Satellite Events SFRR-E/SNFS Meeting 2015 September 1, 2015 University of , Stuttgart, Germany

Tuesday, 1 September 2015 Location: Euro-Forum, Katharinasaal (Kirchnerstr. 3, 70599 Stuttgart) 08:00 SFRR-E/SNFS Conference Registration Opens VITAMIN E SATELLITE SYMPOSIUM (Euro-Forum) 08:30 Welcome – Prof. Jan Frank 08:40 – 11:20 Novel aspects of vitamin E metabolism and activity (Euro-Forum) Chairs: Prof. Marc Birringer, University of Applied Sciences Fulda, Germany and Prof. Jan Frank, , Germany 08:40 – 08:50 Introduction – Prof. Marc Birringer 08:50 – 09:10 Novel activities of tocopheryl-phosphates – Prof. Angelo Azzi, Tufts, USA 09:10 – 09:30 Intracellular sorting and metabolism of vitamin E – Prof. Jan Frank, University of Hohenheim, Germany 09:30 – 09:50 The human endometabolome of vitamin E: investigation strategies and future perspectives – Prof. Marc Birringer, University of Applied Sciences Fulda, Germany 09:50 – 10:10 The path to functional characterization of long-chain tocopherol metabolites as immune-modulatory agents (molecular and functional characterization of long-chain metabolites) – Prof. Stefan Lorkowski, University of Jena, Germany 10:10 – 10:30 Coffee Break (Euro-Forum) 10:30 – 10:50 Present trends in lipidomics: the case of vitamin E – Prof. Gabriele Cruciani, , Italy 10:50 – 11:10 In vivo neuroprotection of vitamin E in a pharmacological model of epilepsy by glutamate excitotoxicity – Prof. Francesco Galli, University of Perugia, Italy 11:10 – 11:30 Vitamin E-vitamin K interactions – Prof. Maret Traber, Linus Pauling Institute, USA 11:30 – 12:30 Lunch break (Euro-Forum) 12:30 – 15:40 Vitamin E in Health and Disease (Euro-Forum) Chairs: Prof. Francesco Galli, University of Perugia, Italy and Prof. Stefan Lorkowski, University of Jena, Germany 12:30 – 12:40 Introduction – Prof. Francesco Galli 12:40 – 13:00 Vitamin E – status, essentiality and beyond – Prof. Manfred Eggersdorfer, DSM Nutritional Products, Switzerland 13:00 – 13:20 Vitamin E in Alzheimer’s Disease – Prof. Maurice Dysken, University of Minnesota, USA 13:20 – 13:40 Regulation of endoplasmic reticulum stress pathways by vitamin E in 13:30 – 16:00 Elsevier Workshop on ‘Writing for cholesterol-induced disorders – Prof. Nesrin Kartal Özer, Marmara Peer Review Journals’ (HS 4, University, Turkey Hohenheim Castle) – Anthony Newman, Elsevier 14:00 – 14:20 Immuno-modulatory effects of vitamin E in health and disease – Prof. Joan Cook-Mills, Northwestern University, USA 14:20 – 14:40 Vitamin E Pharmacokinetics and Bioavailability in Healthy Women – Dr. Mark Levine, National Institutes of Health, USA 14:40 – 15:00 Closing remarks (Euro-Forum) – Prof. Jan Frank 16:30 – 18:30 SFRRE Executive Meeting (Seminar Room 106, Euro-Forum) SFRR-E/SNFS Meeting Stuttgart 2015 Redox Biology Meets Nutrition September 2-4, 2015 University of Hohenheim, Stuttgart, Germany

