Functional Somatic Symptoms in Children and Adolescents a Stress-System Approach to Assessment and Treatment
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Childhood Functional Gastrointestinal Disorders: Child/Adolescent
Gastroenterology 2016;150:1456–1468 Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s Hospital, Columbus, Ohio; 3Baylor College of Medicine, Children’s Nutrition Research Center, Texas Children’s Hospital, Houston, Texas; 4Department of Translational Science, Section of Pediatrics, University of Naples, Federico II, Naples, Italy; and 5Department of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Characterization of childhood and adolescent functional Rome III criteria emphasized that there should be “no evi- gastrointestinal disorders (FGIDs) has evolved during the 2- dence” for organic disease, which may have prompted a decade long Rome process now culminating in Rome IV. The focus on testing.1 In Rome IV, the phrase “no evidence of an era of diagnosing an FGID only when organic disease has inflammatory, anatomic, metabolic, or neoplastic process been excluded is waning, as we now have evidence to sup- that explain the subject’s symptoms” has been removed port symptom-based diagnosis. In child/adolescent Rome from diagnostic criteria. Instead, we include “after appro- IV, we extend this concept by removing the dictum that priate medical evaluation, the symptoms cannot be attrib- “ ” fi there was no evidence for organic disease in all de ni- uted to another medical condition.” This change permits “ tions and replacing it with after appropriate medical selective or no testing to support a positive diagnosis of an evaluation the symptoms cannot be attributed to another FGID. -
Gastro-Esophageal Reflux in Children
International Journal of Molecular Sciences Review Gastro-Esophageal Reflux in Children Anna Rybak 1 ID , Marcella Pesce 1,2, Nikhil Thapar 1,3 and Osvaldo Borrelli 1,* 1 Department of Gastroenterology, Division of Neurogastroenterology and Motility, Great Ormond Street Hospital, London WC1N 3JH, UK; [email protected] (A.R.); [email protected] (M.P.); [email protected] (N.T.) 2 Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Napoli, Italy 3 Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK * Correspondence: [email protected]; Tel.: +44(0)20-7405-9200 (ext. 5971); Fax: +44(0)20-7813-8382 Received: 5 June 2017; Accepted: 14 July 2017; Published: 1 August 2017 Abstract: Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are often distinct from classic ones such as heartburn. The passage of gastric contents into the esophagus is a normal phenomenon occurring many times a day both in adults and children, but, in infants, several factors contribute to exacerbate this phenomenon, including a liquid milk-based diet, recumbent position and both structural and functional immaturity of the gastro-esophageal junction. This article focuses on the presentation, diagnosis and treatment of GERD that occurs in infants and children, based on available and current guidelines. -
Interoception: the Sense of the Physiological Condition of the Body AD (Bud) Craig
500 Interoception: the sense of the physiological condition of the body AD (Bud) Craig Converging evidence indicates that primates have a distinct the body share. Recent findings that compel a conceptual cortical image of homeostatic afferent activity that reflects all shift resolve these issues by showing that all feelings from aspects of the physiological condition of all tissues of the body. the body are represented in a phylogenetically new system This interoceptive system, associated with autonomic motor in primates. This system has evolved from the afferent control, is distinct from the exteroceptive system (cutaneous limb of the evolutionarily ancient, hierarchical homeostatic mechanoreception and proprioception) that guides somatic system that maintains the integrity of the body. These motor activity. The primary interoceptive representation in the feelings represent a sense of the physiological condition of dorsal posterior insula engenders distinct highly resolved the entire body, redefining the