Interview The Inventiveness of Nature: An Interview with Werner Arber Jane Gitschier* Departments of Medicine and Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America Image 1. Werner Arber stands outside the Biozentrum at the University of Basel, Switzerland. doi:10.1371/journal.pgen.1004879.g001 I admit to having a soft spot for the years, restriction and modification was not spawned extremely useful technology. In bacterial phenomenon of host-specific only a remarkable story in itself, but also past issues, I have interviewed Hamilton modification and restriction. I vividly remember first learning about this mech- Citation: Gitschier J (2014) The Inventiveness of Nature: An Interview with Werner Arber. PLoS Genet 10(12): anism to stave off marauding DNA as a e1004879. doi:10.1371/journal.pgen.1004879 beginning graduate student in the mid- Published December 18, 2014 1970s. Preceding the discovery of its Copyright: ß 2014 Jane Gitschier. This is an open-access article distributed under the terms of the Creative modern-day defensive counterpart, Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, CRISPR (clustered regularly interspaced provided the original author and source are credited. short palindromic repeats) by about 50 * Email:
[email protected] PLOS Genetics | www.plosgenetics.org 1 December 2014 | Volume 10 | Issue 12 | e1004879 Smith, who isolated the first type II Edouard Kellenberger, who ran the La- new preparation techniques. You could restriction enzyme, as well as Herb boratoire de Biophysique in the basement spread the lysate out on the film and see Boyer, whose production of recombinant of the Institute of Physics there.