Rob- of Medicine, University of Chicago, Chicago, IL ert Williamson, MD 4, Dr. Andrew deJong, MD 3,5, Dr. Keith Paull, 447 Improving Allergy and Immunology Education For The Internal MD 3,6, Dr. I. Celine Hanson, MD, FAAAAI 1 and Dr. Lisa R. For- Medicine Resident Through Internet-Based Learning Modules bes, MD 1, 1Baylor College of Medicine-Texas Children’s Hospital, Dr. Michelle C. Fox, MD 1,2, Dr. Paige G. Wickner, MD 3 and Dr. Ma- Section of Immunology, Allergy, and Rheumatology, Houston, TX, riana C. Castells, MD, PhD, FAAAAI 4, 1Brigham and Women’s Hos- 2Health Point ABC Clinic, College Station, TX, 3Texas A&M pital, 2Harvard Medical School, 3Brigham & Women’s Hospital, Health Science Center, Bryan, TX, 4Texas Children’s Hospital-Bay- Chestnut Hill, MA, 4Division of Rheumatology, Allergy and Immu- lor College of Medicine, Department of Surgery, Otolaryngology, nology, Department of Medicine, Brigham and Women’s Hospital, Houston, TX, 5Texas ENT and Allergy, Bryan, TX, 6The Paull Al- Harvard Medical School, Boston, MA lergy and Asthma Clinic, Bryan, TX 448 Electronic Patient Data Acquisition Tablet (ePDAT) Provides 456 Measurement Of Nasal and Exhaled Nitric Oxide In Chronic Customized, Flexible Scheduling For Collecting Patient Re- Rhinosinusitis and Its Comparison According To The Presence ported Outcomes (ePRO) With High Usability and Compliance Of Nasal Polyps Ideal For Use In Single and Multicenter Environmental Expo- Dr. Woo Yong Bae, MD , Department of Otorhinolaryngology, Col- sure Chamber Studies lege of Medicine, Dong-A University, Busan, South Korea, Prof. Mr. Dan Wilson , Dr. Piyush Patel, MD, FRCP, Konrad Boczula Jin-A Jung, MD, Dong-A University College of Medicine, Busan and Dr. AnneMarie Salapatek, PhD, Inflamax Research, Missis- and Dr. Young-Hee Nam, MD, Department of Internal Medicine, sauga, ON, Canada College of Medicine, Dong-A University, Busan, South Korea 449 Feasibility and Acceptability Of a Novel Asthma Self-Manage- 457 Post-Translational Modification By Serine Proteases Controls ment Smartphone Application For Children and Adolescents The CCL23 Activity In Nasal Polyps Of Chronic Rhinosinusitis Nabeel Farooqui, MD 1,2, Gary Phillips, M.A.S. 2 and David R. Stu- Dr. Atsushi Kato, PhD 1, Dr. Anjeni Keswani, MD 1, Dr. Julie Kim, kus, MD, FAAAAI 1,2, 1Nationwide Children’s Hospital, Columbus, M.D.1, Ms. Julie Poposki, MS 1, Dr. Sarah Peterson, MD 1, Ms. Ly- OH, 2Wexner Medical Center at The Ohio State University, Colum- dia Suh, BSc1, Mr. James Norton, MS 1, Dr. Anju T. Peters, MD, bus, OH FAAAAI 1, Dr. Kathryn E. Hulse, PhD 2, Dr. Leslie C. Grammer,

112 J ALLERGY CLIN IMMUNOL Abstracts AB323 VOLUME 133, NUMBER 2

MD, FAAAAI 1, Dr. Bruce K. Tan, MD 3, Dr. Rakesh Chandra, MD, FAAAAI 1, Dr. Joy Hsu, MD, MSCI 1, Prof. Pedro C. Avila, MD 2, Dr. David Conley, MD 3, Dr. Juan Jaen, PhD 4, Dr. Thomas MD, FAAAAI 1, Mr. James Norton, MS 1, Ms. Lydia Suh, BSc 1, Schall, PhD4, Dr. Robert C. Kern, MD 1,3 and Dr. Robert P. Dr. Rakesh Chandra, MD 2, Dr. David Conley, MD 3, Dr. Robert Schleimer, PhD FAAAAI 5, 1Department of Medicine, Division of C. Kern, MD 3, Dr. Bruce K. Tan, MD 3 and Dr. Robert P. Schleimer, Allergy-Immunology, Northwestern University Feinberg School PhD FAAAAI 4, 1Department of Medicine, Division of Allergy-Im- of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, munology, Northwestern University Feinberg School of Medicine, 3Department of Otolaryngology, Northwestern University Feinberg Chicago, IL, 2Northwestern University, Chicago, IL, 3Department School of Medicine, Chicago, IL, 4Chemocentryx Inc, Mountain of Otolaryngology, Northwestern University Feinberg School of View, CA, 5Division of Allergy-Immunology, Department of Med- Medicine, Chicago, IL, 4Division of Allergy-Immunology, Depart- icine, Northwestern University Feinberg School of Medicine, Chi- ment of Medicine, Northwestern University Feinberg School of cago, IL Medicine, Chicago, IL 458 Sinusitis In Latino Children Is Associated With Allergic Respi- 462 Expression Of Hypoxia-Inducible Factor 1alpha In Regulatory ratory Diseases and Inversely Related To Native American An- T Cells Is Associated With Nasal Polypogenesis cestry (GALA II Study) Prof. Yong Min Kim 1, Dr. Jun Jin 2, Dr. Dong-Yeop Chang 3, Sung Dr. Jennifer A. Regan, MD, PhD 1, Dr. Joy Hsu, MD, MSCI 2, Ms. Ha Kim 4 and Ki-Sang Rha4, 1Chungnam National University Elizabeth Nguyen, BS 3, Ms. Lindsey Roth, MA 4, Dr. Joshua Gal- School of Medicine, Daejeon, South Korea, 2Chungnam National anter, MD 4, Dr. Sam Oh, PhD, MPH 4, Ms. Celeste Eng, BS 4, Mr. University School of Medicine, 3Laboratory of Immunology and In- Fred Lurmann, MS 5, Dr. Rajesh Kumar, MD, MS, FAAAAI 6, Dr. fectious Diseases, Graduate School of Medical Science and Engi- Harold J. Farber, MD, MSPH 7, Dr. Denise Serebrisky, MD 8, Dr. neering, KAIST, Daejeon, South Korea, 4Chungnam National Luisa Borrell, DDS, PhD9, Dr. Saunak Sen, PhD 10 , Dr. William Ro- University School of Medicine, South Korea driguez-Cintron, MD 11 , Dr. Jose Rodriguez-Santana, MD 12 , Dr. Es- 463 Prognoistic Factors For Olfaction After Endoscopic Sinus Sur- teban Gonza Burchard, MD, MPH4 and Prof. Pedro C. Avila, MD, gery In Chronic Sinusitis With Or Without Allergy FAAAAI 1, 1Feinberg School of Medicine, Northwestern University, Dr. Byung Guk KIM 1, Jihyun SHIN 2, Chan Soon PARK 2, Dr. Soo Chicago, IL, 2Department of Medicine, Division of Allergy-Immu- Whan Kim 3, JUN Myung Kang 2 and So Young PARK 2, 1The Catholic nology, Northwestern University Feinberg School of Medicine, University Of Korea, Seoul, Korea, South Korea, 2The Catholic Univer- Chicago, IL, 3Department of Medicine, University of California, sity Of Korea, Seoul, Korea, 3The Catholic University of Korea San Francisco, California, San Francisco, CA, 4Department of Medicine, University of California, San Francisco, San Francisco, CA, 5Sonoma Technology, Inc., Petaluma, CA, 6Pediatric allergy, SUNDAY Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 7Baylor College of Medicine and Texas Children’s Hospital, Rhinitis Houston, TX, 8Pediatric Pulmonary Division, Jacobi Medical Cen- ter, Bronx, NY, 9Department of Health Sciences, Graduate Program 3212 in Public Health, Lehman College, City University of New York, Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM Bronx, NY, 10 Department of Epidemiology and Biostatistics, Uni- 464 The Association Between Two SNPs GATA3 (rs1269486, versity of California, San Francisco, San Francisco, CA, 11 Veterans rs2229360) Gene and Allergic Rhinitis Caribbean Health Care System, San Juan, PR, 12 Centro de Neumo- Prof. Reza Farid, MD, FAAAAI , Allergy Research Center, Mash- logia Pediatrica, San Juan, PR had University of Medical Sciences, Iran, Prof. mohammad Raza 459 Evaluation Of Olfactory Function In Patients With Chronic Abbaszadegan, 1. Genetic Research Center,Mashhsd University of Rhinitis Medical Science, mashhad, Iran, Prof. Farahzad Jabbari, Allergy re- Dr. Idalia V. Yanez-Perez, MD , Dr. Sandra N. Gonzalez-Diaz, search center, Mashhsd University of Medical Science, Mashhad, MD, PhD, FAAAAI, Dr. Alejandra Macias-Weinmann, Dr. Alfredo Iran, Prof. Mehran Gholamin, Immunology Research Center,1. Arias-Cruz, Dr. Lorena Rangel-Garza, Dr. Hilda Hernandez-San- Mashhsd University of Medical Science, mashhad, Iran, Dr. Afshin chez, MD, Dr. Rafael Perez-Vanzzini and Dr. Karla Mejia-Salas, Shirkani, MD, Bushehr University of Medical Science, Mashhad, Regional Center of Allergy and Clinical Immunology. University Iran, Mrs. Hadis Yousefzadeh, allergy Research Center. Mashhsd Hospital ‘‘Dr. Jose Eleuterio Gonzalez’’., Monterrey, Mexico University of Medical Science, mashhad, Iran and Ms. Atena Man- 460 A Method For Assessing Regional Determinants Of Eosino- souri, buoshar university, Iran philia In Chronic Rhinosinusitis 465 Impacts Of Adolescents’ Allergic Rhinitis On School Achieve- Dr. Bruce K. Tan, MD 1, Ms. Erin Rocci, BS 2, Dr. Kent Lam, MD 1, ment and Quality Of Life Ms. He Huang, MS 1, Ms. Lydia Suh, BSc 3, Mr. Avesh Thuluvath, Prof. Sun-Hee Choi, MD, PhD 1, Dr. Kyung Suk Lee, MD, PhD 2 BA 4, Ms. Alcina K. Lidder, BA 1, Dr. Rakesh Chandra, MD 5, Dr. and Prof. Yeong-Ho Rha, MD, PhD 2, 1Gangdong Kyung Hee Uni- David Conley, MD 1, Dr. Stephanie Shintani-Smith, MD 1, Dr. Ka- versity Hospital, Seoul, South Korea, 2Kyung Hee University thryn E. Hulse, PhD 5, Dr. Atsushi Kato, PhD 3, Dr. Anju T. Peters, Hospital MD, FAAAAI 3, Dr. Leslie C. Grammer, MD, FAAAAI 3, Dr. Robert 466 Allergic Rhinitis (AR) Is Sub-Optimally Controlled: The Need C. Kern, MD 1 and Dr. Robert P. Schleimer, PhD FAAAAI 6, 1De- For a More Effective Treatment Option partment of Otolaryngology, Northwestern University Feinberg Dr. Phillip L. Lieberman, MD, FAAAAI , Allergy and Asthma As- School of Medicine, Chicago, IL, 2Loyola University Stritch School sociates, Germantown, TN and Prof. David Price, FRCGP, MRCGP, of Medicine, Chicago, IL, 3Department of Medicine, Division of DRCOG, Research In Real Life, Cambridge, United Kingdom Allergy-Immunology, Northwestern University Feinberg School 467 Short and Long-Term Safety Of MP29-02 In The Treatment Of of Medicine, Chicago, IL, 4Northwestern University- Feinberg Allergic Rhinitis School of Medicine, Chicago, IL, 5Northwestern University, Chi- Dr. William Berger, MD , Allergy & Asthma Associates of South- cago, IL, 6Division of Allergy-Immunology, Department of Medi- ern California, Mission Viejo, CA, Dr. Jonathan A. Bernstein, MD, cine, Northwestern University Feinberg School of Medicine, FAAAAI, Division of Immunology Allergy & Rheumatology, Uni- Chicago, IL versity of Cincinnati Medical Center, Cincinnati, OH, Dr. Nancy 461 The Prevalence Of AERD In a Tertiary Care Center Ruiz, MD, MEDA Pharmaceuticals, Somerset, NJ and Dr. Warner Dr. Whitney Wyatt Stevens, MD, PhD 1, Dr. Anju T. Peters, MD, W. Carr, MD, FAAAAI, Allergy and Asthma Associates of SCs, FAAAAI 1, Dr. Kathryn E. Hulse, PhD 2, Dr. Leslie C. Grammer, Mission Viejo, CA

113 AB324 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

468 Anti-Allergic Effect Of Intranasal 1,25-Dihydroxyvitamin D3 MD 4, Dr. Kelly Bethel 5, Ms. Rachel Baum, B.S. 4, Mr. Sean Treatment In Allergic Rhinitis Mouse Model Lund, B.S.6, Naseem Khorram, M.S. 6, Dr. David R. Scott, M.D. 7, Dr. Dong-Young Kim , Division of Allergy-Immunology, Depart- Dr. David H. Broide, MB ChB FAAAAI 8 and Dr. Taylor A. Doh- ment of Medicine, Northwestern University Feinberg School of erty, MD, FAAAAI 9, 1University of California, San Diego, San Medicine, Chicago, IL; Department of otorhinolaryngology, Seoul Diego, CA, 2Scripps Clinic Medical Group, San Diego, CA, national university college of medicine, Seoul, Korea and Dr. Jae- 3Scripps Clinic, San Diego, CA, 4University of California, San Min Shin, Department of Otorhinolaryngology-Head and Neck Sur- Diego, 5Scripps Green Hospital, 6University of California, San gery, Soon Chun Hyang University Hospital, Seoul, South Korea Diego, La Jolla, CA, 7Allergy and Asthma Center of Western Col- 469 B-Cells In Allergic Airways Disease: Inhibition Of Epsilon orado, 8Department of Medicine, San Diego, CA, 9Medicine, Uni- Transcription By Omalizumab versity of California, San Diego, San Diego, CA Dr. Marylin Desjardins, MD 1,2, Dr. Jean-Philippe Drolet, MD 3, 477 Innate and Adaptive Lymphocyte Responses In a Mouse Model Ms. Marianne Beland2, Dr. Sam Daniel, MD 1 and Dr. Bruce D. Ma- Of Rhinovirus-Induced Asthma Exacerbation zer, MD, FAAAAI 1,4, 1Montreal Children’s Hospital, Montreal, Dr. Annabelle Jayaraman, PhD , Dr. Nathan Bartlett, PhD and QC, Canada, 2Meakins-Christie Laboratories, Montreal, QC, Can- Prof. Sebastian L. Johnston, MD, PhD, Imperial College London, ada, 3Centre Hospitalier Universitaire de Quebec, Quebec, QC, London, United Kingdom Canada, 4Meakins-Christie Laboratories, Research Institute - 478 Aspergillus Fumigatus May Promote Th2 Activation By Sup- McGill University Health Centre, Montreal, QC, Canada pression Of Interferon Signaling SUNDAY 470 Early Childhood Allergic Phenotypes Are Associated With In- Dr. Tetsuya Homma, MD 1,2, Mr. Bharat Bhushan 1,3, Dr. Atsushi ternalizing Disorders Kato, PhD1, Mr. James Norton, MS 1, Ms. Lydia Suh, BSc 1, Dr. Maya Nanda, MD 1, Linda Levin, PhD 2, Grace K. LeMasters, PhD 2, Quan Sha, MD, PhD4, Dr. Dave S. Gupta, MD 5 and Dr. Robert P. Amal H. Assa’ad, MD, FAAAAI 1, Nicholas Newman, DO, MS 1 and Schleimer, PhD FAAAAI 6, 1Department of Medicine, Division of Patrick Ryan, PhD1, 1Cincinnati Children’s Hospital Medical Center, Allergy-Immunology, Northwestern University Feinberg School Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH of Medicine, Chicago, IL, 2Department of Internal Medicine, Divi- 471 Allergic Rhinitis In Puerto Rican Children: Under-Diagnosis sion of Respiratory Medicine and Allergology, Showa University and Risk Factors School of Medicine, Tokyo, Japan, 3Division of Otolaryngology- Dr. Tammy S. Jacobs, MD, MA , Dr. Erick Forno, MD, MPH, Dr. Head and Neck Surgery, Ann & Robert H. Lurie Children’s Hospi- John M. Brehm, MD, MPH, Dr. Yueh-Ying Han, PhD, MS and Dr. tal of Chicago, 4Allergy and Immunology research center, Anhui Juan C. Celedon, MD, DrPH, FAAAAI, Children’s Hospital of Medical University, China, 5Department of Allergy Immunology, Pittsburgh of UPMC, Pittsburgh, PA National Jewish Health, Denver, CO, 6Division of Allergy-Immu- 472 Hematopoietic Prostaglandin D Synthase Is a Useful Target For nology, Department of Medicine, Northwestern University Feinberg Treating Nasal Obstruction In Guinea Pigs With Allergic Rhi- School of Medicine, Chicago, IL nitis 479 Heterogeneity Of Specific CD4+ T Cell Responses To Peanut Al- Daisuke Kajiwara, Hiroki Aoyagi, Kazuhiko Shigeno, Katsunao lergic Components: Prospects For Specific Immunotherapy Tanaka, Eiji Sasaki and Teruhiro Utsugi, Tsukuba Research Center, Dr. Erik R. Wambre, PhD , Benaroya Research Institute, Seattle, TAIHO PHARMACEUTICAL CO.,LTD. WA, William W. Kwok, PhD, Benaroya Research Institute at Vir- 473 Efficacy Of MP29-02 In The Treatment Of Nasal and Ocular ginia Mason, Seattle, WA and Dr. David Robinson, Virginia Mason Symptoms Of Seasonal Allergic Rhinitis (SAR) Medical Center Dr. Paul H. Ratner, MD, FAAAAI , Sylvana Research, San Antonio, 480 Vitamin D Supplementation Reduces Th17 Cells In The Lung TX, Dr. Frank Hampel, MD, Central Texas Health Research, Dr. Julius and Spleen Of CRA-Sensitized and Challenged Mice VanBavel, MD, Allergy and Asthma Research Associates, Austin, TX Ankita Aggarwal1, Greg Perry 1, Vikash Kansal 2, Min-Jung Kim 1 and Dr. Nancy Ruiz, MD, MEDA Pharmaceuticals, Somerset, NJ and Devendra K. Agrawal 1, 1Department of Medical Microbiology 474 Atypical Symptoms Of Chronic Rhinitis and The Impact On & Immunology and Center for Clinical & Translational Science, Quality Of Life Creighton University School of Medicine, Omaha, NE, 2Center Jettanong Klaewsongkram, Chulalongkorn University, Bangkok, for Clinical and Translational Science and Department of Biomed- Thailand and Pungjai Mongkolpathumrat, King Chulalongkorn Me- ical Sciences, Creighton University School of Medicine, Omaha, morial Hospital, Bangkok, Thailand NE 475 Clinical Characteristics Of Allergic and In 481 Distinct Patterns and Magnitude Of T Cell Responses Are Asso- Children ciated With Seasonal Exposure To Timothy Grass Allergens Dr. Yong Ju Lee, MD 1, Prof. Kyung Won Kim, MD, PhD 2, Prof. Dr. Pearl Bakhru 1, Carla Oseroff 1, Dr. Veronique M. Schulten 1, Myung Hyun Sohn, MD, PhD2, Prof. Kyu-Earn Kim, MD, PhD 2 Dr. Denise Hinz 1, Victoria Tripple 1, Rafeul Alam, MD, PhD, and Prof. Hae-Ran Lee, MD, PhD3, 1Hallym University Kangnam FAAAAI 2, Dr. David H. Broide, MB ChB FAAAAI 3, Dr. April Sacred Heart Hospital, Seoul, South Korea, 2Department of Pediat- Frazier1, John Sidney 1, Dr. Bjoern Peters 1, Dr. Howard Grey 1 and rics, Severance Children’s Hospital, College of Medicine, Yonsei Dr. Alessandro Sette, Dr. Biol. Sci. 1, 1La Jolla Institute for Allergy University, Seoul, Korea, Seoul, South Korea, 3Hallym University and Immunology, La Jolla, CA, 2National Jewish Health, Denver, Sacred Heart Hospital, Anyang-si, Gyeonggi-do, South Korea CO, 3Department of Medicine, San Diego, CA 482 IgE Production In B Cells Through Up-Regulating CD40L Ex- pression and Mediator Release Via CD1d Expressed In Surface Of Mast Cells Related To Allergic Asthma In Mice Jai Youl Ro 1, Gwan Ui Hong 1, Nam Goo Kim 1 and Young Min Mechanisms of Lymphocyte Function Ahn2, 1Sungkyunkwan University School of Medicine, 2Eulji Uni- versity School of Medicine 3213 483 FOXP3 Epigenetic Signature To Distinguish Between Thymic- Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM and Peripherally-Derived Regulatory T Cells During In Vivo 476 GATA3-Expressing ILC2 Are Selectively Enriched In Allergic Induction Of Immune Tolerance Eosinophilic Nasal Polyposis Dr. Philippe B egin, MD, MSc FRCPC1,2, Dr. Udo Baron, PhD 3, Dr. Hannah H. Walford, MD 1, Dr. Andrew A. White, MD, Dr. Sven Olek, PhD 3, Dr. Rosa Bacchetta, MD, PhD 1,4 and Dr. FAAAAI 2, Dr. Christopher Bergeron, MD 3, Dr. Jacob Husseman, Kari C. Nadeau, MD, PhD, FAAAAI 5, 1Stanford University,

114 J ALLERGY CLIN IMMUNOL Abstracts AB325 VOLUME 133, NUMBER 2

Pediatric Allergy and Immunology, 2Centre Hospitalier Universi- Baker, PhD 3 and Dr. Ray Peebles, MD 4, 1Infectious Diseases; De- taire Ste-Justine, Montreal, QC, Canada, 3Epiontis GmbH, Berlin, partment of Medicine; Vanderbilt University School of Medicine, Germany, 4San Raffaele Telethon Institute for Gene Therapy Nashville, TN, 2Accredited Asthma and Allergy Care, PCS, Louis- (HSR-TIGET), Milan, Italy, 5Pediatric Allergy Immunology, Stan- ville, KY, 3Division of Allergy, Pulmonary and Critical Care Med- ford University, Stanford, CA icine, Vanderbilt University School of Medicine, Nashville, TN, 484 CD4+ and CD8+ T Cells Of Allergic Humans Express Increased Nashville, TN, 4Allergy, Pulmonary, and Critical Care Medicine; Phosphorylated p38 MAP Kinase (p38MAPK), Substance P Department of Medicine; Vanderbilt University School of Medi- Suppresses T Cell Expression Of p38MAPK and Memory IgE cine, Nashville, TN Responses 491 Anti-Viral Innate Immunity Varies Across Different Asthma In- Bryan McCarthy, BS 1, Jonathan I Silverberg, MD, PhD, MPH 1, Seto flammatory Phenotypes M Chice, MS 1, Ankuri Desai, BS 1, Dr.TamarA. Smith-Norowitz, PhD 1, Prof. John W. Upham, MD, PhD, FAAAAI 1, Mrs. Melanie Car- Mark Stewart, MD, PhD 1, Dr. Rauno Joks, MD 2 and Helen G Durkin, roll, BSc1, Prof. Peter Gibson, MD/PhD 2,3, Prof. Ian A. Yang, PhD 1, 1Center for Allergy and Asthma Research at SUNY Downstate, MBBS (Hons) PhD4 and Dr. Jodie Simpson, PhD 2, 1University of Brooklyn, NY, 2Center for Allergy and Asthma Research, State Univer- Queensland, Brisbane, Australia, 2University of Newcastle, New- sity of New York Downstate Medical Center, Brooklyn, NY castle, Australia, 3John Hunter Hospital, Newcastle, Australia, 485 Novel Mechanisms Of Immune Modulation By Alpha-1-Anti- 4The University of Queensland trypsin 492 Effect Of siRNA Inhibition Of Sialyltransferases and Fucosyl- Louise V. Rice 1, Sarah Dimeloe 1, Mun Peak Nyon 2, Imran Haq 3, transferases On Siglec-F Ligand Expression By Epithelial Cells James Irving3, James McDonnell 4, Bibek Gooptu 2,5, Claudia Kem- In Vitro per6 and Catherine M. Hawrylowicz 4, 1MRC and Asthma UK Centre Dr. Maho Suzukawa, MD , National Hospital Oranization, Tokyo for Allergic Mechanisms of Asthma, King’s College London, Lon- Hospital, Dr. Ken Ohta, National Hospital Organization Tokyo Na- don, United Kingdom, 2Institute of Structural and Molecular Biol- tional Hospital, Tokyo, Japan and David Broide, MB ChB, Univer- ogy/Crystallography, London, United Kingdom, 3Cambridge sity of California San Diego, Department of Medicine, Division of Institute for Medical Research, University of Cambridge, Cambridge, Allergy and Immunology United Kingdom, 4MRC and Asthma UK Centre for Allergic Mech- 493 Allergic Airway Inflammation Can Be Regulated By Sema- anisms of Asthma, King’s College London, London, United King- phorin 4C Through Controlling B-Cell Migration dom, 5Division of Asthma, Allergy and Lung Biology, King’s Ms. Di Xue , Mcgill university, Montreal, QC, Canada, Dr. Mar- College London, London, United Kingdom, 6MRC Centre for Trans- ylin Desjardins, MD, Division of Allergy and Clinical Immunol- plantation, Division of Transplantation Immunology and Mucosal Bi- ogy, Department of Paediatrics, McGill University Health Centre, SUNDAY ology, King’s College London, london, United Kingdom Montreal, QC, Canada, Dr. Bruce D. Mazer, MD, FAAAAI, Mon- 486 Prevalence Of Allergic Diseases and/Or Allergic Sensitization treal Children’s Hospital, Montreal, QC, Canada, Dr. Amir Hos- In Children and Adolescents With Type 1 Diabetes Mellitus sein Massoud, PhD, McGill University Health Centre, Montreal, Dr. Hadley Vila-Nova, MD 1, Prof. Angela Spinola-Castro, MD, QC, Canada and Ms. Marianne Beland, MUHC, Montreal, QC, PhD1, Dr. Fab ıola E. Garcia, MD 2 and Prof. Dirceu Sole, MD, Canada PhD3, 1Federal University of S ~ao Paulo, S ~ao Paulo, Brazil, 2Federal 494 Mouse Bone Marrow Derived Mesenchymal Stem Cells Supress UNiversity of S ~ao Paulo, S ~ao Paulo, Brazil, 3Federal University of Airway Inflammation In Both Chronic and Acute Murine Sao Paulo, Sao Paulo, Brazil Asthma Model 487 Microcytosis: A Risk Factor For Asthma and Pulmonary In- Dr. Tunc Akkoc, PhD 1, Mr. Ismail Ogulur, MSc. 1, Ms. Gulben flammation? Gurhan1, Ms. Ayca Aksoy, MSc. 2, Dr. Gokhan Duruksu, PhD 2, Dr. Emily Brigham, MD , Dr. Meredith C. McCormack, MD, Dr. Dr. Deniz Filinte, MD 3, Dr. Erdem Kombak 3, Prof. Isil B. Barlan, Clifford Takemoto, MD and Dr. Elizabeth Matsui, MD, The Johns MD 1 and Prof. Erdal Karaoz, PhD2, 1Marmara University Division Hopkins University School of Medicine, Baltimore, MD of Pediatric Allergy-Immunology, 2Kocaeli University Center for 488 Identification and Cloning Of Active CLC3 Promoter Stem Cell and Gene Therapies Research and Practise, 3Marmara Rohit Gaurav and Devendra K. Agrawal, Department of Biomed- University Department of Pathology ical Sciences and Center for Clinical and Translational Science, 495 Profiling Eicosanoids In Breath Condensates Of Asthmatic and Creighton University School of Medicine, Omaha, NE Healthy Children Dr. Li-chen Chen 1,2, Prof. Jing-Long Huang 1,2, Mrs. AI-Hsuan Wu 1, Prof. Ming-ling Kuo 3 and Prof. Shau-ku Huang4,5, 1Chang- Role of Structural Cells in Mechanisms in Health Gung Memorial Hospital, Taoyuan, Taiwan, 2Chang-Gung Univer- sity, Taoyuan, Taiwan, 3Department of Microbiology and Immunol- and Disease ogy, Institute of Basic Medical Science, Taoyuan, Taiwan, 4Division of Environmental Health and Occupational Medicine, 3214 National Health Research Institutes, Miaoli, Taiwan, 5Johns Hop- Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM kins Asthma and Allergy Center, Baltimore, MD 489 Airway Epithelial Cells Exposed To Alternaria Release IL-18 496 Increased IP-10 Expressions In Nasal Fibroblasts From Patients Independent Of NALP3/Caspase-1 Pathway By Inducing Au- With Refractory Chronic Rhinosinusitis and Asthma tophagy and Nf-Kb Activation Dr. Mamoru , MD 1, Dr. Kota Wada, MD 1, Dr. Tsuyoshi Hiroki Murai, MD, PhD 1, Shintaro Okazaki, MD 1, Hisako Haya- Yoshimura, MD 2, Dr. Daiya Asaka, MD 2 and Prof. Hiroshi Mor- shi, MD 1, Akiko Kawakita, MD 1, Motoko Yasutomi, MD, PhD 1, iyama, MD 2, 1Department of Otorhinolaryngology, Toho University Mitsufumi Mayumi, MD, PhD1, Prof. Sanjiv Sur, MD 2 and Yusei School of Medicine, Tokyo, Japan, 2Department of Otorhinolaryn- Ohshima, MD, PhD1, 1University of Fukui, Fukui, Japan, 2Univer- gology, Jikei University School of Medicine, Tokyo, Japan sity of Texas Medical Branch, Galveston, TX 497 Vitamin D Regulating TGF- b Induced Epithelial-Mesenchymal 490 Generation Of Human Hybridomas Secreting Naturally-Occur- Transition ring IgE MAbs Using Memory B-Cells From Atopic and Asth- Ms. Kimberly Fischer, Creighton University, Omaha and Deven- matic Patients dra K. Agrawal, Department of Biomedical Sciences and Center Dr. Scott A. Smith, MD, PhD 1, Dr. Dennis Horvath, PhD 1, Dr. for Clinical and Translational Science, Creighton University School Charles Steven Smith, MD, FAAAAI 2, Dr. Dawn C. Newcomb of Medicine, Omaha, NE

115 AB326 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

498 Macrophage-Derived Chemokine In Nasal Washes Is Associ- Eun Lee, MD 6, Dr. Song I Yang, MD 7, Dr. Ji-Won Kwon, MD 8, ated With Asthma Exacerbations and Infections With Rhinovi- Dr. Hyung Young Kim, MD 9, Dr. Ju-Hee Seo, MD 10 , Dr. By- rus In Children oung-Ju Kim, MD, PhD 11 , Dr. Hyo-Bin Kim, MD, PhD 12 , Se- Carolyn R. Word, MD 1, Holliday T. Carper, BS 1, Patricia Jorge, Young Oh 4, Dr. Soo-Jong Hong, MD, PhD 7 and Dr. Bong-Seong MD 1, Joshua L. Kennedy, MD 2, Deborah D. Murphy, RN 1, Thomas Kim, MD 13 , 1Johns Hopkins Bloomberg School of Public Health, A.E. Platts-Mills, MD, PhD, FAAAAI 3 and Peter W. Heymann, 2Research Center for Standardization of Allergic Diseases, Asan MD 1, 1University of Virginia, Charlottesville, VA, 2Arkansas Chil- Institute for Life Sciences, University of ulsan College of Medi- dren’s Hospital Research Institute, Little Rock, AR, 3Division of cine, 3Research Center for Standardization of Allergic Diseases, Asthma, Allergy & Immunology, University of Virginia Health Sys- Asan Institute for Life Sciences, University of ulsan College of tem, Charlottesville, VA Medicine, South Korea, 4Department of Food and Nutrition, Col- 499 Application Of Isoraft Single Cell Isolation For Analysis Of Pe- lege of Human Ecology, Kyung Hee University, 5Childhood diatric Bal Macrophages Asthma Atopy Center, Department of Pediatrics, Asan Medical Dr. Neil Alexis, PhD 1, Ms. Heather Wells 2, Dr. Yogesh Saini, Center, University of Ulsan College of Medicine, South Korea, PhD3, Ms. Louisa Brighton 2, Dr. Nancy Allbritton, MD, PhD 4 6Department of Pediatrics, Childhood Asthma Atopy Center, and Dr. Marianne Muhlebach, MD 2, 1Center Environmental Med. Asan Medical Center, University of Ulsan College of Medicine, Asthma/Lung Biology, Chapel Hill, NC, 2Center for Environmental Seoul, South Korea, 7Department of Pediatrics, Childhood Medicine Asthma and Lung Biology, Chapel Hill, NC, 3CF Center Asthma Atopy Center, Research Center for Standization of Aller- SUNDAY UNC Chapel Hill, Chapel Hill, NC, 4Department of Chemistry gic Diseases, Asan Medical Center, University of Ulsan College UNC Chapel Hill, Chapel Hill, NC of Medicine, Seoul, Korea, 8Department of Pediatrics, Seoul Na- 500 7, 4’-Dihydroxyflavone Isolated From Glycyrrhiza Uralensis a tional University Bundang Hospital, Seoul National University Constituent Of ASHMI TM Prevents Dexamethasone Enhance- College of Medicine, Seongnam, South Korea, 9Department of ment Of Eotaxin-1 Secretion By Human Lung Fibroblasts Pediatrics, Kosin University Gospel Hospital, Kosin University Dr. Changda Liu, PhD 1, Dr. Nan Yang, PhD, MS 1, Mr. Ryan P. College of Medicine, Seoul, South Korea, 10 Department of Pedi- Robalino2, Dana Greene 2, Janaki Patel 2, Jiachen Zi 3, Shuwei atrics, Korea Cancer Center Hospital, 11 Department of Pediatrics, Zhang3, Dr. Joseph Goldfarb 2, Hugh A. Sampson, MD, FAAAAI 1, Hae-undae Paik Hospital, Inje University College of Medicine, Dr. Jixun Zhan 3 and Dr. Xiu-Min Li, MD 1, 1Pediatrics, Icahn Busan, South Korea, 12 Department of Pediatrics,Inje University School of Medicine at Mount Sinai, New York, NY, 2Icahn School Sanggye Paik Hospital, Seoul, South Korea, 13 Department of Pe- of Medicine at Mount Sinai, New York, NY, 3Utah State University diatrics, Gangneung Asan Hospital, University of Ulsan College 501 Allergen Sensitivities and Obstruction Indices Among Inner of Medicine City Asthmatic Patients with High IgE (30-700 IU/ml) Vs Ul- 506 Longitudinal Trends Of Food and Environmental Allergen-Spe- tra-High IgE Levels ( >700 IU/ml) cific IgE In Asthmatic Inner-City Children < 4 Years Of Age Jamie Zacharias, MD 1, Dr. Edward S. Schulman, MD, FAAAAI 2, Dr. Keshav Achar, M.B.B.S 1, Yikania Pichardo 2, Margaret A. Rebanta Chakraborty, MD 2, Rozina Ali, DO 1 and Natasha Mehta, Chin, NP 3, Dr. Ramin Nazari, MD 4, Dr. Andrew A. Wiznia, MD 1, 1Division of Internal Medicine, Drexel University College MD 4 and Dr. Gabriele De Vos, MD 5, 1Albert Einstein of Medicine, Philadelphia, PA, 2Division of Pulmonary, Critical College of Medicine, NY, 2Jacobi Medical Center, New York, Care and Sleep Medicine, Drexel University College of Medicine, NY, 3Jacobi Medical Center, NY, 4Albert Einstein College of Philadelphia, PA Medicine, 5Albert Einstein College of Medicine, Bronx, NY 502 Alcohol Exposure and Airway Hyperresponsiveness 507 The Effect Of Human Placental Extract In a Mouse Model Of Dr. Christina Cruz, MD 1, Dr. Thomas B. Casale, MD, FAAAAI 2 Allergic Rhinitis and Peter Oldenburg, PhD 1, 1Creighton University School of Med- Dr. Soo Whan Kim and Dr. Suk-Woo Yang, The Catholic Univer- icine, Omaha, NE, 2Univeristy Of South Florida Morsani College sity of Korea Of Medicine, Tampa, FL 508 Induced Long-Lived Mucosal Mast Cells In The Airways Arise 503 Ragweed Or Dust Mite Antigen-Stimulated Human Primary From Circulating Mast Cell Progenitors Bronchial Epithelial Cells Differentially Express Cytokines In Dr. Lora Georgieva Bankova , Rheumatology/Immunology/Al- Response To Formoterol Or Mometasone Or Their Combina- lergy, Brigham and Women’s Hospital, Boston, MA, Daniel Dwyer, tion Brigham and Women’s Hospital, Dr. Anne Y. Liu, MD, Stanford Dr. Anthony Szema, MD, FAAAAI , SUNY Stony Brook School University School of Medicine, Palo Alto, CA, Dr. Tatiana Jones, of Medicine, East Setauket, NY; Stony Brook University, Stony College of Health Science University of Massachusetts, Lowell, Brook, NY, Dr. Sayyed Hamidi, Stony Brook University School MA, Dr. K. Frank Austen, MD, FAAAAI, Brigham and Women’s of Medicine, Stony Brook, NY, Dr. Ken-Ichi Takemaru, State Uni- Hospital, Harvard Medical School, Boston, MA and Dr. Michael veristy of New York @ Stony Brook, Stony Brook, NY and Ma- Gurish, Brigham and Women’s Hospital/Harvard Medical School, rianne Frieri, MD, PhD, FAAAAI, Medicine and Pediatrics, Boston, MA Nassau University Medical Center, East Meadow, NY; State Uni- 509 Despite Inflammation, No Structural Upper Airway Remodel- versity of NY @ Stony brook, Stony Brook, NY ling In Severe Allergic Rhinitis 504 Release Kinetics Of Soluble ST2 and Proinflammatory Cyto- Dr. Aarif Eifan, MD 1, Dr. Nara Orban, MD 2, Dr. Mikila Jacobson, kines In Allergic Rhinits PhD2 and Prof. Stephen R. Durham, MA MD FRCP 2, 1Imperial Mr. Igor Stenin 1, Mr. Ralf Baumann 1, Mr. Matthaeus Rabaszow- College London, United Kingdom, 2Imperial College London, Lon- ski1, Dr. Kathrin I. M. Scheckenbach, MD 1, Mr. Pascal Werming- don, United Kingdom haus1 and Dr. Martin Wagenmann, MD, FAAAAI 2, 1Department 510 Ozone Inhalation Induces Epithelial IL-33 and Thymic Stromal of Otorhinolaryngology, Head and Neck Surgery, Heinrich-- Lymphopoietin (TSLP) and Leads To Eosinophilic Airway In- University Duesseldorf, Germany, 2Henrich Heine University, flammation Dusseldorf,€ Germany Stephanie Kubala 1,2, Moyar Q. Ge 2, Imre Redai 2, Monica Soni 2,3, 505 Interaction Between Dietary Antioxidants and Passive Smoking Dr. Bei Chen, MD 2, Dr. Qi Yang, PhD 2, Dr. Avinash Bhandoola, On The Risk Of Asthma Modified By GSTP1(rs1695) Polymor- MBBS PhD2, Dr. Noam A. Cohen, MD, PhD 2 and Dr. Angela phism Haczku, MD, PhD, FAAAAI 2, 1Temple University School of Med- Dr. Young-Hwa Song, MD, MPH Candidate 1, Hye Lim Shin 2, icine, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, Seo Ah Hong 3, Sung-Ok Kwon 4, Dr. Young Ho Jung, MD 5, Dr. PA, 3Georgetown University

116 J ALLERGY CLIN IMMUNOL Abstracts AB327 VOLUME 133, NUMBER 2

Allied Health Oral Abstract Luncheon Brigham and Women’s Hospital, Division of Rheumatology, Immu- nology and Allergy, Boston, MA 3520 517 Relationships Between The New Biomarkers Induced By Inter- Sunday, March 2nd, 2014, 12:15 PM - 1:30 PM leukin-13 and Bronchial Hyperresponsiveness In Asthmatic Children: Periostin and Squamous Cell Carcinoma-Related An- 511 Clinical Efficacy Of Subcutaneous and Sublingual Immunother- tigens apy In Asthma and Rhinitis Children Sensitized To House Dust 1 2 1,2 1,3 1 Prof. Heysung Baek, MD, PhD , Prof. Kenji Izuhara, MD, PhD Mite Min-Ju Kim , Eun Lee , Keun-Mi Park , Keum-Hee 1 1 1 1,3 1,4 2 and Dr. Jeong-Sub Yoo , Department of Pediatrics, Hallym Uni- Hwang , Young-Ho Jung , Song-Yi Yang , Jae-Eun Lee , Hee- versity College of Medicine, Seoul, South Korea, 2Saga Medical Kyeong Kim 2, Hye-yeong Lee 2, Jin-ho Yu 1 and Prof. Soo-Jong 1,3 1 School, Saga, Japan Hong, MD. PhD , Childhood Asthma Atopy Center, Department 518 Exhaled Nitric Oxide Performance Compared To Methacholine of Pediatrics, Asan Medical Center, University of Ulsan College of Challenge In Asthma Medicine, South Korea, 2Department of Children’s Hospital Nurs- 3 Andrew Nickels, MD , Dr. Kaiser G. Lim, MD, FAAAAI, Dr. Paul ing, Asan Medical Center, South Korea, Research Center for Stan- Scanlon, MD and Kenneth Parker, Mayo Clinic, Rochester, MN dardization of Allergic Disease, University of Ulsan College of 4 519 Serum Interleukin 13 (IL-13) and Surfactant Protein D (SP-D) Medicine, Seoul, Korea, Research Center for Standardization of Expression Is Differentially Associated With Disease Status In Allergic Disease, University of Ulsan College of Medicine, Seoul, Pediatric Asthma Patients Korea, South Korea Dr. Vasiliki Gemou-Engesaeth, MD, PhD 1, Dr. N Laliotou, MD 1, 512 A Patient-Reported Symptom-Based Predictor Of Objective Si- Prof. Chris J. Corrigan, MD, PhD, FAAAAI 2, Prof. George P. nus Inflammation 1 3 1 2 Chrousos, MD, PhD and Dr. Angela Haczku, MD, PhD, FAAAAI , Ms. Alcina K. Lidder, BA , Dr. Rakesh Chandra, MD , Dr. David 1National & Kapodistrian University of Athens, Greece, 2King’s Conley, MD 1, Dr. Stephanie Shintani-Smith, MD 1, Dr. Anju T. Pe- 3 3 College London School of Medicine, London, United Kingdom, ters, MD, FAAAAI , Dr. Leslie C. Grammer, MD, FAAAAI , Dr. 3 1 4,5 University of Pennsylvania, Philadelphia, PA Robert C. Kern, MD , Dr. Brian Schwartz, MD and Dr. Bruce 520 Correlation Of Exhaled Breath Temperature With Age In K. Tan, MD 1, 1Department of Otolaryngology, Northwestern Uni- 2 Chronic Respiratory Diseases versity Feinberg School of Medicine, Chicago, IL, Northwestern 1 2 3 Dr. Radoslaw Gawlik, MD , Dr. Malgorzata Rajzer-Wrobel , Dr. University, Chicago, IL, Department of Medicine, Division of Al- Dariusz Ziora2 and Prof. Lawrence M. DuBuske, MD, FAAAAI 3, lergy-Immunology, Northwestern University Feinberg School of 1 2 4 Silesian Medical University, Katowice, Poland, Silesian Medical Medicine, Chicago, IL, Center for Health Research, Geisinger University, Poland, 3George Washington University School of Med- 5 SUNDAY Clinic, Danville, PA, Johns Hopkins Bloomberg School of Public icine, Washington, DC Health, Baltimore, MD 513 Healthcare Providers’ Perception Versus Reality In Patient Concerns About Starting Subcutaneous Immunoglobulin Ms. Carla M. Duff, CPNP MSN 1, Ms. Annette R. Zampelli, NP 2 and Dr. Ann Bullinger, PharmD 2, 1University of South Florida, Immune Mechanisms in Atopy Tampa, FL, 2CSL Behring, LLC, King of Prussia, PA 514 Anaphylaxis During Obstetric Surgery In Latex Allergic Pa- 3602 tients Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM Dr. Nana Jinjolava, MD 1, Dr. *Mili Shum, MD 2, Dr. Keshav 521 Peripherally Induced Foxp3+ Regulatory T Cells Mediates The Achar1, Dr. Ren Zhen 1 and Dr. Elina Jerschow, MD, M.Sc. 3, 1Albert Immunomodulatory Effect Of Intravenous Immunoglobulin In Einstein College of Medicinen, 2Montefiore Medical Center, Bronx, An Experimental Model Of Allergic Airway Disease NY, 3Albert Einstein College of Medicine/Montefiore Medical Cen- Dr. Amir Hossein Massoud, PhD 1,2, Mr. Gabriel N. Kaufman, ter, Bronx, NY MSc1,2, Dr. Ciriaco Piccirillo, PhD 2 and Dr. Bruce D. Mazer, 515 The Impact Of Legislation On Illinois School Nurses MD, FAAAAI 1,3, 1Meakins-Christie Laboratories, Research Insti- Ms. Christine Szychlinski, APN, CPNP1, Mrs. Katherine A. tute - McGill University Health Centre, Montreal, QC, Canada, Schmeissing, MS, R.N.2, Dr. Jacqueline Pongracic, MD, FAAAAI 2 2McGill University Health Centre, Montreal, QC, Canada, 3Mon- and Dr. Anne Marie Singh, MD 3, 1Northwestern University Fein- treal Children’s Hospital, Montreal, QC, Canada berg School of Medicine, Ann & Robert H. Lurie Children’s Hos- 522 Differential DNA Methylation In Mothers Increases The Prev- pital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children’s alence Of Atopic Dermatitis In Their Offspring Hospital of Chicago, Chicago, IL, 3Division of Allergy & Immunol- Dr. Pia J. Hauk, MD 1, Mrs. Anna Forssen, MS 1, Dr. Brent Peder- ogy, Department of Pediatrics, Northwestern University Feinberg sen, PhD2, Dr. Matthew Strand, PhD 1, Mrs. Lindsay Munoz, BA 1, School of Medicine, Ann & Robert H. Lurie Children’s Hospital Dr. Michaela Schedel, PhD 1, Dr. Anne Lynch, MD, MSPH 2, Dr. of Chicago, Chicago, IL Virginia Winn, MD, PhD 2, David A. Schwartz, MD 3 and Dr. Erwin W. Gelfand, MD, FAAAAI 1, 1National Jewish Health, Denver, CO, 2University of Colorado Denver, Aurora, CO, 3University of Colo- rado Denver School of Medicine, Aurora, CO Biomarkers 523 Hypereosinophilia In Children and Adults: A Retrospective Comparison 3601 Kelli Williams, MD, M.P.H. , JeanAnne Ware, CRNP, Annalise Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM Abiodun, RN, Paneez Khoury, MD and Dr. Amy D. Klion, MD, Na- 516 Socio-Demographic and Environmental Correlates Of Exhaled tional Institutes of Health, Bethesda, MD Nitric Oxide Levels 524 Interleukin 35 Modulates TSLP, IL-25 and IL-33 Primed Den- Dr. Lakiea S Wright, MD MAT , Brigham and Women’s Hospital dritic Cells and Inhibits Naive T Cell Differentiation and Grass Division of Rhematology, Immunology & Allergy, Boston, MA; Pollen-Specific T Cell Proliferation Boston Children’s Hospital Division of Allergy and Immunology, Natalia C Couto-Francisco 1, Dr. Tomokazu Matsuoka 2,3, Ms. Ra- Boston, MA, Dr. Wanda Phipatanakul, MD, MS, FAAAAI, Boston chel Yan, RN 3, Prof. Stephen R. Durham, MA MD FRCP 1 and Dr. Children’s Hospital, Boston, MA and Jessica Rabe Savage, MD , Mohamed H. Shamji, BSc MSc PhD 4, 1Imperial College London,

117 AB328 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

London, United Kingdom, 2Medical Research Council and Asthma 530 Sensitization To Occupational Allergens and Allergic Diseases UK Centre for Allergic Mechanisms of Asthma, UK, United King- In Workers Of 5 Havana Bakeries dom, 3Imperial College London, United Kingdom, 4Imperial Col- Dr. Mirta Alvarez, MD 1, Dr. Alexis Labrada, PhD 2, Raul Lazaro lege London, South Kensington, United Kingdom Castro Almarales, MD 3, Mrs. Yaquel ın Leyva 1, Mr. Victor R 525 Fc-Gamma-Receptor-IIb Is Required For The Immunomodula- Meli4, Dr. Humberto Barata 4 and Dr. Miguel Hinojosa 5, 1Calixto tory Actions Of Intravenous Immune Globulin In An Antigen- Garcıa University Hospital, Cuba, 2National Center of Bioproducts, Driven Murine Model Of Allergic Airways Disease Havana, Cuba, 3National Center of Bioproducts, Cuba, 4Diater Lab- Mr. Gabriel N. Kaufman, MSc 1, Dr. Amir Hossein Massoud, oratories, Argentina, 5Ramon y Cajal Hospital, Spain PhD1, Dr. Ciriaco A. Piccirillo, PhD 2 and Dr. Bruce D. Mazer, MD, FAAAAI 1,3, 1Meakins-Christie Laboratories, Research Insti- tute - McGill University Health Centre, Montreal, QC, Canada, 2Centre for the Study of Host Resistance, Research Institute - Drug Allergy McGill University Health Centre, Montreal, QC, Canada, 3Montreal Children’s Hospital, Montreal, QC, Canada 3604 Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 531 Safety Of Propofol Use In Patients With Food Allergies

