ImpactFALL 2015 Volume 18 / Issue 3 dana-farber.org and jimmyfund.org THANKING THOSE WHO MAKE A DIFFERENCE

Dana-Farber Cancer Institute has been the top ranked cancer hospital in New England by U.S. News and World Report for 15 consecutive years, and is the only cancer center in the country ranked in the top 4 for both adult and pediatric cancer programs. 3 A Family Tradition 7 Philanthropic Friends

The PMC weekend combines the grit of riding long miles with the generosity and determination of so many people dedicated to conquering cancer. Just like the research and care received by Dana-Farber and Jimmy Fund Clinic patients, the PMC provides a world- class experience. Massachusetts Governor Charlie Baker and Boston Mayor Marty Walsh (bottom, right) were proud to participate in this year’s event alongside 6,000 riders, 4,000 volunteers, and countless supporters along the route. 13 25 Years of Partnership Pan-Mass Challenge raises half-billion dollars for Dana-Farber and the Jimmy Fund since 1980

s the sun rose Aug. 1, more than affected by cancer, and encouraging cheers and and told the audience, “I’m in.” In his address to the 6,000 cyclists from 41 states and eight high-fives. Many riders have lost family members, crowd, Walsh joked that if Baker was in, he was, too. countries gathered to participate in friends, and colleagues to cancer, and even more Mayor Walsh was diagnosed with Burkitt’s the Pan-Mass Challenge (PMC), the ride in honor of those currently in treatment. More lymphoma, a rare form of non-Hodgkin lymphoma, Amost successful athletic fundraising event in the than 600 of the PMC’s cyclists and volunteers are at age 7. He received inpatient care at Boston nation. After rainy conditions in 2014, riders cancer survivors or current patients themselves. Children’s Hospital and outpatient care at Dana- eagerly welcomed bright sunny skies, Farber, and remains cancer-free to this and embarked on treks of up to 192 day. “I would not be standing here miles over one or two days. The if it weren’t for Dana-Farber and the PMC’s mantra, “Closer by the mile,” “The PMC weekend is the best of the human Jimmy Fund,” said Walsh. “All of the propelled riders toward a $45 million condition on display. The dedication and energy real heroes are out there, all of the goal and an incredible milestone— of our PMC riders and volunteers always exceeds survivors, all of the family members.” half a billion dollars in cumulative my expectations. Their commitment to raising Volunteers are critical to the PMC’s fundraising since 1980 benefitting success, and more than 4,000 devoted Dana-Farber Cancer Institute and the extraordinary funds to support cancer research time and effort to prepare and serve Jimmy Fund. inspires me every single day.” food, distribute water, give massages, “The PMC weekend is the best of and provide medical and mechanical the human condition on display,” said ­ — BILLY STARR, PMC Founder and Executive Director, and Dana-Farber Trustee assistance as needed to the riders. PMC Founder and Executive Director The remarkable commitment of so and Dana-Farber Trustee Billy Starr. many generous donors, and nearly 200 “The dedication of our PMC riders and volunteers sponsors including presenting sponsors Red Sox always exceeds my expectations. Their commitment A community of support Foundation and New Balance, and media partner to raising extraordinary funds to support cancer Prominent among the 2015 riders were Massachu- WBZ-TV, enables 100 percent of every rider-raised research inspires me every day.” setts Governor Charlie Baker and Boston Mayor dollar to go to Dana-Farber and the Jimmy Fund. Throughout the weekend PMC riders and Marty Walsh. Both committed to ride a route at “Our partnership with the PMC is truly helping volunteers were constantly reminded why they the PMC’s 2014 “Heavy Hitters Dinner,” an event to make a significant impact in the fight against strived for the unprecedented $45 million goal. held to recognize significant participant fundraising cancer,” said Edward J. Benz Jr., MD, president and Riders were greeted by thousands of spectators achievements. During his remarks, Baker joked that CEO of Dana-Farber. ■ holding signs of gratitude, photos of loved ones he hadn’t been on a bike since he was 18 years old, Dear Friends, Quarterly Update on

You hear from us often about the incredible Government Funding advances in research happening at Dana-Farber Cancer Institute, and their translation into top- at Dana-Farber quality, compassionate patient care. Behind that assertion is a community of real people—dedicated esearchers from Dana-Farber limited treatment options. The results scientists, doctors, nurses, and staff—who are driven Cancer Institute and Brigham of this trial, if positive, could have a by their passion to improve the lives of our patients. R and Women’s Hospital have huge impact on the disease, as we have And surrounding them is an even larger community of individuals, families, received a $10 million Breakthrough estimated that aspirin may save 10,000 organizations, corporations, and foundations, equally driven by their Award from the Department of lives a year in the U.S. and 75,000 lives passion to do whatever they can to support this lifesaving work. Defense to test whether aspirin helps in low-income countries.” Nowhere is this passion more evident than in the committed riders of women with breast cancer avoid The Institute’s success in obtaining our longtime partner, the Pan-Mass Challenge (PMC), who this year made recurrence and live longer. federal grants is a credit to donors a groundbreaking advance of their own. Speeding toward a 2015 goal of “This trial will be the first of its who have the foresight and vision $45 million, they will surpass the phenomenal milestone of a half-billion kind in the United States,” said Eric to fund innovative research aimed dollars in cumulative funds raised for Dana-Farber and the Jimmy Fund Winer, MD, chief of the Division at new ways to combat cancer, and since 1980. of Women’s Cancers, director of the state-of-the-art facilities required This steadfast grassroots support was also exemplified this summer by the Breast Oncology Program, to enable that progress. Investigators generous donors across the country who contributed millions of dollars in and Thompson Chair of Breast must have a proven scientific track the name of cancer research. The WEEI/NESN Jimmy Fund Radio-Telethon Cancer Research at Dana-Farber. record to attain federal funding. The presented by Arbella Insurance Foundation raised more than $3.5 million “The potential benefits of aspirin generosity of philanthropists helps in two days from donors in all 50 states. The national “HomeGoods in preventing breast recurrence are the Institute remain competitive in Helps Families Fight Cancer” campaign raised $1.4 million, exceeding significant and we look forward this marketplace, and recruit and the $1 million mark for the second year in a row. And in its 25th year to determining if aspirin could retain world-class faculty members of partnership with Dana-Farber and the Jimmy Fund, the Stop & Shop augment current therapies. This is a whose contributions span multiple Supermarket Company and its Our Family Foundation once again raised treatment that needs to be evaluated fields of cancer research. ■ $2.5 million. further,” emphasized Winer, who is The grant reported in this publication Foundations and philanthropic individuals are also driving innovation a partnering principal investigator of was supported by the Department of Defense’s throughout the Institute. A tremendous $1.5 million grant from The the grant. Office of the Congressionally Directed Medical Lustgarten Foundation is helping to launch a comprehensive study to define In the U.S., the pharmaceutical Research Program. new prevention and treatment strategies for pancreatic cancer. American industry plays a significant role Cancer Society grants and professorships totaling more than $5.1 million in sponsoring cancer treatment, are supporting research in a wide range of cancers and related areas such but there has been little industry as treatment disparities and adherence. And Robert “Robin” McGraw and incentive to fund a large-scale trial the Donald C. McGraw Foundation furthered the family’s longstanding using aspirin, which is generic and commitment to Dana-Farber with a $1 million gift to expand treatment widely available over the counter. The options for head and neck cancers. Department of Defense Breakthrough Since its inception, Dana-Farber Cancer Institute has placed an emphasis Award is a unique mechanism that on cancer research and its applications to improve cancer outcomes. This supports studies like the Aspirin for commitment means that research is prominent in all of the Institute’s Breast Cancer trial, which would be strategic decisions. The creation of a Faculty Research Fund in 2013 was an unlikely to receive funding through institutional initiative designed to help Dana-Farber achieve its ambitious traditional industry sources. research agenda. Since the launch of the Faculty Research Fund, 10 percent “Although chemotherapy and of all new restricted gifts have been placed in the Fund, which is especially hormonal therapies have helped important as federal funding for cancer research remains on the decline. women with breast cancer live longer, Gifts totaling $3.7 million to the Faculty Research Fund received in 2014 they are expensive and have many were applied this year to the Longwood Center, allowing the project to side effects,” said Wendy Chen, MD, open successfully in January 2015. These monies bolstered the Institute’s MPH, a senior physician at Dana- investment in cancer biology, chemistry, and drug discovery, as well as in Farber’s Susan F. Smith Center for attracting and retaining the very best physician-scientists in the world. Women’s Cancers and co-investigator Wendy Chen, MD, MPH, will lead research funded by a $10 million In fiscal year 2015, gifts to the Faculty Research Fund totaled of the study. “Women whose tumors Department of Defense grant. $3.8 million. These funds will be applied to Dana-Farber’s initiatives in are not sensitive to hormones have immunotherapy, genomics, and leukemia to advance cancer treatments for patients. This allocation is pivotal to the Institute’s investment in therapeutic strategies that provoke an immune response against cancer, target the causes of gene mutations, and employ collaborative research approaches as precision cancer care expands its scope. As you will note in the quarterly update at right, Dana-Farber Cancer Institute continues to be a leading recipient of federal grants. But federal funding even at its highest does not support our entire agenda for research and care. Your generous gifts fill that gap and fuel our ambitious mission to conquer all forms of cancer. Thank you for the powerful difference you are making in the lives of adults and children with cancer, here in Boston and around the globe.

