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Venn Diagram Lists Supplementary Table SIV: Infection with different strains of T. cruzi results in the differences in the transcriptional response at the site of infection. Genes found to be significantly upregulated (FDR<.05 and Fold change >2) in Y strain,Brazil strain or G strain infected skin as compared to mock infected skin were determined. Duplicate genes and genes without descriptions were removed from analysis and gene lists from each strain were compared. Comparisons of gene lists were used to create a venn diagram (Fig. 5A) and the the list of gene descriptions belonging to the following interesections are listed: (A) Intersection of Y, Brazil and G strains, (B) Intersection of Y and G strains only, (C) intersection of Y and Brazil strains only, no genes fell into the intersection of G and Brazil strains only, (D) unique to Y strain, (E) Unique to Brazil strain, (F) Unique to G strain. A Intersection Y, Brazil and G strains Description 2'-5' oligoadenylate synthetase 1A 2'-5' oligoadenylate synthetase 2 2'-5' oligoadenylate synthetase-like 2 apolipoprotein L 9b CD274 antigen CDNA clone IMAGE:30303372 cDNA sequence BC006779 cDNA sequence BC023105 chemokine (C-X-C motif) ligand 10 chemokine (C-X-C motif) ligand 11 chemokine (C-X-C motif) ligand 9 cytidine monophosphate kinase 2, mitochondrial DEAD box polypeptide 58 deltex 3-like DEXH box polypeptide 58 DNA segment, Chr 14, ERATO Doi 668, expressed epithelial stromal interaction 1 expressed sequence AI451617 expressed sequence AW112010 Fc receptor, IgG, low affinity IV GTPase, very large interferon inducible 1 guanylate binding protein 6 guanylate nucleotide binding protein 1 guanylate nucleotide binding protein 2 guanylate nucleotide binding protein 3 hect domain and RLD 5 histocompatibility 28 hypothetical protein 9530028C05 immunity-related GTPase family, M interferon activated gene 203 interferon gamma induced GTPase interferon gamma inducible protein 47 interferon induced with helicase C domain 1 interferon inducible GTPase 1 interferon inducible GTPase 2 interferon regulatory factor 7 interferon-induced protein 44 interferon-induced protein with tetratricopeptide repeats 1 interferon-induced protein with tetratricopeptide repeats 2 interferon-induced protein with tetratricopeptide repeats 3 interferon-stimulated protein interleukin 18 binding protein ISG15 ubiquitin-like modifier macrophage activation 2 like myxovirus (influenza virus) resistance 1 myxovirus (influenza virus) resistance 2 nuclear antigen Sp100 poly (ADP-ribose) polymerase family, member 12 poly (ADP-ribose) polymerase family, member 14 poly (ADP-ribose) polymerase family, member 9 predicted gene, OTTMUSG00000016644 radical S-adenosyl methionine domain containing 2 receptor transporter protein 4 RIKEN cDNA 5830443L24 gene RIKEN cDNA A630077B13 gene ring finger protein 213 SAM domain and HD domain, 1 schlafen 4 schlafen 8 serine peptidase inhibitor, clade A, member 3G signal transducer and activator of transcription 1 signal transducer and activator of transcription 2 T-cell specific GTPase tripartite motif-containing 30 tumor necrosis factor superfamily, member 10 ubiquitin specific peptidase 18 ubiquitin-activating enzyme E1-like ubiquitin-conjugating enzyme E2L 6 XIAP associated factor 1 Z-DNA binding protein 1 Intersection Y and G strain (not Brazil strain) Description serum amyloid A 3 Intersection Y and Brazil strain (not G strain) Description 2'-5' oligoadenylate synthetase 3 2'-5' oligoadenylate synthetase-like 1 activating transcription factor 3 allograft inflammatory factor 1 ATPase, class V, type 10A basic leucine zipper transcription factor, ATF-like 2 bone marrow stromal cell antigen 1 bromodomain containing 4 caspase 4, apoptosis-related cysteine peptidase CD40 antigen CD86 antigen cDNA sequence AB124611 cDNA sequence BC013712 chemokine (C-C motif) ligand 2 chemokine (C-C motif) ligand 7 cholesterol 25-hydroxylase complement component 2 complement factor B, Cfb component of Sp100-rs DEAD box polypeptide 60 deoxycytidine kinase eukaryotic translation initiation factor 2-alpha kinase 2 expressed sequence AI607873 Fas death domain-associated protein Fc receptor, IgG, high affinity I fibrinogen-like protein 2 formyl peptide receptor 2 granzyme B GTP cyclohydrolase 1 hemopoietic cell kinase hexokinase 3 histocompatibility 2, T region locus 23 histocompatibility 2, T region locus 24 interferon activated gene 202B interferon activated gene 204 interferon activated gene 205 interferon regulatory factor 1 interferon-induced protein 35 killer cell lectin-like receptor subfamily K, member 1 lectin, galactose binding, soluble 9 lectin, galactoside-binding, soluble, 3 binding protein lymphocyte antigen 6 complex, locus E lymphocyte antigen 86 macrophage expressed gene 1 membrane-spanning 