Table S1 - The examined in this work and their classification.

Phylum Classification Ajellomyces, , Arthrobotrys oligospora, Orbiliales, Orbiliaceae Arthroderma (Trichophyton), Onygenales, Arthrodermataceae Aspergillus (Neosartorya), Eurotiales, Trichocomaceae Botryotinia fuckeliana, Helotiales, Sclerotiniaceae Ceratocystis, Ceratocystidaceae, Microascales Chaetomium, Sordariales, Chaetomiaceae , Onygenales, lunatus, , Cordyceps militaris, Hypocreales, Clavicipitaceae Fusarium (Gibberella, Nectria), Hypocreales, Nectriaceae Glomerella, Glomerellales, Glomerellaceae Leptosphaeria, Pleosporales, Leptosphaeriaceae Magnaporthe oryzae, Magnaporthales, Magnaporthaceae Metarhizium, Hypocreales, Clavicipitaceae Monacrosporium cionopagum, Orbiliales, Orbiliaceae Mycosphaerella graminicola, Capnodiales, Mycosphaerellaceae Neurospora crassa, Sordariales, Sordariaceae Penicillium (Talaromyces), Eurotiales, Trichocomaceae Podospora anserine, Polyporales, Fomitopsidaceae Pyrenophora, Pleosporales, Pleosporaceae Sclerotinia sclerotiorum, Helotiales, Sclerotiniaceae Sordaria macrospore, Sordariales, Sordariaceae Thielavia, Sordariales, Chaetomiaceae Trichoderma (Hypocrea), Hypocreales, Hypocreaceae Tuber melanosporum, Pezizales, Tuberaceae reesii, Onygenales, Onygenaceae Coprinopsis cinerea, ; Psathyrellaceae Laccaria bicolor, Agaricales, Hydnangiaceae Moniliophthora perniciosa, Agaricales, Marasmiaceae Postia placenta, Polyporales, Fomitopsidaceae Schizophyllum commune, Agaricales, Schizophyllaceae lacrymans, , Serpulaceae Taiwanofungus camphorates, Polyporales, Coriolaceae

Table S2 - Hydrophobicity of the putative amino acids from the sequences in group IV.

GenBank accession no. of the genes XM_001591342 CCD42656 XM_002372112 XM_003048347 AFQF01003174 AFQF01004521 GL985072 CP003006 XM_001227411 XM_955172.1 GL891307 XM_955170 XM_003042519 AFQF01003703 GL988040 CP003011 GL698514 GL698736

24 1.644 15 -0.278 18 2.156 20 1.256 20 0.522 19 0.900 22 1.333 19 0.489 19 0.922 21 0.900 20 1.267 20 1.189 33 -2.022 21 -0.911 19 0.356 20 0.367 155 0.056 32 0.400

25 1.133 16 -0.356 19 2.200 21 0.333 21 0.056 20 -0.022 23 1.233 20 -0.011 20 0.533 22 1.111 21 1.311 21 1.233 34 -1.622 22 -1.211 20 0.300 21 0.067 156 -0.722 33 -0.378

26 1.778 17 0.022 20 1.911 22 -0.178 22 -0.800 21 -0.533 24 0.811 21 -0.656 21 -0.111 23 0.333 22 0.889 22 0.811 35 -1.033 23 -0.511 21 0.300 22 -0.200 157 -0.722 34 -0.722

27 1.189 18 0.011 21 0.989 23 -0.178 23 -0.800 22 -0.244 25 1.189 22 -0.922 22 -0.667 24 -0.256 23 0.478 23 0.400 36 -0.611 24 -0.156 22 0.367 23 0.222 158 -1.022 35 -1.022

28 0.600 19 -0.578 22 0.744 24 -0.467 24 -1.044 23 -0.533 26 0.678 23 -1.511 23 -1.011 25 -0.556 24 0.189 24 0.156 37 -0.289 25 -0.244 23 -0.011 24 -0.156 159 -0.722 36 -1.300

29 0.311 20 -0.578 23 0.467 25 -0.422 25 -1.089 24 -0.578 27 0.689 24 -0.911 24 -0.411 26 -0.656 25 -0.400 25 -0.433 38 -0.256 26 -0.211 24 -0.567 25 -0.711 160 -1.089 37 -1.667

30 0.700 21 -0.022 24 0.500 26 -0.333 26 -0.711 25 -0.578 28 0.956 25 -0.978 25 -0.978 27 -1.244 26 -0.667 26 -0.989 39 -0.556 27 -0.556 25 -0.522 26 -1.011 161 -1.633 38 -2.211

31 1.289 22 0.533 25 0.200 27 -0.633 27 -1.222 26 -1.089 29 0.667 26 -0.567 26 -0.567 28 -1.244 27 -0.667 27 -0.911 40 -0.311 28 -0.600 26 -0.567 27 -0.600 162 -1.056 39 -1.633