Sincerely, APRIL 2 • 2016

Learn more today at JimmyFundDanceParty.org

Susan S. Paresky #JimmyFundDanceParty Senior Vice President for Development

2 Impact | FALL 2015 Thank you for supporting Dana-Farber and the Jimmy Fund!

McGraw Family continues legacy of support with $1 million gift to accelerate head and neck cancer discoveries

hen Robert “Robin” furthering that legacy,” said Haddad. McGraw was faced with “Head and neck cancers attract W the decision about where limited funding for research, making to receive his cancer care, he knew philanthropic support vital to propel where to turn. The McGraw Family discoveries. Robin’s generosity will has long supported Dana-Farber, be transformational in helping us to including Robin’s mother, who was elucidate the alterations driving these passionate about raising money malignancies, identify new drugs, and to improve early detection and deliver more effective treatments.” treatment of breast cancer. The Robin carefully considered how family’s foundation, the Donald best to help overcome the challenges C. McGraw Foundation, Inc., also in treating head and neck cancers,

previously funded a fellowship many of which are rapidly increasing Robin McGraw (left, pictured in the Dana-Farber lab coat given to Aesclepian Society at Dana-Farber and established in incidence. Recognizing the members) recently made a tremendous $1 million gift to establish the McGraw Family Fund for Head and Neck Cancer Research under the direction of Robert Haddad, MD, the McGraw/Patterson Center for importance of discovery science disease center leader of Dana-Farber’s Head and Neck Oncology Program. Population Sciences, named for and the need for more funding in the physician who treated Robin’s this disease, Robin chose to support mother. Haddad and his colleagues as they could be made.” “The team approach at Dana-Farber Inspired by his care at Dana-Farber strive to understand the biological Long dedicated to the fields of made a huge difference and helped and the need for additional treatment mechanisms linked to these tumors, medicine and health care, Robin me to stay positive,” said Robin. In options, Robin and the McGraw which could improve early diagnosis is a retired paramedic and former addition to Haddad and Roy Tishler, Foundation recently made a and inform the delivery of targeted medical captain of the Egremont MD, PhD, the director of Head and $1 million gift to establish the treatments. Fire Department. He also holds Neck Radiation Oncology, he added, McGraw Family Fund for Head and “Research is the key to ending leadership roles in medical research “the entire team at Dana-Farber was Neck Cancer Research under the all of this. The more money that’s organizations, including the National great, including my nutritionist, my direction of Robert Haddad, MD, invested in research, the better chance Multiple Sclerosis Society. While his speech therapist, my acupuncturist, disease center leader of Dana-Farber’s we have,” said Robin. “I wanted to philanthropic interests are many, and my wonderful nurse practitioner, Head and Neck Oncology Program. make a significant contribution to Robin recognized that his support of Jason Glass. I’m so proud to be able “The McGraw Family has been the current progress in head and Dana-Farber would not only drive to help advance their work, and hope tremendously supportive of Dana- neck cancer treatment, and I put my research, but also contribute to the that others are inspired to support this Farber, and this meaningful gift is money where I felt the most impact Institute’s signature, total patient care. lifesaving research.” ■

Avon Foundation closes the funding gap in metastatic New imaging facility will propel breast cancer precision cancer research The opening of the Molecular Cancer Imaging Facility (MCIF) at Dana-Farber’s t is estimated that up to 250,000 to receive one of their prestigious Harbor Campus in June marked a pivotal shift for research in precision cancer people are living with metastatic research grants. medicine. breast cancer (MBC) in the U.S., “The Metastatic Breast Cancer I Made possible in part by a visionary $10 million grant from the Massachusetts yet, over the last decade, only 7 Alliance issued a Landscape Report Life Sciences Center (MLSC), a state-funded agency that supports life sciences percent of breast cancer research last fall that identified the lack of innovation, research, development, and commercialization, the MCIF is home investments have been dedicated to effective lab models as a factor that to the only cyclotron in New England dedicated to cancer research. The MBC. With no cure available, and impedes progress in developing new cyclotron generates short-lived molecular imaging probes that are tracked by 40,000 Americans dying of MBC treatments for MBC,” said Carolyn PET scanners, enabling researchers to assess the effectiveness of treatments each year, the Avon Foundation for Angeleri Ricci, program director at the within days instead of weeks or months. Women has made MBC research a Avon Foundation for Women. “Dr. “The MCIF cyclotron will allow our scientists to create the tools needed to funding priority, and has chosen Mitsiades’ project directly addresses identify the precise molecular and genetic abnormalities that drive cancer,” Dana-Farber’s Constantine Mitsiades, this gap as it proposes to develop a said Barrett Rollins, MD, PhD, chief scientific officer at Dana-Farber. MD, PhD, and Eugen Dhimolea, PhD, new laboratory model to study MBC.” Cutting the ribbon at the MCIF opening were (below, from left) Huy The Avon Foundation hopes Nguyen, MD, interim executive director and medical director of the Boston their $125,000 grant will help Public Health Commission; Angus McQuilken, MLSC vice president for Mitsiades and Dhimolea, a member communications and marketing and a former Dana-Farber patient; Barrett of Mitsiades’ lab and co-investigator Rollins; and Edward J. Benz Jr., MD, Dana-Farber president and CEO. on this grant, answer significant questions in treating MBC. “With support from the Avon Foundation, we will be able to develop a system to determine how breast cancer cells spread and how some breast cancer cells are protected from the effects of chemotherapy,” Former Avon Foundation Executive said Mitsiades. “We hope that by Director Marc Hurlbert, PhD (far understanding more about these left) and President Cheryl Heinonen present a ceremonial check to Dana- mechanisms and processes we can Farber’s Constantine Mitsiades, MD, significantly improve our ability PhD (second from right) and Eugen Dhimolea, PhD. to treat MBC and improve patient outcomes.” ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 3 Make your gift online at Dana-Farber.org/give

WEEI/NESN Jimmy Fund Radio-Telethon tops $3.5 million

better displayed than during the two days of the Jimmy Fund Radio- Telethon,” said Phil Zachary, vice president and market manager at Entercom Boston, parent company of WEEI. “It’s humbling for us at WEEI to witness our audience respond to the In the early hours of Aug.18, dozens impassioned and persuasive pleas of of volunteers, participants, and Dana-Farber patients and staff, and to radio and television crews arrived know that in some small way we’re a at Fenway Park to kick off the 14th part of their caring community.” The Boston Red Sox turned out in force to support Dana-Farber patients and families at annual WEEI/NESN Jimmy Fund Highlights from the event included the WEEI/NESN Jimmy Fund Radio-Telethon presented by Arbella Insurance Foundation. Radio-Telethon presented by Arbella interviews with New England sports Insurance Foundation. The 36-hour team principal owners John Henry of event, broadcast live by New England the Boston Red Sox; Robert Kraft during the pre-game ceremony, fans Sports Network (NESN) and WEEI of the New England Patriots and the were able to hear the incredible story Sports Radio Network (93.7 FM), New England Revolution, who is of a Dana-Farber stem cell recipient featured inspiring stories from Dana- also a Dana-Farber Trustee; Charlie who was meeting his donor inperson Farber patients, doctors, researchers, Jacobs of the Boston Bruins; and Wyc for the first time on field. Their story and nurses, and raised $3.5 million. Grousbeck of the Boston Celtics. was made even more impactful Members of the Boston Red Sox Boston Bruins Jimmy Hayes, Torey as they threw out the first pitch stopped by throughout the event to Krug, Tuukka Rask, and former Bruin together. snap photos and talk with patients, Shawn Thornton also appeared to On Day Two, Mark Giove, the speak on air, and make personal gifts. encourage the audience to make gifts. father of a Jimmy Fund Clinic patient, Patients and family members New England Patriots quarterback beautifully sang the National Anthem, shared their personal stories of Tom Brady texted in his generous while Jimmy Fund Clinic teenagers struggle and triumph after receiving a $50,000 gift. who attended this year’s Spring cancer diagnosis, demonstrating the There was also plenty of activity Training Trip were featured during the critical importance of the funds raised before and during the games each pre-game show. Two of those teens through the Radio-Telethon, and night of Radio-Telethon. On Day were chosen to throw out the first encouraging listeners and viewers to One, the Boston Red Sox Jimmy Fund pitch during that night’s game. join the mission to give. Award was given to Robert Brack for Phones kept ringing until late into Dana-Farber patients like Robyn “At its core, sports talk radio is his work to support ovarian cancer the night of Aug. 19, with donors call- Nash shared their personal stories to encourage people to give to this year’s about passion, persuasion, and, above research, as well as a number of other ing from all 50 states, pushing the 14- Radio-Telethon. all, community, and nowhere is that worthy causes at Dana-Farber. Also year total past the $40 million mark. ■

Terri Brodeur Breast Cancer Foundation drives research

nspired by the life and memory Farber researchers Eugen Dhimolea, of Terri Brodeur and Norma PhD, and Nina Ilic, PhD. Dhimolea I Logan, the Terri Brodeur will use laboratory models to study Breast Cancer Foundation has the relationship between the bone supported breast cancer research metastatic microenvironment and for over a decade. The foundation’s the evolution of malignant cell activities—including its Walk Across populations in relation to resistance Southeastern Connecticut, which to antiestrogens, a common post- recently celebrated its milestone 10th operative treatment for patients with anniversary—are led by a committed estrogen receptor (ER)-positive breast core of volunteers who support cancer. Dhimolea’s research will help promising young investigators in New to reveal why breast cancer metastatic England and beyond. lesions do not respond to treatment. “Music Heals the Soul” hits a In 2015, the foundation awarded Ilic is examining mutations to the two $100,000 fellowships to Dana- PIK3CA gene, which promotes the high note for the Zakim Center growth of approximately 30 percent of all breast cancer tumors. She will in- The 8th annual “Music Heals the Soul” event held May 12 at the vestigate specific metabolic vulnerabil- InterContinental in Boston hit a high note, raising a phenomenal $775,000— more than three times the previous year—to support the Leonard P. Zakim ities in PIK3CA-mutant breast cancers, Center for Integrative Therapies at Dana-Farber, pushing the event’s which she recently discovered, to see if cumulative fundraising past the $1 million milestone. The night celebrated these targets represent new opportuni- the Zakim Center’s 15th anniversary and brought together more than 600 ties for treatment. guests for an evening of music and healing emceed by WCVB-TV’s Kelley “We direct 100 percent of the Tuthill, a cancer survivor herself. funds we raise directly to research,” Guests enjoyed live performances from local musicians, delicious food, and said Michael Morin, PhD, a member demonstrations of therapies from the Zakim Center, including massage, Dana-Farber’s Eugen Dhimolea, PhD of the organization’s Scientific (left) and Nina Ilic, PhD (right) with Advisory Committee. “For many acupuncture, and creative arts. (from left) the foundation’s Patricia The evening honored Harold and Linda Schwartz (above), longtime friends Newborg, board secretary and 10th young investigators, this support is a Anniversary Walk Across Southeastern lifeline for their career development. and benefactors of the center, and Angela Menino, whose late husband, Connecticut chair; Sandy Maniscalco, former City of Boston Mayor Tom Menino, was a Dana-Farber patient who co-founder and interim executive As NIH funding decreases, it’s utilized the services of the Zakim Center. director; Howard Brensilver, MD, board important for us to step in—we can’t vice president; and Mike Morin, PhD, afford to let such critical research Scientific Advisory Committee member. unravel.” ■