SUNDAY Dr. Harshna Mehta, MD , The Icahn School of Medicine at Mount Leonard Bernstein Session on Occupational Sinai, New York, NY and Dr. Mirna Chehade, MD, MPH, Icahn Allergic Diseases School of Medicine at Mount Sinai, New York, NY; Mount Sinai Center of Eosinophilic Disorders, Jaffe Food Allergy Institute, 3603 Mount Sinai School of Medicine, New York, NY Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 532 Risk Stratification Protocol For Carboplatin and Oxaliplatin Hypersensitivity Reactions With Repeat Skin Testing Improves 526 Endotoxin In Size-Specific Airborne Particles Induces Differen- Care tial Nitrative Stress In Human Bronchoepithelial Cells Dr. Alberta L. Wang, MD 1, Dr. Sarita U. Patil, MD 2, Dr. Aidan Umesh Singh1, Dr. Jonathan A. Bernstein, MD, FAAAAI 1, Kristin Long, MD, FAAAAI 2 and Dr. Aleena Banerji, MD 2, 1Department Luther2, Lauren Haar 2 and Dr. W. Keith Jones, PhD 2, 1Division of of Medicine, Massachusetts General Hospital, Harvard Medical Immunology Allergy & Rheumatology, University of Cincinnati School, Boston, MA, 2Division of Rheumatology, Allergy, and Im- Medical Center, Cincinnati, OH, 2Department of Medicine and munology, Department of Medicine, Massachusetts General Hospi- Pharmacology & Cell Biophysics, University of Cincinnati Medical tal, Harvard Medical School, Boston, MA Center, Cincinnati, OH 533 Added Value Of Skin Testing In Hypersensitivity Reactions To 527 High Rates Of Sensitization To Selected Metals and Bone Ce- Taxanes ment In Joint Replacement Failure Patients and Preoperative Dr. Matthieu Picard, MD 1, Dr. Leyla Pur, MD 1, Dr. Joana Caiado, Evaluations MD 1, Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI 2, Dr. Vio- Dr. Karin A. Pacheco, MD, MSPH FAAAAI , Dr. Annyce Mayer, leta Galv~ao, MD 1 and Dr. Mariana C. Castells, MD, PhD, MD, MSPH, Ms. Samantha Erb, MS, Dr. Lata Shirname-More, PhD FAAAAI 1, 1Division of Rheumatology, Allergy and Immunology, and Dr. Lisa A. Maier, MD, MSPH FCCP, National Jewish Health, Department of Medicine, Brigham and Women’s Hospital, Harvard Denver, CO Medical School, Boston, MA, 2Clinical Imunnology and Allergy 528 Component Resolved Diagnosis In Baker’s Asthma Division, University of Sao Paulo, Boston, MA Ms. Cristina Gomez-Casado 1, Dr. Paloma Campo, MD, PhD 2, Dr. 534 Risk Stratification For Paclitaxel-Induced Hypersensitivity Re- Maria Garrido, PhD3, Ms. C Pereira 4, Dr. Arantxa Palacin, PhD 1, actions Improves Quality Of Care Dr. La Rivas 4, Dr. M Catarino 5, Dr. Ana Aranda, PhD 6, Maria Luisa Dr. Timothy P. Lax, MD , Dr. Aleena Banerji, MD, Dr. Johnson T. Macias6, Dr. Alicia Armentia, MD, PhD 7, Dr. S. Quirce, MD, PhD 8, Wong, MD, FAAAAI, Dr. Michael T. Wilson, MD, PhD and Dr. Ai- Dr. Miguel Blanca, MD, PhD 2 and Araceli Diaz Perales1, 1Centre dan Long, MD, FAAAAI, Division of Rheumatology, Allergy, and for Plant Biotechnology and Genomics (UPM-INIA), Madrid, Immunology, Department of Medicine, Massachusetts General Spain, 2Allergy Service, Carlos Haya Hospital, M alaga, Spain, Hospital, Harvard Medical School, Boston, MA 3Plant Biotechnology Institute (UPM-INIA), Madrid, Spain, 4Mo- 535 Healthcare Utilization and Serious Infection Prevalence Associ- lecular Evolution Laboratory, Astrobiology Centre (INTA-CSIC), ated With Penicillin ‘‘Allergy’’ In Hospitalized Patients: A Co- Madrid, Spain, 5Faculty of Pharmacy, University of Lisbon, Lisbon, hort Study Portugal, 6Research Laboratory, Carlos Haya Hospital-FIMABIS, Dr. Eric M. Macy, MD, FAAAAI , 5th Floor, SCPMG-Kaiser Per- Malaga, Spain, 7Valladolid University, Valladolid, Spain, 8Hospital manente San Diego, San Diego, CA and Richard Contreras, MS, La Paz Institute for Health Research (IdiPaz), Allergy department., Kaiser Permanente Health Care Program, Department of Research Madrid, Spain and Evaluation, Pasadena, CA 529 Endotoxin Exposure May Protect Against The Development Of Rhinoconjunctivitis and Respiratory Symptoms In Non-Atopic Individuals With Occupational Exposure To Mice Dr. Sharon K. Ahluwalia, MD 1,2, Dr. Roger Peng, PhD 3, Mr. Charles Aloe, MPH2, Wayne G. Shreffler, MD, PhD, FAAAAI 4,5, Oral Immunotherapy for Food Allergy Mary Krevans, RN 6, Karol A. Hagberg, BSN FNP 6, Dr. Peter S. Thorne, PhD7, Kenneth Walsh 8 and Dr. Elizabeth Matsui, MD 9, 3605 1Children’s National Medical Center, Washington, DC, 2Johns Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM Hopkins University School of Medicine, Baltimore, MD, 3Johns 536 Length Of Avoidance Period Following Peanut Oral Immuno- Hopkins School of Public Health, Baltimore, MD, 4Massachusetts therapy Influences Effector Cell Suppression and Clinical Out- General Hospital, Boston, MA, 5Harvard Medical School, Boston, comes Michael D. Kulis Jr., PhD , Dr. Rishu Guo, PhD, Brian P. MA, 6The Jackson Laboratory, Bar Harbor, ME, 7 University of Vickery, MD, FAAAAI, Pamela H. Steele, MSN CPNP AE-C, Ed- Iowa, Iowa City, IA, 8The Jackson Laboratories, ME, 9The Johns win Kim, MD, MS and A. Wesley Burks, MD, FAAAAI, University Hopkins University School of Medicine, Baltimore, MD of North Carolina at Chapel Hill, Chapel Hill, NC

118 J ALLERGY CLIN IMMUNOL Abstracts AB329 VOLUME 133, NUMBER 2

537 Basophil Hyporesponsiveness To Peanut Following Immuno- 545 Misuse Of Medical Devices Among Patients In a Tertiary Care therapy May Be Transient and Correlates With Clinical Re- Allergy/Immunology Practice sponse Dr. Rana S. Bonds, MD, FAAAAI , University of Texas Medical Dr. Mark Gorelik, MD 1, Dr. Satya Narisety, MD 1, Kristin Chiches- Branch, Galveston, TX and Dr. Aasia I. Ghazi, MD, Allergy and ter, MS 1, Anja Bieneman, BS 1, Corinne Keet, MD, MS 2, Robert A. Asthma Specialists, Plano, TX Wood, MD, FAAAAI 2, Dr. John T. Schroeder, PhD 1 and Pamela Frischmeyer Guerrerio1, 1Johns Hopkins University School of Med- icine, 2Johns Hopkins University Medical Center, Baltimore, MD 538 Safety Of Pediatric Peanut Oral Immunotherapy Is Compli- cated By High Adverse Event Rates Mechanisms of Immunotherapy Yamini Virkud, MD, MA 1, Brian P. Vickery, MD, FAAAAI 2, Pa- mela H. Steele, MSN CPNP AE-C 2, Janet S. Kamilaris, RN 3 and A. 3607 Wesley Burks, MD, FAAAAI 2, 1Duke University, Durham, NC, Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 2University of North Carolina, Chapel Hill, NC, 3Carolinas Health 546 B Cells and Plasma Cells Populations Suffer Changes Along Care System, Charlotte, NC The Time After Dermatophagoides Pteronyssinus Specific Im- 539 Course and Outcome Of Patients With Asthma During Oral munotherapy Immunotherapy To Cow’s Milk Protein Dr. Enrique G omez, PhD1, Dr. Tah ıa Fern andez, PhD2, Dr. Inmacu- Dr. Arnon Elizur, MD 1,2, Dr. Michael Goldberg, MD, PhD 1, Dr. lada Do na,~ MD, PhD3, Dr. Francisca G omez, MD, PhD3, Mrs. Luisa Michael Levy, MD, FAAAAI 1, Dr. Liat Nachshon, MD 1 and Prof. Galindo, RN 3, Ms. Lidia Melendez, Lab. Tech. 4, Dr. Miguel Blanca, Yitzhak Katz, MD, FAAAAI 1,2, 1Assaf Harofeh, Zerifin, Israel, MD, PhD3, Dr. Cristobalina Mayorga, PhD 5 and Dr. Maria Jos e Jose 2Tel Aviv University, Tel Aviv, Israel Torres, MD, PhD 3, 1Research Laboratory for Allergic Diseases, Hos- 540 B-Fahf-2 Pretreatment Reduces OIT Adverse Reactions and pital Regional Universitario de Malaga - IBIMA, M alaga, Spain, 2Re- Improves Outcomes In a Murine Model Of Multiple Nut Al- search Laboratory - FIMABIS Foundation, M alaga, Spain, 3Allergy lergy Service, Carlos Haya Hospital, Malaga, Spain, 4Research Labora- Dr. Xiu-Min Li, MD , Dr. Ying Song, MD, Dr. Changda Liu, PhD, tory, Carlos Haya Hospital-FIMABIS, Malaga, Spain, 5Research Mr. Ilan Goldberg, Hugh A. Sampson, MD, FAAAAI and Dr. Ka- Laboratory, Carlos Haya Hospital-FIMABIS, M alaga, Spain mal D. Srivastava, PhD, Pediatrics, Icahn School of Medicine at 547 A Subset Of Novel Timothy Grass Antigens Is Associated With Mount Sinai, New York, NY Marked Th1/Th2 Shifts Following Specific Immunotherapy 1 1 1

Dr. Veronique M. Schulten , Victoria Tripple , John Sidney , Dr. SUNDAY Jason Greenbaum1, Dr. April Frazier 1, Rafeul Alam, MD, PhD, FAAAAI 2, Dr. David H. Broide, MB ChB FAAAAI 3, Dr. Howard Grey1, Dr. Bjoern Peters 1 and Dr. Alessandro Sette, Dr. Biol. Adherence Sci.1, 1La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2National Jewish Health, Denver, CO, 3Department of Medi- 3606 cine, San Diego, CA Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 548 Interleukin IL-27+ Dendritic Cells Modulate Ex-Vivo Th2 Re- 541 Adherence Documentation During Asthma Encounters At a Pe- sponses In a Pdl-1-Dependent Manner and Increase In-Vivo diatric Tertiary Care Referral Center Following Grass Pollen Immunotherapy Kara J. Wada, MD , Nationwide Children’s Hospital and The Ohio Dr. Tomokazu Matsuoka 1, Ms. Rachel Yan, RN 2, Dr. Guy W State University, Columbus and David R. Stukus, MD, FAAAAI, Scadding, MD 2, Prof. Stephen R. Durham, MA MD FRCP 3 and Nationwide Children’s Hospital, Columbus, OH Dr. Mohamed H. Shamji, BSc MSc PhD 4, 1Medical Research 542 High-Risk Asthma Multidisciplinary Care Clinic Adherence Council and Asthma UK Centre for Allergic Mechanisms of Linked To Asthma Control Test (ACT) Score Improvement Asthma, UK, United Kingdom, 2Imperial College London, United Dr. Bradley A. Locke, DO 1, Dr. Pippa Simpson, PhD 1, Mrs. Tina Kingdom, 3Imperial College London, London, United Kingdom, Bromberger, RN, BSN, AE-C 2, Mrs. Melodee Nugent, MA 1, Mrs. 4Imperial College London, South Kensington, United Kingdom Sara A. Lowe, NP 1, Dr. Juan Ruiz, MD 1, Dr. Patricia Marik, 549 Local ‘Protective’ IgG4 Antibodies In Nasal Fluid Are Elevated PsyD2, Dr. Jacquelyn Smith, PhD 2, Dr. Joshua A. Steinberg, MD 1 Following Grass Pollen Immunotherapy and Dr. Dorothy S. Cheung, MD, FAAAAI 1, 1Medical College of Jinjin Zhang1, Dr. Esther Steveling 2, Ms. Rachel Yan, RN 2, Dr. Wisconsin, Milwaukee, WI, 2Children’s Hospital of Wisconsin, Aarif Eifan, MD 2, Rebecca Parkin 3, Dr. Guy W Scadding, MD 2, Milwaukee, WI Dr. Mohamed H. Shamji, BSc MSc PhD 4 and Prof. Stephen R. Dur- 543 Understanding Asthma Medical Nonadherence In Adult and ham, MA MD FRCP 1, 1Imperial College London, London, United Pediatric Populations Kingdom, 2Imperial College London, United Kingdom, 3Imperial Joyce Xiang Wu Lee, MD 1, Henry Wojtczak, MD 2, Allan M. College London, London, 4Imperial College London, South Ken- Wachter, MD 3, Martin Lee, PhD 4, Lisa , RN 3, Diana Chen 3 sington, United Kingdom and Joseph S. Yusin, MD, FAAAAI 5, 1Allergy/Immunology, VA 550 Grass Pollen Immunotherapy: Impaired Allergen-Induced Na- Greater Los Angeles Health Care System, Los Angeles, CA, 2Naval sal and Cutaneous Responses Correlate With Overall Seasonal Medical Center San Diego, San Diego, CA, 3Foundation for Symptom Scores and Are Associated With Suppressed Local Asthma Research and Intervention, Phoenix, AZ, 4UCLA School Th2 Cytokines In Nasal Fluid of Public Health, Los Angeles, CA, 5VA Greater Los Angeles Dr. Guy W Scadding, MD 1, Dr. Aarif Eifan, MD 1, Dr. Mongkol Health Care System, Los Angeles, CA Lao-Araya, MD 1, Dr. Martin J. Penagos Paniagua, MD 1, Ms. 544 Improved Education and Self-Management In Children and Shun Yan Poon 1, Dr. Esther Steveling 1, Ms. Andrea Goldstone, Adolescents With Asthma Using a Personalized Smartphone RN 1, Ms. Rachel Yan, RN 1, Ms. Amy Switzer 1, Dr. Deborah Phip- Application pard2, Dr. Mohamed H. Shamji, BSc MSc PhD 3 and Prof. Stephen David R. Stukus, MD, FAAAAI 1,2, Gary Phillips, M.A.S. 1 and Na- R. Durham, MA MD FRCP 4, 1Imperial College London, United beel Farooqui, MD 1,2, 1Wexner Medical Center at The Ohio State Kingdom, 2Immune Tolerance Network, 3Imperial College London, University, Columbus, OH, 2Nationwide Children’s Hospital, Co- South Kensington, United Kingdom, 4Imperial College London, lumbus, OH London, United Kingdom

119 AB330 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Mechanisms of Eosinophil-Driven Disease 557 Analysis Of Severe Asthma Phenotypes By Using High-Resolu- tion Computed Tomography: Relation To Clinical Assessment Sujeong Kim1, Kwang-Nam Jin 2, Chang Hyun Lee 2, Prof. So-Hee 3608 3 4 1 Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM Lee , Jae-Won Jung , Prof. Woo-Jung Song, M.D. , Prof. Hye- Ryun Kang1, Kyung-Up Min 1 and Prof. Sang Heon Cho, MD, 551 IL-4 and IL-13 Differentially Regulate TLR-Induced Eosino- PhD3, 1Department of Allergy and Clinical Immunology, Seoul Na- phil-Basophil Differentiation Of Cord Blood CD34+ Progenitor tional University College of Medicine, Seoul, South Korea, 2De- Cells 1 1 partment of Radiology, Seoul National University College of Dr. Pia Reece, PhD , Dr. Roma Sehmi, PhD FAAAAI and Ju- Medicine, Seoul, South Korea, 3Department of Internal Medicine, dah Aryeh Denburg, MD, FRCPC, FAAAAI 2, 1McMaster Univer- 2 Seoul National University College of Medicine, Seoul, South Ko- sity, Hamilton, ON, Canada, Division of Clinical Immunology rea, 4Inje university ilsan paik hospital, Seoul, South Korea and Allergy, Department of Medicine, McMaster University, 558 Associations Between The Expression Of Corticosteroid Regu- ON, Canada lated Genes By Peripheral Blood Mononuclear Cells (PBMCs) 552 Basophils Act As a Cellular Switch to Drive Eosinophilic In- In Children From The NIH/NIAID Sponsored Asthma Pheno- flammation after IgE Activation types In The Inner City (APIC) Study Dr. Laurence E. Cheng, MD, PhD , University of California, San Dr. Elena Goleva, PhD 1, Leisa P. Jackson, BS 1, Baomei Shao, BS 2, Francisco Medical Center, San Francisco, CA and Prof. Richard Zheng Hu, BS 2, Dr. Michelle A. Gill, MD, PhD 2, Andrew H. Liu, SUNDAY M. Locksley, MD, University of California, San Francisco, MD 1 and Donald Y.M. Leung, MD, PhD, FAAAAI 1, 1National HHMI, San Francisco, CA Jewish Health, Denver, CO, 2UT Southwestern Medical Center, 553 The SNARE VAMP-7 Contributes To Eosinophil Degranula- Dallas, TX tion, In Vivo 559 Bronchial Mast Cell Markers and Clinical Asthma Severity In Dr. Paige Lacy, PhD FAAAAI 1, Dr. Lian Willetts, PhD 1, Dr. Eliza- 2 2 2 Steroid Refractory Asthmatics beth Jacobsen, PhD , Dr. Rachel Condjella, PhD , Ms. Katie Zellner , 1 2 2 2 2 Dr. Mandeep Hundal, M.D. , Dr. Katherine N. Cahill, MD , Rob- Dr. Sergei Ochkur, PhD , Mr. Hui Lou , Mr. Will LeSuer , Mr. John 1 1 1 1 2 2 ert Pedicini , Allison Crosby-Thompson , Stefanie Dutile , Usha Kim, MSc , Ms. Cheryl Protheroe , Mr. Ralph Pero , Dr. James J. 2 3 3 2 Govindarajulu, PhD , Dr. Kartik Shenoy, M.D. , Dr. Mark Drans- Lee, PhD , Dr. Nancy A. Lee, PhD and Dr. Redwan Moqbel, PhD 4 5 6 4 1 field , Dr. Emily DiMango , Dr. Serpil C. Erzurum, M.D. , Dr. FRCPath FAAAAI , University of Alberta, Edmonton, AB, Canada, 7 8 2 3 Mario Castro, MD, MPH , Dr. Nizar N. Jarjour, MD , Dr. Howard Mayo Clinic Arizona, Scottsdale, AZ, Mayo Clinic of Arizona, 2 2 4 Katz, PhD , Dr. Joshua A. Boyce, MD, FAAAAI and Dr. Elliot Is- Scottsdale, AZ, University of Manitoba, Winnipeg, MB, Canada rael, MD, FAAAAI 1, 1Brigham and Women’s Hospital, Boston, 554 Microbiota Regulates Eosinophils In The Small Intestine 2 1 1 MA, Brigham and Women’s Hospital, Division of Rheumatology, Dr. Rodrigo Jimenez-Saiz, PhD , Mrs. Tina Walker-Fattouh , 3 1 1 Immunology and Allergy, Boston, MA, Temple University School Mrs. Melissa E. Gordon, MSc , Mr. Waleed S. Ahmed , Ms. 4 5 1 1 1 of Medicine, University of Alabama School of Medicine, AL, Co- Breanne Dale , Mr. Talveer S. Mandur , Mr. Joshua Kong , 6 1 2 lumbia University, New York, NY, Department of Pathobiology, Mr. Derek K. Chu , Dr. Roland Kolbeck, PhD , Dr. Alison A. 7 2 3 Cleveland Clinic, Washington University School of Medicine, St. Humbles, PhD , Dr. Elena F. Verdu, MD, PhD and Dr. Manel 8 1 1 Louis, MO, University of Wisconsin School of Medicine and Pub- Jordana, MD, PhD , McMaster Immunology Research Centre lic Health, Madison, WI (MIRC), McMaster University, Hamilton, ON, Canada, 2Medi- 3 560 Antagonistic Effects Of Ozone (O3) Exposure and Glucocorti- mmune LCC, Gaithersburg, MD, Farcombe Family Digestive coid Treatment On Airway Hyperresponsiveness (AHR) and Health Research Institute, McMaster University, Hamilton, ON, Surfactant Protein D (SP-D) Production In Mice Canada Moyar Q. Ge 1,2, Monica Soni 1, Imre Redai 1, Blerina Kokalari 1, Dr. 555 The Airway Mucins Muc5b and Muc4 Are Endogenous Ligands Angela Haczku, MD, PhD, FAAAAI 1 and Zhilong Jiang1, 1Univer- For Siglec-F and Induce Mouse Eosinophil Death 2 1 2 sity of Pennsylvania, Philadelphia, PA, National University of Sin- Takumi Kiwamoto, MD, PhD , Toshihiko Katoh, PhD , Christo- gapore, Singapore, Singapore pher Evans, PhD 3, Mary E. Brummet, MS 1, Sherry Hudson, MS 1, Zhou Zhu, MD, PhD1, Michael Tiemeyer, PhD 2 and Bruce S. Boch- ner, MD, FAAAAI 1, 1Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Complex Carbohydrate Research Center, University of Georgia, Advances in Primary Immunodeficiencies Athens, GA, 3Division of Pulmonary Medicine, University of Col- orado School of Medicine, Denver, CO 3802 Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM 561 Impaired Glycosylation Due To Autosomal Recessive PGM3 Mutations Results In Atopy, Immune Deficiency, Autoimmu- Featured Poster Session nity, and Neurocognitive Impairment Dr. Joshua D. Milner, MD 1, Dr. Jonathan J. Lyons, MD 1, Dr. Yu Zhang, PhD2, Dr. Xiaomin Yu, PhD 1, Dr. Shrimati Datta, PhD 1, Ian T. Lamborn, BSc 2, Matthew R. Biancalana, BSc 3, Lynne A. Best of ADT Wolfe, CRNP 4, Thomas DiMaggio, BSN 2, Helen F. Matthews, BSN3, Dr. Sarah M. Kranick, MD 5, Dr. Kelly D. Stone, MD, 3801 PhD, FAAAAI 1, Dr. Steven M. Holland, MD 6, Dr. Daniel S. Reich, Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM MD, PhD7, Dr. Jason D. Hughes, PhD 8, Dr. Huseyin Mehmet, 556 Impact Of Asthma Exacerbations On Lung Function In a Large PhD8, Dr. Joshua McElwee, PhD 8, Dr. Hudson H. Freeze, PhD 9, Cohort Of Patients With Severe Or Difficult-To-Treat Asthma Dr. Alexandra F. F. Freeman, MD 6 and Dr. Helen C. Su, MD, Dr. Theodore A. Omachi 1, Dr. Tmirah Haselkorn 1, Dave P. Miller 2 PhD2, 1Laboratory of Allergic Diseases, NIAID/NIH, Bethesda, and Dr. William J. Calhoun, MD, FAAAAI 3, 1Genentech, Inc., South MD, 2Laboratory of Host Defenses, NIAID/NIH, Bethesda, MD, San Francisco, CA, 2ICON Clinical Research, 3Allergy And Immunol- 3Laboratory of Immunology, NIAID/NIH, Bethesda, MD, 4Undiag- ogy, University of Texas Medical Branch, Galveston, TX nosed Diseases Program, NHGRI/NHI, Bethesda, MD, 5Medical

120 J ALLERGY CLIN IMMUNOL Abstracts AB331 VOLUME 133, NUMBER 2

Neurology Branch, NINDS/NIH, Bethesda, MD, 6Laboratory of Biotechnologies, Inc., Charlottesville, VA, 2University of Virginia, Clinical Infectious Diseases, NIAID/NIH, Bethesda, MD, 7Neuro- Charlottesville, VA, 3University of South Carolina, Columbia, SC immunology Branch, NINDS/NIH, Bethesda, MD, 8Merck Re- 569 Development Of IgE Against a Cimex Lectularius Allergen Af- search Laboratories, Merck & Co. Inc., Boston, MA, 9Sanford ter Being Bitten By Bed Bugs Was Common Among Children In Burnham Medical Research Institute, La Jolla, CA NYC 562 Expansion Of Circulating T Follicular Helper Cells In CVID Adnan Divjan1, Dr. Jason B. Price, MD 2, Dr. Luis M. Acosta, MD 1, Patients With Autoimmune Cytopenias Prof. Andrew Rundle, DrPH 3, Prof. Inge Goldstein, DrPH 4, Prof. Ju- Dr. Neil D. Romberg, MD 1, Dr. Ida Hsu, MD 1, Dr. Christina C. dith Jacobson, DrPH3, Prof. William R. Montfort, PhD 5, Prof. Greg Price, MD 1, Dr. Charlotte Cunningham-Rundles, MD, PhD, Freyer, PhD 6 and Prof. Matthew S. Perzanowski, PhD 1, 1Department FAAAAI 2 and Dr. Eric Meffre, PhD 1, 1Yale University School of of Environmental Health Sciences, Mailman School of Public Health, Medicine, New Haven, CT, 2Mt. Sinai Medical Center, New Columbia University, New York,NY, 2Division of Pediatrics, Depart- York, NY ment of Medicine, College of Physician & Surgeons, Columbia Uni- 563 Treatment Of Murine Chronic Granulomatous Disease (CGD) versity, New York, NY, 3Department of Epidemiology, Mailman With The PPAR g Agonist Pioglitazone Enhances Phagocyte Mi- School of Public Health, Columbia University, New York, NY, 4De- tochondrial Reactive Oxygen Species (ROS) Production and partment of Epidemiology, Mailman School of Public Health, Co- Antimicrobial Responses lumbia University, New York, NY, 5Department of Chemistry and Dr. Donna Bratton, MD , Dr. S. Courtney Frasch, PhD, Dr. Ken- Biochemistry, University of Arizona, Tucson, Arizona, 61Depart- neth Malcolm, PhD and Dr. Ruby Fernandez-Boyanapalli, PhD, ment of Environmental Health Sciences, Mailman School of Public National Jewish Health, Denver, CO Health, Columbia University, New York, New York 564 Patient Specific Targeted Gene Therapy In The Treatment Of 570 Divergent Effects Of Endotoxin and Mold Exposure On Asthma X-Linked Hyper-IgM Syndrome Exacerbations In The Childhood Asthma Management Pro- Caroline Y. Kuo, M.D. , Division of Allergy and Immunology, De- gram (CAMP) partment of Pediatrics, David Geffen School of Medicine at UCLA, Dr. Ronina A. Covar, MD 1, Mrs. Anna Forssen, MS 1, Dr. Stanley Los Angeles, CA, Alok Joglekar, PhD, Department of Microbiol- J. Szefler, MD, FAAAAI 2,3, David A. Schwartz, MD 4 and Andrew ogy, Immunology, and Molecular Genetics, University of Califor- H. Liu, MD 1, 1National Jewish Health, Denver, CO, 2University of nia, Los Angeles, Los Angeles, CA and Donald B. Kohn, MD, Colorado Denver School of Medicine, Denver, CO, 3Children’s Department of Pediatrics and Department of Microbiology, Immu- Hospital Colorado, Denver, CO, 4University of Colorado Denver nology, and Molecular GeneticsUniversity of California, Los An- School of Medicine, Aurora, CO geles, Los Angeles, CA SUNDAY 565 Digeorge Syndrome Found By SCID Newborn Screening In California Dr. Kiran P. Patel, MD, MS 1, Dr. Antonia Kwan, PhD, MRCPCH 1, Mica Muskat, MSN1, Dr. Joseph A. Church, MD, FAAAAI 2, Dr. Best of FADDA Morna J. Dorsey, MD MMSc FAAAAI 1 and Dr. Jennifer M. Puck, MD 1, 1Department of Pediatrics, University of California San Fran- 3804 cisco and UCSF Benioff Children’s Hospital, San Francisco, CA, Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM 2Department of Pediatrics, University of Southern California and 571 Inhibition Of Epidermal Tight Junction Function By Histamine Children’s Hospital Los Angeles, Los Angeles, CA Is Mediated By H1 and H4 Receptors Lisa A. Beck, MD, FAAAAI 1, Takeshi Yoshida, PhD 1, Sade Fridy1, I-Hsin Kuo, PhD 1, Donald Y.M. Leung, MD, PhD, FAAAAI 2 and Anna De Benedetto, MD, FAAAAI 1, 1University of Rochester Medical Center, Rochester, NY, 2National Jewish Best of EORD Health, Denver, CO 572 The Natural History and Clinical Predictors Of Egg Allergy In 3803 The First 2 Years Of Life: A Prospective, Population-Based, Co- Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM hort Study 566 Urinary Levels Of Phytoestrogens Are Inversely Associated Ms. Rachel Peters, MPH1,2, Prof. Shyamali Dharmage, MD, With Wheezing, Asthma, and Atopy PhD1,2, Prof. Lyle Gurrin, PhD 2, Dr. Jennifer Koplin, PhD 1, Prof. Juan-Carlos Cardet, MD , Rheumatology, Immunology, and Al- Anne-Louise Ponsonby, PhD 1, Dr. Adrian Lowe, PhD 2, Prof. lergy, Brigham and Women’s Hospital, Boston, MA, Christina Mimi L. K. Tang, MD, PhD, FAAAAI 3, Dr. Dean Tey, MD 1,4, Johns, BA, Brigham and Women’s Hospital, Boston, MA and Jes- Dr. David Hill, MBBD, FRACP 1, Dr. Marnie Robinson, MBBD, sica Rabe Savage, MD , Brigham and Women’s Hospital, Division FRACP 5, Ms. Helen Czech, B.Nurs 1, Ms. Leone Thiele, MNSc 1, of Rheumatology, Immunology and Allergy, Boston, MA Dr. Nicholas Osborne, PhD 6 and Prof. Katrina Jane Allen, MD, 567 Vitamin D Treatment Is Protective Of Inhalant Organic Dust- PhD, FAAAAI 1,4, 1Murdoch Childrens Research Institute, Victoria, Induced Bone Loss Australia, 2University of Melbourne, Victoria, Australia, 3The Uni- Dr. Jill A. Poole, MD, FAAAAI 1, Anand Dusad 1, Dr. Todd Wyatt, versity of Melbourne, Melbourne, Australia, 4Royal Children’s PhD2, Angela Gleason, MA 1, Michael Duryee 1, Elizabeth Klein 1, Hospital, Victoria, Australia, 5Royal Children’s Hospital, Parkville, Christopher Bauer1, Dr. Lynell Klassen, MD 1, Dr. Ted Mikuls, Australia, 6Royal Cornwall Hospital, Truro, United Kingdom MD 1, Dr. William West, MD 1, Dr. Debra Romberger, MD 2 and 573 Mendelian Inheritance Of Elevated Tryptase Associated With Dr. Geoffrey Thiele, PhD 1, 1University of Nebraska Medical Cen- Atopy and Connective Tissue Abnormalities ter, Omaha, NE, 2UNMC, Omaha, NE Dr. Jonathan J. Lyons, MD 1, Dr. Guangping Sun, MD 1, Dr. Kelly 568 Antigenic Determinants On Der p 1 Identified By Mutagenesis D. Stone, MD, PhD, FAAAAI 1, Celeste Nelson, NP 1, Laura Wisch, Analysis Based On The Structure Of Allergen-Antibody Com- MSN1, Michelle O’Brien, RN, BSN 1, Nina Jones, RN, BSN 2, Dr. plexes Andrew W. Lindsley, MD, PhD 3, Dr. Hirsh D. Komarow, MD 1, Dr. Anna Pomes, PhD FAAAAI 1, Ms. Jill Glesner 1, Ms. Lisa D. Yun Bai, MS 1, Linda M. Scott, MS, CRNP 1, Daly Cantave, Vailes 1, Dr. Wladek Minor, PhD 2, Dr. Maksymilian Chruszcz, MSN4, Dr. Irina Maric, MD 5, Dr. J. Pablo Abonia, MD 3, Dr. PhD3 and Dr. Martin D. Chapman, PhD FAAAAI 1, 1Indoor Marc E. Rothenberg, MD, PhD, FAAAAI 3, Dr. Lawrence B.

121 AB332 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Schwartz, MD, PhD, FAAAAI 6, Dr. Todd M. Wilson, DO 1 and Dr. Chronic Rhinosinusitis and Polyps Joshua D. Milner, MD 1, 1Laboratory of Allergic Diseases, NIAID/ NIH, Bethesda, MD, 2Frederick National Laboratory for Clinical 3 3806 Research, Frederick, MD, Cincinnati Children’s Hospital Medical Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM Center, Cincinnati, OH, 4Clinical Center, National Institutes of Health, Bethesda, MD, 5Department of Laboratory Medicine, Na- 581 Activation Of TLR4 Induces VEGF Expression Via Akt Path- tional Institutes of Health, Bethesda, MD, 6Virginia Commonwealth way In Nasal Polyps Mrs. Jung-Sun Cho1, Mr. Ju-Hyung Kang 1, Ms. In-Hye Han 1, University, Richmond, VA 1 2 574 Expression Of TSLP and TSLP-R In Chronic Idiopathic Urti- Mrs. Ji-Young Um , Prof. Il-Ho Park and Prof. Heung-Man Lee2,3, 1Department of Biomedical Sciences, Korea University caria 2 Ms. Patricia M. Sterba, MS 1, Allen Myers, Ph.D 2 and Dr. Sarbjit Graduate School, Seoul, South Korea, Department of Otorhinolar- 1 1 yngology-Head and Neck Surgery, Korea University College of S. Saini, MD, FAAAAI , Johns Hopkins University, Baltimore, 3 MD, 2Division of Allergy & Clinical Immunology, Johns Hopkins Medicine, Seoul, South Korea, Medical Devices Clinical Trial University School of Medicine, Baltimore, MD Center, Guro Hospital, Korea University, Seoul, South Korea 575 Preclinical Study Of Rapidly-Disintegrating Sublingual Tablets 582 Non-Eosinophilic Nasal Polyps In Second-Generation Asian Pa- (RDST): Effect Of Epinephrine (E) Incorporated As Nano- tients In The U.S. With Chronic Rhinosinusitis; Evidence For Genetic Influence On Eosinophilia Crystals 1 2 SUNDAY 1 1 Dr. Mahboobeh Mahdavinia, MD, PhD , Ms. Lydia Suh, BSc , Dr. Keith Simons, PhD , Dr. Ousama Rachid, PhD , Dr. Mutasem 2 2 2 3 3 Mr. James Norton, MS , Mr. Roderick Carter, BSc , Dr. Atsushi Rawas-Qalaji, PhD , Dr. Belacryst Mendez, PhD , Ms. Annette Losada 2 2 1 1 Kato, PhD , Dr. Anju T. Peters, MD, FAAAAI , Dr. Rakesh and Dr. F. Estelle R. Simons, MD, FAAAAI , University of Manitoba, 3 4 2 Chandra, MD , Dr. Bruce K. Tan, MD , Dr. David Conley, Winnipeg, MB, Canada, Nova Southeastern University, F. Lauderdale, 4 4 FL, 3Nova Southeastern University, Ft. Lauderdale, FL MD , Dr. Robert C. Kern, MD , Dr. Leslie C. Grammer, MD, FAAAAI 2 and Dr. Robert P. Schleimer, PhD FAAAAI 5, 1Depart- ment of Medicine, Division of Allergy-Immunology, Northwest- ern University Feinberg School of Medicine, chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Best of HEDQ Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Department of Oto- 3805 laryngology, Northwestern University Feinberg School of Medi- Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM cine, Chicago, IL, 5Division of Allergy-Immunology, 576 A 24-Month Randomized, Controlled Trial Of An Automated Department of Medicine, Northwestern University Feinberg Speech Recognition Program To Improve Adherence In Pediat- School of Medicine, Chicago, IL ric Asthma 583 Regulation Of Expression Of Pendrin Protein In CRS With Na- Bruce G. Bender, PhD FAAAAI 1, Peter Cvietusa 2, Glenn Good- sal Polyps and In Airway Epithelial Cells rich2, C. Ryan Lowe 2, Heather Nuanes 2, Susan Shetterly 2, Cathy Dr. Sudarshan Seshadri, PhD 1, Dr. Xiang Lu, MD, PhD 1, Mr. R. Tacinas 2, Nicole Wagner 2, Frederick S. Wamboldt 1, Stan Xu 2 Matthew Purkey, BS 1, Dr. Tetsuya Homma, MD 1, Mr. Andrew and David Magid 2, 1National Jewish Health, Denver, CO, 2Kaiser Choi1, Mr. Roderick Carter, BSc 1, Mr. James Norton, MS 1, Ms. Ly- Permanente Colorado, Denver, CO dia Suh, BSc1, Dr. Atsushi Kato, PhD 1, Prof. Pedro C. Avila, MD, 577 Asthma Carepartners: A Home-Based Asthma Intervention FAAAAI 1, Dr. Anju T. Peters, MD, FAAAAI 1, Dr. David Conley, Embedded Within Medicaid Managed Care MD 2, Dr. Rakesh Chandra, MD 3, Dr. Bruce K. Tan, MD 2, Dr. Leslie Ms. Julie Kuhn, MSW 1, Ms. Helen Margellos-Anast, MPH 1, Ms. Tala C. Grammer, MD, FAAAAI 1, Dr. Robert C. Kern, MD 2 and Dr. Alhajj Schwindt, MPH 1, Ms. Lourdes Reyes 2, Ms. Barbara Hay,M.A. 2, Robert P. Schleimer, PhD FAAAAI 4, 1Department of Medicine, Di- Ms. Sheena Freeman, B.A. 1 and Ms. Gloria Seals 1, 1Sinai Urban Health vision of Allergy-Immunology, Northwestern University Feinberg Institute, Chicago, IL, 2Family Health Network, Chicago, IL School of Medicine, Chicago, IL, 2Department of Otolaryngology, 578 The Osia Platform: An Extensible Tool For Improving Individ- Northwestern University Feinberg School of Medicine, Chicago, ual Allergy and Asthma Control and Understanding Environ- IL, 3Northwestern University, Chicago, IL, 4Division of Allergy- mental Drivers Immunology, Department of Medicine, Northwestern University Dr. Richard W Lucas, PhD 1, Mr. Josh Dees 2, Mr. Rob Reynolds 2, Feinberg School of Medicine, Chicago, IL Mr. Bryn Rhodes 3 and Dr. Richard W Hendershot, MD 4, 1Swedish 584 Sex-Specific Differences In Disease Severity In Patients With University of Agricultural Sciences, Ume a, Sweden, 2OSIA Medi- Chronic Rhinosinusitis With Nasal Polyps cal, Sandy, UT, 3Database Consulting Group, Orem, UT, 4Inter- Dr. Kathryn E. Hulse, PhD 1, Dr. Whitney Wyatt Stevens, MD, mountain Health Care, Salt Lake City, UT PhD2, Dr. Bruce K. Tan, MD 3, Mr. James Norton, MS 2, Ms. Ly- 579 Allergy Immunotherapy Significantly Reduces Outpatient Ser- dia Suh, BSc2, Dr. Robert C. Kern, MD 3, Dr. David Conley, vices Use For Allergy and Respiratory Conditions In Patients MD 3, Dr. Rakesh Chandra, MD 1, Dr. Anju T. Peters, MD, With Newly-Diagnosed Allergic Rhinitis FAAAAI 2, Dr. Leslie C. Grammer, MD, FAAAAI 2, Ms. Kathleen Dr.Cheryl S. Hankin, PhD 1, Dr. Linda Cox, MD, FAAAAI 2, Dr. Amy E. Harris, BSc 2, Mr. Roderick Carter, BSc 2, Dr. Atsushi Kato, Bronstone, PhD 1 and Ms. Zhaohui Wang, M.S. 1, 1BioMedEcon, LLC, PhD2, Dr. Margrit Urbanek, PhD 4 and Dr. Robert P. Schleimer, Moss Beach, CA, 2Allergy & Asthma Center, Fort Lauderdale, FL PhD FAAAAI 5, 1Northwestern University, Chicago, IL, 2Depart- 580 Real-Time Asthma Outreach Reduces Excessive Short-Acting ment of Medicine, Division of Allergy-Immunology, Northwest- Beta-Agonist (SABA) Canister-Dispensing: A Randomized ern University Feinberg School of Medicine, Chicago, IL, Study 3Department of Otolaryngology, Northwestern University Fein- Dr. Robert S. Zeiger, MD, PhD, FAAAAI 1, Dr. Michael Schatz, berg School of Medicine, Chicago, IL, 43Division of Endocrinol- MD, MS, FAAAAI 1, Qiaowu Li, M.S. 2, Dr. James Zazzali, PhD 3 ogy, Metabolism and Molecular Medicine, Northwestern and Wansu Chen, M.S. 2, 1Kaiser Permanente Southern California, University Feinberg School of Medicine, 5Division of Allergy- San Diego, CA, 2Kaiser Permanente Southern California, Pasadena, Immunology, Department of Medicine, Northwestern University CA, 3Genentech, Inc., South San Francisco, CA Feinberg School of Medicine, Chicago, IL

122 J ALLERGY CLIN IMMUNOL Abstracts AB333 VOLUME 133, NUMBER 2

585 The Role Of Innate Cytokine In Non-Asthmatic, Non-Eosino- 1Johns Hopkins University School of Medicine, Baltimore, MD, philic Nasal Polyps: IL-25, IL-33 and TSLP 2Johns Hopkins University School of Medicine, 3Pediatrics, Johns Dr. Dong-Kyu Kim 1, Dr. Hyun-Woo Shin 2, Dr. Jong-Wan Park 2, Hopkins University School of Medicine, Baltimore, MD, 4Gei- Dr. Min-Suk Yang 3 and Dr. Dae Woo Kim 3, 1Chuncheon Sacred singer Community Medical Center., Scranton, PA, 5Johns Hopkins Heart Hospital, Hallym University College of Medicine, South Ko- University Medical Center, Baltimore, MD rea, 2Seoul National University College of Medicine, Pharmacology and Biomedical Science, Ischemic/Hypoxic Disease Institute, South Korea, 3Seoul National University Hospital and Boramae Medical Center, South Korea Epidemiology: Asthma Control

4201 The Redwan Moqbel Memorial MAAI Featured Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 592 Asthma In The Elderly: The Role Of Vitamin D Poster Session Dr. Michele Columbo, MD, FAAAAI , Asthma, Allergy and Im- munology Specialists, Bryn Mawr, PA, Dr. Reynold A. Panettieri 3807 Jr., MD, University of Pennsylvania, Philadelphia, PA and Dr. Al- Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM bert S. Rohr, MD, FAAAAI, Rohr and Columbo Asthma, Allergy 586 IL33 and Type 2 Innate Lymphoid Cells (ILC2) But Not Th2 and Immunology Specialists, Bryn Mawr, PA Cells Are Essential For Persistence Of Chronic Experimental 593 A Preliminary Randomized Controlled Trial:Educational Inter- Asthma vention For Treatment Of Hispanic and African American Dr. Christina Christianson, PhD , Ms. Chaoyu Irvin, MS, Magda- Adults With Asthma: Allergen Triggers, Peak Flow, and Spi- lena Gorska, MD, PhD and Rafeul Alam, MD, PhD, FAAAAI, Na- rometry tional Jewish Health, Denver, CO Reenal Patel, MD , UMDNJ, Newark, NJ, Josha Fogel, PhD, Nas- 587 PGE2 Deficiency Causes a Phenotype Of Aspirin Sensitive sau University Medical Center, East Meadow, NY and Marianne Asthma That Depends On Platelets and Cysteinyl Leukotrienes Frieri, MD, PhD, FAAAAI, State University of NY @ Stony brook, Dr.TaoLiu, PhD 1,2 , Dr. Joshua A. Boyce, MD, FAAAAI 1,2 , Dr. Tanya Stony Brook, NY M. Laidlaw, MD, FAAAAI 1,2 and Dr. Howard Katz, PhD 1,2 , 1Brigham 594 Assessment Of Asthma Education and Teaching Practices

and Women’s Hospital, Division of Rheumatology, Immunology and Among Allergists SUNDAY Allergy, Boston, MA, 2Harvard Medical School, Boston, MA Natalia Vernon, M.D. , Penn State Hershey Medical Center, Her- 588 CCR8 Is a Receptor For CCL18 On Human Th2 Cells shey, PA and Dr. Timothy Craig, D.O., Penn State University, Her- Dr. Morris Ling, MD 1, Dr. Sabina Islam, MD 1,2, Dr. John Leung, shey, PA MD 3, Wayne G. Shreffler, MD, PhD, FAAAAI 1,2 and Dr. Andrew 595 Comparison Of Asthma-Related ED Visits In Public Versus Pri- D. Luster, MD, PhD 4,5, 1Massachusetts General Hospital, Boston, vate Hospitals In The Bronx MA, 2Harvard Medical School, Boston, MA, 3Tufts Medical Cen- Dr. Mili Shum, MD , Weill Cornell Medical College, New York, ter, Boston, MA, 4Massachusetts General Hospital, Charlestown, NY; Montefiore Medical Center, Bronx, NY, Dr. David L. Rose- MA, 5Harvard Medical School, Charlestown, MA nstreich, MD, FAAAAI, Albert Einstein/Montefiore Medical Cen- 589 Increased Frequency Of Dual Positive Th2/Th17 Cells In Bron- ter, Bronx, NY and Dr. Sunit Jariwala, MD, Albert Einstein/ choalveolar Lavage Characterizes a Population Of Severe Asth- Montefiore Medical Center, New York, NY matic Patients 596 Comparison Of Pre- and Post-Pubertal Gender Differences In Rafeul Alam, MD, PhD, FAAAAI , Ms. Chaoyu Irvin, MS, Dr. Markers Of Angiogenesis and Asthma Outcomes 1 2 James Good, MD, Dr. Donald Rollins, MD, Dr. Christina Christian- Dr. Amy Thomas, MD , Mark DeVries , Mr. Christopher J. Tisler, 2 3 son, PhD, Ms. Iram Zafar, MS, Magdalena Gorska, MD, PhD and MT , Ms. Victoria Rajamanickam , Dr. James E. Gern, MD, 2 2 Dr. Richard J. Martin, MD, National Jewish Health, Denver, CO FAAAAI , Dr. Robert F. Lemanske Jr., MD, FAAAAI and Dr. 4 1 590 Cmrf-35-Like Molecule 1 (CLM-1) Is Required For IL-4-In- Daniel J. Jackson, MD , University of Wisconsin Hospitals and 2 duced Cellular Responses and Development Of Allergic Airway Clinics, Madison, WI, University of Wisconsin School of Medi- 3 Inflammation cine and Public Health, Madison, WI, University of Wisconsin 4 Mr. Itay Moshkovits 1, Mrs. Danielle Karo-Atar 1, Mrs. Dana Shik 1, Hospitals and Clinics, Pediatrics, University of Wisconsin School Dr. Alon Hershko, MD, PhD 2 and Dr. Ariel Munitz, PhD 1, 1Depart- of Medicine and Public Health, Madison, WI ment of Clinical Microbiology and Immunology, The Sackler 597 Asthma Exacerbation In U.S. Adults: Who Are The Frequent School of Medicine, Tel-Aviv University, Tel Aviv, Israel, 2Labora- Utilizers Of The Emergency Department? 1,2 1 tory of Allergy and Clinical Immunology, Department of Medici- Dr. Kohei Hasegawa, MD, MPH , Ashley Sullivan, MPH, MS , 3 4 ne,The Herbert Center of Mast Cell Disorders, Meir Medical Stuart Turner, BPharm, MPH , Susan Massaro, PharmD, MPH and 1,2 1 Center, Kfar Saba, Israel Dr. Carlos Camargo Jr., MD, DrPH , Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Novartis Pharmaceuticals Corpora- tion, East Hanover, NJ, 4Novartis Pharmaceuticals 598 The Relationship Of The Serum Vitamin D Levels With Asth- Allied Health Featured Poster matic Severity Responses In Asthmatic Children Dr. Julio Orellana 1, Dr. Telma Varela 2, Dr. Ana Romero Boni 1, Dr. 3811 Ofelia Mi no~ 1, Dr. Estela Pautasso 1, Dr. Susana Rivolta 1, Dr. Ram on Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM Pogonza3 and Dr. Juan Carlos Muino, MD, PhD, FAAAAI 4, 1Nuevo 591 Quality Of Life Improves In Children Undergoing Peanut Im- Hospital de Ni nos~ de la Santisima Trinidad Cordoba Argentina, munotherapy Cordoba, Argentina, 2Nuevo Hospital de Ni nos~ de la Santisima Tri- Ms. Shannon Seopaul, BS 1, Dr. Satya Narisety, MD 2, Corinne nidad Cordoba Argentina, Cordoba, Argentina, 3Nuevo Hospital de Keet, MD, MS 3, Ms. Kim E. Mudd, RN MSN CCRP 1, Ms. Sarah Ni nos~ de la Santisima Trinidad Cordoba Argentina - CIU, Cordoba, D. Knorr, RN MPH CCRP 4 and Robert A. Wood, MD, FAAAAI 5, Argentina, 4FAC CS MED UNC, Cordoba, Argentina