SFRR-E/SNFS MEETING WEDNESDAY, 2 – FRIDAY, 4 SEPTEMBER 2015 Wednesday, 2 September 2015 Location: Euro-Forum, Katharinasaal (Kirchnerstr. 3, 70599 Stuttgart) 07:00 SFRR-E/SNFS Conference Registration Opens (Euro-Forum) 08:00 – 08:15 Welcome Address (Euro-Forum) Prof. Jan Frank, President of SNFS, Meeting Chairman, University of Hohenheim, Germany and Prof. Giovanni Mann, President of SFRR-E, King’s College London, United Kingdom 08:15 – 09:00 SFRR-Europe Annual Award Lecture (Euro-Forum) Chair: Prof. Kelvin Davies, University of Southern California, USA 08:15 – 09:00 Redox Biology and Metabolism in Brain Aging and Alzheimer's Disease – Prof. Enrique Cadenas, University of Southern California, USA 09:00 – 11:00 SFRR-E/SNFS Early Career Investigators Forum (Euro-Forum) Chairs: Dr. Barbara Rocha, , Portugal; Dr. Christina Schiborr, University of Hohenheim, Germany; and Dr. Salil Srivastava, King’s College, London, UK 09:00 – 09:15 Molecular mechanisms of mitochondrial protection against oxidative damage in hibernators - the anti-aging effects of heterothermy – Dr. Milica Vucetic, University of Belgrade, Serbia 09:15 – 09:30 HSP90 impairment through oxidative cleavage leads to oxidized proteins accumulation – Dr. José Pedro Castro, German Institute of Human Nutrition, Germany 09:30 – 09:45 Impact of the transcription factor NRF2 in the modulation of autophagy on TAU and β-amyloid pathology in a combined mouse model of Alzheimer's disease – Marta Pajares, Instituto de Investigaciones Biomedicas "Alberto Sols", 09:45 – 10:15 Coffee break (Euro-Forum) 10:15 – 10:30 Nitroglycerin-induced cardioprotection is endothelial nitric oxide synthase-dependent – Sofia-Iris Bibli, University of Athens, Greece 10:30 – 10:45 Investigation of the crosstalk between proteasome function and nucleotide excision repair mechanism during ageing – Maria Lefaki, National Hellenic Research Foundation, Greece 10:45 – 11:00 Sirtuins pathways and redox homeostasis: a pilot study on young and old monozygotic twin – Elisa Grazioli, University of Rome, Italy 11:00 – 12:00 Catherine Pasquier Memorial Award Lecture (shared) (Euro-Forum) Chairs: Prof. Josiane Cillard, , France and Prof. Nesrin Kartal Özer, Marmara University, Turkey 11:00– 11:30 Critical role of oxidative and nitrosative stress in pathophysiology: Inflammation, cell injury and cancer – Dr. Jordi Muntané, University Hospital “Virgen del Rocío”-“Virgen Macarena”, Institute of Biomedicine of Seville, Spain 11:30– 12:00 The adventure of detecting subtle signals (such as protein notrosothiols and superoxide) among cell traffic jams (from proteomics to hypoxia) – Dr. Antonio Martínez-Ruiz, Hospital Universitario de La Princesa, Madrid, Spain 12:00 - 13:00 Lunch break (Euro-Forum) SFFRE Council Meeting (Seminar Room 106, Euro-Forum) 13:00 – 15:00 Symposium 1 - Redox stress and aging of the skin (Euro-Forum) Chairs: Prof. Florian Gruber, Medical University of Vienna, Austria and Assoc. Prof. Johannes Grillari, University of Natural Resources Vienna, Austria 13:00 – 13:30 Redox-directed interventions targeting skin photodamage – Prof. Georg Wondrak, University of Arizona, USA 13:30 – 14:00 Nrf2 and epidermal barrier function – Dr. Matthias Schäfer, ETH Zürich, Zürich Switzerland 14:00 – 14:30 The use of an N/TERT epidermal model for skin sensitizer identification – Dr. Abdoel El Ghalbzouri, Leiden University Medical Center, Leiden, Netherlands 14:30 – 15:00 Oxidized phospholipids - markers and mediators in skin aging – Prof. Florian Gruber, Medical University of Vienna, Vienna, Austria 15:00 – 15:30 Coffee break (Aula, Castle)

Location: HS 1 (Hohenheim Castle) HS 4 (Hohenheim Castle) 15:30 – 17:30 Session 1: Redox biology of degenerative diseases Session 2: Dietary factors and health (HS 4) Chair: Dr. Alexa Kocher, University of Hohenheim, Germany Chair: Dr. Sascha Venturelli, Medical University Hospital Tübingen, Germany and Prof. Florian Fricke, University of Hohenheim, Germany 15:30 – 16:00 The role of paraoxonase 2 (PON2) in modulating the oxidant- Gut microbiome is rescued by dietary nitrate during dysbiosis: antioxidant balance of the peripheral blood mononuclear cells the impact on epithelial fence function and inflammatory in newly diagnosed type 2 diabetic patients – Dr. Daniela pathways during antibiotic therapy – Dr. Barbara Rocha, Lixandru, University of and Pharmacy Bucharest, University of Coimbra, Portugal Romania 16:00 – 16:30 Chemotherapy Resistance: The role of proteasomal Influence of curcumin on a pediatric hepatocellular carcinoma degradation and heat shock response – Dr. Betul Karademir, model in vitro and in vivo: significant reduction of alpha- Marmara University, Turkey fetoprotein and curcuminoid levels in mice – Dr. Verena Ellerkamp, University of Tübingen, Germany 16:30 – 17:00 Uncovering changes in the redox protein interactome of PTEN Investigations on the oral bioavailability of trans-resveratrol – Dr. Corinne Spickett, Aston University, United Kingdom and trans-ε-viniferin from native and micellar Vineatrol®30 grapevine-shoot extract in healthy volunteers – Laura Calvo Castro, University of Hohenheim, Germany 17:00 – 17:30 Natural antioxidants accelerate cachexia development in Xanthohumol derivatives as mild mitochondrial uncouplers colon cancer – Dr. Mohamad Assi, University of Rennes2, for treatment of metabolic syndrome – Prof. Jan Fred Stevens, France Linus Pauling Institute, Oregon State University, USA 17:30 – 19:30 Poster Presentations with Drinks (Aula, Castle) 19:30 – 21:00 Welcome Reception with Finger Food (Castle)