4 Impact | FALL 2015 Intel Corporation advances imaging technology for immunology and AIDS research

ntel Corporation has made a of structural biology, computation concerted effort to optimize chemistry, biophysics, and bioinfor- I software and computational tools matics to solve problems which were necessary to accelerate scientific not possible even six months ago,” discovery. As part of this effort, Intel said Brian Napier, validation engineer awarded a gift to Youdong Mao, at Intel. “Cryo-eletron microscopy PhD, of Dana-Farber’s Department of allows visualization of subcellular Cancer Immunology and Virology. structures and complex proteins at Intel’s gift will enable Mao to apply the atomic level, without the harmful cryo-electron microscopy to cancer effects of radiation which damage immunology and AIDS research to sensitive biological structures. study the structure of protein at an Youdong Mao is applying this very Robert Brack receives atomic level. Protein structures can technology in cancer immunology be used to design new cancer-fighting and AIDS research.” ■ Jimmy Fund’s highest honor drugs, guide the development of mo- On Aug. 18, the Boston Red Sox presented Robert B. Brack with the 2015 lecular medicine and treatments, and Boston Red Sox Jimmy Fund Award, the Jimmy Fund’s highest honor, in create a template to design vaccines recognition of his longstanding commitment to Dana-Farber and the Jimmy that can prevent infectious diseases. Fund’s lifesaving mission. “Intel’s gift allows us to directly In 1999, Brack’s wife, Joan, passed away from ovarian cancer. To honor her visualize individual molecules at memory and the compassionate care she received at Dana-Farber, the Brack the finest level that are involved in family established the Joan H. Brack Family Foundation, which supports cancers and diseases and are heretofore ovarian cancer research under Ursula Matulonis, MD, interim director of unseen,” said Mao. “Intel not only Dana-Farber’s Susan F. Smith Center for Women’s Cancers and medical provided research funds, but also sent director of Gynecologic Oncology. Along with his dedicated committee, their highly experienced software Brack also organizes the annual Joan H. Brack Memorial Golf Tournament, engineers to assist with the state-of- which has cumulatively raised more than $1.7 million since 2000.

the-art parallel computer technology.” Above, Boston Red Sox President/CEO Emeritus and Institute Trustee Larry Youdong Mao, PhD, is exploring “Molecular imaging represents the Lucchino (left) with Robert Brack during the presentation ceremony at proteins at the atomic level with a gift next grand challenge for life scienc- from Intel Corporation. Fenway Park. es, bringing together the disciplines

Bill and Lynne Gillen fuel The Herb Chambers Automotive lung cancer research with Family named official partner of new $100,000 gift Dana-Farber and the Jimmy Fund

n 2007, Institute Trustee Bill Gillen “While our most effective he Herb Chambers Automo- In addition to its financial contri- and his wife, Lynne, established tools for treating lung cancer are tive Family, based in Boston, bution, Herb Chambers dealerships I the James B. Gillen Thoracic prevention and early detection, this T has been named the Official have hosted a number of initiatives Oncology Research Fund in honor gift will help us to develop targeted Automotive Family of Dana-Farber throughout the past year to increase of Bill’s father, who lost his battle immunotherapies for today’s Cancer Institute and the Jimmy awareness and funding for Dana- to lung cancer in 1978. Since then, patients while changing the odds for Fund with gifts totaling $225,000. Farber. Among these were a month- the fund has supported research at patients in the future,” said Jänne. “It is a privilege to partner with long in-store fundraising campaign, Dana-Farber’s Carole M. and Philip L. Longtime supporters of Dana- Dana-Farber and the Jimmy Fund, and promotion and sales of the Lowe Center for Thoracic Oncology, Farber Cancer Institute, Bill and and we couldn’t have aligned popular Boston Red Sox/Jimmy Fund which is currently overseen by Pasi Lynne are also model ambassadors ourselves with a more worthy cause,” License Plate to the purchasers of new Jänne, MD, PhD. Recently, the Gillens for Dana-Farber’s mission. They said Herb Chambers, president and pre-owned vehicles. ■ generously gave another $100,000 to have participated in many Institute and CEO of The Herb Chambers continue their support of the fund. and Jimmy Fund events, along with Automotive Family. “Conquering speaking about their experience cancer is a goal that we share with with lung cancer. Dana-Farber, and it is my hope “This renewed gift is a sign of that this partnership will afford our continued confidence in the our team members, clients, and the thoracic team and the leadership of community with an opportunity to Dr. Jänne,” said Bill Gillen. “We are make a significant difference.” at a point now where the pace of As part of the partnership, The discovery is accelerating. The return Herb Chambers Automotive Family on investment is greater than it has has signed on as a sponsor at several ever been. The dedication of the Jimmy Fund events and programs, researchers and staff at Dana-Farber including Jimmy Fund Golf, Jimmy and the Lowe Center is extraordi- Fund Scooper Bowl® presented by nary and they deserve our support. Walgreens, WEEI/NESN Jimmy Fund Herb Chambers, president and CEO Institute Trustee Bill Gillen and wife, I have seen the collaboration within Radio-Telethon presented by Arbella of The Herb Chambers Automotive Lynne, made a new gift to the James the Institute, and believe that the Insurance Foundation, and UnMask Family, enjoys a light moment with B. Gillen Thoracic Oncology Research Jimmy Fund Clinic patient Ali and her Fund. discoveries in thoracic will benefit a Cancer presented by Mandarin mom, Amanda. wide range of disease centers.” ■ Oriental, Boston.

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 5 Strianese and Schwartz families rally to conquer esophageal cancer

hen Ken Schwartz was physician-scientists to learn more Research—and, with Ken’s wife, Julia, investment is vital to continuing our diagnosed with esophageal about esophageal and gastric cancer— created a Giving Page online to enable progress in conquering esophageal W cancer earlier this year, his and the vital need for research others to support the fund. cancer,” said Enzinger. “Their entire family rallied by his side with funding. Inspired to fulfill that need, And their support does not support will enable us to pursue love, support, and a shared mission: Ken’s daughter and son-in-law, Alyson stop there. Alyson and Julia raised groundbreaking research that will partner with Dana-Farber Cancer and Michael T. Strianese, made a funds as virtual riders in the Pan- transform how we treat this disease Institute to conquer the disease. $500,000 gift to Dana-Farber to Mass Challenge, and Ken’s other and dramatically improve the lives of During his treatment, Ken and establish the Schwartz and Strianese daughter, Karly Servais, participated patients.” his family met with Dana-Farber Family Fund for Esophageal Cancer in the Boston Marathon® Jimmy Most recently, Enzinger and Fund Walk presented by Hyundai. his team conducted a clinical trial All three are involved in forming an demonstrating increased survival advocacy group for Dana-Farber’s and response rates among metastatic Center for Esophageal and Gastric esophageal cancer patients with the Cancer with other Boston-based HER2 gene who were treated with families, and Alyson has joined Dana- the standard drug combination along Farber’s Visiting Committee for the with the drug bevacizumab. Gastrointestinal Cancer Center. “It was important for our family The Strianeses’ fund will support to take an active role in fighting this research led by Peter Enzinger, MD, disease,” said Alyson. “By investing in Alyson and Michael Strianese (right) established the Schwartz and Strianese Family director of the Center for Esophageal research at Dana-Farber, we can make Fund for Esophageal Cancer Research in honor of Alyson’s father, Ken Schwartz and Gastric Cancer, who treated Ken a significant impact on finding new (center). They are pictured above with (from left) Ken’s daughter Karly Servais, Dana- Farber’s Adam Bass, MD, Ken’s wife, Julia Heskel, and Ken’s doctor, Peter Enzinger, MD. before his passing in September. therapies—and ultimately a cure for “Alyson and Michael’s generous patients with esophageal cancer.” ■

New grants from Ovarian Cancer Research Fund support early-career investigators

ifficult to detect, and with no available chair and board member. “We continue to award enable my work to better understand the molecular screening test, ovarian cancer is an elusive ovarian cancer research grants to this leading cancer events that underlie ovarian cancer, develop better D disease that is often caught only once it has institution, which serves as a testament to the caliber models to study ovarian cancer, and identify novel spread. Through investment in research, Ovarian of its investigators, and we look forward to seeing therapeutic strategies for targeting this disease.” Cancer Research Fund seeks to better understand, the results of their important work in the field.” In addition to this support, Ovarian Cancer identify, treat, and ultimately cure ovarian cancer. Ovarian Cancer Research Fund granted Sarah Research Fund granted Ann Schreiber Mentored Continuing a longstanding relationship with Dana- Walker, PhD, a Liz Tilberis Early Career Award for Investigator Awards to Zeina Kais, PhD, and Farber, Ovarian Cancer Research Fund recently $450,000. Ovarian Cancer Research Fund’s steadfast Nicole Spardy, PhD. Kais is investigating a novel awarded a total of $600,000 in grants to three early- dedication to invigorating the careers of these approach to treating a unique subtype of high- career investigators. investigators catalyzes their promising research, grade serous ovarian cancer by targeting two “The quality of proposals received and grants helping make new breakthroughs that may change different mechanisms that contribute to resistance funded by Ovarian Cancer Research Fund increase patient care. to chemotherapy. Spardy is identifying new genetic every year, and those from Dana-Farber are no “This support from Ovarian Cancer Research dependencies in ovarian cancers that lack a certain exception,” said Jeff Boyd, PhD, Ovarian Cancer Fund has a tremendous impact on my career as type of DNA repair mechanism, which can be Research Fund’s Scientific Advisory Committee an investigator,” said Walker. “This grant will help caused by BRCA1 or BRCA2 gene mutations. ■

A Chance For Kids & Families® is a win-win for everyone

conquer cancer at Dana-Farber The Burger King franchise community, Cancer Institute. Paul Caprino, a our employees, and vendor partners bike messenger from Somerville, are proud to help this effort through Mass., was inspired to give because A Chance for Kids & Families.” his girlfriend lost her father to cancer Customers who contributed $1 to when she was a child. “This is a way the Jimmy Fund received a scratch to support cancer research,” said card and won a prize provided by a Caprino. “And small amounts can corporate sponsor. Prizes included really add up.” a TNT Vacations trip powered by Small amounts do add up: this Funjet Vacations, American Airlines year’s promotion raised more than AAdvantage® miles, a hot tub from $570,000. Since the program began New England Spas, a Sea-Doo® as a partnership between Burger personal watercraft, a shed from Reeds King and the Jimmy Fund in 2000, A Ferry Sheds®, and tickets to Blue Man Chance for Kids & Families has raised Group Boston, Six Flags New England, over $13.3 million. Valvoline Instant and Water Country. From July 27 through Sept. 6, Oil Change joined the effort in 2014. Caprino’s ticket yielded a Whopper customers who visited Burger King® “Cancer has touched so many Jr.® with cheese, which he redeemed Jimmy Fund Clinic patient Sophie or Valvoline Instant Oil Change lives,” said Jim Froio, Burger King while between deliveries at the Center Gagnon (left), her mother, Patricia, father, Marc, and little sister, Lucy, and paid $1 for an A Chance for franchisee. “The work being done Plaza Burger King in downtown supported A Chance for Kids & Families Kids & Families® scratch card won at Dana-Farber is helping to rid this Boston. ■ by appearing on promotional materials. a prize and helped the Jimmy Fund devastating disease from the world.

