The NIH Record

U.S. Department December 6 National of Health 1983 Institutes and Vol. XXXV of Human Services No. 25 Health

Dr. Gordon Wallace Huntington's Disease Genetic Marker Gets Veterinary Prize Found by NIH-Supported Scientists

Dr Gordon Wallace, now on detail from NIH A long sought genetic marker for to serve as a senior policy analyst in the Of­ Huntington's disease, a fatal nervous system fice of Science and Technology Policy, Exec­ disorder, has been discovered In humans by utive Office of the President, received the a scientifi c team supported by the National James A. McCallam Award of the Association Institute of Neurological and Communicative of Military Surgeons Disorders and Stroke and the National Insti­ of the United States tute of General Medical Sciences on Oct. 31 . The This landmark finding-locating the marker award was pre­ for the defective gene which causes Hunting­ sented during the ton's disease on a specific chromosome-is Association's 1983 the critical step in developing a diagnostic meeting in San test for the disease, according to Dr James Antonio. F. Gusella, the NINCDS grantee who led the Before undertak­ research team and Is a member of the ing his current du­ Institute-sponsored Huntington's Disease ties in May 1983, Center Without Walls at Massachusetts Dr. Wallace had General Hospital served since 1962 Dr. Wallace "I am optimistic that presymptomatlc and NINCDS grantee Dr. Gusella examines a DNA in the National Institute of Allergy and lnfec­ prenatal diagnostic procedures will emerge sequence for possible variations that could (See VET PRIZE. Page 4) in the near future,"' he said help locate a Huntington's disease gene. Farther down the road, it is hoped the dis­ NEI Sets Nationwide Test On New Drug, Sorbinil, covery will lead to improved treatments and For Possible Prevention of Diabetic Eye Damage even a cure for the disease, which causes in­ voluntary movements, emotional disturbance, People who have had diabetes for 3 to 10 and intellectual impairment. years are invited to participate in a More than 25,000 Americans suffer from nationwide study to find out if the eye prob­ Huntington's disease. which afflicted the late lems and nerve damage which may develop folksinger Woody Guthrie. Another 100,000 in diabetes can be prevented or their devel­ R,un, Americans live with constant dread and anxi­ opment slowed. ety that the same catastrophic fate will befall Investigators at 12 eye care centers, in­ ~l•- them. cluding the Clinical Branch of the National Each child of a parent with Huntington's Eye Institute, will administer a new. investIga­ °"""' disease stands a 50 percent chance of inher­ tional drug called sorbinil in the hope that it ,.,.,_.... iting the disorder Since the illness usually will protect the sight of people who do not yet l,m Blood does not appear until age 35 or later, chil­ have signs of these eye problems, specifical­ dren carrying the defective gene may marry ly diabetic retinopathy. and pass the gene on to the next generation Diabetic retinopathy is a common compli­ before realizing that they have the disease. cation of diabetes which threatens the sight Until now, there had been no way to tell of more than 300,000 Americans. It results who had inherited the disease gene and who from damage to blood vessels in the retina of Diabetic Retinopathy (DR) Is a common eye was free of 11. the eye and eventually can cause visual loss. complication of diabetes. In DR, retinal ves­ The search for the all-important marker led Only those patients who have not yet sels develop balloon-like swellings wh ich can from a tiny village built on stills in a remote developed any significant sign of diabetes­ leak fluid into the light-sensing tissues of the lagoon of a Venezuelan lake to Dr Gusella's related eye damage are eligible for the study retina. These fluid leaks can cause blurred Boston laboratory which uses the most so­ They must be between 18 and 40 years old. vision. phisticated recombinant DNA technology Women must be either postmenopausal. sur­ The investigational drug, sorbInil, Is an al­ The discovery is the culmination of years of gically sterilized, or have an intrauterine de­ dose reductase inhibitor. Researchers in NIH-sponsored basic research directed at vice (IUD) In place NEl's Laboratory of V1s1on Research previ­ finding the marker. All participants must have insul n­ ously identified aldose reductase as an en­ Among Dr Gusella"s collaborators were Dr dependent {Type I} drabetes and have had zyme that may be implicated In the destruc· Nancy S Wexler. a former '\JINCDS stall no recent s1gnifrcant change in the frequen­ live effects of diabetes throughout the body member who now heads the Hered,tary Dis­ cy of insulin in1ec11ons or In blood glucose Their laboratory findings suggested that in­ ease Foundation, and Dr P. Michael managemnt w1t~,n 3 months of entering this hibitors of aldose reductase, such as sorbinil, Conneally, a grantee of NINCDS and NIG\olS study. (See EYE TEST, Page SJ (See MARKER Page 7) The NIH Record

Pubhshed b iweekly at Bethesda, Md., by lhe Editorial Opera­ tions Branch. Division of Public In formation, for the informa11on of employees of the Nahonal lns1ttutes of Heallh, Oepartme~t of Health and Human Services, and c 1rcula1ed by reques1 to w,11ers and to research ers m b1omedrcal aod related fields The con tent i s reprintabte without perm1ss1on. Pictures may be available on ,eQuesL

The NJH Record reserves the right to make corrections. chan ges, or deletions In submilted copy in conform,ty with the policies of fhe paper and HHS.

NIH Record Otllce Bid~ 31, Room 28-03, Phone 496-2125

Editor Herschel Cribb

Stall Writer• Editorial Aulatant Joyce F. McCarthy Marilyn Be,man Anne Barber

Staff Correapondents CC. Barbara SmaKula: DCRT, William Hall; DPM, Judy Fouche; DAG, Sue Meadows, DAR, Barbara Menick, DRS, Jim Doherty; Dr. James B. Wyngaarden, Director of NIH, (seated), signs a letter encouraging m_embers of the FIC, Susan P, Stark; NCI, Patricia A. Newman, NEI. Marsha NIH community to join the Recreation and Welfare Association. Looking on are (I to r) Randy Corbett; NHLBI, Bill Sanders; NIA, Clarissa Wittenberg; NIAID. Schools, R&W general manager, Leo Buscher, 1st vice president, and Agnes Richardson, presi­ Jeanne w,nnlcK; NIADDK, Barbara Weldon; NICHD. James Hadley; NIDA, Sally Wilberdlng; NIEHS, Hugh J. Lee; NIGMS, dent of the R&W. Wanda warddell; NIMH, Harry Bell; NINCOS, Diane Strlar; NLM, Roger L. Gilkeson. R&W Begins 1984 Membership Drive The NIH Recreation and Welfare Associa­ candies. Those interested in protecting their tion begins its 1984 membership drive in De­ families can obtain group insurances rates Training Tips cember and early birds can save 40 percent for dental care, hospital insurance, automo­ The following courses, sponsored by the by purchasing their cards during December biles, or term life. Division of Personnel Management are given and January. For these 2 months only cards The overall welfare of employees and pa­ in Bldg. 31 . can be purchased at all R&W gift stores or tients is not overlooked either. The R&W from BID representatives for $3, a savings of holds many educational seminars for all em­ Course $2 over the regular annual $5 fee. ployees at NIH and supports the NIH Patient Office Skills Starts Deadline Scientific Terminology 2/7 1/17 Why join R&W? What are the advantages of Emergency Fund and special events on the membership? How about a whole range of campus on a regular basis. Executive, Management and activities from sports clubs- softball, golf, The R&W invites NIH workers to join with Supervisory hiking- to groups for shutterbugs or compu­ more than 10,000 of their coworkers as mem­ Federal Budget Process 1/25 1/9 terniks? Or, if you prefer travel, group pack­ bers of the R&W. Watch for special member­ Manage Your Meetings 1/24 1/6 age rates to the Caribbean, Mexico, Europe, ship drives in the BIDs, see your representa­ Understanding and Managing 2/22 2/6 Stress or just a weekend of backpacking or white tive, or come to the R&W stores or activity Ma11aging Performance Feed- 2/8 1/20 water rafting. desk to join. You will receive the handsome back Then, there are the R&W stores offering a calendar with discount merchants and spe­ wide range of gifts for all occasions or just to cial events listings, and enjoy another excit­ Communication Skills show you care- watches, pens and pencils, ing year of R&W activities. D Assessment One: Job Analysis 1/11 12/12 cards, small appliances, or exotic teas and Interpersonal Problem Solving 1/24 12/19 Effective Oral Communication 2/27 1/23 Advanced Assessment 3/5 1/30 NIH Sons of Italy To Present Parking Changes DELPRO • Delegated Procurement 1/9 12/22 Italian Food Xmas Celebration Beginning Tuesday, Jan. 3, 1984, all carpool • For new Delpro users only. Italian food lovers: Attenzione! spaces will be reserved for carpools only until 10:30 a.m., instead of 2 p.m. After 10:30 a.m., To learn about these and other courses, Eat a light lunch (if any) on Tuesday, Dec. 20, employees with general parking permits will be contact the Development and Training Oper­ because the new NIH Lodge of the Order Sons permitted to park in all carpool spaces. This ations Branch, DPM, 496-6371 . of Italy in America (OSIA) will have a special treat for you that afternoon from 3 to 5 p.m. in change is being made to help alleviate the present mid-morning parking problems. Remember the Patient Emergency Fund the Bldg. 10 cafeteria. The newly organized lodge is sponsoring a Reserved parking for carpoolers until 10:30 The holiday season is a time for giving. NIH "Suon Natale" (Merry Christmas) celebration, a.m. will ensure continued convenient. close-in parking for carpoolers when arriving at the NIH employees have a special opportunity to give featuring favorite Italian food delicacies. The by donating to the Patient Emergency Fund. proceeds will be donated to the NIH Patient NIH encourages all employees to carpool, as The PEF provides services not supported by Emergency Fund in the Clinical Center. carpooling allows each of us to conserve ener­ appropriated funds, such as assistance to fami­ Food can be eaten in the cafeteria or taken gy and protect the environment. lies who are here to give patients emotional and home. Some of the available homemade items Parking Past 3 p.m. physical support. The PEF also assists in trans­ are: pasta, meatballs, cheese, cannoli, sau­ portation expenses. The continued support of sage, pizza sauce, soups, zucchini bread, Ital­ After 3 p.m., employees will be able to park the NIH employees can make an enormous dif­ ian bread, desserts. in any designated space: general employee, ference in the lives of the CC patients. Contri­ During the celebration, you can relax, sip carpool. preferential (red). and visitor areas. butions can be mailed to the R&W Office, Bldg. your cottee, and enjoy listening to seasonal mu­ This does not include reserved (numbered), 31 A, Rm. B1W30, or to the Social Work Depart­ sical recordings of Italian Childrens' Choirs. D handicap, and Day Care Center spaces. D ment. Bldg. 10 (ACRF), Rm. 1C144, or dropped at any R&W Gift Shop. D

