DOCSLIB.ORG

The Memoirs of Désiré Collen

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The Memoirs of Désiré Collen The memoirs of Désiré Collen The memoirs of Désiré Collen A HEART’S DESIRE BLENDING ACADEMIC RESEARCH AND BUSINESS ENTERPRISE Désiré Collen Translation into English from the Dutch original Memoires Désiré Collen Een hart voor onDerzoek en onDernemen © 2009 – Désiré Collen/Uitgeverij VanDen Broele, Brugge X + 228 p. Foto cover: Bart Van Leuven ISBN 978 90 4960 056 3 D/2009/0783/82 NUR 681 Vormgeving en Druk: Grafische groep VanDen Broele TekstreDactie: Peter Raeymaekers CONTENTS Preface .......................................................................................................................................... 1 t-PA and thrombolysis ... the context of a life's story ..................................................................... 7 A simple experiment .............................................................................................................................. 7 Lifesaving option against heart attack ................................................................................................... 7 Heart and vascular diseases - a heavy toll ............................................................................................. 8 Plaques and clots ................................................................................................................................... 9 "Open-Artery" hypothesis ................................................................................................................... 10 Cause or consequence? ....................................................................................................................... 11 Endurance of the stubborn .................................................................................................................. 11 Little enthusiasm ................................................................................................................................. 12 Renewed interest ................................................................................................................................ 13 Section I. The pre-history of the t-PA story .................................................................................... 15 Double qualifications .................................................................................................................... 17 First disciplined, then undisciplined and finally hard working ............................................................. 17 First research experience .................................................................................................................... 18 Medicine and chemistry ...................................................................................................................... 19 In the grip of research ................................................................................................................... 21 Clinical training hampered by revalidation and reorientation ............................................................ 22 New York ............................................................................................................................................. 24 Stockholm ............................................................................................................................................ 25 Back in Leuven ..................................................................................................................................... 26 Concluded ............................................................................................................................................ 27 Molecular mechanism of fibrinolysis elucidated ............................................................................ 31 Life and death of a blood clot .............................................................................................................. 31 The lytic trio: plasminogen activator, plasminogen and fibrin ............................................................ 32 An unknown inhibitor .......................................................................................................................... 34 Discovery of α2 antiplasmin ................................................................................................................ 36 Future entrepreneur? ................................................................................................................... 39 Under contract with LR&D ................................................................................................................... 39 Farmer-entrepreneur .......................................................................................................................... 40 V Section II. The t-PA story ............................................................................................................... 43 A difficult protein .......................................................................................................................... 45 Fibrin specific ....................................................................................................................................... 45 The rolling snowball ............................................................................................................................. 46 A drug against cancer? ........................................................................................................................ 46 Production champion .......................................................................................................................... 48 Run out of luck ..................................................................................................................................... 48 Assumptions become facts ............................................................................................................ 49 Rescuer from the Netherlands ............................................................................................................ 49 A short sprint ....................................................................................................................................... 50 A patent and a cont (r) act … with the alleged daughter of a professor .......................................... 55 Good advice from the Rector, Pieter De Somer .................................................................................. 55 A first patent ........................................................................................................................................ 55 Too early, too late … or just in time ..................................................................................................... 56 A piece of cake ..................................................................................................................................... 56 A new industry ..................................................................................................................................... 57 LR&D on a mission ............................................................................................................................... 58 18/24, 7/7 ............................................................................................................................................ 59 A beautiful protein ............................................................................................................................... 59 A headwind .................................................................................................................................. 61 Fat in the fire ....................................................................................................................................... 61 Loyalty in collaborations ...................................................................................................................... 61 Collaboration with Genentech continues ............................................................................................ 63 A first patient ................................................................................................................................ 65 Attending a Rotterdam conference ..................................................................................................... 65 A critically ill kidney transplant patient ............................................................................................... 65 Preclinical t-PA research ............................................................................................................... 69 American dogs ..................................................................................................................................... 69 Recombinant t-PA, indistinguishable from natural Bowes melanoma t-PA ........................................ 70 Taking no risks ..................................................................................................................................... 70 A lost friend ......................................................................................................................................... 71 The first clinical studies with t-PA ................................................................................................. 73 Double record ...................................................................................................................................... 73 First randomized study .......................................................................................................................
