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The Role of Well Water and Other Factors in the Aetiology of Parkinson’S Disease
^.,-wtM IC REGlSTRAh )0M 261 ^ER3!TY OF LONDON :«VATE HOUSE ‘LET STREET ' ’“IN WC1E7KU THE ROLE OF WELL WATER AND OTHER FACTORS IN THE AETIOLOGY OF PARKINSON’S DISEASE YOAV BEN-SHLOMO A thesis submitted for the degree of Doctor of Philosophy University College London, 2003 1 UMI Number: U602452 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U602452 Published by ProQuest LLC 2014. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 Abstract Objectives: To determine the risk of early onset Parkinson’s disease (PD) associated with well water consumption and other risk factors. Design: A case control study with strata matching by age group, gender and current urban or rural residence. Setting: Republic of Ireland, between 1993 to 1995. Participants: Cases with Parkinson’s disease, fulfilling at least two of the four cardinal features, with date of birth from 1st January 1926 and disease onset before 56 years. Controls were selected using stratified random sampling from the electoral register. Outcome measures: Odds ratio and 95% confidence interval for well water consumption and other risk factors. -
The Global State of Tobacco Harm Reduction 2018 GSTHR 1 2 GSTHR
NO FIRE, NO SMOKE: THE GLOBAL STATE OF TOBACCO HARM REDUCTION 2018 GSTHR 1 2 GSTHR No Fire, No Smoke: The Global State of Tobacco Harm Reduction 2018 Written and edited by Harry Shapiro Report and website production coordination: Grzegorz Krol The full report (pdf) is available at www.gsthr.org Country profiles are available atwww.gsthr.org To obtain a hard copy of the full report go to www.gsthr.org/contact The Executive Summary is available in various languages at www.gsthr.org/translations Copy editing and proofing: Tom Burgess, Ruth Goldsmith and Joe Stimson Project management: Gerry Stimson and Paddy Costall Report design and layout: Urszula Biskupska Website design & coding: Filip Woźniak, Vlad Radchenko Print: WEDA sc Knowledge-Action-Change, 8 Northumberland Avenue, London, WC2N 5BY © Knowledge-Action-Change 2018 Citation: No Fire, No Smoke: The Global State of Tobacco Harm Reduction 2018 (2018). London: Knowledge-Action-Change. NO FIRE, NO SMOKE: THE GLOBAL STATE OF TOBACCO HARM REDUCTION 2018 GSTHR 3 Acknowledgements 4 Executive Summary: No Fire, No Smoke: The Global State of Tobacco Harm Reduction 2018 5 Scope and terminology 8 Website 8 Updating 8 Data sources and limitations 8 Forewords: 10 Nancy Sutthoff 10 David Sweanor 10 Martin Jarvis 11 Key acronyms and abbreviations 12 Chapter 1: Introduction: tobacco harm reduction 13 Chapter 2: The continuing global epidemic of cigarette smoking 17 Chapter 3: Safer nicotine products: a global picture 22 Chapter 4: Consumers of safer nicotine products 38 Chapter 5: Safer nicotine products -
Scarica N. 3/2018 (Full)
Tabaccologia 3-2015 | xxxxxxxxxxxxxxxxx 1 3 | 2018 ANNO XVI Organo Ufficiale della Società Italiana di Tabaccologia-SITAB Official Journal of the Italian Society of Tobaccology www.tabaccologia.it Tabaccologia Poste italiane SPA Spedizione in Tobaccology Abbonamento Postale 70%-LO/BG Congresso Nazionale SITAB 2018: La tabaccologia italiana a Congresso Politici e tabacco Indipendenza delle Società e altre Istituzioni Scientifiche italiane dall’industria del tabacco Position paper sulla indipendenza delle Società Scientifiche italiane da Big Tobacco World No Tobacco Day 2018/Report ISS: tabagismo, un problema anche di cuore Report ISS/DOXA 2018 sul fumo in Italia Un modello integrato per la lotta all’uso adolescenziale di sostanze Fumo di tabacco in gravidanza e counseling ostetrico per attuare percorsi di disassuefazione Trimestrale a carattere scientifico per lo studio del tabacco, del tabagismo e delle patologie fumo-correlate Quarterly scientific journal for the study of tobacco, tobacco use and tobacco-related diseases [email protected] Morte improvvisa nell’atleta: “Eppur si muore!” A proposito Giornata Mondiale della una fatalità inevitabile? pag. 13 dei decessi per asma pag. 16 Tubercolosi pag. 19 ANNO XI N° 41 MARZO 2018 RE TRIMESTRALE