Page 2 The NIH Record December 6, 1983 New Shuttle Bus Schedule Takes Effect Jan. 1 Dr. Decesare, ORR, On Tuesday, Jan. 3, 1984, the NIH shuttle leaving the Westwood Bldg. will go directly to bus which travels between the campus and Bldg. 10. Dies of Heart Attack the Westwood, Federal, Landow, and Bloch Thirteen (13) shuttles will stop at Bldgs. Dr. William R. Decesare. director of the Bldgs. will begin an all-new, improved 12A, 36, and 38; 10 shuttles will stop at the General Clinical Research Centers Program schedule. The number of daily round trips will Bloch Bldg. The remaining 16 shuttles will be in the NIH Division of Research Resources, be increased and the quality of vehicles im- express shuttles, stopping only at Bldgs. 1O d ied of a heart attack Nov. 22. He was 50 proved. The shuttle schedule serving the and 31 , and the Federal, Landow, and West- years old. Blair Bldg. will not be changed. wood Bldgs. The complete shuttle schedule Born in 1933 in East Orange, N.J., Dr. Forty (40) shuttles will travel between the serving the Westwood Bldg. is shown below. Decesare g raduated cum laude from campus and the Westwood Bldg. daily. Shut- To provide a more comfortable, smoother Iles will leave both locations at 25-minute in- ride, full-size busses now in use will be re- tervals. The first shuttle going to the placed with newer 12- and 15-passenger Westwood Bldg. will leave Bldg. 10 at 8 a.m.; vans. the last at 3:55 p.m. A separate shuttle going The Vehicle Dispatch and Shuttle Section to the NIH campus will leave the Westwood will operate this new shuttle schedule as a Bldg. at 8:25 a.m.; the last at 4:20 p.m. 3-month trial, monitoring ridership. After 3 Throughout each day a total of 20 shuttles months, further changes in the schedule may will leave both the campus and the be made as necessary. Westwood Bldg. Suggestions for additional improvements Thirty-nine (39) of the shuttles will stop at to the shuttle service are welcome. Pl ease Bldgs. 10 and 31, and the Federal, Landow, forward your comments to Cheryl Amatucci, and Westwood Bldgs. The 4:20 p.m. shuttle Bldg. 31, Rm. 4830. N.I.H SHUTTLE SCHEDULE WESTWOOD TO N.I.H.

West- Building wood Landow 'Federal 38 12A 36&37 RAB 31 10 Dr. WIiiiam R. Decesare 8:25 8.38 8:40 8:46 8:48 Dartmouth College in 1955 and was awarded his medical degree from Harvard Medical 8:50 9:03 9:05 909 912 9:13 School in 1958. He interned, did a residency, and was a research fellow at the Dartmouth 9.15 9:28 9:30 9:34 9:35 9:37 9:38 9:39 Medical Center from 1958 to 1963. 9"40 9:53 9:55 10:00 10:03 He then spent 3 years at Georgetown Uni- versity Medical School in Washington, D.C. 10:05 10:18 10:20 10:24 1027 10:28 as a research fellow and instructor in medi- cine before joining NIH in 1966 as assistant 10:30 10:43 10:45 10:48 10:49 10:51 10:53 10:54 director of the General Clinical Research Centers Program. In 1968, he was named di- 10:55 11 :08 11:10 11: 19 11:20 rector of the program which funds 75 special hospital units for c linical research purposes 11 :20 11:33 11 :35 11 :39 11:40 11 :42 11 :44 11 :45 at academic medical centers throughout the 11:45 11: 58 12:00 12:04 12:07 12:08 country. Dr. Decesare was awarded a Commenda- 12:1 0 12:23 12:25 12:29 12:30 12:32 12:34 12:35 lion Medal in 1978 from the Public Health Service for introducing significant innova- 12:35 12 48 12:50 12:55 12:56 tions whic h have expanded the capability and cost effectiveness of General Clinical 1:00 1:13 1:15 1 19 1:20 1:22 1:24 1:25 Research Centers. He was the author of numerous publica- 1:25 1:38 1:40 1:48 1:49 lions in clinical research, hematology, and 1:50 2:03 2:05 2:09 2:12 2:13 radiobiology. Dr. DeCesar served on several NIH committees and was a member of the 2·15 2:28 2:30 2:34 2:35 2:37 2 39 2:40 American Federation for Clinical Research. the American Association for the Advance- 2.40 2:53 2:55 2:59 3:00 ment ot Science, and the Society of Clinical Trials. 3:05 3:18 320 3:24 3:27 3:28 The Dean, faculty, clinical researchers and staff of the New York University Medical Cen- 3:30 3:43 3:45 3:49 3:50 3·52 3:54 3:55 ter paid high tribute to Dr. Decesare. " Dr. 3:55 4:08 4:10 4:15 4.20 Decesare was a wise, skillful and committed shepherd of an important aspect of our na- 4:20 4:55 tional quest to comprehend and apply ad- vances in basic· research in the care of our 'Pickup across streel at Commerce Lane entrance. people," said Dr. Saul J . Farber, dean prov- • 'Pickup bus at SW. corner of building 29A. ost and chairman of medicine, NYU Medical Center. "His studious, thoughtful and imagi- How To Cope With Holidays Blues native leadership were instrumental in nurturing clinical research in this country," he The Employee Assistance Program of the Morris Schapiro, mental health counselor, will added. Occupational Medical Service will present the offer several different methods on how to deal Survivors include his wife, Eleanor, and annual program, "How to Cope with the Holiday with the problem as well as place it in historical three daughters, Carolyn, Martha Jane and Blues," on Wednesday, Dec. 14, from noon to 1 perspective. For further information, call Robin Ray, all of Bethesda, and a brother, p.m. in Bldg. 31, Rm. B2B57. 496-3164. D James C. of Kansas City, Kan.