6 Impact | FALL 2015 Create your own Giving Page at myjimmyfundpage.org

American Cancer Society awards more than $5.1 million to Dana-Farber investigators • Rachel Freedman, MD, MPH, to • Samuel McBrayer, PhD, to investigate longtime supporter of grateful to be an American Cancer examine disparities in breast cancer the functional effects of a mutant Dana-Farber, the American Society Clinical Research Professor,” knowledge and treatment adherence; enzyme in glioma; and ACancer Society (ACS) recently said Anderson. “It helps to support bestowed two of its most prestigious development of novel therapies and • Cigall Kadoch, PhD, to identify • Xiao-Feng Zheng, PhD, to examine honors on investigators Kenneth mentoring of the next generation of small-molecule-based therapeutics to the dysregulation of a tumor Anderson, MD, and Matthew Meyer- researchers and caregivers, ultimately treat human synovial sarcoma; suppressor gene implicated in lymphoma and breast cancer. son, MD, PhD, among 11 ACS grants leading to new and more effective • Rachel Kubiak, PhD, to structurally to Dana-Farber investigators totaling treatments for patients and their characterize protein complexes “The advances made by Dana- more than $5.1 million. families.” implicated in tumor suppression and Farber investigators are being Anderson, director of Dana-Farber’s Meyerson’s professorship supports identify small molecules capable of translated into improvements for Jerome Lipper Multiple Myeloma genome-inspired approaches to lung stabilizing these complexes; cancer patients around the world,” Center and LeBow Institute for cancer discovery and therapeutics. said Peg Camp, ACS executive vice • Jennifer Mack, MD, MPH, to examine Myeloma Therapeutics and the Kraft “I am extremely grateful for this Amer- president and New England Division difficult parent-physician relationships Family Professor of Medicine, received ican Cancer Society professorship,” operating officer. “We are proud to in pediatric oncology; a renewal of his 2010 Clinical said Meyerson. “This grant will help support these talented scientists in Research Professor Award. Meyerson, us to generate innovative approaches their quest to cure cancer.” ■ co-director of the Center for Cancer to the prevention, management, and Genome Discovery, earned a Research treatment of lung cancer, which is a Professor Award. major global public health problem.” ACS Research Professorships pro- In addition, nine Dana-Farber vide flexible funding for investigators investigators earned ACS research who have made seminal contribu- grants: tions to cancer research and provide • Gregory Abel, MD, MPH, to study leadership in their research area. the effectiveness of new treatments for Clinical Research Professorships are myelodysplastic syndromes; awarded to scientists who have made • Adam Bass, MD, to enhance therapy significant contributions in the area for gastroesophageal adenocarcinoma of cancer control that have changed driven by mutations to the ERBB2 gene; the direction of clinical, psychosocial, behavioral, health policy, or epidemi- • Curtis Chong, MD, PhD, to accelerate ologic cancer research. drug discovery for patients with Anderson’s award funds research EGFR-mutant lung cancer who have Kenneth Anderson, MD (left), and Matthew Meyerson, MD, PhD, received two of the on new therapies to treat multiple developed resistance to standard American Cancer Society’s most prestigious professorship awards. myeloma. “I am highly honored and treatments;

John Hancock Fenway Fantasy Friends of Dana-Farber Cancer Day participants step up to the Institute rise to the occasion plate for the Jimmy Fund The Friends of Dana-Farber Cancer Institute held their annual spring gala, this year entitled “RISE: An Evening to Celebrate the Power of Mentorship,” n June 27, more than 2,000 earned the opportunity to play on the Friday, May 1, at the Four Seasons Hotel in Boston. Nelly Carreño, three-time participants and fans gathered field during the event. Emmy award-winning NECN meteorologist, emceed the event, and special O at historic Fenway Park to “John Hancock is honored to honoree and Boston-based chef Gordon Hamersley spoke on the power of live out their baseball dreams and support Dana-Farber and the Jimmy mentorship. The night provided fine dining and an auction with unique fight cancer at John Hancock Fenway Fund through this event,” said Rob items for all interests. More than $500,000 was raised in support of various Fantasy Day to benefit the Jimmy Friedman, assistant vice president of research, treatment, and patient programs at Dana-Farber. Below, 2015 Fund. This year, presenting sponsor Sponsorship and Event Marketing Friends of Dana-Farber Co-Presidents Jennifer Cunningham Butler (left) and John Hancock and Fantasy Day at John Hancock. “We maintain a Debbie Maltzman, at the event. participants knocked cancer out of longstanding commitment to the Established in 1976, the Friends of Dana-Farber Cancer Institute is an all- the park, raising more than $200,000 communities in which we live and volunteer group of more than 1,200 members united by a shared dedication for Dana-Farber Cancer Institute’s work, and we are particularly proud of to the fight against cancer. In addition to their fundraising efforts, the patient care and research initiatives— our partnership with Dana-Farber and Friends also volunteer throughout the Institute. bringing the event’s cumulative the Jimmy Fund as we work together fundraising total to more than to conquer cancer.” ■ $7.5 million since 1992. Jimmy Fund supporters could fundraise their way onto the field, purchase individual or corporate hospitality packages, or contribute by sponsoring a patient—creating an opportunity for adult and pediatric cancer patients to enjoy a memorable day of batting and fielding fun. This year also marked the start of the High School All-Stars, a program for baseball and softball teams to fundraise and sponsor patients, as well. The top three fundraising teams

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 7 Impact is available online at JimmyFund.org/Impact

The Lustgarten Foundation grant of $1.5 million fuels groundbreaking pancreatic cancer research

cancer, and thereby develop new therapeutic Preclinical testing is critical in determining which approaches based on those critical biologic therapeutic options may be effective at halting discoveries. We are grateful to have the foundation cancer’s growth and development, and is an as a partner on our mission to improve outcomes important first step before investigators can move for men and women with this disease.” their work into the clinic. In a previous study of more than 300,000 “Cancer of the pancreas is the most lethal cancer The Lustgarten Foundation recently awarded healthy patients, Fuchs and his collaborators there is—it is difficult to detect and hard to treat,” a generous grant of $1.5 million over three determined that traits such as obesity and diabetes said Kerri Kaplan, executive director and chief years to Charles Fuchs, MD, MPH, director of can increase an individual’s risk of developing operating officer of The Lustgarten Foundation. the Gastrointestinal Cancer Center and the pancreatic cancer—but the mechanisms that “Research is our best weapon in the fight against Robert T. and Judith B. Hale Chair in Pancreatic lie behind this relationship remain a mystery. this deadly disease, and we remain committed Cancer at Dana-Farber Cancer Institute. This The grant funding will be shared with Mandar to collaborating with and supporting expert tremendous award, which will help Fuchs launch Muzumdar, MD, a member of Dana-Farber’s investigators like Dr. Fuchs to find better treatment a comprehensive study to define new targets for gastrointestinal faculty, and the team will use options and offer new hope to patients and their prevention and treatment of pancreatic cancer, sophisticated laboratory models to investigate families.” exemplifies the organization’s commitment to how obesity contributes to the spread of this Founded in 1998, The Lustgarten Foundation is fueling the most promising studies across the disease. By studying various types of blood and America’s largest private funder of pancreatic cancer United States and advancing efforts that may lead tumor specimens, the researchers hope to gain research. The foundation is devoted to finding a to new breakthroughs. new insights into how pancreatic cancer forms in cure, facilitating dialogue within the medical and “While we have made some progress in the the body—knowledge that may help to reveal new scientific community, and educating the public treatment of pancreatic cancer, there is an urgent targets for therapy. about this lethal disease, which affects nearly need to define new, more effective therapies,” Building upon their findings, the team will then 49,000 people in the United States each year. ■ said Fuchs. “In the years ahead, we seek to better conduct tests in the laboratory aimed at inhibiting understand the biologic drivers of pancreatic the most promising new targets that they uncover.

The scoop on Scooper Bowl® Terrana’s passion for

Ice Cream®. Attendees also posed for Dana-Farber propels photos with a special Scooper Bowl photo frame and shared them with translational research their social media followers and Presented by friends using #ScooperBowl. eth Terrana has made a “Walgreens was proud to support $100,000 gift to support the At the 33rd annual Jimmy Fund the Jimmy Fund Scooper Bowl as B work of Eric Winer, MD, Scooper Bowl® presented by the presenting sponsor again this chief of the Division of Women’s Walgreens, ice cream lovers devoured year,” said Tyler Hough, director Cancers, director of the Breast more than 8,000 gallons of ice of Pharmacy and Retail Operations Oncology Program, and Thompson cream and 24,000 frozen novelties at Walgreens. “With over 140 local Chair in Breast Cancer Research at on Boston’s City Hall Plaza June 2-4. store team members volunteering Dana-Farber. An Institute Trustee, The nation’s largest all-you-can-eat more than 500 hours at the Terrana was inspired by the medical ice cream festival raised more than event, we were able to show our advances being made, and by the $463,000 to support Dana-Farber alignment with Dana-Farber and passionate commitment of the Cancer Institute and the Jimmy Fund. the Jimmy Fund. It is a rewarding doctors, researchers, and fellows she Thousands braved the rain and way for Walgreens to give back to has encountered during her years of heat to enjoy delicious treats provid- an organization that builds a strong, involvement with Dana-Farber. ed by the nation’s top ice cream and happy, and healthy community and “When you look at Dana-Farber’s frozen yogurt companies, including helps us with our purpose to help patient care and research, the work Beth Terrana has made a $100,000 gift ® ® Baskin-Robbins , Ben & Jerry’s , Brey- people get, stay, and live well.” is outstanding,” said Terrana. She is to support the work of Dr. Eric Winer. ers®, Delish™ by Walgreens, Edy’s®/ Since 1983, the Jimmy Fund also a co-founder, former co-chair, Nestlé, Friendly’s®, Hood®, Orange Scooper Bowl has raised more than and current member of the Susan F. Leaf® Frozen Yogurt, and Yuengling’s $5 million. ■ Smith Center for Women’s Cancers “When you look Executive Council and a member at Dana-Farber’s of the Susan F. Smith Center for Women’s Cancers Visiting patient care and Committee. research, the work “From the first day I was involved is outstanding.” with Visiting Committee, I have been overwhelmed by the research- —BETH TERRANA, Institute Trustee ers and the clinicians involved with the program,” said Terrana. “Not just because they are brilliant, but because they are so dedicated. I translational investigator who is called Dr. Winer after a meeting and conducting experiments in the asked, ‘What can I do?’” laboratory and the clinic to improve “Beth Terrana’s gift will fund the care for women with advanced research conducted in HER2- HER2-positive breast cancer who have positive breast cancer,” said Winer. already experienced a worsening of In the company’s second year as presenting sponsor, Walgreens employees enthusiastically volunteered their time in support of the Jimmy Fund Scooper Bowl. “In particular, the gift will support their cancer in spite of the standard Shom Goel, MD, PhD, a young treatments.” ■

