Novel

LC-MS/MS Kit System for Therapeutic Drug Monitoring ClinMass® TDM Kit System Therapeutic Drug Monitoring (TDM) by LC-MS/MS

The ClinMass® TDM Kit System is based on a universal TDM Plat- Benefits of the ClinMass® TDM Kit System form (order no. MS9000). It allows to enlarge the spectrum of analytical parameters by simple combination of the ClinMass® • Determination of currently 131 different analytes using TDM Platform with any ClinMass® Add-on Set. Select your ana- - one TDM Platform1 lyte panel by choosing the suitable ClinMass® Add-on Sets! - one analytical column • Simple one-step sample preparation for a quick sample processing 1i.e. identical sample preparation and mobile phases

Currently available ClinMass® Add-on Sets

35 Benzodiazepines (BZP) 15 Tricyclic Antidepressants (TCA) 26 Antiepileptic Drugs (AED) 27 Antidepressants (ADP) 28 Neuroleptics (NLP)

Additional Add-on Sets in preparation: Antimycotics (AMC), Cytostatics (CYT)

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One step sample preparation!

Analyte survey of the currently available ClinMass® Add-on Sets

Add-on Set for Add-on Set for Add-on Set for Add-on Set for Add-on Set for 35 Benzo- 15 Tricyclic 26 Antiepileptic 27 Anti- 28 Neuroleptics diazepines Antidepressants Drugs depressants

Order no. MS9500 Order no. MS9100 Order no. MS9200 Order no. MS9400 Order no. MS9300

Alprazolam* Amitriptyline* Carbamazepine* Atomoxetine* Amisulpride* Alprazolam, α-Hydroxy-* Clomipramine* Carbamazepine, 10-OH- Bupropion* Aripiprazole* Bromazepam Clozapine* Carbamazepine-diol Bupropion, erythro-Dihydro- Aripiprazole, Dehydro-* Bromazepam, 3-Hydroxy- Desipramine* Carbamazepine-epoxide Bupropion, Hydroxy- Chlorpromazine* Chlordiazepoxide* Doxepin* N-Desmethylmethsuximide Bupropion, threo-Dihydro-* Chlorprothixene* Clobazam Imipramine* Ethosuximide* Citalopram* Clozapine* Clonazepam* Maprotiline* Felbamate* Clomethiazole Flupentixol* Clonazepam, 7-Amino-* Norclomipramine* Gabapentine Dosulepin* Fluphenazine* Demoxepam Norclozapine* Lacosamide* Duloxetine* Haloperidol* Diazepam* Nordoxepin* Lamotrigine* Fluoxetine* Levomepromazine* Estazolam* Normaprotiline Levetiracetam* Fluoxetine, Desmethyl-* Melperone* Flunitrazepam* Nortrimipramine Oxcarbazepine* Fluvoxamine* Norclozapine* Flunitrazepam, 7-Amino-* Nortriptyline* PEMA* Mianserine* Norquetiapine Flunitrazepam, Desmethyl- Protriptyline Perampanel Milnacipran* Olanzapine* Flurazepam Trimipramine* Phenobarbital* Mirtazapine* Olanzapine, Desmethyl- Flurazepam, Desalkyl- Phenytoin Mirtazapine, Desmethyl- Paliperidone (9-OH-Risperidone)* Lorazepam* Pregabaline* Moclobemide* Perazine* Lormetazepam Primidone* Opipramol* Pipamperone* Medazepam Retigabine* Paroxetine* Promethazine* Midazolam* Rufinamide Reboxetine* Prothipendyl* Midazolam, α-Hydroxy-* Stiripentol* Ritalinic Acid Quetiapine* Nitrazepam* Sulthiame Sertraline* Risperidone* Nitrazepam, 7-Amino- Tiagabine* Sertraline, Desmethyl-* Sertindole* Norclobazam Topiramate* Tranylcypromine* Sulpiride* Nordiazepam* Valproic Acid* Trazodone Thioridazine* Oxazepam* Zonisamide* Venlafaxine* Ziprasidone* Prazepam* Venlafaxine, O-Desmethyl- Zotepine Temazepam* Zuclopenthixol* Tetrazepam Trazodone Triazolam* Triazolam, α-Hydroxy-* Zaleplon Zolpidem* Zopiclone

*Internal standard contains stable isotope-labelled substance

One step sample Antiepileptic Drugs (AED) preparation! LC Parameters Binary HPLC pump: Mobile Phase A/B (0.6 ml/min) Injection volume: 1 - 10 µl Injection interval: 4.5 min Column heater: 40 °C Chromatogram ClinCal® Serum Calibrator, Level 2 (order no. MS9213)