32 1.000 23 0.522 26 0.333 28 -0.922 28 -0.544 27 -0.411 30 0.700 27 -0.611 27 -0.611 29 -1.800 28 -0.289 28 -0.778 41 0.078 29 -0.667 27 -0.633 28 -0.667 163 -0.978 40 -1.556

33 1.000 24 1.411 27 0.367 29 -0.278 29 -0.122 28 0.011 31 0.200 28 -1.200 28 -1.200 30 -1.256 29 0.389 29 -0.100 42 -0.478 30 -1.222 28 -1.222 29 -1.222 164 -0.344 41 -0.922

34 1.011 25 0.911 28 -0.178 30 0.144 30 -0.256 29 0.333 32 0.200 29 -0.656 29 -0.622 31 -1.122 30 -0.156 30 -0.644 43 -0.467 31 -1.211 29 -1.211 30 -1.211 165 0.078 42 -0.500

35 0.367 26 0.533 29 -0.267 31 0.011 31 -0.222 30 -0.122 33 0.344 30 -0.522 30 -0.489 32 -0.300 31 0.167 31 -0.322 44 -0.756 32 -1.500 30 -1.500 31 -1.500 166 0.289 43 -0.289

36 0.100 27 0.267 30 -0.122 32 -0.256 32 -0.522 31 -0.122 34 -0.244 31 0.300 31 0.333 44 -0.767 32 0.311 32 -0.178 45 -0.178 33 -0.922 31 -0.956 32 -0.956 167 0.322 44 -0.256

37 0.100 28 0.267 31 -0.467 33 -0.556 33 -0.867 32 -0.422 35 -0.589 43 -0.767 46 -0.511 45 -0.433 33 0.011 33 -0.522 46 -0.044 34 -0.789 32 -0.822 33 -0.822 168 -0.567 45 -0.567

38 -0.200 29 -0.044 32 -0.778 34 -0.900 34 -0.922 33 -0.478 36 -0.656 44 -0.433 47 -0.522 46 -1.111 34 -0.033 34 -0.567 47 0.778 35 0.033 33 0.000 34 0.000 169 -0.567 46 -0.567

39 -0.200 30 -0.200 33 -0.878 35 -0.956 35 -1.211 34 -0.767 37 -1.211 45 -1.111 48 0.333 47 -0.811 35 -0.378 35 -0.622 59 -0.800 47 -0.767 45 -0.767 46 -0.767 170 -0.633 47 -0.633 hydrophobicity 40 -0.789 31 -0.756 34 -1.167 36 -1.244 36 -1.211 35 -0.767 38 -1.211 46 -0.511 49 0.444 48 -0.822 36 -0.967 36 -1.211 60 -0.467 48 -0.433 46 -0.433 47 -0.433 171 -1.222 48 -1.222 their

41 -0.789 32 -0.756 35 -1.211 37 -1.244 37 -1.800 36 -1.356 39 -1.800 47 -0.233 50 0.256 49 0.033 37 -1.256 37 -1.256 61 -1.111 49 -1.078 47 -1.078 48 -1.111 172 -1.211 49 -1.211

42 -1.344 33 -1.344 36 -1.800 38 -1.800 38 -1.222 37 -0.778 40 -1.256 48 0.622 51 -0.333 50 0.144 38 -1.844 38 -1.844 62 -1.111 50 -0.833 48 -1.078 49 -0.800 173 -1.500 50 -1.500

43 -0.767 34 -0.767 37 -1.256 39 -1.222 39 -1.089 38 -0.989 41 -1.122 49 0.733 52 -0.578 51 -0.044 39 -1.300 39 -1.300 63 -1.122 51 -0.844 49 -1.089 50 -0.811 174 -0.922 51 -0.922

44 -0.633 35 -0.633 38 -1.122 40 -1.089 40 -0.267 39 -0.022 42 -0.300 50 0.544 53 0.022 52 -0.633 40 -1.167 40 -1.167 64 -0.267 52 0.011 50 -0.233 51 0.044 175 -0.789 52 -0.789

45 0.189 36 0.189 39 -0.300 41 -0.267 52 -0.767 51 -0.767 54 0.089 51 -0.044 54 0.478 53 -0.878 41 -0.344 41 -0.344 65 -0.156 53 0.122 51 -0.122 52 0.156 176 0.033 53 0.033

