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000Cancer Coverlignes 081014.Indd KI-NA-23471-EN-C CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME (2002-2006) ???????? Cancer is a complex disease with multiple causation, complex inter- actions at the cell, organism but also at population level. At the same time a challenge for interdisciplinary research collaborative from basic to transnational and clinical level to understand better, to integrate scientifi c expertise from the laboratory to the clinic, to validate new innovative tools for detection and early prognosis, to prevent and cure. The present catalogue includes 108 projects, related to cancer research, includes 1 500 researchers from Europe and beyond who through their research projects participate to the ‘Combating Cancer initiative’ part of the EU’s combating major diseases research in the Sixth framework programme. These projects are in the forefront of European collaborative research and are currently providing information, progress and achievements CANCER RESEARCH CANCER RESEARCH on scientifi c knowledge in cancer research. CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME 2002-2006 PROJECT SYNOPSES PROJECT Interested in European research? Research*eu is our monthly magazine keeping you in touch with main developments (results, programmes, events, etc.). It is available in English, French, German and Spanish. A free sample copy or free subscription can be obtained from: European Commission Directorate-General for Research Communication Unit B-1049 Brussels Fax (32-2) 29-58220 E-mail: [email protected] Internet: http://ec.europa.eu/research/research-eu HOW TO OBTAIN EU PUBLICATIONS Our priced publications are available from EU Bookshop (http://bookshop.europa.eu/), where you can place an order with the sales agent of your choice. The Publications Offi ce has a worldwide network of sales agents. You can obtain their contact details by sending a fax to (352) 29 29-42758. European Commisssion Directorate-General for Research Directorate F – Health Unit F.2 – Medical and Public Health Research Area: Cancer Contact: Dominika Trzaska E-mail: [email protected] European Commission Offi ce CDMA 2/46 B – 1049 Brussels CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME (2002-2006) Edited by ELENGO MANOUSSAKI 2008 Directorate-General for Research – Medical and Public Health Research EUR 23471 EN Acknowledgements The catalogue has been produced thanks to the input of the coordinators involved in FP6 research, to the colleagues from Genomics and System Biology, Health Biotechnology and Horizontal aspects units of Health Directory. To the continuous encouragement of Manuel Hallen and dedication of Maria Vidal-Ragout. However, it would not have been possible to conceive and produce the catalogue without the input of colleagues who left, and new colleagues who arrived, especially: Olaf Kelm, Stefan Junglbluth, Christel Jaubert, Joana Namorado, Cornelius Schmaltz, Jessica Tengelidou, Dominika Trzaska, Alfredo Cesario and Jan van de Loo. Elengo Manoussaki Europe Direct is a service to help you fi nd answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers or these calls may be billed. LEGAL NOTICE Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. The views expressed in this publication are the sole responsibility of the author and do not necessarily refl ect the views of the European Commission. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server (http://europa.eu.int). Cataloguing data can be found at the end of this publication. Luxembourg: Offi ce for Offi cial Publications of the European Communities, 2008 ISBN 978-92-79-09352-4 © European Communities, 2008 Reproduction is authorised provided the source is acknowledged. Printed in Belgium PRINTED ON WHITE CHLORINE-FREE PAPER TABLE OF CONTENTS FOREWORD – CANCER: COMBATING A COMPLEX DISEASE 7 Biology 9 Aetiology 85 Prevention 97 Early detection, Diagnosis and prognosis 105 Treatment 161 Cancer control, Survivorship, and outcomes research 231 Scientifi c model systems 243 Indices – Keywords 250 Indices – Partners 254 Indices – Organisations 264 Contact details for activities related to cancer research European Commission Directorate General Research Directorate Health – F Unit Medical and Public Research-F2 MANUEL HALLEN, Acting Director, Health Directorate ([email protected]) MARIA JOSE VIDAL-RAGOUT, PhD, Deputy Head of unit ([email protected]) ALFREDO CESARIO, MD, Scientifi c Offi cer, SNE ([email protected]) ELENGO MANOUSSAKI, PhD, Scientifi c Offi cer ([email protected]) DOMINIKA TRZASKA, PhD, Scientifi c Offi cer ([email