December 6, 1983 The NIH Record Page 3 New Exercise Class Being Offered Monoclonal Antibodies Isolated in Autoimmunity Studies At NIH Fitness Center in January What do diabetes, arthritis, systemic lupus producing part of the pancreas that tails in Exercise classes are now open to all- no erythematosus, and rheumatic heart disease diabetes millitus. membership required, and you can enjoy the have in common? These are 1ust a few of Twenty-four of the hybridomas made anti­ many diseases that may involve an immuno­ pituitary autoantibodies, eleven made convenience of taking exercise classes on a logical "mistake" in which the body produces autoantibodies against gastric mucosa, and drop-in, pay-as-you go basis. The new winter session of exercise classes antibodies against itself. five made antinuclei antibodies. Several of w ill begin Jan. 3 and run for 12 weeks. All Usually, immune responses destroy invad­ the antigens recognized by these monoclona ing bacteria, viruses, and tumors. However, antibodies have been identified as hor­ c lasses will be held at the NIH Fitness Center when misdirected, they may destroy the pa­ mones, including glucagon, growth hormone, (T- 39). In addition to the regular classes in tient's own tissues. and insulin. Aerobic Action (Aerobic dancing) and Alive! Although scientists know little about what In addition to autoantibodies that react wit~ (slimnastics and calisthenics) a new coed ex­ triggers the production ot these autoanti­ single organs, the NlDR scientists isolated ercise class, Ouik Fit, is now being offered. bodies, viruses have been suspected as one autoantibody-secreting hybridomas from in­ Quik Fit of the possible causes. fected and uninfected animals that reacted Under the direction of Dr. Abner Louis with multiple organs. The findings suggest Ouik Fit is designed to give you a total Notkins, chief of the National Institute of Den­ that these monoclonal autoantibodies either work out in a minimal amount of time. This 45 tal Research Laboratory of Oral Medicine, recognize the same molecule present in dif­ minute class includes stretching, strengthen­ scientists are examining the role of viruses ferent organs or a common antigenic deter­ ing, muscle toning, stomach exercises, en­ and immunity in human and experimental minant of different molecules found in multi­ durance exercises, and relaxation routines. models of d iabetes. Recently, these investi­ ple organs. Class fees for a full membership, $2 per g ators advanced their exploration through In humans, many children with insulin­ c lass when you sign up for the session: non­ the successful production of mouse and hu­ dependent diabetes mellitus (IDDM) have members, $2.50 per c lass: or drop-in to the man monoclonal autoantibodies in culture. autoantibodies in their blood that react with class and time of your choice for $3 per The availability of large quantities of these pancreatic islet cells. In some cases, these c lass. Drop-in on a space available basis autoantibodies should allow the scientists to islet cell antibodies precede the develop­ and adjust to class. identify the antigens these antibodies recog­ ment of IDDM by months, or even years. Although medical screening is not re­ nize, the role these antibodies play in These antibodies appear to be a useful prog­ quired, partic ipants are urged to consult with autoimmune diseases, and whether different nostic indicator for identifying individuals at their personal physician before beginning individuals with the same disease develop risk of developing the d isease. any Fitness Center activity. autoantibodies against the same molecules. Carrying their research one step further, Ouik Fit- Monday, Wednesday, and Fri­ Dr. Notkins and Drs. Jo Satoh, Bellur S. day, noon to 12:45 p.m.; and 5:15-6 p.m. Autoantibody Reaction Prabhakar, Martin V. Haspel, and Fredd a Aerobic Action- Monday and Wednesday, In certain autoimmune diseases, autoanti­ Ginsberg-Fellner successfully isolated 6-7 p.m. bodies are found that react with a number of autoantibodies from humans that react with Alive!-Tuesday and Thursday, 5-6 p.m. organs. One of the difficulties in studying antigens in multiple organs. and 6-7 p.m.; Saturday, 9-10 a.m. these diseases has been determining wheth­ Peripheral blood lymphocytes from pa­ Sign up at the R&W Activities Desk in Bldg. er a variety of autoantibodies actually exist, tients with insulin-dependent diabetes and 31 or the Fitness Center. Registrations will be each reacting with a different organ, or other autoimmune abnormalities were fused accepted through Jan. 20. For more informa­ whether the autoimmune response is more with either mouse or human myelorna cells. tion call 496-TAIM. □ restricted, with only a limited number of Human monoclonal autoantibodies were ob­ autoantibodies recognizing common anti­ tained that reacted with multiple endocrine VET PRIZE agens in different organs. (hormone-secreting) and nonendocrine (Continued from Page 1) Researchers in the Laboratory of Oral Med­ tissues. icine had previously shown that mice in­ The NIDR investigators po.stulate that these tious Diseases as an investigator and fected with the virus known as reovirus type 1 antibodies may be a partial explanation for administrator. develop an autoimmune disease of the endo­ the multiple organ autoimmunity seen in cer­ The McCallam Award, honoring the late c rine glands characterized by mild diabetes tain autoimmune diseases. Brig . Gen. James A. McCallam, a former mell1tus and retarded growth. Using these monoclonal antibodies, the c hief of the U.S. Army Veterinary Corps, is Autoantibodies against the pancreas, pitui­ scientists are beginning to isolate the specif­ awarded by the association to a Doctor of tary g land, and mucous-secreting cells of the ic tissue antigens with which these antibod­ Veterinary Medicine in recognition of out­ d igestive tract were found in blood samples ies react. Thus, these monoclonal antibodies standing accomplishments in the field of from these mice. The presence of an im­ are making it possible to identify some of the medicine and health. munological component was confirmed when autoantigens involved in human autoimmune Infectious Diseases immunosuppression was shown to prevent d iseases.- Jody Dove autoantibody formation, diabetes. and g rowth Much of Dr. Wallace's research has been retardation. focused on eosinophilic meningitis, toxoplas­ In order to learn more about the role these Note: This research has been reported in Sci­ mosis, swine flu and other infectious d is­ autoantibodies actually play, the scientists ence, Apr. 15, 1983; Nature July 7, 1983, and the eases important in the Pacific area. needed a larger amount of the antibodies New England Journal of Medicine, July 28, He was named assistant scientific d irector 1983. D than could be isolated from blood samples. of NIAID in 1978. In 1979 mousepox (a dis­ Using cell hybridization techniques, ease severely threatening inbred mouse col­ Dr.Notkins, together with Ors. Martin V. NHLBI Seeks Sickle Cell Volunteers onies essential for biomedical research) was Haspel, Takashi Onodera, Bellur S. discovered at NIH. Prabhakar, Masakazu Horita, and Hoshibumi The National Heart, Lung, and Blood Institute Dr. Wallace became involved in studies of Sukui, conducted experiments in which they is currently recruiting black individuals between this disease and, in addition to administrative fused spleen cells from mice with virus­ the ages of 20-35 to serve as normal controls duties, managed the laboratory work in a induced autoimmune disease with myeloma in a study designed to establish some of the mousepox project supported by several NIH cells. Individual hybri domas were cultured, earliest manifestations of sickle cell eye institutes. each producing a clone of cells that pro­ disease. A serologic assay for detecting ectromelia duced large amounts of identical antibodies. Vol unteers will receive a comprehensive (mousepox) antibody has been developed in The scientists were able to generate a medical and ophthalmological evaluation, in­ the project, which has also included an eval­ large panel of autoantibody-secreting cluding selective blood studies. For further in­ uation of current immunization procedures for hybridomas, including 14 that reacted with formation, contact Bonnie Collier at mouse colonies and a study of virus trans­ cells in the islets of Langerhans, the insulin- 496-5846. D mission in inbred mouse colonies. D

Page 4 The NIH Record December 6, 1983 NLM Exhibits Paintings, Sketches by F. Armitage Platelet Donor Sets Record Selected work by one of America's fore­ On Oct. 28, Kenneth R. Carter set an NIH most medical illustrators, Frank Armitage, is record-he completed his 500th platelet do­ now on display in the NLM main lobby where nation. Ken is a fire protection inspector and it will remain through January 1984. a regular NIH platelet donor. Mr. Armitage, who worked with Walt Disney Platelets are small cells which circulate in in the 1950s on a number of his animated the blood stream. They are needed to stop motion pictures, has more recently been rec­ bleeding when organs or blood vessels are ognized as a versatile illustrator whose work damaged. Patients with aplastic anemia or goes beyond the literal representation of leukemia do not have enough platelets and medical subject matter. can easily bleed to death. Platelet trans­ The NLM exhibit features six large paint­ fusions save lives. ings depicting the retina in progressive Many patients who receive " unmatched" or stages of modern abstraction, two works random platelet transfusions will become im­ showing the artist's conception of the neuron mune to platelets. This means that transfused jungles of the brain, and a number of platelets will be destroyed by the patient's sketches and paintings related to surgery ow n antibody system. and the blood and nerve cells in the hand. For this reason whenever possible, "matched" platelets from individuals who In a short videotape accompanying the ex­ hibit, Mr. Armitage explains the process by have a platelet type very similar to the patient which he conceives and executes his paint­ are used for transfusions. ings. " Most of the time I use nonanatomical Typing Platelets color and treat the whole (visual) statement Precise typing of platelets is not yet possi­ as a painting. This, I feel, is important to me ble. Compatible platelet transfusions can be as I was trained as a painter first, and I ac­ achieved by matching the human leukocyte quired some medical knowledge later-and I antigen (HL-A) type between the donor and put the two together. Underlying it all Is a the recipient. painting in an abstract form. This is the foun­ Ken Carter has what is considered a "com­ dation I work on, and I overlay it with medical mon" HL-A type which means he is a scientific information." compatible donor for many patients. He has The exhibit was organized by Drs. Charles This is "Abstract Depiction of Rods and Cones type O-negative blood which means his F. Bridgman and Biagio J. Mellom, both dis­ of the Retina" (acrylic), by Frank ~rmitage dis­ p latelets are sometimes saved for patients tinguished medical illustrators in NLM's Lister played in the main lobby of the NLM. requiring Rh-negative blood products. Hill Center. Ken has participated in this program for A native of Victoria, Australia, Mr. Armitage his studies at Chouinard's Art Institute and over 1 0 years. He started g iving platelets to studied painting immediately after World War joined the staff of the Disney studios. With help sick children simply because he was II at Ontario College in Canada. Under a Disney he helped develop a number of ani­ grateful to have healthy children of his own. scholarship he then studied with muralists in mated films. He emphasizes that the· donation proce­ Mexico City at the National Polytechnical In­ An association with stall at the UCLA Medi­ dure is simple and painless. Withdrawal of 4 stitute. There he served as an assistant to cal School led him into studying medical sub­ pints of blood, one at a time, is required. Fol- David A. Siqueiros, Mexican muralist, and de­ Ject matter and preparing medical drawings veloped his unusual skills for dramatizing vis­ and paintings for exhibits and publications. ual information on a large scale. He is currently preparing three-dimensional He emigrated to the United States in 1952, anatomical representations to be d isplayed settling in Los Angeles where he continued at the EPCOT center, Disney World, Fla. D

EYE TEST and safety of sorbinil treatment. The study is the latest in a series of NEl­ (Continued from Page 1) fostered clinical trials to evaluate various might slow or halt the enzyme's destructive means of preventing and treating the harmful effects on cells in the eyes, nerves, and other effects of diabetes on the eye. tissues. Several years ago, a national collaborative In diabetic animals, it has been shown that study demonstrated that photocoagulation aldose reductase inhibitors do in fact prevent can substantially reduce the risk of blindness some of these complications from in people with advanced diabetic developing. retinopathy. Because of the success of these studies, Then NEI began supporting a clinical trial the NEI is collaborating with the developer of to test the effectiveness of laser the drug, Pfizer Inc., on the new, multicenter photocoagulation in preventing advanced­ c linical trial. It will compare sorbinil's effec­ stage retinopathy from developing in people tiveness to that of a placebo in preventing or who have early-stage d iabetic retinopathy. slowing the progression of diabetes­ Now, with the sorbinil study, NEI is testing associated retinopathy and nerve damage. the preventive effects of a drug which may Each of the 12 participating centers will en­ benefit those without any clinical signs or roll 70 patients. Half of the 70 patients will be symptoms of diabetic r~tinopathy. Kenneth Carter gives his 500th platelet randomly assigned to the treatment group For additional information on enrolling in donation. and will take one sorbinil tablet each morning the sorbinil study, write or phone Dr. Monique for 135 weeks. The other hall will be the S. Roy, National Eye Institute, Bldg. 10, Rm. lowing the collection of each pint of blood, nontreatment group and will take a placebo 10N313, Bethesda, Md. 20205 or (301) tile platelets are removed and the red blood tablet each morning for the same number of 496-5846. D cells and plasma are returned to the donor. weeks. Both groups will be tested and exam­ The need for platelet transfusions is critical ined by physicians 15 times during the 2½ One of the chief objects of medicine is to and you could be a donor. For information year study. The data from all 12 centers will save us from the natural consequences of call the NIH Plateletpheresis Center on be evaluated to determine the usefulness lo ur vices and follies.-H.L. Mencken □ 496-4321 or 496-2022. D