category ‘interoception’. feelings from the body that include pain, temperature, itch, The present article summarizes this new view; more sensual touch, muscular and visceral sensations, vasomotor detailed reviews are available elsewhere [1,2]. activity, hunger, thirst, and ‘air hunger’. In humans, a meta- representation of the primary interoceptive activity is A homeostatic afferent pathway engendered in the right anterior insula, which seems to provide Anatomical characteristics the basis for the subjective image of the material self as a feeling Cannon [3] recognized that the neural processes (auto- (sentient) entity, that is, emotional awareness. nomic, neuroendocrine and behavioral) that maintain opti- mal physiological balance in the body, or homeostasis, must Addresses receive afferent inputs that report the condition of the Atkinson Pain Research Laboratory, Division of Neurosurgery, tissues of the body. -
June 26, 1995
Volume$3.00Mail Registration ($2.8061 No. plusNo. 1351 .20 GST)21-June 26, 1995 rn HO I. Y temptation Z2/Z4-8I026 BUM "temptation" IN ate, JUNE 27th FIRST SIN' "jersey girl" r"NAD1AN TOUR DATES June 24 (2 shows) - Discovery Theatre, Vancouver June 27 a 28 - St. Denis Theatre, Montreal June 30 - NAC Theatre, Ottawa July 4 - Massey Hall, Toronto PRODUCED BY CRAIG STREET RPM - Monday June 26, 1995 - 3 theUSArts ireartstrade of and andrepresentativean artsbroadcasting, andculture culture Mickey film, coalition coalition Kantorcable, representing magazine,has drawn getstobook listdander publishing companiesKantor up and hadthat soundindicated wouldover recording suffer thatKantor heunder wasindustries. USprepared trade spokespersonCanadiansanctions. KeithThe Conference for announcement theKelly, coalition, nationalof the was revealed Arts, expecteddirector actingthat ashortly. of recent as the a FrederickPublishersThe Society of Canadaof Composers, Harris (SOCAN) Authors and and The SOCANand Frederick Music project.the preview joint participation Canadian of SOCAN and works Harris in this contenthason"areGallup the theconcerned information Pollresponsibilityto choose indicated about from.highway preserving that to He ensure a and alsomajority that our pointedthere culturalthe of isgovernment Canadiansout Canadian identity that in MusiccompositionsofHarris three MusicConcert newCanadian Company at Hallcollections Toronto's on pianist presentedJune Royal 1.of Monica Canadian a Conservatory musical Gaylord preview piano of Chatman,introducedpresidentcomposers of StevenGuest by the and their SOCAN GellmanGaylord.speaker respective Foundation, and LouisThe composers,Alexina selections Applebaum, introduced Louie. Stephen were the originatethatisspite "an 64% of American the ofKelly abroad,cultural television alsodomination policies mostuncovered programs from in of place ourstatisticsscreened the media."in US; Canada indicatingin 93% Canada there of composersdesignedSeriesperformed (Explorations toThe the introduceinto previewpieces. -
Russell-Mills-Credits1
Russell Mills 1) Bob Marley: Dreams of Freedom (Ambient Dub translations of Bob Marley in Dub) by Bill Laswell 1997 Island Records Art and design: Russell Mills (shed) Design assistance, image melts: Michael Webster (storm) Paintings: Russell Mills 2) The Cocteau Twins: BBC Sessions 1999 Bella Union Records Art and design: Russell Mills (shed) Design assistance and image melts: Michael Webster (storm) 3) Gavin Bryars: The Sinking Of The Titanic / Jesus' Blood Never Failed Me Yet 1998 Virgin Records Art and design: Russell Mills Design assistance and image melts: Michael Webster (storm) Paintings and assemblages: Russell Mills 4) Gigi: Illuminated Audio 2003 Palm Pictures Art and design: Russell Mills (shed) Design assistance: Michael Webster (storm) Photography: Jean Baptiste Mondino 5) Pharoah Sanders and Graham Haynes: With a Heartbeat - full digipak 2003 Gravity Art and design: Russell Mills (shed) Design assistance: Michael Webster (storm) Paintings and assemblages: Russell Mills 6) Hector Zazou: Songs From The Cold Seas 1995 Sony/Columbia Art and design: Russell Mills and Dave Coppenhall (mc2) Design assistance: Maggi Smith and Michael Webster 7) Hugo Largo: Mettle 1989 Land Records Art and design: Russell Mills Design assistance: Dave Coppenhall Photography: Adam Peacock 8) Lori Carson: The Finest Thing - digipak front and back 2004 Meta Records Art and design: Russell Mills (shed) Design assistance: Michael Webster (storm) Photography: Lori Carson 9) Toru Takemitsu: Riverrun 1991 Virgin Classics Art & design: Russell Mills Cover -