Load more

Recommended publications
  • Supplementary TABLE 1
    Note: This is Online Supplementary Document 1 of Koster W, Ndione AG, Adama M, et al. An oral history of medical laboratory development in francophone West African countries. Afr J Lab Med. 2021;10(1), a1157. https://doi.org/10.4102/ajlm.v10i1.1157 Supplementary TABLE 1: Physical places where literature was accessed [BR1] Country/city Place where documents were accessed Burkina Faso, Unité de Formation et de Recherche en sciences de la santé (UFR/SDS) de Ouagadougou l’université Ouaga 1 Professeur Joseph Ki Zerbo Centre National de Recherche Scientifique et Technologique (CNRST) Ecole National de Santé Publique (ENSP), Direction générale Union Monétaire des États de l’Afrique de l’Ouest (UEMOA) Institut de Recherche en Développement (IRD) Organisation mondiale de la Santé (OMS) au Burkina Faso Burkina Faso, Ecole National de Santé Publique (ENSP), Direction régionale Bobo Dioulasso Centre Muraz L’Organisation Ouest Africaine de la Santé (OAAS) Mali Institut National de Recherche en Santé Publique (INRSP) Bamako Bibliothèque nationale Archives nationales Centre National d’Appui à la lutte contre la Maladie (CNAM) ex-Institut Marchoux Faculté de Médecine et d’Odonto- Stomatologie et Faculté de Pharmacie Direction Nationale de la Santé (DNS) Direction de la Pharmacie et du Médicament (DPM) Pharmacie Populaire du Mali (PPM) Institut National de Formation en Sciences de la Santé (INFSS) Inspection de la santé Organisation mondiale de la Santé (OMS) à Bamako Senegal Bibliothèque universitaire de Dakar Dakar Assemblée Nationale du Sénégal Agence
    [Show full text]
  • Advanced Non-Small Cell Lung Cancer: Retrospective Study Of
    i e r Sc c nce e a c n an d C R f Journal of Cancer Science and e o s l e a a n r r c EL-Hadaad et al., J Can Sci Res 2017, 3:S1 h u o J Research DOI: 10.4172/2576-1447.1000S1-011 ISSN: 2576-1447 Research Article Open Access Advanced Non-Small Cell Lung Cancer: Retrospective Study of Prognostic Factors Hend A EL-Hadaad1*, Yasser M Saleh1, Hanan A Wahba1 and Magda A Ahmad2 1Department of Clinical Oncology& Nuclear Medicine, Mansoura University, Egypt 2Chest Medicine department, Mansoura University, Egypt *Corresponding author: Dr. Hend Ahmed El-Hadaad, MD, Faculty of medicine, University of Mansoura, Egypt, Tel: +20124272772; E-mail: [email protected] Received date: March 09, 2017; Accepted date: March 28, 2017; Published date: March 31, 2017 Copyright: © 2017 EL-Hadaad HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Objective: The objective of the study is to investigate and improve our understanding of the impact of several potential prognostic factors on overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC). Methods: Records of patients with advanced NSCLC (stage IIIB, IV) received first-line chemotherapy were reviewed. Age, gender, Eastern Cooperative Oncology Group performance status (ECOGPS), stage, histologic type, smoking status, leucocytic count, type of chemotherapy, albumin and hemoglobin level were evaluated for their prognostic significance in multivariate analysis.
    [Show full text]
  • Final Program
    1 General Information SCOPE OF THE CONFERENCE The 12th Joint MMM/Intermag Conference is sponsored jointly by the American Institute of Physics (through Physics Conferences Incorporated) and the Magnetics Society of IEEE. The Conference will be held at the Hyatt Regency Chicago in the heart of Chicago, Illinois, easily accessible from O'Hare and Midway Airports. Members of the international scientific and engineering communities interested in recent developments in funda- mental and applied magnetism are invited to attend the Conference and con- tribute to its technical sessions. Sessions will include invited and contributed papers in oral and poster sessions, invited symposia, a plenary session, and two evening sessions, one of which will be in a tutorial format. The Confer- ence provides an outstanding opportunity for participants to meet their col- leagues and discuss the latest advances in magnetism. Please note that all of the conference details, including web links for registration and hotel reser- vations, are available at the conference website: http://www.magnetism.org CHICAGO Few cities in the world can match the character and culture of Chicago. Here you can find world-class dining, museums and entertainment. Chicago is the largest and most visited city in the Midwest of the United States. The Chicago Convention & Tourism Bureau is dedicated to helping you enjoy your stay in Chicago. On its web site, http://www.choosechicago.com you can experience the city like a local by obtaining the latest information on Chicago attractions such as the Navy Pier and Millennium Park, as well as the numerous outstanding museums and galleries.