57 -0.122 48 -0.122 51 -0.767 53 -0.767 53 -0.433 52 -0.433 55 -0.433 52 -0.289 55 0.733 54 -0.278 56 -0.233 47 1.222 66 -0.344 54 -0.100 52 -0.344 53 -0.033 188 -0.767 65 -0.767 Number ofthe putative and amino acids 58 -0.433 49 -0.433 52 -0.433 54 -0.433 54 -1.111 53 -1.111 56 -1.111 53 0.311 56 0.322 55 0.178 57 -0.533 48 1.256 67 -0.622 55 -0.689 53 -0.933 54 -0.622 189 -0.433 66 -0.433

59 -1.111 50 -1.111 53 -1.111 55 -1.111 55 -0.767 54 -1.111 57 -0.811 54 0.767 56 0.733 58 0.322 49 0.911 68 -0.867 56 -0.933 54 -1.178 55 -0.867 190 -1.111 67 -1.111

60 -0.811 51 -0.811 54 -0.811 56 -0.767 56 -0.778 55 -0.611 58 -0.911 55 1.022 57 0.433 59 0.433 50 -0.056 69 -0.267 57 -0.333 55 -0.578 56 -0.267 191 -1.111 68 -1.111

61 -0.822 52 -0.822 55 -0.533 57 -0.778 57 0.078 56 0.244 59 -0.700 56 0.322 60 0.244 51 -0.011 70 0.189 58 0.122 56 -0.122 57 0.189 192 -1.122 69 -1.122

62 -0.611 53 -0.611 56 0.322 58 0.078 58 0.189 57 0.700 60 -0.589 61 -0.344 52 0.233 71 1.078 59 0.733 57 0.733 58 0.733 193 -0.267 70 -0.267

63 -0.500 54 -0.500 57 0.433 59 0.189 59 0.000 58 0.511 61 -0.778 62 -0.589 53 -0.189 72 1.367 60 1.022 58 0.389 59 0.733 194 -0.156 71 -0.156

64 -0.689 55 -0.689 58 0.244 60 0.000 60 -0.589 59 -0.078 62 -1.367 63 0.011 54 0.144 195 -0.344 72 -0.344

65 -0.933 56 -0.933 59 -0.344 61 -0.589 61 -0.833 60 -0.322 63 -1.611 64 0.467 55 -0.533 196 -0.933 73 -0.933

66 -0.589 57 -1.178 60 -0.589 62 -0.833 62 -0.233 61 0.278 64 -1.089 65 1.022 56 -0.233 197 -1.178 74 -1.178

67 -0.567 58 -1.156 61 0.011 63 -0.233 63 0.222 62 0.733 65 -0.633 66 0.322 57 -0.533 198 -0.578 75 -0.578

68 -0.178 59 -0.767 62 0.467 64 0.222 64 0.733 63 1.622 66 -0.078 58 0.322 199 -0.122 76 -0.122

69 0.189 60 -0.400 63 1.022 65 0.733 65 0.389 64 0.811 67 -0.289 59 0.433 200 0.733 77 0.733

70 0.744 61 0.156 64 0.389 66 0.389 60 0.244 201 0.733 78 0.733

71 0.422 62 -0.100 61 -0.344 Table S3 - The secondary structure and surface-interior prediction of the putative amino acids of the sequences in group IV. B, buried; E, extended; H, helical.

GenBank accesstion no. The secondary structure and burial prediction of the putative amino acids Number of the putative amino acids

1------11------21------31------41------51------61------71 XM_001591342 Jnet ---HHHHHHHHHHHHHHHHHHHHHH------EEEE------EEEEEEEE------24-45, 57-71 Jnet_25 ---B--BBBBBBBBB-BBBBBBBBBBBB--B---BBBBBB--BB-BBBBBBB-B-B-BBBBBB-B--B-B-

1------11------21------31------41------51------61- CCD42656 Jnet ------E----EEEEE------EE------E------15-36, 48-62 Jnet_25 -B----B-BBBBBBBBBBBBB--BBBBBB--B-BB--B--BBBBBBB-BBBBBB-BB-BB---

1------11------21------31------41------51------61--- XM_002372112 Jnet --HHHHHHHHHHHHHHHH------EEEEEEE---EEE------E 18-39, 51-64 Jnet_25 ----BBBBBBBBBBBBBB-BB-B-----B-BBBB--BB-BBBBBBBBB-B-BBBBBB--B-B--B

1------11------21------31------41------51------61----- XM_003048347 Jnet ----HHHHHHHHH------EEEEEE------EEEEEE------E 20-41, 53-66 Jnet_25 ----BBBBB-BBBBBB------B--B-BBBB-B--BB-BBBBBBBBB-B-BBBBBB----B--

1------11------21------31------41------51------61---- AFQF01003174 Jnet ----HHHHHH------EEEE------EEEEEEEE---EEE------E 20-40, 52-65 Jnet_25 ----BB-BB-BB---BB----B------BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B--B