December 6, 1983 The NIH Record Page 5 Clinical Center Celebrates 30th Anniversary: Seven Scientists Served Shines in Patient Care and Medical Research Clinical Center as Directors Designed by ACRF architects in conIunc­ Seven Directors- a group or outstanding tion with Earl Walls, a c onsultant architect scientific researchers, clinicians and specializing in laboratory design, the labora­ administrators - have served the Clinical tory consists of a large open room divided Center during the past 30 years. They are: into separate work areas. Each work area has • Dr. Jack Masur served as NIH Associate a center rectangle with bench space on ei­ Director for Clinical Care and Director ol the ther side in the shape of the letter C. This Clinical Center during its planning and con­ gives the technologist a sense of privacy struction from 1948 to 1951 . combined with a feeling of openness. The Dr. Masur had height of the benches is adJustable and the earlier d irected the cabinets can be easily moved from one area medical care pro­ to another. This feature will save the expense ( grams of the PHS and effort of renovations over time. by administering its In the center of the room is a transport sys­ hospitals and other The Clinical Center after the ACRF was tem which automatically transports most facilities, including completed in 1981. specimens to the laboratory. After they are Freedman's Hospi­ Since the first patient was admitted to the received and processed, specimens are de­ tal in Washington, Clinical Center in July 1953, NIH's research livered to the respective services for appro­ D.C hospital has been dedicated to high quality priate analysis. • Dr. John patient care while remaining at the forefront The new laboratory has proven to be effi­ Trautman was Clini- of biomedical research. cient in using space and technology to han­ Dr. Masur cal Director from Thirty years later, the Clinical Center now d le a large and critical workload. July 1, 1951 to June 24, 1954, after serving as admits over 7,500 inpatients and treats more Diagnostic Radiology d irector of the PHS Staten Island Facility's than 100,000 outpatients a year. 985-bed hospital. With the dedication of the Ambulatory Care The Diagnostic Radiology Department • Dr. Donald W. Patrick served as Clinical Research Facility on Oct. 22, 1981 , the Clini­ moved to ACRF this past spring, providing a Center Director from June 23, 1954 through cal Center began a new era in patient care newer and more spacious environment to ac­ Oct. 30, 1956. He was medical officer in and clinical research. Addition ol the ACRF commodate its space-age technology. It has charge of PHS hospitals in Evansville, Ind., to the Clinical Center, which is dedicated pri­ already increased its diagnostic capabilities. Detroit, and Baltimore before coming to NIH. marily to outpatient care, will eventually in­ The new computerized tomography area • Dr. Thomas C. crease outpatient visits to about 200,000 a houses a new "fourth generation" scanner Chalmers came to year. Many more noninvasive procedures that accompanies the department's first CT NIH in February can now be performed on an ambulatory ba­ machine. CT scanners take static multiple im­ 1970 as NIH Asso­ sis rather than hospitalizing patients as in the ages that are then reconstructed by comput­ ciate Director for past. er to provide sophisticated images of the Clinical Care and The 13-story glass ACRF structure houses structure of the body. CC Director Previ­ clinics, laboratories, operating rooms, an In addition, the new biplane fluoroscope ously, he had been ampitheater, a Visitors Center, and large unit mixes X-rays in two planes of the body at assistant chief to open waiting rooms. It is connected to the once, eliminating the need to turn the patient. the Medical Direc­ 14-story all-brick Clinical Center by walkways The department has also received a Nucle­ tor for Re searc h located on most floors. ar Magnetic Resonance (NMR) unit which will and Education at ACRF construction began in June 1977 as be operational early next year. At the fore­ the Veterans Ad- part of the modernization and expansion pro­ front of diagnostic technology, the NMR uses Dr. Lipsett ministration in gram to strengthen the combined laboratory magnetic fields and radio waves to provide Washington, D.C. and patient-care activities. 3-dimensional images of the internal struc­ • Dr. Robert S. Gordon Jr., was named The open-spaced lobby complete with sky­ ture of the body. These images will help CC Director of the Clinical Center and NIH Asso­ lights and plants serves as the NIH Visitors scientists to better d iagnose such conditions ciate Director for Clinical Care in 1974. He Center, exhibit area, and patient lounge. The as brain disorders and cancer. CT scans re­ came to NIH in 1951 as a senior investigator first floor houses the admission section, So­ veal density; NMR shows the contents and in the Laboratory of Metabolism in the Nation- cial Work, Patient Activities, Diagnostic Radi­ surroundings of tissue. al Heart Institute. · ology, and Nuclear Medicine Department. The combination of updated machinery • Dr. Mortimer The Clinical Pathology and Surgery De­ and space has enhanced the diagnostic ca­ Lipsett is currently partments and Administrative offices occupy pability of the department and increased the the Director of the the second floor. ease and speed with which tests are com­ National Institute of Floors 3 to 13 are alike. Each has c linic pleted and recorded. Child Health and rooms on the west side, laboratories on the New systems for handling information gen­ Human Develo p­ east side and isolated animal areas located erated by diagnostic scans have been built ment. He was Clini­ on the southeast corner of each floor. into the department's new facilities. As scans cal Center Director Two years into operatfon, the ACRF has are completed, radiologists read films in from 1976 to 1983. helped to open the way to clinical research of viewing areas outside of each scanning Before his appoint­ the future. room. They then dictate their interpretation of ment as Clinical Some key services are outlined below: films directly into a central recording system. Center Director in This information is immediately entered into Clinical Pathology 1976, he was direc­ the Medical Information System, allowing the Dr. Decker tor or Cancer Cen­ The Clinical Pathology Department's spa­ results to reach requestors much sooner than ter, Inc. in Cleveland, a research training and cious and innovative laboratory was dedi­ before. patient care facility. cated on Mar. 10, 1982 and has conducted One of the largest such facilities in the • Dr. John L. Decker is currently Clinical about 2.8 million tests a year since then. area, the Clinical Center's Diagnostic Radiol­ Center Director and NIH Associate Director The department has three services: clinical ogy Department carries out thousands of di­ for Clinical Care, a position he had held since chemistry, hematology, and microbiology. agnostic tests a year (over 60,000 in 1982) August 1983. He is an internationally recog­ Besides performing laboratory tests, the and conducts research that has contributed nized expert In rheumatic disease and was hematology service also provides a consulta­ to important innovations in radiological tormerly chief of the Arthritis and Rheumatism tion service in clinical hematology. practice. D Branch. NIADDK. D