    [Show full text]
  • Medical Laboratory and Diagnosis Volume 7 Number 6 December 2016 ISSN 2141-2618
    Journal of Medical Laboratory and Diagnosis Volume 7 Number 6 December 2016 ISSN 2141-2618 ABOUT JMLD Journal of Medical Laboratory and Diagnosis (JMLD) is published monthly (one volume per year) by Academic Journals. Journal of Medical Laboratory and Diagnosis (JMLD) provides rapid publication (monthly) of articles in all areas of the subject such as Parasitism, Helminthology, Cloning vector, retroviral integration, Genetic markers etc. Contact Us Editorial Office: [email protected] Help Desk: [email protected] Website: http://www.academicjournals.org/journal/JMLD Submit manuscript online http://ms.academicjournals.me/ Editors Dr. Ratna Chakrabarti Dr. Rokkam Madhavi Department of Molecular Biology and Microbiology, Andhra University University of Central Florida, Visakhapatnam - 530003 Biomolecular Research Annex, Andhra Pradesh 12722 Research Parkway, India. Orlando, USA. Dr. Mukabana Wolfgang Richard School of Biological Sciences Dr. Rajni Kant University of Nairobi Scientist D (ADG), P.O. Box 30197 - 00100 GPO (P&I Division)Indian Council of Medical Research Nairobi, Post Box 4911, Ansari Nagar, Kenya. New Delhi-110029 India. Dr. Lachhman Das Singla College of Veterinary Science Dr. Ramasamy Harikrishnan Guru Angad Dev Veterinary and Animal Sciences Faculty of Marine Science, College of Ocean University Sciences Ludhiana-141004 Jeju National University Punjab Jeju city, Jeju 690 756 India. South Korea. Editorial Board Dr. Imna Issa Malele Dr. James Culvin Morris Tsetse & Trypanosomiasis Research Institute Clemson
    [Show full text]
  • Madridge Journal of Immunology
    ISSN: 2638-2024 Madridge Journal of Immunology Research Article Open Access Counterproductive contributions to African Epidemiology Helen Lauer1* and Joan Shenton2 1Professor, University of Dar es Salaam, Tanzania 2Director, Meditel Productions, UK Article Info Abstract *Corresponding author: Throughout this retrospective, our purpose is to illuminate an evident knowledge Helen Lauer handicap, cutting across the diagnostic procedures, reportage and mathematical Professor University of Dar es Salaam modelling of chronic illness affecting African public health demographics, which we Dar es Salaam trace to three epistemic injustices (methodological, documental, and professional) in Tanzania the way medical research in Africa is managed and monitored by foreigners. We E-mail: [email protected] propose that the mutual reinforcement of these three different kinds of epistemic transgression underlies the chronic failure of immunologists and public health Received: November 14, 2017 Accepted: November 17, 2017 practitioners to subdue the inflated rates of morbidity and short life expectancy Published: November 24, 2017 persistent throughout Africa. Substandard data collection and implausible infection modelling count as injustices because they are traceable to a routine disregard for best Citation: Lauer H, Shenton J. Counterproductive scientific practice at the upper echelons of global health authority, which is betrayed Madridge contributions to African Epidemiology. by an inordinately high tolerance for diagnostic error concerning populations
    [Show full text]
  • Parathormone Determination in the Clinical Laboratory: Biochemical, Analytical and Clinical Aspects
    UNIVERSITY OF LIEGE FACULTY OF MEDICINE DEPARTMENT OF CLINICAL CHEMISTRY Professor J.P. Chapelle PARATHORMONE DETERMINATION IN THE CLINICAL LABORATORY: BIOCHEMICAL, ANALYTICAL AND CLINICAL ASPECTS. Thesis submitted by Etienne CAVALIER for the degree of « Docteur en Sciences Biomédicales et Pharmaceutiques » Academic year 2009-2010 UNIVERSITY OF LIEGE FACULTY OF MEDICINE DEPARTMENT OF CLINICAL CHEMISTRY Professor J.P. Chapelle PARATHORMONE DETERMINATION IN THE CLINICAL LABORATORY: BIOCHEMICAL, ANALYTICAL AND CLINICAL ASPECTS. Thesis submitted by Etienne CAVALIER for the degree of « Docteur en Sciences Biomédicales et Pharmaceutiques » Academic year 2009-2010 1 University of Liege – Faculty of Medicine Department