Exposure to Negative Socio-Emotional Events Induces Sustained Alteration of Resting-State Brain Networks in the Elderly
Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in the elderly Sebastian Baez Lugo ( [email protected] ) University of Geneva https://orcid.org/0000-0002-7781-2387 Yacila Deza-Araujo University Of Geneva https://orcid.org/0000-0002-2624-077X Fabienne Collette University of Liège https://orcid.org/0000-0001-9288-9756 Patrik Vuilleumier Lab NIC https://orcid.org/0000-0002-8198-9214 Olga Klimecki University of Geneva https://orcid.org/0000-0003-0757-7761 and The Medit-Ageing Research group Research Article Keywords: Ageing, Anxiety, Rumination, Emotional resilience, Default Mode Network, Functional connectivity, Amygdala, Insula, Posterior cingulate cortex, fMRI Posted Date: November 3rd, 2020 DOI: https://doi.org/10.21203/rs.3.rs-91196/v2 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License 1 Title: 2 Exposure to negative socio-emotional events induces sustained alteration of 3 resting-state brain networks in the elderly 4 5 6 Authors: 7 Sebastian Baez Lugo1,2,*, Yacila I. Deza-Araujo1,2, Fabienne Collette3, Patrik Vuilleumier1,2, Olga 8 Klimecki1,4, and the Medit-Ageing Research Group 9 10 Affiliations: 11 1 Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. 12 2 Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, 13 Medical School, University of Geneva, Geneva, Switzerland. 14 3 GIGA-CRC In Vivo Imaging Research Unit, University of Liège, Liège, Belgium. 15 4 Psychology Department, Technische Universität Dresden, Dresden, Germany. 16 17 * Correspondence concerning this article should be addressed to: [email protected] 18 1 19 Abstract: 20 Socio-emotional functions seem well-preserved in the elderly. -
Pathophysiology, Differential Diagnosis and Management of Rumination Syndrome Kathleen Blondeau, Veerle Boecxstaens, Nathalie Rommel, Jan Tack
Review article: pathophysiology, differential diagnosis and management of rumination syndrome Kathleen Blondeau, Veerle Boecxstaens, Nathalie Rommel, Jan Tack To cite this version: Kathleen Blondeau, Veerle Boecxstaens, Nathalie Rommel, Jan Tack. Review article: pathophysiol- ogy, differential diagnosis and management of rumination syndrome. Alimentary Pharmacology and Therapeutics, Wiley, 2011, 33 (7), pp.782. 10.1111/j.1365-2036.2011.04584.x. hal-00613928 HAL Id: hal-00613928 https://hal.archives-ouvertes.fr/hal-00613928 Submitted on 8 Aug 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Alimentary Pharmacology & Therapeutic Review article: pathophysiology, differential diagnosis and management of rumination syndrome ForJournal: Alimentary Peer Pharmacology Review & Therapeutics Manuscript ID: APT-1105-2010.R2 Wiley - Manuscript type: Review Article Date Submitted by the 09-Jan-2011 Author: Complete List of Authors: Blondeau, Kathleen; KULeuven, Lab G-I Physiopathology Boecxstaens, Veerle; University of Leuven, Center for Gastroenterological Research Rommel, Nathalie; University of Leuven, Center for Gastroenterological Research Tack, Jan; University Hospital, Center for Gastroenterological Research Functional GI diseases < Disease-based, Oesophagus < Organ- Keywords: based, Diagnostic tests < Topics, Motility < Topics Page 1 of 24 Alimentary Pharmacology & Therapeutic 1 2 3 EDITOR'S COMMENTS TO AUTHOR: 4 Please consider the points raised by the reviewers. -
Traumatic Stress and the Autonomic Brain‐Gut Connection in Development: Polyvagal Theory As an Integrative Framework for Psychosocial and Gastrointestinal Pathology
