medRxiv preprint doi: https://doi.org/10.1101/2021.05.17.21257345; this version posted May 19, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Title: Delta-9-tetrahydrocannabinol and cannabidiol in psychosis: A balancing act of the principal phyto-cannabinoids on human brain and behavior? Short title: CBD-THC interaction in psychosis Suhas Ganesh1,2, Jose Cortes-Briones1,2, Ashley M. Schnakenberg Martin1,2, Patrick D Skosnik1,2, Deepak C D’Souza1,2, Mohini Ranganathan*1,2 1 Department of Psychiatry, Yale University School of Medicine 2 VA Connecticut Healthcare System, West Haven, CT 06516 *Corresponding Author Corresponding Author Contact Information: Mohini Ranganathan Associate Professor Department of Psychiatry Yale University School of Medicine VA Connecticut Healthcare System/116A 950 Campbell Ave West Haven, CT 06516 Email:
[email protected] Tel: 203-932-5711 X 2546 Fax: 203-937-4860 Word Count: Abstract: 200 Manuscript without online methods: 4463 Figures: main – 3, supplement – 8 Tables: main – 2, supplement – 2 Keywords: delta-9-tetrahydrocannabinol, cannabidiol, psychosis, electrophysiology, neural noise, Lempel-Ziv complexity 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2021.05.17.21257345; this version posted May 19, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.