of Clinical Chemistry. Parathormone determination in the Clinical Laboratory: biochemical, analytical and clinical aspects. Abstract. The aim of our work was to provide comprehensive data to the study of the Parathyroid hormone (Parathormone, or PTH). The first part of the manuscript concerns the “laboratory” aspects of PTH determination. We thus studied the stability of the peptide when stored at different temperatures (pre-analytical phase). From an analytical point of view, we compared different methods for PTH determination and the impact of any change in PTH determination for the follow-up of the hemodialyzed patients. We also studied some analytical interferences and provided a validation strategy that takes into consideration these interferences. Finally, for the post-analytical phase, we established the reference range of PTH with two different methods. We provided guidelines which could help laboratories to establish their own reference range for PTH and studied the clinical impact of applying this newly established reference range in the daily routine. The second part of the manuscript is more dedicated to the “clinical” aspects of PTH determination.
    [Show full text]
  • Andreas Vesalius' Corpses
    Izvorni znanstveni ~lanak Acta med-hist Adriat 2014; 12(1);9-26 Original scientific paper UDK: 61:616.091’’16’’(091) ANDREAS VESALIUS’ CORPSES KADAVERI ANDRIJE VEZALA Maurits Biesbrouck*, Omer Steeno** Summary Judging from his writings, Andreas Vesalius must have had dozens of bodies at his disposal, thirteen of which were definitely from before 1543. They came from cemeteries, places of exe- cution or hospitals. Not only did his students help him obtain the bodies, but also public and judicial authorities. At first, he used the corpses for his own learning purposes, and later to teach his students and to write De humani corporis fabrica, his principal work. Clearly he had an eye for comparative anatomy. He observed anatomical variants and studied foetal anatomy. Occasionally, he would dissect a body to study physiological processes, while the post-mortems on the bodies brought in by the families of the deceased gave him an insight into human pathology. Some of his dissection reports have been preserved. Key words: History of medicine; 16th century; anatomy; pathology; corpses; Andreas Vesalius; Fabrica. To become the founder of modern anatomy, Andreas Vesalius (Brussels, 31 December 1514 - Zakynthos, 15 October 1564) must have had access to a large quantity of human remains in the broadest sense of the term. These constituted his source of data and his study material. At first, he used these remains to learn, and, when his knowledge reached an unprecedented level, * Former clinical biologist at the City Hospital in Roeselare, Belgium. ** Professor emeritus at the Faculty of Medicine of the Catholic University of Leuven (Louvain), Belgium.
    [Show full text]
  • ESRR16 Final Programme 1.Pdf
    Downloaded from orbit.dtu.dk on: Oct 05, 2021 Development of an experimental method using Cs-131 to evaluate radiobiological effects of internalized Auger-electron emitters. Fredericia, Pil; Severin, Gregory; Groesser, Torsten; Köster, Ulli; Jensen, Mikael Published in: 18th European Symposium on Radiopharmacy and Radiopharmaceuticals Publication date: 2016 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Fredericia, P., Severin, G., Groesser, T., Köster, U., & Jensen, M. (2016). Development of an experimental method using Cs-131 to evaluate radiobiological effects of internalized Auger-electron emitters. In 18th European Symposium on Radiopharmacy and Radiopharmaceuticals: Final programme (pp. 114-114). [PP52] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. 18th European Symposium on Radiopharmacy and Radiopharmaceuticals FINAL PROGRAMME April 07-10, 2016 Salzburg, Austria 18th European Symposium on Radiopharmacy and Radiopharmaceuticals April 07-10, 2016 Salzburg, Austria TABLE OF CONTENTS Welcome Address .....................................................................................................................................