123 AB334 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

599 Newly Diagnosed Asthma In The Elderly: Is It Really Differ- Montefiore Medical Center, Bronx, NY, 5Albert Einstein College ent? of Medicine, Bronx, NY Prof. Bilun Gemicioglu, MD, PhD , Istanbul Univ. Cerrahpasa Faculty 606 Ashmi Suppresses Neutrophil Pulmonary Inflammation In a of Medicine, Istanbul, Turkey, Prof. Oznur Abadoglu, MD, Cumhur- Ragweed Allergic Asthma Model That Is Associated With Mod- iyet Univ. Faculty of Medicine, Sivas, Turkey, Dr. Levent Akyildiz, ulation Of Innate and Adaptive Immune Responses MD, Mardin Medical Park Hospital, Mardin, Turkey, Prof. Hasan Dr. Kamal D. Srivastava, PhD 1, Dr. David Dunkin, MD 2, Dr. Nan Bayram, MD, PhD, University of Gaziantep, Gaziantep, Turkey, Yang, PhD, MS 1, Dr. Changda Liu, PhD 1, Dr. Rachel L. Miller, MD, Prof. Aykut Cilli, MD, Akdeniz Univ. Faculty of Medicine, Antalya, FAAAAI 3 and Dr. Xiu-Min Li, MD 1, 1Pediatrics, Icahn School of Med- Turkey, Prof. Arif Cimrin, MD, Dokuz Eylul Univ. Faculty of Medi- icine at Mount Sinai, New York, NY, 2Icahn School of Medicine at cine, Izmir, Turkey, Prof. Hakan Gunen, MD, Sureyyapasa Pulmonary Mount Sinai, New York, NY, 3Division of Pulmonary, Allergy and Crit- Diseases Hospital and Research Center, Istanbul, Turkey, Prof. Zeynep ical Care Medicine, Columbia University, New York, NY Misirligil, MD, Ankara Univ. Faculty of Medicine, Ankara, Turkey, 607 Longitudinal Characteristics Of Viral and Non-Viral Exacerba- Prof. Tevfik Ozlu, MD, Karadeniz Teknik Univ. Faculty of Medicine, tions Of Childhood Asthma Trabzon, Turkey, Prof. Mecit Suerdem, MD, Selcuk Univ. Faculty of Dr. Amaziah Coleman, MD 1, Dr. Daniel J. Jackson, MD 2, Dr. Ro- Medicine, Konya, Turkey and Prof. Esra Uzaslan, MD, Bursa Univ. nald E. Gangnon, PhD 1, Mr. Michael D. Evans, MS 1, Dr. Robert F. Faculty of Medicine, Bursa, Turkey Lemanske Jr., MD, FAAAAI 1 and Dr. James E. Gern, MD, 600 Risk Factors For Acute Asthma In The City Of FAAAAI 1, 1University of Wisconsin School of Medicine and Public Esmeraldas, Ecuador Health, Madison, WI, 2Pediatrics, University of Wisconsin School Dr. Cristina Ardura-Garcia 1, Gisela Oviedo 2, Maritza Vaca 2, Car- of Medicine and Public Health, Madison, WI los Sandoval 2, Stefanie Menzies 2, Lisa J. Workman, BA 3, Prof. Matthew S. Perzanowski, PhD 4, Maria Jose Rosa 5, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 3 and Dr. Phil J. Cooper 2,6, 1Uni- versity of Liverpool, Wellcome Trust PhD Fellow, Liverpool, United Kingdom, 2Laboratorio de FEPIS, Quinind e, Esmeraldas Biomarkers and Asthma Control II Province, Ecuador, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 4Depart- 4202 ment of Environmental Health Sciences, Mailman School of Public Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Health, Columbia University, New York, NY, 5Columbia Univer- 608 Bronchial Epithelial Cell Gene Expression In Relation To Ex- sity, New York, NY, 6St. George’s University, London, United haled Nitric Oxide Identifies New Molecular Asthma Pheno- Kingdom types 601 Serum Vitamin D Levels and Clinical Features Of The Disease Dr. Brian D. Modena, MD 1, Dr. John Tedrow, MD 1, Dr. Jadranka In Children With Asthma Aged 5 –To 18 Years Old Milosevic, PhD1, Dr. Naftali Kaminski, MD 2 and Sally E. Wenzel, Dr. Zeynep Tamay, MD , Associate Professor of Pediatrics, Istan- MD, FAAAAI 1, 1University of Pittsburgh Medical Center NW, bul University, Istanbul School of Medicine, Department of Pediat- Pittsburgh, PA, 2Yale-New Haven Hospital, New Haven, CT

MONDAY rics, Division of Pediatric Allergy, Istanbul, Turkey, Dr. Nurhan 609 How Common Is The Phenotype Reflected By ‘‘The Atopic Ozcan, Ege Medical Faculty, Department of Pediatrics, Prof. Fir- March’’? Results At Two Years Of Age In a General Risk devs Bas, Istanbul University, Istanbul School of Medicine, Depart- Multi-Racial Birth Cohort ment of Pediatrics; Division of Pediatric Endocrinology, Prof. Umit Dr. Christine Cole Johnson, PhD MPH FAAAAI 1, Ms. Suzanne Turkoglu, Istanbul University, Istanbul School of Medicine, Depart- Havstad, M.A. 1, Dr. Dennis Ownby, M.D. FAAAAI 2, Dr. Christine ment of Pediatrics, Division of Biochemistry and Prof. Nermin Gu- L.M. Joseph, PhD1, Dr. Haejin Kim, MD 3, Kimberley J. Woodcroft, ler, MD, Istanbul University, Istanbul School of Medicine, PhD1, Dr. Edward M. Zoratti, MD, FAAAAI 4 and Ganesa We- Department of Pediatrics, Division of Pediatric Allergy, Turkey gienka, PhD1, 1Department of Public Health Sciences, Henry 602 Effectiveness Of Specific Immunotherapy Against Alternaria Ford Hospital, Detroit, MI, 2Department of Pediatrics Georgia Re- Alternata In Patients With Asthma and Or Allergic Rhinitis gents University, Augusta, GA, 3Division of Allergy and Clinical Dr. Silvia Mart ınez Blanco, MD 1, Dr. Ana Ant on-Laiseca, MD 1, Immunology, Henry Ford Hospital, Detroit, MI, 4Henry Ford Dr. R. Mielgo Ballesteros, MD 1, Dr. Consuelo Fern andez Health System, Detroit, MI Rodrıguez, MD, PhD1, Dr. Ruth Barranco Jim enez, MD 1 and Dr. 610 Is Asthma Predictive Index Feasible For A Retrospective R. Vives Conesa, MD 2, 1Hospital Universitario 12 de Octubre, Study? Spain, 2Hospital Universitario 12 de Octubre, Madrid, Spain Dr. Chung I. Wi, MD 1, Dr. Miguel A. Park, MD 2 and Dr. Young J. 603 Vitamin D Levels As Related To Severity and Ethnicity In Asth- Juhn, MD, MPH1, 1Dept of Pediatric and Adolescent Medicine, matics Mayo Clinic, Rochester, MN, 2Department of Internal Medicine: Dr. Patricia H. Stewart, MD 1, Dr. Thomas Pressley, PharmD 1, Dr. Division of Allergic Diseases, Mayo Clinic, Rochester, MN Deborah Minor, PharmD 1 and Prof. Gailen D. Marshall Jr., MD, 611 Comparison Of Rates Of Prescribing Oral Corticosteroids For PhD, FAAAAI 2, 1University of Mississippi Medical Center, 2Uni- Asthma Exacerbations Between Step-Down Therapy Ap- versity of Mississippi Medical Center, Jackson, MS proaches Among Initiators Of Inhaled Corticosteroids and 604 Real Life Study Of Safety and Efficacy Of Subcutaneous Immu- Long-Acting Beta-Agonist Combination Therapy notherapy With Cat and Dog Extracts Ayad K. Ali, PhD 1,2, Almut Winterstein, PhD 2, Leslie Hendeles, Ms. Silvia Uriarte and Prof. Joaquin Sastre, MD, PhD, FAAAAI, PharmD2, Xiaomin Lu, PhD 3, Richard Segal, PhD 2 and Abraham Fundacion Jim enez Dıaz, Madrid, Spain Hartzema, PhD2, 1Eli Lilly and Company, Indianapolis, IN, 2Col- 605 Improvement In Quality Of Life In Parents Of Asthmatic Chil- lege of Pharmacy, University of Florida, Gainesville, FL, 3College dren Aged < 4 Years Receiving Subcutaneous Allergy Immuno- of Public Health and Health Professions, College of Medicine, Uni- therapy versity of Florida, Gainesville, FL Yurydia Jorge 1, Yikania Pichardo 1, Paola Polanco, MD 2, Xin 612 The Good, The Bad and The Ugly Of The Naepp EPR3 Guide- Zheng, PhD3, Jose Adames, BS 3, Dr. Andrew A. Wiznia, MD 3, lines Dr. David L. Rosenstreich, MD, FAAAAI 4 and Dr. Gabriele De Dr. Priyanka Lall, MD , Emory University, Atlanta, Dr. Karen A. Vos, MD 5, 1Jacobi Medical Center, New York, NY, 2Jacobi Medical DeMuth, MD, FAAAAI, Emory University, Atlanta, GA and Dr. Center, 3Albert Einstein College of Medicine, 4Albert Einstein/ Morton Galina, Emory University

124 J ALLERGY CLIN IMMUNOL Abstracts AB335 VOLUME 133, NUMBER 2

613 Fibrin Complexes From The Sputum Of Human Asthmatics Dr. Isaac Reuven Melamed, MD 1, Dr. Richard L. Wasserman, MD, Contain Viable Fungi PhD, FAAAAI 2, Dr. Mark Stein, MD, FAAAAI 3, Dr. Arye Rubinstein, Dr. Rani Maskatia, MD 1, Cameron Landers, B.S 1, Dr. Evan Li, MD, FAAAAI 4, Dr. Jennifer M. Puck, MD 5, Sudhir Gupta, MD, PhD, M.D.1, Dr. Roger Rossen, M.D. 1,2, Dr. Frank M. Orson, MD, FAAAAI 6, Werner Engl 7, Dr. Heinz Leibl, PhD 7, Dr. Leman Yel, MD, FAAAAI 1,2 and Dr. David B. Corry, MD 1, 1Baylor College of Med- FAAAAI 8 and Dr. Richard I. Schiff, MD, PhD 8, 1IMMUNOe Health icine, Houston, TX, 2Veterans Affairs Medical Center, Houston, TX Centers, Centennial, CO, 2DallasAllergyImmunology, Dallas, TX, 614 Proteomic Identification Of S100A8 As a Potential Effector Pro- 3Allergy Associates of the Palm Beaches, North Palm Beach, FL, 4Al- tein Of Acupuncture In Asthma Treatment bert Einstein College of Medicine, Bronx, NY, 5Department of Pediat- Yu-Dong Xu 1,2, Yu Wang 1, Ying Wei 1, Lei-Miao Yin 1, Jun Ran 1 rics, University of California San Francisco and UCSF Benioff and Yong-Qing Yang 1,2, 1Molecular Biology Laboratory, Shanghai Children’s Hospital, San Francisco, CA, 6University of California, Ir- Research Institute of Acupuncture and Meridian, Shanghai Univer- vine, Irvine, CA, 7Baxter BioScience, Vienna, Austria, 8Baxter BioSci- sity of Traditional Chinese Medicine, Shanghai, China, 2Yue Yang ence, Westlake Village, CA Hospital, Shanghai University of Traditional Chinese Medicine, 622 Health-Related Quality Of Life Of Japanese Patients With Pri- Shanghai, China mary Immunodeficiency Diseases Receiving IgPro20, a 20% 615 Are Asthma Specialists and Non-Specialists Familiar With In- Liquid Subcutaneous Immunoglobulin (HizentraÒ) haled Corticosteroid (ICS) Dosing Recommendations and Side Prof. Hirokazu Kanegane, MD, PhD 1, Prof. Kohsuke Imai, MD, Effects In Children With Asthma? PhD2, Prof. Masafumi , MD, PhD 3, Prof. Hidetoshi Takada, Dr. Jonathan Drori , West Penn Allegheny Health System, Pitts- MD, PhD4, Prof. Tadashi Ariga, MD, PhD 3, Prof. Ataru Igarashi, burgh, PA PhD5, Prof. Kiichiro Tsutani, MD, PhD 5, Dr. Martin Bexon, 616 Medication Remaining In Discarded Metered Dose Inhalers Of MD 6, Dr. Mikhail Rojavin, PhD 7, Ms. Midori Kobayashi, BSPharm, Asthmatic Children MBA 8, Dr. John-Philip Lawo, PhD 9, Mr. Art Zbrozek, RPh, MSc, Dr. Wantida Dampanrat, MD , Prince Of Songkla University, Ha- MBA 10 , Prof. Shigeaki Nonoyama, MD, PhD 11 , Prof. Toshiro tyai, Thailand, Dr. Pasuree Sangsupawanich, MD, Prince Songkhla- Hara, MD, PhD4 and Prof. Toshio Miyawaki, MD, PhD 1, 1Depart- nagarind hospital, Hadyai, Thailand and Dr. Araya Yuenyongviwat, ment of Pediatrics, Graduate School of Medicine and Pharmaceuti- MD, Prince of Songkla University, Songkhla, Thailand cal Sciences, University of Toyama, Toyama, Japan, 2Department 617 Defining Severe Asthma In Childhood: A Descriptive Multicen- of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo ter Study In Turkey Medical and Dental University, Tokyo, Japan, 3Department of Pedi- Bulent Enis Sekerel 1, Dr. Ozge Soyer 2, Fatih Celmeli 3, Yakup atrics, Hokkaido University Graduate School of Medicine, Sapporo, Canitez3, Ozlem Keskin 3, Demet Can 3, Ferhat Catal 3, Mehtap Japan, 4Department of Pediatrics, Graduate School of Medical Sci- Kilic3, Burcin Nalbantoglu 3, Nail Yologlu 3, Suleyman T. Yavuz 3, ences, Kyushu University, Fukuoka, Japan, 5Department of Drug Belgin Guc3, Fadil Ozturk 3, Gulbin Karakoc 3, Suna Asilsoy 3, Meh- Policy and Management, Graduate School of Pharmaceutical Sci- met Kilic3, Cem Razi 3, Dost Zeyrek 3, Semanur Kuyucu 3, Hasan ences, The University of Tokyo, Tokyo, Japan, 6Clinical Research Yuksel 3, Omer Cevit 3, Aysen Bingol 3, Mehtap G. Yazicioglu 3 and and Development, CSL Behring AG, Berne, Switzerland, 7Clinical Ayse Yenigun 3, 1Hacettepe University, Pediatric Allergy Unit, An- Research and Development, CSL Behring LLC, King of Prussia, kara, Turkey, 2Hacettepe University School of Medicine, Ankara, PA, 8Research and Development, CSL Behring K.K., Tokyo, Japan, Turkey, 3TURPEDAS, Turkey 9CSL Behring GmbH, Marburg, Germany, 10 CSL Behring LLC, 618 The Pediatric Diagnostic Conundrum Of Chronic Respiratory King of Prussia, PA, 11 Department of Pediatrics, National Defense Symptoms Medical College, Tokorozawa, Japan Zainab Kagen, MD , University of Tennesee College of Medicine- 623 Efficacy and Tolerability Of Privigen Ò In Clinical Practice Chattanooga, TN, Joel Ledbetter, MD, University of Tennessee Col- Dr. Morna J. Dorsey, MD MMSc FAAAAI 1, Viet Ho 2, Dr. Moh- lege of Medicine-Chattanooga, TN, Jennifer Hamm, MD, University sen I. Mabudian, MD 3, Pere Soler-Palac ın 4, Nerea Dom ınguez-Pi- of Tennesee College of Medicine-Chattanooga and Esther Wilson, nilla5, Dr. Robert W. Hellmers, MD, FAAAAI 6, Dr. Radha MD, University of Tennessee College of Medicine-Chattanooga Gandhi Rishi, MD, FAAAAI 6, Rahul Rishi 7, Dr. Duane W. Wong, MD 6, Dr. Mikhail Rojavin, PhD 8, Dr. Alphonse Hubsch 9 and Dr. Melvin Berger, MD, PhD, FAAAAI 8, 1Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 2Mof- IVIG and Other Therapeutics fitt Cancer Hospital, FL, 3Beaver Medical Group, Inc., Department of Allergy and Clinical Immunology, Redlands, CA, 44Pediatric In- MONDAY 4203 fectious Diseases and Immunodeficiencies Unit, Hospital Universi- Monday, March 3rd, 2014, 9:45 AM - 10:45 AM tari Vall d’Hebron, Barcelona, Spain, 55Department of Pediatrics, 619 Quantification Of The Wear-Off Effect Towards The End Of Hospital 12 de Octubre, Madrid, Spain, 6Arizona Allergy Associ- The Intravenous Immunoglobulin Infusion Interval: Pooled ates, Chandler, AZ, 7Arizona Allergy Associates, Phoenix, AZ, Data Analysis 8Clinical Research and Development, CSL Behring LLC, King of Mr. John-Philip Lawo , CSL Behring GmbH, Marburg, Germany, Prussia, PA, 9CSL Behring AG, Berne, Switzerland Dr. Alphonse Hubsch, CSL Behring AG, Berne, Switzerland and 624 Safety and Tolerability Of An Intravenously Administered Al- Dr. Mikhail Rojavin, PhD, Clinical Research and Development, pha1-Proteinase Inhibitor (A1PI) At An Increased Infusion CSL Behring LLC, King of Prussia, PA Rate: A Randomized, Rate Control, Placebo-Masked, Cross- 620 Safety and Efficacy Of Biweekly Hizentra Ò Administration In over Study In Healthy Adults Patients With Primary Immunodeficiency Diseases: A Retro- Adam Haeberle1, Leock Ngo 1, Neil Inhaber 1, David Gelmont 1 and spective Single-Center Study Dr. Leman Yel, MD, FAAAAI 2, 1Baxter BioScience, 2Baxter Bio- Clare Malcolmson and Dr. Alison Jones, Great Ormond Street Science, Westlake Village, CA Hospital, London, United Kingdom 625 Pharmacokinetic Modeling Predicts Different IgG Exposures 621 Long-Term Tolerability and Safety Of Facilitated-Subcutaneous Using Different IVIG-Scig Dose Conversion Factors In Patients Infusion Of Human Immune Globulin G (IgG), 10%, and Re- With Primary Immune Deficiency combinant Human Hyaluronidase (rHuPH20) (IGHy): A Phase Dr. Jagdev S. Sidhu, PhD 1, Dr. Mikhail Rojavin, PhD 2, Dr. Melvin 3 Extension Study In Patients With Primary Immunodefi- Berger, MD, PhD, FAAAAI 2, Dr. Martin Bexton 3 and Dr. Jonathan ciencies (PIs) M. Edelman, MD 2, 1Clinical Pharmacology & Early Development,

125 AB336 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

CSL Ltd, Parkville, Australia, 2Clinical Research and Development, 634 Retrospective Analysis Of The Clinical Utility Of Biweekly Dos- CSL Behring LLC, King of Prussia, PA, 3CSL Behring AG, Berne, ing With High-Concentration Subcutaneous Immunoglobulin Switzerland In 10 Patients With Primary Immunodeficiency 626 Flexible Dosing For Hizentra Ò: Pharmacokinetic Simulations Dr. Richard L. Wasserman, MD, PhD, FAAAAI 1, Dr. Shahnaz Of Various Subcutaneous Dosing Regimens and Compliance Fatteh2, Dr. Javaid M. Khan, DO 2 and Dr. Elie Haddad, MD 3, In Patients With Primary Immunodeficiency 1Medical City Children’s Hospital, Dallas, TX, 2Larkin Community Dr. Mikhail Rojavin, PhD 1, Dr. Jagdev S. Sidhu, PhD 2, Dr. Martin Hospital, South Miami, FL, 3CHU Sainte-Justine, Montreal, QC, Bexon, MD 3 and Dr. Jonathan M. Edelman, MD 1, 1Clinical Re- Canada search and Development, CSL Behring LLC, King of Prussia, PA, 2Clinical Pharmacology & Early Development, CSL Ltd, Park- ville, Australia, 3Clinical Research and Development, CSL Behring AG, Berne, Switzerland 627 Effect Of Synthetic Steroids and Hydroxychloroquine On B- Autoinflammatory Disorders Cell IgE Production Dr. Ahila Subramanian, MD, MPH , Yingchun Han and Dr. Fred 4204 H. Hsieh, MD, Cleveland Clinic Foundation, Cleveland, OH Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Ò 628 Safety, Tolerability, and Efficacy Of Hizentra In Japanese Pa- 635 Concomitant FMF and TRAPS Mutation In a Periodic Fever tients With Primary Immunodeficiency Over 48 Weeks Patient Prof. Kohsuke Imai, MD, PhD 1, Prof. Hirokazu Kanegane, MD, Dr. Adrianne C. Netterville, MD 1, Dr. Victoria Dimitriades, MD 1 PhD 2, Prof. Masafumi Yamada, MD, PhD 3, Prof. Hidetoshi Takada, and Dr. Paul D. Niolet, MD 2, 1Louisiana State University Depart- MD, PhD 4, Prof. Tadashi Ariga, MD, PhD 3, Ms. Midori Kobayashi, ment of Pediatrics, New Orleans, LA, 2Allergy Asthma and Immu- BSPharm, MBA 5, Dr. Mikhail Rojavin, PhD 6, Dr. Martin Bexon, nology, Ocean Springs, MS MD 7, Prof. Shigeaki Nonoyama, MD, PhD 8, Prof. Toshiro Hara, 636 Association Of Interleukin-23 Receptor Single Nucleotide Poly- MD, PhD 4 and Prof. Toshio Miyawaki, MD, PhD 2, 1Department of morphisms With Ulcerative Colitis Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Med- Dr. Mona Hedayat, MD , Boston Children’s Hospital, Boston, MA, ical and Dental University, Tokyo, Japan, 2Department of Pediatrics, Dr. Nasser Ebrahimi Daryani, Department of Gastroenterology and Graduate School of Medicine and Pharmaceutical Sciences, University Hepatology, Tehran University of Medical Sciences, Dr. Farnaz of Toyama, Toyama, Japan, 3Department of Pediatrics, Hokkaido Uni- Najmi Varzaneh, Molecular Immunology Research Center, Depart- versity Graduate School of Medicine, Sapporo, Japan, 4Department of ment of Immunology, Tehran University of Medical Sciences and Pediatrics, Graduate School of Medical Sciences, Kyushu University, Dr. Nima Rezaei, MD, PhD, Research Center for Immunodefi- Fukuoka, Japan, 5Research and Development, CSL Behring K.K., To- ciencies, Children’s Medical Center, Tehran University of Medical kyo, Japan, 6Clinical Research and Development, CSL Behring LLC, Sciences, Tehran, Tehran, Iran King of Prussia, PA, 7Clinical Research and Development, CSL Behr- 637 A Novel Immunoablative Regimen Utilized In The Successful ing AG, Berne, Switzerland, 8Department of Pediatrics, National De- Remission Of Pulmonary Hemorrhage In An Adolescent Fe-

MONDAY fense Medical College, Tokorozawa, Japan male With Systemic 629 In Vitro Effect Of Intravenous Immunoglobulin (IVIG) On Nat- Ms. Vivian E. Cino, MSN ARNP-BC PNP 1, Alexander Constan- ural Antibody Producing Human B1 Cells tinescu, MD 2, Kristina Deeter, MD 2, Faina Shenderov, PharmD 2, Kevin A. Cook, MD 1, Sudhanshu Agrawal, MS 1 and Sudhir Gupta, Joan Spiro, PharmD2 and Dr. Gary I. Kleiner, MD, PhD, FAAAAI 2, MD, PhD, FAAAAI 2, 1University of California, Irvine, 2University 1Joe Dimaggio Children’s Hospital, Hollywood, FL, 2Joe Dimaggio of California, Irvine, Irvine, CA Children’s Hospital 630 Effect Of A Novel, Oral Histamine H4R Antagonist On Hista- 638 Haptoglobin Deficiency and Autoimmune Manifestations; A mine-Induced Pruritus In Healthy Subjects Case Series Dr. Alexa P. Kollmeier, MD 1, Paul Dunford, MSc 1, Xie Xu, PhD 1, Dr. Anna Kochin, MD 1, Dr. Jenny Shliozberg, MD, FAAAAI 1 and Andrew Greenspan, MD 1, Yichuan Xia, PhD 2, Bei Zhou, PhD 2, Dr. Arye Rubinstein, MD, FAAAAI 2, 1Montefiore Medical Center, Klaus Francke, MD, PhD3 and Dr. Robin L. Thurmond, PhD 1, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY 1Janssen Research & Development, LLC, La Jolla, CA, 2Janssen 639 Immunogenicity Analysis Of Two Anti-TNF (Infliximab vs Eta- Research & Development, LLC, Spring House, PA, 3Parexel Inter- nercept) Therapies In Rheumatologic Patients national, London, United Kingdom Dr. Yvelise Barrios, MD, PhD 1, Dr. Victor Matheu, MD 2, Dr. An- 631 Decreasing Risk Of Infection and Severity Of Infections Result- dres Franco, MD 1, Dr. Esmeralda Delgado, MD 3 and Dr. Sagrario ing In Hospitalizations In Patients With Primary Immunodefi- Bustabad, MD 3, 1Immunology, Hospital Universitario de Canarias, ciency Disease Changing From IVIG To Scig Therapy LA LAGUNA, Spain, 2Allergy Section, Hospital Ofra, Tenerife, Mr. Art Zbrozek, RPh, MSc, MBA 1, Ms. Sonam Mehta 2, Dr. Spain, 3Rheumatology, Hospital Universitario de Canarias, LA LA- Dipen A. Patel 2 and Mr. Marc Botteman, MSc 2, 1CSL Behring GUNA, Spain LLC, King of Prussia, PA, 2Pharmerit International, Bethesda, MD 640 Circulating Endothelial and Platelet Microparticles For Diag- 632 A Multicenter Non-Interventional Study On The Efficacy and nosis and Monitoring Vasculitis Tolerability Of The Polyvalent Intravenous Immunoglobulin Prof. El-Desouki E. Fouda, MD, FAAAAI , Al-Azhar university Ò Privigen Allergy & Immunology Cr., Cairo, Egypt, Dr. Marwa Ahmed, Al- Dr. Rainer Hoffmann, MD 1, Dr. Peer Lotichius, PhD 2 and Dr. Di- azhar Allergy&Immunology Cr., Cairo, Egypt and Prof. Mona Al- etmar Pfruender, MD 2, 11Praxis fur€ Neurologie und Psychiatrie, rayes, Al-Azhar Allergy& Immunology Cr.,, Cairo, Egypt Berlin, Germany, 2CSL Behring, Hattersheim, Germany 641 Mistaken Identity: Misdiagnosis Based On Auto-Antibodies In 633 The Immunoglobulin Diagnosis, Evaluation, and Key Learnings IVIG (IDEaL) Patient Registry: Analysis Of Ig Dosing, Infection Con- Dr. Kristyn E. Anthony, MD , Tulane University, New Orleans, LA trol, and Quality-Of-Life Assessments In Our Primary Immu- and Dr. Jane M. El-Dahr, MD, Tulane University School of Medi- nodeficiency Population cine, New Orleans, LA Sean Kearns, Ph.D 1, Keith Crawford 1, Loretta Kristofek, RN 1, Rob- 642 Th-17 Cytokines In Oral byn Kirylo 1 and Dr. Luqman Seidu, MD 2, 1Coram Clinical Trials, Den- Prof. G.N. Drannik 1, Prof. A.I. Kurchenko 1, Dr. R.A. Rehuretska 1, ver, CO, 2Allergy and Asthma of Atlanta, LLC, Atlanta, GA Dr. A.G. Drannik 2 and Prof. Lawrence M. DuBuske, MD,

126 J ALLERGY CLIN IMMUNOL Abstracts AB337 VOLUME 133, NUMBER 2

FAAAAI 3, 1National Medical University, Kiev, Ukraine, 2National University, Bangkok, Thailand and Dr. Wisuwat Songnuan, Depart- medical University, Kiev, Ukraine, 3George Washington University ment of Plant Science, Faculty of Science, Mahidol University, School of Medicine, DC Bangkok, Thailand 652 Attitudes and Behaviors Among Patients With Confirmed Pet Allergy Dr. Timothy J. Campbell, MD , Dr. Asaf Klein, MD, Xiaofeng Wang, PhD, Qi Zhang, M.S. and Dr. Roxana Siles, MD, Cleveland Airborne Allergen Exposures Clinic 653 Uniformed Distribution Of Aerosolized Dust Mite Allergen In 4205 The Allergen Biocube (ABC) Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Keith Lane , Ora Inc., MA, Paul Gomes, Ora Inc., Endri Angjeli, 643 A Study On Allergy Sensitization Of Dense Urban Dwellers To Ora, Inc, Andover, MA and Dr. Anne K. Ellis, MD, MSc FAAAAI, Dog and Cat Allergens Using The Skin Prick Test Allergy Research Unit, Kingston General Hospital, Kingston, ON, Dr. Racquel Joy Y. So , Dr. Florecita Padua and Dr. Shirley Kwong, Canada; Departments of Medicine and Biomedical & Molecular Fe Del Mundo Medical Center, Quezon City Science, Queen’s University, Kingston, ON, Canada 644 Rhinixä Nasal Filters For The Treatment Of Allergic Rhinitis: A Randomized, Double-Blinded Placebo-Controlled Crossover Clinical Trial Peter Kenney, BSc 1, Ole Hilberg, MD, DMSc 2, Henrik Pedersen, PhD 3, Ole Bækgaard Nielsen, PhD 4 and Torben Sigsgaard, MD, Infections, Asthma and Allergies PhD 1, 1Department of Public Health, Aarhus University, Aarhus, Denmark, 2Department of Respiratory Diseases and Allergology, 4206 Aarhus University Hospital, Aarhus, Denmark, 3Department of Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Engineering - Signal Processing, Aarhus University, Aarhus, Den- 654 Cytokine Profiles In Bronchoalveolar Lavage In a Mouse Model mark, 4Department of Biomedicine, Aarhus University, Aarhus Of Bronchial Asthma During A(H1N1)pdm09 and Seasonal 645 Airborne Allergen Exposure As a Quantum Phenomenon H1N1 Infection Dr. Gert Doekes, PhD , Institute for Risk Assessment Sciences, Dr. Shunji Hasegawa 1, Dr. Seigo Okada 2, Dr. Hiroyuki Wakiguchi 2, University Utrecht, NL, Utrecht, Netherlands, Dr. Peter S. Thorne, Dr. Hideki Hasegawa 3, Dr. Akira Ainai 4, Dr. Komei Shirabe 5, Dr. Shoi- PhD, University of Iowa, Iowa City, IA, Dr. Ingrid , PhD, In- chi Toda 5, Dr. Ryo Atsuta 6, Dr. Akihiro Hasegawa 7 and Dr. Takashi stitute for Prevention and Occupational Medicine, Ruhr-University Ichiyama 1, 1Department of Pediatrics, Yamaguchi University Graduate Bochum, Bochum, Germany, Dr. Inge Wouters, PhD, Institute for School of Medicine, Ube, Yamaguchi, Japan, 2Department of Pediat- Risk Assessment Sciences, University Utrecht, Utrecht, Nether- rics, Yamaguchi University Graduate School of Medicine, 3Depart- lands, Dr. Wijnand Eduard, PhD, National Institute of Occupational ment of Pathology, National Institute of Infectious Diseases, Health, Oslo, Norway and Dr. Dick Heederik, PhD, Institute for 4Influenza Virus Research Center, National Institute of Infectious Dis- Risk Assessment Sciences, Utrecht, Netherlands eases, 5Yamaguchi Prefectural Institute of Public Health and Environ- 646 Computer-Aided Design Of An Allergen Challenge Theatre ment, 6Department of Respiratory Medicine, Juntendo University William H. Yang, MD , Jimmy Yang, MBA, Robert Perrins, P.Eng, School of Medicine, 7Department of Microbiology and Immunology, Suzanne Kelly, PhD and Jacob , MD, Red Maple Trials Inc., Yamaguchi University Graduate School of Medicine Ottawa, ON, Canada 655 In Vitro Tumor Necrotic Factor Alpha Responses To Persistent 647 Evaluation Of a Compact Ionic Capture Device For Airborne Chlamydia Pneumoniae Infection From PBMC Of Asthmatic Allergens In Inner City Schools Children Dr. Julian Gordon, PhD 1, Ms. Prasanthi Gandhi, MBA MPH 1, Dr. Dr. Kobkul Chotikanatis, MD 1, Dr. Diana Weaver, MD 2, Danielle Gajendra Shekhawat, PhD2, Ms. Ann Bailey, BA 3 and Dr. Wanda Lent3, Eva Estrella 3, Dr. Margaret R. Hammerschlag, MD 3, Dr. Phipatanakul, MD, MS, FAAAAI 4, 1Inspirotec LLC, Chicago, IL, Rauno O. Joks, MD, FAAAAI 1,4 and Dr. Stephan Kohlhoff, MD 5,6, 2Northwestern University, Evanston, IL, 3Channing Laboratory, 1SUNY Downstate Medical Center, Center for Allergy and Asthma Boston, MA, 4Boston Children’s Hospital, Boston, MA Research, Brooklyn, NY, 2Kings County Hospital Center, Brooklyn, 648 Relevance Of Sensitization To Blomia Tropicalis, Dermatopha- NY, 3SUNY Downstate Medical Center, Brooklyn, NY, 4Department goides and Tropomyosin- Containing Antigens Among Atopics of Medicine, State University of New York Downstate Medical Cen- MONDAY Living In a Tropical Region ter, Brooklyn, NY, 5Center for Allergy and Asthma Research, State Dr. Beverly K. Di Giorgi, MD , Dr. Sylvette Nazario, MD, Dr. Fer- University of New York Downstate Medical Center, Brooklyn, NY, nando J. Lopez, MD and Dr. Javier A. Mendez, MD, University of 6Department of Pediatrics, State University of New York Downstate Puerto Rico School of Medicine, San Juan, PR Medical Center, Brooklyn, NY 649 Update In The Prevalence Of Atopic Conditions, IgE Levels and 656 Human Rhinoviruses/Enteroviruses Associated Wheezing In Skin Test Sensitization To Aeroallergens In Northern Puerto Children Rico Anyarat Wanitchakorn, MD 1, Dr. Wiparat Manuyakorn, MD 1, Dr. Rafael H. Zaragoza, MD, PhD , Doral Bank Center, San Juan, Wasu Kamchaisatian, MD 1, Dr. Wasun Chantratita 2, Kanjana Pre- PR; University of Puerto Rico School of Medicine, San Juan, PR mchaiporn2 and Suwat Benjaponpitak, MD 1, 1Division of Pediatric 650 Stability Of Immunoassay Analytes and Test Kits Used For Allergy/Immunology/Rheumatology, Department of Pediatrics, Monitoring Environmental Allergen Exposure Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bryan Smith, Denise Block, Stephanie Filep, Dr. Martin D. Chap- Bangkok, Thailand, 2Department of Pathology, Faculty of Medicine man, PhD FAAAAI and Dr. Eva-Maria King, PhD, Indoor Biotech- Ramathibodi Hospital, Mahidol University, Bangkok, Thailand nologies, Inc., Charlottesville, VA 657 Study Of Montelukast For The Treatment Of Acute and Post 651 Factors Affecting Pollen Rupture and Protein Release From Al- Viral-Induced Wheezing lergenic Pollens Sirirak Kanchanateeraphong, MD , Gun Phongsamart, MD, Tas- Ms. Umaporn Siriwattanakul , Master of Science Program in Plant salapa Dangsuwan, MD and Mukda Vangveeravong, MD, Queen Science, Department of Plant Science, Faculty of Science and De- Sirikit National Institute of Child Health(Children Hospital), Bang- partment of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol kok, Thailand

127 AB338 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

658 Prevalence Of Toxocara Infection In Subjects With Suspected MD 4, Dr. Gianluca Pirozzi, MD, PhD 5, Warren Brooks, PhD 4 Allergies and Dr. Marius Ardeleanu, MD 4, 1Universit€at zu L ubeck,€ Lu- Dr. Rosanna M. Qualizza , Istituti Clinici di Perfezionamento, Mi- beck, Germany, 2Charite - Universit €atsmedizin Berlin, Berlin, lano, Italy, Dr. Cristoforo Incorvaia, Istituti Clinici di perfeziona- Germany, 3Regeneron Pharmaceuticals, Inc., Basking Ridge, NJ, mento, Milano, Italy and Dr. Anna Maraschini, IRCCS 4Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 5Sanofi, Fondazione Ca’Granda Policlinico, Milano, Italy Bridgewater, NJ 659 The Effects Of Dexamethasone On Community-Acquired Pneu- 665 A Lipid Plant Extract From Chamaecyparis Obtusa Induces monia In Children Filaggrin and Human Beta-Defensin -3 Prof. Youn Ho Shin , Department of Pediatrics, CHA Medical Cen- Mr. Byung Eui Kim, MD, PhD 1, Mr. Gwui Cheol Kim, PhD 2, Ms. ter, CHA University School of Medicine, Seoul, Korea, South Ko- Hee Jin Kim2 and Donald Y.M. Leung, MD, PhD, FAAAAI 1, 1Na- rea, Dr. Jun Hwan Kim, Department of Pediatrics, CHA University tional Jewish Health, Denver, CO, 2Jeonnam Nano Bio Research School of Medicine, South Korea, Dr. Jung Won Yoon, Department Center of Pediatrics, Myongji Hospital, Gyeonggi-do, South Korea, Prof. 666 Identification Of Novel Gene Signatures In Atopic Dermatitis Sun-Hee Choi, MD, PhD, Gangdong Kyung Hee University Hospi- Complicated By Eczema Herpeticum tal, Seoul, South Korea, Dr. Hyeung Yoon Kim, Department of Pe- Dr. Lianghua Bin, MD, PhD 1, Dr. Michael G Edwards 2, Dr. Ryan diatrics, Bundang Jaesaeng Hospital, Seongnam, South Korea, Hye Heiser, PhD 1, Mrs. Joanne Streib, BA 1, Ms. Brittany Richers 1 and Mi Jee, MD, Department of Pediatrics, CHA University School of Donald Y.M. Leung, MD, PhD, FAAAAI 1, 1National Jewish Medicine, Seongnam, Korea, South Korea, Prof. Man-Yong Han, Health, Denver, CO, 2University of Colorado at Denver MD, PhD, Department of Pediatrics, CHA University School of 667 Topical Application Of Rapamycin Ointment Inhibits Dermato- Medicine, Seongnam, South Korea and Dr. Jin-Tack Kim, MD, phagoides Farinae Body (Dfb) Extract Antigen-Induced Derma- PhD, Department of Pediatrics, Uijeongbu St. Mary’s Hospital, titis In NC/Nga Mice The Catholic University of Korea, College of Medicine, Uijeongbu, Mr. Fei Yang 1, Dr. Lingli Yang 1, Dr. Mari Tanaka 1, Dr. Mari Gyeonggi-Do, South Korea Wataya-Kaneda 1, Ayumi Nakamura 2, Shoji Matsumoto 2, Dr. 660 The Association Between Strongyloides Stercoralis Infection Mostafa Attia3, Dr. Hiroyuki Murota 1 and Prof. Ichiro Ka- and Allergic Skin Diseases tayama1, 1Department of Dermatology, Course of Integrated Dr. Lahari Rampur, MD , Albert Einstein/Jacobi medical centre, Medicine, Graduate School of Medicine, Osaka University, Bronx, NY, Dr. Gabriele De Vos, MD, Albert Einstein College of Osaka, Japan, Osaka, Japan, 2Osaka University Hospital, Depart- Medicine, Bronx, NY, Dr. Golda Hudes, MD, PhD, Albert Einstein/ ment of Pharmacy, Osaka, Japan, 3Dermatology, Cairo Univer- Montefiore Medical Center, New York, NY and Dr. Sunit Jariwala, sity, Cairo, Egypt, Cairo, Egypt MD, Albert Einstein/Montefiore Medical Center, New York, NY 668 Therapeutic Effects Of Recombinant Salmonella Typhimurium 661 Effects Of Human Rhinovirus Species On Cytokine Production Expressing TLR8 miRNA On Atopic Dermatitis and Cellular Cytotoxicity In Differentiated Sinus Epithelial Dr. Wonsuck Yoon , Department of Life Science and Biotechnol- Cells ogy, Seoul, South Korea, Prof. Ji Tae Choung, MD, Korea Univ. Dr. Kazuyuki Nakagome, MD 1,2, Dr. Yury Bochkov, PhD 1, Dr. Medical Center, Seoul and Dr. Young Yoo, MD, PhD, Department 1 1

MONDAY Shamaila Ashraf, PhD , Ms. Rebecca Brockman-Schneider, MS of Pediatrics, College of Medicine, Korea University, Seoul, South and Dr. James E. Gern, MD, FAAAAI 1, 1University of Wisconsin Korea School of Medicine and Public Health, Madison, WI, 2Saitama 669 Correlation Between Serum 25-Hydroxyvitamin D Levels and Medical University, Saitama, Japan Severity Of Allergic Atopic Dermatitis In Children 662 Human Rhinovirus Bronchiolitis Predominant In Very Low Dr. Sung Soon , BUSAN MARY, BUSAN, South Korea Birthweight Infants In Argentina 670 Association Between Prenatal and Early Life Vitamin D Levels Dr. Jodell E Linder-Jackson, PhD 1, Tatyana E Plachco 2, Lucrecia and Allergic Outcome At Age 2 Years Bossi3, Gabriela Bauer 2, Fernando P Polack 4, Romina P Libster 5 Ganesa Wegienka, PhD 1, Ms. Suzanne Havstad, M.A. 1, Kimber- and Eva K Kathryn Miller, MD, MPH 6, 1Vanderbilt, TN, 2Hospital ley J. Woodcroft, PhD 1, Dr. Dennis Ownby, M.D. FAAAAI 2, Dr. de Pediatr ıa Garrahan, Argentina, 3Maternidad Sarda, Argentina, Edward M. Zoratti, MD, FAAAAI 3 and Dr. Christine Cole Johnson, 4Fundacion Infant, Vanderbilt University, Argentina, 5Fundacion PhD MPH FAAAAI 1, 1Department of Public Health Sciences, Infant, Argentina, 6Vanderbilt University Medical Center, Nash- Henry Ford Hospital, Detroit, MI, 2Department of Pediatrics Geor- ville, TN gia Regents University, Augusta, GA, 3Henry Ford Health System, 663 Association Of Vitamin D Status With Recurrent Wheezers and Detroit, MI Lower Respiratory Infection In Pre-School Children 671 Association Between Sun Exposure During The First 6 Months Prof. Jin-A Jung, MD , Dong-A University College of Medicine, Of Life and The Cumulative Incidence Of Atopic Dermatitis In Busan, Prof. Ja Hyeong Kim, MD, Ulsan University Hospital, Ul- Infants san, South Korea and Prof. Ju-Suk Lee, MD, PhD, Sungkyunkwan Dr. Miwa Shinohara, MD, PhD , Department of Pediatric Allergy university, Changwon, South Korea and Clinical Research, Shimoshizu National Hospital, Yotsukaido, Japan and Dr. Kenji Matsumoto, MD, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan 672 Dampness In The Water-Damaged Homes Affects The Severity Immune Mediated Skin Diseases Of Atopic Dermatitis In Children Prof. Sungchul Seo , The Enviornmental Health Center for Asthma, 4207 Korea University, Seoul, Prof. Ji Tae Choung, MD, Korea Univ. Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Medical Center, Seoul, Dr. Young Yoo, MD, PhD, Department of 664 Safety and Efficacy Of Dupilumab Versus Placebo For Moder- Pediatrics, College of Medicine, Korea University, Seoul, South ate-To-Severe Atopic Dermatitis In Patients Using Topical Cor- Korea, Dr. Wonsuck Yoon, Department of Life Science and Bio- ticosteroids (TCS): Greater Efficacy Observed With technology, Seoul, South Korea, Prof. Kangmo Ahn, MD, PhD, De- Concomitant Therapy Compared To TCS Alone partment of Pediatrics, Samsung Medical Center, Sungkyunkwan Dr. Diamant Thaci, MD 1, Dr. Margitta Worm, MD 2, Dr. Haobo University School of Medicine, Seoul, South Korea and Dr. Jihyun Ren, PhD3, Dr. Steven Weinstein, MD, PhD 4, Dr. Neil Graham, Kim, MD, Samsung Medical Center, Seoul

128 J ALLERGY CLIN IMMUNOL Abstracts AB339 VOLUME 133, NUMBER 2

673 Mycotoxin Aggravates Atopic Dermatitis Via TSLP Induced Hospital, 2Gangdong Kyung Hee University Hospital, Seoul, South Th2 Inflammation Korea Ms. Seung-Hwa Lee1, Ms. Ha-Jung Kim 1 and Prof. Soo-Jong 682 Excellent Agreement Between Dermatology and Pediatric Re- Hong, MD. PhD2,3, 1Asan Institute for Life Sciences, University searchers In Severity Scoring Of Atopic Dermatitis (SCORAD) of Ulsan College of Medicine, 2Department of Pediatrics, Asan Index In Children Medical Center, Childhood Asthma Atopy Center, South Korea, Dr. Rodrigo Hoyos Bachiloglu, MD 1, Dr. Cristian Navarrete, 3Research Center for Standardization of Allergic Disease, Univer- MD 2, Dr. Cristian Vera, MD 2, Dr. Sergio Silva, MD 2, Dr. Lorena sity of Ulsan College of Medicine, Seoul, Korea Cifuentes, MD 1, Mrs. Carolina Iturriaga, RN 1, Ms. Francisca Cristi, 674 Early Skin Care By ‘‘Experienced Mothers’’ May Prevent Sen- MSc1 and Dr. Arturo Borzutzky, MD 1, 1Division of Pediatrics, sitization In Infants With Atopic Dermatitis School of Medicine, Pontificia Universidad Catolica de Chile, San- Dr. Atsushi Yamashita , Dr. Mizuho Nagao, MD, Ms. Kanae Fur- tiago, Chile, 2Department of Dermatology, School of Medicine, uya, Dr. Junya Hirayama, Dr. Keigo Kainuma, MD and Dr. Takao Pontificia Universidad Catolica de Chile, Santiago, Chile Fujisawa, MD, FAAAAI, Institute for Clinical Research, Mie Na- 683 A Case Of Recurrent Severe Poison Ivy Contact Dermatitis, tional Hospital Treated Successfully With Seasonal Cyclosporine 675 Association Of Bathing Habits To Pruritus and Allergic Disease Dr. Jaron T. Abbott, MD , Dr. Yuriy Zgherea, MD and Dr. Selina Dr. Kanwaljit K. Brar, MD 1, Dr. Rauno O. Joks, MD, FAAAAI 2 Gierer, DO, University of Kansas Medical Center and Dr. Hamid Moallem, MD 1, 1SUNY Downstate Medical Center, 684 Allergic Contact From Orthodontic Adhesives Brooklyn, NY, 2Center for Allergy and Asthma Research, State Dr. Priscilla H. Wong, MD 1, Dr. Scott D. Dickson, DO 2 and Dr. University of New York Downstate Medical Center, Brooklyn, NY Christopher A. Coop, MD 1, 1Wilford Hall Ambulatory Surgical 676 A Molecular Mechanism Underlying Atopic Dermatitis In Hy- Center, Lackland AFB, TX, 256th Medical Group, Luke AFB, AZ per-IgE Syndrome 685 Contact Dermatitis Due To Topical Amorolfine Masako Saito, PhD , Division of Molecular Medicine, Institute for Dr. Ruperto Gonzalez Perez , Mrs. Paloma Poza-Guedes, Mrs. In- Genome Research, The University of Tokushima, Tokushima, Ja- maculada Sanchez Machın and Dr. Victor Matheu, MD, Hospital pan, Dr. Hajime Karasuyama, MD, PhD, Tokyo Medical and Den- del Torax-Ofra, Sta Cruz de Tenerife, Spain tistry Graduate School, Tokyo, Japan and Dr. Yoshiyuki Minegishi, 686 Sweet’s Syndrome By A Show Of Hands MD and PhD, Division of Molecular Medicine, Institute for Ge- Dr. Syeda Hamadani , Dr. Anita Ravi, Dr. Seth Politano, Dr. Eric nome Research, The University of Tokushima Hsieh and Dr. Gina Rossetti, USC, Los Angeles, CA 677 Racial Differences In The Relationship Of Total and Food-Spe- 687 , Pulp Fiction? cific IgE To Atopic Dermatitis In Childhood Dr. Alexander S. Kim, MD , University of California San Diego, Dr. Gillian Bassirpour, MD 1, Dr. Edward M. Zoratti, MD, La Jolla, CA and Dr. Sandra C. Christiansen, MD, FAAAAI, South- FAAAAI 2, Ganesa Wegienka, PhD 3, Ms. Suzanne Havstad, ern CA Permanente Med Grp, San Diego, CA M.A.3, Alexandra Sitarik, M.S. 3, Dr. Haejin Kim, MD 1, Dr. Dennis 688 Preoperative Patch Testing In Patients Undergoing Pectus Ex- Ownby, M.D. FAAAAI 4 and Dr. Christine Cole Johnson, PhD MPH cavatum Repair FAAAAI 3, 1Division of Allergy and Clinical Immunology, Henry Dr. Laura Helfner, MD 1, Dr. David Rosenthal, DO 1, Dr. Blanka Ford Hospital, Detroit, MI, 2Henry Ford Health System, Detroit, M. Kaplan, MD, FAAAAI 2 and Dr. Punita Ponda, MD, FAAAAI 3, MI, 3Department of Public Health Sciences, Henry Ford Hospital, 1Division of Allergy/Immunology, Departments of Medicine and Detroit, MI, 4Department of Pediatrics Georgia Regents University, Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Augusta, GA Neck, NY, 2Department of Pediatrics, Division of Allergy & Immu- 678 Major Culprit Allergen Sensitization Patterns According To nology, Hofstra-North Shore-LIJ School of Medicine, Great Neck, Age In Korean Atopic Dermatitis Patients NY, 3Allergy and Immunology, North Shore LIJ Health System, Hye Jung Park 1, Jae-Hyun Lee 1,2, Kyung-Yong Jeong 2, Kyung- Great Neck, NY Hee Park1,2, Yoon-Ju Kim 2 and Jung-Won Park 1,2, 1Division of Al- lergy and Clinical Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Insti- tute of Allergy, Yonsei University College of Medicine, Seoul, South Korea Food Allergy II 679 Protein Microarray: IgE-Profiling Of Brazilians With Atopic Dermatitis 4208 MONDAY Lucila Camargo Lopes de Oliveira 1, Roberta Faria Camilo-Ara- Monday, March 3rd, 2014, 9:45 AM - 10:45 AM ujo 1, Isabel Rugue Genov 1, Dr. Renata R. Cocco 2, Dr. Marcia Mal- 689 Oral Allergy Syndrome - a Spectrum Of Presentations lozi, MD 3, Prof. Nelson A. Rosario, MD, PhD, FAAAAI 4 and Prof. Dr. Parwinder Gill 1, Dr. Gordon L. Sussman, FAAAAI 2, Jiayi Dirceu Sole, MD, PhD5, 1UNIFESP, 2Federal University of S ~ao Bian1 and Ms. Carly Barron3, 1University of Toronto, Toronto, Paulo, 3Federal University of S ~ao Paulo, Brazil, 4Federal University ON, Canada, 2University of Toronto, Faculty of Medicine, Toronto, of Parana, Curitiba, Brazil, 5Federal University of Sao Paulo, Sao ON, Canada, 3Gordon Sussman Clinical Research Inc., Toronto, Paulo, Brazil ON, Canada 680 Relationship Between Dietary Food and Nutrient Intakes and 690 Allergy To Sheep Milk With Or Without Allergy To Cow Milk Bone Mineral Density In Childhood Eczema Dr. Fouseena Pazheri 1, Dr. Alton Lee Melton Jr., MD 2, Dr. Earl Dr. Ting Fan Leung, MD FRCPCH FAAAAI , Ms. Flora Yin-ying Poptic1 and Dr. Belinda Willard 1, 1Cleveland CLinic, Cleveland, Kwok, MPhil, Dr. Yvonne Yi-fong Ho, MPhil, Dr. Susan Shuxin OH, 2Cleveland Clinic, Cleveland, OH Wang, PhD, Ms. Patty Pui-pui Tse, MSc, Prof. Gary Wing-kin 691 Genome-Wide Study Of Interaction Between Season Of Birth Wong, MD, FRCPC and Dr. Kam Lun Ellis Hon, MD, FAAP, De- and Peanut Allergy Identifies a Region On 3 As partment of Paediatrics, The Chinese University of Hong Kong, a Genetic Risk Factor Hong Kong Corinne Keet, MD, MS 1, Xiumei Hong, PhD 2, Dr. Ingo Ruczinski, 681 Change Of Caregiver’s Perception Regarding Atopic Dermati- PhD2, Dr. Terri H Beaty, PhD 2, Dr. Jacqueline Pongracic, MD, tis From 2006 To 2013 FAAAAI 3 and Dr. Xiaobin Wang, MD, MPH ScD 4, 1Pediatrics, Dr. Kyung Suk Lee, MD, PhD 1, Prof. Yeong-Ho Rha, MD, PhD 1 Johns Hopkins University School of Medicine, Baltimore, MD, and Prof. Sun-Hee Choi, MD, PhD2, 1Kyung Hee University 2Johns Hopkins University School of Public Health, Baltimore,