8 Impact | FALL 2015 Crowleys support innovative melanoma research

ongtime contributors Jane and therapies for the people and families Brian Crowley have established that may be affected by this disease L a fund to support the melanoma now and in the years to come,” said investigations of F. Stephen Hodi, Brian. “There have been a tremendous MD, director of both the Melanoma number of advancements made Center and Center for Immuno- in the fight against melanoma at Oncology and the Sharon Crowley Dana-Farber and we’re proud to be Martin Chair at Dana-Farber. associated with that work.” “We have seen the problems Last year, the drugs pembroli- associated with melanoma and want zumab and nivolumab, which were Granite Telecommunications, to help in the development of new tested extensively at Dana-Farber, were the first in a new class of LLC, builds solid support for immunotherapies approved by the FDA for patients with advanced Dana-Farber melanoma. Called PD-1 inhibitors, these therapies unleash the immune For more than a decade, the Hale family has been committed to advancing system’s natural anti-tumor response. Dana-Farber’s mission through fundraising events that engage their company, Granite Telecommunications, LLC, and the community. Additionally, Hodi led a study that extended survival in patients with Each June, the company turns the parking lot of its Quincy, Mass., metastatic melanoma by 50 percent headquarters into a carnival for its annual Granite Day celebration, which with a combination of immune ther- attracts more than 8,000 local residents. Held in memory of company apies. He looks forward to continued founder, Robert Hale Sr., who passed away from pancreatic cancer in 2008, this year’s event raised more than $550,000 to support the Hale Family Center progress in the Melanoma Center’s for Pancreatic Cancer at Dana-Farber. immunotherapy studies. “With the generous support of the Granite also hosted its second “Saving by Shaving” event April 7 at the Crowleys, we will be able to pursue company’s headquarters. Governor Charlie Baker and Quincy Mayor Thomas Koch joined more than 500 Granite employees to help raise $3.25 million for areas of investigation that would Dana-Farber. otherwise take much longer or not happen at all,” said Hodi. Above (from right), Granite CEO Rob Hale, his wife, Karen, and his mother, “Dr. Hodi certainly has shown that Institute Trustee Judy Hale present the proceeds of “Saving by Shaving” to the money that has been invested Dana-Farber President and CEO Edward J. Benz Jr., MD, cheered on by (from Jane and Brian Crowley support investigations by F. Stephen Hodi, into the research of melanoma left) Quincy Mayor Thomas Koch, Governor Charlie Baker, and his wife, Lauren. MD (above), into melanoma to help families affected by the disease. has helped many people with the disease,” said Brian. ■

The Paper Store is a valuable partner in the fight against cancer

past fiscal year, contributing to a WHEN ELIGIBLE MASSACHUSETTS cumulative total of nearly RESIDENTS GIVE $25 OR MORE TO $1.2 million raised for Dana-Farber. In addition, employees of The Paper DANA-FARBER AND THE JIMMY FUND, Store have teamed up to Rally for the ARBELLA GIVES THEM: “We hope the money Jimmy Fund each year since 2011, we raise will help raising more than $16,500 to date ease the burden of through the popular, Red Sox-themed fundraiser. cancer on families As one of the largest family- everywhere.” owned and operated specialty gift store chains in New England, The 8% OFF — ROBERT ANDERSON, founder, Paper Store feels a special connection The Paper Store to New England’s favorite charity, THEIR ARBELLA AUTO the Jimmy Fund, and a special INSURANCE POLICY appreciation for Dana-Farber’s New England specialty gift retailer compassionate patient care. “The The Paper Store has partnered with Paper Store is a place where everyone Dana-Farber and the Jimmy Fund is treated like family,” said Founder since 2010, raising vital funds to Robert Anderson, “and it’s clear that conquer cancer. During the holiday patients at Dana-Farber feel they are CONTACT YOUR LOCAL MA AUTO INSURANCE season, The Paper Store offers being cared for like family.” AGENT FOR MORE DETAILS items from Dana-Farber’s Holiday The Paper Store takes pride in its Collection of cards, ornaments, and growth from a single stationery shop gifts, and during the summer, invites in 1964 to a major retailer offering guests to Strike Out Cancer by giving the highest quality products and to the Jimmy Fund. In exchange for a service. “We are pleased to partner gift during checkout, guests receive a with a world-class institution like baseball pin-up they can personalize Dana-Farber,” Anderson said. “We and display. Through these programs hope the money we raise will help The Paper Store raised more than ease the burden of cancer on families $330,000 in its 55 stores during the everywhere.” ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 9 ASH expands early-career Tina’s Wish drives early detection funding with nearly $600,000 research in ovarian cancer in grants to Dana-Farber including Dana-Farber and four of the nation’s top medical institutions— dedicated an additional $1 million that brings together world-class to its Scholar Awards fund this physician-scientists to develop year in response to the challenging innovative prevention and diagnostic federal funding climate. “The work Tina Brozman was an extraordinary strategies for ovarian cancer. Through of these investigators is what’s woman. The youngest judge ever initiatives like these, the foundation leading the innovations we’re seeing appointed to the U.S. Bankruptcy continues to further its mission, in hematology right now.” Court for the Southern District of “Know Early. Know Hope.®” Knoechel continues studies into New York, she was widely respected “We’ve seen incredible hope from the mechanisms of resistance in as a brilliant attorney, a dedicated the passion that investigators are acute T-cell lymphoblastic leukemia. mentor, and—most importantly— bringing to their research and from The mission of the American Lohr works to develop a new beloved wife and mother to three the progress that they’ve made thus Society of Hematology (ASH) is to technique to genetically profile children. After her passing from far,” said Amy Kyle, Institute Trustee conquer blood diseases worldwide. multiple myeloma with reduced ovarian cancer, The Honorable Tina and president of the foundation. To help realize this mission, ASH patient discomfort. Whangbo hopes Brozman Foundation, also known as “We still have a long way to go, fosters a climate of research and to establish a potential treatment Tina’s Wish, was established in her but we’re moving closer to our goal innovation in hematology through strategy for chronic graft versus host memory to propel groundbreaking of discovering an economical and highly competitive grant programs, disease in children. And Landau research for the early detection and effective early detection test for including the ASH Scholar Awards. researches the cellular evolution prevention of this disease. ovarian cancer.” ■ This year, ASH awarded Dana-Farber of relapsed chronic lymphocytic At Dana-Farber Cancer Institute, physician-scientists a total of $592,000 leukemia (CLL) and the genetic the foundation is currently for their studies in critical areas of he- predictors for progression-free supporting two projects: Jarrod matology research. Dana-Farber junior survival. Marto, PhD, director of the Blais “We still have a long faculty members Birgit Knoechel, MD, “The ASH Scholar Awards are Proteomics Center at Dana-Farber, way to go, but we’re PhD, Jens Lohr, MD, PhD, and Jennifer transformative for early career received a grant of $100,000 to fuel moving closer to our Whangbo, MD, PhD, and fellow Dan investigators,” said Robert Soiffer, studies focused on identifying the goal of discovering Landau, MD, PhD, joined a prestigious MD, chief of the Division of distinct proteins that ovarian cancer group of 31 ASH Scholars—the largest Hematologic Malignancies. “For cells secrete into the bloodstream, an economical cohort of Scholar Award recipients in some of these investigators, it may and Dipanjan Chowdhury, PhD, and effective early ASH history. be the first support they receive, and received a grant of $200,000 to look detection test for “These awards give talented young it gives them the chance to pursue for the specific genetic alterations in physician-scientists the opportunity research that they otherwise might microRNAs that regulate the cancer- ovarian cancer.” to dedicate time and attention to not be able to focus on.” preventing BRCA genes. Alterations ­ — AMY KYLE, Institute Trustee their research, instead of the pursuit “To support research is to in microRNAs may emerge as early and president of The Honorable of incremental funding for their support the future of this field and markers for detecting ovarian cancer. Tina Brozman Foundation labs,” said Patricia Frustace, director treatments for these diseases,” said Tina’s Wish also is funding a of development for ASH, which Frustace. ■ collaborative research consortium—

Jimmy Fund Big Ideas Contest

The Jimmy Fund Big Ideas Contest, a biennial contest that solicits innovative fundraising ideas from the general public, received 209 submissions from 19 states this spring. Five finalists were selected to present their ideas to a panel of judges and a live audience at a June 10 event emceed by WCVB-TV/Channel 5’s Phil Lipof. The judges crowned the Surprenant family the grand prize winners with “Jimmy Fund Jokers: Laughter is the Best Medicine,” a campaign utilizing social media to share jokes and raise money.

At left, Michael, Joy, and Maxwell Surprenant display their winners’ certificate surrounded by judges who mentored and offered expertise to each finalist (from left): Institute Trustee Daniel Kraft, president, the Kraft Group-International; Pam Hamlin, global president, managing partner, Arnold Worldwide; Institute Trustee Larry Lucchino, president/CEO emeritus, Boston Red Sox; John Donohue, chairman, president & CEO, Arbella Insurance Group; Bill Fine, president & general manager, WCVB- TV/Channel 5; and John Maguire, CEO, Friendly’s Ice Cream. (Not pictured, Institute Trustee Laura Sen, president & CEO, BJ’s Wholesale Club, Inc.)

Contributing stock or securities is an easy and efficient way to invest in Dana-Farber and the Jimmy Fund’s mission to create a world without cancer—with additional benefits for you! Give Stock To learn more about the power of giving stock and securities, contact Caitlin Fink at [email protected] or (617) 582-7537. to Give Hope To arrange a stock transfer, contact Nina Khosrowsalafi at [email protected] or (617) 632-5501. dana-farber.org/stock

Always consult with your tax advisor for specific tax information when giving securities, as certain limitations to deductions may apply.