    [Show full text]
  • Addressing Amr in Madagascar: the Experience of Establishing a Medical Bacteriology Laboratory at the Befelatanana University Hospital in Antananarivo
    IPC AND SURVEILLANCE ADDRESSING AMR IN MADAGASCAR: THE EXPERIENCE OF ESTABLISHING A MEDICAL BACTERIOLOGY LABORATORY AT THE BEFELATANANA UNIVERSITY HOSPITAL IN ANTANANARIVO DR SAÏDA RASOANANDRASANA (TOP LEFT), HEAD OF MICROBIOLOGY, BEFELATANANA UNIVERSITY HOSPITAL LABORATORY, MADAGASCAR; DR LALAINA RAHAJAMANANA (TOP MIDDLE-LEFT), HEAD, BACTERIOLOGY LABORATORY, TSARALALÀNA MOTHER-CHILD UNIVERSITY HOSPITAL, MADAGASCAR; DR CAMILLE BOUSSIOUX (TOP MIDDLE-RIGHT), HOSPITAL RESIDENT, MÉRIEUX FOUNDATION; DR MARION DUDEZ (TOP RIGHT), MEDICAL BIOLOGIST, FORMER RESIDENT, THE MÉRIEUX FOUNDATION IN MADAGASCAR; DR ODILE OUWE MISSI OUKEM-BOYER (BOTTOM LEFT), MÉRIEUX FOUNDATION MALI AND NIGER COUNTRY MANAGER, ACTING DIRECTOR GENERAL, CHARLES MÉRIEUX CENTER FOR INFECTIOUS DISEASE IN MALI; LUCIANA RAKOTOARISOA (BOTTOM MIDDLE-LEFT), MÉRIEUX FOUNDATION MADAGASCAR COUNTRY MANAGER; DR LAURENT RASKINE (BOTTOM MIDDLE-RIGHT), HEAD, SPECIALIZED BIOLOGY, MÉRIEUX FOUNDATION AND DR FRANÇOIS-XAVIER BABIN (BOTTOM RIGHT), DIRECTOR, DIAGNOSTICS AND HEALTH SYSTEMS, MÉRIEUX FOUNDATION In 2016, the Mérieux Foundation launched a project with the Ministry of Public Health to create a bacteriology laboratory at Befelatanana hospital in Antananarivo (Madagascar). The objective was to create and ensure the continued viability of operations for an essential package of analyses, to improve diagnosis and produce reliable data on antimicrobial resistance. The laboratory results have improved patient care and enabled antibiotic stewardship and hospital acquired infection control. Preliminary
    [Show full text]
  • Using Remote Labs.Indd
    Javier García Zubía and Gustavo R. Alves (eds.) Using Remote Labs in Education Two Little Ducks in Remote Experimentation Prize for Best Research UD – Grupo Santander DeustoDigital Using Remote Labs in Education Two Little Ducks in Remote Experimentation © University of Deusto - ISBN 978-84-9830-398-8 Using Remote Labs in Education Two Little Ducks in Remote Experimentation Javier García Zubía and Gustavo R. Alves (eds.) Juan Vélez S.J. Diego Gracia Carlos M.ª Romeo Javier Gafo S.J. Marciano Vidal José C. Bermejo 2011 University of Deusto Bilbao © University of Deusto - ISBN 978-84-9830-398-8 Engineering, no. 8 Edition revised by Anselmo del Moral Bueno Any form of reproduction, distribution, public communi- cation or transformation of the work can only be performed following authorisation by its owners, unless legally es- tablished otherwise. If you wish to photocopy or scan any part of this work please contact CEDRO (Centro Español de Derechos Reprográfi cos / Spanish Copyrights Centre) at www.cedro.org. © University of Deusto P.O. box 1 - 48080 Bilbao e-mail: [email protected] ISBN: 978-84-9830-398-8 Legal Deposit: BI - 3.409-2011 Impreso en España/Printed in Spain © University of Deusto - ISBN 978-84-9830-398-8 Contents Preface, Susan M. Zvacek . 11 Introduction, Javier García Zubía, Gustavo R. Alves . 17 SECTION 1 Pioneers Chapter 1. Second Best to Being There: An Historical Perspective, Molly H. Shor, Carisa Bohus, Burçin Atkan . 27 Chapter 2. Engineering Controls Labs Operated Remotely, Jim Henry, Murat Ozkaya . 53 SECTION 2 iLabs around the Globe Chapter 3.