protected]) JAN-WILLEM VAN DE LOO, PhD, Scientifi c Offi cer ([email protected]) 3 TABLE OF CONTENTS Biology 9 Active p53 10 ANGIOTARGETING 13 Anti-tumour targeting 15 BRECOSM 17 CAPPELLA 19 COMBIO 2 1 CONTICANET 23 DIAMONDS 26 DNA Repair 28 ENLIGHT 30 EPISTEM 32 EPITRON 34 EuroBoNeT 36 EuroCSC 38 GROWTHSTOP 40 INTACT 42 KidsCancerKinome 45 Lymphangiogenomics 47 MetaBre 49 MitoCheck 51 MOL CANCER MED 53 MSCNET 55 Mutp53 57 Nano4Drugs 60 ONCASYM 62 ONCODEATH 64 PRIMA 66 Regulatory Genomics 68 SENECA 70 SIROCCO 72 SMARTER 75 TCAC in Cancer 77 THOVLEN 79 TransDeath 81 TRKCancer 82 Tumour-Host Genomics 83 Aetiology 85 AIDIT 86 CARCINOGENOMICS 88 GenoMEL 91 INCA 93 POLYGENE 95 4 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME Prevention 97 EPIC 98 EUROCADET 100 MAMMI 102 Early Detection, Diagnosis and Prognosis 105 BAMOD 106 BioCare 108 BMC 1 1 1 CANCERDEGRADOME 113 COBRED 116 DASIM 118 DISMAL 119 DNA METHYLATION 121 Drop-Top 123 E.E.T.-Pipeline 127 eTUMOUR 129 GLYFDIS 131 HI-CAM 133 HighReX 135 MCSCs 137 MMR-related cancer 139 MolDiag-Paca 140 NEMO 142 OVCAD 144 P-MARK 146 POC4life 148 PROMET 150 PROTHETS 153 STROMA 155 TRANSFOG 157 Treatment 161 ANGIOSKIN 162 ANGIOSTOP 164 Apotherapy 166 ATTACK 168 BACULOGENES 170 CancerGrid 172 CANCERIMMUNOTHERAPY 175 CHEMORES 177 CHILDHOPE 179 DC-THERA 182 DC-VACC 184 Dendritophages 186 DEPPICT 188 TABLE OF CONTENTS 5 EMIL 190 ENACT 194 European LeukaemiaNet 196 European MCL Network 201 EUROXY 203 FIRST 205 GIANT 207 HERMIONE 209 Immuno-PDT 2 1 1 LIGHTS 213 MAESTRO 215 TEMPO 217 THERADPOX 219 TRANSBIG 222 TRIDENT 225 VITAL 227 Cancer control, Survivorship and outcomes research 231 CCPRB 232 EPCRC 234 EUROCAN+PLUS 236 EUSTIR 238 NORMOLIFE 240 Scientifi c Model Systems 243 ESBIC-D 244 ZF-TOOLS 246 6 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME CANCER: COMBATING A COMPLEX DISEASE Human cancer is one of the oldest documented diseases. The oldest written evidence of the disease is found in Egyptian papyri from the period 3000 to 1500 BC which describe ulcers and breast cancer. The oldest specimen is a bronze age (1900-1600 BC) female skull suggesting head and neck cancer, whereas skeletal remains of a Peruvian – INCA – woman suggest melanoma. Breast cancer, melanoma, as well as head and neck cancer and other solid cancers, are still present across the world today. Cancer is an increasingly important health burden, both for patients and public health systems with signifi cant societal and psychological consequences. In recognition of this, a global eff ort to fi ght and control cancer has been set. Recently, the European Parliament published a resolution on Combating cancer in the enlarged Europe(1) and the council of the European Union in its conclusions on reducing the burden on cancer(2), invited the European Commission to extend knowledge of cancer epidemiology and cancer risk factors, early detection, diagnosis, treatment, survival and palliative care, as well as to include translational research under the Seventh Framework Programme. In addition, the World cancer declaration 2008, calls for a concerted strategic action to reduce the global cancer burden and outlines the steps needed to begin to reverse the global cancer crisis by 2020. Moreover, it sets specifi c priority actions on health policy, prevention and early detection, cancer treatment, and cancer research(3). The European Union’s strong research community is well placed to advance the understand- ing and treatment of cancer. Traditional approaches such as surgery, radiotherapy and chemotherapy are constantly improving, whilst genomic and immunological research off er innovative prospects for future treatment. In addition, new screening and detection methods are making it possible to confront the disease at an increasingly early stage. Furthermore, palliative care is increasingly recognised as important in ensuring cancer patients and their families to receive the best possible care and quality of life. The European Union supports cancer research in order to prevent cancer and to improve patients’ survival chances and their quality of life. The ‘Combating Cancer’ initiative was part of the EU’s Combating Major Diseases research. Within the ‘Life Sciences, Genomics and Bio- technology for Health’ thematic priority of the Sixth Framework Programme, 2002-2006 some € 480 million of funding for cancer research has been made available to the European research community through the programme. It aimed to combat cancer by developing improved patient-oriented strategies, from prevention to earlier and more eff ective
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