129 AB340 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

MD, 3Ann & Robert H. Lurie Children’s Hospital of Chicago, Chi- Baltimore, MD, 4Johns Hopkins University Medical Center, Balti- cago, IL, 4Center on Early Life Origins of Disease, Department of more, MD Population, Family and Reproductive Health, Johns Hopkins Uni- 697 Prevalence Of IgE-Mediated Food Sensitisation and Food Al- versity Bloomberg School of Public Health, Baltimore, MD lergy In Unselected 12-36 Month Old South African Children 692 Orofecal Infections and Risk Of Food Allergy In Children Dr. Maresa Botha, MBChB, FCPaed 1 and Prof. Michael E. Levin, Dr. Gary Wong, MD 1, Dr. Jing Li, MD, MSc 2, Dr. Ting Fan Leung, MBChB, FCPaed, Dip Allergology, MMed(Paeds), PhD, EAACI MD FRCPCH FAAAAI 3 and Prof. Nanshan Zhong2, 1Chinese Uni- allergy exam (UEMS), Certificate Allergology, FAAAAI 1,2, 1Uni- versity of Hong Kong, Shatin, Hong Kong, 2The First Affiliated versity of Cape Town, Cape Town, South Africa, 2Red Cross War Hospital of Guangzhou Medical College, State Key Laboratory of Memorial Children’s Hospital, Cape Town, South Africa Respiratory Disease, Guangzhou Institute of Respiratory Disease, 698 Evaluation Of Peanut Allergy In a Birth Cohort Guangzhou, China, 3Department of Paediatrics, The Chinese Uni- Dr. Hiba Bashir, MD 1, Mr. Christopher J. Tisler, MT 1, Dr. Eliza- versity of Hong Kong, Hong Kong beth L. Anderson 1, Dr. Theresa Kang, PhD 1, Lisa Salazar, BS 1, 693 Peanut, Milk, and Wheat Intake During Pregnancy Is Associ- Mr. Michael D. Evans, MS 1, Dr. Ronald E. Gangnon, PhD 1, Dr. ated With Reduced Allergy and Asthma In Children Daniel J. Jackson, MD 2, Dr. Robert F. Lemanske Jr., MD, FAAAAI 1 Dr. Supinda Bunyavanich, MD, MPH 1, Ms. Sheryl Rifas-Shiman, and Dr. James E. Gern, MD, FAAAAI 1, 1University of Wisconsin MPH2, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 3, Lisa J. School of Medicine and Public Health, Madison, WI, 2Pediatrics, Workman, BA 3, Dr. Joanne Sordillo, ScD 4, Dr. Carlos Camargo University of Wisconsin School of Medicine and Public Health, Jr., MD, DrPH 5, Dr. Matthew Gillman, MD, SM 2, Dr. Diane R. Madison, WI Gold, MD, MPH6 and Dr. Augusto A. Litonjua, MD, MPH 4, 1Divi- 699 Prevalence Of Peanut Allergy: A Systematic Review sion of Pediatric Allergy & Immunology, Department of Pediatrics, Dr. Heather Mackenzie 1, Dr. Carina Venter, PhD RD 2, Dr. Sally Icahn School of Medicine at Mount Sinai, New York, NY, 2Depart- Kilburn1, Ms. Harriet R. Moonesinghe 1, Ms. Kellyn Lee 1 and ment of Population Medicine, Harvard Pilgrim Health Care Insti- Prof. Taraneh Dean 1,3, 1University of Portsmouth, School of Health tute, Harvard Medical School, Boston, MA, 3Division of Asthma, Sci, Portsmouth, United Kingdom, 2The David Hide Asthma and Allergy & Immunology, University of Virginia Health System, Allergy Research Center, Isle of Wight, United Kingdom, 3The Da- Charlottesville, VA, 4Channing Division of Network Medicine, vid Hide Asthma and Allergy Centre, Newport Brigham & Women’s Hospital, Harvard Medical School, Boston, 700 Prevalence Of Fish and Shellfish Allergy- A Systematic Review MA, 5Department of Emergency Medicine, Massachusetts General Ms. Harriet R. Moonesinghe 1, Dr. Sally Kilburn 1, Dr. Heather Hospital, Harvard Medical School, Boston, MA, 6Channing Labo- Mackenzie1, Dr. Paul J. Turner, FRACP PhD 2, Dr. Carina Venter, ratory, Brigham and Women’s Hospital, Boston, MA PhD RD 3, Ms. Kellyn Lee 1 and Prof. Taraneh Dean 1, 1University 694 The Prevalence Of Food Sensitization and Food Allergy In An of Portsmouth, School of Health Sci, Portsmouth, United Kingdom, Inner City Birth Cohort 2Imperial College London, United Kingdom, 3The David Hide Robert A. Wood, MD, FAAAAI , Johns Hopkins University Med- Asthma and Allergy Research Center, Isle of Wight, United ical Center, Baltimore, MD, Dr. Emily C. McGowan, MD, Johns Kingdom Hopkins University School of Medicine, Baltimore, MD, Dr. Gor- 701 Prevalence Of Food Allergy To Uncommon Foods Based On

MONDAY don R. Bloomberg, MD, FAAAAI, Campus Box 8116, St. Louis Oral Food Challenges Children’s Hospital, Saint Louis, MO, Dr. Peter J. Gergen, MD, Dr. Gita Ram 1, Christina Gustafson 1, Dr. Jonathan M. Spergel, MPH, AAIB\DAIT\NIH, Bethesda, MD, Dr. Cynthia Visness, MD, PhD, FAAAAI 2 and Dr. Antonella Cianferoni, MD, PhD 3, PhD, Rho Federal Systems Division, Inc., Chapel Hill, NC, Katy 1Children’s Hospital of Philadelphia, Philadelphia, PA, 2The Chil- Jaffee, MS, Rho, Inc., Chapel Hill, NC, Dr. George T. O’Connor, dren’s Hospital of Philadelphia, Philadelphia, PA, 33615 Civic Cen- MD, Boston University School of Medicine, Boston, MA, Dr. ter Boulevard, The Children’s Hospital of Philadelphia, Meyer Kattan, MD, NewYork-Presbyterian/Columbia, New York, Philadelphia, PA NY and Dr. James E. Gern, MD, FAAAAI, University of Wisconsin 702 Prevalence Of Food Allergy In Patients With Irritable Bowel School of Medicine and Public Health, Madison, WI Syndrome 695 Food Allergy Prevalence In Parents Of Food-Allergic Children Erin L. Reigh, MD, MS 1, Dr. Javed Sheikh, MD, FAAAAI 2 and Based On Self-Report, Serologic Testing and Physician Diagno- Anna Kovalszki, MD 1, 1Beth Israel Deaconess Medical Center, sis Boston, MA, 2Kaiser Permanente Los Angeles Medical Center, Melanie M. Makhija, MD 1,2, Dr. Rachel Glick Robison 2,3, Deanna Los Angeles, CA Caruso, MS 4, Miao Cai, MS 5, Dr. Xiaobin Wang, MD, MPH ScD 4 703 Clinical Characteristics Of Seafood Allergy In Canadian Chil- and Dr. Jacqueline Pongracic, MD, FAAAAI 3,6, 1Ann and Robert dren H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Division Dr. Victoria Cook , Department of Pediatrics, University of British of Allergy & Immunology, Department of Pediatrics,Northwestern Columbia, BC Children’s Hospital, Vancouver, BC, Canada, Dr. University Feinberg School of Medicine, Chicago, IL, 3Ann & Rob- Edmond S. Chan, MD, FAAAAI, Department of Pediatrics, Faculty ert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 4Johns of Medicine, University of British Columbia, Dr. Ann Elaine Hopkins University School of Public Health, Baltimore, MD, 5Di- Clarke, MD, MSc, Division of Allergy and Clinical Immunology, vision of Allergy & Immunology, Department of Pediatrics, North- Department of Medicine, McGill University Health Centre, Mon- western University Feinberg School of Medicine, Ann & Robert H. treal, QC, Canada; Division of Clinical Epidemiology, Department Lurie Children’s Hospital of Chicago, Chicago, IL, 6Division of Al- of Medicine, McGill University Health Centre, Montreal, QC, Can- lergy & Immunology, Department of Pediatrics,Northwestern Uni- ada, Mr. Greg Shand, Department of Medicine, Division of Clinical versity Feinberg School of Medicine Epidemiology, McGill University Health Center, Montreal, QC, 696 The Effect Of Neighborhood Level Poverty and Urbanization Canada and Dr. Moshe Ben-Shoshan, MD, MSc, Division of Paedi- On The Prevalence Of Food Allergy In The National Health In- atric Allergy and Clinical Immunology, Department of Paediatrics, terview Survey (NHIS) McGill University Health Center, Montreal, QC, Canada Dr. Emily C. McGowan, MD 1, Dr. Meredith C. McCormack, 704 Changes In Total IgE Levels To Predic Food Challenge Test MD 2, Dr. Roger Peng, PhD 3, Dr. Elizabeth Matsui, MD 2 and Cor- Outcomes inne Keet, MD, MS 4, 1Johns Hopkins University School of Medi- Dr. Kenta Horimukai , Jikei University Katsushika Medical Cen- cine, Baltimore, MD, 2The Johns Hopkins University School of ter, Tokyo, Japan, Dr. Masami Narita, MD, PhD, National Center Medicine, Baltimore, MD, 3Johns Hopkins School of Public Health, for Child Health and Development, Tokyo, Japan, Dr. Ichiro

130 J ALLERGY CLIN IMMUNOL Abstracts AB341 VOLUME 133, NUMBER 2

Nomura, MD, PhD, National Center for Child Health and Develop- Directorate, Health Canada, Ottawa, ON, Canada, 7McGill Univer- ment, Setagayaku, Japan, Dr. Kenji Matsumoto, MD, PhD, Depart- sity, Dorval, QC, Canada, 8Division of Clinical Epidemiology, De- ment of Allergy and Immunology, National Research Institute for partment of Medicine, McGill University Health Centre, Montreal, Child Health and Development, Tokyo, Japan and Dr. Yukihiro QC, Canada, 9McGill University, Montreal, QC, Canada, 10 Divi- Ohya, MD, PhD, Division of Allergy, National Center for Child sion of Clinical Epidemiology, Department of Medicine, McGill Health and Development, Tokyo, Japan University Health Center, QC, Canada, 11 Department of Geogra- 705 Situational and Environmental Factors Associated With a phy, University of Toronto, Toronto, ON, Canada, ON, Canada, Child’s Willingness To Use An Epinephrine Auto-Injector 12 Applied Health Sciences, University of Waterloo, ON, Canada, Amanda Tantleff , Byram Hills High School and Dr. Anna H. 13 McGill University Health Centre, Montreal, Canada Nowak-Wegrzyn, MD, FAAAAI, Icahn School of Medicine at 710 Differences In Empowerment and Quality Of Life Among Mount Sinai, New York, NY Mothers and Fathers Of Children With Food Allergy 706 Possession Of Epinephrine Auto-Injectors (EAI) In a Vulnera- Mr. Christopher Warren, BA 1, Dr. Ruchi Gupta, MD, MPH 2, Mr. ble Canadian Population With Food Allergies Namit Lal3, Dr. Min-Woong Sohn, PhD 4, Dr. Craig Garfield, MD 4, Dr. Sabrine Cherkaoui, M.D 1, Ms. Lianne Soller, MSc 2, Dr. Dr. Jacqueline Pongracic, MD, FAAAAI 2 and Dr. Xiaobin Wang, Moshe Ben-Shoshan, MD, MSc3, Daniel Harrington, MA, PhD 4, MD, MPH ScD5, 1University of Southern California, Los Angeles, Dr. Sebastien La Vieille, MD 5, Dr. Joseph Fragapane, MD 6, Dr. CA, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, Chi- Lawrence Joseph, PhD7, Mr. Yvan St-Pierre, MSc 8, Prof. Susan El- cago, IL, 3University of Michigan, Ann Arbor, MI, 4Northwestern liott, PhD9 and Dr. Ann Elaine Clarke, MD, MSc 7,10, 1Division of University, Chicago, IL, 5Johns Hopkins, Chicago, IL Internal Medicine, Department of Medicine, University of Mon- 711 Prevalence Of Misconceptions Regarding Egg Allergy and Mea- treal, Montreal, QC, Canada, 2Division of Clinical Epidemiology, sles Mumos and Rubella Vaccine Contraindications Department of Medicine, McGill University Health Center, Mon- Dr. Vylma Velazquez, MD , Dr. Carmen Rivera and Dr. Monique treal, QC, Canada, 3Division of Paediatric Allergy and Clinical Im- Adorno, Hospital Episcopal San Lucas, Ponce, PR munology, Department of Paediatrics, McGill University Health 712 Prenatal and Postnatal Factors Associated With IgE-Mediated Center, Montreal, QC, Canada, 4McMaster University - School of Wheat Allergy In Infants: A Study In Asian Population Geography, Hamilton, ON, Canada, 5Food Directorate, Health Can- Dr. Suparat Sirivimonpan, MD , Chulalongkorn University, Bang- ada, Ottawa, ON, Canada, 6McGill University, Dorval, QC, Canada, kok, Thailand 7Division of Clinical Epidemiology, Department of Medicine, 713 Maternal Healthy Diet and Development Of Allergic Disease McGill University Health Centre, Montreal, QC, Canada, 8Division Dr.Carina Venter, PhD RD 1, Ms. Harriet R. Moonesinghe 2, Prof. Ha- of Clinical Epidemiology, Department of Medicine, McGill Univer- san Arshad 3,4 , Prof. Taraneh Dean 2,5 , Mrs. Jane Grundy 3, Mrs. Gill sity Health Center, Canada, 9Applied Health Sciences, University of Glasbey 3 and Dr. Veeresh Patil 3,4 , 1The David Hide Asthma and Al- Waterloo, ON, Canada, 10 Division of Allergy and Clinical Immu- lergy Research Center, Isle of Wight, United Kingdom, 2University nology, Department of Medicine, McGill University Health Centre, of Portsmouth, School of Health Sci, Portsmouth, United Kingdom, Montreal, QC, Canada 3The David Hide Asthma and Allergy Centre, Newport, United King- 707 Food Allergy In Daycare Centers: Prevalence, Management, dom, 4University of Southampton, Southampton, United Kingdom, and Knowledge Of Directors 5The David Hide Asthma and Allergy Centre, Newport Dr. Lisanne Newton, M.D. and Dr. Brian Schroer, MD, Cleveland 714 Effect Of Annual Income On Parental/Family Burden Of Food Clinic, Cleveland, OH Allergy 708 Assessment Of Food Insecurity and Health Literacy In a Ter- Dr. David A. Petty, DO , University of Tennessee Allergy fellow- tiary Care Pediatric Allergy Population ship program, Memphis, TN, Jay A. Lieberman, MD, University Dr. Meredith A. Dilley, MD 1,2, Ms. G. Lynn Christie, MS RD 2, of Tennessee, Memphis, TN and Nhu Quynh Tran, PhD, University Ms. Mary Price2, Ms. Connelly Weeks 2, Mallikarjuna Rettiganti, of Tennessee Department of Preventative Medicine PhD1,2, Maria Melguizo Castro 1,2, Dr. Amy M. Scurlock, MD 3,4, 715 Food Allergy and Anaphylaxis Educational Needs Assessment, Dr. Tamara T. Perry, MD 1,2, Dr. Robbie D. Pesek 1,2, Dr. Matthew Training Curriculum and Assessment Of Knowledge Of Urban C. Bell, MD 1,2, Joshua L. Kennedy, MD 5, Ms. Erin O’Brien 1,2, Child Care Center Workers Ms. Sklar McGrath2, Mr. Jared Hogan 2, Megan Patterson 1, Julia Ar- Dr. Bruce J. Lanser, MD 1, Dr. Ronina A. Covar, MD 1, David onson1, Dr. Patrick Casey, MD 1,2 and Stacie M. Jones, MD 3,5, 1Uni- Mark Fleischer, MD, FAAAAI 1 and Dr. J. Andrew Bird, MD, versity of Arkansas for Medical Sciences, Little Rock, AR, FAAAAI 2, 1National Jewish Health, Denver, CO, 2UT Southwest- 2Arkansas Children’s Hospital, Little Rock, AR, 3University of Ar- ern Medical Center, Dallas, TX MONDAY kansas for Medical Sciences and Arkansas Children’s Hospital, Lit- 716 Food Allergy Survey Among Food Service Workers tle Rock, AR, 4University of Arkansas for Medical Sciences/ Bruce M. Prenner, MD 1, John Hollingsworth, PA 2, Ron Oliver 3 Arkansas Children’s Hospital, Little Rock, AR, 5Arkansas Chil- and Linnet Brew, LVN 1, 1Allergy Partners of San Diego, San dren’s Hospital Research Institute, Little Rock, AR Diego, CA, 2Scripps Clinic, 3The Marine Room, La Jolla, CA 709 Environmental and Sociodemographic Factors Associated With 717 Bullying and Food Allergy – Longitudinal Follow-Up Food Allergy: A Nested Case-Control Study Scott H. Sicherer, MD, FAAAAI 1, Melissa Rubes 2, Chloe Mullar- Dr. Moshe Ben-Shoshan, MD, MSc 1,2, Ms. Lianne Soller, MSc 3, key2, Mordechai Ambrose 3, Noga Ravid 2, Kelley Chuang 3, Rachel Daniel Harrington, MA, PhD4, Ms. Megan Knoll, MSc 5, Dr. Sebas- Annunziato2 and Eyal Shemesh3, 1Mount Sinai School of Medicine, tian La Vieille, MD 6, Dr. Joseph Fragapane, MD 7, Dr. Lawrence New York, NY, 2Fordham University, NY, 3Icahn School of Medi- Joseph, PhD8,9, Mr. Yvan St. Pierre, MSc 10 , Dr. Kathi Wilson 11 , cine at Mount Sinai, NY Prof. Susan Elliott, PhD12 and Dr. Ann Elaine Clarke, MD, 718 Prevalence and Characteristics of Consumer-Reported Food MSc8,13, 1Division of Paediatric Allergy and Clinical Immunology, Allergic and Anaphylactic Events in CAERS, 2007-2011 Department of Paediatrics, McGill University Health Center, Mon- Ms. Taiye M Oladipo, MPH and Dr. Stefano Luccioli, MD, treal, QC, Canada, 2Montreal Children’s Hospital, Montreal, Can- FAAAAI, Center for Food Safety and Applied Nutrition, Food ada, 3Division of Clinical Epidemiology, Department of and Drug Administration, College Park, MD Medicine, McGill University Health Center, Montreal, QC, Can- 719 Impact Of School Peanut-Free Guidelines On Epinephrine Ad- ada, 4McMaster University - School of Geography, Hamilton, ministration ON, Canada, 5Division of Clinical Epidemiology, Department of Dr. Lisa M. Bartnikas, MD 1,2, Dr. Michelle F. Huffaker, MD 1,3, Medicine, McGill University Health Center, Canada, 6Food Dr. William J. Sheehan, MD 1,2, Dr. Watcharoot Kanchongkittiphon,

131 AB342 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

MD, PhD1,2, Mr. Carter Petty, MA 2, Ms. Anne Sheetz, RN, BSN, 728 Allergy In Children Evaluated Using Double Blind Pla- MPH4, Dr. Robert Leibowitz, PhD 4, Dr. Michael C. Young, MD, cebo Controlled Food Challenge FAAAAI 1,2 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI 1,2, Aysen Bingol , TURPEDAS, Turkey, Dilara Kocacik Uygun, AK- 1Harvard Medical School, Boston, MA, 2Boston Children’s Hospi- DENIZ UNIVERSITY MEDICAL FACULTY DEPT OF PEDIAT- tal, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA, RIC ALLERGY IMMMUNOLOGY, Dr. Serkan Filiz, AKDENIZ 4Massachusetts Department of Public Health, Boston, MA UNIVERSITY MEDICAL FACULTY DEPT OF PEDIATRIC AL- 720 Comparison Of Germfree and Conventional Mice For Evaluat- LERGY IMMUNOLOGY, ANTALYA, Turkey and Olcay Yegin, ing The Potential Allergenicity Of Dietary Proteins Using AKDENIZ UNIVERSITY MEDICAL FACULTY DEPT OF PEDI- Model Allergenic and Non-Allergenic Proteins ATRIC ALLERGY IMMUNOLOGY, Antalya, Turkey Nathan L. Marsteller 1,2 , Mr. Kwame Andoh-Kumi 1, Daniel A. Peter- 729 Risk Of Oral Food Challenges In Children - a Prospective Mul- son 3, Richard E. Goodman 1 and Joe L. Baumert 1, 1Food Allergy Re- ticenter Study - search and Resource Program, University of Nebraska-Lincoln, Dr. Toshiko Itazawa, MD, PhD 1, Dr. Motokazu Nakabayashi, MD, Lincoln, NE, 2School of Biological Sciences, University of Ne- PhD1, Dr. Yasunori Ito, MD, PhD 1, Dr. Yoshie Okabe, MD, PhD 1, braska-Lincoln, 3Johns Hopkins School of Medicine, Baltimore, MD Dr. Yoko S Adachi, MD, PhD 1, Dr. Yuichi Adachi, MD, PhD 1, Dr. 721 The Role Of Lipopolysaccharide In Skewing The Sensitization Komei Ito, MD, PhD 2 and Motohiro Ebisawa, MD, PhD, FAAAAI 3, Potential Of Purified b-Lactoglobulin In a Mouse Model 1Department of Pediatrics, University of Toyama, Toyama, Japan, Mr. Kwame Andoh-Kumi 1, Richard E. Goodman 1, Daniel A. Peter- 2Aichi Children’s Health and Medical Center, Obu, Aichi, Japan, son 2, Joe L. Baumert 1 and Nathan L. Marsteller 1,3 , 1Food Allergy Re- 3Clinical Research Center for Allergy and Rheumatology, Sagami- search and Resource Program, University of Nebraska-Lincoln, hara National Hospital, Kanagawa, Japan Lincoln, NE, 2Johns Hopkins School of Medicine, Baltimore, MD, 730 A Double-Blind Randomized Controlled Trial Of A Thickened 3School of Biological Sciences, University of Nebraska-Lincoln Amino-Acid-Based Formula In Children Allergic To Cow’s 722 Oral Co-Administration Of Peanut and Cholera Toxin Subunit Milk and To Protein Hydrolyzates B During Pregnancy and Lactation Blocks Anaphylaxis and In- Prof. Nicolas Kalach, MD, Ph D 1, Dr. Elena Bradatan 2, Prof. duces Epigenetic Modifications In Peanut Allergic Murine Alain Lachaux3, Dr. Francois Payot 3, Prof. Frederic de BLAY 4, Mothers Dr. Lydie Gu enard-Bilbault5,6, Dr. Riad Hatahet 7, Dr. Sandra Mu- Dr. Ying Song, MD 1, Dr. ChangDa Liu 1, Dr. Kamal D. Srivas- lier8 and Prof. Christophe Dupont, MD, PhD 9, 1Hopital^ Saint Vin- tava, PhD 1, Dr. Jia Chen, ScD 1,2, Dr. Rachel L. Miller, MD, cent de Paul, Groupement des Hospitaux de l’Institut Catholique de FAAAAI 3 and Dr. Xiu-Min Li, MD 1, 1Pediatrics, Icahn School Lille (GH-ICL), Lille, France, 2Department of Pediatrics, Regional of Medicine at Mount Sinai, New York, NY, 2Prevention, Icahn Hospital, Namur, Belgium, 3Gastroenterology, Hepatology and Nu- School of Medicine at Mount Sinai, NY, 3Division of Pulmonary, trition Unit, University and Pediatric Hospital of Lyon, France, Allergy and Critical Care Medicine, Columbia University, New 4CHRU Strasbourg, France, 5Regional University Hospital, Stras- York, NY bourg, Strasbourg, France, 6Allergologist, Illkirch-Graffenstaden, 723 Worsened Reaction Severity In Oral Food Challenges Confirms France, 7Pediatrician Allergologist, Forbach, France, 8Queen Fa- Need For In-Office Procedure biola Children’s, University Hospital, Brussels, Brussels, Belgium, 9

MONDAY Dr. Annie Esquivel , Dr. Girish V. Vitalpur, MD, FAAAAI, Dr. Hopital Necker Enfants Malades, Paris, France Kirsten Kloepfer, MD and Dr. Frederick E. Leickly, MD, MPH 731 Impact Of Formula Containing Docosahexaenoic Acid, Prebi- FAAAAI, Riley Hospital for Children at Indiana University Health, otics, and Beta-Glucan On Allergic Manifestations In Young Indianapolis, IN Children 724 Oral Food Challenge Outcome Among Children With a Nega- Dr. Deolinda Scalabrin, MD, PhD 1, Suzanne Stolz 1, Weihong tive Skin Prick Test Result Zhuang1, Mariana Pontes 2, Angela de Mattos 2, Indhira Almeida 2, Dr. Wipa Jessadapakorn, MD , Division of Allergy and Immunol- Carolina Godoy2, Sara Gatto 2, Vivian Leal 2, Gabriela Cabral 2, Ter- ogy, Department of Pediatrics, Faculty of Medicine, Prince of eza Ribeiro2 and Ribeiro2, 1Mead Johnson Nutrition, Evans- Songkla University, Hat-Yai, Songkhla, Thailand, Dr. Prapasri Ku- ville, IN, 2Federal University of Bahia, Brazil lalert, MD, Prince of Songkla University, Songkla, Thailand, Dr. 732 Parents’ Perception Of The Likelihood Of Future Life-Threat- Araya Yuenyongviwat, MD, Prince of Songkla University, ening Events In Their Children With Food Allergies Songkhla, Thailand and Dr. Pasuree Sangsupawanich, MD, Prince Dr. Peter Arkwright, MD, PhD, FAAAAI 1, Ms. Jennifer Ogg 1, Songkhlanagarind hospital, Hadyai, Thailand Dr. Naomi Davis 2 and Dr. Ming Wan 1, 1University of Manchester, 725 Abbreviated Oral Food Challenge As a Safe and Effective Alter- Manchester, United Kingdom, 2Royal Manchester Children’s Hos- native For Diagnosing Food Allergy In a Pediatric Clinic pital, United Kingdom April L. Goolsby, BS 1, Heather Minto, MD 1,2, Amy Perkins, MS 1,2 733 Can Training Improve Allergists’ Ability To Accurately Iden- and Kelly M. Maples, MD 1,2, 1Eastern Virginia Medical School, tify Anxiety In Children With Food Allergy? Norfolk, VA, 2Children’s Hospital of The King’s Daughters, Nor- Melissa Rubes1, Anna Podolsky 2, Nicole Caso 1, Rachel Annun- folk, VA ziato1, Dr. Amanda L. Cox, MD 2, Dr. Jennifer S. Kim, MD, 726 Safety Of Ungraded Oral Food Challenges In Ruling Out Pea- FAAAAI 2, Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI 2, Dr. Julie nut Allergy In Children Wang, MD, FAAAAI 2, Scott H. Sicherer, MD, FAAAAI 3 and Eyal Dr. Darlene Kassab Mansoor, MD, MS 1, Amit Singal, BS 2, Shemesh2, 1Fordham University, NY, 2Icahn School of Medicine at Shweta Bansil, BS 2 and Dr. Hemant P. Sharma, MD MHS Mount Sinai, NY, 3Mount Sinai School of Medicine, New York, NY FAAAAI 1, 1Children’s National Medical Center, 2George Washing- 734 Nutritional Status Impairment In Patients With Food Allergies ton University School of Medicine Dr. Gesmar Segundo , Mrs. Larissa Costa and Mrs. Erica Rezende, 727 Safety Of Oral Food Challenges To Extensively Heated Egg In Universidade Federal de Uberlandia, Uberlandia, Brazil Children 735 Everyday Life Impact On Food Allergy Spanish Children.Car- Dr. Cindy Nguyen, MD 1, Shweta Bansil, BS 2, Amit Singal, BS 2 egivers Perception and Dr. Hemant P. Sharma, MD MHS FAAAAI 3, 1Children’s Na- Dr. Elena Alonso-Lebrero, PhD , Hospital Materno Infantil Gre- tional Medical Center, Division of Allergy and Immunology, Wash- gorio Maran~on Pediatric Allergy Section, Madrid, Spain, Mr. Julio ington, DC, 2George Washington University School of Medicine, Monleon, MS, Santa Barbara, Madrid, Spain and Alberto Alvarez- 3Children’s National Medical Center, Division of Allergy and Im- Perea, MD, Hospital Materno Infantil Gregorio Maran~on, Pediatric munology, DC Allergy Department, Madrid, Spain 132 J ALLERGY CLIN IMMUNOL Abstracts AB343 VOLUME 133, NUMBER 2

736 The First 4 Central American Cases Of Delayed Meat Allergy 743 Variability In Measurement Of Allergen Skin Testing Results With Galactose-Alpha-1,3-Galactose Positivity Clustered Among Allergy-Immunology Specialists Among Field Biologists In Panama Dr. Tiffany Jean 1, Dr. Kenny Y. Kwong 1 and Dr. Nasser Redjal, Dr. Paige G. Wickner, MD , Brigham and Women’s Hospital, Di- MD, FAAAAI 2, 1Harbor-UCLA Medical Center, 2Harbor-UCLA vision of Rheumatology, Immunology and Allergy, Chesnut Hill, Medical Center, Torrance, CA MA and Scott P. Commins, MD, PhD, University of Virginia Health 744 Serologic Specific IgE (sIgE) Testing In a Closed Healthcare System, Charlottesville, VA System 737 Incidence Of New Onset Food Allergy In Renal, Cardiac, and Dr. Daniel A. Steigelman, MD and Dr. Tonya S. Rans, MD, Wil- Hepatic Transplant Recipients and Correlation With Immuno- ford Hall Ambulatory Surgical Center, Joint Base San Antonio - suppression Protocol Lackland AFB, TX Franc¸ois Graham, MD, MSc1, Fr ed eric Racicot2, Luminita Iuli- 745 Outcomes After Implementation Of An Inpatient Antibiotic ana Jamali, MD 2, Marie-Jeanne Lebel, MD 2, Hugo Chapdelaine, Prescribing Pathway For Patients With Penicillin Or Cephalo- MD 2, Fernando Alvarez, MD 2, V eronique Phan Cong, MD 2, sporin Allergy Marie-Josee Raboisson, MD 2, Louis P. Paradis, MD FRCPC Dr. Kimberly Blumenthal, MD , Allergy and Immunology, Divi- FAAAAI 2 and Anne M. Des Roches, MD FRCPC FAAAAI 2, sion of Rheumatology, Allergy, and Immunology, Department of 1CHUM, Hopital^ Notre-Dame, Montreal, QC, Canada, 2Centre Medicine, Massachusetts General Hospital, Harvard Medical Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada School, Boston, MA, Dr. Erica Shenoy, MD, PhD, Division of In- 738 Late and Secondary Onset Food Allergy fectious Disease and Infection Control Unit, Department of Medi- Dr. Liat Nachshon, MD 1, Dr. Michael Goldberg, MD, PhD 1, Dr. cine, Massachusetts General Hospital, Harvard Medical School, Arnon Elizur, MD 1,2, Dr. Michael B. Levy, MD, FAAAAI 1 and Boston, MA, Ms. Christy Varughese, Pharm.D., Department of Prof. Yitzhak Katz, MD, FAAAAI 1,2, 1Assaf Harofeh, Zerifin, Is- Pharmacy, Infection Control Unit, Massachusetts General Hospital, rael, 2Tel Aviv University, Tel Aviv, Israel Boston, MA, Dr. David Hooper, MD, PhD, Division of Infectious 739 Food Allergy Testing Practices Of Primary Care Pediatricians Disease and Infection Control Unit, Department of Medicine, Mas- In Illinois sachusetts General Hospital, Boston, MA and Dr. Aleena Banerji, Hector Rodriguez, MD 1,2, Ms. Claudia Lau 1, Dr. Ruchi Gupta, MD, Division of Rheumatology, Allergy, and Immunology, Depart- MD, MPH1,2 and Melanie M. Makhija, MD 1,3, 1Ann and Robert ment of Medicine, Massachusetts General Hospital, Harvard Med- H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Northwest- ical School, Boston, MA ern University Feinberg School of Medicine, Chicago, IL, 3Division 746 The Effect Of Panel Ordering On Utilization Of In Vitro Spe- of Allergy & Immunology, Department of Pediatrics,Northwestern cific IgE Testing By Primary Care Physicians In a Large HMO University Feinberg School of Medicine, Chicago, IL Dr. Bruce J. Goldberg, MD, PhD, FAAAAI , Kaiser Permanente, 740 Understanding The Role Of Online Resources For Childhood Los Angeles, CA and Dr. John S. Kaptein, PhD, Southern Califor- Food Allergies nia Permanente Medical Group, Los Angeles, CA David Goese , University of Chicago Pritzker School of Medicine, 747 Premature Discontinuation Of Allergy Immunotherapy-Inade- Chicago, IL and Ves Dimov, MD, University of Chicago Medicine, quate Reimbursement By Health Insurers A Major Factor Chicago, IL; Section of Allergy, Asthma and Immunology, Depart- Dr. Surender K. Vaswani, MD, FAAAAI , Allergy & Asthma ment of Pediatrics, Department of Medicine, University of Chicago, Clinical Center, Columbia, MD, Ravi Vaswani, New York Univer- Chicago, IL sity School of Medicine, Dr. Njideka Udochi, Howard County Gen- 741 Clinical Features, Diagnosis, Management and Natural History eral Hospital/Johns Hopkins, Rajiv Karani, University of Cincinnati Of Food Protein-Induced Enterocolitis Syndrome In a National School of Medicine and Dr. Leena Parikh, St.Agnes Hospital Cohort 748 Adherence To Labeling Guidelines Of Inhalant Allergen Immu- Dr. Todd David Green, MD, FAAAAI 1, Dr. Matthew J. Green- notherapy Practice Parameter 2011 At The University Of Mich- hawt, MD, MBA, MSc 2, Dr. Tammy S. Jacobs, MD, MA 1 and Fal- igan Health Service lon Schultz3, 1Children’s Hospital of Pittsburgh of UPMC, Dr. Marilyn Karam, MD 1, Kiela Samuels 2, Cynthia Hernandez, Pittsburgh, PA, 2Department of Internal Medicine, The University RN 2, Dr. Christine L. Holland, MD 1 and Dr. Matthew J. Greenhawt, of Michigan Medical School, Division of Allergy and Clinical Im- MD, MBA, MSc 3, 1The University of Michigan, Division of Al- munology, Ann Arbor, MI, 3International Association for Food Pro- lergy and Clinical Immunology, Ann Arbor, MI, 2University of tein Enterocolitis (IAFFPE) Michigan Health System, Ann Arbor, MI, 3Department of Internal Medicine, The University of Michigan Medical School, Division of MONDAY Allergy and Clinical Immunology, Ann Arbor, MI 749 The Prevalence Of Allergic Rhinitis Among High- School Male Military Recruits In Jordan Dr. Mansour Fuad Karadsheh, MD and Dr. Suleiman Soudi, Health Care Delivery Royal Medical Services, Madaba, Jordan 750 Allergen Sensitivity Patterns Among Atopic Individuals At A 4209 Tertiary Allergy Center Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Dr. Lukena U. Karkhanis, MD , Dr. Sarena Sawlani, MD and Dr. 742 Health Literacy Is Associated With Medication Adherence In Andrew Kau, MD, PhD, Washington University School of Medi- Adolescents and Young Adults With HIV-1 Infection cine, St. Louis, MO Dr. Amrita Khokhar, MD , Department of Medicine, Hofstra North 751 Assessing Quality Of Life In Patients With AERD After Aspirin Shore-LIJ School of Medicine, Dr. Robert Sporter, MD, Division of Desensitization Allergy/Immunology, Departments of Medicine and Pediatrics, Dr. Melissa Iammatteo, MD 1, Dr. Autumn Chandler Guyer, MD 2, Hofstra North Shore-LIJ School of Medicine, Kathryn Kilkenny, Dr. Rebecca Saff, MD, PhD 3, Dr. Eric Holbrook, MD 4, Dr. Stacey Division of Allergy/Immunology, Departments of Medicine and Pe- Gray, MD 4, Dr. Aidan Long, MD, FAAAAI 5 and Dr. Aleena Bane- diatrics, Hofstra North Shore-LIJ School of Medicine and Dr. David rji, MD 5, 1Massachusetts General Hospital, Boston, MA, 2Massa- Rosenthal, DO, Division of Allergy/Immunology, Departments of chusetts General Hospital, Harvard Medical School, Boston, MA, Medicine and Pediatrics, Hofstra North Shore-LIJ School of Med- 3Allergy and Clinical Immunology, Massachusetts General Hospi- icine, Great Neck, NY tal, Boston, MA, 4Massachusetts Eye and Ear Infirmary, Boston,

133 AB344 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

MA, 5Division of Rheumatology, Allergy, and Immunology, De- AZ, Dr. David W. Hauswirth, MD, FAAAAI, Nationwide Chil- partment of Medicine, Massachusetts General Hospital, Harvard dren’s Hospital, Columbus, OH, Dr. Christopher W. Calabria, Medical School, Boston, MA MD, Dilley Allergy and Asthma Specialists, San Antonio, TX, 752 Published Findings On Dust Allergens May Be Inaccurate Due Dr. Lawrence D. Sher, MD, FAAAAI, Peninsula Research Associ- To Improper Handling Of Values Below The Lower Limit Of ates, Rolling Hills Estates, CA and Dr. D esiree E.S. Larenas Linne- Detection mann, MD, FAAAAI, Hospital Medica Sur, Mexico D.F., Mexico Henry Lynn , Mr. Agustin Calatroni, MA MS, Katy Jaffee, MS, Re- 760 Venom Immunotherapy Use With Contraindicated Medication: becca A. Zabel and Samuel J. Arbes Jr., Rho, Inc., Chapel Hill, NC A Survey Of AAAAI Member’s Experience 753 Patient-Reported Factors That Influence Diphenhydramine Use Dr. David W. Hauswirth, MD, FAAAAI , Buckeye Allergy, Co- In Children and Adults In An Allergy Specialty Practice lumbus, OH; Nationwide Children’s Hospital, Columbus, OH, Dr. Dr. Prakash Navaratnam 1, Dr. Robert Anolik, MD, FAAAAI 2, Dr. Matthew A. Rank, MD, FAAAAI, Mayo Clinic, Scottsdale, AZ, Howard Friedman, MS, PhD 1 and Dr. Eduardo Urdaneta, MD 3, Dr. D esiree E.S. Larenas Linnemann, MD, FAAAAI, Hospital 1DataMed Solutions LLC, New York, NY, 2Allergy and Asthma Medica Sur, Mexico D.F., Mexico, Dr. Lawrence D. Sher, MD, Specialists, PC, Blue Bell, PA, 3McNeil Consumer Healthcare, FAAAAI, Peninsula Research Associates, Rolling Hills Estates, Fort Washington, PA CA and Dr. Christopher W. Calabria, MD, Dilley Allergy and Asthma Specialists, San Antonio, TX 761 Simultaneous Measurement Of Multiple Proteins In Blattella Germanica Extract Using Antibody-Based Multiplex Assay Dr. Taruna Khurana, PhD 1, Ms. Maggie Collison 1 and Dr. Jay E. Allergen Extracts and Immunotherapy Slater, MD 2, 1CBER FDA, 2FDA/CBER/OVRR/DBPAP, Rockville, MD 4210 762 Characterization and Protein Composition Of Food Allergen Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Extracts 754 The Efficacy and Safety Of The Short Ragweed Sublingual Im- Dr. Greg A. Plunkett, PhD and Dr. Tricia Moore, PhD, ALK- munotherapy Tablet MK-3641 Is Similar In Asthmatic and Abello, Inc, Round Rock, TX Nonasthmatic Subjects Treated For Allergic Rhinitis With/ 763 Stability and Compatibility Of Cat, Dog, Dust Mite, and Cock- Without Conjunctivitis (AR/C) roach Extracts In Indoor Allergen Mixtures and Dilutions For Dr. Jennifer Maloney, MD 1, Dr. David I. Bernstein, MD, FAAAAI 2, Immunotherapy Dr. Jacques H ebert, MD 3, Dr. Martha White, MD 4, Dr. Robert Fisher, Dr. Silvia Huebner, MD 1, Dr. Satyen Manilal Gada, MD 2, Dawn MD 5, Dr. Thomas B. Casale, MD, FAAAAI 6, Dr. Amarjot Kaur, Hall, BS 3 and Dr. Thomas Grier, MD 3, 1Evans Army Community PhD1 and Dr. Hendrik Nolte, MD, PhD 1, 1Merck, Whitehouse Sta- Hospital, Fort Carson, CO, 2Walter Reed National Military Medical tion, NJ, 2Bernstein Allergy Group, Cincinnati, OH, 3Centre de Re- Center, Bethesda, MD, 3Greer Labs cherche Appliquee en Allergie de Qu ebec, Qu ebec City, QC, 764 Interest Of Mass Spectrometry-Based Quantification Of Rele- Canada, 4Institute for Asthma & Allergy, Wheaton, MD, 5Allergy vant Allergens To Improve The Standardization Of Allergen 6

MONDAY Research & Care, Milwaukee, WI, Univeristy Of South Florida Extracts Morsani College Of Medicine, Tampa, FL Thierry Batard, PhD1, Emmanuel Nony 2, Christel Dayang, PhD 2, 755 Compliance With Guidelines In The Use Of Allergen Immuno- Julien Bouley, PhD 2, Maxime Le Mignon, PhD 2, Christelle Ber- therapy rouet2, Aur elie Lautrette, PhD2, Marie Naveau, PhD 2, Henri Cha- Dr. Pudupakkam K Vedanthan, MD 1, Ms. Christina Cutter, MSc, bre, PhD2 and Dr. Philippe Moingeon, PhD 3, 1Stallergenes, BA 2, Ms. Phuong Dinh, BS 2 and Mr. Peter DeWitt, MS 2, 1Univer- Antony, France, 2Stallergenes, France, 3Stallergenes SA, Antony, sity of Colorado, Lakewood, CO, 2University of Colorado - An- France schutz Medical Campus, Aurora, CO 756 Efficacy Of Short Ragweed Sublingual Immunotherapy Tablet (SLIT-T) In Mono-Sensitized and Poly-Sensitized Subjects Dr. David I. Bernstein, MD, FAAAAI 1, Kevin R. Murphy, MD 2, Outcome Measures and Challenge Testing with Dr. Hendrik Nolte, MD, PhD 3, Dr. Amarjot Kaur, PhD 3 and Dr. Jen- nifer Maloney, MD 3, 1Bernstein Allergy Group, Cincinnati, OH, Immunotherapy 2Boys Town National Research Hospital, Boys Town, NE, 3Merck, Whitehouse Station, NJ 4211 757 Trends In Prescribing Of Specific Immunotherapy For Grass Monday, March 3rd, 2014, 9:45 AM - 10:45 AM Pollen Allergy In Germany: 2005-2012 765 Baseline Predictors Of Symptom Severity Following Exposure Prof. Ulrich Wahn, Prof Dr Med 1, Amanda McDonnell 2, Catrina To House Dust Mite In An Antigen Challenge Chamber (ACC) Richards2, Dr. Felicia C. Allen-Ramey, PhD 3, Mr. Jakob N. Andrea- Daniel Ramirez, MD 1, Robert L. Jacobs, MD 1, Cynthia Rather, sen4, Charles Hawes 2 and Dirk Demuth2, 1Charite, Berlin, Ger- CCRC1, Andrew Carrillo, BS 2,3, Weijing He, MD 2,3, Nathan many, 2IMSHealth, United Kingdom, 3Merck & Co, Inc, West Harper, BS 2,3, Charles Andrews, MD 1 and Sunil K. Ahuja, Point, PA, 4ALK, Denmark MD 2,3, 1Biogenics Research Chamber, San Antonio, TX, 2Depart- 758 Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In The ment of Medicine, University of Texas Health Science Center, Treatment Of Rhinitis Symptoms In Patients With Grass Pol- San Antonio, TX, 3Veterans Administration Center for Personalized len-Induced Allergic Rhinoconjunctivitis Medicine, South Texas Veterans Health Care System, San Antonio, Prof. Claus Bachert, MD, PhD 1, Prof. Alain Didier, MD, PhD 2, TX Ms. Laurence Ambroisine, Msc3, Dr. Kathy Abiteboul, PharmD 3 766 Validation Of Biogenics Research Chamber For Elicitation Of and Dr. Robert K. Zeldin, MD 3, 1Universitair Ziekenhuis Gent, Symptoms To Dust Mite Antigen (Der p1) Ghent, Belgium, 2Larrey Hospital, CHU, Toulouse, France, 3Stal- Robert L. Jacobs, MD 1, Cynthia Rather, CCRC 1, Fabio Jimenez, lergenes S.A., Antony, France BS 2,3, Hernan Martinez, MD 2,3, Weijing He, MD 2,3, Daniel Ram- 759 Allergen Immunotherapy Safety While Using ‘‘High Risk’’ irez, MD 1, Charles Andrews, MD 1 and Sunil K. Ahuja, MD 2,3, 1Bi- Medication: A Survey Of AAAAI Members ogenics Research Chamber, San Antonio, TX, 2Department of Dr. Matthew A. Rank, MD, FAAAAI , Mayo Clinic, Scottsdale, Medicine, University of Texas Health Science Center, San Antonio,