Thursday, 3 September 2015 07:30 SFRR-E/SNFS Conference Registration Opens (Euro-Forum) 08:15 – 10:15 Symposium 2 – Plant Redox Systems (Euro-Forum) Chairs: Prof. Frank van Breusegem, Ghent University, Ghent, Belgium and Prof. Christine Foyer, Leeds University, Leeds, UK 08:15 – 08:45 Genetic predisposition of grapevine to polyphenols accumulation - Prof. Massimo Delledonne, University of Verona, Italy 08:45 – 09:15 The evolution of vitamin C biosynthetic pathways in plants and algae - Prof. Nick Smirnoff, University of Exeter, UK 09:15 – 09:45 The importance of free radical scavenging to determining the shelf life of fruit - Prof. Cathie Martin, John Innes Centre - Norwich, UK 09:45 - 10:15 Glutathione transport into the nucleus - Prof. Christine Foyer, Leeds University, Leeds, UK 10:15 – 10:45 Coffee break (Aula, Castle) Location: HS 1 (Hohenheim Castle) HS 4 (Hohenheim Castle) 10:45 – 12:45 Session 3: Reactive oxygen species, metabolism and nutrition Session 4: Redox biology and aging (HS 1) Co-organised by COST action BM1203 (EU-ROS) and supported Chairs: Prof. Tilman Grune, German Institute of Human by European Cooperation in Science and Technology Nutrition, Germany Chairs: Prof. Fabio Di Lisa University of Padova, Italy and Prof. Lars-Oliver Klotz, University of Jena, Germany 10:45 – 11:15 Mitochondrial ROS formation in diabetic cardiomyopathy - Centenarians overexpress BCL-xL, which confers them a Prof. Fabio Di Lisa University of Padova, Italy protection against apoptosis, oxidative stress and immunosenescence – Dr. Consuelo Borras, University of , Spain 11:15 – 11:45 The pivotal role of proteasome enhancement in ageing, Oxidative Stress & the Decline of Adaptive Homeostasis in longevity and proteostasis across species - Dr. Niki Aging - Prof. Kelvin Davies, University of Southern California, Chondrogianni, National Hellenic Research Foundation, Greece USA 11:45 – 12:15 Resveratrol and Foxo1 modulate glucose metabolism - Prof. Laminin, a key component of tissue extracellular matrix, is a Thomas Kietzmann, , Finland major target for peroxynitrous acid - Prof. Michael Davies, , Denmark 12:15 – 12:45 Redox regulation of FoxO activity: impact on micronutrient More damage, longer life in C. elegans? – Prof. Jan Gruber, homeostasis - Prof. Lars-Oliver Klotz, University of Jena, National University of Singapore, Singapore Germany 12:45 – 13:45 Lunch with Posters (Aula, Castle) 13:45 – 14:30 SFRR Europe Clinical Science Lecture - Sponsored by DSM (Euro-Forum) Chairs: Prof. Juan Sastre, University of Valencia, Spain and Prof. Giuseppe Poli, University of Torino, Italy 13:45 – 14:30 Protein misfolding in the ER and oxidative stress synergize to promote cell death – Prof. Randal Kaufman, Sanford Burnham Institute of Medical Research, La Jolla, USA 14:30– 16:30 Symposium 3 - The Endoplasmic Reticulum as a Transducer of Redox Regulation and Cell Survival in Health and Disease (Euro- Forum) Chairs: Prof. Giovanni Mann and Dr. Sarah J. Chapple, King's College London, London, UK 14:30 – 15:00 Role of molecular chaperones in protein folding in health and disease - Dr. Mark Hipp, Max Planck Institute of Biochemistry, Martinried, Germany 15:00– 15:30 The challenge of maintaining redox balance during protein folding - Prof. Neil Bulleid, University of Glasgow, UK 15:30 – 16:00 Protein misfolding and ER stress in malignancy - Prof. Stefan Marciniak, Cambridge Institute for Medical Research (CIMR), Cambridge, UK 16:00 – 16:30 Endoplasmic reticulum stress during development and progression of diabetes mellitus - Prof. Peter Arvan, University of Michigan Health System, USA 16:30 – 18:30 Poster Presentations with Drinks (Aula, Castle) 18:30 – 19:30 SFRR-E General Assembly (HS 4, Castle) SNFS General Assembly (HS 1, Castle) 20:30 – open Gala Dinner at Mash Stuttgart (Bosch Areal, Forststr. 7, 70174 Stuttgart) end