Page 6 The NIH Record December 6, 1983 The scientists made several month-long MARKER expeditions to the village to perform neuro­ logical examinations and collect skin and Visiting Scientist (Continued from Page 1) blood samples from 570 descendants of the who directs the NINCDS Huntington's Dis­ Venezuelan woman. Program Participants ease Research Roster at Indiana University. Meanwhile, back in the lab, Dr. Gusella Sponsored by Fogarty International Center The Research Roster, two Huntington Dis­ was testing his DNA sequences in the Ameri­ 8/31- Dr. Paul West, Canada. Sponsor. Dr. ease Centers Without Walls, and the Vene­ can family. He saw a glimmer of hope when Ronald Mason, Laboratory of Environmental B10- zuelan research proJect were funded by his findings suggested that a sequence of phys,cs, NIEHS, RTP, NC. NINCDS on recommendation of the Congres­ chromosome 4 might lie c lose to the Hunting­ 10/7- Dr. Vincenzo Sorrentino, Italy. Sponsor· sionally-mandated Commission for the Con­ ton's d isease gene. But the data were not Dr. Mariano Barbacid, Laboratory of Cellular and trol of Huntington's Disease and Its Conse­ strong enough. Molecular Biology, NCI, Bg. 37, Rm. 1A07_ 11/1 Dr. Long Fong Cheng, Taiwan. Sponsor: Dr. quences, which was convened d uring the He then used the same DNA segment to Maija I. Mednieks. Laboratory of Oral Biology and late 1970s. test the Venezuelan samples, which are cur­ Physiology, NIDA, Bg. 30, Rm . 21 1. This pioneering venture not only dramatic­ rently stored at the NIGMS-supported Human 11/1 Dr. Chu Kun-Hsiao, China. Sponsor: Dr. ally alters the course for Huntington's d is­ Genetic Mutant Cell Repository in Camden, Richard Asofsky, Laboratory of Microbial Immuni­ ease research, Dr. Gusella said, it also offers N.J. ty, NIAID, Bg . 5, Rm . 235. hope that gene locations for other inherited Finally, Ors. Gusella and Conneally ana­ 11/1 Dr. Martine Coue, France. Sponsor: Dr. illnesses such as cystic fibrosis and familial lyzed the computerized DNA data from the Stephen Brenner, DCRT, Bg. 3, Rm. 302. Alzheimer's disease may now be found. United States and Venezuelan families. The 11/1 Dr. Ettore D'Ambrosio, Italy, Sponsor: Dr. "' The technologies developed to find this answer was unequivocal. The marker had Anthony Furano, Laboratory of Biochemical Phar­ marker are immediately transferable to other been found, lying on chromosome 4- ex­ macology, NIADDK, Bg 4, Rm . 104. 11/1 Dr. Chou-Zen Giam, Taiwan. Sponsor: Dr. diseases," said Dr. Wexler, who served as tremely close to the Huntington's disease George Khoury. Laboratory of Molecular Virology, executive director of the Huntington's Dis­ gene. NCI, Bg. 41. Rm. 200. ease Commission and oversaw the NINCDS The diagnostic potential of the Hunting­ 11 11 Dr. Derek LeRolth, South Afnca. Sponsor: Huntington's Disease research portfolio until ton's disease marker is particularly valuable Dr. Phillip Gorden, Diabetes Branch, NIADDK, this past June. because the disease begins insidiously­ Bg. 10, Rm. 9N222. Other candidate d isorders for this scientific with minor c lumsiness or forgetfulness. The 11/1 Dr. Shuzo Matsushita, Japan. Sponsor: Dr. approach include neurofibromatosis and illness is easily misdiagnosed, which can Samuel Broder, Laboratory of Clinical Oncology, manic-depressive illness, both of which in­ cause misunderstanding and family NCI, Bg . 10, Rm . 6B15. volve aberrations of the nervous system. problems. 11/1 Dr. John Gerard Morgan, Ireland. Sponsor: Dr. Gerald R. Crabtree, Hematopathology Sec­ The d iscovery of a marker for a Hunting­ Example: For years Woody Guthrie was tion, NCI, Bg. 10, Rm . 2N113. ton's disease gene was a major goal of Dr. thought to be alcoholic until doctors finally 11 /1 Dr. Kenzo Ono, Japan. Sponsor: Dr. Gusella's project for NINCDS's multi­ determined that he had the d isease. Monique Dubois-Dalcq, Section on Neural and institutional Centers Without Walls. The As the disorder progresses, brain cells d ie. Molecular Ultrastructure. NINCDS, Bg. 36, Rm. achievement, reported in Nature, Vol. 306, All parts of the body are in constant uncon­ 5C10. (Nov. 17, 1983), was gained with astonishing trollable movement: speech becomes unin­ 11/1 Dr. Edward J. Pearce, United Kingdom: rapidity in only 3 years. telligible, and choking is a hazard. Although Sponsor: Dr. Alan Sher. Laboratory of Parasitic To find the marker, Or. Gusella combined intellect deteriorates, insight and orientation Diseases, NIAID, Bg. 5, Rm. 212. classic principles of genetics with the most often remain. Depression is common and the 11 /1 Dr. Stefania Pittaluga, Italy. Sponsor: Dr. Jeffrey Gossman, Laboratory of Pathology, NCI. advanced recombinant DNA techniques. suicide rate high. Death comes after 1O to 20 Bg. 10, Rm. 2N108. Classical genetic studies indicate that if years of decline. There are no remissions. 11/ 1 Dr. Shingo Tsuyama, Japan. Sponsor: Dr. two genes lie close together, they are inher­ Unfortunately, treatment is only marginally Martin Flavin, Section on Organelle Biochemistry, ited together. Beginning from this essential effective. Often the illness affects several in a NHLBI, Bg. 3, Rm . 125. premise, Dr. Gusella added new techniques family at the same time. Because the burden 11/ 1 Dr. Pierre Voisin, France. Sponsor: Dr. Da­ that allowed him to isolate specific se­ of this disease is felt by rel-atives and friends vid C. Klein, Section on Neuroendocrinology, q uences of DNA, some of which he hoped of the afflicted person, the disorder actually NICHD, Bg. 6, Rm. 1A15. would tie close enough to the Huntington's affects hundreds of thousands of lives. 11 /1 Dr. Kentaro Yamaguchi, Japan. Sponsor: d isease gene to be inherited with it and Since each at-risk individ ual has a 50-50 Dr. Ronald Hass, Laboratory of Molecular Biolo­ gy, NIEHS, Research Triangle Park, N.C. " mark" its presence. chance of developing the disorder, an early 11/4 Dr. Jaap Goudsmit, Netherlands. Sponsor: But he had no idea which of 46 chromo­ diagnostic test will tell many of those who Dr. D. C. Gajdusek, NINCDS, Bg. 36, Rm. 5B25. somes carried the defective gene. Further, choose to be screened that the dread for 11/4- Dr. Andras Liptak, Hungary. Sponsor: Dr. the only way to test if a marker was near the themselves and their children is over. Josef Pitha, Laboratory of Cellular and Molecular Huntington's disease gene was to determine Others, however, probably brothers and Biology, NIA, GRC, Rm. 4B17. if the marker and the gene '"traveled" togeth­ sisters of those who escape, will learn that at 11/ 7- Dr.Hans Westerhoff, Netherlands. Spon­ er through a large family afflicted with the some time in their future, the disease is cer­ sor: Dr. Terrel Hill, Laboratory of Molecular Biolo­ disorder. tain to begin. This makes the need even more gy. NIADDK, Bg. 2, Rm . 317. 11/13 Dr. Shoichi Koizumi, Japan. Sponsor: Dr. '"The more people known in the family tree urgent to find adequate treatments. Bruce Chabner, Clinical Pharmacology Branch, and the more living offspring you have, the " Identifying the gene is still a problem," Dr. NCI, Bg. 10, Rm. 12C214. g reater the power of such a test," Dr. Wexler Wexler said. ··we can walk up and down the 11/13- Dr. Nicholaos C. Tassopoulos, Greece. said. chromosome and pass right by the Hunting­ Sponsor: Dr. Robert T. Purcell. Laboratory of In­ The needed scientific information came ton's d isease gene without knowing it. " fectious Diseases, NIAID. Bg. 7, Rm . 202 from a U.S. family identified through the The recombinant DNA methods used by 11/13-Dr. Luca Steardo, Italy, Sponsor: Dr. Huntington's Disease Research Roster and these investigators should also help scien­ Thomas N, Chase, Experimental Therapeutics from a family living in a stilt village built over tists who are studying other disorders. Branch, NINCDS, Bg. 10, Rm _ 5C103. Lake Maracaibo in Venezuela. The Venezue­ "The d iscovery of the marker is extraordi­ 11 /14-Dr. Paturu Kondaiah, India. Sponsor: Dr lan community has one of the highest rates of narily encouraging for anyone concerned Mario A. Anzano, Laboratory of Chemopreven­ tion, NCI, Bg 41 , Rm . D228. Huntington's d isease in the world. with hereditary disese," Dr. Wexler said. "The 11 /15- Dr. Feng Pei, China. Sponsor: Dr.Kevin An international team of investigators from techniques developed to find the marker J. Catt, Endocrinology and Re production Re­ different institutions in the United States and have advanced the field so much that other search Branch, NICHD, Bg. 10, Rm. 8C404. Venezuela, led by Dr. Wexler, constructed a people studying other inherited d isorders 11/18-Dr. Ester Zylber-Katz, Israel. Sponsor: family tree of more than 3,000 descendants won't have to start where we started. They'll Dr. Phillip Gorden, Diabetes Branch, NIADDK, of one Venezuelan woman villager who died be ahead of the game." Bg. 10, Rm . 9N222. of Huntington's disease more than a century "With these new techniques," Dr. Gusella 11 /21- 0r. lgal Kedar, Israel Sponsor: Dr.Phillip ago. Dr. Conneally logged the data into a added, " we can aim directly for the gene it­ Gordon, Diabetes Branch, NIADOK, Bg. 10, Rm. computer which used 100 feet of paper to self, the ultimate first cause, and try·to cor­ 9N222. print out the family tree. rect the problem at its root." - Lynn Cave D