134 J ALLERGY CLIN IMMUNOL Abstracts AB345 VOLUME 133, NUMBER 2

TX, 3Veterans Administration Center for Personalized Medicine, Tcheurekdjian, MD, FAAAAI 4, 1University Hospitals, South Eu- South Texas Veterans Health Care System, San Antonio, TX clid, OH, 2Rainbow Babies and Children’s Hospital, Cleveland, 767 Magnitude Of Changes In Patient Symptom and Medication OH, 3Case Western Reserve University School of Medicine, Scores In Grass Allergy Immunotherapy Trials: Dependency Cleveland, OH, 4Allergy/Immunology Associates, Inc., South Eu- On Levels Of Pollen Exposure clid, OH Dr. Hendrik Nolte, MD, PhD 1, Prof. Stephen R. Durham, MA MD FRCP 2, Dr. Harold S. Nelson, MD, FAAAAI 3, Dr. David I. Bernstein, MD, FAAAAI 4, Dr. Peter S. Creticos, MD, FAAAAI 5, Dr. Ziliang Li, PhD 1 and Dr. Jens Andersen, PhD 6, Mechanistic Insight into Pollens and Other 1Merck, Whitehouse Station, NJ, 2Imperial College London, Lon- don, United Kingdom, 3National Jewish Health, Denver, CO, Antigens 4Bernstein Allergy Group, Cincinnati, OH, 5Johns Hopkins Divi- sion of Allergy & Clinical Immunology, 6ALK-Abello, 4212 Hørsholm, Denmark Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 768 Evaluation Of In Histamine Nasal Provo- 775 Protease Inhibitor Reduces Airway Response and Inflammation cation Test In Children and Adolescents In Mouse Model Of Cockroach Allergy Dr. Fausto Y. Matsumoto , Federal University of S ~ao Paulo, S ~ao Mr. Sanjay Saw, M.Sc. and Dr. Naveen Arora, Ph.D, CSIR Insti- Paulo, Brazil, Dr. Gustavo Wandalsen, MD, UNIFESP, Sao Paulo, tute of Genomics and Integrative Biology, New Delhi, India Brazil, Dr. Aline Mendes, Federal University of S ~ao Paulo, Brazil. 776 Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Al- and Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, lergen Induced TGF Beta 1 Secretion In Fibroblasts Sao Paulo, Brazil Sarah Mirza1,2, Yufeng Zhou, MD, PhD 1, Priya Tripathi, PhD 1, 769 EQ-5D Health Utility Values In The Treatment Of Seasonal Liang Yuan 1, Beverly Plunkett, MS 1, Allen Myers, Ph.D 1 and Pei- Grass Pollen Induced Rhinoconjunctivitis song Gao, MD, PhD1, 1Division of Allergy & Clinical Immunology, Mr. Jakob N. Andreasen 1, Dr. Chris Poole 2, Dr. Christian Bannis- Johns Hopkins University School of Medicine, Baltimore, MD, ter3, Dr. Jens Andersen, PhD 4 and Mr. Niels Serup-Hansen 1, 1ALK, 2Sher-I-Kashmir Institute of Medical Sciences, Jammu and Kash- Denmark, 2Cardiff University, Cardiff, Wales, 3Cardiff University, mir, India 4ALK-Abello, Hørsholm, Denmark 777 Effect Of Peanut Allergens On Intestinal Barrier Permeability 770 Ex-Vivo Allergen Stimulation In Whole Blood: A Novel Ap- and Tight Junction Localisation In Caco-2 Cell Cultures proach For Evaluating Mechanisms Of Action Of Synthetic Prof. Cenk Suphioglu, PhD 1, Ms. Dwan Price, BSc Hons 1, Prof. Peptide Immuno-Regulatory Epitopes Leigh Ackland, PhD2, A. Wesley Burks, MD, FAAAAI 3 and Dr. Dr. Pascal LC Hickey, BPharm PhD 1, Dr. Mark Larch e, PhD 2, Dr. Matthew Knight, PhD 4, 1Deakin University, Australia, 2Deakin Rod Hafner, PhD 3, Ms. Kristen Armstrong, M.Sc. 4, Ms. Eileen Lee, Universisty, Australia, 3University of North Carolina, Chapel Hill, BA (Hons) 5, Dr. Elaine Lee, PhD 5 and Dr. Stephen A. Kilfeather, NC, 4Department of Primary Industries, Australia PhD5, 1Adiga Life Sciences, Hamilton, Canada, 2McMaster Univer- 778 Synergistic Effect Of Dermatophagoides Pteronyssinus Aller- sity, Hamilton, ON, Canada, 3Circassia Ltd, Oxford, United King- gens and Dexamethasone On Expression Of CD163 By Periph- dom, 4Adiga Life Sciences Inc., Hamilton, ON, Canada, 5Aeirtec eral Blood Mononuclear Cells Of Allergic Asthma Patients Limited, Newcastle upon Tyne, United Kingdom Prof. Krzysztof Kowal, MD, PhD 1, Pawel Bernatowicz, MD, 771 Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In Grass PhD2, Prof. Lech Chyczewski, MD, PhD 2 and Prof. Anna Bod- Pollen-Induced Allergic Rhinoconjunctivitis: Pooled Analysis zenta-Lukaszyk, MD, PhD 3, 1Medical University of Bialystok, Bia- By Age lystok, Poland, 2Medical University of Bialystok, 3Medical Dr. Robert K. Zeldin, MD 1, Prof. Ulrich Wahn, Prof Dr Med 2, University of Bialystok, Poland Prof. Alain Didier, MD, PhD 3, Mrs. Armelle Montagut 1 and Dr. 779 IgE Antibodies and Fc eRI Are Critical For Acquired Resistance Marie-Pierre Furrer, PhD 1, 1Stallergenes S.A., Antony, France, Against Honeybee Venom In Mice 2Charite, Berlin, Germany, 3Larrey Hospital, CHU, Toulouse, Dr. Philipp Starkl, PhD 1, Dr. Thomas Marichal, DVM PhD 1, Dr. France Laurent L. Reber, PhD 1, Dr. Janet Kalesnikoff, PhD 1, Dr. Hans C. 772 Characterization Of Allergic Rhinitis Symptomotology Induced Oettgen, MD, PhD, FAAAAI 2, Dr. Martin Metz, MD, PhD 3 and By a Nasal Allergen Challenge (NAC) Titration In a Dust Mite Dr. Stephen J. Galli, MD 1, 1Stanford University School of Medi- Sensitize Population cine, Stanford, CA, 2Boston Children’s Hospital, Boston, MA, MONDAY Mr. Paul Gomes 1, Endri Angjeli 2, Mr. Keith Lane 2 and Dr. Paul H. 3Charite Campus Mitte, Berlin, Germany Ratner, MD, FAAAAI 3, 1ORA. Inc, Andover, MA, 2Ora, Inc, And- 780 Ragweed Pollen Proteins Bind TLR4/MD2, and Rapidly Re- over, MA, 3Sylvana Research, San Antonio, TX cruit MyD88 and TRAF6 To The Signaling Complex 773 Atopic and Non-Atopic Individuals Manifest Partly Concordant Dr. Qian Sun, PhD , Dr. Koa Hosoki, MD, PhD, Dr. Leopoldo Clinical and Leukocyte Responses Following Exposure To Aguilera-Aguirre, PhD, Prof. Istvan Boldogh, PhD and Prof. Sanjiv House Dust Mite In An Antigen Challenge Chamber (ACC) Sur, MD, University of Texas Medical Branch, Galveston, TX Weijing He, MD 1,2, Nathan Harper, BS 1,2, Andrew Carrillo, 781 Sensitization To Silkworm Moth (Bombyx mori) Allergen In BS 1,2, Charles Andrews, MD 3, Cynthia Rather, CCRC 3, Daniel Patients With Respiratory Allergy Ramirez, MD 3, Robert L. Jacobs, MD 3 and Sunil K. Ahuja, Mrs. Laura ML Araujo , Federal University of Parana, Brazil and MD 1,2, 1Department of Medicine, University of Texas Health Sci- Prof. Nelson A. Rosario, MD, PhD, FAAAAI, Federal University of ence Center, San Antonio, TX, 2Veterans Administration Center Parana, Curitiba, Brazil for Personalized Medicine, South Texas Veterans Health Care Sys- 782 Balsam Of Peru, a Common Contact Dermatitis Allergen, Is a tem, San Antonio, TX, 3Biogenics Research Chamber, San Anto- CD1a Antigen nio, TX Sarah Nicolai, MD 1,2, Tan-Yun Cheng, PhD 1,2, Elvire A. Bour- 774 The Effects Of Pollen Season On Reactions To Subcutaneous geois, PhD1,2, Annemieke de Jong, PhD 3 and D. Branch Moody, Immunotherapy MD 1,2, 1Brigham and Women’s Hospital, Division of Rheumatol- Dr. Devi Jhaveri, DO 1, Dr. Julie Abraham, M.D. 2, Megan Betteley, ogy, Immunology and Allergy, Boston, MA, 2Harvard Medical B.S.3, Dr. Mary Ann O’Riordan, PhD 2, Dr. Theodore H. Sher, MD, School, Boston, MA, 3Columbia University Medical Center, De- FAAAAI 4, Dr. Robert W. Hostoffer, DO 4 and Dr. Haig partment of Dermatology, New York, NY

135 AB346 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

783 Cellular Infiltrate Induced By Bites From The Tick Ambly- Andrew M. Smith, MD, FAAAAI 8, Dr. Peter Lenz 9 and Dr. Tolly omma Americanum In Subjects With Or Without IgE To Ga- Epstein, MD, MS 10 , 1University of Cincinnati Medical Center, Cin- lactose-Alpha-1,3-Galactose (Alpha-gal) cinnati, OH, 2Bernstein Allergy Group, Cincinnati, OH, 3Bernstein Dr. Nikhila Schroeder, MD 1, Mr. Jake Eccles 2, Erin J. Klaffky, Clinical Research Center, LLC, Cincinnati, OH, 4Cincinnati Chil- MD, PhD1 and Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 1, dren’s Hospital Medical Center, Cincinnati, OH, 5Division of Im- 1Division of Asthma, Allergy & Immunology, University of Vir- munology Allergy & Rheumatology, University of Cincinnati ginia Health System, 2University of Virginia School of Medicine Medical Center, Cincinnati, OH, 6University of Cincinnati, 7Uni- 784 Duox2 and Mitochondria-Induced Antiviral Innate Immune versity of Cincinnati, Cincinnati, OH, 83255 Eden Ave., HPB Response After Influenza A Virus Infection In Human Nasal 350, University of Cincinnati Medical Center, Cincinnati, OH, Epithelium 9The University of Cincinnati Medical Center, 10 Allergy Partners Prof. Hyun Jik Kim 1,2, Prof. Chang-Hoon Kim 3,4, Dr. Sung-Shik of Central Indiana, Indianapolis, IN Kim5 and Prof. Joo-Heon Yoon 3,6, 1Chung-Ang University College 791 Texting Medication Reminders For Better Asthma Control In of Medicine, Seoul, South Korea, 2Airway Mucus Institute, Seoul, Children and Teens South Korea, 3Department of Otorhinolaryngology, Yonsei Univer- Dr. Humaa M. Bhatti, DO 1, Ms. Wafa Alame, RN 1, Mr. Joseph sity College of Medicine, Seoul, South Korea, 4The Airway Mucus Adams2, Dr. Jenny M. Montejo, MD 1, Dr. Milind V. Pansare, Institute, Yonsei University College of Medicine, Seoul, South Ko- MD, FAAAAI 1, Dr. Pavadee Poowuttikul, MD 1 and Dr. Elizabeth rea, 5Koenko Nose Infirmary, Seongnam, South Korea, 6Research A. Secord, MD, FAAAAI 2, 1Children’s Hospital of Michigan, De- Center for Human Natural Defense System, Yonsei University Col- troit, MI, 2Wayne State University, Detroit, MI lege of Medicine, Seoul, South Korea 792 Adherence To Prescribed Controller Therapy and Effects On 785 Persistent Endothelial Damage After Intravenous Immunoglob- Asthma Control In The Hispanic Population Of a Pediatric Dis- ulin Therapy In Kawasaki Disease ease Management Program Dr. Yoshihiko Sakurai 1,2 , Dr. Hideo Takatsuka 1, Dr. Mutsuzo Ta- Dr. Lyne G. Scott, MD 1, Tricia Morphew 2, Marilyn Li 1 and Dr. kada 1 and Dr. Masato Nishino 1, 1Nara Prefectural Mimuro Hospital, Salima A. Thobani, MD 1, 1University of Southern California, Sango, Japan, 2Matsubara Tokushukai Hospital, Matsubara, Japan 2Morphew Consulting, LLC, CA 786 Prevalence Of Toxocariasis In General Population Based On 793 Correlation Between Emergency Department Visits For Serologic Test Asthma Exacerbation and No Show Visits To Primary Care Prof. Byung-Jae Lee, MD 1, Dr. Jin-Young Lee, MD 1, Dr. Mi-Jung Provider In a Pediatric Population Oh, MD 2 and Prof. Dong-Chull Choi, MD 1, 1Samsung Medical Dr. Margaret Redmond, M.D. and David R. Stukus, MD, Center, 2Bundang Jesaeng General Hospital FAAAAI, Nationwide Children’s Hospital, Columbus, OH 787 Vitamin D Levels and Sensitization To Indoor Inhalant Aller- 794 Choosing Wisely: Adherence By Allergists To Recommended gens In Korea Use Of Spirometry In The Diagnosis and Management Of Adult Dr. Kyung-Hwan Lim 1,2, Dr. Min-Gyu Kang 1,2, Dr. Han-Ki Park 1, Asthma Prof. So-Hee Lee1, Prof. Min-Suk Yang 1,3, Prof. Woo-Jung Song, Dr. Kristin C. Sokol, MD, MPH , Dr. Gregg Wilkinson, PhD, Ms. M.D.1, Prof. Hye-Ryun Kang 1, Prof. Heung-Woo Park, MD, Karen Pierson, MA and Dr. Randall M. Goldblum, MD, University 1 1 1,2

MONDAY PhD , Prof. Sun-Sin Kim , Prof. Yoon-Seok Chang , Prof. Sang of Texas Medical Branch, Galveston, TX Heon Cho, MD, PhD1, Prof. Kyung-Up Min, MD, PhD 1 and Prof. Sae-Hoon Kim1,2, 1Department of Internal Medicine, Seoul Na- tional University College of Medicine, Seoul, South Korea, 2De- partment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, 3SMG-SNU Boramae Bone Marrow Transplantation in Primary Medical Center, Seoul, South Korea 788 Measuring Vascular Leak During Respiratory Viral Infections Immunodeficiencies Dr.Brian T. Kelly, MD , Mrs. Desire Hunter and Dr. Mitchell H. Gray- son, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI 4602 789 Effects Of Rhinovirus (RV) 39 Infection On Airway Hyper-Re- Monday, March 3rd, 2014, 2:00 PM - 3:15 PM activity (AHR) To Histamine and Carbachol In Human Airways 795 G Protein-Coupled Receptor Kinase-3 (GRK-3) In Bone Mar- Joshua L. Kennedy, MD 1, Stacie M. Jones, MD 1,2, Ms. Megan row Niche Interactions and Transplantation Kurten1,3, Ms. Suzanne House 1,3 and Richard Kurten, PhD 1,3, 1Ar- Jaime M. Brozowski 1,2, Roman Timoshchenko 2, Jessica Koontz 3, kansas Children’s Hospital Research Institute, Little Rock, AR, Janet Rubin3,4, Matthew Billard 2 and Teresa K. Tarrant 2,3, 1Depart- 2University of Arkansas for Medical Sciences and Arkansas Chil- ment of Microbiology and Immunology, University of North Caro- dren’s Hospital, Little Rock, AR, 3University of Arkansas for Med- lina School of Medicine, Chapel Hill, NC 27599, USA, 2Thurston ical Sciences, Little Rock, AR Arthritis Research Center and Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA, 3School of Medicine, Uni- versity of North Carolina, Chapel Hill, NC 27599, USA, 4Pediatrics and Pharmacology and Department of Medicine, Division of Endo- Adherence crinology and Metabolism, University of North Carolina, Chapel Hill, NC 27599, USA 4601 796 Allogeneic Hematopoietic Stem Cell Transplantation For Im- Monday, March 3rd, 2014, 2:00 PM - 3:15 PM mune Dysregulation, Polyendocrinopathy, X-Linked (IPEX) 790 Poor Asthma Control In Older Adults Is Associated With Re- Syndrome Resolves Enteropathy and Autoimmunity: A Single duced Adherence To Controller Therapies and Inability To Af- Institution Experience ford Medications Dr. Zeynep Yesim Yesim Kucuk, MD , Dr. Jack J.H. Bleesing, Dr. Jessica Tan, MD, MPH 1, Dr. David I. Bernstein, MD, MD, PhD, Dr. Rebecca A. Marsh, MD, Dr. Kejian Zhang, MD, FAAAAI 2, Ms. Cheryl Koff Bernstein, RN BSN CCRC 3, Dr. Pat- Dr. Stella Davies, MBBS, PhD and Dr. Alexandra H. Filipovich, rick Ryan, PhD4, Dr. Jonathan A. Bernstein, MD, FAAAAI 5, Ms. MD, Cincinnati Children’s Hospital Medical Center, Banu Kesavalu 6, Dr. Manuel S. Villareal, MD, FAAAAI 1,7, Dr. Cincinnati, OH

136 J ALLERGY CLIN IMMUNOL Abstracts AB347 VOLUME 133, NUMBER 2

797 Natural Killer Cell Immunoglobulin Like Receptor (KIR) Ge- FAAAAI 3, 1Department of Pediatric Allergy and Immunology, netic Profile Is a Strong Predictor Of Allogeneic Hematopoietic Stanford University, Stanford, CA, 2Division of Laboratory Sci- Cell Transplant Outcomes ences, National Center for Environmental Health, Centers for Dis- Dr. Rehan M. Faridi, PhD 1, Taylor Kemp 1, Dr. Poonam Dhar- ease Control and Prevention, Atlanta, GA, 3Pediatric Allergy mani, PhD1, Dr. Victor Lewis, MD 2, Dr. Noureddine Berka, Immunology, Stanford University, Stanford, CA PhD3, Dr. Jan Storek, MD, PhD 1 and Dr. Faisal Khan, PhD 1, 1Uni- 802 Impact Of BMI On Ozone-Induced IL-1 b In The Airways Of versity of Calgary, Calgary, AB, Canada, 2Alberta Children’s Hos- Human Volunteers pital, Calgary, AB, Canada, 3Calgary Laboratory Services, Calgary, Dr. Michelle L. Hernandez, MD 1, Dr. Krista Todoric, MD 1, Ms. AB, Canada Katherine Mills, BA 2, Dr. Haibo Zhou, PhD 3 and Dr. David B. Pe- 798 Transient Lymphopenia Of Infancy: A Previously Unrecognized den, MD, MS, FAAAAI 4, 1University of North Carolina at Chapel Entity Hill School of Medicine, Chapel Hill, NC, 2University of North Dr. Robert Sporter, MD , Division of Allergy/Immunology, De- Carolina Chapel Hill School of Medicine, Chapel Hill, NC, 3Uni- partments of Medicine and Pediatrics, Hofstra North Shore-LIJ versity of North Carolina at Chapel Hill, School of Public Health, School of Medicine, Dr. Catherine Capo, MD, Department of Med- 4Office #544, Campus Box 7310, University of North Carolina at icine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY Chapel Hill School Medicine, NC and Dr. Vincent R. Bonagura, MD, FAAAAI, Division of Allergy/ 803 Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced Immunology, Departments of Medicine and Pediatrics, Hofstra Airway Inflammation and Hyperresponsiveness (AHR) North Shore-LIJ School of Medicine, Great Neck, NY Dr. Qi Yang, PhD , Moyar Q. Ge, Blerina Kokalari, Imre G Redai, Xinxin Wang, Dr. Avinash Bhandoola, MBBS PhD and Dr. Angela Haczku, MD, PhD, FAAAAI, University of Pennsylvania, Philadel- phia, PA Air Pollution/Allergens/Air Quality

4603 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM Food Allergy 799 Associations Among Volatile Organic Compounds, Allergic Sen- sitization, and Respiratory Illness In Children With Asthma 4604 Enrolled In a Study Of Low-Income, Green Eco-Friendly Hous- Monday, March 3rd, 2014, 2:00 PM - 3:15 PM ing (The Green Housing Study) 804 Peanut T Cell Epitope Discovery: Ara h1 and Ara h3 Dr. Joy Hsu, MD, MSCI 1, Sandra Chaves, MD, MSc 2, Marika Dr. Manish Ramesh, MD, PhD 1, Madhan Masilamani, PhD 2, Dr. Iwane, PhD, MPH2, Yang Qiu, ScM 3, Christopher Schaffer, BS 4, George N. Konstantinou, MD, PhD, MSc 3,4, Jay A. Lieberman, Marty Alvarez-Reeves, MS 3, Prof. Tiina Reponen, PhD 4, Dr. MD 5, Hugh A. Sampson, MD, FAAAAI 6, Dr. Madhundra Sivaku- Gary Adamkiewicz, PhD3, Dr. Patrick Ryan, PhD 5, Doug Brugge, mar1, Dr. Araya Yuenyongviwat, MD 7 and Dr. Mariona Pascal, PhD6, David Turcotte, ScD 7, Fuyuen Yip, PhD, MPH 8, Kanta Sir- PhD8, 1Mount Sinai School of Medicine, New York, NY, 2Icahn car, PhD, MPH 8, Benjamin Blount, PhD 9, K. Udeni Alwis, PhD 9, School of Medicine at Mount Sinai, New York, NY, 3424 General Connie Sosnoff, MA 9, Peter Ashley, DrPH 10 , Curtis Hedman, Military Training Hospital, Thessaloniki, Greece, 4First Pediatric PhD11 , Steve Strebel, BS 11 , Behrooz Behbod, MBChB, MSc, Department, Aristotle University of Thessaloniki, Hippokration ScD1, Matthew Lozier, PhD, MPH 1 and Dr. Ginger L. Chew, General Hospital, Thessaloniki, Greece, 5University of Tennessee, ScD, MSPH8, 1Epidemic Intelligence Service, Centers for Disease Memphis, TN, 6Pediatrics, Icahn School of Medicine at Mount Si- Control and Prevention, Atlanta, GA, 2National Center for Immuni- nai, New York, NY, 7Prince of Songkla University, Songkhla, Thai- zation and Respiratory Diseases, Centers for Disease Control and land, 8Servei d’Immunologia, Centre de Diagnostic Biomedic. Prevention, Atlanta, GA, 3Harvard School of Public Health, Boston, Hospital Clinic., Barcelona, Spain MA, 4University of Cincinnati, Cincinnati, OH, 5Cincinnati Chil- 805 Microparticles Encapsulated With Antigen Protect Against dren’s Hospital Medical Center, Cincinnati, OH, 6Tufts University Sensitization and Reduce Anaphylactic Reactivity In a Food Al- Health Sciences, Boston, MA, 7Center for Family, Work and Com- lergy Model munity, University of Massachusetts Lowell, Lowell, MA, 8Air Pol- Dr. Karen B. Chien, PhD , Northwestern University, Chicago, IL lution and Respiratory Health Branch, Division of Environmental and Dr. Paul Bryce, PhD, Division of Allergy-Immunology, Depart- MONDAY Hazards and Health Effects, National Center for Environmental ment of Medicine, Feinberg School of Medicine, Northwestern Health, Centers for Disease Control and Prevention, Atlanta, GA, University, Chicago, IL 9Division of Laboratory Sciences, National Center for Environmen- 806 Over-The-Counter Dietary Supplements Genistein and Iprifla- tal Health, Centers for Disease Control and Prevention, Atlanta, vone Suppress Peanut Allergy Symptoms GA, 10 Office of Healthy Homes and Lead Hazard Control, U.S. De- Ms. Lisa Chang, BS 1, Ms. Mohanapriya Kamalakannan, MS 1, Mr. partment of Housing and Urban Development, Washington, DC, Matthew Stadler 1, Hugh A. Sampson, MD, FAAAAI 2 and Madhan 11 Wisconsin State Lab of Hygiene, Madison, WI Masilamani, PhD1, 1Icahn School of Medicine at Mount Sinai, New 800 A Systematic Analysis Of Pollen Transcriptomes From Plant York, NY, 2Pediatrics, Icahn School of Medicine at Mount Sinai, Allergens Reveals Conserved Targets Of Immune Responses New York, NY Dr. Bjoern Peters 1, Dr. Jason Greenbaum 1, Dr. Veronique M. 807 Analyzing Casein-Specific IL-4 and IL-13 Secreting T-Cells: A Schulten1, Dr. Denise Baker 1, Dr. April Frazier 1, Dr. Alessandro Reliable Tool For Diagnosis Of Cow’s Milk Allergy Sette, Dr. Biol. Sci. 1, Dr. Michael Wallner 2 and Mrs. Heidi Hofer2, Dr. Benedicte Michaud, MD, PhD 1,2, Dr. Joseph Aroulandom, 1La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2Uni- MD 3, Mrs. Nour Ba €ız, PhD4, Dr. Flore Amat, MD 3, Dr. Rahel e versity of Salzburg, Salzburg, Austria Gouvis-Echraghi, MD 3, Dr. Sophie Candon, MD, PhD 1,2, Mr. 801 Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Remy Couderc, PhD PharmaD5, Prof. Jean-Francois , MD, Th2 Immunity In Children PhD1,2, Prof. Lucienne Chatenoud, MD, PhD 1,2 and Prof. Jocelyne Kinjal M. Hew, PhD 1, Annett I. Walker, MD 1, Arunima Kohli 1, Just, MD, PhD3,4, 1Universit e Paris Descartes, Sorbonne Paris Cit e, Aleena Syed1, Cameron McDonald-Hyman 1, Zheng Li, PhD, France, 2Institut national de la sant e et de la recherche m edicale, MPH2, Andreas Sjodin, PhD 2 and Dr. Kari C. Nadeau, MD, PhD, Unite U1013, Paris, France, 3Allergology department, Trousseau

137 AB348 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

hospital AP-HP–UPMC Paris 6, France, 4EPidemiology of Allergic and Dr. Anju T. Peters, MD, FAAAAI 1, 1Department of Medicine, and Respiratory diseases (EPAR) Department, UMR-S 707 IN- Division of Allergy-Immunology, Northwestern University Fein- SERM, UPMC Paris 6, France, 5Service de Biochimie et Biologie berg School of Medicine, Chicago, IL, 2University of Chicago, Moleculaire, Trousseau hospital AP-HP, Paris, France IL, 3Department of Medicine, Northwestern University Feinberg 808 Growth Of Children Aged 2-17 With Cow’s Milk, Peanut, and School of Medicine, 4Northwestern University, Chicago, IL, 5De- Egg Allergy In NHANES partment of Otolaryngology, Northwestern University Feinberg Dr. Karen Robbins, MD 1, Robert A. Wood, MD, FAAAAI 2 School of Medicine, Chicago, IL, 6Division of Allergy-Immunol- and Corinne Keet, MD, MS 2, 1Johns Hopkins University ogy, Department of Medicine, Northwestern University Feinberg School of Medicine, 2Johns Hopkins University Medical Center, School of Medicine, Chicago, IL Baltimore, MD 815 Meta-Analysis Of Gene Expression Microarrays Reveals Novel Biomarkers Consistent With Altered Functionality Of Mucosal Barrier In Patients With Chronic Rhinosinusitis Epidemiology Dr. Sergejs Berdnikovs, PhD 1, Dr. Atsushi Kato, PhD 2, Mr. James Norton, MS 2, Ms. Lydia Suh, BSc 2, Dr. Robert C. Kern, MD 3, Dr. David Conley, MD 3, Dr. Rakesh Chandra, MD 4, Dr. Anju T. Peters, 4605 2 2 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM MD, FAAAAI , Dr. Leslie C. Grammer, MD, FAAAAI , Ms. Kathleen E. Harris, BSc 2, Dr. Michael Platt, MD 5, Dr. Ralph Met- 809 Allergic Causes Of Death In The United States son, MD 6 and Dr. Robert P. Schleimer, PhD FAAAAI 7, 1Division of Dr. Susan J. Kim, MD , Kaiser Permanente Southern California, Allergy-Immunology, Northwestern University Feinberg School of Los Angeles, CA and Dr. Jordan C. Brooks, PhD, MPH, Life Ex- Medicine, Chicago, IL, 2Department of Medicine, Division of Al- pectancy Project, San Francisco, CA lergy-Immunology, Northwestern University Feinberg School of 810 Death From Anaphylaxis Is a Reassuringly Unusual Outcome 3 1 Medicine, Chicago, IL, Department of Otolaryngology, Northwest- Dr. Larry Borish, MD, FAAAAI , Dr. Theodore Danoff, MD, 4 2 2 1 ern University Feinberg School of Medicine, Chicago, IL, North- PhD and Dr. Liyuan (Larry) Ma, PhD , Asthma and Allergic western University, Chicago, IL, 5Department of Otolaryngology, Diseases Center, Carter Center for Immunology Research, Uni- 6 2 Boston Medical Center, Boston University, Boston, MA, Depart- versity of Virginia, Charlottesville, VA, Endo Pharmaceuticals ment of Otology and Laryngology, Harvard Medical School, Bos- Inc. ton, MA, 7Division of Allergy-Immunology, Department of 811 Allergic Rhinitis, Asthma and Cardiovascular Disease Medicine, Northwestern University Feinberg School of Medicine, Dr. Angelina M. Crans Yoon, MD 1, Dr. Anne M. Staveren, MD 1, 1 Chicago, IL Dr. Michael S. Kaplan, MD, FAAAAI , Dr. Javed Sheikh, MD, 816 Evidence For Immunoglobulin D In Patients With Chronic Rhi- FAAAAI 2 and Dr. Bruce J. Goldberg, MD, PhD, FAAAAI 1, 1Kaiser 2 nosinusitis Permanente, Los Angeles, CA, Kaiser Permanente Los Angeles Dr. Jin Young Min, MD, PhD 1, Dr. Robert C. Kern, MD 1, Dr. Medical Center, Los Angeles, CA Kathryn E. Hulse, PhD 2, Dr. Rakesh Chandra, MD 2, Dr. David 812 Pre-Natal and Early Life Predictors Of Atopy In Canadian Conley, MD 1, Ms. Lydia Suh, BSc 3, Mr. Roderick Carter, Children: Results Of The Family Study 3 3 1

MONDAY 1 1 BSc , Mr. James Norton, MS , Julia H. Huang , Dr. Atsushi Tahira Batool, MBBS, FRCPC , Michael M. Cyr, MD, FRCPC , 3 4 1 Kato, PhD , Dr. Robert P. Schleimer, PhD FAAAAI and Dr. Judah Aryeh Denburg, MD, FRCPC, FAAAAI , Ms. Karleen Bruce K. Tan, MD 1, 1Department of Otolaryngology, Northwest- Schulze, MMath2, Sonia Anand, MD, FRCPC 2, Koon Teo, MD, 2 2 1 ern University Feinberg School of Medicine, Chicago, IL, FRCPC and Family Investigators , Division of Clinical Immunol- 2Northwestern University, Chicago, IL, 3Department of Medicine, ogy and Allergy, Department of Medicine, McMaster University, 2 Division of Allergy-Immunology, Northwestern University Fein- ON, Canada, Population Health Research Institute, Department berg School of Medicine, Chicago, IL, 4Division of Allergy-Im- of Medicine, McMaster University, ON, Canada munology, Department of Medicine, Northwestern University 813 Association Between Antibiotic Treatment In The First Six Feinberg School of Medicine, Chicago, IL Months Of Life and Clinical Allergic Outcomes At Ages 2 To 817 Oncostatin M Is Elevated In Chronic Rhinosinusitis and De- 3 Years 1 1 creases Barrier Function In Human Airway Epithelium Kyra Jones, MEd , Alexandra Sitarik, M.S. , Ms. Suzanne Hav- 1,2 2 1 1 Ms. Kathryn L. Pothoven , Mr. James Norton, MS , Dr. Christo- stad, M.A. , Ganesa Wegienka, PhD , Dr. Dennis Ownby, M.D. 2 2 2 3 pher Ocampo, MD, PhD , Ms. Lydia Suh, BSc , Mr. Roderick FAAAAI , Dr. Edward M. Zoratti, MD, FAAAAI and Dr. Chris- 2 3 1 1 Carter, BSc , Dr. Kathryn E. Hulse, PhD , Dr. Sudarshan Seshadri, tine Cole Johnson, PhD MPH FAAAAI , Department of Public 2 4 3 2 PhD , Dr. Bruce K. Tan, MD , Dr. Rakesh Chandra, MD , Dr. Anju Health Sciences, Henry Ford Hospital, Detroit, MI, Division of T. Peters, MD, FAAAAI 2, Ms. Kathleen E. Harris, BSc 2, Dr. David Allergy-Immunology and Rheumatology, Georgia Health Sci- 4 2 3 Conley, MD , Dr. Leslie C. Grammer, MD, FAAAAI , Dr. Robert ences University, Augusta, GA, Henry Ford Health System, De- C. Kern, MD 4 and Dr. Robert P. Schleimer, PhD FAAAAI 5, 1Dris- troit, MI kill Graduate Program, Northwestern University, Chicago, IL, 2De- partment of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Department of Otolar- Chronic Rhinosinusitis yngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Allergy-Immunology, Department of 4606 Medicine, Northwestern University Feinberg School of Medicine, Monday, March 3rd, 2014, 2:00 PM - 3:15 PM Chicago, IL 814 The Clinical Significance Of Specific Antibody Deficiency (SAD) 818 Immunologic Changes During Chronic Rhinosinusitis Exacer- Severity In Chronic Rhinosinusitis (CRS) bations Compared To Controls Dr. Anjeni Keswani, MD 1, Neha Mehrotra, MD 2, Dr. Angelica Dr. Shefali Samant, MD 1, Dr. Matthew A. Rank, MD, FAAAAI 2, Manzur3, Dr. Rakesh Chandra, MD 4, Dr. David Conley, MD 5, Dr. Dr. John B. Hagan, MD, FAAAAI 1, Dr. Erin O’Brien 1, Dr. Devyani Bruce K. Tan, MD 5, Dr. Leslie C. Grammer, MD, FAAAAI 1, Dr. Lal3 and Hirohito Kita, MD 1, 1Mayo Clinic, Rochester, MN, 2Mayo Robert C. Kern, MD 5, Dr. Robert P. Schleimer, PhD FAAAAI 6 Clinic, Scottsdale, AZ, 3Mayo Clinic, Phoenix, AZ

138 J ALLERGY CLIN IMMUNOL Abstracts AB349 VOLUME 133, NUMBER 2

Mechanisms of Asthma and Allergic Disease Cincinnati, OH and Dr. David I. Bernstein, MD, FAAAAI, Bern- stein Allergy Group, Cincinnati, OH 4607 826 Twins’ Increased Risk Of Asthma Compared To Singletons Is Monday, March 3rd, 2014, 2:00 PM - 3:15 PM Mediated By Gestational Age Vilhelmina Ullemar 1, Cecilia Lundholm, MSc 1 and Prof. Catarina 819 Allergen Challenge Increases Peripheral Blood CD84+ ILC2 In Almqvist, MD, PhD1,2, 1Department of Medical Epidemiology and Allergic Rhinitis Biostatistics, Karolinska Institutet, Stockholm, Sweden, 2Depart- Dr. David R. Scott, M.D. 1, Dr. Taylor A. Doherty, MD, FAAAAI 2, 3 3 ment of Women’s and Children’s Health, Astrid Lindgren Chil- Naseem Khorram, M.S. , Mr. Sean Lund, B.S. , Ms. Rachel Baum, dren’s Hospital, Karolinska University Hospital, Stockholm, B.S.3, Jinny Chang, M.D. 4, Mr. Peter Rosenthal, B.S. 3, Mr. Andrew 3 3 Sweden Beppu, B.S. , Dr. Marina Miller, MD, PhD and Dr. David H. 827 Viral Etiology Of Early Life Wheezing Illnesses Differentially Broide, MB ChB FAAAAI 5, 1Allergy and Asthma Center of West- 2 Predict Persistence Of Asthma In High-Risk Children ern Colorado, Medicine, University of California, San Diego, San 1 2 3 4 Dr. Frederick Rubner, MD , Dr. Daniel J. Jackson, MD , Mr. Mi- Diego, CA, University of California San Diego, Sansum Clinic, 1 1 5 chael D. Evans, MS , Dr. James E. Gern, MD, FAAAAI and Dr. Santa Barbara, Department of Medicine, San Diego, CA Robert F. Lemanske Jr., MD, FAAAAI 1, 1University of Wisconsin 820 Asthma Susceptibility Due To Environmental Programming Of School of Medicine and Public Health, Madison, WI, 2Pediatrics, Innate Immunity In Utero 1 1 University of Wisconsin School of Medicine and Public Health, Sarah Manners, BS , Rafeul Alam, MD, PhD, FAAAAI , David Madison, WI A. Schwartz, MD 2 and Magdalena M. Gorska, MD, PhD 1, 1Na- 2 828 Prevalence and Severity Of Wheezing In The First Year Of Life tional Jewish Health, Denver, CO, University of Colorado Denver Among Infants With Low Birth Weight School of Medicine, Aurora, CO Dr. Nathalia Barroso 1, Dr. Leila Borges, MD 1, Dr. Gustavo Wan- 821 Rhinovirus Challenge Augments Allergen Responsiveness In dalsen, MD 2, Dr. Elaine Prestes 3, Prof. Herberto J. Chong Neto, Basophils Of Atopic Asthmatics MD, PhD, FAAAAI 4, Prof. Nelson A. Rosario, MD, PhD, Rachana Agrawal, PhD, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 5, Dr. Ana Carolina Dela Bianca 6, Dr. Carolina Aranda 7, FAAAAI, Peter W. Heymann, MD and Judith A. Woodfolk, Dr. Decio Medeiros 6, Prof. Emanuel Sarinho, Prof. PHD 8, Dr. Lil- MBChB, PhD, FAAAAI, University of Virginia, Charlottesville, lian SANCHEZ LACERDA Moraes, MD, MSc 9, Dr. Javier Mal- VA lol10 and Prof. Dirceu Sole, MD, PhD7, 1UNIFESP, Brazil, 822 Der p 3 Allergen Activated Ano-1 Channel On Afferent Airway 2UNIFESP, Sao Paulo, Brazil, 3State University of Para, 4Federal Nerves Regulates Th2 Cell Responses 5 1 2 University of Parana, Brazil, Federal University of Parana, Curi- Mr. Mayur Patil, MS , Dr. Edward G. Brooks, MD , Dr. Michael 6 7 1 3 1 tiba, Brazil, Federal University of Pernambuco, Federal Univer- Henry, D.D.S, PhD and Dr. Armen Akopian, PhD , UTHSCSA, 8 2 sity of Sao Paulo, Sao Paulo, Brazil, UFPE, Universidade san antonio, TX, Univ. Texas Health Science Center San Antonio, 9 3 Federal de Pernambuco, Brazil, Federal University of Mato San Antonio, TX, UTHSCSA, San Antonio, TX Grosso, 10 University of Santiago de Chile 823 Increased Serum Soluble ST2 In Asthmatic Children and Re- 829 Interactive Exploration Of Microbial Exposure, Asthma and current Early Wheezers Allergy Using a Web-Based Tool Prof. Hai Lee Chung, MD, PhD and Dr. Eun Joo Lee, Catholic Jeremy Wildfire 1, Mr. Agustin Calatroni, MA MS 1, Dr. Susan V. University of Taegu, Taegu, South Korea Lynch, PhD 2, Dr. Homer A. Boushey Jr., MD, FAAAAI 3, Dr. Kei Fujimura, PhD2, Dr. Marcus Rauch, PhD 2 and Henry Lynn 1, 1Rho, Inc., Chapel Hill, NC, 2University of California San Fran- cisco, San Francisco, CA, 3University of California, San Francisco, The Impact of Environmental Factors on Asthma San Francisco, CA 830 Is There a Link Between Uncontrolled Asthma and Sensitiza- 5201 tion To Inhalant Allergens? Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM Dr. Majdy Qutub, MD 1, Prof. Emad Abdulkader Koshak, MD 1, 824 High Traffic Pollution Exposure Is Significantly Associated Dr. Moufag Tayeb 2 and Dr. Mohammed Alrabea 1, 1King Abdul With Poorer Asthma-Related Quality Of Life In Older Asth- Aziz University, Jeddah, Saudi Arabia, 2King Abdul Aziz Univer- matics sity, Rabigh, Saudi Arabia Dr. Jennifer A. Kannan 1, Dr. David I. Bernstein, MD, FAAAAI 2, 831 Allergy To Cockroaches: The Need For Standardization Of Ex- Ms. Cheryl Koff Bernstein, RN BSN CCRC 3, Dr. Patrick Ryan, tracts For Clinical Practice PhD1,4, Dr. Jonathan A. Bernstein, MD, FAAAAI 5, Dr. Manuel S. Prof. Emanuel Sarinho, Prof. PHD , UFPE, Universidade Federal Villareal, MD, FAAAAI 1, Dr. Andrew M. Smith, MD, FAAAAI 6, de Pernambuco, Brazil, Dr. Filipe Wanick Sarinho, Md, IMIP, Bra- Dr. Peter Lenz 1 and Dr. Tolly Epstein, MD, MS 7, 1University of zil, Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Cincinnati Medical Center, Cincinnati, OH, 2Bernstein Allergy Sao Paulo, Brazil and Dr. Isabela Londres, UFPE Group, Cincinnati, OH, 3Bernstein Clinical Research Center, 832 Are Environmental Factors More Important Than Genetic Fac- LLC, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical tors In Incident Asthma? Center, Cincinnati, OH, 5Division of Immunology Allergy & Rheu- Dr. Efren L. Rael, MD, FAAAAI , Allergy/Immunology, Penn matology, University of Cincinnati Medical Center, Cincinnati, OH, State University College of Medicine, Hershey, PA 63255 Eden Ave., HPB 350, University of Cincinnati Medical Cen- 833 Sensitization In Patients With Allergic Difficult-To-Control ter, Cincinnati, OH, 7Allergy Partners of Central Indiana, Indianap- Asthma olis, IN Dr. Rosana C. Agondi, MD, PhD 1, Dr. Bruna Saliba 2, Dr. Carla 825 Effect Of Early Exposure To Traffic Related Air Pollution On Bisaccioni, MD 1, Dr. Marcelo Vivolo Aun, MD 1, Prof. Jorge Kalil, The Asthma Predictive Index and Asthma At Age 7 MD, PhD1 and Prof. Pedro Giavina-Bianchi, MD, PhD, Dr. Priyal Amin, DO , University of Cincinnati, College of Medi- FAAAAI 1,3, 1Clinical Immunology and Allergy Division, Univer- cine, Cincinnati, OH, Afghanistan, Prof. Linda Levin, PhD, Univer- sity of Sao Paulo, Sao Paulo, Brazil, 2Clinical Immunology and sity of Cincinnati, Cincinnati, OH, Dr. Tolly Epstein, MD, MS, Allergy Division University of S ^ao Paulo, Brazil, Brazil, 3Clinical

Allergy Partners of Central Indiana, Indianapolis, IN, Dr. Patrick Imunnology and Allergy Division, University of Sao Paulo, TUESDAY Ryan, PhD, Cincinnati Children’s Hospital Medical Center, Boston, MA

139 AB350 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

834 Sensitization To Inhalant Allergens In Elderly Patients Of An 842 The Simplified Method For Eucapnic Voluntary Hyperventila- Allergy Clinic In Rio De Janeiro tion (EVH) May Be Useful To Discriminate Between Hyperven- Dr. Jose Luiz M. Rios, MD, PhD , Dr. Luiz C G Arcanjo, Fabio C tilation and Gastroesophageal Reflux Disease (GERD) Induced Kuschnir, Joao BM Rios and Ana CS Oliveira, Policlinica Geral do Bronchospasm Rio de Janeiro, Brazil Dr. Richard R. Rosenthal, MD 1,2, Mr. Harvey Howe, BS 3 and Mr. Paul Knause, BS 3, 1Allergy and Clinical Immunology, Johns Hop- kins University School of Medicine, Baltimore, MD, 2INOVA Fair- fax Hospital, Fairfax, VA, 3Self 843 A Young Adult With Increased Variability Of FEF25-75 Rela- tive To FEV1 Post-Bronchial Thermoplasty Diagnostic Modalities of Asthma Dr. Amy M. CaJacob, MD 1, Dr. Mark H. Kalenian, MD, FAAAAI 2, Dr. John T. Anderson, MD 1, Dr. Mark Dransfield 3 and 5202 Dr. Jennifer Trevor, MD 1, 1University of Alabama at Birmingham, Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM Birmingham, AL, 2Alabama Asthma and Allergy, PC, Dothan, AL, 835 The Evaluation Of Airway Obstruction By Lung Sound Analy- 3University of Alabama School of Medicine, AL sis In The Patients With Asthma Dr. Terufumi Shimoda, MD 1, Dr. Yukio Nagasaka, MD 2, Dr. Yasushi Obase, MD 3, Dr. Michiyoshi Imaoka, MD 1, Dr. Tomoaki Iwanaga, MD 1 and Dr. Reiko T. Kishikawa, MD 1, 1Fukuoka Na- tional Hospital, Fukuoka, Japan, 2Kyoto Respiratory Center, Basic and Translational Immunology Otowa Hospital, Kyoto, Japan, 3Kawasaki Medical School, Kur- ashiki, Japan 5203 836 IOS Is Useful In Younger Children Who Cannot Perform Spi- Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM rometry 844 Interferon-a-Release~ Assay Prevents Unnecessary Tuberculosis Dr. Shintaro Okazaki, MD , Hiroki Murai, MD, PhD, Hisako Hay- Therapy In Individuals With Positive Tuberculin Skin Test ashi, MD, Akiko Kawakita, MD, Motoko Yasutomi, MD, PhD, Mit- Dr. Vered Schichter-konfino and Prof. Elias Toubi, Bnai-Zion sufumi Mayumi, MD, PhD and Yusei Ohshima, MD, PhD, Medical Center, Rappaport Faculty of Medicine, Technion, Haifa- University of Fukui, Fukui, Japan Israel, Haifa, Israel 837 The Association Of Spirometry With Asthma Control and 845 High Dimensional Single-Cell Mass Cytometry Demonstrates Asthma Morbidity In Inner City Schoolchildren With Asthma Conserved Human Toll-Like-Receptor Activation Signatures Dr. Watcharoot Kanchongkittiphon, MD, PhD 1,2, Dr. Jonathan Dr. Elena Hsieh, MD 1, Dr. William O’Gorman, PhD 2, Ms. Erica M. Gaffin, MD, MMSc 1,3, Dr. Lianne S. Kopel, MD 1,3, Dr. William Savig2, Dr. Pier Federico Gherardini, PhD 2, Prof. Mark Davis, J. Sheehan, MD 1,3, Dr. Sachin N. Baxi, MD 1,3, Dr. Perdita Permaul, PhD2 and Prof. Garry Nolan, PhD2, 1Allergy and Immunology, MD 3,4, Dr. Diane R. Gold, MD, MPH 3,5 and Dr. Wanda Phipatana- Stanford University, Stanford, CA, 2Stanford University-Microbiol- kul, MD, MS, FAAAAI 1,3, 1Boston Children’s Hospital, Boston, ogy & Immunology, Stanford, CA MA, 2Ramathibodi Hospital, Mahidol University, Bangkok, Thai- 846 Heterogenous Nuclear Ribonucleoprotein L Regulates The Se- land, 3Harvard Medical School, Boston, MA, 4Division of Pediatric lective Expression Of Glucocorticoid Receptor Translational Allergy/Immunology, Massachusetts General Hospital, Boston, Isoforms In HL-60 Cells MA, 5Channing Laboratory, Brigham and Women’s Hospital, Bos- Newton Li, MD , Ingrid Bender and Nick Lu, PhD, Division of Al- ton, MA lergy and Immunology, Department of Medicine, Northwestern 838 Impulse Oscillometry (IOS) Is Easier Than Spirometry For University Feinberg School of Medicine, Chicago, IL Older Asthmatic and Non-Asthmatic Subjects 847 Dendrimeric Silica Particle Composites For IgE Determination Dr. Michael C. Balduzzi, MD 1, Dr. Adam Updegraff, DO 1, Dr. In Patients Allergic To Amoxicillin Kerri Rawson, Ph.D, MS 2, Dr. Brice Taylor, MD 3, Dr. Monroe J. Dr. Maria Isabel Monta nez,~ PhD1,2, Dr. Yolanda Vida, PhD 2,3, Dr. King, DO, FAAAAI 4 and Dr. Richard F. Lockey, MD 5, 1University Adriana Ariza, PhD1, Dr. Cristobalina Mayorga, PhD 1, Dr. Maria of South Florida, Tampa, FL, 2Washington University School of Salas, MD, PhD4, Dr. Miguel Blanca, MD, PhD 4, Dr. Ezequiel Medicine of Medicine, St. Louis,, MO, 3Morsani College of Med- Perez-Inestrosa, PhD2,3 and Dr. Mar ıa Jos e Torres, MD, PhD 4, 1Re- icine, University of South FLorida, Tampa, FL, 4University of search Laboratory for Allergic Diseases, Hospital Regional Universi- South Florida, Largo, FL, 5Division of Allergy and Immunology, tario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 2Andalusian Department of Internal Medicine, University of South Florida Mor- Centre for Nanomedicine and Biotechnology, BIONAND, Malaga, sani College of Medicine and James A. Haley Veterans’ Affairs Spain, 3Organic Chemistry, University of Malaga, Malaga, Spain, Hospital, Tampa, FL 4Allergy Service, Carlos Haya Hospital, M alaga, Spain

TUESDAY 839 Clinical and Spirometric Characteristics In Young Patients 848 Murine Splenocytes From Peanut-Allergic Donors Transfer With Intermittent and Mild Persistent Atopic Asthma Peanut Allergy To Na €ıve, Irradiated Recipient Mice Prof. Vera Tsybulkina 1, Dr. N. Kurmaeva 1, Dr. Nicolai Tsybulkin 1 Daphne Moutsoglou, BS and Dr. Stephen C. Dreskin, MD, PhD, and Prof. Lawrence M. DuBuske, MD, FAAAAI 2, 1Kazan State FAAAAI, University of Colorado Denver, Aurora, CO Medical University, Russia, 2George Washington University School 849 Alternaria-Induced Releases Of IL-1 Alpha and IL-1 Beta of Medicine, DC From Airway Epithelial Cells Through Syk and PKC Signaling 840 Clinical Impact Of Molecular Diagnosis In Dog Allergy Pathways Prof. Joaquin Sastre, MD, PhD, FAAAAI and Ms. Silvia Uriarte, Dr. Yonghan Sun , gil hospital, Incheon, South Korea and Hirohito Fundacion Jim enez Dıaz, Madrid, Spain Kita, MD, Mayo Clinic Rochester, Rochester, MN 841 Asthma As An Unrecognized Risk Factor For Herpes Zoster In 850 Transmaternal Bisphenol A Exposure Accelerates Diabetes Adults: A Population-Based Case-Control Study Type 1 Development In NOD Mice Dr. Young J. Juhn, MD, MPH 1, Dr. Hyo-Jin Kwon 1, Dr. Duk Won Dr. Johanna Bodin 1, Dr. Anette Kocbach Bølling 1, Dr. Rune Bang1, Dr. Eun Na Kim 1, Peter Wollan 2 and Mr. Brian Lahr 2, 1Dept Becher1, Prof. Frieke Kuper 2, Prof. Martinus Lovik 1 and Dr. Unni of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, C. Nygaard 1, 1Norwegian Institute of Public Health, Oslo, Norway, MN, 2Mayo Clinic, Rochester, MN 2TNO Nutrition and Food Research, Zeist, Netherlands