1------11------21------31------41------51------61--- AFQF01004521 Jnet ---HHHHHHHHHHHHHH------EEEE------EEEEEE------E 19-39, 51-64 Jnet_25 ---BBBB-BBBBBBBB-BB-B------BBBBBB--BB--BBBBBBBBBB-BBBBBB--B-B--B

1------11------21------31------41------51------61----- GL985072 Jnet ---HHHHHHHHHHHHH------E------EEEE------EEEEEEEE------22-42, 54-67 Jnet_25 ---B--BBBBBBBBBBB---BBBBBB-B---BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B--

1------11------21------31------41------51----- CP003006 Jnet ---HHHHHHHHHHHHH----EEE------EEEEEEE----EEE------E 19-31, 43-56 Jnet_25 ---B--BBBBBBBBBB----BBBB-B--BB-BBBBBBB-B---BBBBBB----B--B

1------11------21------31------41------51----- XM_001227411 Jnet -HHHHHHHHHHHHH------EE------EEEEEEEE------E 19-31, 46-56 Jnet_25 --BBBBBBBBBBBBBB----BBBBBB--BB-BBBBBBBBBBB-BBBBBB--B-B--B

1------11------21------31------41------51------XM_955172.1 Jnet --HHHHHHHHHHHHHHHH---EE------EEEEEEEE----EE------E 21-32, 44-57 Jnet_25 ---B--BBBBBBBBBB-B---BBBBBB--BB-BBBBBBB-B-B-BBBBBB----B--B

1------11------21------31------41------51------61----- GL891307 Jnet -HHHHHHHH------EEEE------EEEEEEEE------E 20-41, 56-66 Jnet_25 --B-BBBBBBB-B-B-B--BBB------BBBBBB--BB-BBBBBBBBB-B-BBBBBB--B-B--B

1------11------21------31------41------51------61 XM_955170 Jnet -HHHHHHHHHHHHHHHHHHHH------EE------EEEEEEEE------20-41, 47-61 Jnet_25 ----BBBBBBBBBBBBBBBBBBB-B--B--BBBBBB--BBBBBBBBBB-B-B-BBBBBB--

1------11------21------31------41------51------61------71- XM_003042519 Jnet ----HHHHHHHHHHHHHHE------EEEEE------EEEEEEE------E 33-47, 59-72 Jnet_25 -----BBBBBBBBBBBBBBB-B--B------BBBBBB--BBBBBBBBBBBB-B-BBBBBB-BB-B--B

1------11------21------31------41------51------AFQF01003703 Jnet --HHHHHHHHHHHHH------EEEE------EEEEEEEE------21-35, 47-60 Jnet_25 ---BBBBBBBBBBBBBB------BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B--

1------11------21------31------41------51------GL988040 Jnet ---HHHHHHHHHHHHHHHH---EEEE------EEEEEEEE---EEE------19-33, 45-58 Jnet_25 ---B-BBBBBBBB-BB-BB---BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B--

1------11------21------31------41------51------CP003011 Jnet --HHHHHHHHHHHH--HH-----EEEE------EEEEEEEE---EEE------20-34, 46-59 Jnet_25 ---BB-BBBBBBBBBBB-BB---BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B--

151------161------171------181------191------201------211 GL698514 Jnet ------EEEE------EEE-EEE---EEEE------EEEEEEE---- 155-176, 188-201 Jnet_25 B--BBB------BBBBBB--BB-BBBBBBB-B-B-BBBBBB--B-B-BBBB-B----B

GL698736 1------11------21------31------41------51------61------71------32-53, 65-78 Jnet ------E------EEEE------EEEEEE------

Jnet_25 --B--BBBBBB-B-BB-BBB---B---BBB-BBBB------BBBBBB--BB-BBBBBBBBBBB-BBBBBB--B-B-- Table S4 - The divergence times of the cerato-platanin protein genes analyzed, the corresponding fungi and the fungal host.

Host Fungi Cerato-platanin protein

(Divergence time of the earliest host, mya) (Divergence time) (Divergence time)

Animal: Domestic dog, human and bat (Hoog, 2000). Ajellomyces dermatitidis (30.496) GG749407 (0.4406)

Chiroptera (65.5-55.8) (He and Xu, 1990)

XM_002627464.1 (0.4406)

Animal: Horses and mules (Hoog, 2000). Ajellomyces capsulatus (30.496) GG692423 (8.6059)

Perissodactyla (33.9-55.8) (He and Xu, 1990)

XM_001538197.1 (8.6059)

Animal: Man, sheep, cattle, mice, mosquito (Mckenzie et al., 2004; Borkent and Grimaldi, 2004; Seye et al., 2009; Aspergillus clavatus (15.7816) XM_001275543.1 (21.7786)

Fedorova et al., 2008; Kellerman et al., 1976).

