Principal investigator – Curriculum vitae and publications
Bergljót Magnadóttir, M.Sc., Ph.D. http://www.hi.is/gadus
FORMAL EDUCATION
"Humoral immune parameters of teleost fish", 99 p. and 9 papers. 1981: M.Sc. from the Queen's University of Belfast, Belfast, Northern Ireland (for independent studies). Thesis: "An Experimental Study of Antigens Used in the Serological Diagnoses of Johne's Disease (Paratuberculosis)", 221 p. 1969: B.Sc. Honours in Zoology from the Queen's University of Belfast, Belfast, Northern Ireland. Thesis: "Heavy metals in electron microscopy", 53 p.
EMPLOYMENT
From 2003: Head of the Department of Virology and Molecular Biology, Institute for Experimental Pathology, University of Iceland From 1972: Research position at the Institute for Experimental Pathology, University of Iceland, Keldur v. Vesturlandsveg, Iceland. Main research areas in recent years: Fish immunology, the main species studied: Atlantic cod, Atlantic salmon, Atlantic halibut, haddock and sea bass. In the last few years the main emphasis has been on studies of cod (Gadus morhua L.). From 1984 - 1985: Part time employment at The Rheumatology Research Centre, University Hospital of Wales, Cardiff for Dr. B. Williams. From 1969 - 1972: Research assistant to Dr. N. Blumson, Department of Biochemistry, The Queen's University of Belfast.
OTHER ACTIVITIES
Projects: Iceland’s representative in EU project: FISHAID (QLK2-2000-01076) 2000 – 2004 “Stimulation of fish larvae defence mechanisms against infectious diseases”, FISHAID; co-ordinator Roy Dalmo, Tromsø, Norway. Other participants: Tim Bowden and Ian Bricknell, Aberdeen, Scotland, Giuseppe Scapigliati, Viterbo, Italy and Jan Rombout, Wageningen, Holland. In Iceland: Sigríður Guðmundsdóttir, Keldur. October 1998: Spent one month at the Glycobiology Institute, University of Oxord at the invitation of Dr. Pauline Rudd, carrying out glycoanalysis of fish IgM. Co-ordinator of a Nordic project supported by the Nordic Council of Ministers 1996 – 1998: "The influence of environment and pathogens on the immune system of cod (Gadus morhua L.)". Other participants: Trond Jörgensen, Tromsø, Norway and Lars Pilström, Uppsala, Sweden. In Iceland: Sigurður Helgason and Sigríður Guðmundsdóttir, Keldur.
Invited or plenary speaker: Invited speaker at 3 universities in China in May 2009: o College of Veterinary Medicine, China Agricultural University, Beijing (inv. by Professor Chun Xia), o Tianjin Normal University, Tianjin (inv. by Professor Jinsheng Sun) and o Department of Marine Biology, Ocean University of China, Qingdao (inv. by Professor Shicui Zhang). Cod Farming in the Nordic Countries, International conference, Grand Hotel, Reykjavik, 30.9. – 1. 10. 2008 International conference on Fish Diseases and Fish Immunology, Keldur’s 60th anniversary, Reykjavík 6. – 9. September 2008. AIF Cod Pathway to Commercialization, international conference at the Memorial University, St John’s, Canada, 16. – 17. Oct. 2007. 6th International Symposium on Fish Immunology, May 24 – 29, 2004, University of Turku,Turku, Finland. Vísindafélag Íslendinga (Societas Scientiarum Islandica) 29. 1. 2004.
Students: From 2009: Sigríður Steinunn Auðunsdóttir, M.S. student (supervisor). 2006 - 2008: Berglind Gísladóttir M.S. student (advisor). 2002 - 2005: Sigrúnar Lange PhD student (supervisor). 2002 - 2005: Sædís Sævarsdóttur PhD student (committee member). 1999 - 2001: Sigrúnar Lange M.S. student (supervisor).