Received: 9 July 2018 | Revised: 12 February 2019 | Accepted: 23 February 2019 DOI: 10.1002/dev.21852 SPECIAL ISSUE Traumatic stress and the autonomic brain‐gut connection in development: Polyvagal Theory as an integrative framework for psychosocial and gastrointestinal pathology Jacek Kolacz1 | Katja K. Kovacic2 | Stephen W. Porges1,3 1Traumatic Stress Research Consortium at the Kinsey Institute, Indiana University, Abstract Bloomington, Indiana A range of psychiatric disorders such as anxiety, depression, and post‐traumatic 2 Division of Pediatric Gastroenterology, stress disorder frequently co‐occur with functional gastrointestinal (GI) disorders. Hepatology & Nutrition, Department of Pediatrics, Medical College of Wisconsin, Risk of these pathologies is particularly high in those with a history of trauma, abuse, Milwaukee, Wisconsin, USA and chronic stress. These scientific findings and rising awareness within the health‐ 3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, care profession give rise to a need for an integrative framework to understand the North Carolina developmental mechanisms that give rise to these observations. In this paper, we in‐ Correspondence troduce a plausible explanatory framework, based on the Polyvagal Theory (Porges, Jacek Kolacz, the Traumatic Stress Research Psychophysiology, 32, 301–318, 1995; Porges, International Journal of Psychophysiology, Consortium at the Kinsey Institute, Indiana University, Bloomington, IN. 42, 123–146, 2001; Porges, Biological Psychology, 74, 116–143, 2007), which de‐ Email: [email protected] scribes how evolution impacted the structure and function of the autonomic nervous system (ANS). The Polyvagal Theory provides organizing principles for understand‐ ing the development of adaptive diversity in homeostatic, threat‐response, and psy‐ chosocial functions that contribute to pathology. -
MATURING out an Empirical Study of Personal Histories and Processes in Hard-Drug Addiction
MATURING OUT An empirical study of personal histories and processes in hard-drug addiction ER UIT GROEIEN Een empirische studie van levensbeschrijvingen en processen in harddrugverslaving mijn maeder is mijn naam vergeten, mijn kind weet nag niet hoe ik heet. hoe maet ik mij gebargen welen? no em mij, bevestig mijn beslaan, laat mijn naam zijn als een kelen. naem lIIij, naem fIIij, spreek mij aan, 0, naem mij bij mijn diepste naam. vaal' wie ik liejheb, wi! ik helen. Neeltje Maria Min. Maturing out An empirical study of personal histories and processes in hard-drug addiction Er uit groeien Een empirische studie van levensbeschrijvingen en processen in harddrugverslaving PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof. Dr. P. W.C. Akkermans M.A. en volgens het beslnit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 25 jannari 1995 om 15.45 nnr. door ENGEL HENDRICUS PRINS geboren te Amsterdam Promotiecommissie Promotor: Prof.Dr. W.J. Schudel Promotor: Prof.Dr. F. Schutze Overige leden: Prof.Dr. H.F.L. Gat'l'etsen Prof.Dr. F.e. Verhulst Contents Preface VIII 1 History of the study 1.1 Introduction I 2 Framen'ork 5 2.1 The setting of the project 5 2.2 The aims 6 2.3 The relevant literature 6 2.4 Changes in the environment since Winick's study 9 2.4.1 The availability of drugs 9 2.4.2 The variaty of drugs 9 2.4.3 Attitude of society 10 2.4.4 AIDS 10 3 Methodology II 3.1 The Design II 3.1.1 The sample criteria 12 3.1.2 The -
The Guide to Eating Disorder Recovery in Nashville
Eating disorders have the highest mortality rate of any mental illness. The Guide To Without treatment, Eating Disorder up to 20 percent of people diagnosed Recovery In with a serious ED die. With treatment, Nashville however, the mortality rate falls to 2 to 3 percent. Introduction Eating disorders, also known as ED, are serious, often fatal illnesses that involve severe disruption in a person’s relationship with food. Behaviors, thoughts, emotions—all become disturbed when an ED begins to develop. Common EDs include anorexia nervosa, bulimia nervosa, and binge-eating disorder (BED). Eating disorders have the highest mortality rate of any mental illness. Without treatment, up to 20 percent of people diagnosed with a serious ED die. With treatment, however, the mortality rate falls to 2 to 3 percent. The causes of ED are not clear, though both biological and environmental