Diptera (90-100) (Borkent and Grimaldi, 2004; Seye et al., 2009)

Animal: Man, rats, dog and Canidne (Summerbell et al., 1992; Krockenberger, 2011). Aspergillus fischeri (5.1217) XM_001260716 (5.8735)

Rats (33.9-55.8) (Summerbell et al., 1992)

XM_001262681 (28.8235)

Animal: Mammals, nearly all domesticated animals, mice, rats, Drosophila melanogaster, birds and Galleria mellonella Aspergillus fumigatus (5.1217) XM_750502 (5.8735)

(Jackson et al., 2009; Slater et al., 2011; Hoog, 2000; Kozakiewicz, 1995; Onions, 1966)

Insects (359.2-416.0) (He and Xu, 1990)

XM_741783 (28.8235)

Animal: Man (Hoog, 2000). Aspergillus oryzae (4.669) XM_001821773 (0.0468)

Ramapithecus (1-1.4) (He and Xu, 1990)

Animal: Man, cattle, dog and other vertebrates such as pigeons (Onions, 1966; Kozakiewicz, 1995; Hoog, 2000). Aspergillus terreus (19.8517) XM_001208607 (27.1168)

Agnatha (443.7-488.3) (He and Xu, 1990)

Animal: Man, baboon, burro, cat, cattle, chimpanzee, chinchilla, coyote, dog, gorilla, horse, kangaroo, llama, mole, (29.5717) XM_003065932 (1.4562) monkey, mouse, pig, sea lion, sheep, squirrel, rabbit, rat, tapir and tiger (Huppert et al., 1980; Hoog, 2000).

Primates (65.5-145.5) (He and Xu, 1990)

XM_001247409.1 (1.4562)

Animal: Man and dog (Hoog, 2000). Cochliobolus lunatus (42.9626) AY291575.1 (13.7226)

Canidne (0.0117-2.588) (He and Xu, 1990)

Animal: Lepidoptera, Coleoptera, Hymenoptera and Bombyx mori (Brady, 1979; Willis, 1959). Cordyceps militaris (42.4107) JH126406 (34.9013)

Coleoptera (251-299) (He and Xu, 1990)

Animal: Grasshoppers (Wang et al., 2011). Metarhizium acridum (14.7139) GL698514 (6.7034)

Orthopteroidea (299.0-318.1) (He and Xu, 1990)

GL698536 (19.0758)

Animal: Curculio caryae (Bischoff et al., 2009). Metarhizium robertsii (14.7139) GL698736 (6.7034)

Coleopteroidea (251.0-299.0) (Ashworth and Kuschel, 2003)

GL698713 (19.0758)

Animal: Mammals (Hoog, 2000). Penicillium marneffei (29.9556) XM_002151034.1 (18.2058)

Mammalia (199.6-251.0) (He and Xu, 1990)

XM_002153087.1 (65.4761)

Animal: Human and horse (Summerbell et al., 1999). Trichophyton equinum (1.9195) DS995729 (6.9385)

Perissodactyla (33.9-55.8) (He and Xu, 1990)

Animal: Human (Stockdale, 1965; Hoog, 2000). Trichophyton gypseum (38.133) XM_003169712.1 (25.3185)

Ramapithecus (1-1.4) (He and Xu, 1990)

Animal: Human (Hoog, 2000). Trichophyton mentagrophytes (2.3302) XM_003016964.1 (3.2181)

Ramapithecus (1-1.4) (He and Xu, 1990)

Animal: Cats, dogs, monkeys, man, chimpanzee, chinchilla, fox, lion, pig, rabbit, sheep and tiger (Hoog, 2000; Stockdale, Trichophyton otae (51.1624) XM_002847168.1 (35.2783)

1965).

Eutheria (160) (Luo et al., 2011)

Animal: Human, cats and dogs (Hoog, 2000). Trichophyton rubrum (1.9195) XM_003235891 (4.2223)

Canidne (0.0117-2.588) (He and Xu, 1990)

Animal: Human, cattle and horses (Hoog, 2000). Trichophyton verrucosum (2.3302) XM_003023547.1 (3.2181)

Artiodactyla (33.9-55.8) (He and Xu, 1990)

Plant: carnations, Pisum, Solanum, wheat, barley, , oats, , Agropyron, Agrostis, Bromus, Calamagrostis, Fusarium graminearum (16.8699) XM_391381 (45.8278)

Cenchrus, Cortaderia, Cucumis, Echinochloa, Glycine, Hierochloe, Lolium, Lycopersicon, Medicago, Phleum, Poa,

Schizachyrium, Secale, Setaria, Sorghum, Spartina and Trifolium (Goswami and Kistler, 2004; Booth, 1971; Kubitzki,

2011). Table S4 continued

Plant (359.2-542.0) (He and Xu, 1990)