10 Impact | FALL 2015 Celebrate the season of giving at JimmyFund.org/holiday

Strong team effort raises $597,000 in the 2015 Rally for the Jimmy Fund

t takes a team to defeat cancer, and nowhere care since 2006. This year, 497 companies and Adjunct Assistant Professor Troy Boutelle challenged is that more evident than with Rally for the schools throughout New England joined together to his “Effective Sales” class to apply what they learned I Jimmy Fund presented by Next Step Living®. raise more than $597,000. State Street Corporation by fundraising for Rally for the Jimmy Fund as their Participants contributing $5 or more enjoyed the finished first among companies for the sixth semester project. The students teamed up to raise opportunity to wear their Red Sox gear at school consecutive year with $42,000 raised, and Bentley thousands of dollars through social media, heartfelt or the office on April 13 for Red Sox Opening Day University led the schools by raising $22,000. video appeals, sales at local businesses, and other at Fenway Park. Thanks to the collective efforts While every team’s hard work was truly creative tactics. of countless supporters, these small gifts have appreciated, Bentley stole the show this year Boutelle noted that the students were happy to translated into huge impact over the years, bringing by topping their category in their first year of give their all to such a good cause, saying, “Rally in more than $4.6 million for cancer research and participation. It began in the classroom, where for the Jimmy Fund was a rewarding experience for all of us, and we took pride in what we were able to accomplish together.” This achievement did not go unnoticed by other top Rally teams—team leaders from companies like State Street and John Hancock personally contacted Jimmy Fund staff to praise the Bentley effort. Proceeds from Rally provide unrestricted, flexible funding that may be directed where most needed to advance Dana-Farber’s mission. Priority areas include Members of Bentley University’s “Effective Sales” class met with Red Sox player and Jimmy Fund Co-Captain discovery science, patient care, community outreach, Brock Holt (center) at Fenway Park as their prize for being the top school fundraising team in Rally for the Jimmy Fund. and capital improvements, among others. ■

American Heart Association grant paves way for cardiovascular disease prevention strategies

arc Vidal, PhD, director of transcriptomic, and epigenetic analysis called the interactome. By interacting Dana-Farber’s Center for of CVD subtypes. Transcriptomics is with other proteins and molecules, M Cancer Systems Biology, has the system of gene readouts in a cell, proteins enable cells to survive, received a two-year, $500,000 grant while epigenetics is like a traffic signal reproduce, and fulfill their role from the American Heart Association for the molecular machinery that within the body. Genetic mutations (AHA) as part of a groundbreaking turns genes on and off. can introduce errors in the makeup new program to develop personalized “Because genomics, epigenomics, of specific proteins, potentially treatment and prevention strategies and transcriptomics are functionally interfering with the proteins’ for cardiovascular disease (CVD) and related,” said Vidal, “integrated interactions and leading to disease. stroke. analysis will reduce longstanding With the AHA grant, Vidal Called the Cardiovascular Genome- gaps in our knowledge of CVD risk and his team will take a systems Phenome Study, the program and identify epigenetic marks that biology approach to CVD, which enables researchers for the first time regulate gene expression.” will provide a deeper understanding Marc Vidal, PhD, is analyzing protein interactions as part of an American to simultaneously access massive In turn, that knowledge may lead of disease mechanisms, identify Heart Association study. volumes of deeper-level data from to strategies for early prevention biomarkers shared among multiple multiple studies, including the and novel therapies for CVD. Vidal’s disease subtypes, and decipher the Framingham Heart Study and the research focuses on constructing genetic and epigenetic architecture develop and implement personalized Jackson Heart Study. Vidal’s project a map of interactions among the underlying the disease. Based on their medicine strategies in the treatment focuses on the integrated genomic, various proteins in human cells— findings, Vidal and his team will then and prevention of CVD. ■

Hyundai Hope On Wheels fuels progress in pediatric cancer research

therapies for children with chronic myelogenous demonstrates great promise in detecting Ewing leukemia (CML). sarcoma,” said O’Neill. “This grant will allow us to “Despite many recent advances in the manage- hone our technique, with the goal of improving ment of CML, challenges remain, especially for patient diagnosis and treatment.” younger patients,” said Orkin. “This award is em- In addition to Hope On Wheels, Hyundai powering us to conduct preclinical studies to identi- supports Dana-Farber through sponsorship, local fy treatment strategies directed at curing CML.” dealer fundraising, and programs including the Hope On Wheels awarded a $250,000 Scholar Boston Marathon® Jimmy Fund Walk presented When New England-area Hyundai dealers began Hope Grant to Kimberly Stegmaier, MD, co-director by Hyundai. to fund pediatric cancer research in 1998, they of the Pediatric Hematologic Malignancy Program, to “Hyundai Hope On Wheels is honored to work chose to direct their support to Dana-Farber Cancer validate new inhibitors against pediatric solid tumors. with Dana-Farber and the Jimmy Fund to uncover Institute and the Jimmy Fund. Now a national “Thanks to generous support from Hyundai, we new treatments for young patients with cancer,” effort with support from Hyundai Motor America are taking the steps needed to leverage our recent said Hyundai Hope On Wheels Board Member and dealers nationwide, Hope On Wheels continues discoveries and test a new class of anti-cancer drugs and President of Lester Glenn Auto Group Adam to support studies at Dana-Farber, including three against neuroblastoma and other solid tumors,” Kraushaar. “We are tremendously proud of the new grants totaling $650,000. said Stegmaier. projects we have supported at Dana-Farber for more A $250,000 Scholar Hope Grant was awarded to Allison O’Neill, MD, received a $150,000 than 15 years, and we look forward to continuing Stuart Orkin, MD, chair of Pediatric Oncology and Hyundai Scholar Young Investigator Award to to partner with this world-class organization to the David G. Nathan, MD, Professor of Pediatric enhance the diagnosis of Ewing sarcoma. propel discoveries.” ■ Hematology/Oncology, to identify more impactful “We designed novel imaging technology that

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 11 To include Dana-Farber in your estate plans, contact us at 617-632-3756

American Institute for Cancer Swimmers support survivorship Research grant furthers study Compassionate swimmers of all ages and abilities plunged into the pool, harbor, and ocean for three Swim Across America (SAA) events in of the effect of exercise on Massachusetts this year. In April, nine teams participated in a two-hour relay at Harvard University’s Blodgett Pool. On July 10, Olympians Carlton Bruner, breast cancer Kristy Kowal, Heather Petri, Erik Vendt, Eric Wunderlich, and SAA President and CEO Janel Jorgensen McArdle, joined the swimmers for a 22-mile, relay- Cancer Research is delighted to style course in Boston Harbor. The Olympians returned the next day for an support Dr. Ligibel’s work,” said open water swim at Nantasket Beach in Hull, Mass. Susan Higginbotham, PhD, RD, the SAA is a national organization that raises money and awareness for cancer institute’s vice president of research. programs through dozens of swim-related events each year. In 2015, $150,000 “We are confident her investigation was raised for the David B. Perini, Jr. Quality of Life Clinic at Dana-Farber, and will shed much-needed light on supported fellow Eric Zhou, PhD, for a fourth year as he continues to conduct In 1982, the American Institute for an area that cries out for it—the valuable research into late and long-term effects of cancer treatment, such as Cancer Research charted a unique mechanisms by which physical insomnia, in adolescent and young adult survivors. course toward disease prevention activity protects against breast cancer by funding studies on nutrition, progression.” physical activity, and cancer. These Ligibel is conducting this work as trailblazing investigations showcase part of Dana-Farber’s Preoperative the critical importance of researching Health and Body study, which cancer through the lens of lifestyle delves into the underlying biology choices, and demonstrate how of the cellular mechanisms that link evidence-based recommendations exercise with improved breast cancer for healthy living can impact patient outcomes. health. Expanding their support for “I’m very grateful for this support this area, the American Institute for from the American Institute for Cancer Research awarded a grant of Cancer Research,” said Ligibel. “This $165,000 to Jennifer Ligibel, MD, grant will enable us to explore more senior physician in the Susan F. thoroughly the biological impact of Smith Center for Women’s Cancers exercise on breast cancer, and guide and director of the Leonard P. Zakim our ongoing efforts to bring the Center for Integrative Therapies at benefits of exercise to breast cancer Dana-Farber. patients.” ■ “The American Institute for

Papa Gino’s and D’Angelo Uniting Against Lung Cancer surpass $1 million cumulative powers promising SCLC research milestone

his summer, Papa Gino’s and than $193,000 was raised for Dana- D’Angelo Grilled Sandwiches Farber’s lifesaving mission in 2015, T once again proved that bringing the cumulative total to $1 customers can save lives while saving million. money. Continuing a tradition The campaign kicked off on July started in 2009, employees at both 1 with a rousing celebration at the restaurants sold $1 coupon sheets Yawkey Center for Cancer Care. espite incredible therapy ing for innovative ideas that research- July 6 through Aug. 9, with proceeds District managers from participating breakthroughs for many ers like Dr. Christensen Ross may going to support the Jimmy Fund. restaurants toured the expanded D types of lung cancer, there have, and we are proud to support Through dedicated efforts and the Jimmy Fund Clinic and heard an has not been significant progress in high-quality research being conduct- generosity of their customers, more inspiring talk from Lisa Przybylski, the development of treatments for ed at institutions like Dana-Farber.” mother of the campaign’s featured small cell lung cancer (SCLC), the Christensen Ross’ study examines patient partner, Wynter. According most aggressive type of lung cancer, the potential of using the molecule to Lisa, Wynter, a bone marrow since chemotherapy was introduced THZI to treat SCLC. Initial research transplant survivor who wants to be in the 1970s. shows SCLC cells are highly sensitive a singer when she grows up, remains Dana-Farber’s Camilla to THZI, which inhibits transcription, thankful to Dana-Farber for the Christensen Ross, PhD, aims the first step of genes creating lifesaving treatment she received. to change that with a generous products. “We are truly grateful to everyone $100,000 grant from Uniting “By focusing on promising involved in this coupon campaign Against Lung Cancer, now known transcription-targeting drugs with because they help make stories like as the Lung Cancer Research the help of this funding, we may be Wynter’s possible,” Lisa said. “We Foundation (LCRF). able to uncover more about SCLC and were thrilled to be able to give back “We believe that our founda- further direct treatment decisions,” in this way.” tion fills a gap in funding for pilot said Christensen Ross. For their part, Papa Gino’s and projects that may lead to improved “This is a pivotal time in lung Wynter Przybylski, the Jimmy Fund D’Angelo staff were happy to help. therapies, diagnostic technologies, cancer research,” said Baranski. “A Clinic patient featured during this Mark DeBlois, chairman and CEO at cancer screenings, and prevention number of exciting developments year’s Papa Gino’s and D’Angelo Grilled Sandwiches campaign, received Papa Gino’s, said, “It is a privilege to that will reach patients and improve have been made, and researchers lifesaving treatment made possible by support the Jimmy Fund because we lives,” said Jan Baranski, PhD, direc- are working to translate them into funds raised through the Jimmy Fund know every dollar raised will make tor of scientific programs for LCRF. clinically relevant therapies that will and its corporate partners. an impact at Dana-Farber.” ■ “We are providing seed-stage fund- impact patients on a larger scale.” ■