140 J ALLERGY CLIN IMMUNOL Abstracts AB351 VOLUME 133, NUMBER 2

851 Soluble Type I Interferon Receptor 2 and Soluble Type II Inter- Vanderbilt University School of Medicine, Nashville, TN, 3Allergy, feron Receptor 1 Are Independently Regulated Pulmonary, and Critical Care Medicine, Department of Medicine, Van- Thomas B. Lavoie, PhD , Taher Fatakdawala, Xiao-Hong Lin, Mi- derbilt University School of Medicine, Nashville, TN chael Skawinski, Jonathan Ferriera and Tara Stauffer, PBL Assay 860 Influence Of Dietary Fiber On Cellular Immunity In Experi- Science mental Vitamin Deficiency 852 Regulation Of Innate Immune Recognition Of Viral Infection Dr. Roman Khanferyan, MD, PhD 1, Dr. E.N. Trushina 2, O.K. Mus- By Epigallocatechin Gallate tafina 3, V.M. Kodentzova 2 and Prof. Lawrence M. DuBuske, MD, Dr. Christina L. Nance, PhD 1,2, Melinda Mata, B.S. 1, Ashley FAAAAI 4, 1Insitute of Nutrition, Russian Academy of medical Sci- McMullen, B.S.1, Sean McMaster, B.S. 1 and Dr. William T. ences, Moscow, Russia, 2Insitute of Nutrition Russian Academy of Sci- Shearer, MD, PhD, FAAAAI 1,2, 1Baylor College of Medicine, ences, Russia, 3Institute of Nutrition Russian Academy of Sciences, 2Texas Children’s Hospital Russia, 4George Washington University School of Medicine, DC

853 Prostaglandin I2 (PGI2) Inhibits IL-33-Induced Type 2 Cyto- 861 Evaluation Of Cytokine Levels In Patients With Active Pulmo- kine Responses By Mouse CD4 T Cells nary Tuberculosis Their Household Contacts-A Follow Up Weisong Zhou, PhD 1, Jian Zhang, MS 1, Kasia Goleniewska 2 and Study Dr. R. Stokes Peebles Jr., MD, FAAAAI 1, 1Division of Allergy, Pul- Ms. Ramya Sivangala1, Ms. Meenakshi Ponnana 1, Ms. Shruthi monary and Critical Care Medicine, Vanderbilt University School Thada1, Mrs. Lavanya Joshi 1, Dr. Vijayalakshmi Valluri 1,2 and Dr. of Medicine, Nashville, TN, 2Allergy, Pulmonary, and Critical Sumanlatha Gaddam1, 1Bhagwan mahavir medical research center, Care Medicine, Department of Medicine, Vanderbilt University , India, 2LEPRA India—Blue Peter Public Health & Re- School of Medicine, Nashville, TN search Centre, Hyderabad, India 854 Sequencing Of The ST2 Gene and The Identification Of Genetic 862 Semaphorin 4C Is An Intrinsic Regulator Of Cell-Cell Interac- Determinants Of Serum Total ST2 Levels: Strong Evidence For tion In Th2 Stimulated Memory-B-Cells Replication Across European and African American Popula- Ms. Marianne Beland1, Dr. Marylin Desjardins, MD 1,2, Ms. Di tions Xue3 and Dr. Bruce D. Mazer, MD, FAAAAI 4,5, 1Meakins-Christie Dr. Rasika A. Mathias, ScD 1, Lili Huang, MPH 1, Dr. Candelaria I. Laboratories, Montreal, QC, Canada, 2Division of Allergy and Clin- Vergara, MD, PhD 1, Dr. Li Gao, MD, PhD 1, Nicholas M. Rafaels 1, ical Immunology, Department of Paediatrics, McGill University Joseph Potee1, Mrs. Monica Campbell 1, Dr. Hironori Masuko, MD, Health Centre, Montreal, QC, Canada, 3Mcgill university, Montreal, PhD1, Justyna Fert-Bober 2, James Snider 3, Dr. Margaret Taub, QC, Canada, 4Montreal Children’s Hospital, Montreal, QC, Can- PhD4, Dr. Ingo Ruczinski, PhD 4, Dr. Terri H Beaty, PhD 4, Dr. Jen- ada, 5Meakins-Christie Laboratories, Research Institute - McGill nifer E. Van Eyk, PhD 2 and Dr. Kathleen C. Barnes, PhD University Health Centre, Montreal, QC, Canada FAAAAI 1, 1Division of Allergy and Clinical Immunology, Depart- ment of Medicine, Johns Hopkins University, Baltimore, MD, 2De- partment of Medicine, Johns Hopkins University, Baltimore, MD, 3Critical Diagnostics, San Diego, CA, 4Johns Hopkins Bloomberg Innate Immunity and Primary School of Public Health, Johns Hopkins University, Baltimore, MD 855 Salmonella Typhimurium Impedes Innate Immunity With a Immunodeficiencies Mast Cell-Suppressing Tyrosine Phosphatase Sptp Hae Woong Choi 1, Rhea Brooking, PhD 1, Subham Neupane 1, 5204 Chul-Jin Lee, PhD1, Dr. Edward Miao, MD, PhD 2, Dr. Herman F. Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM Staats, PhD1 and Dr. Soman N. Abraham, PhD 1,3, 1Duke University 863 A Patient With a Novel Leukocyte Adhesion Deficiency and Py- Medical Center, Durham, NC, 2University of North Carolina at oderma Gangrenosum-Like Disease Chapel Hill, Chapel Hill, 3Duke-National University of Singapore, Dr. Jared I. Darveaux, MD 1, Dr. Anna Huttenlocher 2, Dr. Daniel Singapore, Singapore Bennett3, Dr. Judith Smith 3, Dr. Christine M. Seroogy, MD, 856 The Role Of Semaphorin 7A In Alternatively Activation Of FAAAAI 3 and Dr. James E. Gern, MD, FAAAAI 4, 1University of Wi- Macrophages soconsin, Madison, WI, 2University of Wisconsin, Madison, Madi- Prof. Hye-Ryun Kang, MD, PhD , Dr. Hyun Seung Lee, PhD, Ms. son, WI, 3University of Wisconsin, Madison, WI, 4University of Da Eun Park, B.A., Ms. Ji Won Lee, B.A., Prof. Woo-Jung Song, Wisconsin School of Medicine and Public Health, Madison, WI MD, Prof. Heung-Woo Park, MD, PhD, Prof. Sang Heon Cho, 864 Reduced Macrophages IL-12 Production After Stimulation By MD, PhD and Prof. Kyung-Up Min, MD, PhD, Department of In- BCG/INF-Gamma Suggestive Of Impaired INF-Gamma Path- ternal Medicine, Seoul National University College of Medicine, way Signalling In a Child With Disseminated Atypical Myco- Seoul, South Korea bacterial Infection and History Of Chemotherapy For 857 Immune Perturbation In Patients With Tgfbeta Pathway De- Langerhans Cell Histiocytosis fects Dr. Eliska Furlong, MD, PhD , Dr. Richard K.S. Loh, MD, Dr. Dat Q. Tran, MD 1, Mrs. Ellen Regalado 2 and Dr. Dianna Mile- FAAAAI, Dr. Grace Wooi Kee Gong, MD and Dr. Andrew wicz2, 1University of Texas Medical School at Houston, Houston, McLean-Tooke, MBChB, Princess Margaret Hospital for Children, TX, 2UTHealth Perth, Australia 858 Chemokine Receptors On Regulatory T Cell Surface, Surrogate 865 Sporadic Case Of Chronic Mucocutaneous Candidiasis (CMC) Markers For Intracellular Th1 and Th2 Cytokines Due To a Gain-Of-Function Mutation In STAT1 In a 13 Year Mr. Satoru Watanabe 1,2, Dr. Yoshiyuki Yamada 1 and Prof. Hiro- Old Female kazu Murakami2, 1Gunma Children’s Medical Center, Shibukawa, Dr. Aimee E. Baer , MD and Dr. Jennifer A. Shih, MD, Gunma, Japan, 2Gunma University Faculty of Medicine School of Emory University, Atlanta, GA Health Science, Maebashi, Gunma, Japan 866 A Young Boy With a Novel, Autosomal-Dominant Signal Trans- 859 IL-4 Signaling Attenuates gd T Cell IL-17A Protein Expression ducer and Activator Of Transcription 1 (STAT1) Hypermorphic Melissa T. Harintho, BS 1, Dr. Dawn C. Newcomb Baker, PhD 2, Jac- Mutation Presenting With Pneumocystis Jirovecii Pneumonia queline-Yvonne Cephus, BS 2, Kasia Goleniewska 3 and Dr. R. Stokes (PJP), Chronic Mucocutaneous Candidiasis (CMC), and Com- Peebles Jr., MD, FAAAAI 2, 1Department of Pathology, Microbiology, bined Immunodeficiency

and Immunology, Vanderbilt University School of Medicine, Nash- Dr. Matthew C. Altman, MD 1, Dr. David Hagin, MD 1, Dr. David TUESDAY ville, TN, 2Division of Allergy, Pulmonary and Critical Care Medicine, Buchbinder, MD 2, Dr. Suzanne Skoda-Smith, MD 3, Dr. Hans D.

141 AB352 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Ochs, MD 1 and Dr. Troy R. Torgerson, MD, PhD 1, 1University of Gonc¸alves, MD 3, Dr. In ^es Camelo Nunes 2 and Prof. Dirceu Sole, Washington, Seattle, WA, 2Children’s of Orange County, 3Seattle MD, PhD3, 1Division of Allergy and Clinical Immunology, Dept Childrens Hospital, Seattle, WA of Pediatrics, Escola Paulista de Medicina, Federal University of 867 Infections In Mannose-Binding Lectin Deficiency Patients S~ao Paulo, S ~ao Paulo, Brazil, S ~ao Paulo, Brazil, 2Universidade Fed- Dr. Mary K. Paul, MD 1,2, Dr. Christopher Chang, MD, PhD, eral de S ~ao Paulo, S ~ao Paulo, Brazil, 3Federal University of Sao FAAAAI 2, Dr. Magee DeFelice, MD 3, Dr. Gang Ye, PhD 4 and Paulo, Sao Paulo, Brazil Dr. Sam Soundar, PhD 5, 1Thomas Jefferson University Hospital, 875 Atopic Associations In Asthmatic Patients Readmitted Within Philadelphia, PA, 2Alfred I duPont Hospital for Children, Wilming- 30 Days To The Hospital ton, DE, 3Nemours/AI duPont Hospital for Children, Philadelphia, Dr. Larisa Buyantseva, MD, MS , Dr. Melissa Rossi, Prof. Jason PA, 4Nemours, Orlando, FL, 5Nemours Liao, PhD and Dr. Timothy Craig, D.O., Penn State University, Her- 868 LRBA Causes Immunodeficiency and Autoimmunity By Dereg- shey, PA ulating NFkB-Mediated Multiple Immune Effectors Critical 876 Pediatric Asthma Associated With Fungal Exposure For B Cell Activation Dr. Cecilia Nguyen, MD 1, Dr. Christina E. Ciaccio, MD, Dr. Jia-Wang Wang, PhD 1, Mrs. Michelle A. Reiser, MS 1, Mrs. FAAAAI 2 and Dr. Charles Barnes, PhD 2, 1Children’s Mercy Hospi- Kunyu Li, BS 1, Ms. Eileen Rifkin 1, Ms. Bangmei Wang 1, Dr. Nar- tals and Clinics, 2Children’s Mercy Hospital, Kansas City, MO asaiah Kolliputi, PhD 1 and Dr. Richard F. Lockey, MD 1,2, 1Division 877 Assessment Of Factors Associated With PPV23 Vaccine Uptake of Allergy and Immunology, Department of Internal Medicine, Uni- Among Young Adults With Asthma In Olmsted County, MN versity of South Florida, Morsani College of Medicine, Tampa, FL, Maria J. Bachman, Medical Student 1, Joshua Gauger, Medical 2James A. Haley Veterans’ Affairs Hospital, Tampa, FL Student2, Dr. Chriss Derauf, MD 3, Dr. Slavica Katusic, MD 3, Jen 869 Giscelli Syndrome: A Case Treated With a Hematopoietic Rand-Weaver 3, YuBin Choi 3, Elizabeth Krusemark 3 and Dr. Young Stems Cells From a Cord Blood J. Juhn, MD, MPH 3, 1Mayo Medical School, Rochester, MN, Dr. Marisol Rico-Arroyo , Instituto Mexicano del Seguro Social 2Mayo Medical School, 3Dept of Pediatric and Adolescent Medi- 870 Fungal Granuloma and Chronic Mucocutaneous Candidiasis cine, Mayo Clinic, Rochester, MN Due To Autosomal Dominant Gain Of Function STAT1 Mutation 878 Clinical Effectiveness In Allergic Airway Disease Of Oriton IgE Dr. Nauman Salim, MBBS , MD , University of South Florida, Chemiphar TM : A Rapid Determination System Of Allergen- Tampa, FL and Dr. Jennifer Leiding, MD, University of South Flor- Specific IgE ida, St. Petersburg, FL Dr. Tomoyuki Soma, MD 1,2, Dr. Ai Masumoto 2, Dr. Takehito Ko- 871 Impaired T-Independent IgM Responses Due To Irak-4-, bayashi, MD 2, Dr. Atsushi Kamijyo, MD 2, Dr. Yoshitaka Uchida 1,2, MyD88 Deficiency Or Splenectomy Prof. Kouichi Hagiwara, MD 1, Prof. Minoru Kanazawa, MD 1 and Dr. Paul J. Maglione, MD, PhD 1, Lin Radigan 1, Sam Black 1, Jes- Prof. Makoto Nagata, MD 1,2, 1Department of Respiratory Disease, sica Overbey 1, Dr. Emelia Bagiella 1, Dr. Isabelle Meyts 2, Prof. Saitama Medical University, Japan, 2Allergy Center, Saitama Med- Jean-Laurent Casanova, MD, PhD 3,4, Dr. Capucine Picard, MD, ical University, Japan PhD3 and Dr. Charlotte Cunningham-Rundles, MD, PhD, 879 Gender Differentially Contributes To Airway Hyperresponsive- FAAAAI 1, 1Mount Sinai Medical Center, New York, NY, 2Univer- ness In Adult Asthmatics sity Hospitals Leuven, Belgium, 3Hopital Necker-Enfants Malades, Dr. Jeong-Hee Choi, MD 1, Dr. Cheol-Hong Kim, MD 2, Prof. In-Gyu Paris, France, 4Rockefeller University, New York, NY Hyun, MD 3, Dr. Joo-Hee Kim, MD 4, Dr. Tae-Rim Shin, MD 5 and Dr. 872 Intestinal Perforation and Non-Tuberculous Mycobacterial Per- Sang-Myeon Park, MD 5, 1Dept. of Pulmonology and Allergy, Hal- itonitis In a Patient With Interleukin-1 Receptor Associated Ki- lym University Dongtan Sacred Heart Hospital, Hwaseong, South nase 4 Deficiency Korea, 2Dept. of pulmonology and Allergy, Hallym University Dong- Dr. Hana B. Niebur, MD , Dr. Nathan Tang, MD, FAAAAI and Dr. tan Sacred Heart Hospital, 3Hallym University Dongtan Sacred Heart Jennifer Leiding, MD, University of South Florida, St. Petersburg, Hospital, 4Hallym University School of Medicine, Anyang, 5Hallym FL University Kangnam Sacred Heart Hospital 873 Suspected Non-Infectious Prosthetic Valve Inflammatory Dehis- 880 Prevalence Of Sleep Disorders In Children With Asthma and cence In X-Linked Chronic Granulomatous Disease Its Association With The Level Of Control Of The Disease, Dr. Monica Bhagat, MD 1, Dr. Joshua A. Steinberg, MD 2, Dr. Smoking and Obesity Frank Silvestry, MD 3, Dr. Lea Surrey, MD 3, Dr. Andrea J. Apter, Dr. Lorena Rangel-Garza, MD 1, Prof. Sandra N. Gonzalez-Diaz, MD MA MSc FAAAAI 1, Dr. Patricia A. Takach, MD, FAAAAI 1 MD, PhD, FAAAAI 1, Dr. Alejandra Macias-Weinmann, MD 2, Prof. and Dr. Benjamin P. Soule, MD 1, 1University of Pennsylvania, Phil- Alfredo Arias-Cruz, MD, FAAAAI 1, Dr. Maria Del Carmen Zarate- adelphia, PA, 2Medical College of Wisconsin, Milwaukee, WI, Hernandez, MD 3, Dr. Idalia V. Yanez-Perez, MD 4 and Dr. Hilda 3UPENN, Philadelphia, PA Hernandez-Sanchez, MD 4, 1University Hospital Dr. Jose Eleuterio 873A The Effects Of Anti-Seizure Medications On Patients With An- Gonzalez, UANL, Monterrey, Mexico, 2Hospital Universitario tibody Deficiency Syndrome UANL, Monterrey, N.L., Mexico, 3University Hospital, Monterrey, 4

TUESDAY Dr. Tatyana Gavrilova, MD and Dr. Harumi Jyonouchi, MD, Mexico, Regional Center of Allergy and Clinical Immunology. Rutgers University of Medicine and Dentistry, Newark, NJ University Hospital ‘‘Dr. Jose Eleuterio Gonzalez’’., Monterrey, Mexico 881 Asthma and Allergic Diseases Of Preschool Children In Korea: Findings From The Pilot Study For The Korean Surveillance Survey For Childhood Asthma Epidemiology and Risk Factors of Asthma Prof. Ji Tae Choung, MD , Korea Univ. Medical Center, Seoul, Prof. Sungchul Seo, The Enviornmental Health Center for Asthma, 5205 Korea University, Seoul, Dr. YongMin Cho, The environmental Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM health center for asthma, Dr. Young Yoo, MD, PhD, Department 874 Risk Factors Associated With The Development Of Asthma of Pediatrics, College of Medicine, Korea University, Seoul, South and Allergic Rhinitis Among Adolescents Living In S ao~ Paulo – Korea; Department of Environmental Health Sciences, Mailman Brazil School of Public Health, Columbia University, New York, NY Dr. Fernanda Patini Furlan 1, Dr. Djanira Andrade 2, Danielli and Dr. Wonsuck Yoon, Department of Life Science and Biotech- Christinni Bichuete-Silva, MD 3, Dr. Tessa Rachel Tranquilini nology, Seoul, South Korea

142 J ALLERGY CLIN IMMUNOL Abstracts AB353 VOLUME 133, NUMBER 2

882 Atopic Characteristics Of Patients With Paroxysmal Vocal Arai, MD 3, Dr. Hirotaka Shimizu, MD 3, Dr. Yoshiyuki Yamada, Cord Dysfunction MD, PhD4, Dr. Yukihiro Ohya, MD, PhD 1, Dr. Hirohisa Saito, Casey Curtis, MD 1,2, Meagan W. Shepherd, MD 1,2, Gary Phillips, MD., PhD.2 and Dr. Kenji Matsumoto, MD, PhD 2, 1Division of Al- M.A.S.3 and Princess U. Ogbogu, MD, FAAAAI 1,2, 1Wexner Med- lergy, National Center for Child Health and Development, Tokyo, ical Center at the Ohio State University, Columbus, OH, 2Nation- Japan, 2Department of Allergy and Immunology, National Research wide Children’s Hospital, Columbus, OH, 3Wexner Medical Institute for Child Health and Development, Tokyo, Japan, 3Divi- Center at The Ohio State University, Columbus, OH sion of Gastroenterology, National Center for Child Health and De- 883 Relationship Of Allergen Sensitization and LUNG Function In velopment, Tokyo, Japan, 4Gunma Children’s Medical Center, Adults Patients With Asthma In Allergy Clinic In Monterrey, Shibukawa, Japan Mexico 890 Comprehensive Analysis Of Offending Milk Protein Compo- Dr. Hilda Hernandez Sanchez, MD , Prof. Sandra N. Gonzalez- nents In Non-IgE-Mediated Gastrointestinal Food Allergies Diaz, MD, PhD, FAAAAI, Prof. Alejandra Macias-Weinmann, By Antigen-Specific Lymphocyte Proliferation Test MD, Prof. Alfredo Arias-Cruz, MD, FAAAAI, Dr. Idalia Vanessa Dr. Tetsuo Shoda, M.D. , Dr. Ichiro Nomura, MD, PhD, Dr. Hide- Yanez-Perez, MD and Dr. Lorena Rangel-Garza, MD, University aki Morita, MD., PhD., Dr. Akio Matsuda, PhD, Dr. Hirohisa Saito, Hospital Dr. Jose Eleuterio Gonzalez, UANL, Monterrey, Mexico MD., PhD. and Dr. Kenji Matsumoto, MD, PhD, Department of Al- 884 Targeting Patient Eduation: Correlating Fluctuating Pollen lergy and Immunology, National Research Institute for Child Counts With Patient Online Inquiries Into Asthma and Allergic Health and Development, Tokyo, Japan Rhinitis 891 Milk Elimination Diet For Treatment Of Eosinophilic Esopha- Dr. John M. Kern, D.O. 1, Dr. Leonard Bielory, MD, FAAAAI 2,3 gitis and Mr. Spencer H. Luster 3,4, 1Rutgers University - NJMS, ocean- Elizabeth Erwin, MD 1, Patrice Kruszewski 2, Dr. John Russo, port, NJ, 2Robert Wood Johnson University Hospital, New Bruns- M.D.1 and Thomas A.E. Platts-Mills, MD, PhD, FAAAAI 3, 1Na- wick, NJ, 3STARx Allergy and Asthma Center, Springfield, NJ, tionwide Children’s Hospital, Columbus, OH, 2Nationwide Chil- 4University of Pennsylvania, Philadelphia, PA dren’s Hospital, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA 892 Pediatric Eosinophilic Esophagitis: A 10-Year Experience At a Canadian Tertiary Care Centre Eosinophilic Gastrointestinal Diseases Dr. Jason A. Ohayon, MD 1, Perri R. Tutelman 2, Dr. Jefferson Terry, MD, PhD 3 and Dr. Mary E. Sherlock, MB BCh, BAO, 5206 PhD2, 1Department of Pediatrics, McMaster Children’s Hospital, Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM McMaster University, Hamilton, ON, Canada, 2Department of Pe- 886 Elevated Exhaled Nitric Oxide Levels In Eosinophilic Esophagi- diatric Gastroenterology and Nutrition, McMaster Children’s tis Patients With and Without Atopy Hospital, McMaster University, Hamilton, ON, Canada, 3Depart- Michael Kagen, M.D.1, Zainab Kagen, MD 2, Prof. Steve L. Kagen, ment of Pathology and Molecular Medicine, MD, FAAAAI 3 and Joe Zondlo, M.D.3, 1University of Tennessee McMaster Children’s Hospital, McMaster University, Hamilton, College of Medicine-Chattanooga, Chattanooga, TN, 2University ON, Canada of Tennesee College of Medicine-Chattanooga, TN, 3Kagen Allergy 893 Clinical Characteristics Of Eosinophilic Esophagitis - a Case Clinic, Appleton, WI Series Of 30 Patients 887 Older Mice Intranasally Sensitized with Aspergillus Fumigatus Dr. Susana D. Piedade 1, Dr. Diana Silva 1,2, Dr. Bruno Sim oes~ 1,3, ^ 1 4 5 Develop Stronger Eosinophilic Esophageal Inflammation Com- Dr. Angela Gaspar , Dr. Sandra Morgado , Dr. Filipa Santos and pared to Their Younger Counterparts Dr. M ario Morais-Almeida 1, 1Immunoallergy Department, Hospital Dr. Antonella Cianferoni, MD, PhD 1, Simona Barni, MD 2, Cara CUF Descobertas, Lisbon, Portugal, 2Immunoallergy Department, Smith, BS 3, Valsamma Abraham, PhD 4, Peng Guan, BS 3, Dr. Fran- Hospital S~ao Jo ~ao, Oporto, Portugal, 3Pediatrics Department, Hos- cesca Saretta, MD 5, Katie Ruyman, BS 3, Hamid Bassiri, MD, PhD 3, pital Faro, Faro, Portugal, 4Gastroenterology Unit, Hospital CUF Dr. Kim E. Nichols, MD 6 and Dr. Jonathan M. Spergel, MD, PhD, Descobertas, Lisbon, Portugal, 5Pediatrics Department, Hospital FAAAAI 3,7 , 1The Children’s Hospital of Philadelphia, 2University of CUF Descobertas, Lisbon, Portugal Italy, Italy, 3Children’s Hospital of Philadelphia, 4University 894 Characteristics Of Eosinophilic Esophagitis Among Children of Pennsylvania, 5Ospedale Di Palmanova, ASS 5 Bassa Friulana, Pag- Living In Rural, Southern United States nacco, Italy, 6CChildren’s Hospital of Philadelphia, Philadelphia, PA, Ms. Erin O’Brien1,2, Dr. Troy Gibbons, MD 1,2, Dr. Amy M. Scur- 7The Children’s Hospital of Philadelphia, Philadelphia, PA lock, MD 3, Dr. Jennifer Olivier, MD 1,2, Mallikarjuna Rettiganti, 888 Cripto-1 Is Elevated In Pediatric Subjects With Eosinophilic PhD1,2, Maria Melguizo Castro 1,2, Ms. Peggy L. Chandler, Esophagitis APN1,2, Audrey Fendley, RD 2, Dr. Helen Casteel, MD 1,2, Dr. Mar- Lisa Beppu, BS 1, Arjun Andrew Anilkumar, BS 2, Richard Kurten, yelle VonLanthen, MD 1,2, Dr. Stephen Fiedorek, MD 1,2, Dr. Tamara PhD3, Ranjan Dohil, MD 4, David Broide, MB ChB 2 and Seema T. Perry, MD 1,2, Stacie M. Jones, MD 3,4 and Dr. Robbie D. Pesek 1,2, Sharma Aceves, MD, PhD, FAAAAI 5, 1University of California 1University of Arkansas for Medical Sciences, Little Rock, AR, San Diego, Department of Pediatrics, Division of Allergy and Im- 2Arkansas Children’s Hospital, Little Rock, AR, 3University of Ar- munology, 2University of California San Diego, Department of kansas for Medical Sciences and Arkansas Children’s Hospital, Lit- Medicine, Division of Allergy and Immunology, 3University of Ar- tle Rock, AR, 4Arkansas Children’s Hospital Research Institute, kansas for Medical Sciences, Little Rock, AR, 4University of Cal- Little Rock, AR ifornia San Diego, Rady Children’s Hospital, Department of 895 Failure To Thrive In a Pediatric Cohort With Eosinophilic Pediatrics, Division of Gastroenterology, 5Pediatrics, University Esophagitis of California San Diego, La Jolla, CA Dr. Brenda Paquet, MD, FRCPC 1, Dr. Philippe B egin, MD, MSc 889 Interleukin-33 and Thymic Stromal Lymphopoietin Are Prefer- FRCPC1, Louis P. Paradis, MD FRCPC FAAAAI 2, Dr. Eric Drouin, entially Elevated In The Sera Of Infants With Eosinophilic Gas- MD FRCPC 1 and Anne M. Des Roches, MD FRCPC FAAAAI 2, troenteritis 1Centre Hospitalier Universitaire Ste-Justine, Montreal, QC, Can- Dr. Ichiro Nomura, MD, PhD 1,2, Dr. Akio Matsuda, PhD 2, Dr. ada, 2Centre Hospitalier Universitaire Sainte-Justine, Montreal,

Tetsuo Shoda, MD 2, Dr. Hideaki Morita, MD., PhD. 2, Dr. Katsuhiro QC, Canada TUESDAY

143 AB354 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

896 Eosinophilic Esophagitis In The Puerto Rican Pediatric Popula- 905 Rituxan Hypersensitivity and Management tion Dr. Johnson T. Wong, MD, FAAAAI 1, Dr. Aleena Banerji, MD 1, Dr. Carmen M. Pimentel, MD , Dr. Angel M. Rivera, MD, Dr. Iona Dr. Timothy P. Lax, MD 2, Dr. Aidan Long, MD, FAAAAI 1, Dr. Mi- K. Malinow, MD, Dr. Cristina J. Ramos, MD, Dr. Anardi Agosto- chael T. Wilson, MD, PhD 1 and Dr. Caroline Sokol, MD, PhD 3, Mujica, MD, Dr. Rita Diaz, MD and Dr. Sylvette Nazario, MD, 1Division of Rheumatology, Allergy, and Immunology, Department University of Puerto Rico School of Medicine, San Juan, PR of Medicine, Massachusetts General Hospital, Harvard Medical 897 Challenges With Measurement Of IgE Antibodies To Minor School, Boston, MA, 2Division of Rheumatology, Allergy, and Im- Components In Food Allergy: Eosinophilic Esophagitis, Peanut munology, Department of Medicine, Massachusetts General Hospi- Allergy, and Delayed Anaphylaxis To Mammalian Meat tal, Harvard Medical School, Boston, MA, Boston, MA, Anubha Tripathi, MD 1, Lisa J. Workman, BA 1, Scott Commins, 3Massachusetts General Hospital MD, PhD1, Barrett Barnes, MD 2, Prof. Robert G. Hamilton, PhD 906 Diagnostic Evaluation Of Hypersensitivity Reactions To Beta- D.ABMLI FAAAAI 3, Thomas A.E. Platts-Mills, MD, PhD, lactam Antibiotics In A Large Population Of Children FAAAAI 1 and Elizabeth Erwin, MD 4, 1Division of Asthma, Allergy Dr. Maria J Torres, MD, PhD 1, Dr. Maria Angeles Zambonino 2, & Immunology, University of Virginia Health System, Charlottes- Dr. Jose Luis Corzo, MD 3, Dr. Candelaria Mu noz~ 3, Dr. Gloria Re- ville, VA, 2Division of Pediatric Gastroenterology, University of quena3, Dr. Adriana Ariza, PhD 4, Dr. Cristobalina Mayorga, PhD 5, Virginia Health System, Charlottesville, VA, 3Johns Hopkins Uni- Dr. Antonio Urda 3 and Dr. Miguel Blanca, MD, PhD 1, 1Allergy Ser- versity School of Medicine, Baltimore, MD, 4Nationwide Chil- vice, Carlos Haya Hospital, Malaga, Spain, 2Allergy Service, Car- dren’s Hospital, Columbus, OH los Haya Hospital, Malaga, Spain, Malaga, Spain, 3Pediatric 898 Serum IgE To Allergen Components In Patients With Eosino- Service, Carlos Haya Hospital, Malaga, Spain, 4Research Labora- philic Esophagitis tory for Allergic Diseases, Hospital Regional Universitario de Ma- Maria Slack, MD 1, Princess U. Ogbogu, MD, FAAAAI 2, Anubha laga - FIMABIS-IBIMA, Malaga, Spain, 5Research Laboratory for Tripathi, MD 3, Lisa J. Workman, BA 3, Thomas A.E. Platts-Mills, Allergic Diseases, Hospital Regional Universitario de Malaga - MD, PhD, FAAAAI 3 and Elizabeth Erwin, MD 4, 1Nationwide Chil- IBIMA, Malaga, Spain dren’s Hospital, Columbus, OH, 2Wexner Medical Center at the 907 Clinical Presentation and Outcomes Of Children Undergoing Ohio State University, Columbus, OH, 3Division of Asthma, Al- Evaluation For Drug Allergy lergy & Immunology, University of Virginia Health System, Char- Dara Mairiang, MD , Dr. Wiparat Manuyakorn, MD, Wasu Kam- lottesville, VA, 4Nationwide Children’s Hospital chaisatian, MD, Soamarat Vilaiyuk, MD and Suwat Benjaponpitak, 899 Eosinophilic Gastroenteritis Due To Egg Allergy Presenting As MD, Division of Pediatric Allergy/Immunology/Rheumatology, Acute Pancreatitis Department of Pediatrics, Faculty of Medicine Ramathibodi Hospi- Dr. Kevin Tse, MD , UCSD and Dr. Sandra C. Christiansen, MD, tal, Mahidol University, Bangkok, Thailand FAAAAI, Southern CA Permanente Med Grp, San Diego, CA 908 Analysis Of Drug Hypersensitivity Reactions In A Large Serie 900 Patient Ratings Of Various Eosinophilic Esophagitis Treatment Of Children Options Dr. Maria Angeles Zambonino 1, Dr. Candelaria Mu noz~ 2, Dr. Jose Dr. Samantha K. Lin, MD , Dr. Neelu Kalra, MD and Dr. Gisoo Ghaf- Luis Corzo, MD 2, Dr. Gloria Requena 2, Dr. Adriana Ariza, PhD 3, fari, MD, FAAAAI, Penn State Hershey Medical Center, Hershey, PA Dr. Cristobalina Mayorga, PhD 3, Dr. Antonio Urda 2, Dr. Miguel 901 Eosinophilic Esophagitis and Serum Eotaxin-3 Levels: A Non- Blanca, MD, PhD1 and Dr. Maria J Torres, MD, PhD 1, 1Allergy Ser- Invasive Method To Monitor Disease Activity vice, Carlos Haya Hospital, Malaga, Spain, 2Pediatric Service, Car- Dr. Cristina Jimenez-Aponte 1, Dr. Jose Torres-Silva 1, Dr. Eric los Haya Hospital, Malaga, Spain, 3Research Laboratory for Gonzalez-Hernandez1, Dr. Liza Gonzalez-Benitez 1, Dr. Mairim Allergic Diseases, Hospital Regional Universitario de Malaga - FI- Wiscovich-Torres 1, Dr. Carlos Camacho 1 and Dr. Vylma Velaz- MABIS-IBIMA, Malaga, Spain quez, MD 2, 1Hospital Episcopal San Lucas-Ponce, 2Hospital Epis- 909 Assessing IgE-Mediated Reactions In Children Presenting To copal San Lucas, Ponce, PR An Allergy Clinic With a Suspected Antibiotic Allergy 902 Evaluation Of Antigenic Triggers and Etiologies In Eosinophilic Mr. Christopher Mill, BSc 1, Dr. Marie-Noel Primeau, MD 2, Dr. Esophagitis: A Single Center Experience Christine Lejtenyi, MD 3, Dr. Elaine J. Medoff 3, Ms. Nofar Kimchi 4 Dr. Tanvi Patel , University of Florida, Gainesville, FL and Dr. Sa- and Dr. Moshe Ben-Shoshan, MD, MSc 5,6, 1Division of Clinical rah Glover, University of Florida at Gainesville, Gainesville, FL Epidemiology, Department of Medicine, McGill University Health 903 Eosinophilic Esophagitis and Selective IgA Deficiency. A New Centre, Montreal, QC, Canada, 2McGill University Health Center, Combined Disorder Montreal, QC, Canada, 3Montreal Children’s Hospital, Montreal, Dr. Eric Gonzalez Hernandez 1, Dr. Vylma Velazquez, MD 2, Dr. QC, Canada, 4Technion American Medical Students Program, Is- Carlos Camacho3 and Dr. Sheila Capre 1, 1Hospital Episcopal San rael, 5Division of Paediatric Allergy and Clinical Immunology, De- Lucas, 2Hospital Episcopal San Lucas, Ponce, PR, 3Hospital Epis- partment of Paediatrics, McGill University Health Center, copal San Lucas-Ponce Montreal, QC, Canada, 6Montreal Children’s Hospital, Montreal,

TUESDAY Canada 910 Hypersensitivity Drug Reactions (HDR) In Latin America. Sim- ilarities and Differences Between Children and Adults Dr. Ricardo Cardona-Villa, MD 1, Dr. Edgardo J. Jares, MD 2, Dr. Drug Allergy Maximiliano Gomez 3, Dr. Luis Felipe C. Ensina, MD 4, Dr. Mario Sanchez-Borges, MD, FAAAAI 5, Dr. Alfredo Arias Cruz 6, Dr. Car- 5207 los Serrano7, Dr. Mabel Noemi Cuello, MD 8, Ivan Cherrez 9, Dr. Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM Andrea Zanacchi10 , Prof. Alicia De Falco 11 , Dr. Silvana Monsell 2, 904 Cephalosporin Cross-Reactivity In Skin Test Dr. Adolfo Salvatierra 12 , Dr. Susana Barayazarra 10 , Dr. Susana Dr. Jong-Myung Lee, MD 1,2 and Dr. Min-Hye Kim 1,3, 1Regional Diez-Zuloaga1, Dr. Blanca Maria Morfin-Maciel, MD 13 , Dr. Paola Pharmacovigilance Center, Kyungpook National University Hospi- Toche Pinaud 14 , Dr. Sandra Gonz alez Dıaz6 and Dr. Juan F. Schuhl, tal, Daegu, South Korea, 2Department of Internal Medicine, Kyung- MD, FAAAAI 15 , 1Universidad de Antioquia, Medellin, Colombia, pook National University School of Medicine, Daegu, South Korea, 2C.M.P. SA, Buenos Aires, Argentina, 3Hospital San Bernardo, 3Department of Internal Medicine,Kyungpook National University Salta, Argentina, 4Universidade Federal de S ~ao Paulo, S ~ao Paulo, School of Medicine, Daegu, South Korea Brazil, 5Clinica El Avila, 6a transversal Altamira, piso 8,

144 J ALLERGY CLIN IMMUNOL Abstracts AB355 VOLUME 133, NUMBER 2

consultorio 803, Caracas., Caracas, Venezuela, 6Hospital Universi- FIMABIS-IBIMA, Malaga, Spain, 4Allergy Service, Carlos Haya tario, Monterrey, Mexico, 7Fundacion Valle del Lili, Cali, Colom- Hospital, Malaga, Spain bia, 8Consultorios San Juan, San Juan, Argentina, 9Respiralab - 915 Aspirin Allergy In a High Risk VA Population and Potential Hospital Kennedy, Guayaquil, Ecuador, 10 Nuevo Hospital San Ro- Benefit From Aspirin Desensitization que, Cordoba, Argentina, 11 Universidad Nacional de La Plata, La Bhavisha Patel, MD 1,2, Joseph Karls 2, Sandra Tompkins 2, Dawn Plata, Argentina, 12 Fundair, San Luis, Argentina, 13 Hospital Mocel, Nyland2, Jo Ann Clough 2, Jane Ludwig 2 and Sameer K. Mathur, Mexico City, Mexico, 14 Cl ınica Las Condes, Santiago, Chile, MD, PhD, FAAAAI 1,2, 1University of Wisconsin School of Medi- 15 British Hospital, Montevideo, Uruguay cine and Public Health, Madison, WI, 2William S. Middleton Vet- 911 Copy Number Variations In ALOX5 and PTGER1 Genes Are erans Hospital, Madison, WI Associated With Susceptibility To AERD and Mnsaid-UA 916 Novel Protocol For Successful Aspirin Desensitization In a Pa- Mrs. Maria Del Carmen Plaza Seron, Bsc. 1, Dr. Pedro Ayuso Par- tient With Laryngeal Angioedema To Aspirin ejo, PhD1, Dr. Natalia Blanca-L opez, MD, PhD1, Dr. Inmaculada Dr. Nikki Garg, MD , Dr. Pratik Patel, MD and Dr. Sindhura Bandi, Do na,~ MD, PhD2, Dr. Jose A Cornejo-Garcia, PhD 3, Dr. Mar ıa MD, Rush University Medical Center, Chicago, IL Jose Torres, MD, PhD 2, Dr. Javier Fern andez4, Dr. Jose Julio La- 917 Allergy To Beta-Lactams In Patients Consulting Allergology guna, MD, PhD5, Veronique Godineau 3, Ms. Miriam Osorio 6, Center Of The Antioquia University, Colombia Mrs. Luisa Galindo, RN 2, Dr. Gabriela Canto, MD, PhD 1 and Dr. Dr. Elizabeth Lopez 1, Dr. Kaddy Juliana Beltran 1, Dr. Jorge San- Miguel Blanca, MD, PhD2, 1Allergy Service, Infanta Leonor Hos- chez1 and Dr. Ricardo Cardona-Villa, MD 2, 1Universidad de Anti- pital, Madrid, Spain, 2Allergy Service, Carlos Haya Hospital, oquia, Colombia, 2Universidad de Antioquia, Medellin, Colombia Malaga, Spain, 3Research Laboratory, Carlos Haya Hospital, Ma- 918 Effect Of Penicillin Allergy On Outpatient Antibiotic Prescrip- laga, Spain, 4UMH Alicante G.University Hospital - Allergy tions At VA Hospital Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Madrid, Spain, Mark Biagtan, MD 1,2, Bryan Babler, BS Pharm RPh 2, Sujani Ka- 6Research Laboratory, Carlos Haya Hospital-FIMABIS, M alaga, kumanu, MD 1,2 and Sameer K. Mathur, MD, PhD, FAAAAI 1,2, Spain 1University of Wisconsin School of Medicine and Public Health, 912 Association Study Of Genes Involved In Mast Cell Activation Madison, WI, 2William S. Middleton Veterans Hospital, Madison, and Mnsaid-UA WI Dr. Pedro Ayuso Parejo, PhD 1, Mrs. Maria del Carmen Plaza- 919 Value Of Clavulanic Acid In Basophil Activation Test For Eval- Seron, Bsc1, Dr. Inmaculada Do na,~ MD, PhD2, Dr. Natalia uating Immediate Reactions To The Combination Amoxicillin- Blanca-Lopez, MD, PhD1, Dr. Jose A Cornejo-Garcia, PhD 3, Dr. Clavulanic Acid Maria J Torres, MD, PhD 2, Dr. Javier Fern andez4, Dr. Jose Julio La- Dr. Cristobalina Mayorga, PhD 1, Dr. Adriana Ariza, PhD 2, Dr. In- guna, MD, PhD5, Ms. Miriam Osorio 6, Veronique Godineau 3, Mrs. maculada Do na,~ MD, PhD3, Dr. Maria Angeles Zambonino 3, Dr. Luisa Galindo, RN 2, Dr. Cristobalina Mayorga, PhD 3, Dr. Gabriela Maria Isabel Montanez,~ PhD1, Dr. Maria Salas, MD, PhD 3, Ms. Canto, MD, PhD1 and Dr. Miguel Blanca, MD, PhD 2, 1Allergy Ser- Maria Dolores Ruiz3, Ms. Lidia Melendez, Lab. Tech. 1, Mrs. Maria vice, Infanta Leonor Hospital, Madrid, Spain, 2Allergy Service, D Ca namero~ 3, Dr. Miguel Blanca, MD, PhD 3 and Dr. Maria J Carlos Haya Hospital, Malaga, Spain, 3Research Laboratory, Carlos Torres, MD, PhD 3, 1Research Laboratory for Allergic Diseases, Haya Hospital, Malaga, Spain, 4UMH Alicante G.University Hospi- Hospital Regional Universitario de Malaga - IBIMA, M alaga, tal - Allergy Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Ma- Spain, 2Research Laboratory for Allergic Diseases, Hospital Re- drid, Spain, 6Research Laboratory, Carlos Haya Hospital- gional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, FIMABIS, Malaga, Spain 3Allergy Service, Carlos Haya Hospital, M alaga, Spain 913 Non-Steroidal Antiinflammatory Drugs (NSAIDs)-Induced 920 Persistence Of Penicillin Allergy Label Despite Documented Acute Urticaria: A Genome-Wide Association Study In The Tolerance Spanish Population Matthew Feldman, MD and Dr. David A. Khan, MD, FAAAAI, Dr. Jose A Cornejo-Garcia, PhD 1, Dr. Mike Lee 2, Dr. Natalia University Texas SW Medical Center, Dallas, TX Blanca-Lopez, MD, PhD3, Dr. Lieh-Bang Liou 4, Dr. Chien-Hsiun 921 Allergy To Betalactams In Brazil: Placebo Effect Or Misdiagno- Chen5, Dr. Inmaculada Do na,~ MD, PhD6, Veronique Godineau 1, sis? Dr. Jose Julio Laguna 7, Dr. F. Javier Fernandez, MD, PhD 8, Dr. Manoela Crespo-Magalh aes~ 1, Dr. Marcelo Vivolo Aun, MD 1, Dr. Pedro Ayuso Parejo, PhD 3, Mrs. Maria del Carmen Plaza- Dr. Roberta Almeida-Castro 2, Dr. Marisa Rosimeire Ribeiro, MD 3, Seron, Bsc3, Dr. Gabriela Canto, MD, PhD 3 and Dr. Miguel Dr. Laila Sabino Sabino Garro, MD, PhD 3, Prof. Jorge Kalil, MD, Blanca, MD, PhD6, 1Research Laboratory, Carlos Haya Hospital, PhD1, Prof. Antonio Ab ılio Motta, MD, PhD3 and Prof. Pedro Gia- Malaga, Spain, 2Laboratory for International Alliance on Ge- vina-Bianchi, MD, PhD, FAAAAI 1, 1Clinical Immunology and Al- nomic Research, RIKEN Center for Integrative Medical Sciences, lergy Division, University of Sao Paulo, Sao Paulo, Brazil, 2Clinical Yokohama Kanagawa, Japan, 3Allergy Service, Infanta Leonor Imunnology and Allergy Division, University of Sao Paulo, Sao Hospital, Madrid, Spain, 4Division of Rheumatology, Allergy paulo, Brazil, 3Clinical Imunnology and Allergy Division, Univer- and Immunology, Chang Gung Memorial Hospital at Lin-kou, sity of Sao Paulo, Sao Paulo, Brazil Kwei-san, Tao-yuan, Taiwan, 5Institute of Biomedical Sciences, 922 Prevalence Of Reported Penicillin Allergy In a Tertiary Allergy Academia Sinica, Taipei, Taiwan, 6Allergy Service, Carlos Immunology Clinic In The United States Haya Hospital, Malaga, Spain, 7Hospital De La Cruz Roja,, Ma- Dr. Sara M. May, MD , Andrew Nickels, MD and Dr. Michael drid, Spain, 8UMH Alicante G.University Hospital - Allergy Park, MD, FAAAAI, Mayo Clinic, Rochester, MN Sect., Alicante, Spain 923 Successful Oxacillin Desensitization With Interrupted Dosing 914 Tolerance To COX-2 Inhibitors In Children With Multiple Hy- Versus Continuous Infusion persensitivity To Non- Steroidal Anti-Inflammatory Drugs Dr. Melinda Braskett, MD , UCLA Med Center - Mattel Children’s Dr. Jose Luis Corzo Higueras, MD 1, Dr. Maria Angeles Zambo- Hospital, Los Angeles, CA and Dr. Monika Saeedian, MD, Univer- nino2, Dr. Candelaria Mu noz~ 1, Dr. Cristobalina Mayorga, PhD 3, sity of California, Los Angeles Dr. Gloria Requena 1, Dr. Antonio Urda 1, Dr. Miguel Blanca, MD, 924 IgE To Penicillins With Different Specificities Can Be Identified PhD4 and Dr. Maria J Torres, MD, PhD 4, 1Pediatric Service, Carlos By a Multiepitope Macromolecule. Bihaptenic Penicillin Struc- Haya Hospital, Malaga, Spain, 2Allergy Service, Carlos Haya Hos- tures and IgE Specificities 3 1 2 pital, Malaga, Spain, Malaga, Spain, Research Laboratory for Al- Dr. Adriana Ariza, PhD , Dr. Cristobalina Mayorga, PhD , Dr. TUESDAY lergic Diseases, Hospital Regional Universitario de Malaga - Maria Jose Jose Torres, MD, PhD 3, Dr. Maria Isabel Monta nez,~