December 6, 1983 The NIH Record Page 7 NCI Signs Agreement With Romanian Institute Dr. Yung-Pin Liu joins Grants Associate Program The National Cancer Institute signed a signing ceremony and reception for the dele­ Memorandum of Agreement on Oct. 31 with gation of Romanian scientists at Stone Dr. Yung-Pin Liu recently became the the Victor Babes Institute of Bucharest, House. 156th scientist selected to participate in the Romania. Professor Constantin Arseni, president of NIH Grants Associates Program, a 1-year This is the 10th such bilateral agreement in the Romanian Academy of Medical Sciences, program initiated in 1962 to train scientists as which the NCI is presently engaged. Other his wife Professor Niculina Arseni, and Dr. health science administrators. countries include the U.S.S.R., Hungary, loan Moraru, director of the Victor Babes In­ Most recently, Dr. China (Mainland), France, the Federal Re­ stitute in Bucharest and chairman of the dele­ ,Liu transferred from public of Germany, Japan, Italy, Poland, and gation, participated. the Department of Egypt. Other members of the Romanian delega­ Hematology at the The Memorandum of Agreement entered tion were Dr. Eugen Carasevici, lecturer, In­ Walter Reed Army into last month would not have been possible stitute for Medicine and Pharmacy, Institute of Re­ were it not for the Dec. 13, 1974, agreement, Bucharest; Dr. Liliana-Livia Georgian, senior search. Before that, signed in Bucharest, between the Govern­ research fellow, Victor Babes Institute, he was associated ments of the United States and Romania on Bucharest; and Dr. Andrei Sulica, head, de­ with the National Cooperation and Exchanges in the Cultural, partment of immunology, Victor Babes Insti­ Eye Institute and Educational, Scientific and Technological tute, Bucharest. the National Cancer Fields. This agreement has been extended Subject to the availability of funds and per­ Institute, an assist­ every 2 years since 1974. sonnel, NCI and the Victor Babes Institute ant professor at the His Excellency Mirchea Malitza, Ambassa­ agree that priority will be given to research in University of Ten- Dr. Liu dor to the United States from the Socialist Re­ cancer pathology, experimental pathology, nessee, research associate with St. Judes public of Romania, and Dumitro Neagu, third molecular genetics, and clinical studies of di­ Children's Research Hospital and Yale Secretary of the Embassy, attended the agnostic procedures. D University. His undergraduate work was done in Taiwan, where he received his B.S. degree in Over 900 Employees Have Received DELPRO Training chemical engineering. He received his M.S. tern through DCRT's user guide. Learning ob­ degree in physical chemistry from Lowell jectives were then established and an in­ Technological Institute, Lowell, Mass. and his structional strategy and sequence of learning Ph.D. in biochemistry from Baylor University, developed. Dallas. Over 100 pages of text were written, in­ Dr. Liu is the author of more than 50 arti­ cluding lessons, desk references, and a cles and abstracts and has received many troubleshooting guide. After a pilot course honors and other special recognitions. was conducted with the NCI Division of Can­ Among these are: cer Treatment, BIDs were scheduled for Recipient of the 1979 Fight for Sight Cita­ training as their term inals were installed. By tion of the Fight for Sight, Inc. for Outstand­ May 1983 over 900 people were trained on ing Achievement in basic research; awardee, DELPRO. Wadley Institute of Molecular Medicine Fel­ Ninety percent of the course is conducted lowship; awardee, Lowell Technological Insti­ at the terminal. Students work at their own tute Fellowship; and NIH Outstanding Super­ pace, following a series of lessons. An in­ visor of Summer Employees. structor is available for assistance. After His societies include the American Society completing the first several lessons, students of Biological Chemists, the Association tor Reginaii:t Russell, Printing and Reproduction start using desk aids. Research in Vision and Ophthalmology and Branch, is learning the DELPRO system. The desk aids are written protocols which the Chinese Biochemical Society. D can be used after training. Employees use In less than 2 years over 900 employees the desk aids to perform operational se­ have been trained to operale DELPRO, the quences, select options actions, and answer NIH delegated procurement system. The their own questions. This instructional ap­ training is a new endeavor for the Office of proach minimizes reliance on memory while the Assistant Director for Development and at the same time promotes independent Training, Division of Personnel Mana'gement. learning. The training office was asked to prepare em­ Now that DELPRO is used throughout NIH, ployees for the installation of DELPRO training is scheduled periodically for new em­ throughout NIH. ployees and nominations can be made Through DELPRO, a subsystem of the through administrative officers. D Administrative Data Base, personnel enter and manage their own delegated procure­ ments. Ordering, receiving, and paying are Computer Club To Hold Boots, Fair now automated. DELPRO, designed by the Division of Com­ The R&W Personal Computer Club will spon­ puter Research and Technology along with sor a book fair Tuesday, Dec. 13 in Wilson Hall, the Divisions of Administrative Services and Bldg. 1, complete with door prizes. Financial Management, has produced nu­ Books for beginners-to-experts in computing, merous benefits for NIH, most notably programming, and applications will be on quicker payment of bills and reduced display from 10:30 a.m. to 3 p.m. Exhibitors at­ paperwork. tending will include B. Dalton, Walden Books, Designing the training for DELPRO posed a Students, Res.Ion, and Computer Science Dr. Jacob Robbins, chief, Clinical Endocrinol­ challenge since there are no established pro­ Press. You may browse and place orders for ogy Branch, NIADDK, has received the Distin­ cedures for teaching computerized work sys­ yourself and holiday gifts. guish ad Service Award of the American Thy­ tems. The training, conducted for the past 2 In addition, from 12 to 1 p.m.. publisher Philip roid Association at their annual meeting In years, was designed in one month. Menzies and author Diane Martin will speak New Orleans. This award, the highest pre­ The course designers, Janean McKay and and answer questions from the audience on sented by the association, Is for leadership Milt Tipperman, learned to operate the sys- how to get published in the computer field. D and contributions to the field.

Page 8 The NIH Record December 6, 1983 Dr. Irwin Kopin Awarded Dr. Joseph F. Saunders Retires From NCI Anna Monika Prize After 31 Years of Federal Service Dr. Irwin J. Kopin, d irector of the Intramural " Fantastic, fascinating, exciting, Research Program, National Institute of Neu­ challenging, rewarding." rological and Communicative Disorders and With these words, Dr. Joseph F. Saunders, Stroke, recently received the 1983 Anna acting director of the NCI Office of Interna­ Monika Foundation prize for studies tional Activities, described the projects he investigating the bi­ worked on during 31 years of Federal serv­ ological bases of ice. manic-depressive Recently retired, Dr. Saunders has, since disorders. 1973, directed four activities of the Office of Formerly at the International Activities. He has been opera­ National Institute of tions manager for the international cancer re­ Mental Health, Dr. search data bank program; manager of the Kopin's prize­ USA-Hungary cooperative cancer research winning work was program: manager of the USA-People's Re­ accomplished dur­ public of China cancer program; and man­ ing his years with ager of the USA-USSR cooperative cancer that institution. His research program. team's research ef- " I am gratified to have been a part of the fort c larified Dr. Kopin international cancer research community," sources of a key neurotransmitter metabolite, said Dr. Saunders. "One of the most exciting MHPG, in cerebrospinal fluid, plasma, and events in the U.S.-Soviet exchange was the Dr. Saunders urine. recent d iscovery of human T-cell leuke­ MHPG (3-methoxy-4-hydrophenylglycol) is mia/lymphoma virus antigen in the sera of and 17 spaceflights. a byproduct of the metabolic breakdown of several baboons from a primate colony lo­ While working at the Office of Naval Re­ the neurotransmitter norepinephrine. Scien­ cated on the Black Sea at Sukhumi. search at the Navy Department in Washing­ tists had previously believed that MHPG "The USSR sent several of the baboons to ton, D.C., from 1952 to 1964, Dr. Saunders found in spinal fluid reflected mostly brain NCI some 8 years ago, originally to examine received the Arthur S. Flemming Award for norepinephrine activity. them for viruses that might be directly or indi­ Outstanding Federal Service for management Ors. Kopin and colleagues David Jimerson, rectly associated with cancer. We d id not an- of a program for the long-term preservation Sanford Markey, Michael Ebert and Ronald ticipate this finding." • of human whole blood. Polinsky have now shown that, in fact, cere­ The animals are now being stud ied in Dr. The system was adapted and used by the brospinal fluid MHPG includes a large contri­ Robert Gallo's laboratory at NCI. Information British Army Medical Services and the bution from blood. They have derived a new on them has been transmitted to Dr. Boris Netherlands Red Cross. It was later modified formula for determining MHPG derived from Lapin, the Soviet scientist who first discov­ for use in Vietnam. the central nervous system MHPG. ered the lymphomas in this primate colony. During the early 1960s, Dr. Saunders col­ Nor epinephrine Secretions Dr. Saunders was chief of biology pro­ laborated with Dr. C. Gordon Zubrod, then grams at NASA's Office of Manned with NCI, on a preservation process for Much MHPG in blood comes from Spaceflight from 1971 to 1973, and manager leukocytes and platelets used in cancer norepinephrine released by the peripheral of Apollo Program bioscience experiments treatment. nerves. These secretions are indirectly stimu­ from 1972 to 1973. Dr. Saunders has received many awards lated by the brain in response to stress. Clini­ At a European space research meeting in d uring his c areer, including the DHHS Spe­ cal investigators have used changes in Paris in 1971, he learned of a radiation ex­ c ial Achievement Award in 1982, and the NIH MHPG levels in body fluids to help distin­ periment under way at the University of Director's Award in 1979. After a 6-week guish different types of depression. Frankfurt. Through his efforts, BIOSTACK, as vacation, he will begin a new career as depu­ Dr. Kopin's team determined that blood it was named, became the first basic ty to the executive officer.of the American MHPG accounts for most of the body's bioscience experiment to fly on the Apollo 16 Physiological Society in Rockville. D norepinephrine production and that only about 20 percent of MHPG in urine is derived from the brain. Dr. Levine Delivers Karon Memorial Lecture Blood MHPG levels are thus substantially dependent on psychiatric state and are re­ Dr. Arthur S. Levine, Scientific Director of own laboratory, published in the October is­ lated to heritable traits. the National Institute of Child Health and Hu­ sue of the Proceedings of the National Acad­ Also blood MHPG levels are correlated man Development, delivered the Ninth Annu­ emy ot Sciences, that reflects this theme. with abnormal neurohormone responses al Myron Karon Memorial Lecture Nov. 18 at As NICHD Scientific Director, Dr. Levine commonly found in depressed patients. The the Childrens Hospital of Los Angeles, Uni­ heads a broad program of basic and c linical­ findings open up new lines of investigation versity of Southern California School of ly applied research in the area of develop­ for relating MHPG to stress, anxiety, diet and Medicine. mental biology. Prior to assuming his present other factors in psychiatric illness. Dr. Levine's lecture was entitled, " From position in 1982, Dr. Levine had spent his The Anna Monika Prize is awarded for re­ Fruit Flies to One Genes: What Developmen­ earlier career in the NCI where he had been search advancing knowledge about biologi· tal Biology Offers to Cancer Research." In his chief of the Pediatric Oncology Branch. cal bases of mental illness. This year's lecture, Dr. Levine pointed out that we have Dr. Levine has been widely honored for his awards were presented at a ceremony in St. no "theory" of developmental biology nor of achievements in basic and clinical research. Moritz, Switzerland. □ oncognenesis in the same sense that we In October, he delivered the Annual Max have theories of evolution and genetics, but Seham Lectureship in Minneapolis. Photography Section Moving that these two areas of research are present­ The Karon Memorial Lecture was estab­ ly running in parallel. lished to honor Dr. Myron Karon, who in the The Photography Section of the Medical Arts This parallelism has been given much im­ early 1960s had been a senior investigator in and Photography Branch is in the process of petus by the recent discovery of one genes, the NCI Medicine Branch. Dr. Karon, together moving to Rm. B2L321, Bldg. 10. The phone which may have an important normal role in with his colleagues, Ors. Emil Freireich and number for general photography will remain regulation of the cell cycle, cell growth and Emil Frei, made pioneering contributions to the same, 4496-5595; photomicrography, d ifferentiation, as well as their more widely the treatment of childhood leukemia, as well 496-2193; and photomacrography, studied role in malignant transformation. as to our knowledge of the molecular biology 496-2329. □ He also described recent work from his of cancer cells. □

