Molecular Psychiatry (2013) 18, 523 & 2013 Macmillan Publishers Limited All rights reserved 1359-4184/13 www..com/mp

IMAGE Reproduced from volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study

JB Savitz1,2, SL Rauch3,4 and WC Drevets1,5

Third Ventricle Medial Dorsal Limitans / Habenula

Posterior Commissure Habenula

Cerebral Aqueduct

Molecular Psychiatry (2013) 18, 523; doi:10.1038/mp.2013.43

High-resolution coronal MRI sections (E0.4 mm3) showing the habenula and the local anatomical landmarks, which enabled its segmentation. Because the contain relatively dense plexuses, they can be collectively delimited from the gray matter of the adjacent thalamus dorsolaterally and the limitans nucleus and pretectal area ventrolaterally. In posterior planes, the habenula is clearly evident as a pyramidal-shaped structure that bulges into the along the ventromedial aspect of the thalamus, whereas in anterior planes it can be delimited ventrally and medially from the thalamus by the stria medullaris of thalamus. Finally, the habenular nuclei are delimited ventrally by the white matter of the . The upper and lower panels consist of the identical image. The tracing of the habenula is shown in yellow in the lower panel. For more information on this topic, please refer to the article by Savitz et al. on pages 528–539.

1Laureate Institute for Research, Tulsa, OK, USA; 2Department of Medicine, Tulsa School of Community Medicine at the University of Tulsa, Tulsa, OK, USA; 3McLean Hospital, Belmont, MA, USA; 4Department of Psychiatry, Harvard Medical School, Boston, MA, USA and 5Johnson and Johnson Pharmaceuticals Research and Development, Titusville, NJ, USA