145 AB356 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

PhD2, Dr. Ezequiel P erez-Inestrosa, PhD4, Dr. Antonio Jes us Ruiz- Gomez 7, Dr. Mabel Noemi Cuello, MD 8, Dr. Paola Toche Pinaud 9, Sanchez, PhD5, Dr. Rosa Mar ıa Rodr ıguez-Gueant, MD, PhD6, Dr. Dr. Blanca Maria Morfin-Maciel, MD 10 , Prof. Alicia De Falco 11 , Tah ıa Fern andez, PhD7, Dr. Jean Louis Gu eant6 and Dr. Miguel Dr. Adolfo Salvatierra 12 , Dr. Juan F. Schuhl, MD, FAAAAI 13 , Dr. Blanca, MD, PhD3, 1Research Laboratory for Allergic Diseases, Ivan Oswaldo Tinoco Moran, MD 14 , Dr. Susana Barayazarra 15 , Dr. Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Andrea Zanacchi15 , Prof. Ada Castillo M endez16 and Dr. Mario Malaga, Spain, 2Research Laboratory for Allergic Diseases, Hospi- Sanchez-Borges, MD, FAAAAI 17 , 1C.M.P. SA, Buenos Aires, Ar- tal Regional Universitario de Malaga - IBIMA, M alaga, Spain, 3Al- gentina, 2Universidad de Antioquia, Medellin, Colombia, 3Catholic lergy Service, Carlos Haya Hospital, Malaga, Spain, 4Andalusian University of Cordoba, Cordoba, Argentina, 4Universidade Federal Centre for Nanomedicine and Biotechnology, BIONAND, Malaga, de S ~ao Paulo, S ~ao Paulo, Brazil, 5Division of Immunology, Medical Spain, 5Andalusian Centre for Nanomedicine and Biotechnology- School, Universidad del Salvador, Buenos Aires. Head of the Divi- BIONAND, and Department of Organic Chemistry, Faculty of Sci- sion of Allergy and Immunology, Cl ınica Santa Isabel, Buenos Aires, ences, University of Malaga, M alaga, Spain, 6Laboratory of Cellu- Argentina, 6Hospital Universitario, Monterrey, Mexico, 7Hospital lar and Molecular Pathology in Nutrition, Faculty of Medicine, San Bernardo, Salta, Argentina, 8Consultorios San Juan, San Juan, University of Nancy, Nancy, France, 7Research Laboratory - FIMA- Argentina, 9Cl ınica Las Condes, Santiago, Chile, 10 Hospital Mocel, BIS Foundation, Malaga, Spain Mexico City, Mexico, 11 Universidad Nacional de La Plata, La Plata, 925 Cephalosporin Prescribing Habits In Penicillin Allergic Pa- Argentina, 12 Fundair, San Luis, Argentina, 13 British Hospital, Mon- tients tevideo, Uruguay, 14 Clinica Torre Medica Para La Familia, Machala, Dr. Shannon D. Tiedeken, MD , Nemours, A.I. duPont Hospital for Ecuador, 15 Nuevo Hospital San Roque, C ordoba, Argentina, 16 Hos- Children, Conshohocken, PA, Dr. Christopher Chang, MD, PhD, pital Clinico Quirurugico Dr. Salvador Allende, La Habana, Cuba, FAAAAI, Alfred I duPont Hospital for Children, Wilmington, DE 17 Clinica El Avila, 6a transversal Altamira, piso 8, consultorio 803, and Dr. Gang Ye, PhD, Nemours, Orlando, FL Caracas., Caracas, Venezuela 926 Radiocontrast Media Reactions: Rectifying Misconceptions 933 A New In Vitro Flow Cytometry Method For Detection Of De- About Shellfish Allergy and Iodine ‘‘Allergy’’ In An Academic layed Drug Sensitization To Local Anesthetics. The Lymphocyte Institution Activation Test (LAT) Dr. Amber N. Pepper, MD 1, Dr. Emma Westermann-Clark, MD, Dr. Massimo Caruso, PhD, FIT AAAAI , Dr. Rosalia Emma, Dr. MA 1, Dr. Neetu Talreja, MD 2 and Dr. Richard F. Lockey, MD 2, Raffaella Lizzio and Prof. Riccardo Polosa, MD, PhD, FAAAAI, 1Department of Internal Medicine, University of South Florida University of Catania, Catania, Italy Morsani College of Medicine, Tampa, FL, 2Division of Allergy 934 Utility Of ICD-9-CM Codes For Identification Of Allergic Drug and Immunology, Department of Internal Medicine, University of Reactions South Florida Morsani College of Medicine and James A. Haley Dr. Rebecca Saff, MD, PhD 1, Dr. Carlos Camargo Jr., MD, Veterans’ Affairs Hospital, Tampa, FL DrPH1,2, Dr. Susan A. Rudders, MD 3, Dr. Sunday Clark, MPH, 927 Clinical Predictors Of The Outcome Of Medication Challenges ScD4, Dr. Aidan Long, MD, FAAAAI 1 and Dr. Aleena Banerji, Dr. Farah Khan, DO 1,2, Dr. Christopher Chang, MD, PhD, MD 1, 1Division of Rheumatology, Allergy, and Immunology, De- FAAAAI 2 and Dr. Gang Ye, PhD 3, 1Thomas Jefferson University partment of Medicine, Massachusetts General Hospital, Harvard Hospital, Philadelphia, PA, 2Alfred I duPont Hospital for Children, Medical School, Boston, MA, 2Department of Emergency Medi- Wilmington, DE, 3Nemours, Orlando, FL cine, Massachusetts General Hospital, Harvard Medical School, 928 Clinical Experience With Oxaliplatin (O) Desensitization (OD): Boston, MA, 3Division of Asthma and Allergy, Department of Pe- A Case Series diatrics, Rhode Island Hospital, Alpert School of Medicine at Dr. Adam Updegraff, DO , University of South Florida, Tampa, FL Brown University, Providence, RI, 4Department of Emergency and Dr. Devang R. Doshi, MD, FAAAAI, William Beaumont Hos- Medicine, Weill Cornell Medical College, New York, NY pital, Royal Oak, MI 935 Vancomycin Use and Vancomycin Resistant Enterococcus Are 929 Clinical Value Of a Negative Skin Test To Contrast Radio Me- Increased In Patients With Reported Penicillin Allergy dia (CR) In Further Exposures Dr. Vinitha Reddy, MD , Penn State Hershey Medical Center, Her- Dr. Luiz C G Arcanjo , Dr. Tania M T Gonc¸alves, Flavia C Loyola, shey, PA and Dr. Faoud T. Ishmael, MD, PhD, FAAAAI, The Penn- Matheus Ribeiro, Alfredo Alves Neto, Tatiana L Carvalho and Dr. sylvania State University College of Medicine, Hershey, PA Jose Luiz M. Rios, MD, PhD, Policlinica Geral do Rio de Janeiro, Brazil 936 Detection Of Causative Drugs Using Measurement Of Inter- 930 Perioperative Reactions: Are They So Infrequent? feron- awith~ Quantiferon-TB Gold Test In Severe Drug Allergy: Dr. Claude M. Urbain, MD 1, Dr. Alberto Lafuente, MD 2, Dr. Gra- Preliminary Study cia Javaloyes, MD, PhD1, Dr. Paula Cabrera-Freitag, MD, PhD 3, Dr. Dr. Young-Hee Nam, MD 1, Dr. Kyeong-Hee Kim, MD 2, Dr. Dong Juan De La Borbolla Moran, MD 4, Dr. M Jose Goikoetxea, Ph.D, Sub Jeon, MD 3, Dr. Hye-Won Lee, MD 3, Hee-Joo Nam 4 and Mr. MD 4, Dr. Rafael Moncada, MD 2, Dr. Maria L Sanz, MD, PhD 1, Soo-Keol Lee, MD 5, 1Department of Internal Medicine, College Dr. Marta M. Ferrer, MD, PhD, FAAAAI 4 and Dr. Gabriel Gasta- of Medicine, Dong-A University, Busan, South Korea, 2Department 1 1

TUESDAY minza, MD, PhD , Department of Allergy, Clinica Universidad of Laboratory Medicine, College of Medicine, Dong-A University, de Navarra, Spain, 2Department of Anesthesia, Clinica Universidad South Korea, 3Department of Internal Medicine, College of Medi- de Navarra, Spain, 3Department of Allergy, Clinica Universidad de cine, Dong-A University, South Korea, 4Department of Pharmacy, Navarra, Spain, Pamplona, Spain, 4Department of Allergy, Clinica Dong-A University Hospital, South Korea, 5Dong-A University Universidad de Navarra, Pamplona, Spain College of Medicine, Pusan, South Korea 931 Causes Of Perioperative Allergic Reactions – Our Experience 937 Successful Rapid Desensitization To Glatiramer Acetate In a In The Last Two Years Patient With Multiple Sclerosis Dr. Lourdes Arochena, MD , Mrs. Deborah Hughes, RN, Dr. Dr. Ekaterini I. Syrigou, PhD , Department of Allergy, ‘‘Sotiria’’ Bryan N. Fernandes, MD, Dr. Marina Tsoumani, MD and Dr. Sus- General Hospital, Athens, Greece, Dr. Photis Psarros, Department ana F. Marinho, MD, PhD, University Hospital of South Manches- of Allergy, Athens Naval Hospital ,Greece and Prof. Konstantinos ter NHS Foundation Trust, Manchester, United Kingdom Syrigos, Athens School of Medicine, Greece 932 Perianesthetic Hypersensitivity Reactions In Latin America 938 Hypersensitivity Reaction To Denosumab In Patient With Oste- Dr. Edgardo J. Jares, MD 1, Dr. Ricardo Cardona-Villa, MD 2, Prof. oporosis: Desensitization Methodology Carlos E. Baena-Cagnani, MD 3, Dr. Luis Felipe C. Ensina, MD 4, Dr. Dr. Antonio Foncubierta, MD, PhD MPH 1,2, Dr. Diego Gutierrez, Juan C. Ivancevich, MD 5, Dr. Alfredo Arias Cruz 6, Dr. Maximiliano MD, PhD3, Dr. Fermin Medina, MD 3, Dr. Salvador Fernandez, MD,

146 J ALLERGY CLIN IMMUNOL Abstracts AB357 VOLUME 133, NUMBER 2

PhD4, Dr. Maria Jose Fernandez 3 and Dr. Juan Luis Anguita, MD 5, Hospital, Daegu, South Korea, 2Department of Internal Medicine,- 1Servicio Andaluz de Salud: UGC Joaquin Pece, 2Universidad de Kyungpook National University School of Medicine, Daegu, South Cadiz, 3Hospital Universitario Puerta del Mar, 4Hospital Universi- Korea, 3Department of Internal Medicine, Kyungpook National tario Carlos Haya, 5Complejo Hospitalario de Jaen University School of Medicine, Daegu, South Korea 939 Patient With Severe Primary Igf-I Deficit and Mecasermine Al- 949 Successful Rapid Induction Of Temporary Drug Tolerance To lergy: Desensitization Methodology Colistimethate Sodium Dr. Diego Gutierrez, MD, PhD 1, Dr. Antonio Foncubierta, MD, Dr. Colleen S. Adkins, MD , University of Alabama, Birmingham, PhD MPH2,3, Alfonso M. Lechuga, MD, PhD 1, Dr. Maria Jose Fer- AL and Dr. James Ryan Bonner, MD, FAAAAI, Alabama Allergy nandez1, Juan Luis Anguita,MD, PhD 4 and Jose Luis Lechuga, MD, & Asthma Center, Birmingham, AL PhD3, 1Hospital Universitario Puerta del Mar, 2Servicio Andaluz de 950 Anaphylactic Reaction During a Folfox Scheme Administration Salud: UGC Joaquin Pece, 3Universidad de Cadiz, 4Complejo Hos- Secondary To Calcium Folinate: A Case Report pitalario de Jaen Dr. Maria Alicia Urena Tavera, MD 1, Dr. Miriam Zamora Ver- 940 Drug-Induced Anaphylaxis: A Five Year Study In a Third Level duga1, Mrs. Denisse Angel Pereira 2, Dr. Ricardo Madrigal-Burga- Spanish Hospital leta, MD 1, Dr. Pilar Berges, MD. PhD. 1 and Dr. Emilio Alvarez- Maria Elisa Caralli, M.D.1, Sarah Micozzi, M.D. 1, Abdonias Cuesta1, 1Ramon y Cajal University Hospital, Spain, 2Ramon y Ca- Rodrıguez Gamboa, M.D. 1, Dasha Roa Medellin, M.D. 1, Alberto jal University Hospital, Madrid, Spain Alvarez-Perea, MD 2 and Manuel De Barrio, M.D. 1, 1Hospital Gen- 951 Dual Hypersensitivity To Oxaliplatin Revealed Following Rapid eral Universitario Gregorio Maran~on, Allergy Department, Madrid, Drug Desensitization: A History Of Anaphylaxis and New-Onset Spain, 2Hospital Materno Infantil Gregorio Maran~on, Pediatric Al- Hemolytic Anemia lergy Department, Madrid, Spain Dr. Jared Silver, MD, PhD 1, Dr. Timothy Kyin, MD 1 and Dr. Ma- 941 Quinolones Allergy In An Allergy Unit. Our Experience In 3 riana C. Castells, MD, PhD, FAAAAI 2, 1Brigham and Women’s Years Hospital, Boston, MA, 2Division of Rheumatology, Allergy and Im- Dr. Tamara Fernandez-Teruel 1, Gabriela Zambrano, M.D. 2, Celia munology, Department of Medicine, Brigham and Women’s Hospi- Pinto1, Beatriz Ameiro, M.D. 2, Dr. Roberto Pelta 1 and Manuel De tal, Harvard Medical School, Boston, MA Barrio1, 1Department of Allergy, Gregorio Mara n~on University 952 Oupatient Lenalidomide Desensitization For Delayed Hyper- Hospital, Madrid, Spain., 2Department of Allergy, Gregorio sensitivity Reactions In 5 Patients With Maran~on University Hospital, Madrid, Spain., Spain Dr. Min Jung Lee, MD 1, Dr. Paige G. Wickner, MD 2, Dr. Robert 942 A Successful Desensitization Protocol For Filgrastim Schlossman, MD 3, Dr. Paul Richardson, MD 3, Dr. Jacob Laubach, Brett Hronek, MD , Washington University School of Medicine, St MD 3 and Dr. Mariana C. Castells, MD, PhD, FAAAAI 4, 1Brigham Louis, MO and Anthony Kulczycki Jr., MD, FAAAAI, Washington & Women’s Hospital, Boston, MA, 2Brigham & Women’s Hospital, University School of Medicine, St. Louis, MO Chestnut Hill, MA, 3Dana Farber Cancer Institute, Boston, MA, 943 Are Proton Pump Inhibitors(PPI) Naive? A Case Of Drug Re- 4Division of Rheumatology, Allergy and Immunology, Department action With Eosinophilia and Systemic Symptom (DRESS) Sec- of Medicine, Brigham and Women’s Hospital, Harvard Medical ondary To Lansoprazole School, Boston, MA Dr. Aditya Uppalapati, MD 1, Dr. Sindhura Gogineni, MD 1, Dr. 953 An Atypical Case Of Drug Reaction With Eosinophilia and Sys- Sravantika Koneru, MBBS 2 and Dr. Ghassan Kamel, MD 3, 1St. temic Symptoms (DRESS) With Well-Formed Non-Necrotizing Louis University, St. Louis, MO, 2Mamata Medical College, 3Saint Granulomas On Bone Marrow Biopsy Louis University, St. Louis Dr. Katie Miro, MD , Rutgers- New Jersey Medical School, New- 944 Increased Of PCT and CRP In Dress Syndrome By Two Drugs ark, NJ and Dr. Eugenio Capitle, MD, Rutgers-New Jersey Medical Structurally Unrelated Molecular In The Same Pacient School, Newark, NJ Dr. Rafael A. Perez Arango , Ram on and Cajal University 954 Anaphylactic Reaction To Bacitracin Zinc Topical Antibiotic Hospital,Spain Ointment: A Case Report 945 Non-Immediate Skin Reactions Due To Antibiotics Dr. Jake D. Lenington, MD , Oregon Health and Science Univer- Gabriela Zambrano, M.D.1, Dr. Tamara Fernandez 2, Beatriz sity, Portland, OR, Dr. David R. Scott, MD, Allergy and Asthma Ameiro, M.D.1, Celia Pinto 3, Alberto Alvarez-Perea, MD 4 and Center of Western Colorado and Dr. Anthony Montanaro, MD, Manuel De Barrio, M.D. 5, 1Department of Allergy, Gregorio FAAAAI, Oregon Health Science University, Portland, OR Maran~on University Hospital, Madrid, Spain., Spain, 2Hospital gen- eral universitario gregorio mara non,~ Madrid, Spain, 3Department of Allergy, Gregorio Mara n~on University Hospital, Madrid, Spain., 4Hospital Materno Infantil Gregorio Maran~on, Pediatric Allergy Department, Madrid, Spain, 5Hospital General Universitario Gre- Ocular Allergy gorio Maran~on, Allergy Department, Madrid, Spain 946 Multiple Drug Hypersensitivity Syndrome In Our Allergy Ser- 5208 vice Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM Dr. Inmaculada Do na,~ MD, PhD, Dr. Maria J Torres, MD, PhD, 956 Ocular Surface Disease Index (OSDI) and Pollen Counts (PC) Dr. Paloma Campo, MD, PhD, Dr. Francisca G omez, MD, PhD, Mr. Spencer H. Luster , STARx Allergy and Asthma Center, Spring- Dr. Maria Salas, MD, PhD, Ms. Maria Dolores Ruiz, Ms. Maria field, NJ; University of Pennsylvania, Philadelphia, PA and Dr. Leo- Auxiliadora Guerrero and Dr. Miguel Blanca, MD, PhD, Allergy nard Bielory, MD, FAAAAI, Rutgers University, New Brunswick, Service, Carlos Haya Hospital, Malaga, Spain NJ; Robert Wood Johnson University Hospital, New Brunswick, NJ 947 Desensitization To Anakinra. Case Report 957 Efficacy and Safety Of a New Olopatadine Hydrochloride, Dr. Miriam Zamora Verduga , Dr. Maria Alicia Urena Tavera, 0.77% Ophthalmic Formulation In Patients With Allergic Con- Mrs. Denisse Angel Pereira, Dr. Ricardo Madrigal-Burgaleta, junctivitis Using The Conjunctival Allergen Challenge (CAC) MD, Dr. Pilar Berges-Gimeno, PhD and Dr. Emilio Alvarez-Cuesta, Model (NCT01479374) MD, PhD, Ramon y Cajal University Hospital, Madrid, Spain Gail Torkildsen , Andover Eye Associates, Andover, MA, Thomas 948 Vitamin K Anaphylaxis Confirmed With Skin Test Macejko, Apex Eye, Fairfield, OH, Abhijit Narvekar, Alcon Labo- 1,2 1,3 1 Dr. Min-Hye Kim and Dr. Jong-Myung Lee, MD , Regional ratories, Inc., Fort Worth, TX and Mark Bergmann, Apex Eye, Cin- TUESDAY Pharmacovigilance Center, Kyungpook National University cinnati, OH

147 AB358 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

958 Cytokine Secretion Profiles In The Tears Of Patients With MD, FAAAAI 2, 1Hackensack University Medical Center, Hacken- Chronic Allergic Conjunctivitis sack, NJ, 2Center for Allergy, Asthma and Immune Disorders Hack- Dr. Naoko Okada 1, Dr. Hiroshi Fujishima 2, Dr. Kazumi Fukagawa 3, ensack University Medical Center, Hackensack, NJ Dr. Akio Matsuda, PhD 1, Dr. Hirohisa Saito, MD., PhD. 1 and Dr. 966 Nanoparticle Engineering For The Immunomodulation Of Den- Kenji Matsumoto, MD, PhD 1, 1Department of Allergy and Immunol- dritic Cells ogy, National Research Institute for Child Health and Development, Dr. Xavier le Guevel, PhD 1, Dr. Tah ıa Fern andez, PhD2, Dr. Adri- Tokyo, Japan, 2Department of Ophthalmology, Tsurumi University, ana Ariza, PhD3, Dr. Maria Isabel Monta nez,~ PhD4, Dr. Maria J 3Department of Ophthalmology, Keio University School of Medicine Torres, MD, PhD 5, Dr. Cristobalina Mayorga, PhD 6 and Dr. Miguel 959 Severity and Frequency Of Allergic Conjunctivitis Symptoms Blanca, MD, PhD5, 1Bionand, Campanillas, Spain, 2Research Lab- Dr. M. Hom, OD FAAO , Private Practice, Azusa, CA, Dr. oratory - FIMABIS Foundation, M alaga, Spain, 3Research Labora- Dominick Opitz, OD FAAO, Illinois College of Optometry, Chi- tory for Allergic Diseases, Hospital Regional Universitario de cago, IL, Dr. Justin Kwan, OD FAAO, Marshall B. Ketchum Uni- Malaga - FIMABIS-IBIMA, Malaga, Spain, 4Research Laboratory versity, Fullerton, CA and Dr. Leonard Bielory, MD, FAAAAI, for Allergic Diseases, Hospital Regional Universitario de Malaga Robert Wood Johnson University Hospital, New Brunswick, NJ; - IBIMA, M alaga, Spain, 5Allergy Service, Carlos Haya Hospital, Rutgers University, New Brunswick, NJ Malaga, Spain, 6Research Laboratory, Carlos Haya Hospital-FIMA- 960 Ocular Symptoms Are Proportionally More Bothersome In BIS, Malaga, Spain Subjects With More Symptoms Of Cat Allergic Rhinoconjunc- 967 Specific Immunotherapy Modified T-Cells Responses In a Span- tivitis ish Population Of Der p Allergic Patients Dr. Peter Creticos, Associate Professor of Medicine; Johns Hop- Dr. Tah ıa Fern andez, PhD1, Dr. Cristobalina Mayorga, PhD 2, Dr. kins School of Medicine , Johns Hopkins School of Medicine; Di- Enrique Gomez3, Mrs. Rosa Garcia 4, Mrs. Maria Isabel Sanchez 5, vision of Allergy & Clinical Immunology, Crownsville, MD, Dr. Dr. Ana Aranda, PhD 2, Ms. Miriam Osorio 2, Dr. Miguel Blanca, Stephen Durham, co-author, Imperial College, London, Dr. Mar- MD, PhD6 and Dr. Mar ıa Jos e Torres, MD, PhD 6, 1Research Labo- garet Maclennan, co-author, InVentiv Health and Dr. Rod Hafner, ratory - FIMABIS Foundation, M alaga, Spain, 2Research Labora- PhD, Circassia Ltd, Oxford, United Kingdom tory, Carlos Haya Hospital-FIMABIS, M alaga, Spain, 3Research 961 Alcaftadine 0.25% Versus Olopatadine 0.2% In Prevention Of Laboratory of allergic diseases - Carlos Haya Hospital. FIMABIS Ocular Itching In Allergic Conjunctivitis Foundation. Spain, Malaga, Spain, 4Allergy Service- Carlos Haya Eugene B. McLaurin, MD, FACS 1, Nicholas P. Marsico, MD, hospital. Spain, Malaga, Spain, 5Allergy Service -Carlos Haya Hos- FACS 2, Joseph B. Ciolino, MD 3, Linda Villanueva, COT 4, Julia pital. Spain, 6Allergy Service, Carlos Haya Hospital, M alaga, Spain M. Williams, MA, BS 4 and David A. Hollander, MD, MBA 4, 1Total 968 Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In Grass Eye Care P.A., Memphis, TN, 2East West Eye Institute, Los An- Pollen-Associated Allergic Rhinoconjunctivitis: Pooled Analysis geles, CA, 3Massachusetts Eye & Ear Infirmary, Harvard Medical By Level Of Pollen Exposure School, Boston, MA, 4Allergan, Inc., Irvine, CA Prof. Alain Didier, MD, PhD 1, Prof. Ulrich Wahn, Prof Dr Med 2, 962 Cetirizine Significantly Relieves Ocular Allergy Symptoms In Mr. Yann Amistani, Msc 3 and Dr. Robert K. Zeldin, MD 3, 1Larrey Subjects With Seasonal Allergic Rhinitis Hospital, CHU, Toulouse, France, 2Charite, Berlin, Germany, 3Stal- Dr. Mitesh Patel, PharmD 1, Dr. Eduardo Urdaneta, MD 1, Ms. lergenes S.A., Antony, France Kathleen B. Franklin, BSN, RN 2, Ms. Xiaoyan Tian, MS 3, Dr. Mei- 969 The Print Survey II: Perceptions Regarding Injection Number Miau Wu, Dr PH 4 and Ms. Qiong Du, MS 3, 1McNeil Consumer and Technique Healthcare, Fort Washington, PA, 2Franklin Consultants, LLC., Phoe- Dr. Michael S. Tankersley, MD, FAAAAI 1, Dr. Sandy Yip, MD 2 nixville, PA, 3Johnson & Johnson Consumer Products, China, Shang- and Dr. Christopher A. Coop, MD 2, 1Wilford Hall Ambulatory Sur- hai, China, 4J & J Consumer Products, US, Morris Plains, NJ gical Center, Joint Base San Antonio, San Antonio, TX, 2Wilford 963 Cetirizine Effectively Relieves Both Ocular Allergy Symptoms Hall Ambulatory Surgical Center, Lackland AFB, TX and Nasal Allergy Symptoms In Subjects With Seasonal Aller- 970 Allergy Immunotherapy: Characteristics and Risk Factors For gic Rhinitis Recurrent Systemic Reactions Dr. Eduardo Urdaneta, MD 1, Ms. Xiaoyan Tian, MS 2, Dr. Mei- Kerline Ductan, MD 1, Ewa Schafer, MD, FAAAAI 2, Rachel E. Miau Wu, Dr PH 3, Ms. Qiong Du, MS 2, Ms. Kathleen B. Franklin, Story, MD 2, Deeba Masood, MD 2, Paul Detjen, MD 3 and Ying BSN, RN 4 and Dr. Mitesh Patel, PharmD 1, 1McNeil Consumer Zhou, PhD4, 1Department of Internal Medicine, University of Chi- Healthcare, Fort Washington, PA, 2Johnson & Johnson Consumer cago-NorthShore, Evanston, IL, 2Allergy and Immunology, North- Products, China, Shanghai, China, 3J & J Consumer Products, US, Shore University HealthSystem (NUHS), IL, 3Kenilworth Medical Morris Plains, NJ, 4Franklin Consultants, LLC., Phoenixville, PA Allergy & Immunology, Kenilworth, IL, 4Center for Clinical and 964 Automated Evaluation Of Conjunctival Provocation Tests Research Informatics (CCRI), NUHS Research Institute, Evanston, Mr. Torsten Sehlinger 1, Mr. Jaron Zuberbier 2, Dr. Oliver Kueh- IL lert1, Mr. Frank Goergen 1, Prof. Torsten Zuberbier 3 and Prof. 971 Allergen Specific Immunotherapy In Monosensitized and Poly- 3 1

TUESDAY Karl-Christian Bergmann , Bluestone Technology GmbH, Woerr- sensitized Allergic Rhinitis Patients stadt, Germany, 2Evangelic High-School Kleinmachnow, Germany, Dr. L. Maslova , Republican Scientific and Practical Center for Ep- 3Allergy-Centre-Charite, Berlin, Germany idemiology and Microbiology.Minsk, Belarus, Dr. Leonid P. Titov, MD, PhD, Republican Scientific and Practical Center for Epidemi- ology and Microbiology, Minsk, Belarus and Prof. Lawrence M. DuBuske, MD, FAAAAI, George Washington University School of Medicine, DC Allergen Immunotherapy 972 The Effect Of The Ragweed Sublingual Immunotherapy Tablet MK-3641 On Rescue Medication Use 5209 Dr. Sandra M. Gawchik, DO, FAAAAI 1, Dr. Peter S. Creticos, MD, Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM FAAAAI 2, Kevin R. Murphy, MD 3, Dr. Gary D. Berman, MD, 965 Aeroallergen Immunotherapy Reduces Wheal Diameter In Sea- FAAAAI 4, Dr. David I. Bernstein, MD, FAAAAI 5, Dr. Jennifer Ma- sonal and Perennial Allergen Intradermal Skin Tests loney, MD 6, Dr. Amarjot Kaur, PhD 6 and Dr. Hendrik Nolte, MD, Mr. Michael Hauk 1, Mrs. Barbara A. McGoey, RN 1, Mr. Parimal PhD6, 1Asthma and Allergy Associates, Chester, PA, 2Johns Hopkins Patel 1, Mrs. Nicole Argenzia, RN 1 and Dr. Mary Ann Michelis, Division of Allergy & Clinical Immunology, 3Boys Town National

148 J ALLERGY CLIN IMMUNOL Abstracts AB359 VOLUME 133, NUMBER 2

Research Hospital, Boys Town, NE, 4Allergy and Asthma Special- Basic and Translational Immunology ists, Minneapolis, MN, 5Bernstein Allergy Group, Cincinnati, OH, 6 Merck, Whitehouse Station, NJ 5602 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 978 Novel NK Cytotoxicity Assay Enables Drug Discovery For He- mophagocytic Lymphohistiocytosis Dr. Jinzhu Li, MD, PhD , Ms. Sarah E. Figueira, Ms. Julie Ferrel Asthma Epidemiology and Risk Factors and Dr. Kimberly A. Risma, MD, PhD, FAAAAI, Cincinnati Chil- dren’s Hospital Medical Center, Cincinnati, OH 5601 979 Exploitation Of The Host Ubiquitin System By Respiratory Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM Syncytial Virus Nonstructural Protein 2 Jillian N. Whelan 1, Kim C. Tran 1, Ruan R. Cox Jr. 1, Damian B. 973 Exposures That Alter The Early Life Microbiome and The Risk van Rossum 2, Randen L. Patterson 2 and Michael Teng 1, 1Division Of Asthma of Allergy and Immunology, Department of Internal Medicine, Amy S. Feldman, MD 1, Pingsheng Wu, PhD, MS 1,2, Kristina and the Joy McCann Culverhouse Airway Diseases Research Cen- James, MD 3, Tebeb Gebretsadik, MPH 1,2, Gabriel Escobar, ter, University of South Florida Morsani College of Medicine, MD 4,5, Kecia N. Carroll, MD 6, Sherian Xu Li, MS 5, Eileen Tampa, FL, 2The Pennsylvania State University, University Walsh, RN, MPH 5, Ed Mitchel, MS 1 and Dr. Tina V. Hartert, Park, PA MD, MPH7, 1Division of Allergy, Pulmonary, and Critical Care 980 Epigenetic Regulation Of Dendritic Cell Migration Medicine, Department of Medicine, and Center for Asthma and Dr. Timothy P. Moran, MD, PhD 1, Dr. Hideki Nakano, PhD 2, Dr. Environmental Sciences Research, Vanderbilt University School Hrisavgi Kondilis-Mangum, PhD 2, Dr. Paul Wade, PhD 2 and Dr. of Medicine, Nashville, TN, 2Department of Biostatistics, Van- Donald Cook, PhD2, 1Duke University Medical Center, Durham, derbilt University School of Medicine, Nashville, TN, 3Peninsula NC, 2National Institute of Environmental Health Sciences, NIH, Allergy & Asthma Center, Soldotna, AK, 4Kaiser Permanente Research Triangle Park, NC Medical Care Program, Oakland, CA, 5Kaiser Permanente North- 981 LRBA Subcellular Localization: Evidence Of The LRBA’s Role ern California, Perinatal Research Unit, Division of Research, In Vesicle Trafficking From The Golgi To Cell Membrane and 6Department of Pediatrics, Vanderbilt University School of Med- Endocytosis icine, Nashville, TN, 7Vanderbilt University School of Medicine, Mrs. Michelle A. Reiser, MS 1, Dr. Jia-Wang Wang, PhD 1, Mrs. Nashville, TN Kunyu Li, BS 1 and Dr. Richard F. Lockey, MD 2, 1Division of Al- 974 Ethnic Differences Of Reported Asthma Symptoms In Urban lergy and Immunology, Department of Internal Medicine, Univer- School-Based Screening Surveys sity of South Florida, Morsani College of Medicine, Tampa, FL, Dr. Margee Louisias, MD 1, Dr. Joanne Sordillo, ScD 2,3, Mrs. 2Division of Allergy and Immunology, Department of Internal Chunxia Fu, MS 4,5 and Dr. Wanda Phipatanakul, MD, MS, Medicine, University of South Florida Morsani College of Medi- FAAAAI 3,6, 1Brigham and Women’s Hospital, Boston, MA, 2Chan- cine and James A. Haley Veterans’ Affairs Hospital, Tampa, FL ning Division of Network Medicine, Brigham & Women’s Hospital, 982 Differential Role Of Dendritic Cell Subsets In Shaping T-Cell Harvard Medical School, Boston, MA, 3Harvard Medical School, Responses To Respiratory Viruses Boston, MA, 4Harvard School of Public Health, Boston, MA, Dr. Meera Rani Gupta, M.D. , Dr. Deepthi Kolli, PhD, Dr. Anto- 5Channing Laboratory, Brigham and Women’s Hospital, Boston, nella Casola, M.D. and Dr. Roberto P. Garofalo, MD, University MA, 6Boston Children’s Hospital, Boston, MA of Texas Medical Branch, Galveston, TX 975 Year One Daycare Attendance Predicts Asthma At Age Seven: The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) Dr. Gang Cheng, MD, PhD 1, Linda Levin, PhD 2, Dr. Andrew M. Smith, MD, FAAAAI 3, Dr. Tolly Epstein, MD, MS 4, Patrick Ryan, Environmental Risk Factors and Diseases PhD5, Grace K. LeMasters, PhD 2 and Dr. David I. Bernstein, MD, FAAAAI 1, 1Division of Immunology Allergy & Rheumatology, Outcomes University of Cincinnati Medical Center, CINCINNATI, OH, 2Uni- versity of Cincinnati, Cincinnati, OH, 33255 Eden Ave., HPB 350, 5603 University of Cincinnati Medical Center, Cincinnati, OH, 4Allergy Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM Partners of Central Indiana, Indianapolis, IN, 5Cincinnati Children’s 983 Effect Of Prenatal Exposure To Indoor PM2.5 and Environ- Hospital, Cincinnati, OH mental Tobacco Smoke Affecting Lower Respiratory Tract In- 976 Determining Risk Levels Of The Composite Asthma Severity fection Was Modified By ROS Genes: Cocoa Study Index (CASI) Dr. Song I Yang, MD 1, Dr. Eun Lee, MD 1, Dr. Young Ho Jung, Rebecca A. Zabel 1, Dr. Peter J. Gergen, MD, MPH 2, Dr. Christine MD 1, Kil-Yong Choi 2, Mi-Jin Kang, MS 2, Ho-Sung Yu 2, Cheol A. Sorkness, PharmD 3, Jeremy Wildfire 1, Mr. Agustin Calatroni, Min Lee3, Prof. Youn Ho Shin, MD, PhD 4, Prof. Kangmo Ahn, MA MS 1 and Dr. Herman Mitchell, PhD 1, 1Rho, Inc., Chapel MD, PhD5, Prof. Kyung Won Kim, MD, PhD 6, Prof. Soo-Jong Hill, NC, 2AAIB\DAIT\NIH, Bethesda, MD, 3University of Wis- Hong, MD, PhD1 and Cocoa study Group7, 1Childhood Asthma At- consin, Madison, WI opy Center, Department of Pediatrics, Asan Medical Center, Uni- 977 BMI and Asthma Severity In An Elementary and Middle versity of Ulsan College of Medicine, Seoul, South Korea, 2Asan School Inner City Population Institute for Life Sciences, University of Ulsan College of Medi- Dr. Christina G. Kwong, MD 1, Ms. Christina Mahl, RN 2, Ms. Lisa cine, Seoul, South Korea, 3Institute of Environmental and Industrial D. Henry, PNP-BC 2, Dr. Deborah Loman, PhD, CPNP 3, Dr. Robert Medicine, Hanyang University, Seoul, South Korea, 4Department of C. Strunk IV, MD, FAAAAI 1, Ms. Lisa A. Meadows, PNP-BC 2 and Pediatrics, CHA Medical Center, CHA University College of Med- Dr. Alysa G. Ellis, MD 1, 1Washington University School of icine, Seoul, South Korea, 5Department of Pediatrics, Samsung Medicine, Saint Louis, MO, 2St. Louis Children’s Hospital, Medical Center, Sungkyunkwan University School of Medicine,

Saint Louis, MO, 3St. Louis University School of Nursing, Saint Seoul, South Korea, 6Department of Pediatrics, Yonsei University TUESDAY Louis, MO College of Medicine, Seoul, South Korea, 7COCOA study group

149 AB360 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

984 IgE Anti-Respiratory Syncytial Virus Antibodies In Older Asth- 990 Development Of Eosinophilic Esophagitis To Food After Devel- matic Children opment Of IgE Tolerance To The Same Food Mira Mandal 1, Dr. Rauno O. Joks, MD, FAAAAI 2, Dr. Kevin Noro- Dr. Solrun Melkorka Maggadottir, MD 1, Dr. David Hill, MD, witz, M.D. 3, Dr. Diana Weaver, MD 4, Dr. Helen G. Durkin, PhD 5, Dr. PhD2, Dr. Terri F. Brown-Whitehorn, MD 1 and Dr. Jonathan M. Martin H. Bluth, MD, PhD 6, Dr. Stephan Kohlhoff, MD 5 and Dr. Tamar Spergel, MD, PhD, FAAAAI 3, 1Children’s Hospital of Philadelphia, A. Smith-Norowitz, PhD 7, 1SUNY Downstate Medical Center, Philadelphia, PA, 2Childrens Hospital of Philadelphia, 3The Chil- 2SUNY-HSC, Brooklyn, NY, 3SUNY Downstate Medical Center, Cen- dren’s Hospital of Philadelphia, Philadelphia, PA ter for Allergy and Asthma Research, Brooklyn, NY, 4SUNY Down- 991 Mast Cells, Eosinophils and Eosinophilic Esophagitis state Med. Ctr, Brooklyn, NY, 5Center for Allergy and Asthma Dr. Jay Jin, MD, PhD , Dr. Jeffrey Alexander, MD, Hirohito Kita, Research, State University of New York Downstate Medical Center, MD, Ms. Diane Squillace, MS, Dr. Joseph A. Murray, MD, Dr. Brooklyn, NY, 6Wayne State University Medicine, Detroit, MI, 7Center Amindra Arora, MD, Dr. Yvonne Romero, MD, Dr. Thomas for Allergy and Asthma Research at SUNY Downstate, Brooklyn, NY Smyrk, MD and Dr. Catherine R. Weiler, MD, PhD, FAAAAI, 985 Asthma Symptoms and Rhinovirus In A Longitudinal Chil- Mayo Clinic, Rochester, MN dren’s Cohort 992 CD3 and CD8 Cells Produce IL-9 In Pediatric Eosinophilic Dr. Euan R. Tovey, PhD 1,2 , Dr. S. Stelzer-Braid, PhD 3,4 , Dr. B.G. Esophagitis Toelle, PhD 1, Ms. C.M. Willenborg, BSc 3, Dr. H.K Reddel, PhD, Arjun Andrew Anilkumar, BS , Department of Medicine; Division MBBS 1,2 , Ms. F.L. Garden, MPH 1,2 , Prof. A. Jaffe, PhD MD 4,5 , Ms. of Allergy/Immunology, Lisa Beppu, BS, Department of Pediatrics R. Strachan 5, Dr. B.G. Oliver, PhD 1,2 , Dr. Y.C. Belessis, MBBS 4,5 , University of California San Diego; Division of Allergy and Immu- Prof. G.B. Marks, PhD, MD 1,2 and Prof. W.D. Rawlinson, PhD, nology, Richard Kurten, PhD, University of Arkansas for Medical MD 3,4 , 1Woolcock Institute of Medical Research, Sydney, Australia, Sciences, Little Rock, AR; Department of Physiology and Biophys- 2University of Sydney, Australia, 3Virology Division, SEALS Micro- ics, Dr. Robert Newbury, MD, Department of Pediatrics; Division of biology, Prince of Wales Hospital, Sydney, Australia, 4University of Pathology, Ranjan Dohil, MD, Department of Pediatrics, Division of NSW, Australia, 5Sydney Children’s Hospital, Randwick Australia Gastroenterology; Division of Gastroenterology, UCSD, Rady Chil- 986 Maternal Transfer Of Der p 1 and Blo t 5 Allergens and Their dren’s Hospital, San Diego, David Broide, MB ChB, University of Respective Specific Antibodies Trough Placenta and Colostrum California San Diego, Department of Medicine, Division of Allergy Dr. Patricia Macchiaverni , Department of Immunology, Institute and Immunology and Seema Sharma Aceves, MD, PhD, FAAAAI, of Biomedical Sciences, University of S ~ao Paulo, SP, Brazil, Chris- Pediatrics, University of California San Diego, La Jolla, CA tina Arslanian, University of S ~ao Paulo, Dr. Valerie Verhasselt, IN- SERM, Valbonne, France and Prof. Antonio Condino-Neto, MD, PhD, Institute of Biomedical Sciences, Department of Immunology, University of S ~ao Paulo, Sao Paulo, Brazil 987 Rhinovirus Infection Is Associated With Changes In The Air- way Microbiome Population Health and Food Allergy Dr. Kirsten Kloepfer, MD 1, Dr. Valeriy Poroyko, PhD 2, Mrs. Rose Vrtis, BS 3, Mrs. Tressa Pappas, BS 3, Dr. Theresa Kang, PhD 3, Dr. 5605 Wai-Ming Lee, PhD 3, Mr. Michael D. Evans, MS 3, Dr. Ronald E. Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM Gangnon, PhD3, Dr. Yury Bochkov, PhD 3, Dr. Robert F. Lemanske 993 Longitudinal Effect Of Food Allergy Education On Epineph- Jr., MD, FAAAAI 3 and Dr. James E. Gern, MD, FAAAAI 3, 1Riley rine Availability In Public Schools Dipika Patel, MD 1, Gwendo- Hospital for Children at Indiana University Health, Indianapolis, lyn Johnson, BSN, RN, MEd2, Danielle Guffey, MS 1, Charles IN, 2University of Chicago, Chicago, IL, 3University of Wisconsin Minard, PhD1 and Carla Davis, MD 1, 1Baylor College of Medicine, School of Medicine and Public Health, Madison, WI Houston, TX, 2Houston Independent School District, Houston, TX 994 Population Response To Change In Infant Feeding Guidelines For Allergy Prevention Dr. Dean Tey, MD 1,2, Prof. Katrina Jane Allen, MD, PhD, Eosinophilic Gastrointestinal Diseases FAAAAI 1,2, Ms. Rachel Peters, MPH 2, Dr. Jennifer Koplin, PhD 2, Prof. Mimi L. K. Tang, MD, PhD, FAAAAI 3, Prof. Lyle Gurrin, 5604 PhD2,4, Prof. Anne-Louise Ponsonby, PhD 2, Dr. Adrian Lowe, Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM PhD2,4, Prof. Melissa Wake, MD, PhD 1,2 and Prof. Shyamali Dhar- 988 Natural History Of Esophageal Remodeling In Pediatric Eosin- mage, MD, PhD2,4, 1Royal Children’s Hospital, Victoria, Australia, ophilic Esophagitis Treated For Four Years 2Murdoch Childrens Research Institute, Victoria, Australia, 3The Dr.Jessica Rajan, MD 1,2 , Dr. Robert Newbury, MD 3,4 , Arjun Andrew University of Melbourne, Melbourne, Australia, 4University of Anilkumar, BS 2,5 , Ranjan Dohil, MD 6,7 , Dr. David H. Broide, MB ChB Melbourne, Victoria, Australia 8 9 1

TUESDAY FAAAAI and Seema Sharma Aceves, MD, PhD, FAAAAI , Scripps 995 Teasing and Bullying Among Adolescents With Food Allergy Clinic Medical Group, San Diego, CA, 2Division of Allergy/Immunol- Dr. Adora Lin, MD, PhD , National Institute of Allergy and Infec- ogy, 3Department of Pediatrics, 4Division of Pathology, 5Department tious Diseases, Bethesda, MD and Dr. Hemant P. Sharma, MD MHS of Medicine, 6Department of Pediatrics, Division of Gastroenterology, FAAAAI, Children’s National Medical Center, Division of Allergy 7Division of Gastroenterology, UCSD, Rady Children’s Hospital, San and Immunology, Washington, DC Diego, 8Department of Medicine, San Diego, CA, 9Pediatrics, Univer- 996 Differences In Food Allergy Quality Of Life Between Care- sity of California San Diego, La Jolla, CA givers In a Clinic-Based and a Caregiver-Reported Food Aller- 989 Diagnostic Inaccuracy Of Biopsy Evaluations In Eosinophilic gic Population Esophagitis Underscores The Value Of a Secondary Review Dr. Matthew J. Greenhawt, MD, MBA, MSc , Department of In- Process ternal Medicine, The University of Michigan Medical School, Divi- Emily Stucke, BA 1, Dr. Katherine E. Clarridge, MD, MSc 1,2, Dr. sion of Allergy and Clinical Immunology, Ann Arbor, MI Margaret Collins, MD 1, Dr. Lisa J. Martin, PhD 1, Carol J. Hender- 997 Food Allergy Management In An Urban Pediatric Population son, PhD RD LD 1 and Dr. Marc E. Rothenberg, MD, PhD, Dr. Jennifer M. Camacho, MD , Dr. Stephanie Albin, MD, Dr. FAAAAI 1, 1Cincinnati Children’s Hospital Medical Center, Cincin- Doerthe A. Andreae, MD and Dr. Julie Wang, MD, FAAAAI, nati, OH, 2University of Cincinnati The Icahn School of Medicine at Mount Sinai, New York, NY

150 J ALLERGY CLIN IMMUNOL Abstracts AB361 VOLUME 133, NUMBER 2

New Forms of Immunotherapy Parronchi 1, 1University of Florence, DENOTHE Center, Florence, Italy, 2University of Florence, Dept. of Chemistry ‘‘U. Shiff’’, 3 5606 Florence, Italy, University of Florence, Mass Spectrometry Cen- Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM ter (CISM), Florence, Italy 998 Persistent Treatment Effect Achieved At One Year After Four Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Epitopes In An Exposure Chamber Model Of House Dust Mite Allergy Dr. Rod Hafner, PhD 1, Dr. Peter Couroux, M.D. 2, Ms. Kristen Mechanisms of T Cell-Mediated Allergic Disease Armstrong, M.Sc.3, Dr. AnneMarie Salapatek, PhD 4, Dr. Deepen Patel, M.D.2 and Dr. Mark Larche, PhD 5, 1Circassia Ltd, Oxford, 5607 United Kingdom, 2Topstone Research, Toronto, ON, Canada, Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 3Adiga Life Sciences Inc., Hamilton, ON, Canada, 4Inflamax Re- 1003 TSLP Induces Corticosteroid Resistance In Natural Helper search, Mississauga, ON, Canada, 5McMaster University/St. Jo- Cells Via STAT5 Pathway seph’s Healthcare, Hamilton, ON, Canada Hiroki Kabata1, Kazuyo Moro 2,3, Koichi Fukunaga 1, Yusuke Su- 999 Treatment With Synthetic Peptide Immuno-Regulatory Epi- zuki1, Katsunori Masaki 1, Tomoko Betsuyaku 1, Shigeo Koyasu 1,2 topes Derived From Grass Allergens Leads To a Substantial Re- and Prof. Koichiro Asano, MD 4, 1Keio University School of Med- duction In Grass Allergy Symptoms In The Environmental icine, Tokyo, Japan, 2RIKEN Center for Integrative Medical Sci- Exposure Unit ences, Kanagawa, Japan, 3PRESTO, JST, Japan, 4Tokai Dr. Anne K. Ellis, MD, MSc FAAAAI 1,2, Dr. Charles W. Frankish, University School of Medicine, Kanagawa, Japan MD 3, Ms. Kristen Armstrong, M.Sc. 4, Dr. Mark Larche, PhD 5, Ms. 1004 Impairment Of IL-27’s Differential Effect On CD4+T Cells In Lisa Steacy, BSc 1 and Dr. Rod Hafner, PhD 6, 1Allergy Research Asthma Unit, Kingston General Hospital, Kingston, ON, Canada, 2Depart- Dr. Zhihong Chen 1, Shanze Wang 2, Xiaopeng Qi 2, Prof. Chunxue ments of Medicine and Biomedical & Molecular Science, Queen’s Bai1 and Prof. Hua Huang2, 1Zhongshan Hospital, Fudan Univer- University, Kingston, ON, Canada, 3Kanata Allergy Services, Ka- sity, Shanghai, China, 2National Jewish Health, Denver, CO nata, ON, Canada, 4Adiga Life Sciences Inc., Hamilton, ON, Can- 1005 Profile Of Food Allergen-Specific T Cells In Allergic and Clin- ada, 5McMaster University/St. Joseph’s Healthcare, Hamilton, ON, ically Tolerant Individuals Canada, 6Circassia, Oxford, United Kingdom David Chiang, MS 1, Alexander V. Grishin, PhD 1, Madhan Masi- 1000 Epicutaneous Immunotherapy Induces Epigenetic Changes In lamani, PhD1, Miriam Merad, MD, PhD 1, A. Karolina Palucka, Sensitized Mice MD, PhD1,2, Hideki Ueno, MD, PhD 2, A. Wesley Burks, MD, Lucie Mondoulet, PhD1, Dr. Vincent Dioszeghy, PhD 1, Mrs. FAAAAI 3, Stacie M. Jones, MD 4, Andrew H. Liu, MD 5, Scott Melanie Ligouis1, Mrs. V eronique Dhelft1, Mrs. Emilie Puteaux 1, H. Sicherer, MD, FAAAAI 1, Robert A. Wood, MD, FAAAAI 6, Mrs. Camille Plaquet1, Prof. Christophe Dupont, MD, PhD 2 and Wendy Davidson, PhD 7, Hugh A. Sampson, MD, FAAAAI 8 and Pierre Henri Benhamou, MD 1, 1DBV Technologies, Bagneux, M. Cecilia Berin, PhD 1, 1Icahn School of Medicine at Mount Si- France, 2Hopital Necker Enfants Malades, Paris, France nai, New York, NY, 2Baylor Institute for Immunology Research, 1001 Ultra-Fast Hypoallergenic Birch Pollen Allergy Vaccine Allert Dallas, TX, 3University of North Carolina, Chapel Hill, NC, 4Uni- Is Efficient and Safe: Results Of a Phase IIb Study versity of Arkansas for Medical Sciences and Arkansas Children’s Dr. Francois Spertini, MD 1, Prof. Frederic de BLAY 2, Dr. Lars Hospital, Little Rock, AR, 5National Jewish Health, Denver, CO, Jacobsen, MD 3, Prof. Marek Jutel, MD, PhD 4, Dr. Margitta 6Johns Hopkins University Medical Center, Baltimore, MD, 7Na- Worm, MD 5, Dr. Gilles Della Corte, MD 6, Dr. Alexander Kettner, tional Institutes of Health, Bethesda, MD, 8Pediatrics, Icahn PhD7, Dr. Vincent Charlon, PhD 6 and Dr. Christophe Reymond 7, School of Medicine at Mount Sinai, New York, NY 1Division of Immunology and Allergy, CHUV, LAUSANNE, 1006 Follicular Helper T Cells Mediate IgE Antibody Production Switzerland, 2CHRU Strasbourg, France, 3Glostrup University and Allergic Immune Responses in Mice Hospital, Copenhagen, Denmark, 4Wroclaw Medical University, Takao Kobayashi, PhD 1, Koji Iijima, PhD 1 and Hirohito Kita, Wroclaw, Poland, 5Charite - Universit €atsmedizin Berlin, Berlin, MD 2, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic Rochester, Ro- Germany, 6Anergis SA, Epalinges, Switzerland, 7ANERGIS SA, chester, MN EPALINGES, Switzerland 1007 Analysis Of Circulating Rhinovirus-Specific CD4+ T Cells Us- 1002 Stable Conjugates Between A Novel Toll-Like Receptor 7 Lig- ing Novel MHC Class II Tetramers Reveals Marked Expan- and and Protein Allergens As Modulators Of Th2 Responses sion Of Effector Memory Cells In Infected Subjects In Vitro and In Vivo Lyndsey Muehling 1, Rachana Agrawal, PhD 1, Julia Wisniew- Dr. Lucia Fil ı1, Dr. Alessandra Vultaggio 1, Dr. Elisa Cardilic- ski, MD 1, Paul Wright 1, William W. Kwok, PhD 2, Ronald chia1, Dr. Cinzia Manuelli 1, Dr. Andrea Casini 2, Dr. Francesca Turner, MD 1 and Judith A. Woodfolk, MBChB, PhD, FAAAAI 1, Nencini1, Dr. Laura Maggi 1, Dr. Sara Pratesi 1, Dr. Giulia Petroni 1, 1 University of Virginia Health System, Charlottesville, VA, (2)- Dr. Francesca Boscaro 3, Prof. Ernesto Giovanni Occhiato 2, Prof. Benaroya Research Institute at Virginia Mason, Sergio Romagnani 1, Prof. Enrico Maggi 1 and Prof. Paola Seattle, WA TUESDAY