DI INFORMAZIONE, PREVENZIONE E BENESSERE RESPIRONEWS.IT Trimestrale di ISSN 1970-4925 ISSN informazione, prevenzione e benessere, rivolto prevalentemente al Trimestrale per cittadino/paziente, professionisti dell’area quale strumento di Poste Italiane SpA - Sped. in A.P. - Stampe Periodiche in Regime Libero - Milano n. ... / .... (anno) - Milano n. ... / .... (anno) in Regime Libero - Stampe Periodiche Italiane SpA - Sped. in A.P. Poste pneumologica, educazione a un www.sintexservizi.it | www.sintexservizi.it strumento di formazione corretto stile di vita 7 Dalla comunicazione alla divulgazione Gli italiani sono E. -
Mortality, Survival and Incidence Rates in the ITALUNG Randomised Lung
Thorax Online First, published on April 4, 2017 as 10.1136/thoraxjnl-2016-209825 Lung cancer ORIGINAL ARTICLE Thorax: first published as 10.1136/thoraxjnl-2016-209825 on 4 April 2017. Downloaded from Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial Eugenio Paci,1 Donella Puliti,1 Andrea Lopes Pegna,2 Laura Carrozzi,3 Giulia Picozzi,4 Fabio Falaschi,5 Francesco Pistelli,3 Ferruccio Aquilini,3 Cristina Ocello,1 Marco Zappa,1 Francesca M Carozzi,6 Mario Mascalchi,7 and the ITALUNG Working Group ▸ Additional material is ABSTRACT published online only. To view Background ITALUNG is contributing to the European Key messages please visit the journal online (http://dx.doi.org/10.1136/ evaluation of low-dose CT (LDCT) screening for lung thoraxjnl-2016-209825). cancer (LC). Methods Eligible subjects aged 55–69 years, smokers For numbered affiliations see What is the key question? end of article. or ex-smokers (at least 20 pack-years in the last ▸ After the positive results of the National Lung 10 years), were randomised to receive an annual Screening Trial in the USA, the efficacy of lung Correspondence to invitation for LDCT screening for 4 years (active group) or cancer screening with low-dose CT (LDCT) is Dr Eugenio Paci, Clinical to usual care (control group). All participants were still debatable in Europe. Epidemiology Unit, ISPO— Cancer Research and followed up for vital status and cause of death (at the end of 2014) and LC incidence (at the end of 2013). What is the bottom line? Prevention Institute, Via delle ▸ fi Oblate, Florence 50144, Italy; Pathological and clinical information was collected from Despite the lack of statistical signi cance, the [email protected] the Tuscan Cancer Registry data. -
Tobacco Use Behaviors for Swedish Snus and US Smokeless Tobacco
Tobacco Use Behaviors for Swedish Snus and US Smokeless Tobacco Prepared for: Swedish Match, Stockholm, Sweden and Swedish Match North America, Richmond, Virginia Prepared by: ENVIRON International Corporation Arlington, Virginia Date: May 2013 Project Number: 2418132C Snus and US Smokeless Tobacco Contents Page Executive Summary 1 1 Introduction 6 1.1 Background 6 1.2 Literature search and methods 8 2 Temporal, Geographic and Demographic Patterns of Smokeless Tobacco Use. 10 2.1 Scandinavia 10 2.1.1 Current and Historical Temporal Trends of Swedish Snus 10 2.1.2 Geographic variations in snus use 12 2.1.3 Age and gender 12 2.1.4 Socioeconomic and occupational variations in snus 14 2.1.5 Other individual level characteristics related to snus 15 2.1.6 Exposure estimates: frequency, amount and duration of snus 15 2.2 United States 17 2.2.1 Temporal trends 18 2.2.2 Geographic variations in smokeless tobacco use 19 2.2.3 Age and gender 20 2.2.4 Race/ethnicity 21 2.2.5 Socioeconomic and occupational variations in smokeless tobacco use 22 2.2.6 Other individual level characteristics related to smokeless tobacco use 23 2.2.7 Exposure estimates: frequency, amount and duration of smokeless tobacco use 23 2.3 Summary and Conclusions 23 3 Relationship of Smokeless Tobacco to Smoking 25 3.1 Population-level transitioning between tobacco products 26 3.1.1 Scandinavia 26 3.1.2 United States 27 3.2 Individual-level transitioning between tobacco products: Gateway and transitioning from smokeless tobacco to cigarettes 27 3.2.1 Scandinavia 28 3.2.2 United States 31 3.3 Transitioning from cigarettes to smokeless tobacco and smoking cessation 35 3.3.1 Scandinavia 36 3.3.2 United States 41 3.4 Snus/Smokeless Tobacco Initiation 45 3.4.1 Scandinavia 45 3.4.2 United States 46 3.5 Dual Use 47 3.5.1 Scandinavia 47 3.5.2 United States 52 4 Summary and Conclusions 57 Contents i ENVIRON Snus and US Smokeless Tobacco 5 References 60 List of Tables Table 1: Recent Patterns of Snus Use in Sweden (Digard et al. -