factors play a role, as does the culture’s idealization of thinness. People who have experienced sexual abuse or trauma are more likely to develop an ED, while intellectual disabilities can contribute to the development of lesser known disorders like pica (where people eat non-food items) and rumination syndrome (where people regurgitate food). Anxiety, depression, and substance abuse are common among people with ED. While ED can affect people of all ages, racial and ethnic backgrounds, body weights, and genders, they have been found to be more common in developed countries than less developed countries. Some general statistics of ED: • At least 30 million people, of all ages and genders, suffer from ED in the U.S. • At least one person dies as a direct result of an ED every 62 minutes. -
11A. GI Manifestations of Psychologic Disorders
11A. GI Manifestations of Psychologic Disorders Meredith Hitch, MD Robert Rothbaum, MD I. Psychogenic Associations Many psychological disorders have associated gastrointestinal manifestations. While evaluating a child for chronic abdominal pain, it is important to consider psychologic as well as organic etiologies for the symptoms II. Mood Disorder and Anxiety—Chronic Abdominal Pain A. There is a vicious cycle involving chronic pain, depression, and anxiety, each provoking the other B. Anxiety disorder is found in 80% of children with recurrent abdominal pain (RAP) in some studies C. Depressive symptoms found in 40% of children with RAP D. Possible explanations 1. Pain evokes mood and anxiety disorders 2. Affective disorders cause or exacerbate pain 3. A common biological predisposition underlies both problems 4. Common characteristics of both include somatization, social stress, and poor coping E. Life stressors provoke 1. Physiologic stress response with increased ccorticotropin-releasing factor (CRF) 2. CRF causes ↑ intestinal motility, hyperalgesia, psychoemotional inflammatory responses F. Typical life stresses 1. Maternal separation 2. Conflicting maternal relationships 3. Abusive environments – sexual or physical 4. Traumatic events – death, major illness, geographic dislocation 5. Marital discord 6. Peer pressure 7. Perfectionism III. Pathologic Aerophagia—Abdominal Distension A. Symptoms: eructation, abdominal cramping, flatulence, chronic diarrhea B. Tympanitic abdomen with very hyperactive bowel sounds C. Plain abdominal film showing uniform gassy distension from esophagus to rectum, without air fluid levels D. Hallmarks: 1. Increasing abdominal distension throughout the day 2. Increased flatus at night E. Visable air swallowing is often subtle and hard to detect F. Signs of abuse or stress IV. Mental Retardation/Anxiety/Obsessive Compulsive Disorder (OCD)— Solitary Rectal Ulcer Syndrome A. -
Open Access Version Via Utrecht University Repository
Understanding Conflict Dynamics: A Comparative Analysis of Ethno-Separatist Conflicts in India and the Philippines Voor een beter begrip van conflictdynamiek: een vergelijkende analyse van etnisch- seperatistische conflicten in India en de Filippijnen (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op vrijdag 18 oktober 2013 des middags te 2.30 uur door Alastair Grant Reed geboren op 7 december 1978 te Oxford, United Kingdom PROMOTOREN: Prof.dr. D.A. Hellema Prof.dr. B.G.J. de Graaff Prof.dr. I.G.B.M. Duyvesteyn This thesis was accomplished with financial support from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO). CONTENTS Acknowledgements ix 1 Introduction 1 The research question 3 A survey of theories on irregular conflicts 7 Causes of conflicts 9 How conflicts progress after they have started 15 The role of the state 21 The population and popular support 26 The role of peace processes 28 Theories of foreign support/international relations 30 Theories on geography 31 How violence ends 33 Theoretical insights 35 The research model 36 Research design 44 Case study selection 49 Why Asia? 51 Originality claim 56 2 The Naga Insurgency 59 Part 1: The background to the conflict 59 Part 2: The phases of the Naga Insurgency 64 Phase 1: 1947 to 1957 – a national struggle 65 Phase 2: 1957 to 1964 – the road