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Belgian Ebola Guidelines

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Belgian Ebola Guidelines PUBLICATION OF THE SUPERIOR HEALTH COUNCIL No. 9188 Practical recommendations to the attention of healthcare professionals and health authorities regarding the identification of and care delivered to suspected or confirmed carriers of highly contagious viruses (of the Ebola or Marburg type) in the context of an epidemic outbreak in West Africa Recommandations pratiques concernant l’identification et la prise en charge de patients suspectés ou avérés être porteurs de virus hautement contagieux (de type Ebola ou Marburg) dans le cadre d’une bouffée épidémique en Afrique de l’Ouest, à l’attention des professionnels de la santé et des autorités sanitaires. Praktische aanbevelingen ter attentie van gezondheidswerkers en gezondheidsautoriteiten betreffende de identificatie en het beheer van vermoede of bevestigde dragers van zeer besmettelijke virussen (van het Ebola- of Marburg-type) in het kader van een uitbraak in West-Afrika. 4 July 2014 SUMMARY This document provides guidance on the management of patients in whom an infection with Ebola or Marburg disease (EMD) is considered, suspected or confirmed. This guidance aims to eliminate or minimize the risk of transmission to healthcare workers and others coming into contact with an infected patient or their samples. VHFs (Viral haemorrhagic fever) are severe and life-threatening viral diseases that have been reported in parts of Africa. VHFs are of particular public health importance because they can spread within a hospital setting; they have a high case-fatality rate; they are difficult to recognize and detect rapidly; and there is no effective treatment. Evidence from outbreaks strongly indicates that the main routes of transmission of EMD infection are direct contact (through broken skin or mucous membrane) with blood or body fluids, and indirect contact with environments contaminated with splashes or droplets of blood or body fluids. Experts agree that there is no circumstantial or epidemiological evidence of an aerosol transmission risk from VHF patients. This guidance recommends control options for the isolation of EMD patients in Belgium. Scientific support to the team delivering care to the patient will be provided by the "task group on travel-related diseases", which includes infectiologists with a broad experience on imported infections and who are affiliated with different Belgian academic institutions (see appendix 2). KEYWORDS Ebola disease, carrier, identification, care, Belgium. − 1 − Superior Health Council Place Victor Horta 40/10 ● 1060 Brussels ● www.shc-belgium.be CONTENTS 1. INTRODUCTION AND ISSUES ............................................................................................. 4 2. FURTHER DETAILS AND ARGUMENTATION .................................................................... 5 3. RECOMMENDATIONS ......................................................................................................... 6 Section 1 : Introduction .......................................................................................................... 6 Section 2 : Patient assessment algorithm ............................................................................. 7 Section 3 : Management of a patient categorized as ‘possible case of EMB’ ................... 10 Section 4 : Management of a patient categorized as ‘High possibility of EMB’ ................ 13 Section 5 : Management of a patient with a positive EMD screen ..................................... 15 4. REFERENCES .................................................................................................................... 16 5. APPENDICES ..................................................................................................................... 16 APPENDIX 1 : Overview of ACDP Hazard Group 4 VHFs APPENDIX 2 : Contact details APPENDIX 3 : General principles for the isolation of patients with a high possibility or confirmed EMD in the present situation in Belgium APPENDIX 4 : Transfer of a patient APPENDIX 5 : Specimen collection and handling APPENDIX 6 : Laboratory procedures APPENDIX 7 : Personal Protective Equipment (including Respiratory Protective Equipment) APPENDIX 8 : Management of staff accidentally exposed to potentially infectious material APPENDIX 9 : Decontamination, including treatment of laundry APPENDIX 10 : Waste treatment and disposal APPENDIX 11 : After death care APPENDIX 12 : Principles for the ideal organization of a HSIDU 6. COMPOSITION OF THE WORKING GROUP ..................................................................... 