Smoking Inequality Across Genders and Socio- Economic Classes
ISSN: 2281-1346 Department of Economics and Management DEM Working Paper Series Smoking Inequality across Genders and Socio- economic Classes. Evidence from Longitudinal Italian Data Cinzia Di Novi (Università degli Studi di Pavia) Rowena Jacobs (University of York) Matteo Migheli (Università di Torino and Collegio Carlo Alberto) # 152 (02-18) Via San Felice, 5 I-27100 Pavia economiaweb.unipv.it February 2018 1 Smoking Inequality across Genders and Socio-economic Classes. Evidence from Longitudinal Italian Data Cinzia Di Novia, Rowena Jacobsb, Matteo Mighelic,d* Abstract There has been a dearth of literature on smoking inequalities, in spite of its contribution to health inequalities. We exploit longitudinal Italian individual-level data to identify the main socio- demographic characteristics that determine smoking inequalities. We use the Erreygers Concentration Index to identify in which groups smoking is relatively more prevalent. We find that, among men, pro-poor prevalence is driven by members of the lower socio-economic classes, while we observe the opposite for women. We encourage policymakers to address the issue of smoking inequalities, which the current policies have largely disregarded. Keywords: smoking inequality; Italy; gender; social classes JEL Codes: I14; I18; J16 a University of Pavia, Department of Economics and Management; Health, Econometrics and Data Group, University of York, Heslington, York ,UK; Laboratory for Comparative Social Research, National Research University Higher School of Economics, Moscow, Russia. b Centre for Health Economics, University of York, Heslington, York, UK. c University of Torino, Department of Economics and Statistics, lungo Dora Siena, 100 Torino, Italy. Email: [email protected] tel: +39 011 6709630 d CeRP – Collegio Carlo Alberto, piazza Arbarello, 8 Torino, Italy *Corresponding author. -
Geographical and Socioeconomic Differences in Uptake of Pap Test and Mammography in Italy: Results from the National Health Interview Survey
Open access Research BMJ Open: first published as 10.1136/bmjopen-2018-021653 on 19 September 2018. Downloaded from Geographical and socioeconomic differences in uptake of Pap test and mammography in Italy: results from the National Health Interview Survey Alessio Petrelli,1 Paolo Giorgi Rossi,2,3 Lisa Francovich,4 Barbara Giordani,5 Anteo Di Napoli,1 Marco Zappa,6 Concetta Mirisola,1 Lidia Gargiulo4 To cite: Petrelli A, Giorgi ABSTRACT Strengths and limitations of this study Rossi P, Francovich L, Objective The Italian National Health Service instituted et al. Geographical and cervical and breast cancer screening programmes in 1999; ► The large amount of information derived from Italian socioeconomic differences the local health authorities have a mandate to implement in uptake of Pap test and National Health Interview Survey allowed us to in- these screening programmes by inviting all women aged mammography in Italy: results vestigate inequities in screening uptake in Italy thor- 25–64 years for a Pap test every 3 years (or for an Human from the National Health oughly for the first time. Papilloma Virus (HPV) test every 5 years) and women aged Interview Survey. BMJ Open ► The joint use of two data sources enabled estimating 50–69 years for a mammography every 2 years. However, 2018;8:e021653. doi:10.1136/ the impact of screening programmes on uptake in the implementation of screening programmes throughout bmjopen-2018-021653 the country, evaluating also the differences between the country is still incomplete. This study aims to: (1) Prepublication history regions and in groups with different socioeconomic ► describe cervical and breast cancer screening uptake and for this paper is available and behavioural characteristics. -