12 Impact | FALL 2015 Stop & Shop celebrates 25 years and $58 million in support of pediatric­ cancer research

opportunities for clinical trials for cancers,” said Dana-Farber’s Andrew next decade. As we learn more about pediatric patients. Place, MD, PhD. “The technology that tailoring treatments, the outcome for “Thanks to the incredible support has been developed to help identify pediatric patients will be improved from Stop & Shop, we have been new targets in genes is revolutionary significantly. This progress wouldn’t able to investigate new drugs and and will lead to tremendous progress be possible without the generosity of ince 1991, the Stop & Shop less-toxic treatments for pediatric in pediatric cancer research in the Stop & Shop.” Supermarket Company has To celebrate the 25th anniversary S partnered with the Jimmy of the Triple Winner Program, Stop Fund to offer the Triple Winner & Shop held a kick-off event for Game, which gives customers the franchisees at Fenway Park in March. opportunity to support Dana-Farber The speaking program included Lisa by contributing $1 to the Jimmy Fund Scherber, director of patient and and receiving a Triple Winner scratch family programs at the Jimmy Fund ticket. Triple Winner participants can Clinic, and former Jimmy Fund Clinic receive free store products, coupons, patient Matthew Courtney, who gift cards, or cash prizes. Promotional was featured on the Triple Winner material for the program features promotional material in 1991. “I am Over the past 25 years, Stop & Shop Supermarket Company has contributed more than Jimmy Fund Clinic patients from $58 million to pediatric cancer research at Dana-Farber Cancer Institute. a good example of how your support various New England states. can help children with cancer,” said This year, Stop & Shop and its Courtney. “There is hope. Stop & Our Family Foundation once again Shop and the Jimmy Fund Clinic are presented Dana-Farber and the “We are incredibly proud of our commitment the reason why I am still here.” Jimmy Fund with a check for $2.5 to helping eradicate children’s cancer, and are “We are incredibly proud of our million, bringing its total cumulative grateful for the unwavering support we have commitment to helping eradicate giving to more than $58 million. children’s cancer, and are grateful As one of Dana-Farber’s largest received from our customers, associates, and for the unwavering support we corporate partners, Stop & Shop’s vendors.” have received from our customers, funding makes a significant impact in associates, and vendors,” said Mark advancing groundbreaking pediatric — MARK MCGOWAN, president of Stop & Shop New England Division McGowan, president of Stop & Shop cancer research, empowering Dana- New England Division. ■ Farber researchers to discover new

Theatre Collections turns the Giacalone Fund advances spotlight on cancer ovarian cancer clinical trials

he Jimmy Fund/Variety joined the effort for the first time hile Joan “Stevie” director of gynecologic oncology at Children’s Charity Theatre this year, inviting patrons of this Giacalone was being Dana-Farber’s Susan F. Smith Center T Collections, the Jimmy Fund’s scintillating live performance to W treated for ovarian cancer for Women’s Cancers, the fund will longest-running fundraiser, is still make contributions as they left the at Dana-Farber, she wanted to help support both laboratory-based going strong after 66 years. From theatre. The Regal Foundation once help find a cure research and clinical June 12 to July 30, thousands of again made a generous $125,000 for the disease that trials of novel drug moviegoers at National Amusements contribution to the program, eventually took her combinations that theatres in Massachusetts, Rhode bringing the total raised through the life by increasing may be effective at Island, Connecticut, New York, New 2015 Theatre Collections to nearly the number of overcoming this Jersey, and Ohio gave generously $413,000. clinical trials obstacle. after viewing a trailer depicting Theatre Collections is a tradition available to women. “The Giacalone Dana-Farber and the Jimmy Fund’s nearly as old as the Jimmy Fund To honor that desire Fund will help us compelling story, when dedicated itself. In 1948, leaders of the Variety and inspire others move laboratory volunteers passed canisters down the Club of New England were drawn to support ovarian findings into clinical aisles. Blue Man Group in Boston to the groundbreaking work being cancer research, trials to test the done by Sidney Farber, MD, to her sister and effectiveness of treat childhood leukemias. The father, Patricia and these combination organization’s support led to the Joseph Giacalone, therapies, which we famed 1948 radio broadcast that established the believe will be far made a pediatric patient dubbed Joan S. Giacalone superior to single- “Jimmy” a household name. Ovarian Cancer drug treatments for Theatre Collections was launched Research Fund with ovarian cancer,” said the following year, with the help a $100,000 gift to Matulonis. of Hollywood stars such as Spencer Dana-Farber. The Joan S. Giacalone Stevie’s passion was Ovarian Cancer Research Tracy, Bing Crosby, and Debbie While some Fund was established by to make a difference Reynolds, who made the now- newer drugs have Patricia Giacalone to honor for other women with her sister, Joan “Stevie” familiar Jimmy Fund movie theatre proven effective at Giacalone, above. ovarian cancer, said trailers. Since that time, Theatre targeting genetic her sister. “This is a re- Collections has raised nearly abnormalities ally tragic disease and $29 million for Dana-Farber and that drive ovarian cancer, tumors is underfunded in terms of research,” the Jimmy Fund. ■ often develop resistance to these said Giacalone. “Funding ovarian can- single agents. Under the direction cer research is Stevie’s way of helping of Ursula Matulonis, MD, medical other women live a full life.” ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 13 HomeGoods celebrates banner year for fundraising

Mass., loves playing, princesses, and Dana-Farber and the Jimmy Fund These funds enable Institute practicing art when not in treatment. in its mission to help families fight leaders to be nimble and apply When she grows up, Kate would like cancer.” monies rapidly when promising to be a chef or a ballerina. Her As a dedicated supporter of new research opportunities arise; For 15 years, through initiatives in colorful artwork adorned thousands Dana-Farber Cancer Institute and enhance the programs and initiatives their retail locations, HomeGoods of bags that were sold at stores. the Jimmy Fund, HomeGoods has that serve the spiritual, emotional, has made an important impact on “We are grateful to our customers raised millions of dollars that support and psychosocial needs of patients Dana-Farber’s fight against cancer. and associates who generously research and patient care for children and their families; attract, develop, Their dedicated staff and generous support Dana-Farber Cancer Institute and adults faced with cancer. This and retain the best and the brightest customers raised a record-breaking and the Jimmy Fund,” said Robyn year, in recognition of HomeGoods’ minds in research and care; and $1.4 million in 2015 through the Arvedon, HomeGoods spokesperson. ongoing commitment, Dana-Farber bolster underfunded services, annual “HomeGoods Helps Families “Each year, we are amazed by their named the HomeGoods Infusion Area including social work, community Fight Cancer” promotional campaign. passion and commitment to support in the Jimmy Fund Clinic. outreach, and cancer prevention. ■ From June 4 to 28, more than 335 stores across the country displayed bright and distinctive signage featuring Jimmy Fund Clinic patient artwork, and customers were invited “We are grateful to to give at the register. our customers and Every summer, the national off- price home fashions retailer also offers associates who customers the opportunity to purchase generously support a reusable shopping bag. For every Dana-Farber Cancer 99-cent bag sold, 50 cents is given to Dana-Farber and the Jimmy Fund. Institute and the This year’s bag featured artwork by Jimmy Fund.” 7-year-old Jimmy Fund Clinic patient Kate Morris from Watertown, Mass. —ROBYN ARVEDON, HomeGoods spokesperson Last January, Kate was diagnosed with acute lymphoblastic leukemia 7-year-old Jimmy Fund Clinic patient Kate Morris with her custom-designed (ALL). Kate, a first-grader at the Brim- HomeGoods bag mer and May School in Chestnut Hill,

Stemline Therapeutics supports discovery in rare leukemia

Lane, MD, PhD, to fuel his research into the biology of BPDCN. “I’m interested in understanding how the disease is initiated, progresses, and develops drug resistance,” said Lane. “The generous support of “We hope Dr. Lane’s Stemline will allow me to determine research will shed the prime biological targets for therapy light on how and predict which types of therapies may be most effective for treating therapeutics act patients. This work may also inform to eliminate or better treatments for other types of thwart progression AML that have a poor prognosis.” of disease.” One of these treatments might be Stemline’s therapeutic, SL-401, which

— CHRISTOPHER BROOKS, PHD Stemline is currently studying in VP of research and development, BPDCN and AML clinical trials. The Knocking out cancer Stemline Therapeutics, Inc. company is excited to support Lane’s research into the disease. “We hope When Julie Anne Kelly and fellow Bostonian Andrew Myerson (above) Dr. Lane’s research will shed light on met in 2008, they were both training for the New York City Golden Gloves Blastic plasmacytoid dendritic cell how therapeutics like SL-401 act to boxing tournament. Kelly, a cancer survivor, was a defending champion, and neoplasm (BPDCN) is a rare, aggressive eliminate or thwart the progression Myerson, an amateur, had lost a close friend to the disease. The pair decided to fight for cures in and out of the ring by founding Haymakers for Hope, a form of acute myeloid leukemia (AML) of disease, improving outcomes for charity that trains amateur boxers and organizes tournaments to raise money with no established therapy. With the patients with BPDCN,” said Stemline’s for cancer research. support of Stemline Therapeutics, Inc., Vice President of Research and Devel- Dana-Farber may be one step closer to opment Christopher Brooks, PhD. Two annual Boston-based events benefit Dana-Farber and the Jimmy Fund: finding a treatment. “With this support, our work is the all-female Belles of the Brawl transformed Royale Boston into a boxing ring on Oct. 2, 2014, while the 5th annual Rock N’ Rumble, this past May at Recently, Stemline Therapeutics, already generating interesting new the House of Blues Boston, featured 30 amateur boxers, including cancer Inc., a biopharmaceutical company information. We look forward to survivors and Dana-Farber researcher John Quakenbush, PhD. Together, that develops cancer therapeutics, continuing progress in understanding these events raised nearly $240,000 for Dana-Farber, contributing to nearly including those for so-called BPDCN, and to giving patients with $936,000 that Haymakers for Hope has raised to date. “orphan” diseases, made a gift of this disease a fighting chance,” $100,000 to Dana-Farber’s Andrew said Lane. ■