151 AB398 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

LATE-BREAKING ABSTRACTS PRESENTED AT SCIENTIFIC SESSIONS AAAAI ANNUAL MEETING FEBRUARY 28-MARCH 4, 2014

The following abstracts were accepted for presentation after the deadline for the abstract supplement

Human TNFR2 Exhibits Bi-Directional Control over Regulatory only when prolines were hydroxylated. of the HYP-domain did T Cells L1 not prevent the variant to refold correctly and to display Ara h 2 Dr. Denise L. Faustman, MD, PhD 1, Limei Wang 2, Yoshiaki Okubo 2; conformational epitopes. The IgE-binding capacity of Ara h 2 was then 1Massachusetts General Hospital/Harvard Medical, Charlestown, MA, recapitulated with an equimolar mixture of the deletion variant and the 2Massachusetts General Hospital/Harvard Medical. synthetic HYP-peptide. Surprisingly, the HYP-peptide was also able to BACKGROUND: The homeostatic functions of CD4+ regulatory T-cells trigger the degranulation of RBL cells as efficiently as the unfolded Ara h 2, (Treg) protect against autoimmunity, cancer and infections, but mecha- which retained an allergenic activity with most of the tested sera. nisms governing Treg activity are ill-defined. We hypothesized that tumor CONCLUSIONS: Proline hydroxylation is critical for Ara h 2 allerge- necrosis factor receptor 2 (TNFR2) may control Treg functions, consid- nicity and peptides overlapping the HYP-domain, as short as 15 and 27 ering that TNFR2 is highly expressed on human Tregs. amino acid residues, retain an anaphylactic potential. METHODS: Effects of TNFR2 monoclonal antibodies (moAbs) on Treg proliferation, signaling, phenotype, and function were studied by multiple Immunocap Cellulose Displays Cross-Reactive Carbohydrate in vitro assays using isolated fresh human CD4+ and CD25hi coexpressing L3 Epitopes and Can Cause False-Positive Test Results in Patients T cells from >100 donors. Antibody performance was compared to with Anti-CCD IgE Antibodies standard Treg expansion methods and categorized as agonist, antagonist Wolfgang Hemmer, PhD 1, Stefan Wohrl, MD, MSc, FAAAAI 1, Felix or neutral in activity. Wantke, MD, FAAAAI 1, Friedrich Altmann, PhD 2; 1Floridsdorf Allergy RESULTS: Two antibodies exclusively acted as either a TNFR2 agonist or Center, Vienna, Austria, 2Department of Chemistry, University of Natural antagonist. In vitro the newly identified TNFR2 agonist induced prolifera- Resources and Life Sciences, Vienna, Austria. tion of enriched human T regs into phenotypically homogeneous RATIONALE: Cross-reactive carbohydrate determinants (CCDs) in plant hi + hi populations of effector Tregs (FOXP3 CD45RO CD25 HLA- and insect venom extracts are a common cause of false-positive results DR +CTLA4+, CD127-CXCR3-). Conversely, the TNFR2 antagonist sup- during in vitro allergy diagnosis. We noticed, when using the Phadia pressed human Treg proliferation. When Tregs were co-incubated with ImmunoCAP system, that some CCD-positive sera deliver multiple posi- their target CD8+ T-cells, the agonist-treated Tregs suppressed CD8+ tive results even when tested with CCD-free recombinant allergens. proliferation, whereas the antagonist had negligible effects. The two METHODS: ImmunoCAP IgE binding to selected recombinant allergens ligands also triggered different downstream intracellular Treg signaling, and to blank ImmunoCAPs (BIC) with no allergens coupled to the with the agonist upregulating TRAF2, FOXP3 and cIAP2. cellulose sponge was compared in CCD-positive sera before and after CONCLUSIONS: The findings show that certain TNFR2 ligands can act inhibition with a CCD inhibitor (ProGlycAn, Vienna, Austria). as antagonists or agonists by exerting opposing actions in human cells RESULTS: 30/45 (67%) CCD-positive sera (MUXF-CCD 1.01-59.6 kU/l) regarding Treg proliferation, signaling, and target cell activity. TNFR2 has showed IgE-binding to BIC greater than 0.35 kU/l (0.41-6.66 kU/l). the potential for bidirectional control over Treg homeostatic functions in Among those with anti-CCD IgE levels >7.0 kU/l, 86% (24/28) were humans, opening new clinical opportunities for Treg expansion or positive. IgE-binding to BIC correlated with IgE-binding to MUXF-CCD suppression. (r 50.66) and was completely abolished by serum pre-incubation with a CCD inhibitor (n 511). Binding scores with a second lot of BIC were lower Contribution of Sequential and Conformational IgE-Binding but correlated strongly with the first lot (r 50.99). IgE-binding of seven Epitopes to the Allergenicity of Major Peanut Allergen Ara h 2 L2 highly CCD-reactive sera (14.0-52.5 kU/l) to the recombinant allergens Stephane Hazebrouck, PhD1, Blanche Guillon, BSc 1, Marie-Franc¸oise rPhl p12, rFel d1, rAra h2, and rPru p3 was positive to all four components Drumare, BSc1, Evelyne Paty, MD 2, Jean-Michel Wal, PhD 1, Herve (up to 1.6 kU/l). Binding correlated strongly with antibody binding to Bernard, PhD1; 1INRA UR496, Gif-sur-Yvette, France, 2Universit e Paris MUXF-CCD and BIC (r 50.92) and could be completely blocked by the Descartes, Hopital^ Necker Enfants Malades, Paris, France. CCD inhibitor. Mass spectroscopic analysis confirmed the presence of RATIONALE: Protein unfolding reduces significantly the allergenic MMXF glycans in unprocessed and processed cellulose. activity of the most potent peanut allergen Ara h 2. This allergen also CONCLUSIONS: Cellulose used as an allergen carrier in the contains major sequential IgE-binding epitopes, especially in a flexible ImmunoCAP system contains varying traces of CCDs itself, which can region comprising the repetitive post-translationally modified peptide cause multiple false-positive results even to non-glycosylated recombi- DPYSPOH S, with a hydroxyproline (HYP). We then investigated the nant components in patients with elevated levels of anti-CCD IgE relative contributions of sequential and conformational epitopes to the antibodies. allergenic activity of Ara h 2. METHODS: Peptides overlapping the HYP-domain were synthesized with or without the prolines hydroxylated. A variant lacking the HYP-domain was generated by deletion mutagenesis. IgE reactivity of 19 peanut-allergic patients toward synthetic peptides and recombinant Ara h 2 variants was determined by IgE-binding inhibition assays and by degranulation tests of rat basophil leukemia (RBL) SX38 cells sensitized with patients’ IgE antibodies. RESULTS: The peptide encompassing the longest HYP-domain exhibited an inhibitory capacity similar to that of the full-length unfolded Ara h 2, but

152 J ALLERGY CLIN IMMUNOL Abstracts AB399 VOLUME 133, NUMBER 2

The RNA-Binding Protein Hur Is Required to Control Cytokine Sputum Cytokines and Adult Asthma Endotypes L4 Expression in CD4+ T Cells L6 Dr. Ioana O. Agache 1, Dr. Costel Agache 2, Mrs. Beate R uckert€ 3, Dr. Ulus Atasoy, MD, FAAAAI 1, Dr. Patsharaporn Techasintana 2, Prof. Liliana Rogozea1, Dr. Cristina Ciobanu 2, Prof. Cezmi A. Akdis, MD, Dr. Joseph Magee 2, Dr. Matt Gubin 3, Mr. Joe Rowles 2; 1Surgery, FAAAAI 4; 1Transylvania University Brasov, Romania, 2Theramed University of MO-Columbia, Columbia, MO, 2University of Missouri, Medical Center, Romania, 3Swiss Institute of Allergy and Asthma 3Washington University. Research, Switzerland, 4Swiss Institute of Allergy and Asthma Research, RATIONALE: During T cell activation, up to 50% of changes occur at the Davos, Switzerland. posttranscriptional level, which is mediated by RNA-binding proteins RATIONALE: Asthma clusters can be separated according to their (RBPs). HuR is a stabilizing RBP which regulates mRNA target expression endotype by combining visible properties and sputum cytokines. via AU-rich elements present in mRNA 3’UTRs. It is permissive for Th2 METHODS: The Local Ethics Committee approved the study. Induced and Th17 differentiation. sputum sampled outside an exacerbation was processed by dialysis METHODS: Previously, we showed HuR regulates GATA-3, IL-4, IL-13 (D-Tube Dialyzers Midi, Novagen) followed by ultrafiltration (Amicon and other Th2 restricted transcripts, as well as IL-17. We hypothesized that Ultra 3K, Millipore, 3000 NMWL). Sputum cytokines were measured with HuR is required for Th2 differentiation and Th2 associated disease such as the 27 Plex Human Cytokine Group I Bioplex (Biorad). Hierarchical asthma. To avoid defects in T cell development, we utilized a HuR KO cluster analysis with a wide array of variables was used. Difference mouse model in which HuR is ablated in mature CD4+ T cells, using distal between clusters was assesed by One-way Anova. Lck-Cre-ROSA-HuRfl/fl. RESULTS: 60 adult asthmatics, mean age 44 614 years old, 52% females RESULTS: Activated or Th2 polarized HuR KO CD+4 T cells showed were included. Three clusters were separated, significantly different for striking increases in IL-2 secretion and an inability to shut off IL-2 expression. all sputum cytokines (except RANTES and FGF-b), asthma severity Thesealso micehad profound reductions in Th2 and Th17 cytokine expression. (GINA), onset of asthma, ACT score, lung function (LF), AHR, We used the ova challenge model of airway inflammation to further exacerbation frequency, near-fatal asthma (NFA), corticosteroid-resis- investigate HuR KO under antigenic conditions. HuR KO mice had profound tance, blood eosinophils. Cluster 1 (n 527, 67% males) had the lowest reductions in BAL IL-4 and IL-13, and in pulmonary cellular infiltration frequency of asthma exacerbations, the best LF, predominant macrophages with suppression of neutrophils, lymphocytes and eosinophils. The levels of and lymphocytes in induced sputum and the highest sputum IL-4, IL-1RA, cellular infiltration in HuR KO mice resembled un-immunized controls. VEGF and IL-7. Cluster 2 (n 514, 64.3% females) had the longest asthma CONCLUSIONS: HuR appears to be required for Th2 and Th17 but not duration, the highest AHR and frequency of asthma exacerbations, Th1 differentiation and cytokine production. Furthermore, HuR functions corticosteroid-resistance and NFA, the worst LF and ACT score, the as an off switch for IL-2 expression during T cell activation. These results highest sputum and blood eosinophilia and the highest sputum cytokines. may have implications for understanding mechanisms of tolerance under Cluster 3 (n 519, 63.2% females), had the shortest asthma duration, the antigen challenge as well as in allergen driven airway lung inflammation. highest FeNO and total serum IgE, the highest incidence of LF decline and atopy, sputum neutrophilia and the lowest values for all sputum IKBKB Whole-Exome Sequencing Reveals As a Cause of cytokines. L5 Combined Immunodeficiency CONCLUSION: Deep phenotyping incorporating phenotypic traits, 1,2 1 Dr. Talal Mousallem, MD , Dr. Jialong Yang, PhD , Dr. Thomas J. longitudinal data and biomarkers of inflammation stratifies asthma into 2 1,3 Urban, PharmD, PhD , Mrs. Hongxia Wang, MS , Mrs. Roberta E. subclasses according to their biological basis. Parrott, BS 1, Dr. Joseph L. Roberts, MD, PhD 1, Dr. Rebecca H. Buckley, MD, FAAAAI 1, Dr. Xiaoping Zhong, MD, PhD 1, Dr. David B. Omalizumab Therapy Is Associated with Reduced Circulating Goldstein, PhD2; 1Department of Pediatrics, Duke University Medical L7 Basophil Populations in Asthmatic Children Center, Durham, NC, 2Center for Human Genome Variation, Duke Dr. David A. Hill, MD, PhD 1, Dr. Mark Siracusa, PhD 2, Kathryn University Medical Center, Durham, NC, 3Laboratory Medicine Center, Ruymann1, Dr. Elia Tait Wojno, PhD 2, Dr. David Artis, PhD 2, Nanfang Hospital, Southern Medical University, Guangzhou, China. Dr. Jonathan M. Spergel, MD, PhD, FAAAAI 1; 1The Children’s Hospital RATIONALE: There is considerable interest in the use of next generation of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, sequencing to identify molecular defects in patients with primary Philadelphia, PA. immunodeficiency. RATIONALE: Basophils have been implicated in promoting the early METHODS: To identify the cause of Combined Immunodeficiency in 2 development of TH2 cell responses in some murine models of TH2 patients from 2 different consanguineous Qatari families who had a similar cytokine-associated inflammation. However, the specific role of basophils clinical and immunologic phenotype, we used whole-exome sequencing. in allergic asthma remains an active area of research. Recent studies in The patients presented at an early age with fungal, viral and bacterial animal models and human subjects suggest that IgE may regulate the infections. The patients had hypogammaglobulinemia, normal numbers of homeostasis of human basophil populations. Here, we examine basophil B and T cells (most of which were CD45RA positive) and low numbers of populations in children with severe asthma before and during therapy with NK cells. T cell proliferative responses to mitogens were normal, but were the IgE directed monoclonal antibody omalizumab. absent to antigens and anti-CD3. We looked for homozygous variants that METHODS: Subjects were selected based on age between 5 and 18 years, were present in the patients but absent in controls and public databases. body weight and IgE level compatible with the omalizumab dosing table, Additional studies included IKKb, IKB a, and phospho-IKB a immuno- and severe asthma. Asthma symptoms assessments were administered blotting, retroviral mediated reconstitution of IKK b, and cell growth in an during therapy. Peripheral blood samples were obtained before and during immortalized patient B cell line. therapy and basophil frequencies and numbers were monitored using flow RESULTS: We found the same homozygous nonsense mutation in IKBKB cytometric techniques. (R286X) in both patients. IKK b acts as part of the IKK complex in NF- kB RESULTS: Omalizumab therapy wasassociatedwith a significantreduction activation and phosphorylates the NF- kB inhibitor, IKB a. The mutation in circulating basophil frequencies and numbers (p <0.05, Wilcoxon Signed co-segregated with disease in both families. Western blotting showed Rank Test), a finding that correlated with improved clinical outcomes. absence of detectable IKK b, and retroviral mediated reconstitution with CONCLUSIONS: The observation that circulating basophils are reduced wild type IKKb corrected cell growth and restored IKBa phosphorylation following omalizumab therapy supports a mechanistic link between and IKBa degradation in an EBV transformed patient B cell line. IgE levels and circulating basophil populations and may provide new CONCLUSION: These data indicatethat mutated IKBKB is the likely cause insights into one mechanism by which this drug improves asthma of immunodeficiency in these two patients. To our knowledge, this is the symptoms. first report of combined immunodeficiency caused by a mutation in IKBKB .

153 AB400 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Elucidating the Basis of Airway Protection By Gastrointestinal Diseases, Seoul, South Korea, South Korea, 15 Department of Pediatrics, Inje L8 Lactobacillus Johnsonii University Sanggye Paik Hospital, Seoul, South Korea, 16 Department of Pedi- Dr. Kaitlyn S. Lucey, PhD 1, Dr. Kei Fujimura, PhD 1, Dr. Marcus atrics, Asan Medical Center, Childhood Asthma Atopy Center, South Korea. Rauch, PhD1, Ali Faruqi 1, Douglas Fadrosh 1, Dr. Tine Demoor, PhD 2, RATIONALE: Although cesarean delivery and prenatal exposure to Dr. Christine Cole Cole Johnson, PhD, MPH, FAAAAI 3, Dr. Homer A. antibiotics are likely to affect the gut microbiome in infancy, their effect on Boushey, Jr, MD, FAAAAI 1, Dr. Edward M. Zoratti, MD, FAAAAI 3, the development of atopic dermatitis (AD) in infancy is unclear. The Dr. Dennis Ownby, MD, FAAAAI 4, Dr. Nicholas W. Lukacs, PhD 2, influence of individual genotypes on these relationships is also unclear. To Dr. Susan V. Lynch, PhD 1; 1University of California San Francisco, San evaluate with a prospective birth cohort study whether cesarean section, Francisco, CA, 2University of Michigan, Ann Arbor, MI, 3Henry Ford prenatal exposure to antibiotics, and susceptible genotypes act synergis- Health System, Detroit, MI, 4Department of Pediatrics Georgia Regents tically to promote the development of AD in infancy. University, Augusta, GA. METHODS: The study population comprised 412 infants from the Cohort RATIONALE: We recently demonstrated that the gram-positive, facul- for Childhood of Asthma and Allergic Diseases (COCOA). Their cord tative anaerobe, L. johnsonii , is significantly enriched in the cecal micro- blood DNA was subjected to IL13 (rs20541) and CD14 (rs2569190) biome of mice whose airways are protected against allergen and viral genotype analysis. Fecal samples were obtained from 11 of the 412 infants challenge, and that oral supplementation with this species alone can afford in this study at the age of 6 months and 16s rRNA bacterial gene airway protection. Current studies are aimed at deciphering the basis for sequencing was performed. gastrointestinal L. johnsonii protection of the airways. RESULTS: The combination of cesarean delivery and prenatal exposure METHODS: L. johnsonii was isolated from airway protected mice, and its to antibiotics associated significantly and positively with AD (aOR, 5.70; genome was sequenced using the Illumina MiSeq platform. The gut micro- 95% CI, 1.19–27.3). The association between cesarean delivery and AD biome composition of mice supplemented with L. johnsonii was compared to was significantly modified by parental history of allergic diseases or risk- unsupplemented animals, and used in conjunction with a metagenome predic- associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. Infants who tive tool, PICRUSt, to compare the functional capacity of these communities. were exposed prenatally to antibiotics and were born by cesarean delivery RESULTS: L. johnsonii preferentially localizes in the terminal ileum and had lower total microbiota diversity in stool samples at 6 months of age cecum. While its 16S rRNA is 99% homologous to L. johnsonii NCC 533, than the control group. As the number of these risk factors increased, the only 85% of the assembled contigs of its 2Mb genome are identical, sug- AD risk rose (trend p <0.05). gesting that 15% of its genome is distinct from this species. Genes relevant CONCLUSION: Cesarean delivery and prenatal antibiotic exposure may to colonization, survival, and inter-species competition in the gut are pre- affect thegut microbiota, whichmay inturninfluencethe risk of AD in infants. sent. Oral supplementation of mice with L. johnsonii is associated with sig- These relationships may be shaped by the genetic susceptibility alleles. nificant enrichment of specific members of the Bacteroides, Proteobacteria, Firmicutes, Spirochaetes, Cyanobacteria, and Caldiserica The Role of Chitin and TNF-Alpha in Airway (Welch’s t-test p-value < 0.05, q-value < 0.16) and collectively this com- L10 Induced By House Dust Mite in Murine Model munity imparts a myriad of immunomodulatory functions. Prof. Sang Min Lee, MD 1, Mr. Joon Pyo Choi, PhD 2, Young Min Kim 2, CONCLUSION: L. johnsonii is a crucial species of the gut microbial Seung Jin Choi2, Hyun Taek Park 2, Prof. Sang Pyo Lee, MD, PhD 3, community that reshapes community composition and function in a Prof. Sang Heon Cho, MD, PhD4,5, Prof. Yoon-Keun Kim, MD, PhD 2; manner that affords airway protection in mice. 1Department of InternalMedicine,Gachon University Gil Medical Center, In- 2 IL-13/CD14 Polymorphisms and Prenatal Risk Factors That Shape cheon, South Korea, Division of Molecularand Life Sciences, Department of Life Science, Pohang University of Science and Technology (POSTECH), L9 Gut Microbiota Influence the Development of Atopic Dermatitis 3 in Infancy in a Synergistic Manner: A Birth Cohort Study Pohang, South Korea, Department of Internal Medicine, Gachon University Gil Medical center, Incheon, South Korea, 4Department of Internal Medicine, (COCOA) 5 Prof. So Yeon Lee, MD, PhD 1, Prof. Hae-Ran Lee 2, Kang Mo Ahn 3, Seoul NationalUniversity College of Medicine,Seoul, South Korea, Institute Prof. Kyung Won Kim, MD, PhD 4, Prof. Youn Ho Shin, MD, PhD 5, of Allergy and Clinical Immunology, Seoul National University Medical Gyeong-shin Lee 6, Seo Ah Hong 7, Dr. Young-Ho Ho Jung, MD 8, Research Center, Seoul, South Korea. Dr. Eun Lee, MD 9, Song-Yi Yang 10 , Dr. Ju-Hee Seo, MD 11 , Ji-Won BACKGROUND: Chitin is a potent adjuvant in immune responses of Th2, Kwon12 , Dr. Byoung-Ju Kim, MD, PhD 13,14, Dr. Byoung-Ju Kim, MD, Th1 and Th17. In our previous study, tumor necrosis factor – alpha (TNF-a) is PhD13,14, Dr. Hyo-Bin Kim, MD, PhD 14,15, Prof. Soo-Jong Hong, MD, a key mediator in the development of Th2 cell response to inhaled allergens. PhD16 ; 1Department of Pediatrics, Hallym University College of Medicine, OBJECTIVE: We investigated the role of chitin in the induction of Th1, Seoul, South Korea, 2Hallym University, South Korea, 3Department of Pe- Th2, and Th17 response, sensitizing and challenging mice intranasally with diatrics, Samsung Medical Center, Sungkyunkwan University School of OVA and chitin in this study. We also evaluated the role of TNF- a and the Medicine, Seoul, Korea, South Korea, 4Department of Pediatrics, Severance size of chitin in the development of Th2 immune response induced by chitin, Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea, using TNF- a-deficient mice and chitinase-treated chitin, respectively. Seoul, South Korea, 5Department of Pediatrics, CHA Medical Center, CHA METHODS: A mouse model was generated via simultaneous intranasal University College of Medicine, Seoul, South Korea, 6Childhood Asthma administration of 75 mg of ovalbumin (OVA)and 100 mg of house dust mite Atopy Center, Asan Medical Center, University of Ulsan College of Medi- (HDM)-derived chitin in the presence or absence of chitinase. The effect of cine, South Korea, 7Research Center for Standardization of Allergic Dis- TNF-a on adaptive immune response was also evaluated using TNF- a- eases, Asan Institute for Life Sciences, University of ulsan College of deficient mice. Medicine, South Korea, 8Childhood Asthma Atopy Center, Department of RESULTS: HDM-derived chitin induced airway inflammation and Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, increased the expression of all cytokines of Th1, Th2, and Th17 as well Seoul, South Korea, 9Childhood Asthma Atopy Center, Asan Medical Cen- as the serum level of OVA-specific IgE, IgG1, and IgG2a. In the absence of ter, University of Ulsan College of Medicine, South Korea, 10 Childhood TNF-a or in the presence of chitinase, the expression of Th2 cytokines and Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, Uni- the serum level of OVA-specific IgE were alleviated, while the expression versity of Ulsan College of Medicine, South Korea, 11 Department of pediat- of Th1 and Th17 cytokines and the serum level of OVA-specific IgG1 and rics, Korea Cancer Center Hospital, South Korea, 12 Department of Pediatrics, IgG2a were preserved or more enhanced. Seoul National University Bundang Hospital, South Korea, 13 Department of CONCLUSION: HDM-derived chitin is size-dependent multifaceted Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, immune adjuvant inducing Th1, Th2, and Th17 immune response, and Busan, South Korea, 14 Research Center for Standardization of Allergic TNF-a produced by airway exposure to HDM-derived chitin is a key mediator in the development of Th2 cell response to inhaled allergens.

154 J ALLERGY CLIN IMMUNOL Abstracts AB401 VOLUME 133, NUMBER 2

Platelets Constitutively Express Interleukin-33 Protein Exome Sequencing Project. In functional studies conducted thus far, we L11 Dr. Tomohiro Takeda, MT, PhD 1,2 , Dr. Hirotoshi Unno, MD 1, observed that an 8-year-old boy carrying the Val14Met variant had a blunt- Dr. Hideaki Morita, MD, PhD 1, Dr. Hirohisa Saito, MD, PhD 1, Dr. Kenji ed response to IFN- g induced CD80 expression. Matsumoto, MD, PhD1, Dr. Akio Matsuda, PhD 1; 1Department of Allergy CONCLUSIONS: Our novel findings provide evidence that functional and Immunology, National Research Institute for Child Health and polymorphisms in IFNGR1 contribute to ADEH+ susceptibility. Development, Tokyo, Japan, 2Department of Health Sciences, Kansai Additional functional studies are underway. University of Health Sciences, Osaka, Japan. RATIONALE: Recent studies revealed that platelets are activated during Grass Pollen Allergoids Coupled to Mannan Are Novel asthma exacerbation and that depletion of platelets in a mouse model of L13 Vaccines with Enhanced Capacity to be Captured By asthma improves airway inflammation. However, the precise mechanisms Dendritic Cells Promoting Th1 Immune Responses and High Levels of IL-10 of how platelets—despite being devoid of a nucleus—regulate allergic 1 1 inflammation are not fully understood. IL-33, an IL-1 family cytokine, has Dr. Oscar Palomares, PhD , Dr. Sofia Sirvent, PhD , Dr. Irene 2 3  4 attracted attention as a critical cytokine in the development of allergic Soria, PhD , Dr. Barbara Cases, PhD , Dr. Carmen D ıez, PhD , 4  ~ 4 diseases because of its potent ability to induce type 2 immunity and its Dr. Pedro Reche, PhD , Dr. Juan L opez-Rela no, PhD , Dr. Eduardo Martınez-Naves, PhD4, Dr. Enrique Fernandez-Caldas, PhD 3, Dr. Jose strong genetic association with asthma. Objective: To determine whether 3 1 platelets express IL-33 protein. Luis Subiza, MD, PhD ; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Madrid, Spain, 2Hospital Cl ınico San Car- METHODS: IL-33 protein in human platelets and a megakaryocyte cell 3 4 line, MEG-01, and in bone marrow-derived mouse megakaryocytes was los, Madrid, Spain, Inmunotek, Madrid, Spain, Department of Immu- detected by Western blot analysis and fluorescent immunostaining. Papain nology, School of Medicine, Complutense University, Madrid, Spain. inhalation (100 mg/day 3 3 days)-induced IL-33-dependent airway RATIONALE: The immunogenicity and efficacy of allergen vaccines inflammation (Oboki K. et al. PNAS 2010) was compared between depend on the capacity of dendritic cells (DCs) to capture them and to platelet-intact and platelet-depleted (by injection of anti-CD41 mAb)groups. induce proper immune responses. Herein, we compared the ability of RESULTS: Human platelets and anucleated fragments of mouse bone- native grass pollen extracts (N), glutaraldehyde-polymerized allergoids (P) marrow-derived megakaryocytes expressed full-length IL-33 protein, and glutaraldehyde-polymerized allergoids coupled to mannan (PM) to be which is biologically active. Cytosol, but not nuclear, fractions of MEG- internalized by DCs and to regulate immune responses. 01 and mouse megakaryocytes also expressed full-length IL-33 protein. METHODS: N, P and PM Phleum pratense pollen extracts were pro- Depletion of platelets resulted in a significant decrease in eosinophilic, but duced. Human monocytes from buffy coats were differentiated to DCs not neutrophilic, inflammation in papain-treated mouse airways. with IL-4/GM-CSF. Allergen uptake was assessed by flow cytometry and CONCLUSIONS: Our novel findings suggest that platelets constitutively confocal microscopy. Co-culture experiments, real-time quantitative express active IL-33 protein and that activation of platelets plays a pivotal PCR, ELISA and ELISPOT were performed. Antibody levels in serum role in IL-33-dependent type II airway inflammation. Further understand- from BALB/c mice immunized with extracts, proliferation of splenocytes ing of the precise molecular mechanisms may lead to platelets’ becoming and cytokine production were determined. an attractive new target in asthma treatment. RESULTS: PM was captured by human DCs more efficiently than N or P through mechanisms partially depending on receptor-mediated internali- Targeted Resequencing Identified Damaging Rare Variants in zation. DCs stimulated with N, P and PM expressed high levels of HLA- L12 IFNGR1 Associated with Atopic Dermatitis Complicated By DR, CD86 and CD83. PM-activated DCs produced higher levels of IL-6 Eczema Herpeticum and IL-10 than N- or P-activated DCs. Allogeneic and allergen-specific co- Dr. Li Gao, MD, PhD 1, Dr. Ryan Heiser, PhD 2, Nicholas M. Rafaels 1, cultures showed that PM-activated DCs generated T cells producing higher Lili Huang, MPH1, Joseph Potee 1, Dr. Rasika A. Mathias, ScD 1, Lisa A. levels of IFN-gamma and IL-10 and lower levels of IL-5 or IL-4 than N- or Beck, MD, FAAAAI 3, Dr. Kathleen C. Barnes, PhD, FAAAAI 1, Donald P-activated DCs. Splenocytes from mice immunized with PM showed a Y. M. Leung, MD, PhD, FAAAAI 2; 1Division of Allergy and Clinical Th1 cytokine-signature and high levels of IL-10 with higher proliferation Immunology, Department of Medicine, Johns Hopkins University, than those from mice immunized with N or P. Baltimore, MD, 2National Jewish Health, Denver, CO, 3Department of CONCLUSIONS: Grass pollen hypoallergenic allergoids conjugated to Dermatology, University of Rochester Medical Center, Rochester, NY. mannan may represent safer and more effective novel vaccines due to their RATIONALE: Genetic variations in IFNGR1 gene have been reported enhanced immunogenicity and capacity to promote Th1 mediated T cell that abrogate IFN-g signaling leading to enhanced susceptibility to myco- responses to allergens. bacterial infection. However, the causality of IFNGR1 variants in atopic dermatitis with eczema herpeticum (ADEH+) has not been established. Utilizing targeted resequencing, we assess the influence of rare functional variations in IFNGR1 to ADEH+ susceptibility. METHODS: We performed targeted resequencing in 122 European American (EA) ADEH+ cases and 107 ADEH- controls followed by validation genotyping for 3 rare missense variants in the entire cohort including a total of 411 EA patients (133 ADEH+, 157 ADEH- and 121 non-atopic controls (NA)). Association tests between rare variants and risk of ADEH+ was performed using SKAT-O. The IFN- g induced CD80 expression on peripheral blood mononuclear cells (PBMC) was examined in a selected group of patients. RESULTS: We identified 18 common and 118 rare variants in IFNGR1. Among the rare variants, 6 were missense with 3 as possibly damaging (Val14Met, Val61Ile and Tyr397Cys) including one novel variant (Tyr397Cys). The 3 damaging rare variants conferred greater risk for ADEH+ (P <0.031) when we compared 133 ADEH+ patients including 5 heterozygous carriers to 278 non-ADEH+ subjects (157 ADEH-, 121 NA). Enhanced signal was observed (P <7.48E-14) when we compared findings to an unphenotyped control population (4300 EAs) from the

155 AB402 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Upregulated Matrix Metalloproteinase 2/9 Activity in Murine Efficacy and Safety of Lebrikizumab in Severe Uncontrolled L14 Asthma Detected with Activatable Cell-Penetrating Peptides L16 Asthma: Results from the Lute and Verse Phase II Csilla N. Felsen , Elamprakash N. Savariar, Michael Whitney, Roger Y. Randomized, Double-Blind, Placebo-Controlled Trials Tsien; University of California, San Diego. Nicola A. Hanania, MD 1, Michael J. Noonan, MD 2, Jonathan RATIONALE: Asthma, an airway inflammatory disease characterized by Corren, MD 3, Phillip Korenblat, MD, FAAAAI 4, Yanan Zheng, PhD 5, intermittent airway obstruction, affects more than 300 million people Wendy Putnam, PhD 5, Elaine Murray, MD 5, Connie Abelardo, MD 5, worldwide. Matrix metalloproteinase 2 and 9 (MMP2/9) mRNA and Heleen Scheerens, PhD5, Romeo Maciuca, PhD 5, Sarah Gray, PhD 5, protein levels correlate with asthma pathogenesis; however, the role of Ramona Doyle, MD 5, Dana McClintock, MD 5, John G. MMP2/9 in asthma is not well understood, particularly because previous Matthews, MBBS, MRSCP, PhD 5, Karl Yen, MD, MMSc, FAAP 5; studies have not evaluated protease activity. We report the application of 1Baylor College of Medicine, Houston, TX, 2Allergy Associates activatable cell-penetrating peptides (ACPPs), injectable probes that Research, Portland, OR, 3Allergy Medical Clinic, Los Angeles, CA, highlight in vivo protease activity, to assess protease activity in murine 4Clinical Research Center LLC, St. Louis, MO, 5Genentech, Inc., South asthma. San Francisco, CA. METHODS: Asthma mice were sensitized (ovalbumin [OVA] + alum in RATIONALE: A subset of severe asthma patients are inadequately saline [PBS]) and then challenged (OVA in PBS). Age-matched control controlled despite treatment with inhaled corticosteroids (ICS) and a mice were sensitized but not challenged. The day after the final OVA second controller. Lebrikizumab is a humanized antibody to IL-13, a key challenge, ACPPs (cleavable and uncleavable, n 5 3-6 mice each) were effector cytokine in asthma pathogenesis. In a previous Phase 2 trial, administered intravenously 6 hr before mice were sacrificed. Lungs were lebrikizumab treatment increased forced expiratory volume in 1 sec

imaged for Cy5 fluorescence (Maestro, CRi). Lung sections (10 mm, 8 (FEV1), particularly in patients with higher blood periostin levels. images/mouse) were imaged for Cy5 fluorescence on a confocal micro- METHODS: LUTE and VERSE were replicate, multicenter, double- scope (5Live, Zeiss) and stained with hematoxylin and eosin. blind studies that randomized (1:1:1:1) patients with uncontrolled RESULTS: MMP2/9 activity was > 2-fold higher in lungs from asthma asthma despite treatment with ICS and a second controller to receive 2 mice than controls (p 5 1.8310 4). The same pattern was observed for ra- lebrikizumab 37.5mg, 125mg, 250mg, or placebo subcutaneously every tiometric ACPPs. MMP2/9 activity localized around inflamed airways with 4 weeks. The primary endpoint was the rate of exacerbations.

1.6-fold higher ACPP uptake surrounding airways compared to the normal Secondary endpoints included change in FEV 1. The trials, initially lung parenchyma (p 5 0.03). MMP2/9 activity detected by ACPPs Phase 3, were converted to Phase 2b upon identification of a process- co-localized with gelatinase activity measured with in situ DQ gelatin. related impurity requiring changes to the lebrikizumab manufacturing CONCLUSIONS: MMP-activated ACPPs allow for real-time detection process. of protease activity in a murine asthma model, improving our understand- RESULTS: 463 patients were pooled for analysis. The median number ing of protease activation in asthma progression and elucidating novel of doses received was 6 (range 1–12). Compared with placebo (n 5116), therapy targets. the exacerbation rate (95% CI) was reduced by 62% (23%–83%; n5117), 35% ( 217%–65%; n 5112), and 11% ( 254%–49%; n 5118) Asthma and Airway Hyperresponsiveness in Children with in all patients and by 81% (35%–97%), 77% (26%–95%), and L15 Eosinophilic Esophagitis: EGF and FGF-2 As a Link 22% (262%–63%) in periostin-high ( >_50ng/mL) patients in the 1 2 Dr. Nadia L. Krupp, MD , Prof. Sarita Sehra, PhD , Dr. Sandeep K. lebrikizumab 37.5mg, 125mg, and 250mg groups, respectively. At 1 1 3 Gupta, MD , Prof. Mark H. Kaplan, PhD , Dr. Robert S. Tepper, MD ; Week 12, increases in FEV were greater for lebrikizumab versus pla- 1 2 1 Indiana University School of Medicine, Indianapolis, IN, Indiana cebo, particularly in periostin-high patients. No important safety signals 3 University School of Medicine, Riley Hospital for Children, Indianapo- were observed. lis, IN. CONCLUSIONS: Lebrikizumab treatment reduced the exacerbation rate RATIONALE: Asthma is prevalent in children with eosinophilic esoph- and increased FEV1 in patients with uncontrolled asthma on ICS and a sec- agitis (EoE), previously estimated at 24-42% versus 9% for the general ond controller, particularly those who were periostin-high, confirming the population. However, studies of pulmonary function and airway hyper- findings from the previous Phase 2 trial. responsiveness (AHR) in children with EoE are lacking. METHODS: A cross-sectional study was conducted of children aged 6-18 years with EoE and healthy controls. Methacholine challenge (AHR defined as provocative concentration of methacholine <8mg/ml), and exhaled nitric oxide were performed. Peripheral blood was analyzed for total IgE, eosinophil count, eotaxin, and serum cytokines. RESULTS: Baseline spirometry was normal and not significantly different for EoE subjects (n 533) and healthy controls (n 537). AHR was present in 33% of children with EoE and 10.8% of healthy controls (p 50.04). 20% of EoE subjects with asthma (n 515) had AHR, versus 44% of EoE subjects without asthma (n 518). Overall, 69.7% of EoE subjects had either asthma or AHR. AHR correlated strongly with serum IgE (p <0.0001) and exhaled nitric oxide (p 50.0002). Epidermal growth factor (EGF) and fibroblastic growth factor 2 (FGF-2) were elevated in subjects with EoE and asthma , compared to healthy controls and those with EoE but no asthma (p <0.05). Subjects with EoE and asthma who were on asthma controller medications had similar levels of EGF and FGF-2 as healthy

controls. Th 2 cytokines and eotaxin did not differ significantly among any groups. CONCLUSIONS: Asthma and AHR may be more prevalent than previously estimated in children with EoE. Serum elevations of EGF and FGF-2 were seen in EoE subjects with asthma, but not in subjects on asthma controller medications.

156 J ALLERGY CLIN IMMUNOL Abstracts AB403 VOLUME 133, NUMBER 2

Dose-Finding Efficacy and Safety Trial of House Dust Mite subjects [23/34(67.6%)] consumed unbaked and baked egg vs. placebo L17 Sublingual Immunotherapy Tablet, MK-8237, Using an subjects [2/11(18.2%)] (p 50.006). 20/20 (100%) OIT-SU subjects were Environmental Exposure Chamber consuming all forms of egg in their diet. 7/8 (87.5%) OIT-D subjects were Dr. Hendrik Nolte, MD, PhD 1, Dr. Jennifer Maloney, MD 1, Dr. Harold S. consuming some egg; 3 unbaked and 4 only baked egg. 1/6 (16.7%) OIT- Nelson, MD, FAAAAI 2, Dr. David I. Bernstein, MD, FAAAAI 3, not-desensitized subjects were consuming only baked egg. 4/11 (36.4%) Dr. Ziliang Li, PhD 1, Rene Zieglmayer 4, Dr. Petra U. Zieglmayer, MD 4, placebos were consuming some egg; 2 unbaked and 2 only baked egg. Dr. Friedrich Horak, MD 4; 1Merck, Whitehouse Station, NJ, 2National CONCLUSIONS: Findings suggest sustainability of long-term egg Jewish Health, Denver, CO, 3Bernstein Allergy Group, Cincinnati, OH, consumption among subjects demonstrating SU after completion of egg 4Vienna Challenge Chamber, Vienna, Austria. OIT. Future work is needed to identify individuals who will benefit from RATIONALE: Sublingual immunotherapy with house dust mite (HDM) egg OIT. might be beneficial in patients with allergic rhinitis with/without conjunctivitis (AR/C), although reported effect size is small to moderate A Randomized, Double-Blind, Placebo-Controlled Trial of and varies greatly among studies. MK-8237 (Merck/ALK-Abell o) is a L19 Omalizumab Combined with Oral Immunotherapy (OIT) in sublingual HDM immunotherapy tablet currently under investigation. the Treatment of Cow's Milk Allergy (CMA): Safety of Dosing Dr. Jennifer S. Kim, MD, FAAAAI 1, Robert A. Wood, MD, FAAAAI 2, METHODS: In this randomized, double-blind, single-site trial adults with 3 1 5 Robert Lindblad, MD , Ms. Sally A. Noone, RN, MSN, CCRC , HDM-induced AR/C with/without asthma (n 124) received daily MK- 2 3 8237 12 DU, 6 DU, or placebo for 24 weeks, and underwent exposure Ms. Melissa N. Paterakis, RN, BSN , Alice Henning, MS , Dr. Kari C. Nadeau, MD, PhD, FAAAAI 4, Kyrsten Spann 4, Hugh A. Sampson, MD, challenges (Vienna Challenge Chamber) at weeks 8, 16, and 24. The 1 1 primary objective was to evaluate the dose-related efficacy of MK-8237 FAAAAI ; Icahn School of Medicine at Mount Sinai, New York, NY, 2Johns Hopkins University Medical Center, Baltimore, MD, 3The versus placebo on total nasal symptom score (TNSS) during chamber 4 challenge at week 24. TNSS was the sum of 4 nasal symptom scores EMMES Corporation, Rockville, MD, Stanford University, Stanford, (maximum512). CA. RESULTS: MK-8237 12 DU and 6 DU provided a 48.4% and 26.2% RATIONALE: Determine whether the addition of omalizumab reduces improvement, respectively, in TNSS at week 24 versus placebo (mean dosing-related side-effects in subjects with CMA undergoing milk OIT. difference: 23.62, P< .001 and 21.98, P5.003). TNSS improvements METHODS: Fifty-seven milk-allergic subjects (7-32 y/o) confirmed by were also observed at weeks 8 (mean difference: 21.37, 20.3%; DBPCFC with a milk-specific IgE >0.35 kUA/L and/or positive PST were P5.007) and 16 (mean difference: 22.08, 30.1%; P< .001) for the 12 randomized 1:1 to receive blinded omalizumab or placebo for 16 months. DU dose and week 16 (mean difference: 21.23, 17.8%; P5.032) for the Open-label milk OIT dosing was initiated after Month 4 of omalizumab/ 6 DU dose. Total symptom scores (nasal+ocular symptoms) were signifi- placebo with an escalation to maintenance over 22-40 weeks; goal - 3.84 g cantly improved by both doses versus placebo at week 24. Both doses of milk protein/day. MK-8237 were well tolerated, with no systemic allergic reactions or reac- RESULTS: At enrollment, there were no statistically significant differ- tions requiring epinephrine. ences between the omalizumab/placebo treatment arms for age, milk CONCLUSIONS: MK-8237 appears promising, with potential for high specific-IgE (39.4 vs. 42.0 kUA/L), milk PST wheal (10.0 vs. 8.0 mm) or and clinically meaningful (>20% reduction in symptoms) effect to be OFC dose at first symptom (20 vs. 20 mg). Three subjects withdrew prior to 5 further evaluated in field trials. A dose-dependent effect was observed, OIT dosing. Significant differences between the omalizumab (n 26) and 5 with the 12 DU dose exhibiting the best benefit/risk ratio. placebo (n 28) groups were seen for dose-related symptoms per subject during dose escalation and maintenance therapy through 16 months Long-Lasting Egg Consumption in Egg Allergic Children (median: 5.0 vs. 47.5; p50.0001), dosing reactions requiring treatment L18 Treated with Oral Immunotherapy (OIT): Follow-up from the (median: 1.0 vs. 12.0; p50.0003), and need for epinephrine (1 time in 1 Consortium of Food Allergy Research (CoFAR) Study omalizumab subject vs. 17 times in 9 placebo subjects). Significantly fewer Stacie M. Jones, MD 1, A. Wesley Burks, MD, FAAAAI 2, Robert A. doses were required to achieve maintenance dosing in the omalizumab Wood, MD, FAAAAI 3, David Mark Fleischer, MD, FAAAAI 4, Scott H. group (median: 198.0 vs. 224.5; p50.01) resulting in a shorter escalation Sicherer, MD, FAAAAI 5, Alice Henning, MS 6, Robert Lindblad, MD 7, phase with omalizumab (25.9 vs. 30.8 weeks; p 50.01). Peter Dawson, PhD 6, Brian P. Vickery, MD, FAAAAI 2, Corinne CONCLUSIONS: This is the first randomized, double-blinded, placebo- Keet, MD, MS 3, Andrew H. Liu, MD 4, Dr. Amy M. Scurlock, MD 1, controlled OIT trial demonstrating that omalizumab significantly reduces Hugh A. Sampson, MD, FAAAAI 5; 1University of Arkansas for Medical the dosing symptoms and treatment requirements, including epinephrine, Sciences and Arkansas Children’s Hospital, Little Rock, AR, 2University of OIT-related side-effects and reduces the time to achieve maintenance of North Carolina, Chapel Hill, NC, 3Johns Hopkins University Medical dosing. Future DBPCFCs will determine whether omalizumab improves Center, Baltimore, MD, 4National Jewish Health, Denver, CO, 5Mount the induction rate of desensitization and tolerance. Sinai School of Medicine, New York, NY, 6The EMMES Corporation, Rockville, MD, 7The EMMES Corporation, Ro, MD. RATIONALE: Egg OIT results in sustained unresponsiveness (SU) in a subset of egg-allergic children; however, long-term treatment effects off- therapy are not established. METHODS: Egg-allergic children (5-18 y/o) received egg OIT (n 540), maximum 4 years, or placebo (n 515), maximum 1 year. Through year 4, subjects were assessed as SU (passed OFC after 4-6 weeks off OIT) or desensitized (D) (passed OFC on therapy only). SU subjects were instructed to add unbaked egg ad libitum; other subjects added egg independent of physician instruction. Long-term, follow-up questionnaires (LFQ) were administered at a median of 61.6 months from enrollment to assess unbaked (lightly cooked) vs. baked (heat-denatured) egg consump- tion in current diet and symptoms. RESULTS: Of 40 egg OIT-treated subjects, 22/40(55%) were SU by year 4 (versus 27.5% at year 2). Of 8,925 egg OIT doses in years 2-4, 95% were symptom-free. 45/55 (81.8%) subjects completed the LFQ. More egg OIT

157 AB404 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Dupilumab Monotherapy in Adults with Moderate-to-Severe L20 Atopic Dermatitis: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study Prof. Thomas R. M. Bieber, MD, PhD, FAAAAI 1, Dr. Diamant Thaci, MD 2, Dr. Neil Graham, MD 3, Dr. Gianluca Pirozzi, MD, PhD 4, Dr. Ariel Teper, MD 4, Dr. Haobo Ren, PhD 5, Dr. Allen Radin, MD 3; 1Friedrich-Wilhelms University of Bonn, Bonn, Germany, 2Universit€at zu L ubeck,€ Lubeck, Germany, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4Sanofi, Bridgewater, NJ, 5Regeneron Pharmaceuticals, Inc., Basking Ridge, NJ. RATIONALE: Dupilumab, a human monoclonal antibody targeting the IL-4Ra subunit, blocks IL-4/IL-13 signaling. METHODS: This European trial randomized adults with moderate-to- severe atopic dermatitis poorly controlled by topical agents to 12 weekly subcutaneous doses of placebo (n 554) or dupilumab 300 mg (n 555); topical agents were not permitted. Primary efficacy endpoint was percent change in Eczema Area and Severity Index (EASI) score from baseline to week 12. Secondary endpoints included changes from baseline in EASI, body surface area, SCORAD, pruritus numerical rating scale, and 5-D Pruritus Scale; proportions of patients achieving EASI reduction >_50% (EASI-50), Investigator’s Global Assessment (IGA) 0 or 1, and safety were assessed. RESULTS: Baseline characteristics were similar between groups (EASI mean 6SD: 23.12612.35 on dupilumab and 24.10 612.70 on placebo). Percent change from baseline in EASI showed improvements that significantly favored dupilumab relative to placebo, -74.0% and -23.3%, respectively (P< 0.0001). EASI-50 responder rate was 85.5% with dupilu- mab and 35.2% with placebo (P< 0.0001). Other measures of disease activ- ity (SCORAD and IGA) and pruritus scores significantly favored dupilumab (P< 0.0001). Eleven SAEs were reported in the placebo group compared to 1 in the dupilumab group. Skin infections were also reported less often in dupilumab group (2[4%] vs 14[26%]). Treatment-emergent adverse events (TEAEs) were 74.5% with dupilumab and 77.8% with pla- cebo. Frequent TEAEs reported more often with dupilumab were injection site reactions and nasopharyngitis. CONCLUSIONS: In this study, 12 weeks of dupilumab monotherapy was associated with rapid, marked improvements in measures of disease activity and pruritus, fewer SAEs, less infections compared to placebo, and was generally well-tolerated.

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