Impact of the Economic Crises on Suicide in Italy: the Moderating Role of Active Labor Market Programs
Social Psychiatry and Psychiatric Epidemiology (2019) 54:201–208 https://doi.org/10.1007/s00127-018-1625-8 ORIGINAL PAPER Impact of the economic crises on suicide in Italy: the moderating role of active labor market programs Giorgio Mattei1,2 · Barbara Pistoresi3 · Roberto De Vogli4 Received: 21 May 2018 / Accepted: 2 November 2018 / Published online: 12 November 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract Purpose To analyze the association between unemployment and suicide in Italy during the years 1990–2014, with a peculiar focus on the great recession (GR) and the role played by social protection as buffering mechanism against the negative effect on health outcomes. Methods Fixed effects panel regressions were used to assess the association between changes in unemployment rate and suicide rates. Additional models investigated the role of active labor market programs (ALMPs) as possible moderators of the association. Analyses were carried out for both males and females, stratified by age and region. Results The negative time-trend displayed by suicide rate in Italy until 2007 was slowed down by changes in unemployment at the beginning of the GR, when this trend reversed and the rate of suicide started increasing. Male workers aged 25–64 and women aged 55–64 years were affected by both “normal” unemployment rate fluctuations as well as severe economic crises. Women aged 35–44 were only influenced by the latter. Men benefit from ALMPs mainly in Central Italy, while women did not benefit significantly from ALMPs. Conclusions In Italy, economic downturns were associated with increased suicides mainly among men, while severe eco- nomic crises were associated with increased suicides among both men and women. -
The Environmental Behaviour of Polonium
technical reportS series no. 484 Technical Reports SeriEs No. 484 The Environmental Behaviour of Polonium F. Carvalho, S. Fernandes, S. Fesenko, E. Holm, B. Howard, The Environmental Behaviour of Polonium P. Martin, M. Phaneuf, D. Porcelli, G. Pröhl, J. Twining @ THE ENVIRONMENTAL BEHAVIOUR OF POLONIUM The following States are Members of the International Atomic Energy Agency: AFGHANISTAN GEORGIA OMAN ALBANIA GERMANY PAKISTAN ALGERIA GHANA PALAU ANGOLA GREECE PANAMA ANTIGUA AND BARBUDA GUATEMALA PAPUA NEW GUINEA ARGENTINA GUYANA PARAGUAY ARMENIA HAITI PERU AUSTRALIA HOLY SEE PHILIPPINES AUSTRIA HONDURAS POLAND AZERBAIJAN HUNGARY PORTUGAL BAHAMAS ICELAND QATAR BAHRAIN INDIA REPUBLIC OF MOLDOVA BANGLADESH INDONESIA ROMANIA BARBADOS IRAN, ISLAMIC REPUBLIC OF RUSSIAN FEDERATION BELARUS IRAQ RWANDA BELGIUM IRELAND SAN MARINO BELIZE ISRAEL SAUDI ARABIA BENIN ITALY SENEGAL BOLIVIA, PLURINATIONAL JAMAICA SERBIA STATE OF JAPAN SEYCHELLES BOSNIA AND HERZEGOVINA JORDAN SIERRA LEONE BOTSWANA KAZAKHSTAN SINGAPORE BRAZIL KENYA SLOVAKIA BRUNEI DARUSSALAM KOREA, REPUBLIC OF SLOVENIA BULGARIA KUWAIT SOUTH AFRICA BURKINA FASO KYRGYZSTAN SPAIN BURUNDI LAO PEOPLE’S DEMOCRATIC SRI LANKA CAMBODIA REPUBLIC SUDAN CAMEROON LATVIA SWAZILAND CANADA LEBANON SWEDEN CENTRAL AFRICAN LESOTHO SWITZERLAND REPUBLIC LIBERIA SYRIAN ARAB REPUBLIC CHAD LIBYA TAJIKISTAN CHILE LIECHTENSTEIN THAILAND CHINA LITHUANIA THE FORMER YUGOSLAV COLOMBIA LUXEMBOURG REPUBLIC OF MACEDONIA CONGO MADAGASCAR TOGO COSTA RICA MALAWI TRINIDAD AND TOBAGO CÔTE D’IVOIRE MALAYSIA TUNISIA CROATIA MALI -
Swedish Tobacco Control-20Sid.Indd
Swedish Tobacco Control Progress & Challenge – both are greater than ever 2006 CONTENTS The Minister’s View The Voice of NGOs Snus is Harmful A Focus on Youth 1 June 2005 – Smoke-free Sweden Innovative Tobacco Cessation The Cost-Effective Quitline International Challenges Margaretha – Luther Terry Award Winner Meet the Swedish Network Photo: Åsa Till Swedish Beware of the Trojan horse… MORGAN JOHANSSON, SWEDEN’S MINISTER OF PUBLIC HEALTH: “The statistics on our smoking behaviours in Sweden are looking better and better every year, and I “We will be following believe that the new smoking ban is contributing to the continued decline.” Morgan Johansson, Minister of