BMC Molecular Biology BioMed Central Research article Open Access The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals Rebecca S LaRue1, Stefán R Jónsson1,2, Kevin AT Silverstein3, Mathieu Lajoie4, Denis Bertrand4, Nadia El-Mabrouk4, Isidro Hötzel5, Valgerdur Andrésdóttir2, Timothy PL Smith6 and Reuben S Harris*1 Address: 1Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA, 2University of Iceland, Institute for Experimental Pathology, Keldur v/Vesturlandsveg, 112 Reykjavík, Iceland, 3Masonic Cancer Center, Biostatistics and Bioinformatics Group, University of Minnesota, Minneapolis, Minnesota 55455, USA, 4DIRO, Université de Montréal, Montréal, Quebec, H3C 3J7, Canada, 5Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040, USA and 6USDA/ARS US Meat Animal Research Center, Genetics and Breeding Research Unit, PO Box 166, Clay Center, Nebraska 68933-0166, USA Email: Rebecca S LaRue -
[email protected]; Stefán R Jónsson -
[email protected]; Kevin AT Silverstein -
[email protected]; Mathieu Lajoie -
[email protected]; Denis Bertrand -
[email protected]; Nadia El-Mabrouk -
[email protected]; Isidro Hötzel -
[email protected]; Valgerdur Andrésdóttir -
[email protected]; Timothy PL Smith -
[email protected]; Reuben S Harris* -
[email protected] * Corresponding author Published: 18 November 2008 Received: 13 August 2008 Accepted: 18 November 2008 BMC Molecular Biology 2008, 9:104 doi:10.1186/1471-2199-9-104 This article is available from: http://www.biomedcentral.com/1471-2199/9/104 © 2008 LaRue et al; licensee BioMed Central Ltd.