December 6, 1983 T he NIH Record Page 9 10, 1983 to Aug. 9, 1984. Eleven FIC Scholars Doing Dr. Le Thi Bich-Thuy from INSEAM U 80, Tetanus Shot to Mother Research in Federal Labs Paris, will work under Dr. Anthony S. Fauci at Immunizes Unborn Baby NIAID on a research project entitled " Regula­ In FY 1983, the Fogarty International Cen­ tions of Antigen-Specific Human B Cell Acti­ Researchers have shown for the first time ter awarded fellowships to 99 foreign scien­ vation." Fellowship period: Nov. 1, 1983 to that pregnant mothers who are vaccinated tists to conduct collaborative research in U.S. Oct. 31, 1984. against tetanus pass their immunity on to institutions. including the NIH Intramural Dr. Jung Bock Lee from Yonsei University, their babies Program. Korea, will work under Dr. Stuart T. Brown at A research team led by Dr. Thomas J. Gill Eleven of these scientists will be con­ CDC on a research project entitled "Ad­ Il l of the University of Pittsburgh Medical ducting research in Federal laboratories. vanced Diagnostic Methods for Syphilis and School, supported with grants from the Na­ They are: Other STD." Fellowship period: Apr. 15, 1983 tional Institute of Child Health and Human Dr. Sandro Betocchi, from the University to Apr. 14, 1984. Development, found that the tetanus vac­ of Naples in Italy, will work under Or. Douglas Dr. Tore Lindmo, from Norsk Hydro's Insti­ cine- given to women in the later months of R. Rosing at NHLBI on a research project en­ tute in Oslo, Norway, will work under Paul A. pregnancy- crosses the placenta and enters titled " Pathophysiology of Hypertrophic Bunn, Jr., at NCI on a research pro1ect enti­ the fetal blood stream. The protection in the Cardiomyopathies." Fellowship period: Aug. tled "Variability in Expression of Tumor Asso­ child was found to last longer than 1 year. 24, 1983 to Aug. 23, 1984. ciated Antigens." Fellowship period: July 23, According to Dr. Delbert H. Dayton, chief Dr. Robet I. Craggs, from the Royal Free 1983toJuly22, 1984. of the Genetics and Teratology Section of Hospital School of Medicine, London, will Dr. Orjan Olsvik, from the Norwegian NICHD's Center for Research for Mothers work under Dr. Henry deforest Webster at College of Veterinary Medicine in Oslo, will and Children, the discovery will benefit fami­ NINCDS on a research project entitled work under Or. John C. Feeley at CDC on a lies in rural areas of the United States and in " Neuritogenic Factors in Experimental Aller­ research project entitled " Toxins from Staph­ developing countries where newborn care is gic Neuritis." Fellowship period: Sept. 1, ylococci causing Toxic Shock Syndrome." not available or vaccination programs may 1983 to Aug. 31, 1984. Fellowship period: Sept. 28, 1983 to Sept. 27, be difficult to carry out. Dr. Anne Marie Duchemin, from St. 1984. Dr. Dayton believes that future prenatal im­ Anne's Hospital in Paris, will work under Dr. Dr. Gerhard Skofitsch, from the University munization may also become possible Richard J. Wyatt at NIMH on a research proj­ of Graz, Austria, will work under Dr. David against streptococcal infections and ect entitled "Endogenous Neuroleptic-Like Jacobowitz at NIMH on a research project meningitis. Substance in the Human Brain." Fellowship entitled " Neuropeptides." Fellowship period: Immunity Passed On period: July 1, 1983 to June 30, 1984. Aug. 29, 198310 Aug. 28, 1984. Dr. Klaus P. Hedman, from the University Dr. Gertraud Wasner, from the Austrian "It has long been known that a mother's of Helsinki, Finland, will work under Dr. Ira Academy of Sciences, Vienna, will work un­ antibodies can cross the placenta into the Pastan at NCI on a research project entitled der Dr. Brad E Thompson at NC I on a re­ baby," Or. Gill said. "What we discovered in " Genesis of and Growth Stimulation by Peri­ search project entitled " Properties of Human this study is that the tetanus toxoid can cross cellular Matrix." Fellowship period: Nov. 1. Mutant Glucocorticoid Receptors." Fellow­ the barrier so that the child can make its own 1983 to Oct. 31, 1984. ship period: Aug. 1, 1983 to June 30, 1984. antibodies." Parenthetically, Dr. Gill pointed Dr. Ja-Hyun Koo, from Han Yang Universi­ FIC's International Research Fellowship out that he and his colleagues had found in ty in Seoul, Korea, will work under Dr. Sue­ Program was established in 1958 and pres­ earlier animal studies that immunity in rats Goo Rhee at NHLBI on a research project en­ ently 50 countries throughout the world par­ can be passed on even into the second gen­ titled " Studies on Adenylyltransferase in ticipate. Since 1958, 2,139 fellowships have eration because the pups' pups were found Escherichia Coli." Fellowship period: Aug. been awarded. D to have gained immunity from one single in­ jection to the grandmother. Three years ago following extensive exper­ Department Now Accepting Payments imentation with pregnant rats, Dr. Gill re­ Help for Federal Employees ceived permission to test the transplacental In Choosing Health Plan For Post-1956 Military Service Deposits tetanus immunization on 42 pregnant women. After birth, the infants of these mothers were NIH employees were notified in the June 7, You may be able to save several hundred found to have protection against tetanus in 1983 issue of the NIH Record on how to pay 7 their blood whereas the newborns of 25 dollars on next year's insurance premiums and percent of the basic military pay they received medical bills by choosing the best health insur­ unimmunized control mothers did not. for post-1956 military service to avoid cuts in The immunized infants also responded ance plan for your needs during Nov. 14 their civil service annuities when they become through Dec. 9, when government employees more rapidly than the others to DPT immuni­ eligible for Social Security at age 62 or later. zation (Diphtheria, Pertussis, Tetanus) and have their annual "Open Season" opportunity They were reminded to send their military for switching plans. they still had a high level of tetanus antibod­ discharge form 00-21 4 or equivalent to the mil­ ies 13 months after birth. Every Federal employee has more than 15 itary pay center of the branch they served in to Dr. Gill said he chose the tetanus vaccine plans to choose from, but many employees are request an estimate of basic military earnings, for this research because it is one of the unaware of some of the plans where coverage and that they would be notified when proce­ is excellent and costs are very low. The tables safest, having been used in humans for over dures for making this deposit were completed. 50 years. Women were vaccinated at 6 and 8 in this book show total medical expenses in­ HHS will now accept lump sum payments or months into pregnancy because after 5 cluding both premiums and out-of-pocket costs monthly payments of no less than $50. Retiring months the major development of the fetal or­ under each plan. employees must complete deposits prior to re­ gans has been completed so that any malfor­ The tables show what each plan will cost in tirement and survivors of employees who die in mations would be improbable. Dr. Gill said an "average" year and in years in which your service must complete deposits when making that all infants of the immunized mothers costs are much better or worse than average. application for survivor annuity. This book also provides data on customer serv­ were born healthy and generally remained so Employees planning for retirement are ad­ during the 3-year study. ice under many of the plans- for in­ vised to hold and retain the amount of the de­ stance-which ones pay their bills promptly Dr. Sumner J. Yaffe, director of the NICHD posit until Oct. 1, 1985 (or retirement, if sooner) Center for Research for Mothers and Children and without red tape. since deposits are interest free until that date. Pick up a copy at any R&W Gift Shop or the which monitored Dr. Gill's research, called Those interested in making this deposit should the successful transplacental immunization Activities Center, Bldg. 31. Price per copy is contact their Personnel Ottice for necessary $4.50 (regular price $4.95). D highly significant but warned that further forms and for further details. D long-term studies on the safety and effective­ People occasionally stumble over the truth, ness of the vaccination with tetanus and but most of them pick themselves up and It would be a very fine thing for the world if other toxoids were needed before large­ hurry off as if nothing had happened. everyone were entitled, in some slight de­ scale adoption would be possible. D -Winston Churchill □ gree, to be lucky.- E.B. White □

Page 10 The NIH Record December 6, 1983 Ors. Frank and Froehlich Selected for SES Program Kidney Stones Prevention And Treatment Described