Public Health developments closely” Photo: Pawel Flato » Public Health Goals for the year 2014 “The ban on smoking in dining and drinking establishments that went into risks of smoking are much greater,” tobacco activity in their public health effect on 1 June 2005 is probably one of our most popular reforms,” says says Mr. Johansson. “However, there programmes. Reducing tobacco use is one of the primary are also health risks with snus and it is “We will be following develop- Morgan Johansson, Sweden’s Minister of Public Health, when he summarizes goals for public health set by the Swedish » best to stop using tobacco entirely. ments closely to make sure that there Parliament. It includes the following interim the current state of tobacco prevention in Sweden. “We are also striving to bring about are no cutbacks in that regard,” says targets: a reduction in the use of snus. For that Mr. Johansson. “In addition, the state purpose, it is necessary to provide in- must also provide fairly substantial • A tobacco-free start in life, effective by He states that, after nearly one year formation in the schools and other long-term resources for the work of the year 2014. -
Predictors of Smoking Cessation a Longitudinal Study in a Large Cohort
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Landspítali University Hospital Research Archive Respiratory Medicine 132 (2017) 164–169 Contents lists available at ScienceDirect Respiratory Medicine journal homepage: www.elsevier.com/locate/rmed Predictors of smoking cessation: A longitudinal study in a large cohort of T smokers ∗ Mathias Holma, , Linus Schiölera, Eva Anderssona, Bertil Forsbergb, Thorarinn Gislasonc,d, Christer Jansone, Rain Jogif, Vivi Schlünsseng,h, Cecilie Svanesi,j, Kjell Toréna,k a Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden b Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umea University, Umea, Sweden c Medical Faculty, University of Iceland, Reykjavik, Iceland d Department of Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland e Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden f Lung Clinic, Tartu University Hospital, Tartu, Estonia g Department of Public Health, Section for Environment, Occupation and Health, Aarhus University, Aarhus, Denmark h National Research Centre for the Working Environment, Copenhagen, Denmark i Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway j Centre for International Health, University of Bergen, Bergen, Norway k Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, -
Parkinson's Disease?
J7ournal ofNeurology, Neurosurgery, and Psychiatry 1996;61:4-16 NEUROEPIDEMIOLOGY J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.61.1.4 on 1 July 1996. Downloaded from How far are we in understanding the cause of Parkinson's disease? Y Ben-Shlomo generate suffi- ... the writer will repine at no censure which to have a large sample size to the precipitate publication of mere conjectural cient cases for analysis. The combined alumni suggestions may incur: but shall think himself cohorts of Harvard and Pennsylvania colleges fully rewarded by having excited the attention of consisted of 50 000 people and only generated those, who may point out the most appropriate Older cohorts will be more efficient means of relieving a tedious and most distress- 160 cases.6 ing malady. in terms of statistical power. Case- James Parkinson' control studies, although far more practical, are It is almost 180 years since James Parkinson more prone to bias. Particularly problematic is described his series of patients with what is the recruitment of control subjects and the now known as Parkinson's disease. His own measurement of putative exposures. Associa- astute clinical observations were unable to dis- tions must be treated with some caution and if cern any obvious aetiology. "On the subject possible verified using either historical data or a indeed of remote causes, no satisfactory cohort design. account has yet been obtained from any of the sufferers."' He noted an indulgence in alcohol, CASE DEFINITION lying on damp ground, and the possibility of The case definition for Parkinson's disease is trauma.