XM_390388 (6.2823)

Plant: Cereals, flax, Linaceae, hops, lupin, strawberry, tomato and potato (Booth, 1973). Gibberella pulicaris (21.7817) AY826795 (6.2823)

Fabaceae (90) (Nixon, 2006)

Plant: Cereal (Crouch et al., 2006; Mims and Vaillancourt, 2002). Glomerella graminicola (89.3449) GG697355 (52.8298)

Gramineae (33.9-55.8) (Whyte, 1978)

Plant: Brassica spp., Brassica oleracea, B. Rapa, B. napobrassica and other Cruciferae (Punithalingam, 1972). Leptosphaeria maculans (35.7989) AY099225.1 (41.6728)

Cruciferae (22-34) (Koch et al., 2000)

Plant: Triticum spp., Agropyron, Cinna, Dactylis, Deschampsia, Elymus, Festuca, Glyceria, Hordeum, Hystrix, Lepturus, Leptosphaeria nodorum (35.7989) XM_001803877 (13.7226)

Melica, Poa, Psamma, Secale and Stipa (Sprague, 1950; Sutton, 1966).

Gramineae (33.9-55.8) (Whyte, 1978)

Plant: Agropyron, Agrostis, Alopecurus, Anthoxanthum, Avena, Bromus, Chikusichloa, Dactylis, Digitaria, Echinochloa, Magnaporthe oryzae (101.692) XM_359969 (0.0972)

Eleusine, Festuca, Glyceria, Hierochloe, Holcus, Hordeum, Leersia, Lolium, Oplismenus, Oryza, Panicum, Phalaris,

Phleum, Poa, Secale, Setaria, Triticum, Zea and Zizania (Subramanian, 1968).

Gramineae (33.9-55.8) (Whyte, 1978)

EHA57569 (0.0972)

Plant: Lolium perenne, Secale vulgare, Triticum spp. and Triticale (Sivanesan, 1990). Mycosphaerella graminicola (111.9081) CM001199 (42.3212)

Poaceae (70) (Sheidai, 2008)

CM001204 (84.0655)

Plant: Wheat, oats and many other Gramineae (Ellis and Waller, 1973). Pyrenophora teres (9.1597) XM_003300750.1 (18.4081)

Gramineae (33.9-55.8) (Whyte, 1978)

Plant: Cereal and grasses. (Krupinsky, 1992; Wegulo, 2011) Pyrenophora tritici-repentis (9.1597) XM_001941085.1 (18.4081)

Gramineae (33.9-55.8) (Whyte, 1978)

Plant: Brassica oleracea var. capitata, B. chinensis, Helianthus annuus, Phaseolus vulgaris, Arachis hypogaea, Carthamus Sclerotinia sclerotiorum (10.2432) XM_001591342 (11.9373) tinctorius, Citrus, Coriandrum sativum, Cucumis melo, Curcurbita pepo, Glycine max, Lycopersicon esculentum, Nicotiana tabacum, Lactuca saliva, Hibiscus sabdariffa, Cucumis sativus, etc. (Yang, 1994)

Angiosperms (99.6-145.5) (He and Xu, 1990)

XM_001588499.1 (45.8278)

Plant: Theobroma spp. and Herrania spp (Holliday, 1970). Moniliophthora perniciosa (73.1294) EU250342.1 (90.1486)

Sterculiaceae (65.5-1.8) (Manchester, 1980)

EU250340.1 (42.1462)

EU250339.1 (0.2782)

XM_0023911 (0.2782)

EU250338 (0.3032)

Plant: Malus domestica and Sophora microphylla (Nixon, 2006). Schizophyllum commune (149.1018) XM_003032833 (45.1352)

Fabaceae (90) (Nixon, 2006)

XM_003037842.1 (45.1352)

GL377303.1 (101.2996)

XM_003037685.1

(103.5748)

Plant: Strawberries, grapes, cabbage, lettuce, horticultural crops, dicotyledonous and monocotyledonous hosts (Williamson Botryotinia fuckeliana (10.2432) XM_001552207.1 (0.4912) et al., 2007)

Angiospermae (99.6-145.5) (He and Xu, 1990)

XM_001559449.1 (2.7817)

FQ790260 (2.7817)

FQ790344 (0.4912)

CCD42656 (11.9373)

Plant: Anacardiaceae (Mangifera), Annonaceae (Annona), Apiaceace (Daucus), Araceae (Alocasia, Colocasia, Syngonium, Ceratocystis fimbriata (36.2461) EF017220 (1.3413)

Xanthosoma), Bignoniaceae (Spathodea), Brassicaceae (Mancoa), Caesalpiniaceae (Cassia), Convolvulaceae (Ipomoea),

Euphorbiaceae (Hevea, Manihot), Fabaceae (Crotalaria, Erythrina), Fagaceae (Fagus), Mimosaceae (Acacia, Inga),

Moraceae (Ficus), Myrtaceae (Eucalyptus, Pimenta), Punicaceae (Punica), Rubiaceae (Coffea), Rutaceae (Citrus),

Sterculiaceae (Herrania, Theobroma), Verbenaceae (Gmelina) (Morgan-Jones, 1967).

