Cis-Regulatory Chromatin Contacts in Neural Cells Reveal Contributions
bioRxiv preprint doi: https://doi.org/10.1101/494450; this version posted February 22, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 cis-Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to 2 Complex Neurological Disorders 3 4 5 Authors: Michael Song1,2, Xiaoyu Yang1, Xingjie Ren1, Lenka Maliskova1, Bingkun Li1, Ian Jones1, 6 Chao Wang3, Fadi Jacob4,5, Kenneth Wu6, Michela Traglia7, Tsz Wai Tam1, Kirsty Jamieson1, Si-Yao 7 Lu8, Guo-Li Ming4,9,10,11, Jun Yao8, Lauren A. Weiss1,7, Jesse Dixon12, Luke M. Judge6,13, Bruce R 8 Conklin6,14, Hongjun Song4,9,10,15, Li Gan3, Yin Shen1,2,16* 9 10 11 Affiliation: 12 13 1Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA 14 2Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San 15 Francisco, San Francisco, CA, USA 16 3Gladstone Institute for Neurological Disorders, San Francisco, CA, USA 17 4Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, 18 University of Pennsylvania, Philadelphia, PA 19104, USA. 19 5The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 20 Baltimore, MD 21205, USA. 21 6Gladstone Institute for Cardiovascular Disease, San Francisco, CA, USA 22 7Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA 23 8State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life 24 Sciences, Tsinghua University, Beijing, China.
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