14 Impact | FALL 2015 Follow us at Facebook.com/TheJimmyFund and on Twitter @TheJimmyFund

Executive Council raises nearly $500,000 for women’s cancers

ach year, the Executive Council efforts to overcome drug resistance in discussion on Dana-Farber’s efforts to director of the Breast Oncology of the Susan F. Smith Center breast cancer. provide more effective treatments to Program, and Thompson Chair in E for Women’s Cancers hosts two Additionally, the Executive patients with ovarian cancer. Breast Cancer Research at Dana-Farber. events to educate guests on the latest Council raised more than $250,000 “For more than a decade, the “Their enthusiasm for our work advances in women’s cancers research last November at their sixth annual Executive Council has been a driving and their dedication to the Susan F. and clinical care, and to raise vital Beyond Boston Luncheon at the force behind our women’s cancers Smith Center has inspired our team funding for the Susan F. Smith Center Wellesley Country Club in Wellesley, research,” said Eric Winer, MD, chief to challenge themselves to find new for Women’s Cancers at Dana-Farber. Mass., which featured a panel of the Division of Women’s Cancers, ways of treating these diseases.” ■ “The Executive Council works tirelessly to advocate for the work of Dana-Farber physician-scientists,” said Susan F. Smith, honorary chair of the Executive Council. “Together, they have raised more than $10.6 million for cutting-edge breast and ovarian cancer research and care.” On Thursday, April 16, 2015, more than 200 guests attended the 12th annual Executive Council Breakfast, which raised close to $250,000 at the Co-Chairs of the Susan F. Smith Center Executive Council Beyond Boston Luncheon (left photo, from left): Carie Capossela, Pamela First Martin, and Meredith Beaton-Starr. Co-Chairs of the Susan F. Smith Center Executive Council Breakfast (right photo, from left): Barbara Mandarin Oriental, Boston, where Marx, Institute Trustee Deborah First, and Kathleen Whelan. attendees learned about Dana-Farber’s

Ribbon-cuttings commemorate generosity

aming space with a gift to Dana-Farber Cancer Institute and the Jimmy Fund is a N wonderful way to leave a lasting mark of your support for our lifesaving mission. Ribbon- cuttings were recently held to celebrate donors who named space in the Yawkey Center for Cancer Care and the Charles A. Dana Building with their In honor of their parents, Jean and Ralph Rudnick, generous gifts. ■ Constance Rudnick Grayson (center) and Rob Rudnick (right) named a consultation room in the With his gift to Dana-Farber’s Capital Projects mammography suite in the Charles A. Dana Building Campaign, Dr. Robert Sperber named a nourishment with their gift to the Capital Projects Campaign. Dana- area in the Yawkey Center for Cancer Care, in tribute Farber Clinical Director of Mammography Jack Meyer, to his wife, Edith. MD, joined them for the ribbon-cutting.

Impact | FALL 2015 | Volume 18 Issue 3

This issue covers gifts received and finalized through President and Chief Executive Officer Senior Vice President, Institute Operations Chief of Imaging May 2015, and events through August 2015. Edward J. Benz Jr., MD Maria Papola Megdal, MHA Annick D. Van den Abbeele, MD Executive Vice President and Chief Operating Officer Senior Vice President, Research Chief Clinical Strategy Officer Impact is a newsletter of Dana-Farber Cancer Institute published Dorothy E. Puhy, MBA Drew Memmott, MA, MPhil Eric P. Winer, MD by the Division of Development and the Jimmy Fund. Senior Vice President, General Counsel, Senior Vice President, Experimental Medicine For questions, or to be removed from our mailing list, and Chief Governance Officer Lee M. Nadler, MD Associate Vice President, Development Marketing Jan Lawlor please contact: Richard S. Boskey, Esq. Chair, Pediatric Oncology Chief Medical Officer Stuart H. Orkin, MD Impact Editor Dana-Farber Cancer Institute Lori Dougherty Craig A. Bunnell, MD, MPH, MBA Senior Vice President, Division of Development & the Jimmy Fund Senior Vice President, Experimental Therapeutics Development and the Jimmy Fund Art Director 10 Brookline Place West, 6th Floor George D. Demetri, MD Susan S. Paresky, MBA Sharon Veino Brookline, MA 02445-7226 617-632-3019 or 800-52-JIMMY Chief Medical Officer, Pediatric Oncology Senior Vice President, Patient Care Services Production Coordinators or visit jimmyfund.org/opt-out Lisa R. Diller, MD and Chief Nursing Officer Ryan Agate, Benjamin Gould, Jessamyn Martin Chair, Medical Oncology Patricia Reid Ponte, RN, DNSc, FAAN, NEA-BC Contributors Dana-Farber Cancer Institute provides expert, compassionate James D. Griffin, MD Chief Scientific Officer Colleen Akins, Jane Anderson, Jennifer Skala Bodio, Amanda care to children and adults and is home to groundbreaking Citrone, Erika Clapp, Dan D’Onofrio, Scott Edwards, Erica Chair, Radiation Oncology Barrett J. Rollins, MD, PhD cancer discoveries. Since its founding in 1948, the Jimmy Fund Equi, David Ferreira, Brittany Flaherty, Elizabeth Furilla, Kelsie Daphne Haas-Kogan, MD Chief of Staff Emeritus has raised millions of dollars through thousands of community Guerriero, Katherine McIsaac, Erin McVeigh, Kevin Miller, Stephen E. Sallan, MD efforts to advance Dana-Farber’s lifesaving mission. Chair, Executive Committee for Research Maria O’Meara, Erin Podolak, Maureen Quinn, Michael Quinn, William C. Hahn, MD, PhD Senior Vice President, Communications Arielle Rollins, Laura Shannon, Bailey Snyder, Heidi Ziegler-Voll, Senior Vice President, Human Resources Steven R. Singer, MPA Monica Zurlinden Deborah Hicks, MA Chair, Executive Committee for Clinical Programs Photography Chief Quality Officer Robert J. Soiffer, MD 13 Photography, Michael Blanchard, John Deputy, Erica Equi, Joseph O. Jacobson, MD, MSc Chief of Staff FayFoto Boston, Caitlin Galluzzo, Pat Giacolone, Margaret Chief Clinical Research Officer Richard M. Stone, MD Harrison, Matthew Macomber, Jessamyn Martin, Katherine Bruce E. Johnson, MD Chief Surgical Officer McGuirk, Sam Ogden, James O’Mara, Pan-Mass Challenge, Person + Killian Photography, LLC, SLY Photography, Senior Vice President, Business Development, Scott J. Swanson, MD Snowbound, Bryce Vickmark, Aaron Washington, Mao Youdong Clinical Planning, and Community Site Operations Chair, Psychosocial Oncology Elizabeth A. Liebow, MS and Palliative Care James A. Tulsky, MD

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission FALL 2015 | Impact 15 Holliston, MA Holliston, MA Permit NO . 20 Permit NO . 20

FALL 2015 Volume 18 | Issue 3

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Dana-Farber Cancer Institute Impact Division of Development & The Jimmy Fund dana-farber.org and jimmyfund.org THANKING THOSE WHO MAKE A DIFFERENCE 10 Brookline Place West, 6th Floor Brookline, MA 02445-7226

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Boston Bruins players Jimmy Hayes (left) and Torey Krug paid a visit to Dana-Farber’s Jimmy Fund Clinic in August to meet young patients like Samantha Caldwell and her mom, Anne Caldwell.

CALENDAR OF EVENTS For more information on all Jimmy Fund and Dana-Farber events and programs, go to jimmyfund.org or dana-farber.org

NOVEMBER NOW ­– JANUARY FEBRUARY Dana-Farber & the Jimmy Fund’s NOW ­– DECEMBER 4 Holiday Collection FEBRUARY 18 Presented by Amica Insurance Cheer for Dana-FarberSM Palm Beach Pre-Celebration Dinner Presented by Walmart New and exclusive cards and gifts, proudly Join us for an intimate dinner with the Institute’s pioneering made in New England. physician-scientists at the Palm Beach home of Lawrence Moens, Celebrate the season with who is hosting the event with Event Chairs Phyllis Krock, an Institute a tradition that conquers Trustee, and Tom Quick. Contact Karen Martins at 561-833-2080 or cancer. See the complete [email protected]. collection at dana- PRESENTED BY farberholiday.org. FEBRUARY 19 Cheerleading squads across New England are raising vital funds for Dana-Farber while competing for the opportunity to perform Palm Beach Breakfast with the Doctors prior to a New England Patriots home game. Support a team at JANUARY cheerfordanafarber.org or contact Nicole Allo at 617-632-5461 Discuss the latest breakthroughs with Dana-Farber physician-scientists or [email protected]. JANUARY 2 – 3 at the Palm Beach Country Club, hosted by Event Chairs Robert Belfer, an Institute Trustee, his wife, Renée, and Vicki and Arthur Loring. Contact The Resolution by PMC Karen Martins at 561-833-2080 or [email protected].

Kick off the new year with The Resolution by PMC, a new indoor NOW – DECEMBER 14 cycling event from the Pan-Mass Challenge to help Dana-Farber find FEBRUARY 20 Kick for Dana-Farber cures for all forms of cancer. Register to ride, volunteer, or make a gift at the-resolution.org. Palm Beach 25th Anniversary Discovery Celebration

Join us for the premier event of our Palm Beach season at the historic JANUARY 22 Mar-a-Lago Club, featuring a special performance by James Taylor. The event is chaired by Event Chairs Judie Chefs for Jimmy Schlager, an Institute Trustee, and her This exciting new program gives youth soccer teams the chance to husband, Larry, as well as Event Co- win an exclusive on-field Rally Tunnel experience at a New England Sample fare from Western New England’s finest chefs at Chez Josef in Chairs Peter Palandjian, an Institute Revolution home match, and clinics with Revolution players and Agawam, Mass., at this 26th annual event benefiting the Jimmy Fund. Trustee; Amy and Robert Schlager; coaches, while raising funds for Dana-Farber. Register or support a team For tickets or to learn more contact Kerry Sachs at 617-582-7916 or Eric Schlager, an Institute Trustee, and at kickfordanafarber.org or contact Casey Pereira at 617-632-3863 [email protected]. his wife, Beth; and Joan and Mark or [email protected]. Weinstein. Contact Karen Martins at 561-833-2080 or [email protected].