    [Show full text]
  • Clinical Laboratory Improvement Advisory Committee
    Clinical Laboratory Improvement Advisory Committee Meeting Transcript April 10-11, 2019 Baltimore, Maryland U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES 1 April 10, 2019 Call to Order and Committee Member Introductions CLIAC CHAIR: Well everybody, I'll ask committee members to take your seats as we prepare to begin the meeting. Do we have quorum? I think we have quorum. CLIAC DFO: Good morning, and welcome to CLIAC. I'd like to take this opportunity to thank our hosts at CMS. This is a great opportunity. It's the first time in CLIAC's history that we have held this meeting at CMS. So it's a great opportunity for us. We begin with introductions and conflicts of interest. And we'd like for each CLIAC member, beginning with Campbell, to introduce themselves, provide just their affiliation, as well as their indication of any conflicts of interest. And we'll go around the table. So we'll take care of introductions and conflicts of interest at the same time. CLIAC MEMBER: I'm Sheldon Campbell from Yale School of Medicine and VA Connecticut Healthcare. I'm on College of American Pathologists Checklists Committee, the Lab Practices Committee of the American Society for Microbiology, and no other conflicts of interest. CLIAC MEMBER: I'm Marc Couturier from University of Utah, ARUP Laboratories. I am also on the Clinical Laboratory Practices Committee through the American Society for Microbiology. I have a financial conflict of interest with BioFire Diagnostics, for which my spouse draws a household income. And I have a conflict of interest for research reagents with Apacor Limited, Meridian Biosciences, and DSORG.
    [Show full text]
  • Educational Workshop EW11: Development of Molecular Assays: Do's & Don't's Arranged with the ESCMID Study Group for Molecular Diagnostics (ESGMD)
    Educational Workshop EW11: Development of molecular assays: do's & don't's arranged with the ESCMID Study Group for Molecular Diagnostics (ESGMD) Convenors: Marijjyke Raymaekers ( Hasselt,,) BE) Paul Savelkoul (Amsterdam, NL) Faculty: Anton M. van Loon (Utrecht, NL) Kate Templeton (Edinburgh, UK) Marijke Raymaekers (Hasselt, BE) Udo Reischl (Regensburg, DE) Paul Savelkoul (Amsterdam, NL) Van Loon - QC controls Development of Molecular Assays: Do’s and Don’t’s QC controls Anton M van Loon Department of Virology, University Medical Centre Utrecht, the Netherlands QCMD, Glasgow Scotland 1 Anton M van Loon, ECCMID 2010 Molecular Diagnostics is hot! Scientific impact •The human genome project •Elucidation of new pathogenesis pathways •Discovery of new infectious agents Increased public awareness •Criminal investigations and court room cases (Castro –Ponce, Nienke K, etc.) • Fuelled by Film and TV industry (CSI, ‘Waking the Dead’, 6th Day, etc.) 2 Anton M van Loon, ECCMID 2010 DNA tells the truth General perception: DNA doesn’t lie –or does it? •Famous court cases, for example Castro –Ponce •Incorrect results on BCRA‐1/2 detection • Missed HIV diagnosis in neonate • Conflicting reports in literature, for instance on the etiology of chronic fatigue syndrome, ALS, schizophrenia, etc. So, maybe DNA does not lie, but it still requires human efforts to develop assays, to collect and investigate samples, and to interpret the results: need to monitor quality of the overall process! 3 Anton M van Loon, ECCMID 2010 3 Van Loon - QC controls Quality Concerns
    [Show full text]