8.0 Pregabaline 0.86 Lamotrigine 2.16 7.2 Gabapentin 0.87 10-OH-Carbamazepine 2.29 6.4 Levetiracetam 0.93 Phenobarbital 2.39 5.6 Phenylethylmalonamide N-Desmethylmethsuximide 4.8 (PEMA) 1.17 (NDMS) 2.62 Ethosuximide 1.29 Carbamazepine-Epoxide 2.70 * Reconstitution of IS 4.0 MS Parameters Primidone 1.60 Oxcarbazepine 2.98 with Precipitant P 3.2 Valproic acid 1.68 Topiramate 3.04 2.4 Sultiame 1.70 Carbamazepine 3.36 Ion source: Electrospray Ionisation (ESI) 1.6 Lacosamide 1.80 Phenytoin 3.37 0.8 Zonisamide 1.83 Tiagabine 3.41 0.0 Felbamate 2.03 Retigabine 3.63 MS/MS mode: MRM Carbamazepine-Diol 2.08 Perampanel 3.94 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.4 Rufinamide 2.13 Stiripentol 4.07

Benzodiazepines (BZP) Antidepressants (ADP) LC Parameters LC Parameters Binary HPLC pump: Mobile Phase A/B (0.6 ml/min) Binary HPLC pump: Mobile Phase A/B (0.7 ml/min) Injection volume: 1 - 10 µl Injection volume: 1 - 10 µl Injection interval: 6.8 min Injection interval: 3.5 min Column heater: 40 °C Column heater: 40 °C Chromatogram Chromatogram ClinCal® Serum Calibrator, Level 2 (order no. MS6013) ClinCal® Serum Calibrator, Level 2 (order no. MS9413)

        3.8e6     3.4e6 Ritalinic acid 0.76 Opipramol 1.68      Tranylcypromine 0.89 Paroxetine 1.69 3.0e6 O-Desmethylvenlafaxine 0.92 Mirtazapine 1.70          2.6e6 Moclobemide 1.13 Fluvoxamine 1.78      2.2e6 Desmethylmirtazapine 1.15 Trazodone 1.78      Milnacipran 1.15 Duloxetine 1.81  1.8e6      (cps) intensity OH-Bupropion 1.21 Desmethylfluoxetine 1.83     1.4e6 Venlafaxine 1.27 Bupropion 1.88      erythro-Dihydro-Bupropion Dosulepin 1.96  1.0e6     threo-Dihydro-Bupropion 1.28* Fluoxetine 1.96  6.0e5      Clomethiazole 1.33 Norsertraline 2.10     2.0e5 Citalopram 1.55 Sertraline 2.30 0.0      Reboxetine 1.58 Mianserin 2.51                 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 Atomoxetine 1.67       

Tricyclic Antidepressants (TCA) Neuroleptics (NLP) LC Parameters LC Parameters Binary HPLC pump: Mobile Phase A/B (0.8 ml/min) Binary HPLC pump: Mobile Phase A/B (0.65 ml/min) Injection volume: 1 - 10 µl Injection volume: 1 - 10 µl Injection interval: 3.8 min Injection interval: 5.5 min Column heater: 40 °C Column heater: 40 °C

Chromatogram     Chromatogram    ClinCal® Serum Calibrator, Level 2 (order no. MS9113)  ClinCal® Serum Calibrator, Level 2 (order no. MS9313)                   

                                                                    intensity (cps) intensity intensity (cps) intensity                  

                                                             

    Ordering Information TDM Platform Order No. Description Quantity

MS9000 ClinMass® TDM Platform 1 pce. for 400 assays

Content (order no. MS9000)

MS9005 Autosampler Washing Solution 1000 ml

MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml)

MS9008 Mobile Phase B 1000 ml

MS9020 Sample Preparation Vials 4 x MS9020 (4 x 100 pcs.)

MS9021 Precipitant P 2 x MS9021 (2 x 25 ml)

Start Accessories

MS9030 Analytical Column with test chromatogram 1 pce.

MS9032 Prefilter 1 pce.

Accessories

MS9022 Diluting Solution D 50 ml

Add-On Sets The ClinMass® Add-on Sets contain all analyte specific com- ponents required: Optimisation Mixes, Internal Standards IS, Serum Calibrator Set, Serum Control Set and User Manual

Order No. Description Quantity

MS9100 ClinMass® Add-on Set for Tricyclic Antidepressants in Serum / Plasma 1 pce. for 200 assays

MS9200 ClinMass® Add-on Set for Antiepileptic Drugs in Serum / Plasma 1 pce. for 200 assays

MS9300 ClinMass® Add-on Set for Neuroleptics in Serum / Plasma 1 pce. for 200 assays

MS9400 ClinMass® Add-on Set for Antidepressants in Serum / Plasma 1 pce. for 200 assays

MS9500 ClinMass® Add-on Set for Benzodiazepines in Serum / Plasma 1 pce for 200 assays

The ClinMass® TDM Kit System is additionally available for on-line SPE analysis (ClinMass® “TDM Kit System, on-line”). V1 - 02/2017

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