Friday, 4 September 2015 07:30 SFRR-E/SNFS Conference Registration Opens (Euro-Forum) 08:00 – 10:00 Symposium 4 - Role of defective redox signalling in ageing (Euro-Forum) Chairs: Prof. Malcolm Jackson, University of Liverpool, UK and Prof. Jose Vina, University of Valencia, Spain 08:00 – 08:30 Mitochondrial oxidative stress in skeletal muscle and cardiac aging - Dr. David Marcinek, University of Washington, USA 08:30 – 09:00 Redox control of FOXO through disulfide-dependent heterodimerization - Dr. Tobias Dansen, University Medical Center Utrecht, The Netherlands 09:00 – 09:30 Redox proteomic approaches to understanding age-related changes in redox signalling - Dr. Brian McDonagh, University of Liverpool, UK 09:30 – 10:00 APC/Cdh E3 ubiquitin ligase in the pathophysiology of Alzheimer's disease - Prof. Jose Vina, University of Valencia, Spain Location: HS 1 (Hohenheim Castle) HS 4 (Hohenheim Castle) 10:00 – 10:30 Coffee break (Aula, Castle) 10:30 – 11:30 Session 5: Redox-active vitamins (HS 1, Castle) Session 6: Oxygen Club of California-sponsored Chairs: Prof. Jan Frank, University of Hohenheim, Germany and symposium on Oxygen biology (HS 4, Castle) Dr. Niki Chondrogianni, National Hellenic Research Foundation, Chairs: Prof. Enrique Cadenas, University of Greece Southern California, USA

10:30 – 11:00 Genetic variants involved in interindividual variability in Oxygen sensing by the Na,K-ATPase: the cellular mechanism vitamin E bioavailability – Dr. Charles Desmarchelier, unraveled – Dr. Anna Bogdanova, University of Zürich, INRA/University of Marseille, France Switzerland 11:00 – 11:30 Methylation at positon 7’ but not 5’ and the isoprenoid chain Precision control of dissolved oxygen in mammalian cell are required for vitamin E to induce P-glycoprotein protein culture media impacts on in situ volatile generation and expression and activity in the human colon carcinoma cell line promotes improved mesenchymal stem cell yield LS180 – Dr. Maren Podszun, University of Hohenheim, accompanied by reduced transcriptional variability – Dr. Germany Nicholas Forsyth, Keele University, United Kingdom 11:30 – 12:00 Nitrite supports neurovascular coupling via redox cycling with Systems biology of oxidative stress: first insights in lipid ascorbate – Prof. João Laranjinha, University Coimbra, Portugal oxidation and protein modification cross-talks – Dr. Maria Fedorova, University of Leipzig, Germany 12:00 – 13:00 Lunch break (Aula, Castle) 13:00 – 13:45 SFRR Europe Basic Science Lecture - Sponsored by Elsevier (Euro-Forum) Chairs: Prof. Daniela Caporossi, University of Rome, Italy and Dr. Corinne Spickett, Aston University, United Kingdom

13:00 – 13:45 Untangling H2O2 toxicity from its regulatory functions using 2-Cys peroxiredoxins and linked reductases network – Dr. Michel Toledano, Université Paris-Sud CEA-Saclay, France 13:45 – 14:30 SNFS Advances in Nutrition Lecture - Sponsored by SNFS (Euro-Forum) Chair: Prof. Helmut Sies, University of Düsseldorf, Germany 13:45 – 14:30 Antioxidants and human disease, the value of cell culture and animal models – Prof. Barry Halliwell, National University of Singapore, Singapore 14:30 – 16:30 Symposium 5 - Protein Oxidation and Repair (Euro-Forum) Chairs: Prof. Willem Koppenol, ETH Zürich, Switzerland and Prof. Christine Winterbourn, University of Otago, Christchurch, New Zealand 14:30– 15:00 Why speed matters: understanding key mechanisms of protein modification - Prof. Michael Davies, University of Copenhagen, Denmark 15:00 – 15:30 Superoxide-mediated post-translational modification of tyrosine residues - Dr. Peter Nagy, National Institute of Oncology, Hungary 15:30 – 16:00 Radical addition, a forgotten path to post-translational modification - Dr. Thomas Nauser, ETH Zürich, Switzerland 16:00 – 16:30 The good and bad sides of thiols as one-electron donors in free radical processes - Prof. Christian Schoneich, University of Kansas, USA 16:30 – 16:45 Closing Comments and Poster Prizes (Euro-Forum) – Prof. Jan Frank, President of SNFS, Meeting Chairman, University of Hohenheim, Germany