PUBLICATIONS (in peer reviewed journals from 1987 - 2009)
Magnadottir, B. (2010). Humoral response in early stages of infection of cod (Gadus morhua L.) with atypical furunculosis. Icelnadic Agricultural Science, being reviewed. Magnadottir, B. (2010). Review: Immunological control of fish diseases, Marine Biotechnology in press. 10.1007/s10126-010-9279-x Magnadottir, B. Gudmundsdottir, S., Gudmundsdottir, B.K., Sigurdsson, H. (2009). Natural antibodies of cod (Gadus morhua L.): Specificity, activity and affinity. Comp. Biochem. Physiol. Part B. 154:309-316. Gudmundsdottir, S., Magnadottir, B., Björnsdottir, B., Arnadottir, H., Gudmundsdottir, B.K. (2009). Specific and natural antibody response of cod juveniles vaccinated against Vibrio anguillarum. Fish & Shellfish Immunology, 26: 619-624. Gisladottir B., Gudmundsdottir S, Brown L, Jonsson Z O, Magnadottir B. (2009). Isolation of two C- reactive protein homologues from cod (Gadus morhua L.) serum. Fish & Shellfish Immunology 26: 210-219. Magnadóttir, B. (2006) Innate immunity of fish (overview). Fish & Shellfish Immunology. 20: 137- 151. Hui KM, Magnadottir B, Schifferli JA, Inal JM. (2006). CRIT peptide interacts with factor B and interferes with alternative pathway activation. Biochem Biophys Res Commun.344: 308 – 314. Magnadóttir, B., Guðmundsdóttir, B.K., Lange, S., Bambir, S.H., Steinarsson, A., Oddgeirsson, M., Bowden, T., Bricknell, I., Dalmo, R., Guðmundsdóttir, S. (2006). Immunostimulation of cod (Gadus morhua L.) larvae and juveniles. Journal of Fish Diseases 26:147-155. Lange, S., Bambir, S. H., Dodds, A. W., Bowden, T., Bricknell, I., Espelid, S., Magnadóttir (2006). Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae. Fish & Shellfish Immunology. 20:285-294. Kwok-Min Hui, G. L. Orriss, T. Schirmer, B. Magnadóttir, J. A. Schifferli, J. M. Inal (2005). Expression of functional recombinant von Willebrand factor-A domain from human complement C2: a potential binding site for C4 and CRIT. Biochem. J. 389: 863-868. Lange, S. Dodds, A. W., Gudmundsdóttir, S., Bambir, S. H., Magnadóttir, B. (2005). The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.) – a role in development and homeostasis? Developmental and Comparative Immunology. 29:1065-1077. Magnadottir, B., S. Lange, S. Gudmundsdottir, J. Bøgwald, R.A. Dalmo (2005). Ontogeny of humoral immune parameters in fish. Fish & Shellfish Immunology (special issue). 19: 429-439. Björnsdóttir, B., S. Guðmundsdóttir, S. H. Bambir, B. Magnadóttir, B. K. Guðmundsdóttir (2004). Experimental infection of turbot, Scophthalmus maximus (L.), by Moritella viscosa, vaccination effort and vaccine-induced side-effects. J. Fish Dis. 27: 1-11. Magnadóttir B, Lange S, Steinarsson A, Gudmundsdóttir S. (2004) The ontogenic development of innate immune parameters of cod (Gadus morhua L.). Comp Biochem Biophys PartB 139:217- 224. Lange, S., Bambir, S., Dodds, A. W., Magnadóttir, B.(2004). An immunohistochemical study on complement component C3 in juvenile Atlantic halibut (Hippoglossus hippoglossus L.). Developmental and Comparative Immunology 28:593-601. Magnadóttir, B., Lange, S. (2004). Is apolipoprotein A-I a regulating protein for the complement system of cod (Gadus morhua L.)? Fish & Shellfish Immunology 16:265-269. Lange, S., Dodds, A. W., Magnadóttir, B.(2004). Isolation and Characterisation of Complement Component C3 from Atlantic Cod (Gadus morhua L.) and Atlantic Halibut (Hippoglossus hippoglossus L.). Fish & Shellfish Immunology 16: 227-239. Lange, S., Bambir, S., Dodds, A. W., Magnadóttir, B.(2004). The ontogeny of complement component C3 in Atlantic cod (Gadus morhua L.) – an immunohistochemical study. Fish & Shellfish Immunology 16:359-367. Lange, S., Magnadóttir, B. (2003). Spontaneous haemolytic activity of Atlantic halibut (Hippoglossus hippoglossus L.) and Sea Bass (Dicentrarchus labrax) serum. Comparative Biochemistry and Physiology 136:99-106. Gudmundsdóttir, S., Lange, S., Magnadóttir, B. and Guðmundsdóttir, B. K. (2003) Protection against atypical furunculosis in Atlantic halibut, Hippoglossus hippoglossus (L.); comparison of a commercial furunculosis vaccine and an autogenous vaccine. J. Fish Diseases, 26: 331-338. Magnadóttir, B., Bambir, SH, Guðmundsdóttir, BK, Pilström, L., Helgason, S. Atypical Aeromonas salmonicida infection in naturally and experimentally infected cod, Gadus morhua L. J. Fish Diseases, 25: 583-597, 2002. Bergljót Magnadóttir, Max Crispin, Louise Royle, Cristina Colominas, David J. Harvey, Raymond A. Dwek, Pauline M. Rudd. The carbohydrate moiety of serum IgM from cod (Gadus morhua L.). Fish & Shellfish Immunology 12: 209 – 227, 2002. Lange, S., Guðmundsdóttir, B. K., Magnadóttir, B. Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.). Fish & Shellfish Immunology, 11 (6): 523 – 534, 2001 Magnadóttir, B., Jónsdóttir, H., Helgason, S., Björnsson, B., Solem, S. T., Pilström. L. Immune parameters of immunized cod (Gadus morhua L.). Fish & Shellfish Immunology, 11: 75 - 89, 2001. Magnadóttir, B. The spontaneous haemolytic activity of cod serum: Heat insensitivity and other characteristics. Fish & Shellfish Immunology, 10: 731 - 735, 2000. Magnadóttir, B., Halla Jónsdóttir, Sigurður Helgason, Björn Björnsson, Trond Jørgensen, Lars Pilström, 1999. Humoral immune parameters in Atlantic cod (Gadus morhua L.) I: The effects of environmental temperature. Comparative Biochemistry and Physiology, 122B: 173 - 180, 1999. Magnadóttir, B., Halla Jónsdóttir, Sigurður Helgason, Björn Björnsson, Trond Jørgensen, Lars Pilström, 1999. Humoral immune parameters in Atlantic cod (Gadus morhua L.) II: The effects of size and gender under different environmnetal conditions. Comparative Biochemistry and Physiology 122B: 181 - 188, 1999. Widholm, H., Lundback, A. -S., Magnadóttir, B., Warr, G. W., Pilström, L. 1999. The variability of the immunoglobulin light chain in Atlantic cod (Gadus morhua L.). Developmental and Comparative Immunology, 23: 231 - 240, 1999. Magnadóttir, B. 1998. Comparison of immunoglobulin (IgM) in four fish species. Icel. Agr. Sci. 12: 47 - 59. Magnadóttir, B., Jónsdóttir, H., Helgason, S., Jørgensen,T., Pilström, P. Optimisation of ELISA used to measure total IgM and antibody activity in different groups of cod. "Methodology in Fish Diseases Research", ritstjórar: A. C. Barnes, G. A. Davidson, M. P. Hiney, D. McIntosh, 1998, bls. 105 - 110. Magnadóttir, B., Guðmundsdóttir, S., Guðmundsdóttir, B.K., 1997. The carbohydrate moiety of IgM from salmon (Salmo salar L.). Comp. Biochem. Physio.116B: 423 - 430, 1997 Guðmundsdóttir, B. K., Magnadóttir, B. 1997. Protection of Atlantic salmon (Salmo salar L.) against an experimental infection of Aeromonas salmonicida ssp. achromogenes. Fish & Shellfish Immunol.7, 55 - 69. Guðmundsdóttir, B. K., Jónsdóttir, H., Steinþórsdóttir, V., Magnadóttir, B., Guðmundsdóttir, S. 1997. Survival and humoral antibody response of Atlantic salmon (Salmo salar L.) vaccinated against Aeromonas salmonicida subsp. achromogenes. J. Fish Dis. 20, 351 - 360. Magnadóttir, B., B. K. Guðmundsdóttir and S. Guðmundsdóttir, The carbohydrate moiety of IgM from Atlantic salmon, Salmo salar L. Grein í fullri lengd ásamt myndum birt á alnetsráðstefnunni: Second Electronic Glycoscience Conference (EGC-2) 9. 9. - 20. 9. 1996, http://bellatrix.pcl.ox.ac.uk/egc2/ Guðmundsdóttir,B.K., S. Guðmundsdóttir, B. Magnadóttir, S. Helgason. 1996. Rannsóknir á bakteríusjúkdómum í laxfiskum. Læknablaðið, 82: 72 - 77. Magnadóttir, B., Kristjánsdóttir, H., Guðmundsdóttir, S. 1996. Characterisation of monoclonal antibodies to separate epitopes on salmon IgM heavy chain. Fish & Shellfish Immunol. 6: 185 - 198. Magnadóttir, B., Guðmundsdóttir, S., Guðmundsdóttir, B.K., 1995. Study of the humoral response of Atlantic salmon (Salmo salar L.), naturally infected with Aeromonas salmonicida ssp. achromogenes. Vet. Immunol. Immunopathol. 49: 127 - 142. Guðmundsdóttir, S., Magnadóttir, B., Guðmundsdóttir, B., 1995. Effects of antigens from Aeromonas salmonicida ssp. achromogenes on primed and unprimed leukocytes from Atlantic salmon (Salmo salar L.). Fish & Shellfish Immunol. 5: 493 - 504. Magnadóttir, B., Guðmundsdóttir, B.K., 1992. A comparison of total and specific immunoglobulin levels in healthy Atlantic salmon (Salmo salar L.) and in salmon naturally infected with Aeromonas salmonicida subsp. achromogenes. Vet. Immunol. Immunopatholgy, 32, 179 - 189. Magnadóttir, B. 1990. Purification of immunoglobulin from the serum of Atlantic salmon (Salmo salar L.). Icel. Agr. Sci. 4: 49 - 54. Andrésdóttir, V., Bergljót Magnadóttir, Ólafur S. Andrésson, Guðmundur Pétursson, 1987: "Subclasses of IgG from Whales", Devel. Comp. Immunol. 11, 801 - 806.
THESES
Bergljót Magnadóttir, 2000: "Humoral immune parameters of teleost fish" Ph.D. Department of Medicine, University of Iceland, Jan. 2000, pp. 99 and 9 papers. Bergljót Magnadóttir, 1981: "An Experimental Study of Antigens Used in the Serological Diagnoses of Johne's Disease (Paratuberculosis)". M.Sc. (for independent research), Queen's University of Belfast, pp. 221. Bergljót Magnadóttir, 1969: "Heavy metals in electron microscopy". B.Sc. hon. Queen's University of Belfast, pp. 53.