t05 − t00 (optimum) (only for avg squared deviation Quantile> 0.92 )

RTKN PFKFB2 SFRS11 PGRMC1 PALLD PBK GATAD2A PTPN14 BAZ1B ZC3HC1 LIG1 ZYX SORBS3 NOP58 C1orf116 RIC8A NPM3 TBC1D4 RPS6KA1 CTTN SGTA AKT1S1 TLK1 TAF3 PFKP AFF4 RB1 PDHA1 FLII RPS6KA4 RHPN2

and/or phospho modulated FLNB MELK ANXA2 PDCD4 SERBP1 GRLF1 EPB41L1 ARFIP1 RBM5 NELF RPS6KA3 CDC25B ILK BLK FES PXK JAK1 ABL1 AKT1 TYK2 RAF1 CDK6 CDK2 CDK1 CDK5 ARAF LIMK2 IRAK1 CDK16 DAPK1 SRPK1 CHEK2 MAST3 PRKCZ MAPK8 MARK3 PRKCA STK32B PRKAA1 MAP3K8 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 1.137e−02

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t05 − t00 (optimum) (only for avg squared deviation Quantile> 0.93 )

PALLD GATAD2A PBK RB1 ZC3HC1 LIG1 BAZ1B PTPN14 ZYX SORBS3 NOP58 C1orf116 RIC8A NPM3 RTKN PFKFB2 SFRS11 PGRMC1 SGTA AKT1S1 TAF3 PFKP TBC1D4 RPS6KA1 CTTN RHPN2 FLNB PDHA1 kinases and/or phospho modulated FLII RPS6KA4 MELK ANXA2 PDCD4 SERBP1 EPB41L1 RBM5 RPS6KA3 CDC25B ILK BLK FES PXK JAK1 ABL1 AKT1 TYK2 CDK6 CDK2 CDK1 CDK5 ARAF WEE1 LIMK2 IRAK1 DAPK1 CHEK2 MAST3 PRKCZ MAPK8 MARK3 PRKCA STK32B MAP3K8 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 4.799e−03

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t05 − t00 (optimum) (only for avg squared deviation Quantile> 0.94 )

PALLD GATAD2A PBK RB1 RTKN PFKFB2 SFRS11 PGRMC1 ZC3HC1 LIG1 PTPN14 BAZ1B ZYX SORBS3 NOP58 C1orf116 RIC8A NPM3 SGTA AKT1S1 TBC1D4 RPS6KA1 CTTN RHPN2 kinases and/or phospho modulated FLNB MELK ANXA2 PDCD4 RPS6KA4 PDHA1 FLII EPB41L1 CDC25B ILK BLK PXK JAK1 ABL1 AKT1 TYK2 CDK6 CDK1 CDK2 ARAF CDK5 WEE1 DAPK1 CHEK2 MAST3 PRKCZ MAPK8 PRKCA STK32B MAP3K8 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 1.628e−02

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t05 − t00 (optimum) (only for avg squared deviation Quantile> 0.95 )

PALLD

GATAD2A

PBK

RTKN

PFKFB2

SFRS11

PGRMC1

RIC8A

NPM3

NOP58

SGTA

AKT1S1

ZC3HC1

LIG1

PTPN14

BAZ1B

ZYX

SORBS3

RB1

PDHA1 kinases and/or phospho modulated FLII

RPS6KA4

MELK

ANXA2

FLNB

PDCD4

CDC25B ILK BLK JAK1 ABL1 AKT1 TYK2 CDK6 CDK1 ARAF CDK2 CDK5 WEE1 DAPK1 CHEK2 MAST3 PRKCZ PRKCA STK32B CSNK2A1 kinases ; Fisher test enrichment nonNeut: 7.905e−02

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t60 − t00 (optimum) (only for avg squared deviation Quantile> 0.92 )

TLN1 SF3B1 HNRNPU DYNC1H1 STMN1 PKN2 PBRM1 HSP90AA1 SLC9A1 GRLF1 AKT1S1 SERBP1 KIAA1598 SCRIB PTK7 TWISTNB ARHGAP5 RTKN NUAK2 NELF BRD8 REPS1 SPAG9 DDX3X HNRNPK RIC8A NOP58 SORBS3 LIG1 ZC3HC1

kinases and/or phospho modulated SFRS11 BAZ1B TPD52 PPFIA1 RRAGD SGTA TLK1 LRRFIP1 PHLDA2 AFF4 PBK GATAD2A ILK BLK PXK JAK1 ABL1 AKT1 TYK2 ARAF CDK5 CDK2 CDK1 MST4 WEE1 IRAK4 LIMK2 IRAK1 STK24 STK25 DAPK1 MAST3 PRKCZ MAPK9 MAPK3 MAPK8 AURKB PRKCA PRKAA1 ADRBK2 RPS6KA2 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 5.849e−02

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t60 − t00 (optimum) (only for avg squared deviation Quantile> 0.93 )

HNRNPU DYNC1H1 SLC9A1 AKT1S1 GRLF1 TLN1 SF3B1 PKN2 PBRM1 HSP90AA1 STMN1 SPAG9 DDX3X HNRNPK NELF BRD8 REPS1 SCRIB PTK7 SERBP1 RTKN NUAK2 TPD52 PPFIA1 RRAGD SGTA RIC8A NOP58 kinases and/or phospho modulated TLK1 PHLDA2 AFF4 SORBS3 LIG1 ZC3HC1 BAZ1B SFRS11 PBK GATAD2A ILK BLK PXK JAK1 ABL1 AKT1 TYK2 CDK1 CDK2 CDK5 ARAF MST4 WEE1 IRAK4 IRAK1 STK24 STK25 DAPK1 MAST3 PRKCZ MAPK9 MAPK3 AURKB PRKCA ADRBK2 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 7.469e−02

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t60 − t00 (optimum) (only for avg squared deviation Quantile> 0.94 )

TLN1 SF3B1 HNRNPU DYNC1H1 SLC9A1 GRLF1 AKT1S1 PKN2 PBRM1 HSP90AA1 STMN1 SPAG9 HNRNPK NUAK2 DDX3X SERBP1 BRD8 SCRIB REPS1 SORBS3 LIG1 ZC3HC1 BAZ1B RIC8A kinases and/or phospho modulated NOP58 SFRS11 TPD52 PPFIA1 RRAGD SGTA PHLDA2 PBK GATAD2A ILK PXK JAK1 ABL1 AKT1 TYK2 CDK1 CDK2 CDK5 ARAF MST4 WEE1 IRAK1 STK24 STK25 MAST3 PRKCZ MAPK9 AURKB PRKCA ADRBK2 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 1.892e−01

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8 t60 − t00 (optimum) (only for avg squared deviation Quantile> 0.95 )

TLN1

SF3B1

HNRNPU

DYNC1H1

SLC9A1

GRLF1

AKT1S1

PKN2

PBRM1

HSP90AA1

STMN1

NUAK2

DDX3X

SPAG9

HNRNPK

SORBS3

LIG1

ZC3HC1

BAZ1B

SFRS11 kinases and/or phospho modulated RIC8A

NOP58

TPD52

PPFIA1

SGTA

PBK

GATAD2A ILK JAK1 ABL1 AKT1 CDK2 CDK5 ARAF CDK1 MST4 WEE1 IRAK1 STK24 STK25 MAST3 MAPK9 AURKB PRKCA ADRBK2 CSNK2A1 kinases ; Fisher test enrichment nonNeut: 3.084e−01

−0.8 −0.6 −0.4 −0.2 0.0 0.2 0.4 0.6 0.8