Angiospermae (99.6-145.5) (He and Xu, 1990)

EF017222 (1.959)

EF017223 (1.3413)

EF017225 (1.959) Table S4 continued

Plant: Platanus occidentalis, Platanus orientalis and Platanus acerifolia (Comparini et al., 2009) Ceratocystis platani (18.114) AJ311644.2 (15.919)

Platanus (115) (Feng et al., 2005)

Plant: Poplar (Comparini et al., 2009) Ceratocystis populicola (18.114) EF017219.1 (2.5472)

Salicaceae (55.8-65.5) (Manchester, 1986)

Plant: Oak and cherry (Stockey and Wehr, 1996; Comparini et al., 2009) Ceratocystis variospora (26.5296) EU330176.1 (2.5472)

Rosaceae (55.8) (He and Xu, 1990)

Animal: Arthropods, humans (Hoog, 2000; Booth, 1970). Fusarium oxysporum (16.8699) AFQF01003703 (15.3899)

Plant: Crop plants (Hoog, 2000; Booth, 1970).

Arthropods (488.3-542.0) (He and Xu, 1990)

AFQF01002046 (29.3638)

AFQF01003174 (2.0685)

AFQF01004521 (23.6173)

AFQF01002021 (13.1918)

Animal: Man, cattle, mice, birds, and insects (Galleria mellonella, silkworms, grasshoppers, houseflies and mealy bugs) Aspergillus flavus (4.669) XM_002379542.1 (0.0468)

(Scully and Bidochka, 2006; Mellon et al., 2007).

Plant: Seedling plants (Raper and Fennell, 1965; Ainsworth and Austwick, 1959; Austwick, 1965; Lancaster et al., 1961;

Wogan, 1965; Clinton, 1960; Diener et al., 1965; Onions, 1966).

Orthopteroidea (299.0-318.1) (Wang et al., 2011)

XM_002372112 (25.7494)

Animal: Man, animals (Onions, 1966; Hoog, 2000). Aspergillus niger (19.8517) XM_001399258 (35.6689)

Plant: Some crop plants, sorghum and jute, onion, garlic and shallot, Dracaena, Sansevieria, cotton (Onions, 1966; Hoog,

2000).

Asparagales (~105) (Walker and Walker, 1984)

Fungi: Pathogen. Trichoderma asperellum (7.6697) AJ902344 (2.8025)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

HM572232 (0.6767)

Fungi: Pathogen. Trichoderma atroviride (3.1622) AJ905125 (0.1004)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

DQ464903 (14.0812)

AJ901879 (0.0042)

Fungi: Pathogen. Trichoderma harzianum (3.6747) GU452499.2 (15.881)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

Fungi: Pathogen. Trichoderma virens (3.6747) GL985082 (6.2254)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

DQ494198 (2.4404)

DQ121133 (0.1004)

Fungi: Pathogen Trichoderma viride (3.1622) AJ907943.1 (0.0042)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

Fungi: Pathogen Trichoderma reesei (10.3573) DQ494199 (6.2254)

Phytoparasitic pathogen (307.2-299.0) (Stubblefleld et al., 1988)

GL985109 (51.3952)

GL985084 (34.9013)

GL985072 (55.9755)

- Chaetomium globosum (22.9123) XM_001227411 (19.8895)

XM_001225018 (13.2992)

- Chaetomium thermophilum (40.6496) GL988040 (25.8873)

GL988047 (13.2992)

- Neurospora crassa (0.7272) XM_955172.1 (22.5699)

XM_955170 (9.9472)

XM_953615 (4.4373)

- Neurospora tetrasperma (0.7272) GL891307 (9.9472)

GL891302 (4.4373)

- Penicillium stipitatum (29.9556) EQ962652.1 (18.2058)

XM_002488289.1 (65.4761)

- Podospora anserina (32.6344) XM_001911119.1 (31.7663)

- Sordaria macrospora (13.2075) CABT01000049.1 (15.3161) Table S4 continued

- Thielavia heterothallica (22.9123) CP003003 (38.6567)

CP003006 (19.8895)

- Thielavia terrestris (30.386) CP003011 (25.8873)

CP003009 (20.2319)

- Tuber melanosporum (102.3861) XM 0028365 (107.3721)

- (29.5717) XM_002541561 (85.7527)

- Coprinopsis cinerea (73.1294) XM_001841154.2 (117.4409)