Each year. more than a million Ameri­ cans- typically white, middle-aged men-are hospitalized for treatment of kid­ ney (also known as "urinary") and bladder stones. The stones are hard masses that gradually build up when various salt or mineral crystals deposit on the inner surfaces of the kidney. As the stones grow larger, bleeding may oc­ cur. Or stones may be passed during urina­ tion, causing severe pain in the back, side and groin. In the past, little could be done for most patients with kidney stones. Now kidney stones- especially those that recur-are considered a preventable disease, accord­ ing to research supported by the National In­ Dr. Froehlich Dr. Frank stitute of Arthritis, Diabetes, and Digestive and Kidney Diseases. Two NIH employees, Ors. Martin Frank, still serves as an associate professorial lec­ The results of this research have been DRG. and Luz A. Froehlich, NIAID. have been turer at GWU and is a member of the research summarized in a recently-issued brochure ti­ notified by HHS Secretary Heckler that they committee of the American Heart Associa­ tled " Prevention and Treatment of Kidney are among 22 candidates selected to partici­ tion, Nation's Capital Affiliate. Stones." The brochure notes that the causes pate in the Departmental Senior Executive After receiving his Ph.D. in physiology from of this ancient health problem (evidence of Service Candidate Development Program. the University of Illinois in 1973, Dr. Frank be­ stones has been found in an Egyptian mum­ The SES Program is designed to provide came research associate at Michigan Cancer my dating from about 4,800 B.C.) may in­ outstanding women and men with a variety of Foundation, Detroit, and Michigan State Uni­ clude age, genetic defects, occupation, cli­ developmental experiences to prepare them versity, East Lansing. mate, and drinking too little fl uid, which can for senior management positions within 2 Dr. Froehlich, who joined NIAlp in 1971 , decrease the amount of urine and increase years. was recently appointed deputy director of the concentration of elements, such as calci­ The program offers participants a unique NIAID's Extramural Activities Program. In ad­ um, that form stones. opportunity to broaden their career perspec­ dition to her new role, she remains as chief of A variety of health problems can also tive and develop executive skills. Candidates the lnstitute's Program and Project Review cause kidney stones, including recurring uri­ remain in their current positions while Branch. nary tract infections, misuse of certain medi­ completing temporary assignments and for­ A board-certified pathologist, Dr. Froehlich cations, metabolic disorders (such as gout), mal course work. was born in the Philippines, graduating with overactive parathyroid gland, and chronic in­ Since 1978, Dr. Frank has been executive high honors from the University of the Philip­ flammation of the bowel. Stones also tend to secretary of the Physiology Study Section, pines' College of Liberal Arts. ln 1953, she form in people who have had an intestinal one of approximately 75 study sections within earned the M.D. degree from the University's bypass operation or blockage of the urinary the Division of Research Grants whose mem­ College of Medicine. tract. bers evaluate the scientific and technical Her diversified skills in science and admin­ While diet may cause stones to form in sus­ merit of investigator-initiated research appli­ istration earned her the 1976 NIH Director's ceptible people, scientists do not believe that cations in the first level of peer review at NIH. Award for "Effective administration of spe­ eating any specific food causes them to form Before coming to NIH, Dr. Frank was as­ cialized NIAlD grants programs and for en­ in healthy individuals. sistant professor of physiology at the George thusiastic and productive participation in NIH The brochure describes the symptoms of Washington University Medical School. He efforts in Equal Employment Opportunities." D kidney stones, and how physicians diagnose, treat, and prevent them. For example, a new nonsurgical treatment uses high-energy Dr. Robert Gallo To Deliver Alexander Capron Will Lecture acoustic shock waves to shatter kidney Dyer Lecture on Viruses On Genetic Engineering, Dec. 19 stones. The patient is anesthetized and posi­ tioned in a water bath so that the highest en­ The 1983 R. E. Dyer Lecture will be pre­ The Foundation for Advanced Education in ergy of the shock wave is precisely aimed at sented by Dr. Robert C. Gallo, chief of the Na­ the Sciences will sponsor a lecture on Genetic the kidney stone and does not harm any tional Cancer lnstitute's Laboratory of Tumor Engineering in Human Beings, presented by other area of the body. Cell Biology, on Wednesday, Dec. 14, at 8: 15 Alexander Capron on Monday, Dec. 19, at 4 Treatment for kidney stones must be tai­ p.m .. in Masur Auditorium. The title of the lec­ p.m. in Wilson Hall, Shannon Bldg. lored to the individual and to the specific ture is " Human Tumor Viruses: The Search for Mr. Capron, professor of law, ethics and pub­ cause of the stone. Increasing the daily con­ Some is Over." lic policy at Georgetown University Law Center, sumption of liquids, mainly water, is a good Dr. Gallo will discuss the search for the first was executive director of the President's Com­ way to prevent kidney stones. human RNA tumor virus, or retrovirus, known as mission for the Study of Ethical Problems in For copies of "Prevention and Treatment of HTLV (human T-cell leukemia virus); its strong Medicine and Biomedical and Behavioral Re­ Kidney Stones," write to "Kidney Stones," association with a rare form of T-cell leukemia­ search. Experienced in this field, he is particu­ National lnstiute of Arthritis, Diabetes, and lymphoma in adults, and its similarity to a virus larly interested in problems presented by re­ Digestive and Kidney Diseases, Bldg. 31, that appears to be causally linked with ac­ cent advances in molecular and medical Rm. 9A04, Bethesda, MD 20205; or call (301) quired immune deficiency syndrome, or AIDS. genetics. 496-3583.-Maureen Mylander D The Dyer Lecture was established in 1950 to A reception will follow the lecture. For further honor former NIH Director Rolla E. Dyer. The information, contact Dr Alan Schechter, chair­ lectureship is awarded annually to scientists man, FAES Lecture Series, 496-5408. D Nothing knits man to man like the frequent who have made an outstanding contribution to passage from hand to hand of cash.-Walter knowledge in a field of medical science. □ S,ckert □

December 6, 1983 The NIH Record Page 11 More Research Needed on Fragile X Syndrome Ten recommendations to help guide re­ l ive figures place its frequency at about half search on a chromosomal defect called the the Down syndrome rate. fragile X syndrome were recently compiled The name, fragile X, refers to the genetic by a panel of 22 experts from four continents problem that causes the d isorder: a weak­ meeting at NIH. ening, constriction or defect on the X chro­ The 2-day workshop, sponsored by mosome. The X chromosome is one of the NICHD's Mental Retardation and Develop­ two sex-determining bundles of gentic mate­ mental Disabilities Branch, brought together rial in human cells. Male cells contain one X scientists working on fragile X to discuss the and one Y, while female cells carry two Xs. state of the science, identify gaps in knowl­ Although researchers still don't understand edge and determine potential research the fragile X syndrome, they do agree on its strategies. outward signs. They caution, however, that Fragile X is an elusive genetic abnormality characteristics typical of the syndrome do that scientists think may account for 25 per­ not g uarantee that the fragile X chromosome cent of all sex-linked mental retardation in is present. They also note that generally there men. Its prevalence was not recognized until are no visible physical signs of fragile X at recently. birth. To help guide the developing body of During the workshop, scientists described fragile X knowledge, the panel's recommen­ the general traits in males as mild to severe dations included: mental retardation, increased head circum­ • more research involving family members ference, long facial features with prominent to help explain why fragile X tends to appear jaw and loreheard and large ears, speech in certain families; and hearing deficiencies, poor motor skills, • guidelines to clearly define the physical abnormal behavior and hyperactivity. The and behavioral traits; most common sign is macroorchidism, that • establishment of DNA and cell banks for is, testicles three to four times larger than future research: normal. • application of recombinant DNA Some female carriers are slightly retarded methods; and may have some of the general traits • more studies on culturing techniques; found in men. • more research aimed at prenatal diagno­ Cochairing the meeting were Ors. Park S. sis ol the condition. Gerald, professor of pediatrics at Harvard Of the hundreds of causes of mental retar­ Medical School and Herbert A. Lubs, director dation, researchers consider fragile X sec­ of the division of genetics at the University of ond only to Down syndrome as a definable Miami (Fla.) School of Medicine. genetic reason for mental retardation in Dr. Lubs is credited with initiating interest males. in the fragile X syndrome when, as an NICHD Down syndrome occurs about once in ev­ grantee in 1969, he identified four men from ery 1,000 births. While estimates vary about the same family who had the defect. D the prevalence of fragile X, even conserva-

Dr. Andres Wins Kolker Award biomedical fields, but his special interests cen­ ter on glucose homeostasis, obesity and its re­ The Irving M. Kolker Award, presented annu­ lation to longevity, and longitudinal studies of ally for contributions in the fields of aging and human aging. aging research, was presented to Dr. Reubin A member of many professional societies Andres, clinical director of the National Institute and organizations, Dr. Andres has received nu­ on Aging, on Oct. 25. merous other awards. In 1974, he won the Last year's winner, Dr. Nathan W. Shock, NIH Kleemeier Award from the Gerontological Soci­ scientist emeritus, made the presentation. ety and, in 1978, the NIH Director's Award. D The award, given by the levindale Hebrew Geriatric Center and Hospital in Baltimore, em­ phasized Dr. Andres' "distinguished leader­ ship, career achievements, and dedication to HAPPY HOLIDAVS gerontology and geriatrics." At a dinner in his honor, Dr. Andres gave a lecture entitled, "True Confessions of an Aging Gerontologist." The title, he explained, was chosen to emphasize that current detailed Happy Holidays knowledge of biological aging processes in from the staff of man has come from an accelerating research the NIH Record. effort by many scientists in recent years. The next NIH Dr. Andres showed examples of several Record will be standard tests which must take age into ac­ published on Jan. count to avoid over-diagnosing common dis­ 3 , 1984 . □ ease states in middle-aged and elderly people. A professor with the department of medicine at the Johns Hopkins Institute, Dr. Andres as­ sumed the role of NIA clinical director in 1976. He has been chief of the lnstitute's Clinical Physiology Branch at the Gerontology Re­ search Center in Baltimore since 1969, and serves as assistant chief of the GRC. Dr. Andres' scientific interests span several U.S. GOVERNMENT PRINTING OFFICE 1983-381, 134/ 7

Page 12 The NIH Record December 6, 1983