51 − 2 − Superior Health Council Place Victor Horta 40/10 ● 1060 Brussels ● www.shc-belgium.be ABBREVIATIONS AND SYMBOLS ACDP Advisory Committee on Dangerous Pathogens BNI Bernard Nocht Institute ECDC European Centre for Disease Prevention and Control EMD Ebola or Marburg disease EN European standard EUNID European Network of Infectious Diseases FFP3 Filtering facepiece type 3 (filtering efficiency of 99%) HEPA High efficiency particulate air HSIDU High security infectious disease unit IATA International Air Transport Association ICU Intensive care unit IDU Infectious disease unit ITM Institute of Tropical Medicine (ITG-IMT) NaDCC Sodium dichloroisocyanurate NaOCl Sodium hypochlorite PCR Polymerase chain reaction ppm parts per million PPE Personal protective equipment PPE Personal protective equipment PROMED Program for Monitoring Emerging Diseases RPE Respiratory protective equipment SHC Superior Health Council (Conseil Supérieur de la Santé - Hoge Gezondheidraad) VHF Viral haemorrhagic fever UK United Kingdom UZA Universitaire Ziekenhuis Antwerpen WEL Workplace exposure limit WHO World Health Organization − 3 − Superior Health Council Place Victor Horta 40/10 ● 1060 Brussels ● www.shc-belgium.be 1. INTRODUCTION AND ISSUES Given current events in West Africa regarding the resurgence of the Ebola virus and the extremely rapid increase in the number of victims, people travelling away from the affected areas pose a risk to public health in the destination countries. The Chairs of the SHC sub-areas of "Infection control during care" and "Vaccination" have therefore highlighted the need to draw up practical recommendations for the medical profession without delay. These recommendations will address the actions to be taken when dealing with a suspected case, how to manage the latter, as well as the specialized care to provide to confirmed cases. The epidemic potential of the current Ebola virus may be different from what it was in the past. It is the reaction of the local West-African population concerned that in itself causes a real management problem (see editorial of The Lancet, 7 June 2014). Suspected cases in less well-equipped local general healthcare facilities should be referred to a nearby tertiary hospital. Ideally, microbiologically confirmed cases should be treated in an institution with a specialized high security infectious disease unit (HSIDU), as described by the experts of the "European Network of Infectious Diseases" (EUNID, 2009). A proven case (that was confirmed abroad) should be referred to the operational sites that are already in place (such as London, Rome, Hamburg, ...). Before implementing these applications in actual practice, it is essential that the competent health authorities concerned set up a cooperation agreement with the tertiary care institutions (university hospitals) in question. − 4 − Superior Health Council Place Victor Horta 40/10 ● 1060 Brussels ● www.shc-belgium.be 2. FURTHER DETAILS AND ARGUMENTATION To respond to the need for recommendations within a tight deadline, an “ad hoc” working group was set up with experts on infectiology, medical microbiology, travel-related diseases, tropical diseases, vaccination and infection control during care (hospital hygiene). These recommendations are a Belgian adaptation of the « Management of Hazard Group 4 viral haemorrhagic fevers and similar human infectious diseases of high consequence » (2012) that was prepared by the UK Advisory Committee on Dangerous Pathogens (ACDP), in conjunction with the Health and Safety Executive, with special thanks to the Health and Safety Laboratory; the Department of Health; the Devolved Administrations; and the National Health Service. In particular, the SHC would like to draw the reader's attention to the fact that these recommendations are substantially based on this extensive and recent work and have been adapted to fit with the Belgian contingencies. This document does not address the global issue of haemorrhagic fevers, but only focusses on Marburg and Ebola fever. An improved version of this document must be provided before the end of 2014. The full version of the original document (from Great Britain) is available at the following address http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1194947382005 . These recommendations specify on page 2 that « You may re-use the text of this document (not including logos) free of charge in any format or medium, under the terms of the Open Government Licence. To view this licence, visit www.nationalarchives.gov.uk/doc/open- government-licence/ ». − 5 − Superior Health Council Place Victor Horta 40/10 ● 1060 Brussels ● www.shc-belgium.be 3. RECOMMENDATIONS Section 1 : Introduction 1. This document provides guidance on the management of patients in whom an infection with the Ebola or Marburg viruses is considered, suspected or confirmed. 2. This guidance aims to eliminate or minimize the risk of transmission to healthcare and other workers coming into contact with an infected
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