XM_001835298 (51.6831)

XM_001839769.2 (70.918)

XM_001839768 (70.918)

XM_001835299 (51.6831)

- Laccaria bicolor (141.1667) XM_001878434.1

(124.0826)

- Postia placenta (110.1579) XM_002473473 (97.834)

XM_002474905 (62.3655)

XM_002476911.1 (96.0187)

- (146.6283) GL945438

EGO21846 (39.5425)

GL945438

EGO21849 (39.5425)

GL945438

EGO21851 (7.1622)

GL945438

EGO21848 (0.0444)

GL945438

EGO20689 (47.4644)

GL945438

EGN96311 (0.0444)

GL945438

EGN96315 (47.4644)

- Taiwanofungus camphorates (110.1579) AY569691.1 (72.7549)

DQ444459.1 (62.3655)

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Table S5 - Cumulative substitutions in branches with positive selection. Substitutions Branch Synonymous Non-synonymous Total dN-dS dN/dS XM_001878434.1 51.6667 55.3333 107 3.6666 1.070966 XM_001835299 46.8333 57.1667 104 10.3334 1.220642 EU250342.1 31 52 83 21 1.677419 XM_003037842.1 31.3333 32.6667 64 1.3334 1.042555 GL377303.1 43.0833 94.9167 138 51.8334 2.203097 XM_002473473 63.6667 87.3333 151 23.6666 1.371727 XM_002836502.1 53.8333 77.1667 131 23.3334 1.433438 ADOT01000154 38.9167 73.0833 112 34.1666 1.877942 JH126406 44.5 62.5 107 18 1.404494 GL698536 14 21 35 7 1.5 XM_001591342 54.1667 55.8333 110 1.6666 1.030768 XM_001227411 30 41 71 11 1.366667 XM_955172.1 43.5 58.5 102 15 1.344828 GL988040 42.25 42.75 85 0.5 1.011834 CM001204 69.6667 144.333 214 74.6663 2.071765 AY569691.1 40.8333 44.1667 85 3.3334 1.081634 XM_001841154.2 54.3333 76.6667 131 22.3334 1.411044 GL945438 30.3333 69.6667 100 39.3334 2.296707 EGO20689 XM_003037685.1 35.5 78.5 114 43 2.211268 XM_002474905 55.3333 94.6667 150 39.3334 1.710845 JF699730 20 55 75 35 2.75 XM_001275543.1 21.5 30.5 52 9 1.418605 XM_001208607 18 41 59 23 2.277778 XM_001399258 30.8333 37.1667 68 6.3334 1.205408 XM_359969 18.1667 21.8333 40 3.6666 1.201831 XM_658785 61.6667 74.3333 136 12.6666 1.205404 AFQF01004521 34.5 41.5 76 7 1.202899 GL985072 21.6667 65.3333 87 43.6666 3.015378 CP003011 32.8333 39.1667 72 6.3334 1.192896 XM_741783 43.3333 62.6667 106 19.3334 1.446156 GL945438 34.6667 58.3333 93 23.6666 1.68269 EGO21849 XM_001262681 3.5 17.5 21 14 5 AY291575.1 15 27 42 12 1.8 CM001199 51 70 121 19 1.372549 CCD42656 6.5 17.5 24 11 2.692308 XM_001835298 1.5 8.5 10 7 5.666667 GL945438 5 12 17 7 2.4 EGO21851 GL945438 30 71 101 41 2.366667 EGN96315 XM_003032833 24.5 34.5 59 10 1.408163 EU250340.1 52.3333 57.6667 110 5.3334 1.101912 AY099225.1 39.5 63.5 103 24 1.607595 XM_002541561 30.5 37.5 68 7 1.229508 XM_001538197.1 5.33333 7.66667 13 2.33334 1.437502 AFQF01003174 15.5 35.5 51 20 2.290323 XM_001225018 41.1667 56.8333 98 15.6666 1.380565 XM_002153087.1 1 12 13 11 12 CP003009 23.6667 24.3333 48 0.6666 1.028166 XM_001941085.1 9 10 19 1 1.111111 GL698713 5 9 14 4 1.8 EF017219.1 3 7 10 4 2.333333 EU330176.1 4 7 11 3 1.75 XM_003300750.1 8 27 35 19 3.375 EF017223 0 1 1 1 - EF017222 0 2 2 2 - GG697355 0 2 2 2 - EF017225 0 4 4 4 -

Table S5 continued

Figure S1 - Phylogenetic relationships and divergence times of fungi with known genes in the cerato-platanin family. Figure S2 - Phylogenetic relationship and divergence times of genes in the cerato-platanin family of Ascomycetes. Figure S3 - Phylogenetic relationship and divergence times of genes in the cerato-platanin family of Basidiomycetes.