4-domains, subfamily A, member 4C membrane-spanning 4-domains, subfamily A, member 4D membrane-spanning 4-domains, subfamily A, member 6B membrane-spanning 4-domains, subfamily A, member 6C membrane-spanning 4-domains, subfamily A, member 6D membrane-spanning 4-domains, subfamily A, member 8A mixed lineage kinase domain-like Mus musculus, clone IMAGE:4925729 N-myc (and STAT) interactor phosphoinositide-3-kinase adaptor protein 1 placenta-specific 8 plectin 1 poly (ADP-ribose) polymerase family, member 11 promyelocytic leukemia proteasome subunit, beta type 10 proteasome subunit, beta type 8 proteasome subunit, beta type 9 purine-nucleoside phosphorylase 1 pyrin and HIN domain family, member 1 RIKEN cDNA B430306N03 gene RNA binding motif protein 43 schlafen 1 schlafen 5 schlafen 9 similar to ISG15 ubiquitin-like modifier solute carrier family 28 member 2 sterile alpha motif domain containing 9-like T-cell immunoglobulin and mucin domain containing 4 three prime repair exonuclease 1 torsin family 3, member A TRAF type zinc finger domain containing 1 transmembrane protein 140 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) tripartite motif-containing 21 tryptophanyl-tRNA synthetase tudor domain containing 7 tumor necrosis factor, alpha-induced protein 2 zinc finger protein 313 zinc finger with UFM1-specific peptidase domain zinc finger, NFX1-type containing 1 Unique to Y strain D Description a disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 15 adenosine deaminase adenosine deaminase, RNA-specific apolipoprotein B editing complex 1 apolipoprotein B editing complex 3 BH3 interacting domain death agonist caspase 12 cathepsin C cathepsin Z CD180 antigen Cd200 receptor 4 CD48 antigen CD53 antigen CD68 antigen CD72 antigen cell growth regulator with EF hand domain 1 centromere protein J chemokine (C-C motif) ligand 5 chemokine (C-C motif) ligand 6 chemokine (C-C motif) ligand 8 chemokine (C-C motif) ligand 9 chemokine (C-C motif) receptor 5 cholesterol 25-hydroxylase CKLF-like MARVEL transmembrane domain containing 7 complement component 1, q subcomponent, beta polypeptide complement component 1, q subcomponent, C chain complement component 3a receptor 1 cytochrome b-245, alpha polypeptide cytochrome P450, family 7, subfamily b, polypeptide 1 cytotoxic T lymphocyte-associated protein 2 beta DENN/MADD domain containing 2A dermatan sulfate epimerase ecotropic viral integration site 2a ecotropic viral integration site 2b Ena-vasodilator stimulated phosphoprotein endoplasmic reticulum aminopeptidase 1 expressed sequence AI662270 Fanconi anemia, complementation group A F-box and WD-40 domain protein 17 Fc receptor, IgE, high affinity I, gamma polypeptide galactosidase, alpha gamma-glutamyltransferase 5 gasdermin D gene regulated by estrogen in breast cancer protein G-protein signalling modulator 3 granzyme A guanine nucleotide binding protein gamma 2 hexokinase 3 histidine decarboxylase integrin beta 3 interferon alpha responsive gene interferon regulatory factor 2 interferon regulatory factor 8 interferon regulatory factor 9 interferon, alpha-inducible protein 27 interleukin 2 receptor, gamma chain IQ motif containing GTPase activating protein 2 kinesin family member 5C Kruppel-like factor 2 leucine rich repeat containing 8 family, member C leukocyte specific transcript 1 leupaxin lipase, endothelial lymphocyte antigen 6 complex, locus C1 lymphocyte antigen 9 lymphocyte cytosolic protein 2 lysosomal-associated protein transmembrane 5 lysyl oxidase-like 3 macrophage scavenger receptor 1 membrane-associated ring finger (C3HC4) 1 membrane-spanning 4-domains, subfamily A, member 7 Moloney leukemia virus 10 neutrophil cytosolic factor 1 paired-Ig-like receptor A2 phospholipase A1 member A phospholipase D family, member 4 polyribonucleotide nucleotidyltransferase 1 predicted gene, OTTMUSG00000000971 predicted gene, OTTMUSG00000005523 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 prostaglandin I2 synthase protein disulfide isomerase associated 4 protein tyrosine phosphatase, non-receptor type 18 protein tyrosine phosphatase, non-receptor type 5 protein tyrosine phosphatase, receptor type, C proteinase 3 purinergic receptor P2Y, G-protein coupled, 14 ral guanine nucleotide dissociation stimulator,-like 1 RAS-related C3 botulinum substrate 2 receptor (calcitonin) activity modifying protein 2 Rho GTPase activating protein 15 RIKEN cDNA 2610208M17 gene RIKEN cDNA 2810022L02 gene RIKEN cDNA 6330578E17 gene RIKEN cDNA A230046K03 gene ring finger protein 19B ring finger protein 31 schlafen 2 selectin, lymphocyte selenocysteine lyase selenoprotein W, muscle 1 serine peptidase inhibitor, clade B, member 9 serine/threonine kinase 3 SFFV proviral integration 1 signal-regulatory protein beta 1 similar to SP140 nuclear
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